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Network neighborhood for query Sequence : PI3R4_HUMAN

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PI3R4_HUMAN
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PI3R4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	534	Target Neighborhood Hits	534	Shared Neighborhood Hits	534
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	0 (rank : 2)	NC score	0.985984 (rank : 2)
Query Neighborhood Hits	534	Target Neighborhood Hits	535	Shared Neighborhood Hits	490
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

NUAK1_MOUSE
θ value	9.92553e-07 (rank : 3)	NC score	0.407013 (rank : 21)
Query Neighborhood Hits	534	Target Neighborhood Hits	881	Shared Neighborhood Hits	344
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

WD51A_HUMAN
θ value	1.69304e-06 (rank : 4)	NC score	0.258529 (rank : 622)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NBT0, Q2TAK6, Q96IK6, Q9UFJ8	Gene names	WDR51A
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

CDKL5_HUMAN
θ value	3.77169e-06 (rank : 5)	NC score	0.396599 (rank : 79)
Query Neighborhood Hits	534	Target Neighborhood Hits	967	Shared Neighborhood Hits	345
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MELK_HUMAN
θ value	4.92598e-06 (rank : 6)	NC score	0.413670 (rank : 5)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

NUAK1_HUMAN
θ value	4.92598e-06 (rank : 7)	NC score	0.405508 (rank : 24)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	345
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK2_HUMAN
θ value	4.92598e-06 (rank : 8)	NC score	0.404062 (rank : 35)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	6.43352e-06 (rank : 9)	NC score	0.408919 (rank : 14)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

WD51A_MOUSE
θ value	1.09739e-05 (rank : 10)	NC score	0.254878 (rank : 626)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZX3, Q9CY09	Gene names	Wdr51a
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

SN1L1_MOUSE
θ value	1.43324e-05 (rank : 11)	NC score	0.409033 (rank : 13)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	344
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

PDPK1_MOUSE
θ value	3.19293e-05 (rank : 12)	NC score	0.403441 (rank : 44)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

M3K5_HUMAN
θ value	5.44631e-05 (rank : 13)	NC score	0.379082 (rank : 202)
Query Neighborhood Hits	534	Target Neighborhood Hits	868	Shared Neighborhood Hits	342
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	5.44631e-05 (rank : 14)	NC score	0.378877 (rank : 204)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	342
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PDPK1_HUMAN
θ value	5.44631e-05 (rank : 15)	NC score	0.402919 (rank : 45)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

SN1L2_MOUSE
θ value	7.1131e-05 (rank : 16)	NC score	0.404080 (rank : 34)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	345
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

GEMI5_MOUSE
θ value	9.29e-05 (rank : 17)	NC score	0.237688 (rank : 659)
Query Neighborhood Hits	534	Target Neighborhood Hits	424	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

KS6A4_HUMAN
θ value	0.000121331 (rank : 18)	NC score	0.402848 (rank : 46)
Query Neighborhood Hits	534	Target Neighborhood Hits	868	Shared Neighborhood Hits	344
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

NEK9_HUMAN
θ value	0.000121331 (rank : 19)	NC score	0.368594 (rank : 279)
Query Neighborhood Hits	534	Target Neighborhood Hits	900	Shared Neighborhood Hits	343
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	0.000121331 (rank : 20)	NC score	0.369389 (rank : 265)
Query Neighborhood Hits	534	Target Neighborhood Hits	890	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

MELK_MOUSE
θ value	0.000158464 (rank : 21)	NC score	0.410618 (rank : 9)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	345
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

WD51B_MOUSE
θ value	0.000158464 (rank : 22)	NC score	0.250109 (rank : 635)
Query Neighborhood Hits	534	Target Neighborhood Hits	321	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BHD1	Gene names	Wdr51b
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

AAPK2_HUMAN
θ value	0.00020696 (rank : 23)	NC score	0.404653 (rank : 32)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

SN1L1_HUMAN
θ value	0.000270298 (rank : 24)	NC score	0.405977 (rank : 23)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	344
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

CHK2_MOUSE
θ value	0.00035302 (rank : 25)	NC score	0.411729 (rank : 8)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	343
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

WD51B_HUMAN
θ value	0.00035302 (rank : 26)	NC score	0.245718 (rank : 647)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TC44	Gene names	WDR51B
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

