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Network neighborhood for query Sequence : RXRA_MOUSE

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RXRA_MOUSE
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RXRA_HUMAN
θ value	0 (rank : 1)	NC score	0.997263 (rank : 2)
Query Neighborhood Hits	129	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	129	Target Neighborhood Hits	129	Shared Neighborhood Hits	129
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRG_HUMAN
θ value	4.54438e-169 (rank : 3)	NC score	0.996643 (rank : 3)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_MOUSE
θ value	1.32222e-168 (rank : 4)	NC score	0.996639 (rank : 4)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRB_HUMAN
θ value	4.40161e-164 (rank : 5)	NC score	0.987945 (rank : 6)
Query Neighborhood Hits	129	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

RXRB_MOUSE
θ value	3.72618e-163 (rank : 6)	NC score	0.992293 (rank : 5)
Query Neighborhood Hits	129	Target Neighborhood Hits	230	Shared Neighborhood Hits	109
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

COT1_HUMAN
θ value	1.45253e-74 (rank : 7)	NC score	0.978571 (rank : 16)
Query Neighborhood Hits	129	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	1.45253e-74 (rank : 8)	NC score	0.978885 (rank : 15)
Query Neighborhood Hits	129	Target Neighborhood Hits	160	Shared Neighborhood Hits	99
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

COT2_HUMAN
θ value	2.47765e-74 (rank : 9)	NC score	0.980144 (rank : 12)
Query Neighborhood Hits	129	Target Neighborhood Hits	135	Shared Neighborhood Hits	98
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
θ value	2.47765e-74 (rank : 10)	NC score	0.980144 (rank : 13)
Query Neighborhood Hits	129	Target Neighborhood Hits	135	Shared Neighborhood Hits	98
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

HNF4A_HUMAN
θ value	5.91091e-68 (rank : 11)	NC score	0.981182 (rank : 10)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4G_MOUSE
θ value	5.91091e-68 (rank : 12)	NC score	0.981607 (rank : 8)
Query Neighborhood Hits	129	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_HUMAN
θ value	7.71989e-68 (rank : 13)	NC score	0.981935 (rank : 7)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4A_MOUSE
θ value	2.93355e-67 (rank : 14)	NC score	0.981508 (rank : 9)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

EAR2_HUMAN
θ value	1.36269e-64 (rank : 15)	NC score	0.980261 (rank : 11)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

EAR2_MOUSE
θ value	3.35642e-63 (rank : 16)	NC score	0.979377 (rank : 14)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

ERR3_HUMAN
θ value	6.13105e-57 (rank : 17)	NC score	0.964747 (rank : 21)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
θ value	6.13105e-57 (rank : 18)	NC score	0.964747 (rank : 22)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

NR2E3_HUMAN
θ value	2.32979e-56 (rank : 19)	NC score	0.977448 (rank : 17)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

ERR2_MOUSE
θ value	4.85792e-54 (rank : 20)	NC score	0.963789 (rank : 23)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

NR2E3_MOUSE
θ value	1.84601e-53 (rank : 21)	NC score	0.976122 (rank : 18)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

RARB_HUMAN
θ value	1.19655e-52 (rank : 22)	NC score	0.951366 (rank : 26)
Query Neighborhood Hits	129	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
θ value	1.19655e-52 (rank : 23)	NC score	0.951251 (rank : 27)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

ERR2_HUMAN
θ value	4.54686e-52 (rank : 24)	NC score	0.961404 (rank : 24)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

NR2E1_MOUSE
θ value	2.94719e-51 (rank : 25)	NC score	0.974257 (rank : 19)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	99
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

NR2E1_HUMAN
θ value	1.91031e-50 (rank : 26)	NC score	0.972308 (rank : 20)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

RARA_HUMAN
θ value	5.55816e-50 (rank : 27)	NC score	0.950976 (rank : 29)
Query Neighborhood Hits	129	Target Neighborhood Hits	118	Shared Neighborhood Hits	97
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_MOUSE
θ value	5.55816e-50 (rank : 28)	NC score	0.951111 (rank : 28)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARG1_MOUSE
θ value	2.1121e-49 (rank : 29)	NC score	0.949728 (rank : 33)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

RARG2_MOUSE
θ value	2.1121e-49 (rank : 30)	NC score	0.950025 (rank : 32)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARG1_HUMAN
θ value	1.36902e-48 (rank : 31)	NC score	0.950046 (rank : 31)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_HUMAN
θ value	1.36902e-48 (rank : 32)	NC score	0.950200 (rank : 30)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

NR4A2_HUMAN
θ value	2.41655e-45 (rank : 33)	NC score	0.947393 (rank : 35)
Query Neighborhood Hits	129	Target Neighborhood Hits	120	Shared Neighborhood Hits	95
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A2_MOUSE
θ value	2.41655e-45 (rank : 34)	NC score	0.947434 (rank : 34)
Query Neighborhood Hits	129	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

ERR1_HUMAN
θ value	1.73182e-43 (rank : 35)	NC score	0.959022 (rank : 25)
Query Neighborhood Hits	129	Target Neighborhood Hits	157	Shared Neighborhood Hits	99
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

NR4A3_MOUSE
θ value	6.15952e-41 (rank : 36)	NC score	0.946606 (rank : 36)
Query Neighborhood Hits	129	Target Neighborhood Hits	127	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
θ value	8.89434e-40 (rank : 37)	NC score	0.945781 (rank : 37)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

ESR2_MOUSE
θ value	1.51715e-39 (rank : 38)	NC score	0.942157 (rank : 41)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	96
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR2_HUMAN
θ value	3.37985e-39 (rank : 39)	NC score	0.943791 (rank : 39)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

THA_HUMAN
θ value	3.73686e-38 (rank : 40)	NC score	0.930903 (rank : 52)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

THA_MOUSE
θ value	4.88048e-38 (rank : 41)	NC score	0.930876 (rank : 53)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

PPARD_MOUSE
θ value	1.08726e-37 (rank : 42)	NC score	0.924136 (rank : 66)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

PPARD_HUMAN
θ value	4.568e-36 (rank : 43)	NC score	0.925880 (rank : 61)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

PPARA_HUMAN
θ value	1.32909e-35 (rank : 44)	NC score	0.929549 (rank : 56)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

NR4A1_HUMAN
θ value	2.26708e-35 (rank : 45)	NC score	0.944176 (rank : 38)
Query Neighborhood Hits	129	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

NR4A1_MOUSE
θ value	4.27553e-34 (rank : 46)	NC score	0.942554 (rank : 40)
Query Neighborhood Hits	129	Target Neighborhood Hits	128	Shared Neighborhood Hits	94
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

