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Network neighborhood for query Sequence : NR1H2_HUMAN

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NR1H2_HUMAN
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NR1H2_MOUSE
θ value	1.4585e-175 (rank : 1)	NC score	0.996977 (rank : 2)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR1H2_HUMAN
θ value	8.00302e-174 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	114
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

NR1H3_MOUSE
θ value	3.86495e-152 (rank : 3)	NC score	0.992980 (rank : 3)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_HUMAN
θ value	2.12077e-150 (rank : 4)	NC score	0.992741 (rank : 4)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H4_HUMAN
θ value	9.76566e-63 (rank : 5)	NC score	0.977793 (rank : 5)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H4_MOUSE
θ value	2.17557e-62 (rank : 6)	NC score	0.976773 (rank : 6)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

RARA_HUMAN
θ value	3.60269e-49 (rank : 7)	NC score	0.960459 (rank : 11)
Query Neighborhood Hits	114	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
θ value	5.20228e-48 (rank : 8)	NC score	0.960240 (rank : 12)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARB_HUMAN
θ value	1.15895e-47 (rank : 9)	NC score	0.959777 (rank : 14)
Query Neighborhood Hits	114	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
θ value	1.15895e-47 (rank : 10)	NC score	0.959470 (rank : 15)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

THB2_MOUSE
θ value	3.72821e-46 (rank : 11)	NC score	0.959125 (rank : 17)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB1_HUMAN
θ value	4.86918e-46 (rank : 12)	NC score	0.959095 (rank : 19)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB1_MOUSE
θ value	1.41672e-45 (rank : 13)	NC score	0.958879 (rank : 21)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_HUMAN
θ value	1.41672e-45 (rank : 14)	NC score	0.959278 (rank : 16)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

RARG1_MOUSE
θ value	2.41655e-45 (rank : 15)	NC score	0.958398 (rank : 23)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG2_MOUSE
θ value	2.41655e-45 (rank : 16)	NC score	0.959102 (rank : 18)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

PXR_HUMAN
θ value	1.32601e-43 (rank : 17)	NC score	0.959804 (rank : 13)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

RARG1_HUMAN
θ value	1.73182e-43 (rank : 18)	NC score	0.958491 (rank : 22)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
θ value	1.73182e-43 (rank : 19)	NC score	0.959004 (rank : 20)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

THA_MOUSE
θ value	1.2411e-41 (rank : 20)	NC score	0.957212 (rank : 25)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

PXR_MOUSE
θ value	3.61106e-41 (rank : 21)	NC score	0.961695 (rank : 8)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

THA_HUMAN
θ value	1.3722e-40 (rank : 22)	NC score	0.956844 (rank : 26)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

NR1I3_MOUSE
θ value	5.96599e-36 (rank : 23)	NC score	0.961936 (rank : 7)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

PPARA_MOUSE
θ value	4.27553e-34 (rank : 24)	NC score	0.944642 (rank : 27)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARA_HUMAN
θ value	2.34606e-32 (rank : 25)	NC score	0.942693 (rank : 30)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_HUMAN
θ value	3.06405e-32 (rank : 26)	NC score	0.942765 (rank : 29)
Query Neighborhood Hits	114	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARG_MOUSE
θ value	4.00176e-32 (rank : 27)	NC score	0.942562 (rank : 31)
Query Neighborhood Hits	114	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARD_MOUSE
θ value	5.77852e-31 (rank : 28)	NC score	0.941532 (rank : 32)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

PPARD_HUMAN
θ value	9.8567e-31 (rank : 29)	NC score	0.942867 (rank : 28)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

ERR3_HUMAN
θ value	2.19584e-30 (rank : 30)	NC score	0.924069 (rank : 38)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
θ value	2.19584e-30 (rank : 31)	NC score	0.924069 (rank : 39)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

RXRA_MOUSE
θ value	3.17079e-29 (rank : 32)	NC score	0.917634 (rank : 48)
Query Neighborhood Hits	114	Target Neighborhood Hits	129	Shared Neighborhood Hits	95
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_HUMAN
θ value	5.40856e-29 (rank : 33)	NC score	0.914619 (rank : 50)
Query Neighborhood Hits	114	Target Neighborhood Hits	223	Shared Neighborhood Hits	96
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

VDR_HUMAN
θ value	2.68423e-28 (rank : 34)	NC score	0.957660 (rank : 24)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1D2_HUMAN
θ value	4.57862e-28 (rank : 35)	NC score	0.929878 (rank : 34)
Query Neighborhood Hits	114	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR2E3_MOUSE
θ value	5.97985e-28 (rank : 36)	NC score	0.919280 (rank : 46)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