AAPK1_HUMAN
θ value	0.000461057 (rank : 27)	NC score	0.402636 (rank : 48)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	0.000461057 (rank : 28)	NC score	0.402727 (rank : 47)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AKT3_HUMAN
θ value	0.000461057 (rank : 29)	NC score	0.396085 (rank : 88)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	0.000461057 (rank : 30)	NC score	0.396106 (rank : 87)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KCC1B_HUMAN
θ value	0.000461057 (rank : 31)	NC score	0.407129 (rank : 20)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

M3K4_HUMAN
θ value	0.000461057 (rank : 32)	NC score	0.383511 (rank : 169)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	346
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	0.000461057 (rank : 33)	NC score	0.382768 (rank : 175)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	347
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

SN1L2_HUMAN
θ value	0.000461057 (rank : 34)	NC score	0.402540 (rank : 49)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	346
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

CDKL1_MOUSE
θ value	0.000602161 (rank : 35)	NC score	0.394017 (rank : 92)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

GEMI5_HUMAN
θ value	0.000602161 (rank : 36)	NC score	0.226238 (rank : 718)
Query Neighborhood Hits	534	Target Neighborhood Hits	362	Shared Neighborhood Hits	141
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

KS6A4_MOUSE
θ value	0.000602161 (rank : 37)	NC score	0.401513 (rank : 54)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MK15_MOUSE
θ value	0.000602161 (rank : 38)	NC score	0.390205 (rank : 114)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

NIM1_MOUSE
θ value	0.000602161 (rank : 39)	NC score	0.405128 (rank : 27)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

CDKL1_HUMAN
θ value	0.000786445 (rank : 40)	NC score	0.393942 (rank : 94)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

PHKG1_HUMAN
θ value	0.000786445 (rank : 41)	NC score	0.414652 (rank : 4)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PLRG1_MOUSE
θ value	0.000786445 (rank : 42)	NC score	0.248582 (rank : 641)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	143
SwissProt Accessions	Q922V4, O55039	Gene names	Plrg1
Domain Architecture
Description	Pleiotropic regulator 1.

APAF_HUMAN
θ value	0.00102713 (rank : 43)	NC score	0.246877 (rank : 644)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	147
SwissProt Accessions	O14727, O43297, Q7Z438, Q9BXZ6, Q9UBZ5, Q9UGN8, Q9UGN9, Q9UGP0, Q9UJ58, Q9UJ59, Q9UJ60, Q9UJ61, Q9UJ62, Q9UJ63, Q9UJ64, Q9UJ65, Q9UJ66, Q9UJ67, Q9UNC9	Gene names	APAF1, KIAA0413
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

KCC1B_MOUSE
θ value	0.00102713 (rank : 44)	NC score	0.406279 (rank : 22)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

MOK_HUMAN
θ value	0.00102713 (rank : 45)	NC score	0.384696 (rank : 160)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	341
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

PAK6_HUMAN
θ value	0.00102713 (rank : 46)	NC score	0.375347 (rank : 220)
Query Neighborhood Hits	534	Target Neighborhood Hits	915	Shared Neighborhood Hits	345
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PHKG2_HUMAN
θ value	0.00102713 (rank : 47)	NC score	0.414900 (rank : 3)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

SGK1_HUMAN
θ value	0.00102713 (rank : 48)	NC score	0.393196 (rank : 98)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

CD2L5_HUMAN
θ value	0.00175202 (rank : 49)	NC score	0.373558 (rank : 226)
Query Neighborhood Hits	534	Target Neighborhood Hits	987	Shared Neighborhood Hits	344
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	0.00175202 (rank : 50)	NC score	0.373312 (rank : 229)
Query Neighborhood Hits	534	Target Neighborhood Hits	1011	Shared Neighborhood Hits	345
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

HUNK_MOUSE
θ value	0.00175202 (rank : 51)	NC score	0.399747 (rank : 61)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KCC1A_HUMAN
θ value	0.00175202 (rank : 52)	NC score	0.403780 (rank : 38)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	0.00175202 (rank : 53)	NC score	0.403721 (rank : 40)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	344
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1D_HUMAN
θ value	0.00175202 (rank : 54)	NC score	0.403660 (rank : 42)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	343
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	0.00175202 (rank : 55)	NC score	0.403690 (rank : 41)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_MOUSE
θ value	0.00175202 (rank : 56)	NC score	0.402128 (rank : 50)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M3K8_MOUSE
θ value	0.00175202 (rank : 57)	NC score	0.371517 (rank : 244)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	338
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MOK_MOUSE
θ value	0.00175202 (rank : 58)	NC score	0.384236 (rank : 163)
Query Neighborhood Hits	534	Target Neighborhood Hits	796	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

