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Network neighborhood for query Sequence : APBA3_HUMAN

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APBA3_HUMAN
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APBA3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	201	Target Neighborhood Hits	201	Shared Neighborhood Hits	201
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	0 (rank : 2)	NC score	0.976153 (rank : 2)
Query Neighborhood Hits	201	Target Neighborhood Hits	174	Shared Neighborhood Hits	143
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA1_HUMAN
θ value	3.62588e-142 (rank : 3)	NC score	0.938851 (rank : 5)
Query Neighborhood Hits	201	Target Neighborhood Hits	325	Shared Neighborhood Hits	143
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_MOUSE
θ value	2.0589e-137 (rank : 4)	NC score	0.949553 (rank : 3)
Query Neighborhood Hits	201	Target Neighborhood Hits	219	Shared Neighborhood Hits	140
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
θ value	2.51683e-135 (rank : 5)	NC score	0.948590 (rank : 4)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	137
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SDCB2_HUMAN
θ value	1.133e-10 (rank : 6)	NC score	0.523936 (rank : 7)
Query Neighborhood Hits	201	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_MOUSE
θ value	1.133e-10 (rank : 7)	NC score	0.525076 (rank : 6)
Query Neighborhood Hits	201	Target Neighborhood Hits	118	Shared Neighborhood Hits	90
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB1_MOUSE
θ value	2.36244e-08 (rank : 8)	NC score	0.507145 (rank : 9)
Query Neighborhood Hits	201	Target Neighborhood Hits	144	Shared Neighborhood Hits	103
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB1_HUMAN
θ value	5.26297e-08 (rank : 9)	NC score	0.514381 (rank : 8)
Query Neighborhood Hits	201	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

CSKP_MOUSE
θ value	2.21117e-06 (rank : 10)	NC score	0.131616 (rank : 156)
Query Neighborhood Hits	201	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

MPDZ_HUMAN
θ value	2.21117e-06 (rank : 11)	NC score	0.465369 (rank : 12)
Query Neighborhood Hits	201	Target Neighborhood Hits	261	Shared Neighborhood Hits	147
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MAGI2_MOUSE
θ value	2.88788e-06 (rank : 12)	NC score	0.428503 (rank : 28)
Query Neighborhood Hits	201	Target Neighborhood Hits	370	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

INADL_HUMAN
θ value	3.77169e-06 (rank : 13)	NC score	0.462940 (rank : 13)
Query Neighborhood Hits	201	Target Neighborhood Hits	260	Shared Neighborhood Hits	138
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

MAGI1_MOUSE
θ value	4.92598e-06 (rank : 14)	NC score	0.436246 (rank : 23)
Query Neighborhood Hits	201	Target Neighborhood Hits	403	Shared Neighborhood Hits	148
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	4.92598e-06 (rank : 15)	NC score	0.429199 (rank : 27)
Query Neighborhood Hits	201	Target Neighborhood Hits	373	Shared Neighborhood Hits	143
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

GRIP1_HUMAN
θ value	8.40245e-06 (rank : 16)	NC score	0.465467 (rank : 11)
Query Neighborhood Hits	201	Target Neighborhood Hits	231	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	8.40245e-06 (rank : 17)	NC score	0.465942 (rank : 10)
Query Neighborhood Hits	201	Target Neighborhood Hits	241	Shared Neighborhood Hits	142
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

CSKP_HUMAN
θ value	1.43324e-05 (rank : 18)	NC score	0.131568 (rank : 157)
Query Neighborhood Hits	201	Target Neighborhood Hits	1022	Shared Neighborhood Hits	111
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

K1849_HUMAN
θ value	1.43324e-05 (rank : 19)	NC score	0.372764 (rank : 52)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	114
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LAP4_HUMAN
θ value	1.43324e-05 (rank : 20)	NC score	0.282188 (rank : 90)
Query Neighborhood Hits	201	Target Neighborhood Hits	608	Shared Neighborhood Hits	155
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

NOS1_HUMAN
θ value	1.43324e-05 (rank : 21)	NC score	0.261807 (rank : 105)
Query Neighborhood Hits	201	Target Neighborhood Hits	218	Shared Neighborhood Hits	106
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

MAGI1_HUMAN
θ value	1.87187e-05 (rank : 22)	NC score	0.432295 (rank : 24)
Query Neighborhood Hits	201	Target Neighborhood Hits	388	Shared Neighborhood Hits	148
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

EM55_HUMAN
θ value	4.1701e-05 (rank : 23)	NC score	0.362924 (rank : 60)
Query Neighborhood Hits	201	Target Neighborhood Hits	228	Shared Neighborhood Hits	115
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	4.1701e-05 (rank : 24)	NC score	0.362769 (rank : 61)
Query Neighborhood Hits	201	Target Neighborhood Hits	221	Shared Neighborhood Hits	115
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

LAP4_MOUSE
θ value	5.44631e-05 (rank : 25)	NC score	0.275747 (rank : 93)
Query Neighborhood Hits	201	Target Neighborhood Hits	590	Shared Neighborhood Hits	149
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

USH1C_MOUSE
θ value	5.44631e-05 (rank : 26)	NC score	0.417102 (rank : 32)
Query Neighborhood Hits	201	Target Neighborhood Hits	557	Shared Neighborhood Hits	143
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GRIP2_HUMAN
θ value	9.29e-05 (rank : 27)	NC score	0.459156 (rank : 14)
Query Neighborhood Hits	201	Target Neighborhood Hits	256	Shared Neighborhood Hits	143
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

INADL_MOUSE
θ value	9.29e-05 (rank : 28)	NC score	0.453132 (rank : 16)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	141
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LIN7C_HUMAN
θ value	9.29e-05 (rank : 29)	NC score	0.452040 (rank : 17)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	9.29e-05 (rank : 30)	NC score	0.452040 (rank : 18)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

NOS1_MOUSE
θ value	9.29e-05 (rank : 31)	NC score	0.236798 (rank : 112)
Query Neighborhood Hits	201	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

DLG5_HUMAN
θ value	0.000158464 (rank : 32)	NC score	0.270389 (rank : 97)
Query Neighborhood Hits	201	Target Neighborhood Hits	1088	Shared Neighborhood Hits	134
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

MPDZ_MOUSE
θ value	0.000158464 (rank : 33)	NC score	0.453399 (rank : 15)
Query Neighborhood Hits	201	Target Neighborhood Hits	298	Shared Neighborhood Hits	144
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MPP2_MOUSE
θ value	0.000158464 (rank : 34)	NC score	0.321333 (rank : 71)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

NEB2_HUMAN
θ value	0.00020696 (rank : 35)	NC score	0.291133 (rank : 87)
Query Neighborhood Hits	201	Target Neighborhood Hits	883	Shared Neighborhood Hits	107
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	0.00020696 (rank : 36)	NC score	0.287173 (rank : 88)
Query Neighborhood Hits	201	Target Neighborhood Hits	889	Shared Neighborhood Hits	108
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

LIN7B_HUMAN
θ value	0.000270298 (rank : 37)	NC score	0.444484 (rank : 19)
Query Neighborhood Hits	201	Target Neighborhood Hits	200	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MPP2_HUMAN
θ value	0.000270298 (rank : 38)	NC score	0.315495 (rank : 75)
Query Neighborhood Hits	201	Target Neighborhood Hits	173	Shared Neighborhood Hits	85
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PAR3L_HUMAN
θ value	0.000270298 (rank : 39)	NC score	0.431738 (rank : 26)
Query Neighborhood Hits	201	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

LIN7B_MOUSE
θ value	0.00035302 (rank : 40)	NC score	0.441992 (rank : 20)
Query Neighborhood Hits	201	Target Neighborhood Hits	200	Shared Neighborhood Hits	131
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

DLG3_HUMAN
θ value	0.000461057 (rank : 41)	NC score	0.421180 (rank : 31)
Query Neighborhood Hits	201	Target Neighborhood Hits	269	Shared Neighborhood Hits	130
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	0.000461057 (rank : 42)	NC score	0.422677 (rank : 30)
Query Neighborhood Hits	201	Target Neighborhood Hits	274	Shared Neighborhood Hits	131
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

USH1C_HUMAN
θ value	0.000461057 (rank : 43)	NC score	0.432278 (rank : 25)
Query Neighborhood Hits	201	Target Neighborhood Hits	327	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

LIN7A_HUMAN
θ value	0.000786445 (rank : 44)	NC score	0.441324 (rank : 22)
Query Neighborhood Hits	201	Target Neighborhood Hits	193	Shared Neighborhood Hits	133
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	0.000786445 (rank : 45)	NC score	0.441547 (rank : 21)
Query Neighborhood Hits	201	Target Neighborhood Hits	193	Shared Neighborhood Hits	133
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

PDZD1_MOUSE
θ value	0.000786445 (rank : 46)	NC score	0.415557 (rank : 33)
Query Neighborhood Hits	201	Target Neighborhood Hits	191	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MPP4_HUMAN
θ value	0.00134147 (rank : 47)	NC score	0.385481 (rank : 48)
Query Neighborhood Hits	201	Target Neighborhood Hits	205	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

SHAN1_HUMAN
θ value	0.00134147 (rank : 48)	NC score	0.183258 (rank : 137)
Query Neighborhood Hits	201	Target Neighborhood Hits	1041	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PARD3_HUMAN
θ value	0.00175202 (rank : 49)	NC score	0.411123 (rank : 37)
Query Neighborhood Hits	201	Target Neighborhood Hits	312	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PDZD2_HUMAN
θ value	0.00175202 (rank : 50)	NC score	0.387650 (rank : 46)
Query Neighborhood Hits	201	Target Neighborhood Hits	772	Shared Neighborhood Hits	144
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

K1849_MOUSE
θ value	0.00298849 (rank : 51)	NC score	0.339265 (rank : 67)
Query Neighborhood Hits	201	Target Neighborhood Hits	335	Shared Neighborhood Hits	118
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MPP6_HUMAN
θ value	0.00390308 (rank : 52)	NC score	0.318905 (rank : 73)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

PARD3_MOUSE
θ value	0.00390308 (rank : 53)	NC score	0.410489 (rank : 39)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	133
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

LNX1_HUMAN
θ value	0.00509761 (rank : 54)	NC score	0.383028 (rank : 49)
Query Neighborhood Hits	201	Target Neighborhood Hits	379	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MPP4_MOUSE
θ value	0.00509761 (rank : 55)	NC score	0.362154 (rank : 62)
Query Neighborhood Hits	201	Target Neighborhood Hits	188	Shared Neighborhood Hits	108
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP6_MOUSE
θ value	0.00509761 (rank : 56)	NC score	0.319908 (rank : 72)
Query Neighborhood Hits	201	Target Neighborhood Hits	187	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PDZD3_HUMAN
θ value	0.00509761 (rank : 57)	NC score	0.386226 (rank : 47)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD7_HUMAN
θ value	0.00509761 (rank : 58)	NC score	0.427908 (rank : 29)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