ESR1_HUMAN
θ value	7.29293e-34 (rank : 47)	NC score	0.937500 (rank : 43)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

THB1_HUMAN
θ value	1.6247e-33 (rank : 48)	NC score	0.924665 (rank : 65)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

ESR1_MOUSE
θ value	2.12192e-33 (rank : 49)	NC score	0.937549 (rank : 42)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

NR1H3_HUMAN
θ value	2.12192e-33 (rank : 50)	NC score	0.935842 (rank : 44)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

THB1_MOUSE
θ value	2.12192e-33 (rank : 51)	NC score	0.923757 (rank : 69)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

THB2_MOUSE
θ value	2.12192e-33 (rank : 52)	NC score	0.923783 (rank : 68)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB2_HUMAN
θ value	2.77131e-33 (rank : 53)	NC score	0.925126 (rank : 63)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

PPARA_MOUSE
θ value	4.72714e-33 (rank : 54)	NC score	0.928371 (rank : 59)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

PPARG_HUMAN
θ value	4.72714e-33 (rank : 55)	NC score	0.923592 (rank : 70)
Query Neighborhood Hits	129	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

NR1H3_MOUSE
θ value	8.06329e-33 (rank : 56)	NC score	0.935191 (rank : 46)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

PPARG_MOUSE
θ value	1.0531e-32 (rank : 57)	NC score	0.923161 (rank : 71)
Query Neighborhood Hits	129	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

NR1H4_HUMAN
θ value	8.91499e-32 (rank : 58)	NC score	0.935776 (rank : 45)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H4_MOUSE
θ value	1.52067e-31 (rank : 59)	NC score	0.935141 (rank : 47)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR5A2_HUMAN
θ value	1.98606e-31 (rank : 60)	NC score	0.925359 (rank : 62)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	98
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

TR4_HUMAN
θ value	1.98606e-31 (rank : 61)	NC score	0.929768 (rank : 55)
Query Neighborhood Hits	129	Target Neighborhood Hits	117	Shared Neighborhood Hits	98
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
θ value	7.54701e-31 (rank : 62)	NC score	0.929080 (rank : 57)
Query Neighborhood Hits	129	Target Neighborhood Hits	115	Shared Neighborhood Hits	98
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

NR5A2_MOUSE
θ value	9.8567e-31 (rank : 63)	NC score	0.927228 (rank : 60)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

TR2_MOUSE
θ value	6.38894e-30 (rank : 64)	NC score	0.930006 (rank : 54)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

TR2_HUMAN
θ value	1.08979e-29 (rank : 65)	NC score	0.933450 (rank : 49)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

NR1H2_HUMAN
θ value	3.17079e-29 (rank : 66)	NC score	0.917634 (rank : 74)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

NR1H2_MOUSE
θ value	2.68423e-28 (rank : 67)	NC score	0.923784 (rank : 67)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	97
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

PXR_MOUSE
θ value	2.51237e-26 (rank : 68)	NC score	0.912917 (rank : 75)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

ANDR_MOUSE
θ value	7.30988e-26 (rank : 69)	NC score	0.886162 (rank : 88)
Query Neighborhood Hits	129	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

GCR_HUMAN
θ value	1.62847e-25 (rank : 70)	NC score	0.888049 (rank : 87)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

RORA_HUMAN
θ value	2.12685e-25 (rank : 71)	NC score	0.903330 (rank : 84)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
θ value	2.12685e-25 (rank : 72)	NC score	0.902773 (rank : 85)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

PRGR_MOUSE
θ value	3.62785e-25 (rank : 73)	NC score	0.872562 (rank : 94)
Query Neighborhood Hits	129	Target Neighborhood Hits	286	Shared Neighborhood Hits	97
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

GCR_MOUSE
θ value	6.18819e-25 (rank : 74)	NC score	0.882112 (rank : 90)
Query Neighborhood Hits	129	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

STF1_HUMAN
θ value	8.08199e-25 (rank : 75)	NC score	0.922643 (rank : 72)
Query Neighborhood Hits	129	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

STF1_MOUSE
θ value	8.08199e-25 (rank : 76)	NC score	0.924680 (rank : 64)
Query Neighborhood Hits	129	Target Neighborhood Hits	137	Shared Neighborhood Hits	99
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

RORB_HUMAN
θ value	1.05554e-24 (rank : 77)	NC score	0.903453 (rank : 83)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_MOUSE
θ value	1.05554e-24 (rank : 78)	NC score	0.903456 (rank : 82)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

NR1I3_HUMAN
θ value	1.37858e-24 (rank : 79)	NC score	0.933185 (rank : 50)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

PRGR_HUMAN
θ value	1.80048e-24 (rank : 80)	NC score	0.877533 (rank : 92)
Query Neighborhood Hits	129	Target Neighborhood Hits	163	Shared Neighborhood Hits	98
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

NR1I3_MOUSE
θ value	2.35151e-24 (rank : 81)	NC score	0.928671 (rank : 58)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

NR6A1_HUMAN
θ value	3.07116e-24 (rank : 82)	NC score	0.933677 (rank : 48)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

NR6A1_MOUSE
θ value	3.07116e-24 (rank : 83)	NC score	0.932978 (rank : 51)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

PXR_HUMAN
θ value	3.07116e-24 (rank : 84)	NC score	0.910356 (rank : 77)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

RORG_HUMAN
θ value	4.01107e-24 (rank : 85)	NC score	0.901934 (rank : 86)
Query Neighborhood Hits	129	Target Neighborhood Hits	119	Shared Neighborhood Hits	95
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

RORG_MOUSE
θ value	1.16704e-23 (rank : 86)	NC score	0.905339 (rank : 81)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

MCR_HUMAN
θ value	1.99067e-23 (rank : 87)	NC score	0.880550 (rank : 91)
Query Neighborhood Hits	129	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

NR1D2_HUMAN
θ value	9.87957e-23 (rank : 88)	NC score	0.911295 (rank : 76)
Query Neighborhood Hits	129	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

ANDR_HUMAN
θ value	1.29031e-22 (rank : 89)	NC score	0.883758 (rank : 89)
Query Neighborhood Hits	129	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

NR1D2_MOUSE
θ value	2.20094e-22 (rank : 90)	NC score	0.908662 (rank : 80)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

MCR_MOUSE
θ value	8.36355e-22 (rank : 91)	NC score	0.875998 (rank : 93)
Query Neighborhood Hits	129	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

NR1D1_HUMAN
θ value	1.42661e-21 (rank : 92)	NC score	0.917887 (rank : 73)
Query Neighborhood Hits	129	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

VDR_MOUSE
θ value	1.47631e-18 (rank : 93)	NC score	0.909664 (rank : 78)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	96
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