NIM1_HUMAN
θ value	0.00175202 (rank : 59)	NC score	0.403588 (rank : 43)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SGK1_MOUSE
θ value	0.00175202 (rank : 60)	NC score	0.393272 (rank : 97)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

CDKL2_MOUSE
θ value	0.00228821 (rank : 61)	NC score	0.385687 (rank : 148)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	343
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

WDR5_HUMAN
θ value	0.00228821 (rank : 62)	NC score	0.232650 (rank : 686)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	148
SwissProt Accessions	P61964, Q91VA5, Q9NWX7, Q9UGP9	Gene names	WDR5, BIG3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein).

WDR5_MOUSE
θ value	0.00228821 (rank : 63)	NC score	0.232650 (rank : 687)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	148
SwissProt Accessions	P61965, Q91VA5, Q922C9, Q9NWX7, Q9UGP9	Gene names	Wdr5, Big, Big3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein) (WD repeat protein BIG-3).

2AAA_HUMAN
θ value	0.00298849 (rank : 64)	NC score	0.145149 (rank : 1025)
Query Neighborhood Hits	534	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

CDKL2_HUMAN
θ value	0.00298849 (rank : 65)	NC score	0.385010 (rank : 154)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

HUNK_HUMAN
θ value	0.00298849 (rank : 66)	NC score	0.399034 (rank : 66)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	345
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

MARK1_MOUSE
θ value	0.00298849 (rank : 67)	NC score	0.398199 (rank : 69)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	344
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	0.00298849 (rank : 68)	NC score	0.397698 (rank : 72)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	347
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

AKT1_HUMAN
θ value	0.00390308 (rank : 69)	NC score	0.392451 (rank : 101)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	342
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	0.00390308 (rank : 70)	NC score	0.392986 (rank : 99)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	342
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CDKL4_MOUSE
θ value	0.00390308 (rank : 71)	NC score	0.382296 (rank : 181)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KS6A5_HUMAN
θ value	0.00390308 (rank : 72)	NC score	0.399157 (rank : 64)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	344
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	0.00390308 (rank : 73)	NC score	0.397244 (rank : 73)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MARK1_HUMAN
θ value	0.00390308 (rank : 74)	NC score	0.397718 (rank : 71)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	344
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PHKG2_MOUSE
θ value	0.00390308 (rank : 75)	NC score	0.411735 (rank : 7)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PLRG1_HUMAN
θ value	0.00390308 (rank : 76)	NC score	0.245412 (rank : 648)
Query Neighborhood Hits	534	Target Neighborhood Hits	318	Shared Neighborhood Hits	143
SwissProt Accessions	O43660, Q8WUD8	Gene names	PLRG1
Domain Architecture
Description	Pleiotropic regulator 1.

CDKL3_HUMAN
θ value	0.00509761 (rank : 77)	NC score	0.387100 (rank : 134)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

KCC1G_HUMAN
θ value	0.00509761 (rank : 78)	NC score	0.401157 (rank : 55)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	343
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M3K15_HUMAN
θ value	0.00509761 (rank : 79)	NC score	0.370854 (rank : 250)
Query Neighborhood Hits	534	Target Neighborhood Hits	914	Shared Neighborhood Hits	342
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

2AAA_MOUSE
θ value	0.00665767 (rank : 80)	NC score	0.141140 (rank : 1037)
Query Neighborhood Hits	534	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

2AAB_MOUSE
θ value	0.00665767 (rank : 81)	NC score	0.129980 (rank : 1061)
Query Neighborhood Hits	534	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

CHK2_HUMAN
θ value	0.00665767 (rank : 82)	NC score	0.409535 (rank : 12)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	345
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