WHRN_HUMAN
θ value	0.00509761 (rank : 59)	NC score	0.399982 (rank : 42)
Query Neighborhood Hits	201	Target Neighborhood Hits	325	Shared Neighborhood Hits	137
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	0.00509761 (rank : 60)	NC score	0.396106 (rank : 44)
Query Neighborhood Hits	201	Target Neighborhood Hits	412	Shared Neighborhood Hits	138
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

GOPC_HUMAN
θ value	0.00665767 (rank : 61)	NC score	0.391465 (rank : 45)
Query Neighborhood Hits	201	Target Neighborhood Hits	377	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.00665767 (rank : 62)	NC score	0.397027 (rank : 43)
Query Neighborhood Hits	201	Target Neighborhood Hits	323	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

LNX1_MOUSE
θ value	0.00665767 (rank : 63)	NC score	0.380177 (rank : 50)
Query Neighborhood Hits	201	Target Neighborhood Hits	377	Shared Neighborhood Hits	131
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

MPP3_HUMAN
θ value	0.00665767 (rank : 64)	NC score	0.368662 (rank : 54)
Query Neighborhood Hits	201	Target Neighborhood Hits	171	Shared Neighborhood Hits	119
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	0.00665767 (rank : 65)	NC score	0.371094 (rank : 53)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	118
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

NEB1_HUMAN
θ value	0.00665767 (rank : 66)	NC score	0.293447 (rank : 85)
Query Neighborhood Hits	201	Target Neighborhood Hits	829	Shared Neighborhood Hits	119
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PTN13_MOUSE
θ value	0.00665767 (rank : 67)	NC score	0.236177 (rank : 114)
Query Neighborhood Hits	201	Target Neighborhood Hits	426	Shared Neighborhood Hits	139
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SHC3_HUMAN
θ value	0.00665767 (rank : 68)	NC score	0.147055 (rank : 148)
Query Neighborhood Hits	201	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

LNX2_HUMAN
θ value	0.00869519 (rank : 69)	NC score	0.368540 (rank : 55)
Query Neighborhood Hits	201	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

SHC3_MOUSE
θ value	0.00869519 (rank : 70)	NC score	0.144443 (rank : 151)
Query Neighborhood Hits	201	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

MAST3_HUMAN
θ value	0.0113563 (rank : 71)	NC score	0.067504 (rank : 198)
Query Neighborhood Hits	201	Target Neighborhood Hits	1128	Shared Neighborhood Hits	107
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PTN13_HUMAN
θ value	0.0113563 (rank : 72)	NC score	0.238995 (rank : 111)
Query Neighborhood Hits	201	Target Neighborhood Hits	471	Shared Neighborhood Hits	144
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

AFAD_HUMAN
θ value	0.0148317 (rank : 73)	NC score	0.303447 (rank : 83)
Query Neighborhood Hits	201	Target Neighborhood Hits	689	Shared Neighborhood Hits	119
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

MPP5_MOUSE
θ value	0.0148317 (rank : 74)	NC score	0.349289 (rank : 66)
Query Neighborhood Hits	201	Target Neighborhood Hits	226	Shared Neighborhood Hits	112
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MAST4_HUMAN
θ value	0.0193708 (rank : 75)	NC score	0.060683 (rank : 204)
Query Neighborhood Hits	201	Target Neighborhood Hits	1804	Shared Neighborhood Hits	116
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SNTB2_MOUSE
θ value	0.0252991 (rank : 76)	NC score	0.318546 (rank : 74)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	116
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

MAST2_HUMAN
θ value	0.0330416 (rank : 77)	NC score	0.060803 (rank : 203)
Query Neighborhood Hits	201	Target Neighborhood Hits	1189	Shared Neighborhood Hits	101
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	0.0330416 (rank : 78)	NC score	0.059350 (rank : 206)
Query Neighborhood Hits	201	Target Neighborhood Hits	1110	Shared Neighborhood Hits	96
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PDZD3_MOUSE
θ value	0.0431538 (rank : 79)	NC score	0.363715 (rank : 58)
Query Neighborhood Hits	201	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

LNX2_MOUSE
θ value	0.0563607 (rank : 80)	NC score	0.364585 (rank : 57)
Query Neighborhood Hits	201	Target Neighborhood Hits	407	Shared Neighborhood Hits	128
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PICK1_HUMAN
θ value	0.0563607 (rank : 81)	NC score	0.314198 (rank : 76)
Query Neighborhood Hits	201	Target Neighborhood Hits	132	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	0.0563607 (rank : 82)	NC score	0.313631 (rank : 78)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	98
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SHAN2_HUMAN
θ value	0.0736092 (rank : 83)	NC score	0.253895 (rank : 109)
Query Neighborhood Hits	201	Target Neighborhood Hits	346	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	0.0736092 (rank : 84)	NC score	0.234012 (rank : 115)
Query Neighborhood Hits	201	Target Neighborhood Hits	446	Shared Neighborhood Hits	110
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SI1L3_HUMAN
θ value	0.0736092 (rank : 85)	NC score	0.125528 (rank : 162)
Query Neighborhood Hits	201	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SNTB2_HUMAN
θ value	0.0736092 (rank : 86)	NC score	0.313790 (rank : 77)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	116
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PER2_HUMAN
θ value	0.0961366 (rank : 87)	NC score	0.026845 (rank : 225)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

SHC1_HUMAN
θ value	0.0961366 (rank : 88)	NC score	0.126940 (rank : 159)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	0.0961366 (rank : 89)	NC score	0.125648 (rank : 161)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SI1L2_HUMAN
θ value	0.0961366 (rank : 90)	NC score	0.127390 (rank : 158)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	0.0961366 (rank : 91)	NC score	0.125323 (rank : 163)
Query Neighborhood Hits	201	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

ZO1_HUMAN
θ value	0.0961366 (rank : 92)	NC score	0.278015 (rank : 92)
Query Neighborhood Hits	201	Target Neighborhood Hits	474	Shared Neighborhood Hits	128
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	0.0961366 (rank : 93)	NC score	0.281986 (rank : 91)
Query Neighborhood Hits	201	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ARHGB_HUMAN
θ value	0.125558 (rank : 94)	NC score	0.220838 (rank : 121)
Query Neighborhood Hits	201	Target Neighborhood Hits	375	Shared Neighborhood Hits	122
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DLG1_HUMAN
θ value	0.125558 (rank : 95)	NC score	0.404935 (rank : 40)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	122
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	0.125558 (rank : 96)	NC score	0.403343 (rank : 41)
Query Neighborhood Hits	201	Target Neighborhood Hits	285	Shared Neighborhood Hits	123
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

PDZD1_HUMAN
θ value	0.125558 (rank : 97)	NC score	0.374534 (rank : 51)
Query Neighborhood Hits	201	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PREX1_HUMAN
θ value	0.125558 (rank : 98)	NC score	0.069546 (rank : 196)
Query Neighborhood Hits	201	Target Neighborhood Hits	177	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

DLG2_HUMAN
θ value	0.163984 (rank : 99)	NC score	0.411960 (rank : 36)
Query Neighborhood Hits	201	Target Neighborhood Hits	279	Shared Neighborhood Hits	132
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	0.163984 (rank : 100)	NC score	0.410553 (rank : 38)
Query Neighborhood Hits	201	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MAST1_HUMAN
θ value	0.163984 (rank : 101)	NC score	0.060513 (rank : 205)
Query Neighborhood Hits	201	Target Neighborhood Hits	1146	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.163984 (rank : 102)	NC score	0.061425 (rank : 202)
Query Neighborhood Hits	201	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MPP5_HUMAN
θ value	0.163984 (rank : 103)	NC score	0.349442 (rank : 65)
Query Neighborhood Hits	201	Target Neighborhood Hits	231	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

RGS3_HUMAN
θ value	0.163984 (rank : 104)	NC score	0.054504 (rank : 211)
Query Neighborhood Hits	201	Target Neighborhood Hits	1375	Shared Neighborhood Hits	78
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SUCA_HUMAN
θ value	0.163984 (rank : 105)	NC score	0.055425 (rank : 210)
Query Neighborhood Hits	201	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

ZIMP7_MOUSE
θ value	0.163984 (rank : 106)	NC score	0.026721 (rank : 226)
Query Neighborhood Hits	201	Target Neighborhood Hits	566	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

DLG4_HUMAN
θ value	0.21417 (rank : 107)	NC score	0.413959 (rank : 35)
Query Neighborhood Hits	201	Target Neighborhood Hits	286	Shared Neighborhood Hits	131
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.21417 (rank : 108)	NC score	0.414486 (rank : 34)
Query Neighborhood Hits	201	Target Neighborhood Hits	282	Shared Neighborhood Hits	133
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

SI1L1_HUMAN
θ value	0.21417 (rank : 109)	NC score	0.120032 (rank : 165)
Query Neighborhood Hits	201	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	0.21417 (rank : 110)	NC score	0.120198 (rank : 164)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

JIP1_HUMAN
θ value	0.279714 (rank : 111)	NC score	0.092714 (rank : 177)
Query Neighborhood Hits	201	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NHERF_HUMAN
θ value	0.279714 (rank : 112)	NC score	0.350879 (rank : 64)
Query Neighborhood Hits	201	Target Neighborhood Hits	190	Shared Neighborhood Hits	115
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	0.279714 (rank : 113)	NC score	0.363285 (rank : 59)
Query Neighborhood Hits	201	Target Neighborhood Hits	195	Shared Neighborhood Hits	116
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

GIPC2_HUMAN
θ value	0.365318 (rank : 114)	NC score	0.194032 (rank : 129)
Query Neighborhood Hits	201	Target Neighborhood Hits	93	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

ARHGC_HUMAN
θ value	0.47712 (rank : 115)	NC score	0.204319 (rank : 123)
Query Neighborhood Hits	201	Target Neighborhood Hits	351	Shared Neighborhood Hits	116
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	0.47712 (rank : 116)	NC score	0.201602 (rank : 124)
Query Neighborhood Hits	201	Target Neighborhood Hits	344	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

JIP1_MOUSE
θ value	0.47712 (rank : 117)	NC score	0.090172 (rank : 181)
Query Neighborhood Hits	201	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NHRF2_HUMAN
θ value	0.47712 (rank : 118)	NC score	0.368132 (rank : 56)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	127
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

OGFR_MOUSE
θ value	0.47712 (rank : 119)	NC score	0.024819 (rank : 231)
Query Neighborhood Hits	201	Target Neighborhood Hits	584	Shared Neighborhood Hits	22
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PAR6A_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.261559 (rank : 106)
Query Neighborhood Hits	201	Target Neighborhood Hits	119	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.262597 (rank : 104)
Query Neighborhood Hits	201	Target Neighborhood Hits	115	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

ATBF1_MOUSE
θ value	0.62314 (rank : 122)	NC score	0.009418 (rank : 256)
Query Neighborhood Hits	201	Target Neighborhood Hits	1841	Shared Neighborhood Hits	34
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

