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Network neighborhood for query Sequence : HCN3_HUMAN

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HCN3_HUMAN
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HCN1_HUMAN
θ value	0 (rank : 1)	NC score	0.988166 (rank : 3)
Query Neighborhood Hits	99	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	0 (rank : 2)	NC score	0.984889 (rank : 4)
Query Neighborhood Hits	99	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_HUMAN
θ value	0 (rank : 3)	NC score	0.963393 (rank : 8)
Query Neighborhood Hits	99	Target Neighborhood Hits	369	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	0 (rank : 4)	NC score	0.973506 (rank : 5)
Query Neighborhood Hits	99	Target Neighborhood Hits	278	Shared Neighborhood Hits	57
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN3_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
θ value	0 (rank : 6)	NC score	0.996051 (rank : 2)
Query Neighborhood Hits	99	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN4_HUMAN
θ value	0 (rank : 7)	NC score	0.972279 (rank : 6)
Query Neighborhood Hits	99	Target Neighborhood Hits	303	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
θ value	0 (rank : 8)	NC score	0.970621 (rank : 7)
Query Neighborhood Hits	99	Target Neighborhood Hits	284	Shared Neighborhood Hits	57
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

CNGA2_MOUSE
θ value	2.50074e-42 (rank : 9)	NC score	0.863355 (rank : 9)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	41
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_MOUSE
θ value	6.15952e-41 (rank : 10)	NC score	0.850961 (rank : 13)
Query Neighborhood Hits	99	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
θ value	3.05695e-40 (rank : 11)	NC score	0.857233 (rank : 10)
Query Neighborhood Hits	99	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
θ value	6.81017e-40 (rank : 12)	NC score	0.852233 (rank : 11)
Query Neighborhood Hits	99	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
θ value	8.89434e-40 (rank : 13)	NC score	0.851140 (rank : 12)
Query Neighborhood Hits	99	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

KCNH6_HUMAN
θ value	4.41421e-39 (rank : 14)	NC score	0.808384 (rank : 17)
Query Neighborhood Hits	99	Target Neighborhood Hits	222	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH2_HUMAN
θ value	1.28434e-38 (rank : 15)	NC score	0.805448 (rank : 18)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	1.28434e-38 (rank : 16)	NC score	0.804992 (rank : 19)
Query Neighborhood Hits	99	Target Neighborhood Hits	165	Shared Neighborhood Hits	38
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH4_HUMAN
θ value	2.96089e-35 (rank : 17)	NC score	0.794494 (rank : 22)
Query Neighborhood Hits	99	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH7_MOUSE
θ value	2.50655e-34 (rank : 18)	NC score	0.802723 (rank : 20)
Query Neighborhood Hits	99	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH5_HUMAN
θ value	5.584e-34 (rank : 19)	NC score	0.792875 (rank : 24)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	5.584e-34 (rank : 20)	NC score	0.793160 (rank : 23)
Query Neighborhood Hits	99	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

CNGB1_HUMAN
θ value	1.24399e-33 (rank : 21)	NC score	0.825168 (rank : 15)
Query Neighborhood Hits	99	Target Neighborhood Hits	222	Shared Neighborhood Hits	46
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNH7_HUMAN
θ value	8.91499e-32 (rank : 22)	NC score	0.797655 (rank : 21)
Query Neighborhood Hits	99	Target Neighborhood Hits	107	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH1_HUMAN
θ value	1.16434e-31 (rank : 23)	NC score	0.786842 (rank : 27)
Query Neighborhood Hits	99	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	1.16434e-31 (rank : 24)	NC score	0.787013 (rank : 26)
Query Neighborhood Hits	99	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

CNGB3_HUMAN
θ value	1.2049e-28 (rank : 25)	NC score	0.817119 (rank : 16)
Query Neighborhood Hits	99	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
θ value	2.68423e-28 (rank : 26)	NC score	0.832403 (rank : 14)
Query Neighborhood Hits	99	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