VDR_MOUSE
θ value	5.97985e-28 (rank : 37)	NC score	0.961417 (rank : 9)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1D2_MOUSE
θ value	1.73987e-27 (rank : 38)	NC score	0.926506 (rank : 35)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

NR1D1_HUMAN
θ value	2.96777e-27 (rank : 39)	NC score	0.933553 (rank : 33)
Query Neighborhood Hits	114	Target Neighborhood Hits	140	Shared Neighborhood Hits	94
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

ESR2_HUMAN
θ value	8.63488e-27 (rank : 40)	NC score	0.909877 (rank : 61)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

HNF4A_HUMAN
θ value	1.47289e-26 (rank : 41)	NC score	0.920555 (rank : 44)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

EAR2_MOUSE
θ value	1.92365e-26 (rank : 42)	NC score	0.908617 (rank : 62)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

ERR2_MOUSE
θ value	1.92365e-26 (rank : 43)	NC score	0.921274 (rank : 42)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

HNF4A_MOUSE
θ value	4.28545e-26 (rank : 44)	NC score	0.920486 (rank : 45)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

COT2_HUMAN
θ value	1.24688e-25 (rank : 45)	NC score	0.908055 (rank : 65)
Query Neighborhood Hits	114	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
θ value	1.24688e-25 (rank : 46)	NC score	0.908055 (rank : 66)
Query Neighborhood Hits	114	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

NR6A1_MOUSE
θ value	2.12685e-25 (rank : 47)	NC score	0.925341 (rank : 37)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	96
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

ERR2_HUMAN
θ value	2.77775e-25 (rank : 48)	NC score	0.920688 (rank : 43)
Query Neighborhood Hits	114	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

NR6A1_HUMAN
θ value	8.08199e-25 (rank : 49)	NC score	0.926351 (rank : 36)
Query Neighborhood Hits	114	Target Neighborhood Hits	108	Shared Neighborhood Hits	96
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR2E3_HUMAN
θ value	1.05554e-24 (rank : 50)	NC score	0.914287 (rank : 52)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

ESR2_MOUSE
θ value	1.37858e-24 (rank : 51)	NC score	0.908476 (rank : 63)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

NR2E1_MOUSE
θ value	2.35151e-24 (rank : 52)	NC score	0.912707 (rank : 59)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

HNF4G_HUMAN
θ value	1.16704e-23 (rank : 53)	NC score	0.916333 (rank : 49)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	95
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR4A1_MOUSE
θ value	5.79196e-23 (rank : 54)	NC score	0.921782 (rank : 41)
Query Neighborhood Hits	114	Target Neighborhood Hits	128	Shared Neighborhood Hits	95
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

NR4A1_HUMAN
θ value	1.29031e-22 (rank : 55)	NC score	0.922107 (rank : 40)
Query Neighborhood Hits	114	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR2E1_HUMAN
θ value	1.6852e-22 (rank : 56)	NC score	0.912971 (rank : 57)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

ESR1_HUMAN
θ value	8.36355e-22 (rank : 57)	NC score	0.906568 (rank : 69)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

COT1_HUMAN
θ value	1.86321e-21 (rank : 58)	NC score	0.905179 (rank : 72)
Query Neighborhood Hits	114	Target Neighborhood Hits	159	Shared Neighborhood Hits	95
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	1.86321e-21 (rank : 59)	NC score	0.905507 (rank : 70)
Query Neighborhood Hits	114	Target Neighborhood Hits	160	Shared Neighborhood Hits	95
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

ESR1_MOUSE
θ value	5.42112e-21 (rank : 60)	NC score	0.907917 (rank : 67)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ANDR_MOUSE
θ value	1.5773e-20 (rank : 61)	NC score	0.862581 (rank : 89)
Query Neighborhood Hits	114	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

MCR_HUMAN
θ value	2.06002e-20 (rank : 62)	NC score	0.867108 (rank : 87)
Query Neighborhood Hits	114	Target Neighborhood Hits	149	Shared Neighborhood Hits	94
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

NR1I3_HUMAN
θ value	2.06002e-20 (rank : 63)	NC score	0.961064 (rank : 10)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

PRGR_MOUSE
θ value	1.92812e-18 (rank : 64)	NC score	0.848125 (rank : 94)
Query Neighborhood Hits	114	Target Neighborhood Hits	286	Shared Neighborhood Hits	99
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