GIPC1_MOUSE
θ value	0.62314 (rank : 123)	NC score	0.208779 (rank : 122)
Query Neighborhood Hits	201	Target Neighborhood Hits	92	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC3_HUMAN
θ value	0.62314 (rank : 124)	NC score	0.139450 (rank : 152)
Query Neighborhood Hits	201	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	0.62314 (rank : 125)	NC score	0.137035 (rank : 154)
Query Neighborhood Hits	201	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

LIMK2_MOUSE
θ value	0.62314 (rank : 126)	NC score	0.024474 (rank : 232)
Query Neighborhood Hits	201	Target Neighborhood Hits	998	Shared Neighborhood Hits	56
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MAGE1_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.025372 (rank : 227)
Query Neighborhood Hits	201	Target Neighborhood Hits	1389	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SUCA_MOUSE
θ value	0.62314 (rank : 128)	NC score	0.049406 (rank : 217)
Query Neighborhood Hits	201	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

BSN_MOUSE
θ value	0.813845 (rank : 129)	NC score	0.037488 (rank : 221)
Query Neighborhood Hits	201	Target Neighborhood Hits	2057	Shared Neighborhood Hits	55
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

GIPC2_MOUSE
θ value	0.813845 (rank : 130)	NC score	0.137937 (rank : 153)
Query Neighborhood Hits	201	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

NHRF2_MOUSE
θ value	0.813845 (rank : 131)	NC score	0.357105 (rank : 63)
Query Neighborhood Hits	201	Target Neighborhood Hits	194	Shared Neighborhood Hits	127
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PZRN3_MOUSE
θ value	0.813845 (rank : 132)	NC score	0.265126 (rank : 102)
Query Neighborhood Hits	201	Target Neighborhood Hits	447	Shared Neighborhood Hits	117
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RGS3_MOUSE
θ value	0.813845 (rank : 133)	NC score	0.058586 (rank : 208)
Query Neighborhood Hits	201	Target Neighborhood Hits	1621	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TBC10_MOUSE
θ value	0.813845 (rank : 134)	NC score	0.020979 (rank : 238)
Query Neighborhood Hits	201	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

TIAM1_HUMAN
θ value	0.813845 (rank : 135)	NC score	0.073593 (rank : 194)
Query Neighborhood Hits	201	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ANR25_MOUSE
θ value	1.06291 (rank : 136)	NC score	0.012471 (rank : 252)
Query Neighborhood Hits	201	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ARH_HUMAN
θ value	1.06291 (rank : 137)	NC score	0.035523 (rank : 222)
Query Neighborhood Hits	201	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

FGD1_MOUSE
θ value	1.06291 (rank : 138)	NC score	0.020899 (rank : 239)
Query Neighborhood Hits	201	Target Neighborhood Hits	387	Shared Neighborhood Hits	22
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MY18A_MOUSE
θ value	1.06291 (rank : 139)	NC score	0.050483 (rank : 216)
Query Neighborhood Hits	201	Target Neighborhood Hits	1989	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

ZO3_MOUSE
θ value	1.06291 (rank : 140)	NC score	0.308996 (rank : 80)
Query Neighborhood Hits	201	Target Neighborhood Hits	224	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

DGUOK_HUMAN
θ value	1.38821 (rank : 141)	NC score	0.019723 (rank : 241)
Query Neighborhood Hits	201	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q16854, P78532, Q16759, Q96BC1	Gene names	DGUOK, DGK
Domain Architecture
Description	Deoxyguanosine kinase, mitochondrial precursor (EC 2.7.1.113) (dGK).

GIPC1_HUMAN
θ value	1.38821 (rank : 142)	NC score	0.187037 (rank : 133)
Query Neighborhood Hits	201	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

LIMK2_HUMAN
θ value	1.38821 (rank : 143)	NC score	0.022781 (rank : 233)
Query Neighborhood Hits	201	Target Neighborhood Hits	986	Shared Neighborhood Hits	56
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

PCLO_MOUSE
θ value	1.38821 (rank : 144)	NC score	0.114219 (rank : 169)
Query Neighborhood Hits	201	Target Neighborhood Hits	2275	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

RGS12_HUMAN
θ value	1.38821 (rank : 145)	NC score	0.185188 (rank : 135)
Query Neighborhood Hits	201	Target Neighborhood Hits	333	Shared Neighborhood Hits	103
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

STXB4_HUMAN
θ value	1.38821 (rank : 146)	NC score	0.223258 (rank : 119)
Query Neighborhood Hits	201	Target Neighborhood Hits	616	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	1.38821 (rank : 147)	NC score	0.222461 (rank : 120)
Query Neighborhood Hits	201	Target Neighborhood Hits	629	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ZO3_HUMAN
θ value	1.38821 (rank : 148)	NC score	0.306623 (rank : 81)
Query Neighborhood Hits	201	Target Neighborhood Hits	219	Shared Neighborhood Hits	127
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

CNKR2_HUMAN
θ value	1.81305 (rank : 149)	NC score	0.116055 (rank : 168)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	1.81305 (rank : 150)	NC score	0.116133 (rank : 167)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

MY18A_HUMAN
θ value	1.81305 (rank : 151)	NC score	0.045625 (rank : 218)
Query Neighborhood Hits	201	Target Neighborhood Hits	1929	Shared Neighborhood Hits	118
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PZRN3_HUMAN
θ value	1.81305 (rank : 152)	NC score	0.260623 (rank : 107)
Query Neighborhood Hits	201	Target Neighborhood Hits	461	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SHC2_HUMAN
θ value	1.81305 (rank : 153)	NC score	0.067658 (rank : 197)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

TARA_HUMAN
θ value	1.81305 (rank : 154)	NC score	0.025343 (rank : 228)
Query Neighborhood Hits	201	Target Neighborhood Hits	1626	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TMBI1_HUMAN
θ value	1.81305 (rank : 155)	NC score	0.018440 (rank : 245)
Query Neighborhood Hits	201	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q969X1, Q8N1R3, Q8TAM3, Q96K13	Gene names	TMBIM1, RECS1
Domain Architecture
Description	Transmembrane BAX inhibitor motif-containing protein 1 (RECS1 protein homolog).

SH3K1_HUMAN
θ value	2.36792 (rank : 156)	NC score	0.028452 (rank : 223)
Query Neighborhood Hits	201	Target Neighborhood Hits	341	Shared Neighborhood Hits	22
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SNTA1_HUMAN
θ value	2.36792 (rank : 157)	NC score	0.274436 (rank : 94)
Query Neighborhood Hits	201	Target Neighborhood Hits	186	Shared Neighborhood Hits	122
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
θ value	2.36792 (rank : 158)	NC score	0.272218 (rank : 95)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	117
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_HUMAN
θ value	2.36792 (rank : 159)	NC score	0.256482 (rank : 108)
Query Neighborhood Hits	201	Target Neighborhood Hits	157	Shared Neighborhood Hits	109
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	2.36792 (rank : 160)	NC score	0.253864 (rank : 110)
Query Neighborhood Hits	201	Target Neighborhood Hits	160	Shared Neighborhood Hits	107
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

TX1B3_HUMAN
θ value	2.36792 (rank : 161)	NC score	0.336837 (rank : 68)
Query Neighborhood Hits	201	Target Neighborhood Hits	161	Shared Neighborhood Hits	111
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

LOXL1_MOUSE
θ value	3.0926 (rank : 162)	NC score	0.012711 (rank : 251)
Query Neighborhood Hits	201	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

MDC1_HUMAN
θ value	3.0926 (rank : 163)	NC score	0.022406 (rank : 234)
Query Neighborhood Hits	201	Target Neighborhood Hits	1446	Shared Neighborhood Hits	41
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NCOA6_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.021844 (rank : 236)
Query Neighborhood Hits	201	Target Neighborhood Hits	1202	Shared Neighborhood Hits	37
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SMUF1_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.021292 (rank : 237)
Query Neighborhood Hits	201	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

TIAM1_MOUSE
θ value	3.0926 (rank : 166)	NC score	0.051170 (rank : 212)
Query Neighborhood Hits	201	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TX1B3_MOUSE
θ value	3.0926 (rank : 167)	NC score	0.331585 (rank : 69)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

ARH_MOUSE
θ value	4.03905 (rank : 168)	NC score	0.027795 (rank : 224)
Query Neighborhood Hits	201	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

BAT3_MOUSE
θ value	4.03905 (rank : 169)	NC score	0.021887 (rank : 235)
Query Neighborhood Hits	201	Target Neighborhood Hits	518	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

DVL1_HUMAN
θ value	4.03905 (rank : 170)	NC score	0.192961 (rank : 131)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	97
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	4.03905 (rank : 171)	NC score	0.189331 (rank : 132)
Query Neighborhood Hits	201	Target Neighborhood Hits	146	Shared Neighborhood Hits	94
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

FOXN1_MOUSE
θ value	4.03905 (rank : 172)	NC score	0.007900 (rank : 257)
Query Neighborhood Hits	201	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

PLCB1_HUMAN
θ value	4.03905 (rank : 173)	NC score	0.009936 (rank : 255)
Query Neighborhood Hits	201	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

RUSC2_MOUSE
θ value	4.03905 (rank : 174)	NC score	0.018811 (rank : 243)
Query Neighborhood Hits	201	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TXLNB_HUMAN
θ value	4.03905 (rank : 175)	NC score	0.017871 (rank : 246)
Query Neighborhood Hits	201	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

DVL1L_HUMAN
θ value	5.27518 (rank : 176)	NC score	0.193268 (rank : 130)
Query Neighborhood Hits	201	Target Neighborhood Hits	146	Shared Neighborhood Hits	93
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

EPHB4_HUMAN
θ value	5.27518 (rank : 177)	NC score	0.003247 (rank : 263)
Query Neighborhood Hits	201	Target Neighborhood Hits	1056	Shared Neighborhood Hits	18
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

LIMK1_HUMAN
θ value	5.27518 (rank : 178)	NC score	0.025162 (rank : 229)
Query Neighborhood Hits	201	Target Neighborhood Hits	1005	Shared Neighborhood Hits	66
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	5.27518 (rank : 179)	NC score	0.024909 (rank : 230)
Query Neighborhood Hits	201	Target Neighborhood Hits	1008	Shared Neighborhood Hits	66
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RIMB1_HUMAN
θ value	5.27518 (rank : 180)	NC score	0.040201 (rank : 219)
Query Neighborhood Hits	201	Target Neighborhood Hits	1479	Shared Neighborhood Hits	49
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TAU_HUMAN
θ value	5.27518 (rank : 181)	NC score	0.018742 (rank : 244)
Query Neighborhood Hits	201	Target Neighborhood Hits	448	Shared Neighborhood Hits	21
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ZEP1_MOUSE
θ value	5.27518 (rank : 182)	NC score	0.003887 (rank : 262)
Query Neighborhood Hits	201	Target Neighborhood Hits	1063	Shared Neighborhood Hits	21
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

AATK_HUMAN
θ value	6.88961 (rank : 183)	NC score	0.001512 (rank : 265)
Query Neighborhood Hits	201	Target Neighborhood Hits	1243	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CO4A3_HUMAN
θ value	6.88961 (rank : 184)	NC score	0.004861 (rank : 260)
Query Neighborhood Hits	201	Target Neighborhood Hits	421	Shared Neighborhood Hits	19
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

GANAB_HUMAN
θ value	6.88961 (rank : 185)	NC score	0.006259 (rank : 258)
Query Neighborhood Hits	201	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q14697, Q8WTS9, Q9P0X0	Gene names	GANAB, G2AN, KIAA0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha).