KCNH8_HUMAN
θ value	4.57862e-28 (rank : 27)	NC score	0.787354 (rank : 25)
Query Neighborhood Hits	99	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH3_HUMAN
θ value	1.12775e-26 (rank : 28)	NC score	0.776507 (rank : 28)
Query Neighborhood Hits	99	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
θ value	3.28125e-26 (rank : 29)	NC score	0.775828 (rank : 29)
Query Neighborhood Hits	99	Target Neighborhood Hits	133	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KAP0_MOUSE
θ value	8.40245e-06 (rank : 30)	NC score	0.272621 (rank : 31)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
θ value	1.09739e-05 (rank : 31)	NC score	0.301109 (rank : 30)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KGP1A_HUMAN
θ value	0.00175202 (rank : 32)	NC score	0.073341 (rank : 43)
Query Neighborhood Hits	99	Target Neighborhood Hits	901	Shared Neighborhood Hits	47
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.00175202 (rank : 33)	NC score	0.073568 (rank : 41)
Query Neighborhood Hits	99	Target Neighborhood Hits	921	Shared Neighborhood Hits	47
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	0.00175202 (rank : 34)	NC score	0.073562 (rank : 42)
Query Neighborhood Hits	99	Target Neighborhood Hits	922	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KAP1_HUMAN
θ value	0.00509761 (rank : 35)	NC score	0.262815 (rank : 32)
Query Neighborhood Hits	99	Target Neighborhood Hits	58	Shared Neighborhood Hits	35
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	0.00509761 (rank : 36)	NC score	0.259790 (rank : 33)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KGP2_HUMAN
θ value	0.00665767 (rank : 37)	NC score	0.071462 (rank : 44)
Query Neighborhood Hits	99	Target Neighborhood Hits	1023	Shared Neighborhood Hits	39
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	0.00869519 (rank : 38)	NC score	0.071462 (rank : 45)
Query Neighborhood Hits	99	Target Neighborhood Hits	1029	Shared Neighborhood Hits	38
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP2_HUMAN
θ value	0.0148317 (rank : 39)	NC score	0.234621 (rank : 35)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	0.0148317 (rank : 40)	NC score	0.238749 (rank : 34)
Query Neighborhood Hits	99	Target Neighborhood Hits	44	Shared Neighborhood Hits	27
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

NUP53_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.056227 (rank : 54)
Query Neighborhood Hits	99	Target Neighborhood Hits	156	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

MAST1_MOUSE
θ value	0.0563607 (rank : 42)	NC score	0.010106 (rank : 85)
Query Neighborhood Hits	99	Target Neighborhood Hits	1123	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NCOA6_HUMAN
θ value	0.0563607 (rank : 43)	NC score	0.056393 (rank : 53)
Query Neighborhood Hits	99	Target Neighborhood Hits	1202	Shared Neighborhood Hits	36
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

CIZ1_HUMAN
θ value	0.0736092 (rank : 44)	NC score	0.050857 (rank : 61)
Query Neighborhood Hits	99	Target Neighborhood Hits	359	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

BSN_MOUSE
θ value	0.0961366 (rank : 45)	NC score	0.053626 (rank : 58)
Query Neighborhood Hits	99	Target Neighborhood Hits	2057	Shared Neighborhood Hits	39
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

NACAM_MOUSE
θ value	0.0961366 (rank : 46)	NC score	0.055714 (rank : 56)
Query Neighborhood Hits	99	Target Neighborhood Hits	1866	Shared Neighborhood Hits	41
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

BSN_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.035960 (rank : 68)
Query Neighborhood Hits	99	Target Neighborhood Hits	1537	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

KAP3_MOUSE
θ value	0.125558 (rank : 48)	NC score	0.228431 (rank : 36)
Query Neighborhood Hits	99	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
θ value	0.279714 (rank : 49)	NC score	0.222639 (rank : 37)
Query Neighborhood Hits	99	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

ZN219_HUMAN
θ value	0.279714 (rank : 50)	NC score	0.003596 (rank : 105)
Query Neighborhood Hits	99	Target Neighborhood Hits	876	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

ARHG6_HUMAN
θ value	0.365318 (rank : 51)	NC score	0.011734 (rank : 83)
Query Neighborhood Hits	99	Target Neighborhood Hits	376	Shared Neighborhood Hits	3
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

MAGE1_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.040599 (rank : 64)
Query Neighborhood Hits	99	Target Neighborhood Hits	1389	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CCR3_MOUSE
θ value	0.47712 (rank : 53)	NC score	0.015351 (rank : 79)
Query Neighborhood Hits	99	Target Neighborhood Hits	781	Shared Neighborhood Hits	10
SwissProt Accessions	P51678	Gene names	Ccr3, Cmkbr1l2, Cmkbr3
Domain Architecture
Description	Probable C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Macrophage inflammatory protein 1-alpha receptor-like 2) (MIP-1 alpha RL2) (CD193 antigen).