RORA_HUMAN
θ value	1.92812e-18 (rank : 65)	NC score	0.894350 (rank : 77)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
θ value	1.92812e-18 (rank : 66)	NC score	0.894308 (rank : 78)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

TR4_HUMAN
θ value	5.60996e-18 (rank : 67)	NC score	0.889490 (rank : 85)
Query Neighborhood Hits	114	Target Neighborhood Hits	117	Shared Neighborhood Hits	95
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
θ value	5.60996e-18 (rank : 68)	NC score	0.889332 (rank : 86)
Query Neighborhood Hits	114	Target Neighborhood Hits	115	Shared Neighborhood Hits	95
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR2_MOUSE
θ value	7.32683e-18 (rank : 69)	NC score	0.891813 (rank : 84)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	95
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

EAR2_HUMAN
θ value	1.63225e-17 (rank : 70)	NC score	0.908091 (rank : 64)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

NR5A2_MOUSE
θ value	1.63225e-17 (rank : 71)	NC score	0.894399 (rank : 76)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

NR5A2_HUMAN
θ value	2.13179e-17 (rank : 72)	NC score	0.893358 (rank : 80)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

ERR1_HUMAN
θ value	2.7842e-17 (rank : 73)	NC score	0.917791 (rank : 47)
Query Neighborhood Hits	114	Target Neighborhood Hits	157	Shared Neighborhood Hits	96
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

HNF4G_MOUSE
θ value	3.63628e-17 (rank : 74)	NC score	0.914520 (rank : 51)
Query Neighborhood Hits	114	Target Neighborhood Hits	101	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

TR2_HUMAN
θ value	4.74913e-17 (rank : 75)	NC score	0.905194 (rank : 71)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

GCR_HUMAN
θ value	8.10077e-17 (rank : 76)	NC score	0.862168 (rank : 90)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

STF1_HUMAN
θ value	1.058e-16 (rank : 77)	NC score	0.902694 (rank : 73)
Query Neighborhood Hits	114	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
θ value	1.058e-16 (rank : 78)	NC score	0.901462 (rank : 75)
Query Neighborhood Hits	114	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

NR4A2_HUMAN
θ value	1.38178e-16 (rank : 79)	NC score	0.914202 (rank : 53)
Query Neighborhood Hits	114	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
θ value	1.38178e-16 (rank : 80)	NC score	0.914075 (rank : 54)
Query Neighborhood Hits	114	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

PRGR_HUMAN
θ value	1.38178e-16 (rank : 81)	NC score	0.853496 (rank : 93)
Query Neighborhood Hits	114	Target Neighborhood Hits	163	Shared Neighborhood Hits	96
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

RORG_HUMAN
θ value	1.80466e-16 (rank : 82)	NC score	0.892281 (rank : 83)
Query Neighborhood Hits	114	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

RORB_HUMAN
θ value	3.07829e-16 (rank : 83)	NC score	0.892456 (rank : 82)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_MOUSE
θ value	3.07829e-16 (rank : 84)	NC score	0.892612 (rank : 81)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORG_MOUSE
θ value	3.07829e-16 (rank : 85)	NC score	0.893911 (rank : 79)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

RXRB_MOUSE
θ value	4.02038e-16 (rank : 86)	NC score	0.907006 (rank : 68)
Query Neighborhood Hits	114	Target Neighborhood Hits	230	Shared Neighborhood Hits	100
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

GCR_MOUSE
θ value	1.52774e-15 (rank : 87)	NC score	0.855372 (rank : 92)
Query Neighborhood Hits	114	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

RXRB_HUMAN
θ value	1.52774e-15 (rank : 88)	NC score	0.901848 (rank : 74)
Query Neighborhood Hits	114	Target Neighborhood Hits	280	Shared Neighborhood Hits	101
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

ANDR_HUMAN
θ value	7.58209e-15 (rank : 89)	NC score	0.860045 (rank : 91)
Query Neighborhood Hits	114	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

RXRG_MOUSE
θ value	1.29331e-14 (rank : 90)	NC score	0.912847 (rank : 58)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

NR4A3_MOUSE
θ value	2.88119e-14 (rank : 91)	NC score	0.913817 (rank : 55)
Query Neighborhood Hits	114	Target Neighborhood Hits	127	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

RXRG_HUMAN
θ value	3.76295e-14 (rank : 92)	NC score	0.912257 (rank : 60)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