IL16_HUMAN
θ value	6.88961 (rank : 186)	NC score	0.310119 (rank : 79)
Query Neighborhood Hits	201	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PZRN4_HUMAN
θ value	6.88961 (rank : 187)	NC score	0.271285 (rank : 96)
Query Neighborhood Hits	201	Target Neighborhood Hits	438	Shared Neighborhood Hits	114
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

SHE_MOUSE
θ value	6.88961 (rank : 188)	NC score	0.016548 (rank : 248)
Query Neighborhood Hits	201	Target Neighborhood Hits	169	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SRRM2_HUMAN
θ value	6.88961 (rank : 189)	NC score	0.037934 (rank : 220)
Query Neighborhood Hits	201	Target Neighborhood Hits	1296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CB027_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.019445 (rank : 242)
Query Neighborhood Hits	201	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

CC025_HUMAN
θ value	8.99809 (rank : 191)	NC score	0.013249 (rank : 250)
Query Neighborhood Hits	201	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXP0, Q69YX4	Gene names	C3orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf25.

CIC_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.020405 (rank : 240)
Query Neighborhood Hits	201	Target Neighborhood Hits	992	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CUED1_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.017601 (rank : 247)
Query Neighborhood Hits	201	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

DEPP_HUMAN
θ value	8.99809 (rank : 194)	NC score	0.013993 (rank : 249)
Query Neighborhood Hits	201	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NTK1, O94997, Q5T735, Q76MX8	Gene names	DEPP, C10orf10, FIG
Domain Architecture	No domain graphic available
Description	Protein DEPP (Decidual protein induced by progesterone) (Fasting- induced gene protein) (FIG).

FOXL1_MOUSE
θ value	8.99809 (rank : 195)	NC score	0.002190 (rank : 264)
Query Neighborhood Hits	201	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

GSPT1_MOUSE
θ value	8.99809 (rank : 196)	NC score	0.004473 (rank : 261)
Query Neighborhood Hits	201	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R050, O88179	Gene names	Gspt1
Domain Architecture
Description	G1 to S phase transition protein 1 homolog.

KLF1_MOUSE
θ value	8.99809 (rank : 197)	NC score	-0.005439 (rank : 267)
Query Neighborhood Hits	201	Target Neighborhood Hits	714	Shared Neighborhood Hits	6
SwissProt Accessions	P46099, O70261	Gene names	Klf1, Elkf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) (Erythroid transcription factor).

LPP_HUMAN
θ value	8.99809 (rank : 198)	NC score	0.011973 (rank : 253)
Query Neighborhood Hits	201	Target Neighborhood Hits	775	Shared Neighborhood Hits	30
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NID2_HUMAN
θ value	8.99809 (rank : 199)	NC score	-0.000890 (rank : 266)
Query Neighborhood Hits	201	Target Neighborhood Hits	456	Shared Neighborhood Hits	8
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

UB7I3_MOUSE
θ value	8.99809 (rank : 200)	NC score	0.005650 (rank : 259)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

ZNHI4_MOUSE
θ value	8.99809 (rank : 201)	NC score	0.010276 (rank : 254)
Query Neighborhood Hits	201	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PT3, Q9CY38	Gene names	Znhit4, Hmga1l4, Papa1
Domain Architecture	No domain graphic available
Description	Zinc finger HIT domain-containing protein 4 (PAP-1-associated protein 1) (PAPA-1) (High mobility group AT-hook 1-like 4).

APXL_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.117960 (rank : 166)
Query Neighborhood Hits	201	Target Neighborhood Hits	553	Shared Neighborhood Hits	71
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

BASP_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.050573 (rank : 215)
Query Neighborhood Hits	201	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CRK_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.050717 (rank : 213)
Query Neighborhood Hits	201	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.050688 (rank : 214)
Query Neighborhood Hits	201	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DVL2_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.164083 (rank : 143)
Query Neighborhood Hits	201	Target Neighborhood Hits	223	Shared Neighborhood Hits	93
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.163596 (rank : 144)
Query Neighborhood Hits	201	Target Neighborhood Hits	233	Shared Neighborhood Hits	93
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.175364 (rank : 140)
Query Neighborhood Hits	201	Target Neighborhood Hits	194	Shared Neighborhood Hits	90
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.175960 (rank : 139)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	93
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

GRASP_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.197202 (rank : 125)
Query Neighborhood Hits	201	Target Neighborhood Hits	147	Shared Neighborhood Hits	86
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.194772 (rank : 128)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

IL16_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.282689 (rank : 89)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	101
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KGUA_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.196889 (rank : 126)
Query Neighborhood Hits	201	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.196703 (rank : 127)
Query Neighborhood Hits	201	Target Neighborhood Hits	45	Shared Neighborhood Hits	27
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LAP2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.093322 (rank : 175)
Query Neighborhood Hits	201	Target Neighborhood Hits	499	Shared Neighborhood Hits	84
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.087688 (rank : 184)
Query Neighborhood Hits	201	Target Neighborhood Hits	482	Shared Neighborhood Hits	82
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LDB3_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.084986 (rank : 188)
Query Neighborhood Hits	201	Target Neighborhood Hits	497	Shared Neighborhood Hits	83
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.077796 (rank : 191)
Query Neighborhood Hits	201	Target Neighborhood Hits	510	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LRRC7_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.101953 (rank : 172)
Query Neighborhood Hits	201	Target Neighborhood Hits	423	Shared Neighborhood Hits	81
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.101660 (rank : 173)
Query Neighborhood Hits	201	Target Neighborhood Hits	416	Shared Neighborhood Hits	81
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PAR6B_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.231428 (rank : 118)
Query Neighborhood Hits	201	Target Neighborhood Hits	126	Shared Neighborhood Hits	97
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.233604 (rank : 116)
Query Neighborhood Hits	201	Target Neighborhood Hits	128	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.232886 (rank : 117)
Query Neighborhood Hits	201	Target Neighborhood Hits	159	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.236579 (rank : 113)
Query Neighborhood Hits	201	Target Neighborhood Hits	121	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDLI1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.088352 (rank : 183)
Query Neighborhood Hits	201	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.092235 (rank : 180)
Query Neighborhood Hits	201	Target Neighborhood Hits	213	Shared Neighborhood Hits	72
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.149178 (rank : 147)
Query Neighborhood Hits	201	Target Neighborhood Hits	245	Shared Neighborhood Hits	87
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.135417 (rank : 155)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDLI3_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.089127 (rank : 182)
Query Neighborhood Hits	201	Target Neighborhood Hits	199	Shared Neighborhood Hits	70
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.079763 (rank : 190)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.086462 (rank : 187)
Query Neighborhood Hits	201	Target Neighborhood Hits	245	Shared Neighborhood Hits	76
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.087342 (rank : 186)
Query Neighborhood Hits	201	Target Neighborhood Hits	233	Shared Neighborhood Hits	77
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.092589 (rank : 178)
Query Neighborhood Hits	201	Target Neighborhood Hits	322	Shared Neighborhood Hits	84
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.092538 (rank : 179)
Query Neighborhood Hits	201	Target Neighborhood Hits	287	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI7_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.076367 (rank : 192)
Query Neighborhood Hits	201	Target Neighborhood Hits	547	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.072374 (rank : 195)
Query Neighborhood Hits	201	Target Neighborhood Hits	279	Shared Neighborhood Hits	71
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZ11_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.303509 (rank : 82)
Query Neighborhood Hits	201	Target Neighborhood Hits	160	Shared Neighborhood Hits	97
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.292852 (rank : 86)
Query Neighborhood Hits	201	Target Neighborhood Hits	154	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD6_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.079980 (rank : 189)
Query Neighborhood Hits	201	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZD8_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.064775 (rank : 200)
Query Neighborhood Hits	201	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PDZK4_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.167232 (rank : 142)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	92
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.169720 (rank : 141)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PSCBP_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.177943 (rank : 138)
Query Neighborhood Hits	201	Target Neighborhood Hits	123	Shared Neighborhood Hits	84
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.184642 (rank : 136)
Query Neighborhood Hits	201	Target Neighborhood Hits	118	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PTN3_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.059091 (rank : 207)
Query Neighborhood Hits	201	Target Neighborhood Hits	258	Shared Neighborhood Hits	75
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.063716 (rank : 201)
Query Neighborhood Hits	201	Target Neighborhood Hits	303	Shared Neighborhood Hits	77
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

RHPN1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.156854 (rank : 146)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.186070 (rank : 134)
Query Neighborhood Hits	201	Target Neighborhood Hits	154	Shared Neighborhood Hits	93
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.126883 (rank : 160)
Query Neighborhood Hits	201	Target Neighborhood Hits	437	Shared Neighborhood Hits	109
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.094647 (rank : 174)
Query Neighborhood Hits	201	Target Neighborhood Hits	342	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.092911 (rank : 176)
Query Neighborhood Hits	201	Target Neighborhood Hits	376	Shared Neighborhood Hits	87
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RPGF2_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.144739 (rank : 150)
Query Neighborhood Hits	201	Target Neighborhood Hits	242	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.161287 (rank : 145)
Query Neighborhood Hits	201	Target Neighborhood Hits	266	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SHC2_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.056495 (rank : 209)
Query Neighborhood Hits	201	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SIPA1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.075079 (rank : 193)
Query Neighborhood Hits	201	Target Neighborhood Hits	250	Shared Neighborhood Hits	28
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SIPA1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.065041 (rank : 199)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SNTG1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.267009 (rank : 99)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.268136 (rank : 98)
Query Neighborhood Hits	201	Target Neighborhood Hits	179	Shared Neighborhood Hits	121
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.296789 (rank : 84)
Query Neighborhood Hits	201	Target Neighborhood Hits	191	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG2_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.263699 (rank : 103)
Query Neighborhood Hits	201	Target Neighborhood Hits	176	Shared Neighborhood Hits	119
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.331232 (rank : 70)
Query Neighborhood Hits	201	Target Neighborhood Hits	162	Shared Neighborhood Hits	108
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SYNP2_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.087524 (rank : 185)
Query Neighborhood Hits	201	Target Neighborhood Hits	323	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYNP2_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.113439 (rank : 170)
Query Neighborhood Hits	201	Target Neighborhood Hits	252	Shared Neighborhood Hits	81
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.145576 (rank : 149)
Query Neighborhood Hits	201	Target Neighborhood Hits	400	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYP2L_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.111949 (rank : 171)
Query Neighborhood Hits	201	Target Neighborhood Hits	289	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