VDR_HUMAN
θ value	7.32683e-18 (rank : 94)	NC score	0.909520 (rank : 79)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

SHP_HUMAN
θ value	8.67504e-11 (rank : 95)	NC score	0.599346 (rank : 95)
Query Neighborhood Hits	129	Target Neighborhood Hits	57	Shared Neighborhood Hits	56
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_HUMAN
θ value	1.47974e-10 (rank : 96)	NC score	0.557979 (rank : 98)
Query Neighborhood Hits	129	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

SHP_MOUSE
θ value	2.52405e-10 (rank : 97)	NC score	0.588598 (rank : 96)
Query Neighborhood Hits	129	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
θ value	4.30538e-10 (rank : 98)	NC score	0.580676 (rank : 97)
Query Neighborhood Hits	129	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

EP300_HUMAN
θ value	0.0148317 (rank : 99)	NC score	0.029465 (rank : 101)
Query Neighborhood Hits	129	Target Neighborhood Hits	821	Shared Neighborhood Hits	20
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

BCL9_HUMAN
θ value	0.0193708 (rank : 100)	NC score	0.034600 (rank : 100)
Query Neighborhood Hits	129	Target Neighborhood Hits	1008	Shared Neighborhood Hits	19
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCL9_MOUSE
θ value	0.0252991 (rank : 101)	NC score	0.043562 (rank : 99)
Query Neighborhood Hits	129	Target Neighborhood Hits	770	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

MAGE1_HUMAN
θ value	0.21417 (rank : 102)	NC score	0.014132 (rank : 110)
Query Neighborhood Hits	129	Target Neighborhood Hits	1389	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CBP_MOUSE
θ value	0.279714 (rank : 103)	NC score	0.026958 (rank : 102)
Query Neighborhood Hits	129	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_HUMAN
θ value	0.365318 (rank : 104)	NC score	0.025172 (rank : 103)
Query Neighborhood Hits	129	Target Neighborhood Hits	941	Shared Neighborhood Hits	21
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MA2C1_HUMAN
θ value	0.47712 (rank : 105)	NC score	0.024500 (rank : 104)
Query Neighborhood Hits	129	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

NASP_HUMAN
θ value	0.47712 (rank : 106)	NC score	0.008613 (rank : 115)
Query Neighborhood Hits	129	Target Neighborhood Hits	709	Shared Neighborhood Hits	8
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

PER3_HUMAN
θ value	0.62314 (rank : 107)	NC score	0.016025 (rank : 107)
Query Neighborhood Hits	129	Target Neighborhood Hits	479	Shared Neighborhood Hits	18
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

TLE1_MOUSE
θ value	0.62314 (rank : 108)	NC score	0.006817 (rank : 117)
Query Neighborhood Hits	129	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

GLIS1_MOUSE
θ value	0.813845 (rank : 109)	NC score	-0.005259 (rank : 127)
Query Neighborhood Hits	129	Target Neighborhood Hits	751	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).

WFS1_HUMAN
θ value	1.06291 (rank : 110)	NC score	0.018278 (rank : 106)
Query Neighborhood Hits	129	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

WNK4_HUMAN
θ value	1.06291 (rank : 111)	NC score	-0.004328 (rank : 126)
Query Neighborhood Hits	129	Target Neighborhood Hits	1043	Shared Neighborhood Hits	12
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

BRD7_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.014900 (rank : 108)
Query Neighborhood Hits	129	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

BRD7_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.014304 (rank : 109)
Query Neighborhood Hits	129	Target Neighborhood Hits	141	Shared Neighborhood Hits	7
SwissProt Accessions	O88665, Q3UQ56, Q3UU06, Q9CT78	Gene names	Brd7, Bp75
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein).

MA2C1_MOUSE
θ value	1.81305 (rank : 114)	NC score	0.020624 (rank : 105)
Query Neighborhood Hits	129	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

MUC2_HUMAN
θ value	2.36792 (rank : 115)	NC score	0.004142 (rank : 121)
Query Neighborhood Hits	129	Target Neighborhood Hits	906	Shared Neighborhood Hits	16
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

TLE1_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.005186 (rank : 120)
Query Neighborhood Hits	129	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

ARNT_MOUSE
θ value	3.0926 (rank : 117)	NC score	0.002564 (rank : 124)
Query Neighborhood Hits	129	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

KPCD1_HUMAN
θ value	3.0926 (rank : 118)	NC score	-0.007994 (rank : 128)
Query Neighborhood Hits	129	Target Neighborhood Hits	901	Shared Neighborhood Hits	5
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ZCHC8_HUMAN
θ value	3.0926 (rank : 119)	NC score	0.009263 (rank : 113)
Query Neighborhood Hits	129	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZY4, Q7L2P6, Q8N2K5, Q96SK7, Q9NSS2, Q9NSS3	Gene names	ZCCHC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

AP180_HUMAN
θ value	4.03905 (rank : 120)	NC score	0.009423 (rank : 112)
Query Neighborhood Hits	129	Target Neighborhood Hits	183	Shared Neighborhood Hits	15
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

FUBP1_HUMAN
θ value	4.03905 (rank : 121)	NC score	0.006317 (rank : 118)
Query Neighborhood Hits	129	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

FUBP1_MOUSE
θ value	4.03905 (rank : 122)	NC score	0.006283 (rank : 119)
Query Neighborhood Hits	129	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

SON_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.009735 (rank : 111)
Query Neighborhood Hits	129	Target Neighborhood Hits	1568	Shared Neighborhood Hits	26
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

4ET_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.008307 (rank : 116)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

HCFC1_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.002697 (rank : 123)
Query Neighborhood Hits	129	Target Neighborhood Hits	331	Shared Neighborhood Hits	8
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCFC1_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.002730 (rank : 122)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

NEK3_MOUSE
θ value	8.99809 (rank : 127)	NC score	-0.008983 (rank : 129)
Query Neighborhood Hits	129	Target Neighborhood Hits	854	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PRDM2_HUMAN
θ value	8.99809 (rank : 128)	NC score	-0.004157 (rank : 125)
Query Neighborhood Hits	129	Target Neighborhood Hits	1135	Shared Neighborhood Hits	13
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

S23IP_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.008896 (rank : 114)
Query Neighborhood Hits	129	Target Neighborhood Hits	363	Shared Neighborhood Hits	13
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

Hits sorted by NC score

RXRA_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	129	Target Neighborhood Hits	129	Shared Neighborhood Hits	129
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_HUMAN
NC score	0.997263 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	129	Target Neighborhood Hits	223	Shared Neighborhood Hits	122
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRG_HUMAN
NC score	0.996643 (rank : 3)	θ value	4.54438e-169 (rank : 3)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	P48443	Gene names	RXRG, NR2B3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRG_MOUSE
NC score	0.996639 (rank : 4)	θ value	1.32222e-168 (rank : 4)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	P28705	Gene names	Rxrg, Nr2b3
Domain Architecture
Description	Retinoic acid receptor RXR-gamma (Retinoid X receptor gamma).

