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Network neighborhood for query Sequence : MA2C1_HUMAN

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MA2C1_HUMAN
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MA2C1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

MA2C1_MOUSE
θ value	0 (rank : 2)	NC score	0.996037 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

MA2A1_MOUSE
θ value	5.44631e-05 (rank : 3)	NC score	0.266949 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A1_HUMAN
θ value	7.1131e-05 (rank : 4)	NC score	0.258989 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A2_HUMAN
θ value	0.000158464 (rank : 5)	NC score	0.254354 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2B2_HUMAN
θ value	0.000461057 (rank : 6)	NC score	0.242046 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_MOUSE
θ value	0.000602161 (rank : 7)	NC score	0.239104 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B1_MOUSE
θ value	0.125558 (rank : 8)	NC score	0.199083 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MAVS_MOUSE
θ value	0.279714 (rank : 9)	NC score	0.056146 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

RXRA_HUMAN
θ value	0.279714 (rank : 10)	NC score	0.026228 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_MOUSE
θ value	0.47712 (rank : 11)	NC score	0.024500 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

GAMT_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.066571 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O35969, Q3TZ58, Q3US90	Gene names	Gamt
Domain Architecture	No domain graphic available
Description	Guanidinoacetate N-methyltransferase (EC 2.1.1.2).

CU070_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.059572 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P58468	Gene names
Domain Architecture	No domain graphic available
Description	Protein C21orf70 homolog.

NU155_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.021175 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O75694, Q9UBE9, Q9UFL5	Gene names	NUP155, KIAA0791
Domain Architecture
Description	Nuclear pore complex protein Nup155 (Nucleoporin Nup155) (155 kDa nucleoporin).

ZMYM3_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.016112 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	223	Shared Neighborhood Hits	2
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

PK3CD_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.013841 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.013880 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

KIF6_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.012031 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.

TULP4_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.011203 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	426	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

NFYC_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.014953 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q13952, Q5T6K8, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7	Gene names	NFYC
Domain Architecture
Description	Nuclear transcription factor Y subunit gamma (Nuclear transcription factor Y subunit C) (NF-YC) (CAAT-box DNA-binding protein subunit C) (Transactivator HSM-1/2).

SL9A6_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.007955 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q92581	Gene names	SLC9A6, KIAA0267, NHE6
Domain Architecture
Description	Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6).

MA2B1_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.167600 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

Hits sorted by NC score

MA2C1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

MA2C1_MOUSE
NC score	0.996037 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	13
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

MA2A1_MOUSE
NC score	0.266949 (rank : 3)	θ value	5.44631e-05 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A1_HUMAN
NC score	0.258989 (rank : 4)	θ value	7.1131e-05 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A2_HUMAN
NC score	0.254354 (rank : 5)	θ value	0.000158464 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2B2_HUMAN
NC score	0.242046 (rank : 6)	θ value	0.000461057 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_MOUSE
NC score	0.239104 (rank : 7)	θ value	0.000602161 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B1_MOUSE
NC score	0.199083 (rank : 8)	θ value	0.125558 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MA2B1_HUMAN
NC score	0.167600 (rank : 9)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

GAMT_MOUSE
NC score	0.066571 (rank : 10)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O35969, Q3TZ58, Q3US90	Gene names	Gamt
Domain Architecture	No domain graphic available
Description	Guanidinoacetate N-methyltransferase (EC 2.1.1.2).

CU070_MOUSE
NC score	0.059572 (rank : 11)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P58468	Gene names
Domain Architecture	No domain graphic available
Description	Protein C21orf70 homolog.

MAVS_MOUSE
NC score	0.056146 (rank : 12)	θ value	0.279714 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

RXRA_HUMAN
NC score	0.026228 (rank : 13)	θ value	0.279714 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	P19793, Q2V504	Gene names	RXRA, NR2B1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

RXRA_MOUSE
NC score	0.024500 (rank : 14)	θ value	0.47712 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	P28700	Gene names	Rxra, Nr2b1
Domain Architecture
Description	Retinoic acid receptor RXR-alpha (Retinoid X receptor alpha).

NU155_HUMAN
NC score	0.021175 (rank : 15)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O75694, Q9UBE9, Q9UFL5	Gene names	NUP155, KIAA0791
Domain Architecture
Description	Nuclear pore complex protein Nup155 (Nucleoporin Nup155) (155 kDa nucleoporin).

ZMYM3_HUMAN
NC score	0.016112 (rank : 16)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	223	Shared Neighborhood Hits	2
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

NFYC_HUMAN
NC score	0.014953 (rank : 17)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q13952, Q5T6K8, Q5T6L1, Q5TZR6, Q92869, Q9HBX1, Q9NXB5, Q9UM67, Q9UML0, Q9UMT7	Gene names	NFYC
Domain Architecture
Description	Nuclear transcription factor Y subunit gamma (Nuclear transcription factor Y subunit C) (NF-YC) (CAAT-box DNA-binding protein subunit C) (Transactivator HSM-1/2).

PK3CD_MOUSE
NC score	0.013880 (rank : 18)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
NC score	0.013841 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

KIF6_HUMAN
NC score	0.012031 (rank : 20)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMV9, Q2MDE3, Q2MDE4, Q5T8J6, Q6ZWE3, Q86T87, Q8WTV4	Gene names	KIF6, C6orf102
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF6.

TULP4_HUMAN
NC score	0.011203 (rank : 21)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	426	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

SL9A6_HUMAN
NC score	0.007955 (rank : 22)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q92581	Gene names	SLC9A6, KIAA0267, NHE6
Domain Architecture
Description	Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6).