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Network neighborhood for query Sequence : PDZD6_HUMAN

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PDZD6_HUMAN
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDZD6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

MPDZ_HUMAN
θ value	0.00298849 (rank : 2)	NC score	0.229129 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	261	Shared Neighborhood Hits	55
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	0.0113563 (rank : 3)	NC score	0.223960 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	298	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PARD3_HUMAN
θ value	0.0252991 (rank : 4)	NC score	0.236282 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	0.0252991 (rank : 5)	NC score	0.236192 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	56
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

STXB4_HUMAN
θ value	0.0330416 (rank : 6)	NC score	0.177461 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	616	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PDZD2_HUMAN
θ value	0.0736092 (rank : 7)	NC score	0.196594 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	772	Shared Neighborhood Hits	55
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DLG2_HUMAN
θ value	0.163984 (rank : 8)	NC score	0.192629 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	56
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	0.163984 (rank : 9)	NC score	0.194429 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

STXB4_MOUSE
θ value	0.163984 (rank : 10)	NC score	0.170640 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	629	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

INADL_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.212708 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

DLG1_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.189454 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	56
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	0.279714 (rank : 13)	NC score	0.190222 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

INADL_MOUSE
θ value	0.279714 (rank : 14)	NC score	0.210538 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	55
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

DLG4_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.191023 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.365318 (rank : 16)	NC score	0.191358 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	282	Shared Neighborhood Hits	56
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

NOS1_MOUSE
θ value	0.365318 (rank : 17)	NC score	0.105496 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ARHGB_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.083189 (rank : 119)
Query Neighborhood Hits	81	Target Neighborhood Hits	375	Shared Neighborhood Hits	44
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GCC2_HUMAN
θ value	0.47712 (rank : 19)	NC score	0.028407 (rank : 157)
Query Neighborhood Hits	81	Target Neighborhood Hits	1558	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

PTN13_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.116805 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	426	Shared Neighborhood Hits	55
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RBP24_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.028443 (rank : 156)
Query Neighborhood Hits	81	Target Neighborhood Hits	1559	Shared Neighborhood Hits	14
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

MAGI2_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.161989 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	373	Shared Neighborhood Hits	55
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	0.62314 (rank : 23)	NC score	0.163550 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	370	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

CR034_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.038271 (rank : 152)
Query Neighborhood Hits	81	Target Neighborhood Hits	538	Shared Neighborhood Hits	6
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

DVL2_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.160735 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	223	Shared Neighborhood Hits	52
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PAR3L_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.213998 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PDZD3_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.140575 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	44
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

TNNI2_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.053250 (rank : 145)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	P48788	Gene names	TNNI2
Domain Architecture
Description	Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform).

DVL2_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.157305 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	233	Shared Neighborhood Hits	51
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL3_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.164102 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	52
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.164530 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PTN13_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.116133 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	471	Shared Neighborhood Hits	55
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TNNI2_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.052211 (rank : 148)
Query Neighborhood Hits	81	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P13412	Gene names	Tnni2
Domain Architecture
Description	Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform).

CE152_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.024216 (rank : 159)
Query Neighborhood Hits	81	Target Neighborhood Hits	976	Shared Neighborhood Hits	9
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

DLG3_HUMAN
θ value	2.36792 (rank : 35)	NC score	0.181945 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	2.36792 (rank : 36)	NC score	0.182823 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	274	Shared Neighborhood Hits	56
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

GOPC_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.138645 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	323	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

KCNH3_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.017252 (rank : 163)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

LAP4_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.113405 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	590	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

NOS1_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.102062 (rank : 100)
Query Neighborhood Hits	81	Target Neighborhood Hits	218	Shared Neighborhood Hits	51
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SACS_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.049628 (rank : 150)
Query Neighborhood Hits	81	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

APXL_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.074671 (rank : 126)
Query Neighborhood Hits	81	Target Neighborhood Hits	553	Shared Neighborhood Hits	37
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

EM55_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.109427 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

LAP4_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.113338 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	608	Shared Neighborhood Hits	56
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LIN7A_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.171456 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.171372 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

SACS_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.048096 (rank : 151)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

OVOL2_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.003415 (rank : 172)
Query Neighborhood Hits	81	Target Neighborhood Hits	709	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CIV7, Q6F661, Q8CIV6, Q8K0D6, Q9D949	Gene names	Ovol2, Ovo2, Zfp339, Znf339
Domain Architecture	No domain graphic available
Description	Transcription factor Ovo-like 2 (mOvo2) (Zinc finger protein 339) (Zinc finger OVO2) (Zinc finger protein mOVO).