GNAS1_MOUSE
θ value	0.47712 (rank : 54)	NC score	0.014176 (rank : 80)
Query Neighborhood Hits	99	Target Neighborhood Hits	651	Shared Neighborhood Hits	18
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

GP179_HUMAN
θ value	0.47712 (rank : 55)	NC score	0.017511 (rank : 76)
Query Neighborhood Hits	99	Target Neighborhood Hits	372	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

HTRA4_HUMAN
θ value	0.62314 (rank : 56)	NC score	0.037314 (rank : 65)
Query Neighborhood Hits	99	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

CT152_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.147811 (rank : 38)
Query Neighborhood Hits	99	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

ZN318_MOUSE
θ value	0.813845 (rank : 58)	NC score	0.013959 (rank : 81)
Query Neighborhood Hits	99	Target Neighborhood Hits	642	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

KIFC2_HUMAN
θ value	1.06291 (rank : 59)	NC score	0.005422 (rank : 101)
Query Neighborhood Hits	99	Target Neighborhood Hits	237	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

NUP53_MOUSE
θ value	1.06291 (rank : 60)	NC score	0.033652 (rank : 69)
Query Neighborhood Hits	99	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

PDZD2_HUMAN
θ value	1.06291 (rank : 61)	NC score	0.036400 (rank : 66)
Query Neighborhood Hits	99	Target Neighborhood Hits	772	Shared Neighborhood Hits	24
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PRG4_HUMAN
θ value	1.06291 (rank : 62)	NC score	0.019385 (rank : 74)
Query Neighborhood Hits	99	Target Neighborhood Hits	764	Shared Neighborhood Hits	23
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

TMPS9_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.001507 (rank : 110)
Query Neighborhood Hits	99	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

B4GT1_HUMAN
θ value	1.38821 (rank : 64)	NC score	0.020991 (rank : 73)
Query Neighborhood Hits	99	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

SC11A_MOUSE
θ value	1.38821 (rank : 65)	NC score	0.007015 (rank : 93)
Query Neighborhood Hits	99	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

TAAR1_HUMAN
θ value	1.38821 (rank : 66)	NC score	0.003272 (rank : 106)
Query Neighborhood Hits	99	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RJ0, Q3MIH8, Q5VUQ1	Gene names	TAAR1, TA1, TAR1, TRAR1
Domain Architecture
Description	Trace amine-associated receptor 1 (Trace amine receptor 1) (TaR-1).

ARHG6_MOUSE
θ value	1.81305 (rank : 67)	NC score	0.009859 (rank : 86)
Query Neighborhood Hits	99	Target Neighborhood Hits	394	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

AQP7_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.008312 (rank : 88)
Query Neighborhood Hits	99	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O14520, Q5T5L9, Q8NHM3	Gene names	AQP7, AQP7L, AQP9
Domain Architecture
Description	Aquaporin-7 (AQP-7) (Aquaporin-7-like) (Aquaporin adipose) (AQPap).

RPKL1_HUMAN
θ value	2.36792 (rank : 69)	NC score	0.011399 (rank : 84)
Query Neighborhood Hits	99	Target Neighborhood Hits	708	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

ALEX_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.023089 (rank : 72)
Query Neighborhood Hits	99	Target Neighborhood Hits	361	Shared Neighborhood Hits	16
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

CO5A2_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.012328 (rank : 82)
Query Neighborhood Hits	99	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

RECQ4_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.006893 (rank : 95)
Query Neighborhood Hits	99	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

SAPS1_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.042688 (rank : 63)
Query Neighborhood Hits	99	Target Neighborhood Hits	704	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

DAB2P_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.005759 (rank : 100)
Query Neighborhood Hits	99	Target Neighborhood Hits	303	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

GSCR1_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.033278 (rank : 70)
Query Neighborhood Hits	99	Target Neighborhood Hits	674	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MMP11_HUMAN
θ value	4.03905 (rank : 76)	NC score	0.002969 (rank : 107)
Query Neighborhood Hits	99	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

