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Network neighborhood for query Sequence : MA1C1_HUMAN

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MA1C1_HUMAN
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MA1A1_HUMAN
θ value	0 (rank : 1)	NC score	0.990346 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A1_MOUSE
θ value	0 (rank : 2)	NC score	0.989144 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1C1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MA1A2_HUMAN
θ value	1.04765e-165 (rank : 4)	NC score	0.988076 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A2_MOUSE
θ value	1.19867e-161 (rank : 5)	NC score	0.988042 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1B1_HUMAN
θ value	1.40038e-85 (rank : 6)	NC score	0.934773 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

EDEM2_HUMAN
θ value	6.58091e-43 (rank : 7)	NC score	0.881438 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

EDEM1_HUMAN
θ value	2.19075e-38 (rank : 8)	NC score	0.842247 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_MOUSE
θ value	6.37413e-38 (rank : 9)	NC score	0.841424 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM3_HUMAN
θ value	3.86705e-35 (rank : 10)	NC score	0.829305 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

ZN197_HUMAN
θ value	0.0961366 (rank : 11)	NC score	0.002367 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	788	Shared Neighborhood Hits	3
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

OGFR_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.013395 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1582	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SPEG_HUMAN
θ value	0.62314 (rank : 13)	NC score	0.002824 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	1762	Shared Neighborhood Hits	6
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZFP28_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.001207 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	843	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHY6, Q9BY30, Q9P2B6	Gene names	ZFP28, KIAA1431
Domain Architecture
Description	Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6).

TACC3_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.012176 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	779	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

COG8_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.018238 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

MDC1_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.009761 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	998	Shared Neighborhood Hits	8
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

AKA12_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.010440 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	825	Shared Neighborhood Hits	6
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

MAST4_HUMAN
θ value	8.99809 (rank : 19)	NC score	-0.000854 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1804	Shared Neighborhood Hits	8
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NCOAT_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.008652 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

SEPT9_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.004296 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

Hits sorted by NC score

MA1C1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MA1A1_HUMAN
NC score	0.990346 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A1_MOUSE
NC score	0.989144 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A2_HUMAN
NC score	0.988076 (rank : 4)	θ value	1.04765e-165 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A2_MOUSE
NC score	0.988042 (rank : 5)	θ value	1.19867e-161 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1B1_HUMAN
NC score	0.934773 (rank : 6)	θ value	1.40038e-85 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

EDEM2_HUMAN
NC score	0.881438 (rank : 7)	θ value	6.58091e-43 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

EDEM1_HUMAN
NC score	0.842247 (rank : 8)	θ value	2.19075e-38 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_MOUSE
NC score	0.841424 (rank : 9)	θ value	6.37413e-38 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM3_HUMAN
NC score	0.829305 (rank : 10)	θ value	3.86705e-35 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

COG8_MOUSE
NC score	0.018238 (rank : 11)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	147	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

OGFR_HUMAN
NC score	0.013395 (rank : 12)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1582	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TACC3_HUMAN
NC score	0.012176 (rank : 13)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	779	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

AKA12_HUMAN
NC score	0.010440 (rank : 14)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	825	Shared Neighborhood Hits	6
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

MDC1_MOUSE
NC score	0.009761 (rank : 15)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	998	Shared Neighborhood Hits	8
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NCOAT_HUMAN
NC score	0.008652 (rank : 16)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0	Gene names	MGEA5, HEXC, KIAA0679, MEA5
Domain Architecture	No domain graphic available
Description	Bifunctional protein NCOAT (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (Meningioma-expressed antigen 5) [Includes: Beta- hexosaminidase (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) (Beta-N- acetylhexosaminidase) (Hexosaminidase C) (N-acetyl-beta-D- glucosaminidase) (O-GlcNAcase); Histone acetyltransferase (EC 2.3.1.48) (HAT)].

SEPT9_HUMAN
NC score	0.004296 (rank : 17)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	706	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SPEG_HUMAN
NC score	0.002824 (rank : 18)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	1762	Shared Neighborhood Hits	6
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZN197_HUMAN
NC score	0.002367 (rank : 19)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	788	Shared Neighborhood Hits	3
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

ZFP28_HUMAN
NC score	0.001207 (rank : 20)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	843	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NHY6, Q9BY30, Q9P2B6	Gene names	ZFP28, KIAA1431
Domain Architecture
Description	Zinc finger protein 28 homolog (Zfp-28) (Krueppel-like zinc finger factor X6).

MAST4_HUMAN
NC score	-0.000854 (rank : 21)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1804	Shared Neighborhood Hits	8
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).