MARK3_MOUSE
θ value	0.00665767 (rank : 83)	NC score	0.396376 (rank : 84)
Query Neighborhood Hits	534	Target Neighborhood Hits	919	Shared Neighborhood Hits	346
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PIM1_MOUSE
θ value	0.00665767 (rank : 84)	NC score	0.410398 (rank : 11)
Query Neighborhood Hits	534	Target Neighborhood Hits	787	Shared Neighborhood Hits	336
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PINK1_MOUSE
θ value	0.00665767 (rank : 85)	NC score	0.363093 (rank : 327)
Query Neighborhood Hits	534	Target Neighborhood Hits	726	Shared Neighborhood Hits	326
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SGK2_MOUSE
θ value	0.00665767 (rank : 86)	NC score	0.393980 (rank : 93)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	344
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

STRN_HUMAN
θ value	0.00665767 (rank : 87)	NC score	0.231411 (rank : 696)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	143
SwissProt Accessions	O43815, Q9NP38	Gene names	STRN
Domain Architecture
Description	Striatin.

TAF5L_HUMAN
θ value	0.00665767 (rank : 88)	NC score	0.234985 (rank : 669)
Query Neighborhood Hits	534	Target Neighborhood Hits	330	Shared Neighborhood Hits	149
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

WDR24_MOUSE
θ value	0.00665767 (rank : 89)	NC score	0.215417 (rank : 778)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	131
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

2AAB_HUMAN
θ value	0.00869519 (rank : 90)	NC score	0.125770 (rank : 1068)
Query Neighborhood Hits	534	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

AKT2_HUMAN
θ value	0.00869519 (rank : 91)	NC score	0.392184 (rank : 102)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	344
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	0.00869519 (rank : 92)	NC score	0.392051 (rank : 104)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	344
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

APAF_MOUSE
θ value	0.00869519 (rank : 93)	NC score	0.241142 (rank : 654)
Query Neighborhood Hits	534	Target Neighborhood Hits	343	Shared Neighborhood Hits	147
SwissProt Accessions	O88879	Gene names	Apaf1
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

CDKL3_MOUSE
θ value	0.00869519 (rank : 94)	NC score	0.387806 (rank : 127)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

M4K3_HUMAN
θ value	0.00869519 (rank : 95)	NC score	0.362608 (rank : 336)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MAST1_HUMAN
θ value	0.00869519 (rank : 96)	NC score	0.391394 (rank : 109)
Query Neighborhood Hits	534	Target Neighborhood Hits	1146	Shared Neighborhood Hits	347
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.00869519 (rank : 97)	NC score	0.391721 (rank : 107)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	345
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

RBBP4_HUMAN
θ value	0.00869519 (rank : 98)	NC score	0.226586 (rank : 716)
Query Neighborhood Hits	534	Target Neighborhood Hits	291	Shared Neighborhood Hits	145
SwissProt Accessions	Q09028, P31149, Q53H02, Q96BV9	Gene names	RBBP4, RBAP48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

RBBP4_MOUSE
θ value	0.00869519 (rank : 99)	NC score	0.227021 (rank : 714)
Query Neighborhood Hits	534	Target Neighborhood Hits	289	Shared Neighborhood Hits	144
SwissProt Accessions	Q60972	Gene names	Rbbp4, Rbap48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

SGK2_HUMAN
θ value	0.00869519 (rank : 100)	NC score	0.394480 (rank : 89)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	344
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

K0999_HUMAN
θ value	0.0113563 (rank : 101)	NC score	0.400534 (rank : 60)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCB_MOUSE
θ value	0.0113563 (rank : 102)	NC score	0.392124 (rank : 103)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

WDR57_HUMAN
θ value	0.0113563 (rank : 103)	NC score	0.232102 (rank : 691)
Query Neighborhood Hits	534	Target Neighborhood Hits	322	Shared Neighborhood Hits	147
SwissProt Accessions	Q96DI7, O75938, O95320	Gene names	WDR57, PRP8BP, SFP38
Domain Architecture	No domain graphic available
Description	WD repeat protein 57 (Prp8-binding protein) (hPRP8BP) (U5 snRNP- specific 40 kDa protein) (38 kDa-splicing factor).