ZO2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.265692 (rank : 101)
Query Neighborhood Hits	201	Target Neighborhood Hits	289	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.265934 (rank : 100)
Query Neighborhood Hits	201	Target Neighborhood Hits	296	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

Hits sorted by NC score

APBA3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	201	Target Neighborhood Hits	201	Shared Neighborhood Hits	201
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
NC score	0.976153 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	201	Target Neighborhood Hits	174	Shared Neighborhood Hits	143
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA2_MOUSE
NC score	0.949553 (rank : 3)	θ value	2.0589e-137 (rank : 4)
Query Neighborhood Hits	201	Target Neighborhood Hits	219	Shared Neighborhood Hits	140
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.948590 (rank : 4)	θ value	2.51683e-135 (rank : 5)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	137
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA1_HUMAN
NC score	0.938851 (rank : 5)	θ value	3.62588e-142 (rank : 3)
Query Neighborhood Hits	201	Target Neighborhood Hits	325	Shared Neighborhood Hits	143
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

SDCB2_MOUSE
NC score	0.525076 (rank : 6)	θ value	1.133e-10 (rank : 7)
Query Neighborhood Hits	201	Target Neighborhood Hits	118	Shared Neighborhood Hits	90
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB2_HUMAN
NC score	0.523936 (rank : 7)	θ value	1.133e-10 (rank : 6)
Query Neighborhood Hits	201	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDCB1_HUMAN
NC score	0.514381 (rank : 8)	θ value	5.26297e-08 (rank : 9)
Query Neighborhood Hits	201	Target Neighborhood Hits	150	Shared Neighborhood Hits	110
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
NC score	0.507145 (rank : 9)	θ value	2.36244e-08 (rank : 8)
Query Neighborhood Hits	201	Target Neighborhood Hits	144	Shared Neighborhood Hits	103
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

GRIP1_MOUSE
NC score	0.465942 (rank : 10)	θ value	8.40245e-06 (rank : 17)
Query Neighborhood Hits	201	Target Neighborhood Hits	241	Shared Neighborhood Hits	142
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_HUMAN
NC score	0.465467 (rank : 11)	θ value	8.40245e-06 (rank : 16)
Query Neighborhood Hits	201	Target Neighborhood Hits	231	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MPDZ_HUMAN
NC score	0.465369 (rank : 12)	θ value	2.21117e-06 (rank : 11)
Query Neighborhood Hits	201	Target Neighborhood Hits	261	Shared Neighborhood Hits	147
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_HUMAN
NC score	0.462940 (rank : 13)	θ value	3.77169e-06 (rank : 13)
Query Neighborhood Hits	201	Target Neighborhood Hits	260	Shared Neighborhood Hits	138
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

GRIP2_HUMAN
NC score	0.459156 (rank : 14)	θ value	9.29e-05 (rank : 27)
Query Neighborhood Hits	201	Target Neighborhood Hits	256	Shared Neighborhood Hits	143
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

MPDZ_MOUSE
NC score	0.453399 (rank : 15)	θ value	0.000158464 (rank : 33)
Query Neighborhood Hits	201	Target Neighborhood Hits	298	Shared Neighborhood Hits	144
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

INADL_MOUSE
NC score	0.453132 (rank : 16)	θ value	9.29e-05 (rank : 28)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	141
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LIN7C_HUMAN
NC score	0.452040 (rank : 17)	θ value	9.29e-05 (rank : 29)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.452040 (rank : 18)	θ value	9.29e-05 (rank : 30)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	131
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_HUMAN
NC score	0.444484 (rank : 19)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	201	Target Neighborhood Hits	200	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.441992 (rank : 20)	θ value	0.00035302 (rank : 40)
Query Neighborhood Hits	201	Target Neighborhood Hits	200	Shared Neighborhood Hits	131
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7A_MOUSE
NC score	0.441547 (rank : 21)	θ value	0.000786445 (rank : 45)
Query Neighborhood Hits	201	Target Neighborhood Hits	193	Shared Neighborhood Hits	133
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.441324 (rank : 22)	θ value	0.000786445 (rank : 44)
Query Neighborhood Hits	201	Target Neighborhood Hits	193	Shared Neighborhood Hits	133
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

MAGI1_MOUSE
NC score	0.436246 (rank : 23)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	201	Target Neighborhood Hits	403	Shared Neighborhood Hits	148
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.432295 (rank : 24)	θ value	1.87187e-05 (rank : 22)
Query Neighborhood Hits	201	Target Neighborhood Hits	388	Shared Neighborhood Hits	148
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

USH1C_HUMAN
NC score	0.432278 (rank : 25)	θ value	0.000461057 (rank : 43)
Query Neighborhood Hits	201	Target Neighborhood Hits	327	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PAR3L_HUMAN
NC score	0.431738 (rank : 26)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	201	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

MAGI2_HUMAN
NC score	0.429199 (rank : 27)	θ value	4.92598e-06 (rank : 15)
Query Neighborhood Hits	201	Target Neighborhood Hits	373	Shared Neighborhood Hits	143
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
NC score	0.428503 (rank : 28)	θ value	2.88788e-06 (rank : 12)
Query Neighborhood Hits	201	Target Neighborhood Hits	370	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PDZD7_HUMAN
NC score	0.427908 (rank : 29)	θ value	0.00509761 (rank : 58)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

DLG3_MOUSE
NC score	0.422677 (rank : 30)	θ value	0.000461057 (rank : 42)
Query Neighborhood Hits	201	Target Neighborhood Hits	274	Shared Neighborhood Hits	131
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
NC score	0.421180 (rank : 31)	θ value	0.000461057 (rank : 41)
Query Neighborhood Hits	201	Target Neighborhood Hits	269	Shared Neighborhood Hits	130
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

USH1C_MOUSE
NC score	0.417102 (rank : 32)	θ value	5.44631e-05 (rank : 26)
Query Neighborhood Hits	201	Target Neighborhood Hits	557	Shared Neighborhood Hits	143
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZD1_MOUSE
NC score	0.415557 (rank : 33)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	201	Target Neighborhood Hits	191	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DLG4_MOUSE
NC score	0.414486 (rank : 34)	θ value	0.21417 (rank : 108)
Query Neighborhood Hits	201	Target Neighborhood Hits	282	Shared Neighborhood Hits	133
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.413959 (rank : 35)	θ value	0.21417 (rank : 107)
Query Neighborhood Hits	201	Target Neighborhood Hits	286	Shared Neighborhood Hits	131
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG2_HUMAN
NC score	0.411960 (rank : 36)	θ value	0.163984 (rank : 99)
Query Neighborhood Hits	201	Target Neighborhood Hits	279	Shared Neighborhood Hits	132
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PARD3_HUMAN
NC score	0.411123 (rank : 37)	θ value	0.00175202 (rank : 49)
Query Neighborhood Hits	201	Target Neighborhood Hits	312	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

DLG2_MOUSE
NC score	0.410553 (rank : 38)	θ value	0.163984 (rank : 100)
Query Neighborhood Hits	201	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PARD3_MOUSE
NC score	0.410489 (rank : 39)	θ value	0.00390308 (rank : 53)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	133
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

DLG1_HUMAN
NC score	0.404935 (rank : 40)	θ value	0.125558 (rank : 95)
Query Neighborhood Hits	201	Target Neighborhood Hits	290	Shared Neighborhood Hits	122
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
NC score	0.403343 (rank : 41)	θ value	0.125558 (rank : 96)
Query Neighborhood Hits	201	Target Neighborhood Hits	285	Shared Neighborhood Hits	123
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

WHRN_HUMAN
NC score	0.399982 (rank : 42)	θ value	0.00509761 (rank : 59)
Query Neighborhood Hits	201	Target Neighborhood Hits	325	Shared Neighborhood Hits	137
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

GOPC_MOUSE
NC score	0.397027 (rank : 43)	θ value	0.00665767 (rank : 62)
Query Neighborhood Hits	201	Target Neighborhood Hits	323	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

WHRN_MOUSE
NC score	0.396106 (rank : 44)	θ value	0.00509761 (rank : 60)
Query Neighborhood Hits	201	Target Neighborhood Hits	412	Shared Neighborhood Hits	138
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

GOPC_HUMAN
NC score	0.391465 (rank : 45)	θ value	0.00665767 (rank : 61)
Query Neighborhood Hits	201	Target Neighborhood Hits	377	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PDZD2_HUMAN
NC score	0.387650 (rank : 46)	θ value	0.00175202 (rank : 50)
Query Neighborhood Hits	201	Target Neighborhood Hits	772	Shared Neighborhood Hits	144
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PDZD3_HUMAN
NC score	0.386226 (rank : 47)	θ value	0.00509761 (rank : 57)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

MPP4_HUMAN
NC score	0.385481 (rank : 48)	θ value	0.00134147 (rank : 47)
Query Neighborhood Hits	201	Target Neighborhood Hits	205	Shared Neighborhood Hits	115
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

LNX1_HUMAN
NC score	0.383028 (rank : 49)	θ value	0.00509761 (rank : 54)
Query Neighborhood Hits	201	Target Neighborhood Hits	379	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
NC score	0.380177 (rank : 50)	θ value	0.00665767 (rank : 63)
Query Neighborhood Hits	201	Target Neighborhood Hits	377	Shared Neighborhood Hits	131
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

PDZD1_HUMAN
NC score	0.374534 (rank : 51)	θ value	0.125558 (rank : 97)
Query Neighborhood Hits	201	Target Neighborhood Hits	190	Shared Neighborhood Hits	119
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

K1849_HUMAN
NC score	0.372764 (rank : 52)	θ value	1.43324e-05 (rank : 19)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	114
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MPP3_MOUSE
NC score	0.371094 (rank : 53)	θ value	0.00665767 (rank : 65)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	118
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.368662 (rank : 54)	θ value	0.00665767 (rank : 64)
Query Neighborhood Hits	201	Target Neighborhood Hits	171	Shared Neighborhood Hits	119
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

LNX2_HUMAN
NC score	0.368540 (rank : 55)	θ value	0.00869519 (rank : 69)
Query Neighborhood Hits	201	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

NHRF2_HUMAN
NC score	0.368132 (rank : 56)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	127
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

LNX2_MOUSE
NC score	0.364585 (rank : 57)	θ value	0.0563607 (rank : 80)
Query Neighborhood Hits	201	Target Neighborhood Hits	407	Shared Neighborhood Hits	128
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PDZD3_MOUSE
NC score	0.363715 (rank : 58)	θ value	0.0431538 (rank : 79)
Query Neighborhood Hits	201	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NHERF_MOUSE
NC score	0.363285 (rank : 59)	θ value	0.279714 (rank : 113)
Query Neighborhood Hits	201	Target Neighborhood Hits	195	Shared Neighborhood Hits	116
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

