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Network neighborhood for query Sequence : RPGF3_HUMAN

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RPGF3_HUMAN
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPGF3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	0 (rank : 2)	NC score	0.993381 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF4_HUMAN
θ value	0 (rank : 3)	NC score	0.971820 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	88	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	0 (rank : 4)	NC score	0.971134 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_MOUSE
θ value	2.1455e-110 (rank : 5)	NC score	0.912210 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	1.95407e-87 (rank : 6)	NC score	0.908614 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF2_HUMAN
θ value	1.08726e-37 (rank : 7)	NC score	0.683598 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	5.0505e-35 (rank : 8)	NC score	0.662897 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	266	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF1_HUMAN
θ value	3.39556e-23 (rank : 9)	NC score	0.680585 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GRP3_HUMAN
θ value	2.60593e-15 (rank : 10)	NC score	0.486599 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GNRP_HUMAN
θ value	9.90251e-15 (rank : 11)	NC score	0.487334 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	2.20605e-14 (rank : 12)	NC score	0.475604 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_HUMAN
θ value	1.2105e-12 (rank : 13)	NC score	0.480076 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	1.2105e-12 (rank : 14)	NC score	0.479933 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	6.00763e-12 (rank : 15)	NC score	0.492064 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

CT152_MOUSE
θ value	8.11959e-09 (rank : 16)	NC score	0.385360 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KAP1_HUMAN
θ value	1.38499e-08 (rank : 17)	NC score	0.365823 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

CT152_HUMAN
θ value	2.36244e-08 (rank : 18)	NC score	0.393680 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KGP2_HUMAN
θ value	3.08544e-08 (rank : 19)	NC score	0.088054 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	1023	Shared Neighborhood Hits	24
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP1_MOUSE
θ value	5.26297e-08 (rank : 20)	NC score	0.362396 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KGP2_MOUSE
θ value	6.87365e-08 (rank : 21)	NC score	0.087831 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	1029	Shared Neighborhood Hits	24
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP0_HUMAN
θ value	4.45536e-07 (rank : 22)	NC score	0.344202 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	52	Shared Neighborhood Hits	26
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	4.45536e-07 (rank : 23)	NC score	0.345997 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

RGL2_MOUSE
θ value	7.59969e-07 (rank : 24)	NC score	0.388509 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

PREX1_HUMAN
θ value	1.69304e-06 (rank : 25)	NC score	0.176752 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RGL2_HUMAN
θ value	1.69304e-06 (rank : 26)	NC score	0.381938 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

KAP2_HUMAN
θ value	2.88788e-06 (rank : 27)	NC score	0.328488 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	4.92598e-06 (rank : 28)	NC score	0.330399 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	24
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
θ value	1.43324e-05 (rank : 29)	NC score	0.324089 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
θ value	1.87187e-05 (rank : 30)	NC score	0.323212 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

GNDS_MOUSE
θ value	9.29e-05 (rank : 31)	NC score	0.394686 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

KGP1A_HUMAN
θ value	9.29e-05 (rank : 32)	NC score	0.079588 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	901	Shared Neighborhood Hits	25
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	9.29e-05 (rank : 33)	NC score	0.079642 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	921	Shared Neighborhood Hits	25
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	9.29e-05 (rank : 34)	NC score	0.079356 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	922	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

RGL1_HUMAN
θ value	0.000121331 (rank : 35)	NC score	0.413219 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

SH2D3_MOUSE
θ value	0.000158464 (rank : 36)	NC score	0.163617 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GNDS_HUMAN
θ value	0.00035302 (rank : 37)	NC score	0.379420 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

SH2D3_HUMAN
θ value	0.00102713 (rank : 38)	NC score	0.154418 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

BCAR3_MOUSE
θ value	0.0431538 (rank : 39)	NC score	0.083146 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CNGB1_HUMAN
θ value	0.0563607 (rank : 40)	NC score	0.101238 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

RGL1_MOUSE
θ value	0.0736092 (rank : 41)	NC score	0.375674 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGDSR_HUMAN
θ value	0.163984 (rank : 42)	NC score	0.308207 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

NMI_HUMAN
θ value	0.21417 (rank : 43)	NC score	0.034806 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q13287, Q53TI8, Q9BVE5	Gene names	NMI
Domain Architecture
Description	N-myc-interactor (Nmi) (N-myc and STAT interactor).