KAPCB_HUMAN
θ value	0.0148317 (rank : 104)	NC score	0.391724 (rank : 106)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

M4K5_MOUSE
θ value	0.0148317 (rank : 105)	NC score	0.361424 (rank : 351)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

PHKG1_MOUSE
θ value	0.0148317 (rank : 106)	NC score	0.412986 (rank : 6)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	344
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TAF5L_MOUSE
θ value	0.0148317 (rank : 107)	NC score	0.232584 (rank : 688)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	147
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

TSSK3_HUMAN
θ value	0.0148317 (rank : 108)	NC score	0.408820 (rank : 15)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	341
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MORG1_HUMAN
θ value	0.0193708 (rank : 109)	NC score	0.234144 (rank : 681)
Query Neighborhood Hits	534	Target Neighborhood Hits	280	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BRX9, Q53FT6	Gene names	MORG1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

STRN4_MOUSE
θ value	0.0193708 (rank : 110)	NC score	0.234840 (rank : 671)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	144
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

WDR57_MOUSE
θ value	0.0193708 (rank : 111)	NC score	0.230916 (rank : 698)
Query Neighborhood Hits	534	Target Neighborhood Hits	323	Shared Neighborhood Hits	147
SwissProt Accessions	Q6PE01, Q3TEJ3, Q9DCX3	Gene names	Wdr57
Domain Architecture	No domain graphic available
Description	WD repeat protein 57.

CDKL4_HUMAN
θ value	0.0252991 (rank : 112)	NC score	0.381856 (rank : 184)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	342
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

K0999_MOUSE
θ value	0.0252991 (rank : 113)	NC score	0.399722 (rank : 62)
Query Neighborhood Hits	534	Target Neighborhood Hits	931	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

LIS1_HUMAN
θ value	0.0252991 (rank : 114)	NC score	0.234426 (rank : 675)
Query Neighborhood Hits	534	Target Neighborhood Hits	333	Shared Neighborhood Hits	147
SwissProt Accessions	P43034, Q8WZ88, Q8WZ89	Gene names	PAFAH1B1, LIS1, MDCR, PAFAHA
Domain Architecture
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

LIS1_MOUSE
θ value	0.0252991 (rank : 115)	NC score	0.234401 (rank : 676)
Query Neighborhood Hits	534	Target Neighborhood Hits	336	Shared Neighborhood Hits	147
SwissProt Accessions	P63005, O35592, P43035, P81692, Q9R2A6	Gene names	Pafah1b1, Lis-1, Lis1, Pafaha
Domain Architecture	No domain graphic available
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

M3K8_HUMAN
θ value	0.0252991 (rank : 116)	NC score	0.364054 (rank : 313)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	338
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MARK2_MOUSE
θ value	0.0252991 (rank : 117)	NC score	0.397096 (rank : 74)
Query Neighborhood Hits	534	Target Neighborhood Hits	1018	Shared Neighborhood Hits	346
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MK07_HUMAN
θ value	0.0252991 (rank : 118)	NC score	0.373041 (rank : 232)
Query Neighborhood Hits	534	Target Neighborhood Hits	1087	Shared Neighborhood Hits	344
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	0.0252991 (rank : 119)	NC score	0.373509 (rank : 227)
Query Neighborhood Hits	534	Target Neighborhood Hits	1054	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

SGK3_MOUSE
θ value	0.0252991 (rank : 120)	NC score	0.387502 (rank : 128)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

U3IP2_MOUSE
θ value	0.0252991 (rank : 121)	NC score	0.228055 (rank : 709)
Query Neighborhood Hits	534	Target Neighborhood Hits	312	Shared Neighborhood Hits	143
SwissProt Accessions	Q91WM3, Q8CFB7	Gene names	Rnu3ip2, U3-55k
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

WDR33_HUMAN
θ value	0.0252991 (rank : 122)	NC score	0.207926 (rank : 828)
Query Neighborhood Hits	534	Target Neighborhood Hits	638	Shared Neighborhood Hits	152
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

AL2S7_HUMAN
θ value	0.0330416 (rank : 123)	NC score	0.369099 (rank : 268)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	342
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CD2L7_HUMAN
θ value	0.0330416 (rank : 124)	NC score	0.368015 (rank : 285)
Query Neighborhood Hits	534	Target Neighborhood Hits	1275	Shared Neighborhood Hits	351
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

ERN1_HUMAN
θ value	0.0330416 (rank : 125)	NC score	0.361690 (rank : 345)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	343
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MAST2_HUMAN
θ value	0.0330416 (rank : 126)	NC score	0.389369 (rank : 119)
Query Neighborhood Hits	534	Target Neighborhood Hits	1189	Shared Neighborhood Hits	347
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MYLK_MOUSE
θ value	0.0330416 (rank : 127)	NC score	0.347167 (rank : 441)
Query Neighborhood Hits	534	Target Neighborhood Hits	1489	Shared Neighborhood Hits	345
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PIM1_HUMAN
θ value	0.0330416 (rank : 128)	NC score	0.407716 (rank : 18)
Query Neighborhood Hits	534	Target Neighborhood Hits	797	Shared Neighborhood Hits	336
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