PCLO_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.058705 (rank : 137)
Query Neighborhood Hits	81	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

AMFR2_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.019709 (rank : 160)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

CACB4_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.035920 (rank : 153)
Query Neighborhood Hits	81	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CRNL1_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.035186 (rank : 154)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZJ0, Q5JY64, Q8WYI5, Q9BZI9, Q9BZJ1, Q9BZJ2, Q9GZW7, Q9H8F8, Q9NQH5, Q9NYD8	Gene names	CRNKL1, CRN
Domain Architecture
Description	Crooked neck-like protein 1 (Crooked neck homolog) (hCrn).

CRNL1_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.034808 (rank : 155)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P63154, Q542E8, Q9CQC1	Gene names	Crnkl1
Domain Architecture	No domain graphic available
Description	Crooked neck-like protein 1 (Crooked neck homolog).

DLG5_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.109596 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	1088	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DUS16_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.013918 (rank : 168)
Query Neighborhood Hits	81	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

DVL1L_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.152994 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.156310 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	53
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.156189 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

LIN7C_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.168202 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.168202 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

MPP5_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.124557 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.124348 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	226	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SYNG_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.027201 (rank : 158)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

ANFY1_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.005893 (rank : 171)
Query Neighborhood Hits	81	Target Neighborhood Hits	480	Shared Neighborhood Hits	3
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

GALT5_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.007730 (rank : 170)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7M9, Q9UGK7, Q9UHL6	Gene names	GALNT5
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5).

GRIP1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.154683 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

KIF6_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.008975 (rank : 169)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.

LIN7B_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.167232 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MAGI1_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.154710 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	388	Shared Neighborhood Hits	56
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.155901 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	403	Shared Neighborhood Hits	57
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

CK5P2_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.014857 (rank : 167)
Query Neighborhood Hits	81	Target Neighborhood Hits	1433	Shared Neighborhood Hits	16
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

GRIP2_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.160155 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	256	Shared Neighborhood Hits	55
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

JHD2C_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.017259 (rank : 162)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	5
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

JHD2C_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.017212 (rank : 164)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

LEO1_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.015898 (rank : 165)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LEO1_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.015395 (rank : 166)
Query Neighborhood Hits	81	Target Neighborhood Hits	946	Shared Neighborhood Hits	10
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LIN7B_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.165656 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MPP3_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.118566 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	51
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.118983 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

TF3B_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.018151 (rank : 161)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

ZBTB6_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.001006 (rank : 173)
Query Neighborhood Hits	81	Target Neighborhood Hits	805	Shared Neighborhood Hits	4
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).

AFAD_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.119206 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	689	Shared Neighborhood Hits	52
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

APBA1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.094670 (rank : 106)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	55
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.090854 (rank : 112)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	53
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.090969 (rank : 111)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.079980 (rank : 121)
Query Neighborhood Hits	81	Target Neighborhood Hits	201	Shared Neighborhood Hits	49
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.070418 (rank : 129)
Query Neighborhood Hits	81	Target Neighborhood Hits	174	Shared Neighborhood Hits	46
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARHGC_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.058537 (rank : 138)
Query Neighborhood Hits	81	Target Neighborhood Hits	351	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.058073 (rank : 139)
Query Neighborhood Hits	81	Target Neighborhood Hits	344	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EM55_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.100192 (rank : 103)
Query Neighborhood Hits	81	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

GOPC_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.123047 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GRASP_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.060122 (rank : 133)
Query Neighborhood Hits	81	Target Neighborhood Hits	147	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.059264 (rank : 136)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRIP1_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.147630 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

IL16_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.159338 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	50
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.148994 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	48
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