ZSCA1_HUMAN
θ value	4.03905 (rank : 77)	NC score	-0.002034 (rank : 111)
Query Neighborhood Hits	99	Target Neighborhood Hits	724	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

ADA12_MOUSE
θ value	5.27518 (rank : 78)	NC score	0.003815 (rank : 104)
Query Neighborhood Hits	99	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

CO4A3_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.004946 (rank : 102)
Query Neighborhood Hits	99	Target Neighborhood Hits	421	Shared Neighborhood Hits	14
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CU086_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.016489 (rank : 78)
Query Neighborhood Hits	99	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P59089	Gene names	C21orf86
Domain Architecture	No domain graphic available
Description	Protein C21orf86.

DYN3_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.006218 (rank : 98)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

LIME1_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.036098 (rank : 67)
Query Neighborhood Hits	99	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H400, Q5JWJ2, Q6XYB3, Q9NX69	Gene names	LIME1, LIME
Domain Architecture	No domain graphic available
Description	Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule).

TFE3_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.007583 (rank : 92)
Query Neighborhood Hits	99	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TLN1_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.006779 (rank : 97)
Query Neighborhood Hits	99	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	5.27518 (rank : 85)	NC score	0.006786 (rank : 96)
Query Neighborhood Hits	99	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

GCYA2_HUMAN
θ value	6.88961 (rank : 86)	NC score	0.002808 (rank : 108)
Query Neighborhood Hits	99	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

CO039_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.019114 (rank : 75)
Query Neighborhood Hits	99	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

GCF_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.006108 (rank : 99)
Query Neighborhood Hits	99	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P16383, O95032	Gene names	TCF9, C2orf3
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9).

GNDS_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.004831 (rank : 103)
Query Neighborhood Hits	99	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

KCC2B_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.002774 (rank : 109)
Query Neighborhood Hits	99	Target Neighborhood Hits	866	Shared Neighborhood Hits	12
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

NCOA6_MOUSE
θ value	8.99809 (rank : 91)	NC score	0.032376 (rank : 71)
Query Neighborhood Hits	99	Target Neighborhood Hits	1076	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PRD12_HUMAN
θ value	8.99809 (rank : 92)	NC score	-0.003866 (rank : 112)
Query Neighborhood Hits	99	Target Neighborhood Hits	701	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4Q4	Gene names	PRDM12, PFM9
Domain Architecture
Description	PR domain zinc finger protein 12 (PR domain-containing protein 12).

RAI1_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.008125 (rank : 89)
Query Neighborhood Hits	99	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RENT2_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.006950 (rank : 94)
Query Neighborhood Hits	99	Target Neighborhood Hits	618	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

TAF4_HUMAN
θ value	8.99809 (rank : 95)	NC score	0.016717 (rank : 77)
Query Neighborhood Hits	99	Target Neighborhood Hits	687	Shared Neighborhood Hits	24
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TTBK1_HUMAN
θ value	8.99809 (rank : 96)	NC score	0.008494 (rank : 87)
Query Neighborhood Hits	99	Target Neighborhood Hits	1058	Shared Neighborhood Hits	21
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

UTX_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.007677 (rank : 91)
Query Neighborhood Hits	99	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

ZIMP7_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.007762 (rank : 90)
Query Neighborhood Hits	99	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZN669_HUMAN
θ value	8.99809 (rank : 99)	NC score	-0.004469 (rank : 113)
Query Neighborhood Hits	99	Target Neighborhood Hits	746	Shared Neighborhood Hits	5
SwissProt Accessions	Q96BR6, Q5VT39, Q9H9Q6	Gene names	ZNF669
Domain Architecture	No domain graphic available
Description	Zinc finger protein 669.