NR4A3_HUMAN
θ value	6.41864e-14 (rank : 93)	NC score	0.913148 (rank : 56)
Query Neighborhood Hits	114	Target Neighborhood Hits	131	Shared Neighborhood Hits	95
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

MCR_MOUSE
θ value	1.09485e-13 (rank : 94)	NC score	0.864084 (rank : 88)
Query Neighborhood Hits	114	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

DAX1_MOUSE
θ value	0.0113563 (rank : 95)	NC score	0.428410 (rank : 95)
Query Neighborhood Hits	114	Target Neighborhood Hits	70	Shared Neighborhood Hits	57
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

GA2L1_HUMAN
θ value	0.47712 (rank : 96)	NC score	0.012087 (rank : 99)
Query Neighborhood Hits	114	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

TLE4_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.006221 (rank : 101)
Query Neighborhood Hits	114	Target Neighborhood Hits	477	Shared Neighborhood Hits	9
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

TLE4_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.006268 (rank : 100)
Query Neighborhood Hits	114	Target Neighborhood Hits	482	Shared Neighborhood Hits	9
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

MAST4_HUMAN
θ value	1.81305 (rank : 99)	NC score	-0.008510 (rank : 117)
Query Neighborhood Hits	114	Target Neighborhood Hits	1804	Shared Neighborhood Hits	9
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

OGFR_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.003268 (rank : 105)
Query Neighborhood Hits	114	Target Neighborhood Hits	1582	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RIMB1_HUMAN
θ value	3.0926 (rank : 101)	NC score	-0.003850 (rank : 113)
Query Neighborhood Hits	114	Target Neighborhood Hits	1479	Shared Neighborhood Hits	10
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

STAR8_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.005360 (rank : 103)
Query Neighborhood Hits	114	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STXB4_MOUSE
θ value	3.0926 (rank : 103)	NC score	-0.001383 (rank : 111)
Query Neighborhood Hits	114	Target Neighborhood Hits	629	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

CNOT4_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.006133 (rank : 102)
Query Neighborhood Hits	114	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

ATS12_MOUSE
θ value	6.88961 (rank : 105)	NC score	0.001143 (rank : 108)
Query Neighborhood Hits	114	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

JADE2_HUMAN
θ value	6.88961 (rank : 106)	NC score	0.000642 (rank : 110)
Query Neighborhood Hits	114	Target Neighborhood Hits	199	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

JIP3_HUMAN
θ value	6.88961 (rank : 107)	NC score	-0.002241 (rank : 112)
Query Neighborhood Hits	114	Target Neighborhood Hits	1039	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

NOTC3_HUMAN
θ value	6.88961 (rank : 108)	NC score	-0.006409 (rank : 114)
Query Neighborhood Hits	114	Target Neighborhood Hits	1062	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

TSC1_HUMAN
θ value	6.88961 (rank : 109)	NC score	0.002883 (rank : 107)
Query Neighborhood Hits	114	Target Neighborhood Hits	765	Shared Neighborhood Hits	9
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

AATK_HUMAN
θ value	8.99809 (rank : 110)	NC score	-0.007644 (rank : 115)
Query Neighborhood Hits	114	Target Neighborhood Hits	1243	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EDD1_HUMAN
θ value	8.99809 (rank : 111)	NC score	0.000737 (rank : 109)
Query Neighborhood Hits	114	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

GP101_MOUSE
θ value	8.99809 (rank : 112)	NC score	-0.008034 (rank : 116)
Query Neighborhood Hits	114	Target Neighborhood Hits	916	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

NAL13_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.003174 (rank : 106)
Query Neighborhood Hits	114	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

ZAR1_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.005089 (rank : 104)
Query Neighborhood Hits	114	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

DAX1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.384026 (rank : 98)
Query Neighborhood Hits	114	Target Neighborhood Hits	65	Shared Neighborhood Hits	56
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

SHP_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.415592 (rank : 96)
Query Neighborhood Hits	114	Target Neighborhood Hits	57	Shared Neighborhood Hits	53
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.401181 (rank : 97)
Query Neighborhood Hits	114	Target Neighborhood Hits	53	Shared Neighborhood Hits	50
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

Hits sorted by NC score

NR1H2_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.00302e-174 (rank : 2)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	114
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

NR1H2_MOUSE
NC score	0.996977 (rank : 2)	θ value	1.4585e-175 (rank : 1)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