K1849_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.121336 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.118310 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	335	Shared Neighborhood Hits	51
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KGUA_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.083633 (rank : 118)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.084330 (rank : 117)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LNX1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.152807 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	379	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.150861 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	54
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.157346 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.158002 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	407	Shared Neighborhood Hits	55
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LRRC7_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.053819 (rank : 142)
Query Neighborhood Hits	81	Target Neighborhood Hits	423	Shared Neighborhood Hits	47
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.053419 (rank : 144)
Query Neighborhood Hits	81	Target Neighborhood Hits	416	Shared Neighborhood Hits	46
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

MPP2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.091785 (rank : 108)
Query Neighborhood Hits	81	Target Neighborhood Hits	173	Shared Neighborhood Hits	42
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.091044 (rank : 110)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.120540 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.115384 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP6_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.091204 (rank : 109)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.094440 (rank : 107)
Query Neighborhood Hits	81	Target Neighborhood Hits	187	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NEB1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.110750 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	829	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEB2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.102777 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	883	Shared Neighborhood Hits	54
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.101851 (rank : 101)
Query Neighborhood Hits	81	Target Neighborhood Hits	889	Shared Neighborhood Hits	55
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NHERF_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.116300 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.120443 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	195	Shared Neighborhood Hits	41
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.119090 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	197	Shared Neighborhood Hits	45
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.117961 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PAR6A_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.072598 (rank : 128)
Query Neighborhood Hits	81	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.073024 (rank : 127)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6B_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.079750 (rank : 122)
Query Neighborhood Hits	81	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.078091 (rank : 124)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.078595 (rank : 123)
Query Neighborhood Hits	81	Target Neighborhood Hits	159	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.080185 (rank : 120)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDLI2_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.074849 (rank : 125)
Query Neighborhood Hits	81	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDLI2_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.053671 (rank : 143)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDZ11_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.120676 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.121447 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.134150 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.129804 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD3_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.115232 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

PDZD7_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.134883 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDZK4_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.090221 (rank : 113)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.088712 (rank : 114)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PICK1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.086698 (rank : 116)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.088335 (rank : 115)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	48
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PSCBP_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.054022 (rank : 141)
Query Neighborhood Hits	81	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PZRN3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.109351 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	461	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.110764 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	447	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.113861 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RGS12_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.059978 (rank : 134)
Query Neighborhood Hits	81	Target Neighborhood Hits	333	Shared Neighborhood Hits	44
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RHPN1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.056027 (rank : 140)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.066672 (rank : 130)
Query Neighborhood Hits	81	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RIMS1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.050637 (rank : 149)
Query Neighborhood Hits	81	Target Neighborhood Hits	437	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RPGF2_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.053101 (rank : 146)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.063209 (rank : 131)
Query Neighborhood Hits	81	Target Neighborhood Hits	266	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SDCB1_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.059907 (rank : 135)
Query Neighborhood Hits	81	Target Neighborhood Hits	150	Shared Neighborhood Hits	41
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.060572 (rank : 132)
Query Neighborhood Hits	81	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.053052 (rank : 147)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SNTA1_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.104748 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	186	Shared Neighborhood Hits	54
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.101520 (rank : 102)
Query Neighborhood Hits	81	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.103307 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.102962 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	53
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.106253 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.106810 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	47
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.099598 (rank : 104)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.099276 (rank : 105)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.111390 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	191	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.103587 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.178440 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

TX1B3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.108433 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	48
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.107944 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.134035 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	327	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.124733 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	557	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.127050 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	54
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.125216 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

ZO1_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.113183 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	474	Shared Neighborhood Hits	53
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.114303 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.111002 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	289	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.111627 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	296	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO3_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.124326 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.123098 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	224	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

PDZD6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PARD3_HUMAN
NC score	0.236282 (rank : 2)	θ value	0.0252991 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
NC score	0.236192 (rank : 3)	θ value	0.0252991 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	56
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

MPDZ_HUMAN
NC score	0.229129 (rank : 4)	θ value	0.00298849 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	261	Shared Neighborhood Hits	55
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
NC score	0.223960 (rank : 5)	θ value	0.0113563 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	298	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PAR3L_HUMAN
NC score	0.213998 (rank : 6)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

INADL_HUMAN
NC score	0.212708 (rank : 7)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.210538 (rank : 8)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	55
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