STRN4_HUMAN
θ value	0.0330416 (rank : 129)	NC score	0.233033 (rank : 685)
Query Neighborhood Hits	534	Target Neighborhood Hits	325	Shared Neighborhood Hits	144
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

WDR39_HUMAN
θ value	0.0330416 (rank : 130)	NC score	0.230230 (rank : 702)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	143
SwissProt Accessions	O76071	Gene names	WDR39, CIAO1
Domain Architecture
Description	WD repeat protein 39 (Ciao 1 protein).

ICK_MOUSE
θ value	0.0431538 (rank : 131)	NC score	0.373061 (rank : 231)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	343
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KCC2A_HUMAN
θ value	0.0431538 (rank : 132)	NC score	0.405030 (rank : 28)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	0.0431538 (rank : 133)	NC score	0.405353 (rank : 25)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	344
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

MAK_MOUSE
θ value	0.0431538 (rank : 134)	NC score	0.371251 (rank : 246)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	343
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAST2_MOUSE
θ value	0.0431538 (rank : 135)	NC score	0.389977 (rank : 116)
Query Neighborhood Hits	534	Target Neighborhood Hits	1110	Shared Neighborhood Hits	347
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MK01_HUMAN
θ value	0.0431538 (rank : 136)	NC score	0.368696 (rank : 276)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	0.0431538 (rank : 137)	NC score	0.368736 (rank : 275)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PASK_MOUSE
θ value	0.0431538 (rank : 138)	NC score	0.404961 (rank : 29)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	345
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PIM3_HUMAN
θ value	0.0431538 (rank : 139)	NC score	0.408414 (rank : 17)
Query Neighborhood Hits	534	Target Neighborhood Hits	789	Shared Neighborhood Hits	334
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	0.0431538 (rank : 140)	NC score	0.410526 (rank : 10)
Query Neighborhood Hits	534	Target Neighborhood Hits	783	Shared Neighborhood Hits	332
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

SGK3_HUMAN
θ value	0.0431538 (rank : 141)	NC score	0.388033 (rank : 125)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	344
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

WDR37_HUMAN
θ value	0.0431538 (rank : 142)	NC score	0.234535 (rank : 674)
Query Neighborhood Hits	534	Target Neighborhood Hits	303	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y2I8, Q5SW03, Q9NTJ6	Gene names	WDR37, KIAA0982
Domain Architecture
Description	WD repeat protein 37.

WDR37_MOUSE
θ value	0.0431538 (rank : 143)	NC score	0.234255 (rank : 678)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	144
SwissProt Accessions	Q8CBE3, Q80Y96, Q8CCL2	Gene names	Wdr37, Kiaa0982
Domain Architecture
Description	WD repeat protein 37.

BRSK1_HUMAN
θ value	0.0563607 (rank : 144)	NC score	0.399157 (rank : 65)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	344
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CSK22_HUMAN
θ value	0.0563607 (rank : 145)	NC score	0.398902 (rank : 67)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	337
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
θ value	0.0563607 (rank : 146)	NC score	0.398839 (rank : 68)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	337
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ICK_HUMAN
θ value	0.0563607 (rank : 147)	NC score	0.371836 (rank : 240)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

IRAK3_MOUSE
θ value	0.0563607 (rank : 148)	NC score	0.241304 (rank : 653)
Query Neighborhood Hits	534	Target Neighborhood Hits	628	Shared Neighborhood Hits	235
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KCC2D_HUMAN
θ value	0.0563607 (rank : 149)	NC score	0.404924 (rank : 31)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	344
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