RXRB_MOUSE
NC score	0.992293 (rank : 5)	θ value	3.72618e-163 (rank : 6)
Query Neighborhood Hits	129	Target Neighborhood Hits	230	Shared Neighborhood Hits	109
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

RXRB_HUMAN
NC score	0.987945 (rank : 6)	θ value	4.40161e-164 (rank : 5)
Query Neighborhood Hits	129	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

HNF4G_HUMAN
NC score	0.981935 (rank : 7)	θ value	7.71989e-68 (rank : 13)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q14541, Q9UH81, Q9UIS6	Gene names	HNF4G, NR2A2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4G_MOUSE
NC score	0.981607 (rank : 8)	θ value	5.91091e-68 (rank : 12)
Query Neighborhood Hits	129	Target Neighborhood Hits	101	Shared Neighborhood Hits	98
SwissProt Accessions	Q9WUU6	Gene names	Hnf4g, Nr2a2
Domain Architecture
Description	Hepatocyte nuclear factor 4-gamma (HNF-4-gamma).

HNF4A_MOUSE
NC score	0.981508 (rank : 9)	θ value	2.93355e-67 (rank : 14)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	P49698	Gene names	Hnf4a, Hnf-4, Hnf4, Nr2a1, Tcf14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

HNF4A_HUMAN
NC score	0.981182 (rank : 10)	θ value	5.91091e-68 (rank : 11)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P41235, O00659, O00723, Q14540, Q92653, Q92654, Q92655, Q99864, Q9NQH0	Gene names	HNF4A, HNF4, NR2A1, TCF14
Domain Architecture
Description	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription factor 14).

EAR2_HUMAN
NC score	0.980261 (rank : 11)	θ value	1.36269e-64 (rank : 15)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10588, Q9BUE8	Gene names	NR2F6, EAR2, ERBAL2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

COT2_HUMAN
NC score	0.980144 (rank : 12)	θ value	2.47765e-74 (rank : 9)
Query Neighborhood Hits	129	Target Neighborhood Hits	135	Shared Neighborhood Hits	98
SwissProt Accessions	P24468, Q03754	Gene names	NR2F2, ARP1, TFCOUP2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

COT2_MOUSE
NC score	0.980144 (rank : 13)	θ value	2.47765e-74 (rank : 10)
Query Neighborhood Hits	129	Target Neighborhood Hits	135	Shared Neighborhood Hits	98
SwissProt Accessions	P43135	Gene names	Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Domain Architecture
Description	COUP transcription factor 2 (COUP-TF2) (COUP-TF II) (Apolipoprotein AI regulatory protein 1) (ARP-1).

EAR2_MOUSE
NC score	0.979377 (rank : 14)	θ value	3.35642e-63 (rank : 16)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P43136, Q61504	Gene names	Nr2f6, Ear-2, Ear2, Erbal2
Domain Architecture
Description	Orphan nuclear receptor EAR-2 (V-erbA-related protein EAR-2).

COT1_MOUSE
NC score	0.978885 (rank : 15)	θ value	1.45253e-74 (rank : 8)
Query Neighborhood Hits	129	Target Neighborhood Hits	160	Shared Neighborhood Hits	99
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

COT1_HUMAN
NC score	0.978571 (rank : 16)	θ value	1.45253e-74 (rank : 7)
Query Neighborhood Hits	129	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

NR2E3_HUMAN
NC score	0.977448 (rank : 17)	θ value	2.32979e-56 (rank : 19)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Y5X4, Q9UHM4	Gene names	NR2E3, PNR, RNR
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR2E3_MOUSE
NC score	0.976122 (rank : 18)	θ value	1.84601e-53 (rank : 21)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	98
SwissProt Accessions	Q9QXZ7	Gene names	Nr2e3, Pnr, Rnr
Domain Architecture
Description	Photoreceptor-specific nuclear receptor (Retina-specific nuclear receptor).

NR2E1_MOUSE
NC score	0.974257 (rank : 19)	θ value	2.94719e-51 (rank : 25)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	99
SwissProt Accessions	Q64104	Gene names	Nr2e1, Tll, Tlx
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (mTll).

NR2E1_HUMAN
NC score	0.972308 (rank : 20)	θ value	1.91031e-50 (rank : 26)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y466	Gene names	NR2E1, TLX
Domain Architecture
Description	Orphan nuclear receptor NR2E1 (Nuclear receptor TLX) (Tailless homolog) (Tll) (hTll).

ERR3_HUMAN
NC score	0.964747 (rank : 21)	θ value	6.13105e-57 (rank : 17)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62508, O75454, O96021, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4	Gene names	ESRRG, ERR3, ERRG2, KIAA0832, NR3B3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (ERR gamma-2).

ERR3_MOUSE
NC score	0.964747 (rank : 22)	θ value	6.13105e-57 (rank : 18)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P62509, O75454, O96021, Q8CHC9, Q9R1F3	Gene names	Esrrg, Err3, Kiaa0832, Nr3b3
Domain Architecture	No domain graphic available
Description	Estrogen-related receptor gamma (Estrogen receptor-related protein 3).

ERR2_MOUSE
NC score	0.963789 (rank : 23)	θ value	4.85792e-54 (rank : 20)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	98
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

ERR2_HUMAN
NC score	0.961404 (rank : 24)	θ value	4.54686e-52 (rank : 24)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	O95718, Q9HCB4	Gene names	ESRRB, ERRB2, NR3B2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2) (ERR beta-2).

ERR1_HUMAN
NC score	0.959022 (rank : 25)	θ value	1.73182e-43 (rank : 35)
Query Neighborhood Hits	129	Target Neighborhood Hits	157	Shared Neighborhood Hits	99
SwissProt Accessions	P11474, Q14514	Gene names	ESRRA, ERR1, ESRL1, NR3B1
Domain Architecture
Description	Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR- alpha) (Estrogen receptor-like 1).

RARB_HUMAN
NC score	0.951366 (rank : 26)	θ value	1.19655e-52 (rank : 22)
Query Neighborhood Hits	129	Target Neighborhood Hits	118	Shared Neighborhood Hits	94
SwissProt Accessions	P10826, P12891, Q00989, Q15298, Q9UN48	Gene names	RARB, HAP, NR1B2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta) (RAR-epsilon) (HBV-activated protein).