CT152_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.082055 (rank : 40)
Query Neighborhood Hits	99	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KCNK2_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.061813 (rank : 47)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.061378 (rank : 48)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.059509 (rank : 50)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.057580 (rank : 51)
Query Neighborhood Hits	99	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.051879 (rank : 60)
Query Neighborhood Hits	99	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNK6_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.060002 (rank : 49)
Query Neighborhood Hits	99	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNKA_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.057036 (rank : 52)
Query Neighborhood Hits	99	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNKF_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.063692 (rank : 46)
Query Neighborhood Hits	99	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNKG_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.050323 (rank : 62)
Query Neighborhood Hits	99	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KCNKH_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.095332 (rank : 39)
Query Neighborhood Hits	99	Target Neighborhood Hits	89	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

PRRT3_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.051997 (rank : 59)
Query Neighborhood Hits	99	Target Neighborhood Hits	998	Shared Neighborhood Hits	29
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RPGF4_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.053698 (rank : 57)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.056127 (rank : 55)
Query Neighborhood Hits	99	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

Hits sorted by NC score

HCN3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
NC score	0.996051 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	99	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_HUMAN
NC score	0.988166 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	99	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
NC score	0.984889 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	99	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_MOUSE
NC score	0.973506 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	99	Target Neighborhood Hits	278	Shared Neighborhood Hits	57
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.972279 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	99	Target Neighborhood Hits	303	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.970621 (rank : 7)	θ value	0 (rank : 8)
Query Neighborhood Hits	99	Target Neighborhood Hits	284	Shared Neighborhood Hits	57
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.963393 (rank : 8)	θ value	0 (rank : 3)
Query Neighborhood Hits	99	Target Neighborhood Hits	369	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

CNGA2_MOUSE
NC score	0.863355 (rank : 9)	θ value	2.50074e-42 (rank : 9)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	41
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_MOUSE
NC score	0.857233 (rank : 10)	θ value	3.05695e-40 (rank : 11)
Query Neighborhood Hits	99	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
NC score	0.852233 (rank : 11)	θ value	6.81017e-40 (rank : 12)
Query Neighborhood Hits	99	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.851140 (rank : 12)	θ value	8.89434e-40 (rank : 13)
Query Neighborhood Hits	99	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.850961 (rank : 13)	θ value	6.15952e-41 (rank : 10)
Query Neighborhood Hits	99	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGB3_MOUSE
NC score	0.832403 (rank : 14)	θ value	2.68423e-28 (rank : 26)
Query Neighborhood Hits	99	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB1_HUMAN
NC score	0.825168 (rank : 15)	θ value	1.24399e-33 (rank : 21)
Query Neighborhood Hits	99	Target Neighborhood Hits	222	Shared Neighborhood Hits	46
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_HUMAN
NC score	0.817119 (rank : 16)	θ value	1.2049e-28 (rank : 25)
Query Neighborhood Hits	99	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNH6_HUMAN
NC score	0.808384 (rank : 17)	θ value	4.41421e-39 (rank : 14)
Query Neighborhood Hits	99	Target Neighborhood Hits	222	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH2_HUMAN
NC score	0.805448 (rank : 18)	θ value	1.28434e-38 (rank : 15)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
NC score	0.804992 (rank : 19)	θ value	1.28434e-38 (rank : 16)
Query Neighborhood Hits	99	Target Neighborhood Hits	165	Shared Neighborhood Hits	38
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH7_MOUSE
NC score	0.802723 (rank : 20)	θ value	2.50655e-34 (rank : 18)
Query Neighborhood Hits	99	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH7_HUMAN
NC score	0.797655 (rank : 21)	θ value	8.91499e-32 (rank : 22)
Query Neighborhood Hits	99	Target Neighborhood Hits	107	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH4_HUMAN
NC score	0.794494 (rank : 22)	θ value	2.96089e-35 (rank : 17)
Query Neighborhood Hits	99	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH5_MOUSE
NC score	0.793160 (rank : 23)	θ value	5.584e-34 (rank : 20)
Query Neighborhood Hits	99	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.792875 (rank : 24)	θ value	5.584e-34 (rank : 19)
Query Neighborhood Hits	99	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH8_HUMAN
NC score	0.787354 (rank : 25)	θ value	4.57862e-28 (rank : 27)
Query Neighborhood Hits	99	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH1_MOUSE
NC score	0.787013 (rank : 26)	θ value	1.16434e-31 (rank : 24)
Query Neighborhood Hits	99	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.786842 (rank : 27)	θ value	1.16434e-31 (rank : 23)
Query Neighborhood Hits	99	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH3_HUMAN
NC score	0.776507 (rank : 28)	θ value	1.12775e-26 (rank : 28)
Query Neighborhood Hits	99	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.775828 (rank : 29)	θ value	3.28125e-26 (rank : 29)
Query Neighborhood Hits	99	Target Neighborhood Hits	133	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KAP0_HUMAN
NC score	0.301109 (rank : 30)	θ value	1.09739e-05 (rank : 31)
Query Neighborhood Hits	99	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
NC score	0.272621 (rank : 31)	θ value	8.40245e-06 (rank : 30)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
NC score	0.262815 (rank : 32)	θ value	0.00509761 (rank : 35)
Query Neighborhood Hits	99	Target Neighborhood Hits	58	Shared Neighborhood Hits	35
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.259790 (rank : 33)	θ value	0.00509761 (rank : 36)
Query Neighborhood Hits	99	Target Neighborhood Hits	49	Shared Neighborhood Hits	35
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP2_MOUSE
NC score	0.238749 (rank : 34)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	99	Target Neighborhood Hits	44	Shared Neighborhood Hits	27
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.234621 (rank : 35)	θ value	0.0148317 (rank : 39)
Query Neighborhood Hits	99	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.228431 (rank : 36)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	99	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.222639 (rank : 37)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	99	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