MAST3_HUMAN
θ value	0.0563607 (rank : 150)	NC score	0.389201 (rank : 120)
Query Neighborhood Hits	534	Target Neighborhood Hits	1128	Shared Neighborhood Hits	345
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	0.0563607 (rank : 151)	NC score	0.382033 (rank : 182)
Query Neighborhood Hits	534	Target Neighborhood Hits	1804	Shared Neighborhood Hits	359
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MASTL_HUMAN
θ value	0.0563607 (rank : 152)	NC score	0.381002 (rank : 193)
Query Neighborhood Hits	534	Target Neighborhood Hits	894	Shared Neighborhood Hits	343
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	0.0563607 (rank : 153)	NC score	0.380036 (rank : 195)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	344
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MEP50_MOUSE
θ value	0.0563607 (rank : 154)	NC score	0.227584 (rank : 711)
Query Neighborhood Hits	534	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q99J09, Q3TFJ1, Q8BSH8, Q9CZY5	Gene names	Wdr77, Mep50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

MK03_HUMAN
θ value	0.0563607 (rank : 155)	NC score	0.363696 (rank : 317)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

RBBP7_HUMAN
θ value	0.0563607 (rank : 156)	NC score	0.218609 (rank : 754)
Query Neighborhood Hits	534	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

RBBP7_MOUSE
θ value	0.0563607 (rank : 157)	NC score	0.218451 (rank : 757)
Query Neighborhood Hits	534	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

STRN_MOUSE
θ value	0.0563607 (rank : 158)	NC score	0.225622 (rank : 719)
Query Neighborhood Hits	534	Target Neighborhood Hits	326	Shared Neighborhood Hits	145
SwissProt Accessions	O55106	Gene names	Strn
Domain Architecture
Description	Striatin.

TSSK3_MOUSE
θ value	0.0563607 (rank : 159)	NC score	0.408693 (rank : 16)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	341
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CDC20_HUMAN
θ value	0.0736092 (rank : 160)	NC score	0.216721 (rank : 771)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	142
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

CDK9_MOUSE
θ value	0.0736092 (rank : 161)	NC score	0.369085 (rank : 269)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	342
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

E2AK2_MOUSE
θ value	0.0736092 (rank : 162)	NC score	0.361708 (rank : 344)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	344
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

GAK_HUMAN
θ value	0.0736092 (rank : 163)	NC score	0.360972 (rank : 357)
Query Neighborhood Hits	534	Target Neighborhood Hits	1028	Shared Neighborhood Hits	342
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KCC4_MOUSE
θ value	0.0736092 (rank : 164)	NC score	0.403752 (rank : 39)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

LATS1_MOUSE
θ value	0.0736092 (rank : 165)	NC score	0.385961 (rank : 142)
Query Neighborhood Hits	534	Target Neighborhood Hits	1027	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

MARK4_HUMAN
θ value	0.0736092 (rank : 166)	NC score	0.394236 (rank : 90)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	346
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	0.0736092 (rank : 167)	NC score	0.394145 (rank : 91)
Query Neighborhood Hits	534	Target Neighborhood Hits	898	Shared Neighborhood Hits	344
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MKNK2_HUMAN
θ value	0.0736092 (rank : 168)	NC score	0.407524 (rank : 19)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	343
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MYLK_HUMAN
θ value	0.0736092 (rank : 169)	NC score	0.346819 (rank : 444)
Query Neighborhood Hits	534	Target Neighborhood Hits	1328	Shared Neighborhood Hits	343
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PLK4_HUMAN
θ value	0.0736092 (rank : 170)	NC score	0.386038 (rank : 141)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	344
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

IF32_HUMAN
θ value	0.0961366 (rank : 171)	NC score	0.213604 (rank : 793)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	124
SwissProt Accessions	Q13347	Gene names	EIF3S2, TRIP1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

IF32_MOUSE
θ value	0.0961366 (rank : 172)	NC score	0.214275 (rank : 786)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QZD9	Gene names	Eif3s2, Trip1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

KAPCA_HUMAN
θ value	0.0961366 (rank : 173)	NC score	0.390380 (rank : 113)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	0.0961366 (rank : 174)	NC score	0.389969 (rank : 117)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

M4K5_HUMAN
θ value	0.0961366 (rank : 175)	NC score	0.357988 (rank : 388)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MAK_HUMAN
θ value	0.0961366 (rank : 176)	NC score	0.370601 (rank : 253)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	342
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PAK7_HUMAN
θ value	0.0961366 (rank : 177)	NC score	0.368963 (rank : 274)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	0.0961366 (rank : 178)	NC score	0.369322 (rank : 266)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	345
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