RARB_MOUSE
NC score	0.951251 (rank : 27)	θ value	1.19655e-52 (rank : 23)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	P22605, P11417, P22604	Gene names	Rarb, Nr1b2
Domain Architecture
Description	Retinoic acid receptor beta (RAR-beta).

RARA_MOUSE
NC score	0.951111 (rank : 28)	θ value	5.55816e-50 (rank : 28)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P11416, P22603	Gene names	Rara, Nr1b1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARA_HUMAN
NC score	0.950976 (rank : 29)	θ value	5.55816e-50 (rank : 27)
Query Neighborhood Hits	129	Target Neighborhood Hits	118	Shared Neighborhood Hits	97
SwissProt Accessions	P10276, P78456, Q13440, Q13441, Q9NQS0	Gene names	RARA, NR1B1
Domain Architecture
Description	Retinoic acid receptor alpha (RAR-alpha).

RARG2_HUMAN
NC score	0.950200 (rank : 30)	θ value	1.36902e-48 (rank : 32)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	95
SwissProt Accessions	P22932, Q15281	Gene names	RARG, NR1B3
Domain Architecture	No domain graphic available
Description	Retinoic acid receptor gamma-2 (RAR-gamma-2).

RARG1_HUMAN
NC score	0.950046 (rank : 31)	θ value	1.36902e-48 (rank : 31)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	95
SwissProt Accessions	P13631	Gene names	RARG, NR1B3
Domain Architecture
Description	Retinoic acid receptor gamma-1 (RAR-gamma-1).

RARG2_MOUSE
NC score	0.950025 (rank : 32)	θ value	2.1121e-49 (rank : 30)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P20787	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-B (RAR-gamma-B).

RARG1_MOUSE
NC score	0.949728 (rank : 33)	θ value	2.1121e-49 (rank : 29)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	95
SwissProt Accessions	P18911, Q91VK5	Gene names	Rarg, Nr1b3
Domain Architecture
Description	Retinoic acid receptor gamma-A (RAR-gamma-A).

NR4A2_MOUSE
NC score	0.947434 (rank : 34)	θ value	2.41655e-45 (rank : 34)
Query Neighborhood Hits	129	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q06219, O08690	Gene names	Nr4a2, Nurr1
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (NUR- related factor 1).

NR4A2_HUMAN
NC score	0.947393 (rank : 35)	θ value	2.41655e-45 (rank : 33)
Query Neighborhood Hits	129	Target Neighborhood Hits	120	Shared Neighborhood Hits	95
SwissProt Accessions	P43354, Q16311	Gene names	NR4A2, NOT, NURR1, TINUR
Domain Architecture
Description	Orphan nuclear receptor NR4A2 (Orphan nuclear receptor NURR1) (Immediate-early response protein NOT) (Transcriptionally-inducible nuclear receptor).

NR4A3_MOUSE
NC score	0.946606 (rank : 36)	θ value	6.15952e-41 (rank : 36)
Query Neighborhood Hits	129	Target Neighborhood Hits	127	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZB6, Q9QZB5	Gene names	Nr4a3, Tec
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Orphan nuclear receptor TEC) (Translocated in extraskeletal chondrosarcoma).

NR4A3_HUMAN
NC score	0.945781 (rank : 37)	θ value	8.89434e-40 (rank : 37)
Query Neighborhood Hits	129	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q92570, Q12935, Q14979, Q16420, Q4VXA9, Q9UEK2, Q9UEK3	Gene names	NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Domain Architecture
Description	Orphan nuclear receptor NR4A3 (Nuclear hormone receptor NOR-1) (Neuron-derived orphan receptor 1) (Mitogen-induced nuclear orphan receptor).

NR4A1_HUMAN
NC score	0.944176 (rank : 38)	θ value	2.26708e-35 (rank : 45)
Query Neighborhood Hits	129	Target Neighborhood Hits	133	Shared Neighborhood Hits	96
SwissProt Accessions	P22736	Gene names	NR4A1, GFRP1, HMR, NAK1
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Early response protein NAK1) (TR3 orphan receptor) (ST-59).

ESR2_HUMAN
NC score	0.943791 (rank : 39)	θ value	3.37985e-39 (rank : 39)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	Q92731, O60608, O60685, O60702, O60703, O75583, O75584, Q86Z31, Q9UEV6, Q9UHD3, Q9UQK9	Gene names	ESR2, ESTRB, NR3A2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

NR4A1_MOUSE
NC score	0.942554 (rank : 40)	θ value	4.27553e-34 (rank : 46)
Query Neighborhood Hits	129	Target Neighborhood Hits	128	Shared Neighborhood Hits	94
SwissProt Accessions	P12813	Gene names	Nr4a1, Gfrp, Hmr, N10, Nur77
Domain Architecture
Description	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR) (Nuclear hormone receptor NUR/77) (N10 nuclear protein).

ESR2_MOUSE
NC score	0.942157 (rank : 41)	θ value	1.51715e-39 (rank : 38)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	96
SwissProt Accessions	O08537, O35635, O70519	Gene names	Esr2, Estrb, Nr3a2
Domain Architecture
Description	Estrogen receptor beta (ER-beta).

ESR1_MOUSE
NC score	0.937549 (rank : 42)	θ value	2.12192e-33 (rank : 49)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	P19785, Q9JJT5, Q9QY51, Q9QY52	Gene names	Esr1, Esr, Estr, Estra, Nr3a1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

ESR1_HUMAN
NC score	0.937500 (rank : 43)	θ value	7.29293e-34 (rank : 47)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	95
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

NR1H3_HUMAN
NC score	0.935842 (rank : 44)	θ value	2.12192e-33 (rank : 50)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	95
SwissProt Accessions	Q13133, Q96H87	Gene names	NR1H3, LXRA
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H4_HUMAN
NC score	0.935776 (rank : 45)	θ value	8.91499e-32 (rank : 58)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q96RI1, Q8NFP5, Q8NFP6, Q92943	Gene names	NR1H4, BAR, FXR, HRR1, RIP14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR1H3_MOUSE
NC score	0.935191 (rank : 46)	θ value	8.06329e-33 (rank : 56)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0Y9, Q9QUH7	Gene names	Nr1h3, Lxra
Domain Architecture
Description	Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha).

NR1H4_MOUSE
NC score	0.935141 (rank : 47)	θ value	1.52067e-31 (rank : 59)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	Q60641, Q60642, Q60643	Gene names	Nr1h4, Bar, Fxr, Rip14
Domain Architecture
Description	Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14).