EM55_HUMAN
NC score	0.362924 (rank : 60)	θ value	4.1701e-05 (rank : 23)
Query Neighborhood Hits	201	Target Neighborhood Hits	228	Shared Neighborhood Hits	115
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
NC score	0.362769 (rank : 61)	θ value	4.1701e-05 (rank : 24)
Query Neighborhood Hits	201	Target Neighborhood Hits	221	Shared Neighborhood Hits	115
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

MPP4_MOUSE
NC score	0.362154 (rank : 62)	θ value	0.00509761 (rank : 55)
Query Neighborhood Hits	201	Target Neighborhood Hits	188	Shared Neighborhood Hits	108
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

NHRF2_MOUSE
NC score	0.357105 (rank : 63)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	201	Target Neighborhood Hits	194	Shared Neighborhood Hits	127
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NHERF_HUMAN
NC score	0.350879 (rank : 64)	θ value	0.279714 (rank : 112)
Query Neighborhood Hits	201	Target Neighborhood Hits	190	Shared Neighborhood Hits	115
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

MPP5_HUMAN
NC score	0.349442 (rank : 65)	θ value	0.163984 (rank : 103)
Query Neighborhood Hits	201	Target Neighborhood Hits	231	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.349289 (rank : 66)	θ value	0.0148317 (rank : 74)
Query Neighborhood Hits	201	Target Neighborhood Hits	226	Shared Neighborhood Hits	112
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

K1849_MOUSE
NC score	0.339265 (rank : 67)	θ value	0.00298849 (rank : 51)
Query Neighborhood Hits	201	Target Neighborhood Hits	335	Shared Neighborhood Hits	118
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

TX1B3_HUMAN
NC score	0.336837 (rank : 68)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	201	Target Neighborhood Hits	161	Shared Neighborhood Hits	111
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.331585 (rank : 69)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

SYJ2B_HUMAN
NC score	0.331232 (rank : 70)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	201	Target Neighborhood Hits	162	Shared Neighborhood Hits	108
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

MPP2_MOUSE
NC score	0.321333 (rank : 71)	θ value	0.000158464 (rank : 34)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_MOUSE
NC score	0.319908 (rank : 72)	θ value	0.00509761 (rank : 56)
Query Neighborhood Hits	201	Target Neighborhood Hits	187	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP6_HUMAN
NC score	0.318905 (rank : 73)	θ value	0.00390308 (rank : 52)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SNTB2_MOUSE
NC score	0.318546 (rank : 74)	θ value	0.0252991 (rank : 76)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	116
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

MPP2_HUMAN
NC score	0.315495 (rank : 75)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	201	Target Neighborhood Hits	173	Shared Neighborhood Hits	85
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PICK1_HUMAN
NC score	0.314198 (rank : 76)	θ value	0.0563607 (rank : 81)
Query Neighborhood Hits	201	Target Neighborhood Hits	132	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

SNTB2_HUMAN
NC score	0.313790 (rank : 77)	θ value	0.0736092 (rank : 86)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	116
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

PICK1_MOUSE
NC score	0.313631 (rank : 78)	θ value	0.0563607 (rank : 82)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	98
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

IL16_HUMAN
NC score	0.310119 (rank : 79)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	201	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

ZO3_MOUSE
NC score	0.308996 (rank : 80)	θ value	1.06291 (rank : 140)
Query Neighborhood Hits	201	Target Neighborhood Hits	224	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_HUMAN
NC score	0.306623 (rank : 81)	θ value	1.38821 (rank : 148)
Query Neighborhood Hits	201	Target Neighborhood Hits	219	Shared Neighborhood Hits	127
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PDZ11_HUMAN
NC score	0.303509 (rank : 82)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	201	Target Neighborhood Hits	160	Shared Neighborhood Hits	97
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

AFAD_HUMAN
NC score	0.303447 (rank : 83)	θ value	0.0148317 (rank : 73)
Query Neighborhood Hits	201	Target Neighborhood Hits	689	Shared Neighborhood Hits	119
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

SNTG2_HUMAN
NC score	0.296789 (rank : 84)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	201	Target Neighborhood Hits	191	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

NEB1_HUMAN
NC score	0.293447 (rank : 85)	θ value	0.00665767 (rank : 66)
Query Neighborhood Hits	201	Target Neighborhood Hits	829	Shared Neighborhood Hits	119
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PDZ11_MOUSE
NC score	0.292852 (rank : 86)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	201	Target Neighborhood Hits	154	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

NEB2_HUMAN
NC score	0.291133 (rank : 87)	θ value	0.00020696 (rank : 35)
Query Neighborhood Hits	201	Target Neighborhood Hits	883	Shared Neighborhood Hits	107
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.287173 (rank : 88)	θ value	0.00020696 (rank : 36)
Query Neighborhood Hits	201	Target Neighborhood Hits	889	Shared Neighborhood Hits	108
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

IL16_MOUSE
NC score	0.282689 (rank : 89)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	101
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LAP4_HUMAN
NC score	0.282188 (rank : 90)	θ value	1.43324e-05 (rank : 20)
Query Neighborhood Hits	201	Target Neighborhood Hits	608	Shared Neighborhood Hits	155
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

ZO1_MOUSE
NC score	0.281986 (rank : 91)	θ value	0.0961366 (rank : 93)
Query Neighborhood Hits	201	Target Neighborhood Hits	453	Shared Neighborhood Hits	129
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_HUMAN
NC score	0.278015 (rank : 92)	θ value	0.0961366 (rank : 92)
Query Neighborhood Hits	201	Target Neighborhood Hits	474	Shared Neighborhood Hits	128
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

LAP4_MOUSE
NC score	0.275747 (rank : 93)	θ value	5.44631e-05 (rank : 25)
Query Neighborhood Hits	201	Target Neighborhood Hits	590	Shared Neighborhood Hits	149
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

SNTA1_HUMAN
NC score	0.274436 (rank : 94)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	201	Target Neighborhood Hits	186	Shared Neighborhood Hits	122
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
NC score	0.272218 (rank : 95)	θ value	2.36792 (rank : 158)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	117
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

PZRN4_HUMAN
NC score	0.271285 (rank : 96)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	201	Target Neighborhood Hits	438	Shared Neighborhood Hits	114
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

DLG5_HUMAN
NC score	0.270389 (rank : 97)	θ value	0.000158464 (rank : 32)
Query Neighborhood Hits	201	Target Neighborhood Hits	1088	Shared Neighborhood Hits	134
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

SNTG1_MOUSE
NC score	0.268136 (rank : 98)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	201	Target Neighborhood Hits	179	Shared Neighborhood Hits	121
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
NC score	0.267009 (rank : 99)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	201	Target Neighborhood Hits	181	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

ZO2_MOUSE
NC score	0.265934 (rank : 100)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	201	Target Neighborhood Hits	296	Shared Neighborhood Hits	134
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_HUMAN
NC score	0.265692 (rank : 101)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	201	Target Neighborhood Hits	289	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PZRN3_MOUSE
NC score	0.265126 (rank : 102)	θ value	0.813845 (rank : 132)
Query Neighborhood Hits	201	Target Neighborhood Hits	447	Shared Neighborhood Hits	117
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTG2_MOUSE
NC score	0.263699 (rank : 103)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	201	Target Neighborhood Hits	176	Shared Neighborhood Hits	119
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

PAR6A_MOUSE
NC score	0.262597 (rank : 104)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	201	Target Neighborhood Hits	115	Shared Neighborhood Hits	97
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

NOS1_HUMAN
NC score	0.261807 (rank : 105)	θ value	1.43324e-05 (rank : 21)
Query Neighborhood Hits	201	Target Neighborhood Hits	218	Shared Neighborhood Hits	106
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PAR6A_HUMAN
NC score	0.261559 (rank : 106)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	201	Target Neighborhood Hits	119	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PZRN3_HUMAN
NC score	0.260623 (rank : 107)	θ value	1.81305 (rank : 152)
Query Neighborhood Hits	201	Target Neighborhood Hits	461	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTB1_HUMAN
NC score	0.256482 (rank : 108)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	201	Target Neighborhood Hits	157	Shared Neighborhood Hits	109
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SHAN2_HUMAN
NC score	0.253895 (rank : 109)	θ value	0.0736092 (rank : 83)
Query Neighborhood Hits	201	Target Neighborhood Hits	346	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SNTB1_MOUSE
NC score	0.253864 (rank : 110)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	201	Target Neighborhood Hits	160	Shared Neighborhood Hits	107
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

PTN13_HUMAN
NC score	0.238995 (rank : 111)	θ value	0.0113563 (rank : 72)
Query Neighborhood Hits	201	Target Neighborhood Hits	471	Shared Neighborhood Hits	144
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

NOS1_MOUSE
NC score	0.236798 (rank : 112)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	201	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PAR6G_MOUSE
NC score	0.236579 (rank : 113)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	201	Target Neighborhood Hits	121	Shared Neighborhood Hits	93
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PTN13_MOUSE
NC score	0.236177 (rank : 114)	θ value	0.00665767 (rank : 67)
Query Neighborhood Hits	201	Target Neighborhood Hits	426	Shared Neighborhood Hits	139
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

SHAN2_MOUSE
NC score	0.234012 (rank : 115)	θ value	0.0736092 (rank : 84)
Query Neighborhood Hits	201	Target Neighborhood Hits	446	Shared Neighborhood Hits	110
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

PAR6B_MOUSE
NC score	0.233604 (rank : 116)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	201	Target Neighborhood Hits	128	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
NC score	0.232886 (rank : 117)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	201	Target Neighborhood Hits	159	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6B_HUMAN
NC score	0.231428 (rank : 118)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	201	Target Neighborhood Hits	126	Shared Neighborhood Hits	97
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

STXB4_HUMAN
NC score	0.223258 (rank : 119)	θ value	1.38821 (rank : 146)
Query Neighborhood Hits	201	Target Neighborhood Hits	616	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
NC score	0.222461 (rank : 120)	θ value	1.38821 (rank : 147)
Query Neighborhood Hits	201	Target Neighborhood Hits	629	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ARHGB_HUMAN
NC score	0.220838 (rank : 121)	θ value	0.125558 (rank : 94)
Query Neighborhood Hits	201	Target Neighborhood Hits	375	Shared Neighborhood Hits	122
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GIPC1_MOUSE
NC score	0.208779 (rank : 122)	θ value	0.62314 (rank : 123)
Query Neighborhood Hits	201	Target Neighborhood Hits	92	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

ARHGC_HUMAN
NC score	0.204319 (rank : 123)	θ value	0.47712 (rank : 115)
Query Neighborhood Hits	201	Target Neighborhood Hits	351	Shared Neighborhood Hits	116
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.201602 (rank : 124)	θ value	0.47712 (rank : 116)
Query Neighborhood Hits	201	Target Neighborhood Hits	344	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GRASP_HUMAN
NC score	0.197202 (rank : 125)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	201	Target Neighborhood Hits	147	Shared Neighborhood Hits	86
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