CT152_MOUSE
NC score	0.147811 (rank : 38)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	99	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KCNKH_HUMAN
NC score	0.095332 (rank : 39)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	99	Target Neighborhood Hits	89	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

CT152_HUMAN
NC score	0.082055 (rank : 40)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	99	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KGP1B_HUMAN
NC score	0.073568 (rank : 41)	θ value	0.00175202 (rank : 33)
Query Neighborhood Hits	99	Target Neighborhood Hits	921	Shared Neighborhood Hits	47
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
NC score	0.073562 (rank : 42)	θ value	0.00175202 (rank : 34)
Query Neighborhood Hits	99	Target Neighborhood Hits	922	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.073341 (rank : 43)	θ value	0.00175202 (rank : 32)
Query Neighborhood Hits	99	Target Neighborhood Hits	901	Shared Neighborhood Hits	47
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP2_HUMAN
NC score	0.071462 (rank : 44)	θ value	0.00665767 (rank : 37)
Query Neighborhood Hits	99	Target Neighborhood Hits	1023	Shared Neighborhood Hits	39
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.071462 (rank : 45)	θ value	0.00869519 (rank : 38)
Query Neighborhood Hits	99	Target Neighborhood Hits	1029	Shared Neighborhood Hits	38
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KCNKF_HUMAN
NC score	0.063692 (rank : 46)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	99	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.061813 (rank : 47)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	99	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
NC score	0.061378 (rank : 48)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK6_HUMAN
NC score	0.060002 (rank : 49)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	99	Target Neighborhood Hits	79	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_HUMAN
NC score	0.059509 (rank : 50)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	13
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
NC score	0.057580 (rank : 51)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	99	Target Neighborhood Hits	93	Shared Neighborhood Hits	13
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNKA_HUMAN
NC score	0.057036 (rank : 52)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	99	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

NCOA6_HUMAN
NC score	0.056393 (rank : 53)	θ value	0.0563607 (rank : 43)
Query Neighborhood Hits	99	Target Neighborhood Hits	1202	Shared Neighborhood Hits	36
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NUP53_HUMAN
NC score	0.056227 (rank : 54)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	99	Target Neighborhood Hits	156	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

RPGF4_MOUSE
NC score	0.056127 (rank : 55)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	99	Target Neighborhood Hits	80	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

NACAM_MOUSE
NC score	0.055714 (rank : 56)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	99	Target Neighborhood Hits	1866	Shared Neighborhood Hits	41
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RPGF4_HUMAN
NC score	0.053698 (rank : 57)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	99	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

BSN_MOUSE
NC score	0.053626 (rank : 58)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	99	Target Neighborhood Hits	2057	Shared Neighborhood Hits	39
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PRRT3_HUMAN
NC score	0.051997 (rank : 59)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	99	Target Neighborhood Hits	998	Shared Neighborhood Hits	29
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

KCNK4_HUMAN
NC score	0.051879 (rank : 60)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	99	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

CIZ1_HUMAN
NC score	0.050857 (rank : 61)	θ value	0.0736092 (rank : 44)
Query Neighborhood Hits	99	Target Neighborhood Hits	359	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

KCNKG_HUMAN
NC score	0.050323 (rank : 62)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	99	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