NR6A1_HUMAN
NC score	0.933677 (rank : 48)	θ value	3.07116e-24 (rank : 82)
Query Neighborhood Hits	129	Target Neighborhood Hits	108	Shared Neighborhood Hits	98
SwissProt Accessions	Q15406, O00551, O00603, Q8NHQ0, Q92898, Q99802	Gene names	NR6A1, GCNF
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

TR2_HUMAN
NC score	0.933450 (rank : 49)	θ value	1.08979e-29 (rank : 65)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	97
SwissProt Accessions	P13056	Gene names	NR2C1, TR2
Domain Architecture
Description	Orphan nuclear receptor TR2 (Testicular receptor 2).

NR1I3_HUMAN
NC score	0.933185 (rank : 50)	θ value	1.37858e-24 (rank : 79)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	Q14994	Gene names	NR1I3, CAR
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Constitutive activator of retinoid response) (Constitutive active response) (Orphan nuclear receptor MB67).

NR6A1_MOUSE
NC score	0.932978 (rank : 51)	θ value	3.07116e-24 (rank : 83)
Query Neighborhood Hits	129	Target Neighborhood Hits	110	Shared Neighborhood Hits	98
SwissProt Accessions	Q64249	Gene names	Nr6a1, Gcnf
Domain Architecture
Description	Orphan nuclear receptor NR6A1 (Germ cell nuclear factor) (GCNF) (Retinoid receptor-related testis-specific receptor) (RTR).

THA_HUMAN
NC score	0.930903 (rank : 52)	θ value	3.73686e-38 (rank : 40)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

THA_MOUSE
NC score	0.930876 (rank : 53)	θ value	4.88048e-38 (rank : 41)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	97
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

TR2_MOUSE
NC score	0.930006 (rank : 54)	θ value	6.38894e-30 (rank : 64)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	98
SwissProt Accessions	Q505F1, P97763, Q3UIJ7, Q4U1Z4, Q60927, Q62152, Q8VIJ3	Gene names	Nr2c1, Tr2, Tr2-11
Domain Architecture	No domain graphic available
Description	Orphan nuclear receptor TR2 (Testicular receptor 2) (mTR2).

TR4_HUMAN
NC score	0.929768 (rank : 55)	θ value	1.98606e-31 (rank : 61)
Query Neighborhood Hits	129	Target Neighborhood Hits	117	Shared Neighborhood Hits	98
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

PPARA_HUMAN
NC score	0.929549 (rank : 56)	θ value	1.32909e-35 (rank : 44)
Query Neighborhood Hits	129	Target Neighborhood Hits	100	Shared Neighborhood Hits	94
SwissProt Accessions	Q07869, Q16241, Q92486, Q92689, Q9Y3N1	Gene names	PPARA, NR1C1, PPAR
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

TR4_MOUSE
NC score	0.929080 (rank : 57)	θ value	7.54701e-31 (rank : 62)
Query Neighborhood Hits	129	Target Neighborhood Hits	115	Shared Neighborhood Hits	98
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

NR1I3_MOUSE
NC score	0.928671 (rank : 58)	θ value	2.35151e-24 (rank : 81)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	98
SwissProt Accessions	O35627, O35628	Gene names	Nr1i3, Car
Domain Architecture
Description	Orphan nuclear receptor NR1I3 (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67).

PPARA_MOUSE
NC score	0.928371 (rank : 59)	θ value	4.72714e-33 (rank : 54)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	95
SwissProt Accessions	P23204	Gene names	Ppara, Nr1c1, Ppar
Domain Architecture
Description	Peroxisome proliferator-activated receptor alpha (PPAR-alpha).

NR5A2_MOUSE
NC score	0.927228 (rank : 60)	θ value	9.8567e-31 (rank : 63)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	98
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PPARD_HUMAN
NC score	0.925880 (rank : 61)	θ value	4.568e-36 (rank : 43)
Query Neighborhood Hits	129	Target Neighborhood Hits	102	Shared Neighborhood Hits	94
SwissProt Accessions	Q03181, Q7Z5K0, Q9BUD4	Gene names	PPARD, NR1C2, PPARB
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1) (NUCI).

NR5A2_HUMAN
NC score	0.925359 (rank : 62)	θ value	1.98606e-31 (rank : 60)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	98
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

THB2_HUMAN
NC score	0.925126 (rank : 63)	θ value	2.77131e-33 (rank : 53)
Query Neighborhood Hits	129	Target Neighborhood Hits	104	Shared Neighborhood Hits	98
SwissProt Accessions	P37243	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor beta-2.

STF1_MOUSE
NC score	0.924680 (rank : 64)	θ value	8.08199e-25 (rank : 76)
Query Neighborhood Hits	129	Target Neighborhood Hits	137	Shared Neighborhood Hits	99
SwissProt Accessions	P33242	Gene names	Nr5a1, Ftzf1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1) (Embryonal LTR-binding protein) (ELP) (Embryonal long terminal repeat- binding protein) (Steroid hydroxylase positive regulator).

THB1_HUMAN
NC score	0.924665 (rank : 65)	θ value	1.6247e-33 (rank : 48)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P10828, Q13986	Gene names	THRB, ERBA2, NR1A2, THR1
Domain Architecture
Description	Thyroid hormone receptor beta-1.

PPARD_MOUSE
NC score	0.924136 (rank : 66)	θ value	1.08726e-37 (rank : 42)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	94
SwissProt Accessions	P35396, P37239	Gene names	Ppard, Nr1c2, Pparb
Domain Architecture
Description	Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR- beta) (Nuclear hormone receptor 1) (NUC1).

NR1H2_MOUSE
NC score	0.923784 (rank : 67)	θ value	2.68423e-28 (rank : 67)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	97
SwissProt Accessions	Q60644	Gene names	Nr1h2, Lxrb, Rip15, Unr, Unr2
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Retinoid X receptor-interacting protein No.15).

THB2_MOUSE
NC score	0.923783 (rank : 68)	θ value	2.12192e-33 (rank : 52)
Query Neighborhood Hits	129	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	P37244	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-2.

THB1_MOUSE
NC score	0.923757 (rank : 69)	θ value	2.12192e-33 (rank : 51)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	98
SwissProt Accessions	P37242	Gene names	Thrb, C-erba-beta, Nr1a2
Domain Architecture
Description	Thyroid hormone receptor beta-1.

PPARG_HUMAN
NC score	0.923592 (rank : 70)	θ value	4.72714e-33 (rank : 55)
Query Neighborhood Hits	129	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37231, O00684, O00710, O14515, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12	Gene names	PPARG, NR1C3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

PPARG_MOUSE
NC score	0.923161 (rank : 71)	θ value	1.0531e-32 (rank : 57)
Query Neighborhood Hits	129	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	P37238	Gene names	Pparg, Nr1c3
Domain Architecture
Description	Peroxisome proliferator-activated receptor gamma (PPAR-gamma).