PDZD2_HUMAN
NC score	0.196594 (rank : 9)	θ value	0.0736092 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	772	Shared Neighborhood Hits	55
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DLG2_MOUSE
NC score	0.194429 (rank : 10)	θ value	0.163984 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_HUMAN
NC score	0.192629 (rank : 11)	θ value	0.163984 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	56
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_MOUSE
NC score	0.191358 (rank : 12)	θ value	0.365318 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	282	Shared Neighborhood Hits	56
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.191023 (rank : 13)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG1_MOUSE
NC score	0.190222 (rank : 14)	θ value	0.279714 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG1_HUMAN
NC score	0.189454 (rank : 15)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	290	Shared Neighborhood Hits	56
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG3_MOUSE
NC score	0.182823 (rank : 16)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	274	Shared Neighborhood Hits	56
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
NC score	0.181945 (rank : 17)	θ value	2.36792 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

SYJ2B_HUMAN
NC score	0.178440 (rank : 18)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	81	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

STXB4_HUMAN
NC score	0.177461 (rank : 19)	θ value	0.0330416 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	616	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

LIN7A_HUMAN
NC score	0.171456 (rank : 20)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.171372 (rank : 21)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

STXB4_MOUSE
NC score	0.170640 (rank : 22)	θ value	0.163984 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	629	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

LIN7C_HUMAN
NC score	0.168202 (rank : 23)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.168202 (rank : 24)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_MOUSE
NC score	0.167232 (rank : 25)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7B_HUMAN
NC score	0.165656 (rank : 26)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

DVL3_MOUSE
NC score	0.164530 (rank : 27)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	52
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_HUMAN
NC score	0.164102 (rank : 28)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	52
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

MAGI2_MOUSE
NC score	0.163550 (rank : 29)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	370	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.161989 (rank : 30)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	373	Shared Neighborhood Hits	55
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

DVL2_HUMAN
NC score	0.160735 (rank : 31)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	223	Shared Neighborhood Hits	52
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

GRIP2_HUMAN
NC score	0.160155 (rank : 32)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	256	Shared Neighborhood Hits	55
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

IL16_HUMAN
NC score	0.159338 (rank : 33)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	207	Shared Neighborhood Hits	50
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LNX2_MOUSE
NC score	0.158002 (rank : 34)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	81	Target Neighborhood Hits	407	Shared Neighborhood Hits	55
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX2_HUMAN
NC score	0.157346 (rank : 35)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

DVL2_MOUSE
NC score	0.157305 (rank : 36)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	233	Shared Neighborhood Hits	51
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL1_HUMAN
NC score	0.156310 (rank : 37)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	53
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
NC score	0.156189 (rank : 38)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

MAGI1_MOUSE
NC score	0.155901 (rank : 39)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	403	Shared Neighborhood Hits	57
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.154710 (rank : 40)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	388	Shared Neighborhood Hits	56
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GRIP1_HUMAN
NC score	0.154683 (rank : 41)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DVL1L_HUMAN
NC score	0.152994 (rank : 42)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

LNX1_HUMAN
NC score	0.152807 (rank : 43)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	81	Target Neighborhood Hits	379	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
NC score	0.150861 (rank : 44)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	54
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

IL16_MOUSE
NC score	0.148994 (rank : 45)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	48
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

GRIP1_MOUSE
NC score	0.147630 (rank : 46)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	241	Shared Neighborhood Hits	54
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PDZD3_HUMAN
NC score	0.140575 (rank : 47)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	44
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

GOPC_MOUSE
NC score	0.138645 (rank : 48)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	323	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

PDZD7_HUMAN
NC score	0.134883 (rank : 49)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PDZD1_HUMAN
NC score	0.134150 (rank : 50)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

USH1C_HUMAN
NC score	0.134035 (rank : 51)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	81	Target Neighborhood Hits	327	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD1_MOUSE
NC score	0.129804 (rank : 52)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	81	Target Neighborhood Hits	191	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

WHRN_HUMAN
NC score	0.127050 (rank : 53)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	54
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.125216 (rank : 54)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	81	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

USH1C_MOUSE
NC score	0.124733 (rank : 55)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	81	Target Neighborhood Hits	557	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

MPP5_HUMAN
NC score	0.124557 (rank : 56)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.124348 (rank : 57)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	226	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