NR1H3_MOUSE
NC score	0.992980 (rank : 3)	θ value	3.86495e-152 (rank : 3)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H3_HUMAN
NC score	0.992741 (rank : 4)	θ value	2.12077e-150 (rank : 4)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H4_HUMAN
NC score	0.977793 (rank : 5)	θ value	9.76566e-63 (rank : 5)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	94
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H4_MOUSE
NC score	0.976773 (rank : 6)	θ value	2.17557e-62 (rank : 6)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1I3_MOUSE
NC score	0.961936 (rank : 7)	θ value	5.96599e-36 (rank : 23)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

PXR_MOUSE
NC score	0.961695 (rank : 8)	θ value	3.61106e-41 (rank : 21)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

VDR_MOUSE
NC score	0.961417 (rank : 9)	θ value	5.97985e-28 (rank : 37)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1I3_HUMAN
NC score	0.961064 (rank : 10)	θ value	2.06002e-20 (rank : 63)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

RARA_HUMAN
NC score	0.960459 (rank : 11)	θ value	3.60269e-49 (rank : 7)
Query Neighborhood Hits	114	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
NC score	0.960240 (rank : 12)	θ value	5.20228e-48 (rank : 8)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

PXR_HUMAN
NC score	0.959804 (rank : 13)	θ value	1.32601e-43 (rank : 17)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

RARB_HUMAN
NC score	0.959777 (rank : 14)	θ value	1.15895e-47 (rank : 9)
Query Neighborhood Hits	114	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
NC score	0.959470 (rank : 15)	θ value	1.15895e-47 (rank : 10)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

THB2_HUMAN
NC score	0.959278 (rank : 16)	θ value	1.41672e-45 (rank : 14)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

THB2_MOUSE
NC score	0.959125 (rank : 17)	θ value	3.72821e-46 (rank : 11)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

RARG2_MOUSE
NC score	0.959102 (rank : 18)	θ value	2.41655e-45 (rank : 16)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

THB1_HUMAN
NC score	0.959095 (rank : 19)	θ value	4.86918e-46 (rank : 12)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

RARG2_HUMAN
NC score	0.959004 (rank : 20)	θ value	1.73182e-43 (rank : 19)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

THB1_MOUSE
NC score	0.958879 (rank : 21)	θ value	1.41672e-45 (rank : 13)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

RARG1_HUMAN
NC score	0.958491 (rank : 22)	θ value	1.73182e-43 (rank : 18)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG1_MOUSE
NC score	0.958398 (rank : 23)	θ value	2.41655e-45 (rank : 15)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

VDR_HUMAN
NC score	0.957660 (rank : 24)	θ value	2.68423e-28 (rank : 34)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

THA_MOUSE
NC score	0.957212 (rank : 25)	θ value	1.2411e-41 (rank : 20)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

THA_HUMAN
NC score	0.956844 (rank : 26)	θ value	1.3722e-40 (rank : 22)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

PPARA_MOUSE
NC score	0.944642 (rank : 27)	θ value	4.27553e-34 (rank : 24)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARD_HUMAN
NC score	0.942867 (rank : 28)	θ value	9.8567e-31 (rank : 29)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARG_HUMAN
NC score	0.942765 (rank : 29)	θ value	3.06405e-32 (rank : 26)
Query Neighborhood Hits	114	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARA_HUMAN
NC score	0.942693 (rank : 30)	θ value	2.34606e-32 (rank : 25)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_MOUSE
NC score	0.942562 (rank : 31)	θ value	4.00176e-32 (rank : 27)
Query Neighborhood Hits	114	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARD_MOUSE
NC score	0.941532 (rank : 32)	θ value	5.77852e-31 (rank : 28)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

NR1D1_HUMAN
NC score	0.933553 (rank : 33)	θ value	2.96777e-27 (rank : 39)
Query Neighborhood Hits	114	Target Neighborhood Hits	140	Shared Neighborhood Hits	94
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

NR1D2_HUMAN
NC score	0.929878 (rank : 34)	θ value	4.57862e-28 (rank : 35)
Query Neighborhood Hits	114	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

NR1D2_MOUSE
NC score	0.926506 (rank : 35)	θ value	1.73987e-27 (rank : 38)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

NR6A1_HUMAN
NC score	0.926351 (rank : 36)	θ value	8.08199e-25 (rank : 49)
Query Neighborhood Hits	114	Target Neighborhood Hits	108	Shared Neighborhood Hits	96
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
NC score	0.925341 (rank : 37)	θ value	2.12685e-25 (rank : 47)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	96
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

ERR3_HUMAN
NC score	0.924069 (rank : 38)	θ value	2.19584e-30 (rank : 30)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
NC score	0.924069 (rank : 39)	θ value	2.19584e-30 (rank : 31)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