STF1_HUMAN
NC score	0.922643 (rank : 72)	θ value	8.08199e-25 (rank : 75)
Query Neighborhood Hits	129	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q13285, O15196	Gene names	NR5A1, AD4BP, FTZF1, SF1
Domain Architecture
Description	Steroidogenic factor 1 (STF-1) (SF-1) (Adrenal 4-binding protein) (Steroid hormone receptor Ad4BP) (Fushi tarazu factor homolog 1).

NR1D1_HUMAN
NC score	0.917887 (rank : 73)	θ value	1.42661e-21 (rank : 92)
Query Neighborhood Hits	129	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	P20393, Q15304	Gene names	NR1D1, EAR1, HREV, THRAL
Domain Architecture
Description	Orphan nuclear receptor NR1D1 (V-erbA-related protein EAR-1) (Rev- erbA-alpha).

NR1H2_HUMAN
NC score	0.917634 (rank : 74)	θ value	3.17079e-29 (rank : 66)
Query Neighborhood Hits	129	Target Neighborhood Hits	114	Shared Neighborhood Hits	95
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PXR_MOUSE
NC score	0.912917 (rank : 75)	θ value	2.51237e-26 (rank : 68)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O54915	Gene names	Nr1i2, Pxr
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor).

NR1D2_HUMAN
NC score	0.911295 (rank : 76)	θ value	9.87957e-23 (rank : 88)
Query Neighborhood Hits	129	Target Neighborhood Hits	115	Shared Neighborhood Hits	94
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

PXR_HUMAN
NC score	0.910356 (rank : 77)	θ value	3.07116e-24 (rank : 84)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	97
SwissProt Accessions	O75469, Q96AC7, Q9UJ22, Q9UJ23, Q9UJ24, Q9UJ25, Q9UJ26, Q9UJ27	Gene names	NR1I2, PXR
Domain Architecture
Description	Orphan nuclear receptor PXR (Pregnane X receptor) (Orphan nuclear receptor PAR1) (Steroid and xenobiotic receptor) (SXR).

VDR_MOUSE
NC score	0.909664 (rank : 78)	θ value	1.47631e-18 (rank : 93)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	96
SwissProt Accessions	P48281	Gene names	Vdr, Nr1i1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

VDR_HUMAN
NC score	0.909520 (rank : 79)	θ value	7.32683e-18 (rank : 94)
Query Neighborhood Hits	129	Target Neighborhood Hits	112	Shared Neighborhood Hits	96
SwissProt Accessions	P11473	Gene names	VDR, NR1I1
Domain Architecture
Description	Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor).

NR1D2_MOUSE
NC score	0.908662 (rank : 80)	θ value	2.20094e-22 (rank : 90)
Query Neighborhood Hits	129	Target Neighborhood Hits	109	Shared Neighborhood Hits	94
SwissProt Accessions	Q60674, Q60646	Gene names	Nr1d2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (Orphan nuclear receptor RVR).

RORG_MOUSE
NC score	0.905339 (rank : 81)	θ value	1.16704e-23 (rank : 86)
Query Neighborhood Hits	129	Target Neighborhood Hits	107	Shared Neighborhood Hits	94
SwissProt Accessions	P51450, Q61027, Q91YT5, Q9QXD9, Q9R177	Gene names	Rorc, Nr1f3, Rorg, Thor
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Thymus orphan receptor) (TOR).

RORB_MOUSE
NC score	0.903456 (rank : 82)	θ value	1.05554e-24 (rank : 78)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q8R1B8	Gene names	Rorb, Nr1f2
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORB_HUMAN
NC score	0.903453 (rank : 83)	θ value	1.05554e-24 (rank : 77)
Query Neighborhood Hits	129	Target Neighborhood Hits	99	Shared Neighborhood Hits	94
SwissProt Accessions	Q92753, Q8WX73	Gene names	RORB, NR1F2, RZRB
Domain Architecture
Description	Nuclear receptor ROR-beta (Nuclear receptor RZR-beta).

RORA_HUMAN
NC score	0.903330 (rank : 84)	θ value	2.12685e-25 (rank : 71)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P35398, P35397, P35399, P45445, Q96H83	Gene names	RORA, NR1F1, RZRA
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORA_MOUSE
NC score	0.902773 (rank : 85)	θ value	2.12685e-25 (rank : 72)
Query Neighborhood Hits	129	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	P51448, P70283, P97741, P97773, Q923G1	Gene names	Rora, Nr1f1, Rzra
Domain Architecture
Description	Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha).

RORG_HUMAN
NC score	0.901934 (rank : 86)	θ value	4.01107e-24 (rank : 85)
Query Neighborhood Hits	129	Target Neighborhood Hits	119	Shared Neighborhood Hits	95
SwissProt Accessions	P51449, Q8N5V7, Q8NCY8	Gene names	RORC, NR1F3, RORG, RZRG
Domain Architecture
Description	Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma).

GCR_HUMAN
NC score	0.888049 (rank : 87)	θ value	1.62847e-25 (rank : 70)
Query Neighborhood Hits	129	Target Neighborhood Hits	113	Shared Neighborhood Hits	94
SwissProt Accessions	P04150, P04151, Q53EP5, Q6N0A4	Gene names	NR3C1, GRL
Domain Architecture
Description	Glucocorticoid receptor (GR).

ANDR_MOUSE
NC score	0.886162 (rank : 88)	θ value	7.30988e-26 (rank : 69)
Query Neighborhood Hits	129	Target Neighborhood Hits	133	Shared Neighborhood Hits	94
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ANDR_HUMAN
NC score	0.883758 (rank : 89)	θ value	1.29031e-22 (rank : 89)
Query Neighborhood Hits	129	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	P10275	Gene names	AR, DHTR, NR3C4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

GCR_MOUSE
NC score	0.882112 (rank : 90)	θ value	6.18819e-25 (rank : 74)
Query Neighborhood Hits	129	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P06537, Q61628, Q61629	Gene names	Nr3c1, Grl, Grl1
Domain Architecture
Description	Glucocorticoid receptor (GR).