SAPS1_HUMAN
NC score	0.042688 (rank : 63)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	99	Target Neighborhood Hits	704	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

MAGE1_HUMAN
NC score	0.040599 (rank : 64)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	99	Target Neighborhood Hits	1389	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

HTRA4_HUMAN
NC score	0.037314 (rank : 65)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	99	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

PDZD2_HUMAN
NC score	0.036400 (rank : 66)	θ value	1.06291 (rank : 61)
Query Neighborhood Hits	99	Target Neighborhood Hits	772	Shared Neighborhood Hits	24
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

LIME1_HUMAN
NC score	0.036098 (rank : 67)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	99	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H400, Q5JWJ2, Q6XYB3, Q9NX69	Gene names	LIME1, LIME
Domain Architecture	No domain graphic available
Description	Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule).

BSN_HUMAN
NC score	0.035960 (rank : 68)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	99	Target Neighborhood Hits	1537	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

NUP53_MOUSE
NC score	0.033652 (rank : 69)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	99	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

GSCR1_HUMAN
NC score	0.033278 (rank : 70)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	99	Target Neighborhood Hits	674	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

NCOA6_MOUSE
NC score	0.032376 (rank : 71)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	99	Target Neighborhood Hits	1076	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ALEX_HUMAN
NC score	0.023089 (rank : 72)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	99	Target Neighborhood Hits	361	Shared Neighborhood Hits	16
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

B4GT1_HUMAN
NC score	0.020991 (rank : 73)	θ value	1.38821 (rank : 64)
Query Neighborhood Hits	99	Target Neighborhood Hits	168	Shared Neighborhood Hits	9
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

PRG4_HUMAN
NC score	0.019385 (rank : 74)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	99	Target Neighborhood Hits	764	Shared Neighborhood Hits	23
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CO039_MOUSE
NC score	0.019114 (rank : 75)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	99	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

GP179_HUMAN
NC score	0.017511 (rank : 76)	θ value	0.47712 (rank : 55)
Query Neighborhood Hits	99	Target Neighborhood Hits	372	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PRD1	Gene names	GPR179, GPR158L1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 179 precursor (Probable G-protein coupled receptor 158-like 1).

TAF4_HUMAN
NC score	0.016717 (rank : 77)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	99	Target Neighborhood Hits	687	Shared Neighborhood Hits	24
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

CU086_HUMAN
NC score	0.016489 (rank : 78)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	99	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P59089	Gene names	C21orf86
Domain Architecture	No domain graphic available
Description	Protein C21orf86.

CCR3_MOUSE
NC score	0.015351 (rank : 79)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	99	Target Neighborhood Hits	781	Shared Neighborhood Hits	10
SwissProt Accessions	P51678	Gene names	Ccr3, Cmkbr1l2, Cmkbr3
Domain Architecture
Description	Probable C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Macrophage inflammatory protein 1-alpha receptor-like 2) (MIP-1 alpha RL2) (CD193 antigen).

GNAS1_MOUSE
NC score	0.014176 (rank : 80)	θ value	0.47712 (rank : 54)
Query Neighborhood Hits	99	Target Neighborhood Hits	651	Shared Neighborhood Hits	18
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

ZN318_MOUSE
NC score	0.013959 (rank : 81)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	99	Target Neighborhood Hits	642	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

CO5A2_HUMAN
NC score	0.012328 (rank : 82)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	99	Target Neighborhood Hits	760	Shared Neighborhood Hits	17
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

ARHG6_HUMAN
NC score	0.011734 (rank : 83)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	99	Target Neighborhood Hits	376	Shared Neighborhood Hits	3
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RPKL1_HUMAN
NC score	0.011399 (rank : 84)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	99	Target Neighborhood Hits	708	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.010106 (rank : 85)	θ value	0.0563607 (rank : 42)
Query Neighborhood Hits	99	Target Neighborhood Hits	1123	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ARHG6_MOUSE
NC score	0.009859 (rank : 86)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	99	Target Neighborhood Hits	394	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

TTBK1_HUMAN
NC score	0.008494 (rank : 87)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	99	Target Neighborhood Hits	1058	Shared Neighborhood Hits	21
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

AQP7_HUMAN
NC score	0.008312 (rank : 88)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	99	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O14520, Q5T5L9, Q8NHM3	Gene names	AQP7, AQP7L, AQP9
Domain Architecture
Description	Aquaporin-7 (AQP-7) (Aquaporin-7-like) (Aquaporin adipose) (AQPap).