NR4A1_HUMAN
NC score	0.922107 (rank : 40)	θ value	1.29031e-22 (rank : 55)
Query Neighborhood Hits	114	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A1_MOUSE
NC score	0.921782 (rank : 41)	θ value	5.79196e-23 (rank : 54)
Query Neighborhood Hits	114	Target Neighborhood Hits	128	Shared Neighborhood Hits	95
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

ERR2_MOUSE
NC score	0.921274 (rank : 42)	θ value	1.92365e-26 (rank : 43)
Query Neighborhood Hits	114	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ERR2_HUMAN
NC score	0.920688 (rank : 43)	θ value	2.77775e-25 (rank : 48)
Query Neighborhood Hits	114	Target Neighborhood Hits	108	Shared Neighborhood Hits	95
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

HNF4A_HUMAN
NC score	0.920555 (rank : 44)	θ value	1.47289e-26 (rank : 41)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4A_MOUSE
NC score	0.920486 (rank : 45)	θ value	4.28545e-26 (rank : 44)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

NR2E3_MOUSE
NC score	0.919280 (rank : 46)	θ value	5.97985e-28 (rank : 36)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

ERR1_HUMAN
NC score	0.917791 (rank : 47)	θ value	2.7842e-17 (rank : 73)
Query Neighborhood Hits	114	Target Neighborhood Hits	157	Shared Neighborhood Hits	96
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

RXRA_MOUSE
NC score	0.917634 (rank : 48)	θ value	3.17079e-29 (rank : 32)
Query Neighborhood Hits	114	Target Neighborhood Hits	129	Shared Neighborhood Hits	95
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

HNF4G_HUMAN
NC score	0.916333 (rank : 49)	θ value	1.16704e-23 (rank : 53)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	95
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

RXRA_HUMAN
NC score	0.914619 (rank : 50)	θ value	5.40856e-29 (rank : 33)
Query Neighborhood Hits	114	Target Neighborhood Hits	223	Shared Neighborhood Hits	96
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

HNF4G_MOUSE
NC score	0.914520 (rank : 51)	θ value	3.63628e-17 (rank : 74)
Query Neighborhood Hits	114	Target Neighborhood Hits	101	Shared Neighborhood Hits	95
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

NR2E3_HUMAN
NC score	0.914287 (rank : 52)	θ value	1.05554e-24 (rank : 50)
Query Neighborhood Hits	114	Target Neighborhood Hits	102	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR4A2_HUMAN
NC score	0.914202 (rank : 53)	θ value	1.38178e-16 (rank : 79)
Query Neighborhood Hits	114	Target Neighborhood Hits	120	Shared Neighborhood Hits	94
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
NC score	0.914075 (rank : 54)	θ value	1.38178e-16 (rank : 80)
Query Neighborhood Hits	114	Target Neighborhood Hits	121	Shared Neighborhood Hits	94
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A3_MOUSE
NC score	0.913817 (rank : 55)	θ value	2.88119e-14 (rank : 91)
Query Neighborhood Hits	114	Target Neighborhood Hits	127	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
NC score	0.913148 (rank : 56)	θ value	6.41864e-14 (rank : 93)
Query Neighborhood Hits	114	Target Neighborhood Hits	131	Shared Neighborhood Hits	95
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR2E1_HUMAN
NC score	0.912971 (rank : 57)	θ value	1.6852e-22 (rank : 56)
Query Neighborhood Hits	114	Target Neighborhood Hits	103	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

RXRG_MOUSE
NC score	0.912847 (rank : 58)	θ value	1.29331e-14 (rank : 90)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

NR2E1_MOUSE
NC score	0.912707 (rank : 59)	θ value	2.35151e-24 (rank : 52)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

RXRG_HUMAN
NC score	0.912257 (rank : 60)	θ value	3.76295e-14 (rank : 92)
Query Neighborhood Hits	114	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

ESR2_HUMAN
NC score	0.909877 (rank : 61)	θ value	8.63488e-27 (rank : 40)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

EAR2_MOUSE
NC score	0.908617 (rank : 62)	θ value	1.92365e-26 (rank : 42)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

ESR2_MOUSE
NC score	0.908476 (rank : 63)	θ value	1.37858e-24 (rank : 51)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	94
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

EAR2_HUMAN
NC score	0.908091 (rank : 64)	θ value	1.63225e-17 (rank : 70)
Query Neighborhood Hits	114	Target Neighborhood Hits	106	Shared Neighborhood Hits	95
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