ZO3_HUMAN
NC score	0.124326 (rank : 58)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
NC score	0.123098 (rank : 59)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	81	Target Neighborhood Hits	224	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GOPC_HUMAN
NC score	0.123047 (rank : 60)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	377	Shared Neighborhood Hits	52
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PDZ11_MOUSE
NC score	0.121447 (rank : 61)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	81	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

K1849_HUMAN
NC score	0.121336 (rank : 62)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PDZ11_HUMAN
NC score	0.120676 (rank : 63)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

MPP4_HUMAN
NC score	0.120540 (rank : 64)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	81	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

NHERF_MOUSE
NC score	0.120443 (rank : 65)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	81	Target Neighborhood Hits	195	Shared Neighborhood Hits	41
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

AFAD_HUMAN
NC score	0.119206 (rank : 66)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	689	Shared Neighborhood Hits	52
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

NHRF2_HUMAN
NC score	0.119090 (rank : 67)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	81	Target Neighborhood Hits	197	Shared Neighborhood Hits	45
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

MPP3_MOUSE
NC score	0.118983 (rank : 68)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.118566 (rank : 69)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	51
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

K1849_MOUSE
NC score	0.118310 (rank : 70)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	335	Shared Neighborhood Hits	51
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NHRF2_MOUSE
NC score	0.117961 (rank : 71)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	81	Target Neighborhood Hits	194	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PTN13_MOUSE
NC score	0.116805 (rank : 72)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	426	Shared Neighborhood Hits	55
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

NHERF_HUMAN
NC score	0.116300 (rank : 73)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	40
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PTN13_HUMAN
NC score	0.116133 (rank : 74)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	471	Shared Neighborhood Hits	55
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

MPP4_MOUSE
NC score	0.115384 (rank : 75)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	81	Target Neighborhood Hits	188	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDZD3_MOUSE
NC score	0.115232 (rank : 76)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

ZO1_MOUSE
NC score	0.114303 (rank : 77)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	81	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PZRN4_HUMAN
NC score	0.113861 (rank : 78)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LAP4_MOUSE
NC score	0.113405 (rank : 79)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	590	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LAP4_HUMAN
NC score	0.113338 (rank : 80)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	608	Shared Neighborhood Hits	56
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

ZO1_HUMAN
NC score	0.113183 (rank : 81)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	81	Target Neighborhood Hits	474	Shared Neighborhood Hits	53
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_MOUSE
NC score	0.111627 (rank : 82)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	81	Target Neighborhood Hits	296	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SNTG2_HUMAN
NC score	0.111390 (rank : 83)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	81	Target Neighborhood Hits	191	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

ZO2_HUMAN
NC score	0.111002 (rank : 84)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	81	Target Neighborhood Hits	289	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PZRN3_MOUSE
NC score	0.110764 (rank : 85)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	81	Target Neighborhood Hits	447	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

NEB1_HUMAN
NC score	0.110750 (rank : 86)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	81	Target Neighborhood Hits	829	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

DLG5_HUMAN
NC score	0.109596 (rank : 87)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	1088	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

EM55_HUMAN
NC score	0.109427 (rank : 88)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

PZRN3_HUMAN
NC score	0.109351 (rank : 89)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	81	Target Neighborhood Hits	461	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

TX1B3_HUMAN
NC score	0.108433 (rank : 90)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	48
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.107944 (rank : 91)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

SNTB2_MOUSE
NC score	0.106810 (rank : 92)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	47
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.106253 (rank : 93)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	47
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

NOS1_MOUSE
NC score	0.105496 (rank : 94)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SNTA1_HUMAN
NC score	0.104748 (rank : 95)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	81	Target Neighborhood Hits	186	Shared Neighborhood Hits	54
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTG2_MOUSE
NC score	0.103587 (rank : 96)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	81	Target Neighborhood Hits	176	Shared Neighborhood Hits	51
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB1_HUMAN
NC score	0.103307 (rank : 97)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	81	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.102962 (rank : 98)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	53
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

NEB2_HUMAN
NC score	0.102777 (rank : 99)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	81	Target Neighborhood Hits	883	Shared Neighborhood Hits	54
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NOS1_HUMAN
NC score	0.102062 (rank : 100)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	218	Shared Neighborhood Hits	51
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NEB2_MOUSE
NC score	0.101851 (rank : 101)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	81	Target Neighborhood Hits	889	Shared Neighborhood Hits	55
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