CNGA1_HUMAN
θ value	0.279714 (rank : 44)	NC score	0.062787 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	149	Shared Neighborhood Hits	23
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

IRF5_MOUSE
θ value	0.47712 (rank : 45)	NC score	0.024673 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

CNGA1_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.058551 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

SH23A_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.065251 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

PELP1_MOUSE
θ value	1.81305 (rank : 48)	NC score	0.019168 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	709	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

CNGA3_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.056207 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	125	Shared Neighborhood Hits	21
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

AT2A1_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.010293 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	O14983, O14984	Gene names	ATP2A1
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

CNGA3_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.055140 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

AT2A1_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.009910 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R429	Gene names	Atp2a1
Domain Architecture	No domain graphic available
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

AT2A2_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.009376 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P16615, P16614	Gene names	ATP2A2, ATP2B
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8) (Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

AT2A2_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.009369 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O55143, Q9R2A9, Q9WUT5	Gene names	Atp2a2
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8) (Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

CS021_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.010847 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D279, Q3UI04	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21 homolog.

KCNH6_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.025947 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	222	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

BCAR3_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.050792 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

CNGA2_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.057647 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGB3_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.073995 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.083191 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

FYV1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.050931 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	191	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GP155_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.123922 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

HCN2_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.056784 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	369	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.057665 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	278	Shared Neighborhood Hits	22
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

Hits sorted by NC score

RPGF3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.993381 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	54	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF4_HUMAN
NC score	0.971820 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	88	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.971134 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_MOUSE
NC score	0.912210 (rank : 5)	θ value	2.1455e-110 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
NC score	0.908614 (rank : 6)	θ value	1.95407e-87 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF2_HUMAN
NC score	0.683598 (rank : 7)	θ value	1.08726e-37 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF1_HUMAN
NC score	0.680585 (rank : 8)	θ value	3.39556e-23 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF6_HUMAN
NC score	0.662897 (rank : 9)	θ value	5.0505e-35 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	266	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SOS2_HUMAN
NC score	0.492064 (rank : 10)	θ value	6.00763e-12 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
NC score	0.487334 (rank : 11)	θ value	9.90251e-15 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GRP3_HUMAN
NC score	0.486599 (rank : 12)	θ value	2.60593e-15 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

SOS1_HUMAN
NC score	0.480076 (rank : 13)	θ value	1.2105e-12 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.479933 (rank : 14)	θ value	1.2105e-12 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GNRP_MOUSE
NC score	0.475604 (rank : 15)	θ value	2.20605e-14 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RGL1_HUMAN
NC score	0.413219 (rank : 16)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.394686 (rank : 17)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

CT152_HUMAN
NC score	0.393680 (rank : 18)	θ value	2.36244e-08 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

RGL2_MOUSE
NC score	0.388509 (rank : 19)	θ value	7.59969e-07 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

CT152_MOUSE
NC score	0.385360 (rank : 20)	θ value	8.11959e-09 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

RGL2_HUMAN
NC score	0.381938 (rank : 21)	θ value	1.69304e-06 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.379420 (rank : 22)	θ value	0.00035302 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
NC score	0.375674 (rank : 23)	θ value	0.0736092 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

KAP1_HUMAN
NC score	0.365823 (rank : 24)	θ value	1.38499e-08 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	58	Shared Neighborhood Hits	26
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.362396 (rank : 25)	θ value	5.26297e-08 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.345997 (rank : 26)	θ value	4.45536e-07 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
NC score	0.344202 (rank : 27)	θ value	4.45536e-07 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	52	Shared Neighborhood Hits	26
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP2_MOUSE
NC score	0.330399 (rank : 28)	θ value	4.92598e-06 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	44	Shared Neighborhood Hits	24
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.328488 (rank : 29)	θ value	2.88788e-06 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	48	Shared Neighborhood Hits	23
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.324089 (rank : 30)	θ value	1.43324e-05 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.323212 (rank : 31)	θ value	1.87187e-05 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