RAI1_HUMAN
NC score	0.008125 (rank : 89)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	99	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

ZIMP7_HUMAN
NC score	0.007762 (rank : 90)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	99	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

UTX_HUMAN
NC score	0.007677 (rank : 91)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	99	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

TFE3_HUMAN
NC score	0.007583 (rank : 92)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	99	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

SC11A_MOUSE
NC score	0.007015 (rank : 93)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	99	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

RENT2_HUMAN
NC score	0.006950 (rank : 94)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	99	Target Neighborhood Hits	618	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RECQ4_MOUSE
NC score	0.006893 (rank : 95)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	99	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

TLN1_MOUSE
NC score	0.006786 (rank : 96)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	99	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN1_HUMAN
NC score	0.006779 (rank : 97)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	99	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

DYN3_HUMAN
NC score	0.006218 (rank : 98)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	99	Target Neighborhood Hits	158	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GCF_HUMAN
NC score	0.006108 (rank : 99)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	99	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P16383, O95032	Gene names	TCF9, C2orf3
Domain Architecture	No domain graphic available
Description	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9).

DAB2P_HUMAN
NC score	0.005759 (rank : 100)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	99	Target Neighborhood Hits	303	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

KIFC2_HUMAN
NC score	0.005422 (rank : 101)	θ value	1.06291 (rank : 59)
Query Neighborhood Hits	99	Target Neighborhood Hits	237	Shared Neighborhood Hits	7
SwissProt Accessions	Q96AC6	Gene names	KIFC2
Domain Architecture
Description	Kinesin-like protein KIFC2.

CO4A3_HUMAN
NC score	0.004946 (rank : 102)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	99	Target Neighborhood Hits	421	Shared Neighborhood Hits	14
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

GNDS_HUMAN
NC score	0.004831 (rank : 103)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	99	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

ADA12_MOUSE
NC score	0.003815 (rank : 104)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	99	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ZN219_HUMAN
NC score	0.003596 (rank : 105)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	99	Target Neighborhood Hits	876	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

TAAR1_HUMAN
NC score	0.003272 (rank : 106)	θ value	1.38821 (rank : 66)
Query Neighborhood Hits	99	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RJ0, Q3MIH8, Q5VUQ1	Gene names	TAAR1, TA1, TAR1, TRAR1
Domain Architecture
Description	Trace amine-associated receptor 1 (Trace amine receptor 1) (TaR-1).

MMP11_HUMAN
NC score	0.002969 (rank : 107)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	99	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

GCYA2_HUMAN
NC score	0.002808 (rank : 108)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	99	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

KCC2B_HUMAN
NC score	0.002774 (rank : 109)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	99	Target Neighborhood Hits	866	Shared Neighborhood Hits	12
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

TMPS9_HUMAN
NC score	0.001507 (rank : 110)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	99	Target Neighborhood Hits	276	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z410, Q6ZND6, Q7Z411	Gene names	TMPRSS9
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 9 (EC 3.4.21.-) (Polyserase-1) (Polyserase-I) (Polyserine protease 1) [Contains: Serase-1; Serase-2; Serase-3].

ZSCA1_HUMAN
NC score	-0.002034 (rank : 111)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	99	Target Neighborhood Hits	724	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NBB4, Q6WLH8, Q86WS8	Gene names	ZSCAN1
Domain Architecture	No domain graphic available
Description	Zinc finger and SCAN domain-containing protein 1.

PRD12_HUMAN
NC score	-0.003866 (rank : 112)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	99	Target Neighborhood Hits	701	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H4Q4	Gene names	PRDM12, PFM9
Domain Architecture
Description	PR domain zinc finger protein 12 (PR domain-containing protein 12).

ZN669_HUMAN
NC score	-0.004469 (rank : 113)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	99	Target Neighborhood Hits	746	Shared Neighborhood Hits	5
SwissProt Accessions	Q96BR6, Q5VT39, Q9H9Q6	Gene names	ZNF669
Domain Architecture	No domain graphic available
Description	Zinc finger protein 669.