SNTA1_MOUSE
NC score	0.101520 (rank : 102)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	81	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

EM55_MOUSE
NC score	0.100192 (rank : 103)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SNTG1_HUMAN
NC score	0.099598 (rank : 104)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	81	Target Neighborhood Hits	181	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.099276 (rank : 105)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	81	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

APBA1_HUMAN
NC score	0.094670 (rank : 106)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	55
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

MPP6_MOUSE
NC score	0.094440 (rank : 107)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	81	Target Neighborhood Hits	187	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP2_HUMAN
NC score	0.091785 (rank : 108)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	81	Target Neighborhood Hits	173	Shared Neighborhood Hits	42
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP6_HUMAN
NC score	0.091204 (rank : 109)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	81	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP2_MOUSE
NC score	0.091044 (rank : 110)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	81	Target Neighborhood Hits	189	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

APBA2_MOUSE
NC score	0.090969 (rank : 111)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.090854 (rank : 112)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	53
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

PDZK4_HUMAN
NC score	0.090221 (rank : 113)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
NC score	0.088712 (rank : 114)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	81	Target Neighborhood Hits	165	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PICK1_MOUSE
NC score	0.088335 (rank : 115)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	48
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_HUMAN
NC score	0.086698 (rank : 116)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

KGUA_MOUSE
NC score	0.084330 (rank : 117)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	81	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_HUMAN
NC score	0.083633 (rank : 118)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	18
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

ARHGB_HUMAN
NC score	0.083189 (rank : 119)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	375	Shared Neighborhood Hits	44
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PAR6G_MOUSE
NC score	0.080185 (rank : 120)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

APBA3_HUMAN
NC score	0.079980 (rank : 121)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	201	Shared Neighborhood Hits	49
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PAR6B_HUMAN
NC score	0.079750 (rank : 122)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	81	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
NC score	0.078595 (rank : 123)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	81	Target Neighborhood Hits	159	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6B_MOUSE
NC score	0.078091 (rank : 124)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PDLI2_HUMAN
NC score	0.074849 (rank : 125)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	81	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

APXL_HUMAN
NC score	0.074671 (rank : 126)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	553	Shared Neighborhood Hits	37
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PAR6A_MOUSE
NC score	0.073024 (rank : 127)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PAR6A_HUMAN
NC score	0.072598 (rank : 128)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	81	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

APBA3_MOUSE
NC score	0.070418 (rank : 129)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	174	Shared Neighborhood Hits	46
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

RHPN1_MOUSE
NC score	0.066672 (rank : 130)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	81	Target Neighborhood Hits	154	Shared Neighborhood Hits	40
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RPGF6_HUMAN
NC score	0.063209 (rank : 131)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	81	Target Neighborhood Hits	266	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SDCB1_MOUSE
NC score	0.060572 (rank : 132)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	81	Target Neighborhood Hits	144	Shared Neighborhood Hits	39
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

GRASP_HUMAN
NC score	0.060122 (rank : 133)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	147	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

RGS12_HUMAN
NC score	0.059978 (rank : 134)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	81	Target Neighborhood Hits	333	Shared Neighborhood Hits	44
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SDCB1_HUMAN
NC score	0.059907 (rank : 135)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	81	Target Neighborhood Hits	150	Shared Neighborhood Hits	41
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

GRASP_MOUSE
NC score	0.059264 (rank : 136)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PCLO_MOUSE
NC score	0.058705 (rank : 137)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	2275	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ARHGC_HUMAN
NC score	0.058537 (rank : 138)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	351	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.058073 (rank : 139)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	344	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RHPN1_HUMAN
NC score	0.056027 (rank : 140)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	81	Target Neighborhood Hits	158	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PSCBP_MOUSE
NC score	0.054022 (rank : 141)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	81	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

LRRC7_HUMAN
NC score	0.053819 (rank : 142)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	81	Target Neighborhood Hits	423	Shared Neighborhood Hits	47
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PDLI2_MOUSE
NC score	0.053671 (rank : 143)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	81	Target Neighborhood Hits	220	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

LRRC7_MOUSE
NC score	0.053419 (rank : 144)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	81	Target Neighborhood Hits	416	Shared Neighborhood Hits	46
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

TNNI2_HUMAN
NC score	0.053250 (rank : 145)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	P48788	Gene names	TNNI2
Domain Architecture
Description	Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform).