KGUA_HUMAN
NC score	0.196889 (rank : 126)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	201	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
NC score	0.196703 (rank : 127)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	201	Target Neighborhood Hits	45	Shared Neighborhood Hits	27
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

GRASP_MOUSE
NC score	0.194772 (rank : 128)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GIPC2_HUMAN
NC score	0.194032 (rank : 129)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	201	Target Neighborhood Hits	93	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

DVL1L_HUMAN
NC score	0.193268 (rank : 130)	θ value	5.27518 (rank : 176)
Query Neighborhood Hits	201	Target Neighborhood Hits	146	Shared Neighborhood Hits	93
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
NC score	0.192961 (rank : 131)	θ value	4.03905 (rank : 170)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	97
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.189331 (rank : 132)	θ value	4.03905 (rank : 171)
Query Neighborhood Hits	201	Target Neighborhood Hits	146	Shared Neighborhood Hits	94
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

GIPC1_HUMAN
NC score	0.187037 (rank : 133)	θ value	1.38821 (rank : 142)
Query Neighborhood Hits	201	Target Neighborhood Hits	91	Shared Neighborhood Hits	77
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

RHPN1_MOUSE
NC score	0.186070 (rank : 134)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	201	Target Neighborhood Hits	154	Shared Neighborhood Hits	93
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RGS12_HUMAN
NC score	0.185188 (rank : 135)	θ value	1.38821 (rank : 145)
Query Neighborhood Hits	201	Target Neighborhood Hits	333	Shared Neighborhood Hits	103
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PSCBP_MOUSE
NC score	0.184642 (rank : 136)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	201	Target Neighborhood Hits	118	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SHAN1_HUMAN
NC score	0.183258 (rank : 137)	θ value	0.00134147 (rank : 48)
Query Neighborhood Hits	201	Target Neighborhood Hits	1041	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PSCBP_HUMAN
NC score	0.177943 (rank : 138)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	201	Target Neighborhood Hits	123	Shared Neighborhood Hits	84
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

DVL3_MOUSE
NC score	0.175960 (rank : 139)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	201	Target Neighborhood Hits	198	Shared Neighborhood Hits	93
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.175364 (rank : 140)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	201	Target Neighborhood Hits	194	Shared Neighborhood Hits	90
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PDZK4_MOUSE
NC score	0.169720 (rank : 141)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	93
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.167232 (rank : 142)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	201	Target Neighborhood Hits	165	Shared Neighborhood Hits	92
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

DVL2_HUMAN
NC score	0.164083 (rank : 143)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	201	Target Neighborhood Hits	223	Shared Neighborhood Hits	93
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.163596 (rank : 144)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	201	Target Neighborhood Hits	233	Shared Neighborhood Hits	93
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

RPGF6_HUMAN
NC score	0.161287 (rank : 145)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	201	Target Neighborhood Hits	266	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RHPN1_HUMAN
NC score	0.156854 (rank : 146)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PDLI2_HUMAN
NC score	0.149178 (rank : 147)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	201	Target Neighborhood Hits	245	Shared Neighborhood Hits	87
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

SHC3_HUMAN
NC score	0.147055 (rank : 148)	θ value	0.00665767 (rank : 68)
Query Neighborhood Hits	201	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SYP2L_HUMAN
NC score	0.145576 (rank : 149)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	201	Target Neighborhood Hits	400	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

RPGF2_HUMAN
NC score	0.144739 (rank : 150)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	201	Target Neighborhood Hits	242	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SHC3_MOUSE
NC score	0.144443 (rank : 151)	θ value	0.00869519 (rank : 70)
Query Neighborhood Hits	201	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

GIPC3_HUMAN
NC score	0.139450 (rank : 152)	θ value	0.62314 (rank : 124)
Query Neighborhood Hits	201	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC2_MOUSE
NC score	0.137937 (rank : 153)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	201	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_MOUSE
NC score	0.137035 (rank : 154)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	201	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

PDLI2_MOUSE
NC score	0.135417 (rank : 155)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	201	Target Neighborhood Hits	220	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

CSKP_MOUSE
NC score	0.131616 (rank : 156)	θ value	2.21117e-06 (rank : 10)
Query Neighborhood Hits	201	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.131568 (rank : 157)	θ value	1.43324e-05 (rank : 18)
Query Neighborhood Hits	201	Target Neighborhood Hits	1022	Shared Neighborhood Hits	111
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

SI1L2_HUMAN
NC score	0.127390 (rank : 158)	θ value	0.0961366 (rank : 90)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SHC1_HUMAN
NC score	0.126940 (rank : 159)	θ value	0.0961366 (rank : 88)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	16
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

RIMS1_HUMAN
NC score	0.126883 (rank : 160)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	201	Target Neighborhood Hits	437	Shared Neighborhood Hits	109
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SHC1_MOUSE
NC score	0.125648 (rank : 161)	θ value	0.0961366 (rank : 89)
Query Neighborhood Hits	201	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SI1L3_HUMAN
NC score	0.125528 (rank : 162)	θ value	0.0736092 (rank : 85)
Query Neighborhood Hits	201	Target Neighborhood Hits	305	Shared Neighborhood Hits	44
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SI1L2_MOUSE
NC score	0.125323 (rank : 163)	θ value	0.0961366 (rank : 91)
Query Neighborhood Hits	201	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_MOUSE
NC score	0.120198 (rank : 164)	θ value	0.21417 (rank : 110)
Query Neighborhood Hits	201	Target Neighborhood Hits	189	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SI1L1_HUMAN
NC score	0.120032 (rank : 165)	θ value	0.21417 (rank : 109)
Query Neighborhood Hits	201	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

APXL_HUMAN
NC score	0.117960 (rank : 166)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	201	Target Neighborhood Hits	553	Shared Neighborhood Hits	71
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CNKR2_MOUSE
NC score	0.116133 (rank : 167)	θ value	1.81305 (rank : 150)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.116055 (rank : 168)	θ value	1.81305 (rank : 149)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PCLO_MOUSE
NC score	0.114219 (rank : 169)	θ value	1.38821 (rank : 144)
Query Neighborhood Hits	201	Target Neighborhood Hits	2275	Shared Neighborhood Hits	125
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYNP2_MOUSE
NC score	0.113439 (rank : 170)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	201	Target Neighborhood Hits	252	Shared Neighborhood Hits	81
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_MOUSE
NC score	0.111949 (rank : 171)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	201	Target Neighborhood Hits	289	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

LRRC7_HUMAN
NC score	0.101953 (rank : 172)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	201	Target Neighborhood Hits	423	Shared Neighborhood Hits	81
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.101660 (rank : 173)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	201	Target Neighborhood Hits	416	Shared Neighborhood Hits	81
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RIMS2_HUMAN
NC score	0.094647 (rank : 174)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	201	Target Neighborhood Hits	342	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

LAP2_HUMAN
NC score	0.093322 (rank : 175)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	201	Target Neighborhood Hits	499	Shared Neighborhood Hits	84
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

RIMS2_MOUSE
NC score	0.092911 (rank : 176)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	201	Target Neighborhood Hits	376	Shared Neighborhood Hits	87
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

JIP1_HUMAN
NC score	0.092714 (rank : 177)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	201	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PDLI5_HUMAN
NC score	0.092589 (rank : 178)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	201	Target Neighborhood Hits	322	Shared Neighborhood Hits	84
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
NC score	0.092538 (rank : 179)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	201	Target Neighborhood Hits	287	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI1_MOUSE
NC score	0.092235 (rank : 180)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	201	Target Neighborhood Hits	213	Shared Neighborhood Hits	72
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

JIP1_MOUSE
NC score	0.090172 (rank : 181)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	201	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PDLI3_HUMAN
NC score	0.089127 (rank : 182)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	201	Target Neighborhood Hits	199	Shared Neighborhood Hits	70
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI1_HUMAN
NC score	0.088352 (rank : 183)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	201	Target Neighborhood Hits	242	Shared Neighborhood Hits	68
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

LAP2_MOUSE
NC score	0.087688 (rank : 184)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	201	Target Neighborhood Hits	482	Shared Neighborhood Hits	82
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

SYNP2_HUMAN
NC score	0.087524 (rank : 185)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	201	Target Neighborhood Hits	323	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

PDLI4_MOUSE
NC score	0.087342 (rank : 186)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	201	Target Neighborhood Hits	233	Shared Neighborhood Hits	77
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_HUMAN
NC score	0.086462 (rank : 187)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	201	Target Neighborhood Hits	245	Shared Neighborhood Hits	76
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

LDB3_HUMAN
NC score	0.084986 (rank : 188)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	201	Target Neighborhood Hits	497	Shared Neighborhood Hits	83
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDZD6_HUMAN
NC score	0.079980 (rank : 189)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	201	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDLI3_MOUSE
NC score	0.079763 (rank : 190)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	201	Target Neighborhood Hits	197	Shared Neighborhood Hits	66
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

LDB3_MOUSE
NC score	0.077796 (rank : 191)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	201	Target Neighborhood Hits	510	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

PDLI7_HUMAN
NC score	0.076367 (rank : 192)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	201	Target Neighborhood Hits	547	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

SIPA1_HUMAN
NC score	0.075079 (rank : 193)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	201	Target Neighborhood Hits	250	Shared Neighborhood Hits	28
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

TIAM1_HUMAN
NC score	0.073593 (rank : 194)	θ value	0.813845 (rank : 135)
Query Neighborhood Hits	201	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PDLI7_MOUSE
NC score	0.072374 (rank : 195)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	201	Target Neighborhood Hits	279	Shared Neighborhood Hits	71
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PREX1_HUMAN
NC score	0.069546 (rank : 196)	θ value	0.125558 (rank : 98)
Query Neighborhood Hits	201	Target Neighborhood Hits	177	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SHC2_HUMAN
NC score	0.067658 (rank : 197)	θ value	1.81305 (rank : 153)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

MAST3_HUMAN
NC score	0.067504 (rank : 198)	θ value	0.0113563 (rank : 71)
Query Neighborhood Hits	201	Target Neighborhood Hits	1128	Shared Neighborhood Hits	107
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

SIPA1_MOUSE
NC score	0.065041 (rank : 199)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	201	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

PDZD8_HUMAN
NC score	0.064775 (rank : 200)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	201	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PTN4_HUMAN
NC score	0.063716 (rank : 201)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	201	Target Neighborhood Hits	303	Shared Neighborhood Hits	77
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