RGDSR_HUMAN
NC score	0.308207 (rank : 32)	θ value	0.163984 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

PREX1_HUMAN
NC score	0.176752 (rank : 33)	θ value	1.69304e-06 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	177	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SH2D3_MOUSE
NC score	0.163617 (rank : 34)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	174	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
NC score	0.154418 (rank : 35)	θ value	0.00102713 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

GP155_HUMAN
NC score	0.123922 (rank : 36)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

CNGB1_HUMAN
NC score	0.101238 (rank : 37)	θ value	0.0563607 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KGP2_HUMAN
NC score	0.088054 (rank : 38)	θ value	3.08544e-08 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	1023	Shared Neighborhood Hits	24
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.087831 (rank : 39)	θ value	6.87365e-08 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	1029	Shared Neighborhood Hits	24
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CNGB3_MOUSE
NC score	0.083191 (rank : 40)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

BCAR3_MOUSE
NC score	0.083146 (rank : 41)	θ value	0.0431538 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

KGP1B_HUMAN
NC score	0.079642 (rank : 42)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	921	Shared Neighborhood Hits	25
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.079588 (rank : 43)	θ value	9.29e-05 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	901	Shared Neighborhood Hits	25
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_MOUSE
NC score	0.079356 (rank : 44)	θ value	9.29e-05 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	922	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CNGB3_HUMAN
NC score	0.073995 (rank : 45)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	206	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

SH23A_HUMAN
NC score	0.065251 (rank : 46)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

CNGA1_HUMAN
NC score	0.062787 (rank : 47)	θ value	0.279714 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	149	Shared Neighborhood Hits	23
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.058551 (rank : 48)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

HCN2_MOUSE
NC score	0.057665 (rank : 49)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	278	Shared Neighborhood Hits	22
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

CNGA2_MOUSE
NC score	0.057647 (rank : 50)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

HCN2_HUMAN
NC score	0.056784 (rank : 51)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	369	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

CNGA3_HUMAN
NC score	0.056207 (rank : 52)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	125	Shared Neighborhood Hits	21
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
NC score	0.055140 (rank : 53)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

FYV1_MOUSE
NC score	0.050931 (rank : 54)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	191	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

BCAR3_HUMAN
NC score	0.050792 (rank : 55)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

NMI_HUMAN
NC score	0.034806 (rank : 56)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q13287, Q53TI8, Q9BVE5	Gene names	NMI
Domain Architecture
Description	N-myc-interactor (Nmi) (N-myc and STAT interactor).

KCNH6_HUMAN
NC score	0.025947 (rank : 57)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	222	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

IRF5_MOUSE
NC score	0.024673 (rank : 58)	θ value	0.47712 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	P56477	Gene names	Irf5
Domain Architecture
Description	Interferon regulatory factor 5 (IRF-5).

PELP1_MOUSE
NC score	0.019168 (rank : 59)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	709	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

CS021_MOUSE
NC score	0.010847 (rank : 60)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D279, Q3UI04	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21 homolog.

AT2A1_HUMAN
NC score	0.010293 (rank : 61)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	O14983, O14984	Gene names	ATP2A1
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

AT2A1_MOUSE
NC score	0.009910 (rank : 62)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R429	Gene names	Atp2a1
Domain Architecture	No domain graphic available
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

AT2A2_HUMAN
NC score	0.009376 (rank : 63)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	P16615, P16614	Gene names	ATP2A2, ATP2B
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8) (Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

AT2A2_MOUSE
NC score	0.009369 (rank : 64)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	O55143, Q9R2A9, Q9WUT5	Gene names	Atp2a2
Domain Architecture
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC 3.6.3.8) (Calcium pump 2) (SERCA2) (SR Ca(2+)-ATPase 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).