RPGF2_HUMAN
NC score	0.053101 (rank : 146)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SDCB2_HUMAN
NC score	0.053052 (rank : 147)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TNNI2_MOUSE
NC score	0.052211 (rank : 148)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P13412	Gene names	Tnni2
Domain Architecture
Description	Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform).

RIMS1_HUMAN
NC score	0.050637 (rank : 149)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	81	Target Neighborhood Hits	437	Shared Neighborhood Hits	47
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SACS_MOUSE
NC score	0.049628 (rank : 150)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

SACS_HUMAN
NC score	0.048096 (rank : 151)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

CR034_HUMAN
NC score	0.038271 (rank : 152)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	538	Shared Neighborhood Hits	6
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

CACB4_HUMAN
NC score	0.035920 (rank : 153)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CRNL1_HUMAN
NC score	0.035186 (rank : 154)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZJ0, Q5JY64, Q8WYI5, Q9BZI9, Q9BZJ1, Q9BZJ2, Q9GZW7, Q9H8F8, Q9NQH5, Q9NYD8	Gene names	CRNKL1, CRN
Domain Architecture
Description	Crooked neck-like protein 1 (Crooked neck homolog) (hCrn).

CRNL1_MOUSE
NC score	0.034808 (rank : 155)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P63154, Q542E8, Q9CQC1	Gene names	Crnkl1
Domain Architecture	No domain graphic available
Description	Crooked neck-like protein 1 (Crooked neck homolog).

RBP24_HUMAN
NC score	0.028443 (rank : 156)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	1559	Shared Neighborhood Hits	14
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.028407 (rank : 157)	θ value	0.47712 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	1558	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

SYNG_HUMAN
NC score	0.027201 (rank : 158)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

CE152_HUMAN
NC score	0.024216 (rank : 159)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	976	Shared Neighborhood Hits	9
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

AMFR2_HUMAN
NC score	0.019709 (rank : 160)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

TF3B_MOUSE
NC score	0.018151 (rank : 161)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

JHD2C_HUMAN
NC score	0.017259 (rank : 162)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	279	Shared Neighborhood Hits	5
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

KCNH3_HUMAN
NC score	0.017252 (rank : 163)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

JHD2C_MOUSE
NC score	0.017212 (rank : 164)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	297	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZK6, Q6NV48, Q8BUF5, Q8C4I5, Q8C5Q9	Gene names	Jmjd1c, Jhdm2c, Kiaa1380
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C).

LEO1_HUMAN
NC score	0.015898 (rank : 165)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

LEO1_MOUSE
NC score	0.015395 (rank : 166)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	946	Shared Neighborhood Hits	10
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

CK5P2_HUMAN
NC score	0.014857 (rank : 167)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	1433	Shared Neighborhood Hits	16
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

DUS16_HUMAN
NC score	0.013918 (rank : 168)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

KIF6_HUMAN
NC score	0.008975 (rank : 169)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.

GALT5_HUMAN
NC score	0.007730 (rank : 170)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7M9, Q9UGK7, Q9UHL6	Gene names	GALNT5
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 5 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) (Polypeptide GalNAc transferase 5) (GalNAc-T5) (pp-GaNTase 5).

ANFY1_MOUSE
NC score	0.005893 (rank : 171)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	480	Shared Neighborhood Hits	3
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

OVOL2_MOUSE
NC score	0.003415 (rank : 172)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	709	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CIV7, Q6F661, Q8CIV6, Q8K0D6, Q9D949	Gene names	Ovol2, Ovo2, Zfp339, Znf339
Domain Architecture	No domain graphic available
Description	Transcription factor Ovo-like 2 (mOvo2) (Zinc finger protein 339) (Zinc finger OVO2) (Zinc finger protein mOVO).

ZBTB6_HUMAN
NC score	0.001006 (rank : 173)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	805	Shared Neighborhood Hits	4
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).