COT2_HUMAN
NC score	0.908055 (rank : 65)	θ value	1.24688e-25 (rank : 45)
Query Neighborhood Hits	114	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
NC score	0.908055 (rank : 66)	θ value	1.24688e-25 (rank : 46)
Query Neighborhood Hits	114	Target Neighborhood Hits	135	Shared Neighborhood Hits	96
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

ESR1_MOUSE
NC score	0.907917 (rank : 67)	θ value	5.42112e-21 (rank : 60)
Query Neighborhood Hits	114	Target Neighborhood Hits	104	Shared Neighborhood Hits	94
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

RXRB_MOUSE
NC score	0.907006 (rank : 68)	θ value	4.02038e-16 (rank : 86)
Query Neighborhood Hits	114	Target Neighborhood Hits	230	Shared Neighborhood Hits	100
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

ESR1_HUMAN
NC score	0.906568 (rank : 69)	θ value	8.36355e-22 (rank : 57)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

COT1_MOUSE
NC score	0.905507 (rank : 70)	θ value	1.86321e-21 (rank : 59)
Query Neighborhood Hits	114	Target Neighborhood Hits	160	Shared Neighborhood Hits	95
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

TR2_HUMAN
NC score	0.905194 (rank : 71)	θ value	4.74913e-17 (rank : 75)
Query Neighborhood Hits	114	Target Neighborhood Hits	110	Shared Neighborhood Hits	95
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

COT1_HUMAN
NC score	0.905179 (rank : 72)	θ value	1.86321e-21 (rank : 58)
Query Neighborhood Hits	114	Target Neighborhood Hits	159	Shared Neighborhood Hits	95
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

STF1_HUMAN
NC score	0.902694 (rank : 73)	θ value	1.058e-16 (rank : 77)
Query Neighborhood Hits	114	Target Neighborhood Hits	132	Shared Neighborhood Hits	95
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

RXRB_HUMAN
NC score	0.901848 (rank : 74)	θ value	1.52774e-15 (rank : 88)
Query Neighborhood Hits	114	Target Neighborhood Hits	280	Shared Neighborhood Hits	101
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

STF1_MOUSE
NC score	0.901462 (rank : 75)	θ value	1.058e-16 (rank : 78)
Query Neighborhood Hits	114	Target Neighborhood Hits	137	Shared Neighborhood Hits	95
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

NR5A2_MOUSE
NC score	0.894399 (rank : 76)	θ value	1.63225e-17 (rank : 71)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

RORA_HUMAN
NC score	0.894350 (rank : 77)	θ value	1.92812e-18 (rank : 65)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
NC score	0.894308 (rank : 78)	θ value	1.92812e-18 (rank : 66)
Query Neighborhood Hits	114	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_MOUSE
NC score	0.893911 (rank : 79)	θ value	3.07829e-16 (rank : 85)
Query Neighborhood Hits	114	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

NR5A2_HUMAN
NC score	0.893358 (rank : 80)	θ value	2.13179e-17 (rank : 72)
Query Neighborhood Hits	114	Target Neighborhood Hits	112	Shared Neighborhood Hits	95
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

RORB_MOUSE
NC score	0.892612 (rank : 81)	θ value	3.07829e-16 (rank : 84)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_HUMAN
NC score	0.892456 (rank : 82)	θ value	3.07829e-16 (rank : 83)
Query Neighborhood Hits	114	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORG_HUMAN
NC score	0.892281 (rank : 83)	θ value	1.80466e-16 (rank : 82)
Query Neighborhood Hits	114	Target Neighborhood Hits	119	Shared Neighborhood Hits	94
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

TR2_MOUSE
NC score	0.891813 (rank : 84)	θ value	7.32683e-18 (rank : 69)
Query Neighborhood Hits	114	Target Neighborhood Hits	100	Shared Neighborhood Hits	95
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

TR4_HUMAN
NC score	0.889490 (rank : 85)	θ value	5.60996e-18 (rank : 67)
Query Neighborhood Hits	114	Target Neighborhood Hits	117	Shared Neighborhood Hits	95
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
NC score	0.889332 (rank : 86)	θ value	5.60996e-18 (rank : 68)
Query Neighborhood Hits	114	Target Neighborhood Hits	115	Shared Neighborhood Hits	95
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

MCR_HUMAN
NC score	0.867108 (rank : 87)	θ value	2.06002e-20 (rank : 62)
Query Neighborhood Hits	114	Target Neighborhood Hits	149	Shared Neighborhood Hits	94
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

