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Network neighborhood for query Sequence : EDEM1_MOUSE

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EDEM1_MOUSE
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EDEM1_HUMAN
θ value	0 (rank : 1)	NC score	0.996604 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM3_HUMAN
θ value	1.43912e-106 (rank : 3)	NC score	0.928802 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

EDEM2_HUMAN
θ value	3.21347e-98 (rank : 4)	NC score	0.960813 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

MA1B1_HUMAN
θ value	5.20228e-48 (rank : 5)	NC score	0.860645 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MA1A2_HUMAN
θ value	3.85808e-43 (rank : 6)	NC score	0.837837 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A1_MOUSE
θ value	8.59492e-43 (rank : 7)	NC score	0.839065 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A2_MOUSE
θ value	6.15952e-41 (rank : 8)	NC score	0.834665 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A1_HUMAN
θ value	8.04462e-41 (rank : 9)	NC score	0.837971 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1C1_HUMAN
θ value	6.37413e-38 (rank : 10)	NC score	0.841424 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

OCLN_MOUSE
θ value	0.00228821 (rank : 11)	NC score	0.083418 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	Q61146, Q544A7	Gene names	Ocln, Ocl
Domain Architecture
Description	Occludin.

OCLN_HUMAN
θ value	0.21417 (rank : 12)	NC score	0.067511 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

STK10_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.004019 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	1921	Shared Neighborhood Hits	3
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	0.47712 (rank : 14)	NC score	0.003530 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	2132	Shared Neighborhood Hits	3
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DOCK2_HUMAN
θ value	1.38821 (rank : 15)	NC score	0.022642 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

CO7A1_HUMAN
θ value	2.36792 (rank : 16)	NC score	0.004476 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	807	Shared Neighborhood Hits	3
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

DOCK2_MOUSE
θ value	4.03905 (rank : 17)	NC score	0.016451 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

TCGAP_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.005589 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	872	Shared Neighborhood Hits	3
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

K1718_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.011723 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

RP1L1_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.028875 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

CO4A4_HUMAN
θ value	6.88961 (rank : 21)	NC score	0.004862 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	440	Shared Neighborhood Hits	4
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

PSG4_HUMAN
θ value	6.88961 (rank : 22)	NC score	0.005758 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

TSNA1_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.008650 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

PAP21_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.052740 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

PAP21_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.052768 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

Hits sorted by NC score

EDEM1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	23	Target Neighborhood Hits	23	Shared Neighborhood Hits	23
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_HUMAN
NC score	0.996604 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	23	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM2_HUMAN
NC score	0.960813 (rank : 3)	θ value	3.21347e-98 (rank : 4)
Query Neighborhood Hits	23	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

EDEM3_HUMAN
NC score	0.928802 (rank : 4)	θ value	1.43912e-106 (rank : 3)
Query Neighborhood Hits	23	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

MA1B1_HUMAN
NC score	0.860645 (rank : 5)	θ value	5.20228e-48 (rank : 5)
Query Neighborhood Hits	23	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MA1C1_HUMAN
NC score	0.841424 (rank : 6)	θ value	6.37413e-38 (rank : 10)
Query Neighborhood Hits	23	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MA1A1_MOUSE
NC score	0.839065 (rank : 7)	θ value	8.59492e-43 (rank : 7)
Query Neighborhood Hits	23	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A1_HUMAN
NC score	0.837971 (rank : 8)	θ value	8.04462e-41 (rank : 9)
Query Neighborhood Hits	23	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A2_HUMAN
NC score	0.837837 (rank : 9)	θ value	3.85808e-43 (rank : 6)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A2_MOUSE
NC score	0.834665 (rank : 10)	θ value	6.15952e-41 (rank : 8)
Query Neighborhood Hits	23	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

OCLN_MOUSE
NC score	0.083418 (rank : 11)	θ value	0.00228821 (rank : 11)
Query Neighborhood Hits	23	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	Q61146, Q544A7	Gene names	Ocln, Ocl
Domain Architecture
Description	Occludin.

OCLN_HUMAN
NC score	0.067511 (rank : 12)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	23	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

PAP21_MOUSE
NC score	0.052768 (rank : 13)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

PAP21_HUMAN
NC score	0.052740 (rank : 14)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	23	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

RP1L1_MOUSE
NC score	0.028875 (rank : 15)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	23	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

DOCK2_HUMAN
NC score	0.022642 (rank : 16)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	23	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.016451 (rank : 17)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	23	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

K1718_HUMAN
NC score	0.011723 (rank : 18)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	23	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

TSNA1_HUMAN
NC score	0.008650 (rank : 19)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	23	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NA8	Gene names	TSNARE1
Domain Architecture	No domain graphic available
Description	t-SNARE domain-containing protein 1.

PSG4_HUMAN
NC score	0.005758 (rank : 20)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	23	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

TCGAP_HUMAN
NC score	0.005589 (rank : 21)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	23	Target Neighborhood Hits	872	Shared Neighborhood Hits	3
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CO4A4_HUMAN
NC score	0.004862 (rank : 22)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	23	Target Neighborhood Hits	440	Shared Neighborhood Hits	4
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CO7A1_HUMAN
NC score	0.004476 (rank : 23)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	23	Target Neighborhood Hits	807	Shared Neighborhood Hits	3
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

STK10_HUMAN
NC score	0.004019 (rank : 24)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	23	Target Neighborhood Hits	1921	Shared Neighborhood Hits	3
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
NC score	0.003530 (rank : 25)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	23	Target Neighborhood Hits	2132	Shared Neighborhood Hits	3
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).