MCR_HUMAN
NC score	0.880550 (rank : 91)	θ value	1.99067e-23 (rank : 87)
Query Neighborhood Hits	129	Target Neighborhood Hits	149	Shared Neighborhood Hits	95
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

PRGR_HUMAN
NC score	0.877533 (rank : 92)	θ value	1.80048e-24 (rank : 80)
Query Neighborhood Hits	129	Target Neighborhood Hits	163	Shared Neighborhood Hits	98
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

MCR_MOUSE
NC score	0.875998 (rank : 93)	θ value	8.36355e-22 (rank : 91)
Query Neighborhood Hits	129	Target Neighborhood Hits	162	Shared Neighborhood Hits	97
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PRGR_MOUSE
NC score	0.872562 (rank : 94)	θ value	3.62785e-25 (rank : 73)
Query Neighborhood Hits	129	Target Neighborhood Hits	286	Shared Neighborhood Hits	97
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SHP_HUMAN
NC score	0.599346 (rank : 95)	θ value	8.67504e-11 (rank : 95)
Query Neighborhood Hits	129	Target Neighborhood Hits	57	Shared Neighborhood Hits	56
SwissProt Accessions	Q15466, Q5QP36	Gene names	NR0B2, SHP
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

SHP_MOUSE
NC score	0.588598 (rank : 96)	θ value	2.52405e-10 (rank : 97)
Query Neighborhood Hits	129	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q62227, Q53Z53	Gene names	Nr0b2, Shp
Domain Architecture
Description	Nuclear receptor 0B2 (Orphan nuclear receptor SHP) (Small heterodimer partner).

DAX1_MOUSE
NC score	0.580676 (rank : 97)	θ value	4.30538e-10 (rank : 98)
Query Neighborhood Hits	129	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q61066, O09068, O09147	Gene names	Nr0b1, Ahch, Dax1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1).

DAX1_HUMAN
NC score	0.557979 (rank : 98)	θ value	1.47974e-10 (rank : 96)
Query Neighborhood Hits	129	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	P51843, Q96F69	Gene names	NR0B1, AHC, DAX1
Domain Architecture
Description	Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).

BCL9_MOUSE
NC score	0.043562 (rank : 99)	θ value	0.0252991 (rank : 101)
Query Neighborhood Hits	129	Target Neighborhood Hits	770	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BCL9_HUMAN
NC score	0.034600 (rank : 100)	θ value	0.0193708 (rank : 100)
Query Neighborhood Hits	129	Target Neighborhood Hits	1008	Shared Neighborhood Hits	19
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

EP300_HUMAN
NC score	0.029465 (rank : 101)	θ value	0.0148317 (rank : 99)
Query Neighborhood Hits	129	Target Neighborhood Hits	821	Shared Neighborhood Hits	20
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

CBP_MOUSE
NC score	0.026958 (rank : 102)	θ value	0.279714 (rank : 103)
Query Neighborhood Hits	129	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_HUMAN
NC score	0.025172 (rank : 103)	θ value	0.365318 (rank : 104)
Query Neighborhood Hits	129	Target Neighborhood Hits	941	Shared Neighborhood Hits	21
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MA2C1_HUMAN
NC score	0.024500 (rank : 104)	θ value	0.47712 (rank : 105)
Query Neighborhood Hits	129	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

MA2C1_MOUSE
NC score	0.020624 (rank : 105)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	129	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

WFS1_HUMAN
NC score	0.018278 (rank : 106)	θ value	1.06291 (rank : 110)
Query Neighborhood Hits	129	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

PER3_HUMAN
NC score	0.016025 (rank : 107)	θ value	0.62314 (rank : 107)
Query Neighborhood Hits	129	Target Neighborhood Hits	479	Shared Neighborhood Hits	18
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

BRD7_HUMAN
NC score	0.014900 (rank : 108)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	129	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

BRD7_MOUSE
NC score	0.014304 (rank : 109)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	129	Target Neighborhood Hits	141	Shared Neighborhood Hits	7
SwissProt Accessions	O88665, Q3UQ56, Q3UU06, Q9CT78	Gene names	Brd7, Bp75
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein).

MAGE1_HUMAN
NC score	0.014132 (rank : 110)	θ value	0.21417 (rank : 102)
Query Neighborhood Hits	129	Target Neighborhood Hits	1389	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SON_HUMAN
NC score	0.009735 (rank : 111)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	129	Target Neighborhood Hits	1568	Shared Neighborhood Hits	26
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

AP180_HUMAN
NC score	0.009423 (rank : 112)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	129	Target Neighborhood Hits	183	Shared Neighborhood Hits	15
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

ZCHC8_HUMAN
NC score	0.009263 (rank : 113)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	129	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZY4, Q7L2P6, Q8N2K5, Q96SK7, Q9NSS2, Q9NSS3	Gene names	ZCCHC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

S23IP_MOUSE
NC score	0.008896 (rank : 114)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	129	Target Neighborhood Hits	363	Shared Neighborhood Hits	13
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

NASP_HUMAN
NC score	0.008613 (rank : 115)	θ value	0.47712 (rank : 106)
Query Neighborhood Hits	129	Target Neighborhood Hits	709	Shared Neighborhood Hits	8
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

4ET_MOUSE
NC score	0.008307 (rank : 116)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	129	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

TLE1_MOUSE
NC score	0.006817 (rank : 117)	θ value	0.62314 (rank : 108)
Query Neighborhood Hits	129	Target Neighborhood Hits	491	Shared Neighborhood Hits	13
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

FUBP1_HUMAN
NC score	0.006317 (rank : 118)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	129	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

FUBP1_MOUSE
NC score	0.006283 (rank : 119)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	129	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

TLE1_HUMAN
NC score	0.005186 (rank : 120)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	129	Target Neighborhood Hits	485	Shared Neighborhood Hits	11
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

MUC2_HUMAN
NC score	0.004142 (rank : 121)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	129	Target Neighborhood Hits	906	Shared Neighborhood Hits	16
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

HCFC1_MOUSE
NC score	0.002730 (rank : 122)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	129	Target Neighborhood Hits	348	Shared Neighborhood Hits	9
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCFC1_HUMAN
NC score	0.002697 (rank : 123)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	129	Target Neighborhood Hits	331	Shared Neighborhood Hits	8
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

ARNT_MOUSE
NC score	0.002564 (rank : 124)	θ value	3.0926 (rank : 117)
Query Neighborhood Hits	129	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

PRDM2_HUMAN
NC score	-0.004157 (rank : 125)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	129	Target Neighborhood Hits	1135	Shared Neighborhood Hits	13
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

WNK4_HUMAN
NC score	-0.004328 (rank : 126)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	129	Target Neighborhood Hits	1043	Shared Neighborhood Hits	12
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

GLIS1_MOUSE
NC score	-0.005259 (rank : 127)	θ value	0.813845 (rank : 109)
Query Neighborhood Hits	129	Target Neighborhood Hits	751	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).

KPCD1_HUMAN
NC score	-0.007994 (rank : 128)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	129	Target Neighborhood Hits	901	Shared Neighborhood Hits	5
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

NEK3_MOUSE
NC score	-0.008983 (rank : 129)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	129	Target Neighborhood Hits	854	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).