MCR_MOUSE
NC score	0.864084 (rank : 88)	θ value	1.09485e-13 (rank : 94)
Query Neighborhood Hits	114	Target Neighborhood Hits	162	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

ANDR_MOUSE
NC score	0.862581 (rank : 89)	θ value	1.5773e-20 (rank : 61)
Query Neighborhood Hits	114	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

GCR_HUMAN
NC score	0.862168 (rank : 90)	θ value	8.10077e-17 (rank : 76)
Query Neighborhood Hits	114	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

ANDR_HUMAN
NC score	0.860045 (rank : 91)	θ value	7.58209e-15 (rank : 89)
Query Neighborhood Hits	114	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

GCR_MOUSE
NC score	0.855372 (rank : 92)	θ value	1.52774e-15 (rank : 87)
Query Neighborhood Hits	114	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

PRGR_HUMAN
NC score	0.853496 (rank : 93)	θ value	1.38178e-16 (rank : 81)
Query Neighborhood Hits	114	Target Neighborhood Hits	163	Shared Neighborhood Hits	96
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

PRGR_MOUSE
NC score	0.848125 (rank : 94)	θ value	1.92812e-18 (rank : 64)
Query Neighborhood Hits	114	Target Neighborhood Hits	286	Shared Neighborhood Hits	99
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

DAX1_MOUSE
NC score	0.428410 (rank : 95)	θ value	0.0113563 (rank : 95)
Query Neighborhood Hits	114	Target Neighborhood Hits	70	Shared Neighborhood Hits	57
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

SHP_HUMAN
NC score	0.415592 (rank : 96)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	114	Target Neighborhood Hits	57	Shared Neighborhood Hits	53
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_MOUSE
NC score	0.401181 (rank : 97)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	114	Target Neighborhood Hits	53	Shared Neighborhood Hits	50
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_HUMAN
NC score	0.384026 (rank : 98)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	114	Target Neighborhood Hits	65	Shared Neighborhood Hits	56
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

GA2L1_HUMAN
NC score	0.012087 (rank : 99)	θ value	0.47712 (rank : 96)
Query Neighborhood Hits	114	Target Neighborhood Hits	177	Shared Neighborhood Hits	5
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

TLE4_MOUSE
NC score	0.006268 (rank : 100)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	114	Target Neighborhood Hits	482	Shared Neighborhood Hits	9
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

TLE4_HUMAN
NC score	0.006221 (rank : 101)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	114	Target Neighborhood Hits	477	Shared Neighborhood Hits	9
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

CNOT4_HUMAN
NC score	0.006133 (rank : 102)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	114	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

STAR8_HUMAN
NC score	0.005360 (rank : 103)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	114	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

ZAR1_HUMAN
NC score	0.005089 (rank : 104)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	114	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

OGFR_HUMAN
NC score	0.003268 (rank : 105)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	114	Target Neighborhood Hits	1582	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

NAL13_HUMAN
NC score	0.003174 (rank : 106)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	114	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

TSC1_HUMAN
NC score	0.002883 (rank : 107)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	114	Target Neighborhood Hits	765	Shared Neighborhood Hits	9
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

ATS12_MOUSE
NC score	0.001143 (rank : 108)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	114	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

EDD1_HUMAN
NC score	0.000737 (rank : 109)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	114	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

JADE2_HUMAN
NC score	0.000642 (rank : 110)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	114	Target Neighborhood Hits	199	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

STXB4_MOUSE
NC score	-0.001383 (rank : 111)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	114	Target Neighborhood Hits	629	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

JIP3_HUMAN
NC score	-0.002241 (rank : 112)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	114	Target Neighborhood Hits	1039	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

RIMB1_HUMAN
NC score	-0.003850 (rank : 113)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	114	Target Neighborhood Hits	1479	Shared Neighborhood Hits	10
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

NOTC3_HUMAN
NC score	-0.006409 (rank : 114)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	114	Target Neighborhood Hits	1062	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

AATK_HUMAN
NC score	-0.007644 (rank : 115)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	114	Target Neighborhood Hits	1243	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

GP101_MOUSE
NC score	-0.008034 (rank : 116)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	114	Target Neighborhood Hits	916	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T62, Q3UUI9	Gene names	Gpr101
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 101.

MAST4_HUMAN
NC score	-0.008510 (rank : 117)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	114	Target Neighborhood Hits	1804	Shared Neighborhood Hits	9
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).