MAST1_MOUSE
NC score	0.061425 (rank : 202)	θ value	0.163984 (rank : 102)
Query Neighborhood Hits	201	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
NC score	0.060803 (rank : 203)	θ value	0.0330416 (rank : 77)
Query Neighborhood Hits	201	Target Neighborhood Hits	1189	Shared Neighborhood Hits	101
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST4_HUMAN
NC score	0.060683 (rank : 204)	θ value	0.0193708 (rank : 75)
Query Neighborhood Hits	201	Target Neighborhood Hits	1804	Shared Neighborhood Hits	116
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MAST1_HUMAN
NC score	0.060513 (rank : 205)	θ value	0.163984 (rank : 101)
Query Neighborhood Hits	201	Target Neighborhood Hits	1146	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_MOUSE
NC score	0.059350 (rank : 206)	θ value	0.0330416 (rank : 78)
Query Neighborhood Hits	201	Target Neighborhood Hits	1110	Shared Neighborhood Hits	96
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PTN3_HUMAN
NC score	0.059091 (rank : 207)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	201	Target Neighborhood Hits	258	Shared Neighborhood Hits	75
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

RGS3_MOUSE
NC score	0.058586 (rank : 208)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	201	Target Neighborhood Hits	1621	Shared Neighborhood Hits	89
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SHC2_MOUSE
NC score	0.056495 (rank : 209)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	201	Target Neighborhood Hits	144	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SUCA_HUMAN
NC score	0.055425 (rank : 210)	θ value	0.163984 (rank : 105)
Query Neighborhood Hits	201	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

RGS3_HUMAN
NC score	0.054504 (rank : 211)	θ value	0.163984 (rank : 104)
Query Neighborhood Hits	201	Target Neighborhood Hits	1375	Shared Neighborhood Hits	78
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TIAM1_MOUSE
NC score	0.051170 (rank : 212)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	201	Target Neighborhood Hits	205	Shared Neighborhood Hits	45
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CRK_HUMAN
NC score	0.050717 (rank : 213)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	201	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.050688 (rank : 214)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	201	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

BASP_MOUSE
NC score	0.050573 (rank : 215)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	201	Target Neighborhood Hits	260	Shared Neighborhood Hits	19
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

MY18A_MOUSE
NC score	0.050483 (rank : 216)	θ value	1.06291 (rank : 139)
Query Neighborhood Hits	201	Target Neighborhood Hits	1989	Shared Neighborhood Hits	116
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SUCA_MOUSE
NC score	0.049406 (rank : 217)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	201	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

MY18A_HUMAN
NC score	0.045625 (rank : 218)	θ value	1.81305 (rank : 151)
Query Neighborhood Hits	201	Target Neighborhood Hits	1929	Shared Neighborhood Hits	118
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RIMB1_HUMAN
NC score	0.040201 (rank : 219)	θ value	5.27518 (rank : 180)
Query Neighborhood Hits	201	Target Neighborhood Hits	1479	Shared Neighborhood Hits	49
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRRM2_HUMAN
NC score	0.037934 (rank : 220)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	201	Target Neighborhood Hits	1296	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

BSN_MOUSE
NC score	0.037488 (rank : 221)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	201	Target Neighborhood Hits	2057	Shared Neighborhood Hits	55
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

ARH_HUMAN
NC score	0.035523 (rank : 222)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	201	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

SH3K1_HUMAN
NC score	0.028452 (rank : 223)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	201	Target Neighborhood Hits	341	Shared Neighborhood Hits	22
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ARH_MOUSE
NC score	0.027795 (rank : 224)	θ value	4.03905 (rank : 168)
Query Neighborhood Hits	201	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

PER2_HUMAN
NC score	0.026845 (rank : 225)	θ value	0.0961366 (rank : 87)
Query Neighborhood Hits	201	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

ZIMP7_MOUSE
NC score	0.026721 (rank : 226)	θ value	0.163984 (rank : 106)
Query Neighborhood Hits	201	Target Neighborhood Hits	566	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

MAGE1_HUMAN
NC score	0.025372 (rank : 227)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	201	Target Neighborhood Hits	1389	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

TARA_HUMAN
NC score	0.025343 (rank : 228)	θ value	1.81305 (rank : 154)
Query Neighborhood Hits	201	Target Neighborhood Hits	1626	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

LIMK1_HUMAN
NC score	0.025162 (rank : 229)	θ value	5.27518 (rank : 178)
Query Neighborhood Hits	201	Target Neighborhood Hits	1005	Shared Neighborhood Hits	66
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.024909 (rank : 230)	θ value	5.27518 (rank : 179)
Query Neighborhood Hits	201	Target Neighborhood Hits	1008	Shared Neighborhood Hits	66
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

OGFR_MOUSE
NC score	0.024819 (rank : 231)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	201	Target Neighborhood Hits	584	Shared Neighborhood Hits	22
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

LIMK2_MOUSE
NC score	0.024474 (rank : 232)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	201	Target Neighborhood Hits	998	Shared Neighborhood Hits	56
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_HUMAN
NC score	0.022781 (rank : 233)	θ value	1.38821 (rank : 143)
Query Neighborhood Hits	201	Target Neighborhood Hits	986	Shared Neighborhood Hits	56
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MDC1_HUMAN
NC score	0.022406 (rank : 234)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	201	Target Neighborhood Hits	1446	Shared Neighborhood Hits	41
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

BAT3_MOUSE
NC score	0.021887 (rank : 235)	θ value	4.03905 (rank : 169)
Query Neighborhood Hits	201	Target Neighborhood Hits	518	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

NCOA6_HUMAN
NC score	0.021844 (rank : 236)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	201	Target Neighborhood Hits	1202	Shared Neighborhood Hits	37
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SMUF1_MOUSE
NC score	0.021292 (rank : 237)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	201	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

TBC10_MOUSE
NC score	0.020979 (rank : 238)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	201	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	P58802	Gene names	Tbc1d10a, Epi64, Tbc1d10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

FGD1_MOUSE
NC score	0.020899 (rank : 239)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	201	Target Neighborhood Hits	387	Shared Neighborhood Hits	22
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CIC_HUMAN
NC score	0.020405 (rank : 240)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	201	Target Neighborhood Hits	992	Shared Neighborhood Hits	39
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DGUOK_HUMAN
NC score	0.019723 (rank : 241)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	201	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q16854, P78532, Q16759, Q96BC1	Gene names	DGUOK, DGK
Domain Architecture
Description	Deoxyguanosine kinase, mitochondrial precursor (EC 2.7.1.113) (dGK).

CB027_HUMAN
NC score	0.019445 (rank : 242)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	201	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

RUSC2_MOUSE
NC score	0.018811 (rank : 243)	θ value	4.03905 (rank : 174)
Query Neighborhood Hits	201	Target Neighborhood Hits	305	Shared Neighborhood Hits	18
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TAU_HUMAN
NC score	0.018742 (rank : 244)	θ value	5.27518 (rank : 181)
Query Neighborhood Hits	201	Target Neighborhood Hits	448	Shared Neighborhood Hits	21
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TMBI1_HUMAN
NC score	0.018440 (rank : 245)	θ value	1.81305 (rank : 155)
Query Neighborhood Hits	201	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q969X1, Q8N1R3, Q8TAM3, Q96K13	Gene names	TMBIM1, RECS1
Domain Architecture
Description	Transmembrane BAX inhibitor motif-containing protein 1 (RECS1 protein homolog).

TXLNB_HUMAN
NC score	0.017871 (rank : 246)	θ value	4.03905 (rank : 175)
Query Neighborhood Hits	201	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

CUED1_HUMAN
NC score	0.017601 (rank : 247)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	201	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

SHE_MOUSE
NC score	0.016548 (rank : 248)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	201	Target Neighborhood Hits	169	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

DEPP_HUMAN
NC score	0.013993 (rank : 249)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	201	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NTK1, O94997, Q5T735, Q76MX8	Gene names	DEPP, C10orf10, FIG
Domain Architecture	No domain graphic available
Description	Protein DEPP (Decidual protein induced by progesterone) (Fasting- induced gene protein) (FIG).

CC025_HUMAN
NC score	0.013249 (rank : 250)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	201	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXP0, Q69YX4	Gene names	C3orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf25.

LOXL1_MOUSE
NC score	0.012711 (rank : 251)	θ value	3.0926 (rank : 162)
Query Neighborhood Hits	201	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P97873, Q91ZY4, Q99KX3	Gene names	Loxl1, Lox2, Loxl
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (Lysyl oxidase 2).

ANR25_MOUSE
NC score	0.012471 (rank : 252)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	201	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

LPP_HUMAN
NC score	0.011973 (rank : 253)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	201	Target Neighborhood Hits	775	Shared Neighborhood Hits	30
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

ZNHI4_MOUSE
NC score	0.010276 (rank : 254)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	201	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PT3, Q9CY38	Gene names	Znhit4, Hmga1l4, Papa1
Domain Architecture	No domain graphic available
Description	Zinc finger HIT domain-containing protein 4 (PAP-1-associated protein 1) (PAPA-1) (High mobility group AT-hook 1-like 4).

PLCB1_HUMAN
NC score	0.009936 (rank : 255)	θ value	4.03905 (rank : 173)
Query Neighborhood Hits	201	Target Neighborhood Hits	614	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

ATBF1_MOUSE
NC score	0.009418 (rank : 256)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	201	Target Neighborhood Hits	1841	Shared Neighborhood Hits	34
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

FOXN1_MOUSE
NC score	0.007900 (rank : 257)	θ value	4.03905 (rank : 172)
Query Neighborhood Hits	201	Target Neighborhood Hits	300	Shared Neighborhood Hits	11
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

GANAB_HUMAN
NC score	0.006259 (rank : 258)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	201	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q14697, Q8WTS9, Q9P0X0	Gene names	GANAB, G2AN, KIAA0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha).

UB7I3_MOUSE
NC score	0.005650 (rank : 259)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	201	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

CO4A3_HUMAN
NC score	0.004861 (rank : 260)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	201	Target Neighborhood Hits	421	Shared Neighborhood Hits	19
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

GSPT1_MOUSE
NC score	0.004473 (rank : 261)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	201	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R050, O88179	Gene names	Gspt1
Domain Architecture
Description	G1 to S phase transition protein 1 homolog.

ZEP1_MOUSE
NC score	0.003887 (rank : 262)	θ value	5.27518 (rank : 182)
Query Neighborhood Hits	201	Target Neighborhood Hits	1063	Shared Neighborhood Hits	21
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

EPHB4_HUMAN
NC score	0.003247 (rank : 263)	θ value	5.27518 (rank : 177)
Query Neighborhood Hits	201	Target Neighborhood Hits	1056	Shared Neighborhood Hits	18
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FOXL1_MOUSE
NC score	0.002190 (rank : 264)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	201	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

AATK_HUMAN
NC score	0.001512 (rank : 265)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	201	Target Neighborhood Hits	1243	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

NID2_HUMAN
NC score	-0.000890 (rank : 266)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	201	Target Neighborhood Hits	456	Shared Neighborhood Hits	8
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

KLF1_MOUSE
NC score	-0.005439 (rank : 267)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	201	Target Neighborhood Hits	714	Shared Neighborhood Hits	6
SwissProt Accessions	P46099, O70261	Gene names	Klf1, Elkf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) (Erythroid transcription factor).