SPEG_HUMAN
θ value	0.0961366 (rank : 179)	NC score	0.351690 (rank : 422)
Query Neighborhood Hits	534	Target Neighborhood Hits	1762	Shared Neighborhood Hits	349
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK16_HUMAN
θ value	0.0961366 (rank : 180)	NC score	0.361593 (rank : 348)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	344
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

TAOK3_MOUSE
θ value	0.0961366 (rank : 181)	NC score	0.327163 (rank : 530)
Query Neighborhood Hits	534	Target Neighborhood Hits	1458	Shared Neighborhood Hits	352
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TNIK_HUMAN
θ value	0.0961366 (rank : 182)	NC score	0.340670 (rank : 470)
Query Neighborhood Hits	534	Target Neighborhood Hits	1570	Shared Neighborhood Hits	352
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

CDK6_HUMAN
θ value	0.125558 (rank : 183)	NC score	0.361277 (rank : 354)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	0.125558 (rank : 184)	NC score	0.360941 (rank : 358)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CSK21_HUMAN
θ value	0.125558 (rank : 185)	NC score	0.396787 (rank : 75)
Query Neighborhood Hits	534	Target Neighborhood Hits	772	Shared Neighborhood Hits	336
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	0.125558 (rank : 186)	NC score	0.396230 (rank : 86)
Query Neighborhood Hits	534	Target Neighborhood Hits	770	Shared Neighborhood Hits	336
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

KPCI_HUMAN
θ value	0.125558 (rank : 187)	NC score	0.388827 (rank : 123)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	344
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	0.125558 (rank : 188)	NC score	0.389034 (rank : 122)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	344
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KS6A3_HUMAN
θ value	0.125558 (rank : 189)	NC score	0.379524 (rank : 198)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	344
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	0.125558 (rank : 190)	NC score	0.379473 (rank : 199)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	344
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PLK4_MOUSE
θ value	0.125558 (rank : 191)	NC score	0.385217 (rank : 153)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	346
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

RBBP5_HUMAN
θ value	0.125558 (rank : 192)	NC score	0.184840 (rank : 923)
Query Neighborhood Hits	534	Target Neighborhood Hits	372	Shared Neighborhood Hits	107
SwissProt Accessions	Q15291	Gene names	RBBP5, RBQ3
Domain Architecture
Description	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3).

SPG16_HUMAN
θ value	0.125558 (rank : 193)	NC score	0.230494 (rank : 700)
Query Neighborhood Hits	534	Target Neighborhood Hits	361	Shared Neighborhood Hits	146
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

WDR1_MOUSE
θ value	0.125558 (rank : 194)	NC score	0.227476 (rank : 712)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	O88342	Gene names	Wdr1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1).

AVR2B_HUMAN
θ value	0.163984 (rank : 195)	NC score	0.289917 (rank : 577)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	332
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	0.163984 (rank : 196)	NC score	0.290080 (rank : 576)
Query Neighborhood Hits	534	Target Neighborhood Hits	749	Shared Neighborhood Hits	332
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BRSK2_HUMAN
θ value	0.163984 (rank : 197)	NC score	0.398129 (rank : 70)
Query Neighborhood Hits	534	Target Neighborhood Hits	897	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CDK9_HUMAN
θ value	0.163984 (rank : 198)	NC score	0.368320 (rank : 281)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	342
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

DMPK_HUMAN
θ value	0.163984 (rank : 199)	NC score	0.388769 (rank : 124)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	344
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	0.163984 (rank : 200)	NC score	0.389196 (rank : 121)
Query Neighborhood Hits	534	Target Neighborhood Hits	908	Shared Neighborhood Hits	342
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ERN1_MOUSE
θ value	0.163984 (rank : 201)	NC score	0.354537 (rank : 408)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	342
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

GRWD1_MOUSE
θ value	0.163984 (rank : 202)	NC score	0.219338 (rank : 750)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q810D6, Q922H3	Gene names	Grwd1, A301
Domain Architecture	No domain graphic available
Description	Glutamate-rich WD repeat-containing protein 1 (Protein A301).

HIRA_HUMAN
θ value	0.163984 (rank : 203)	NC score	0.207420 (rank : 832)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	131
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

HIRA_MOUSE
θ value	0.163984 (rank : 204)	NC score	0.210359 (rank : 814)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	133
SwissProt Accessions	Q61666, O08845, Q62365	Gene names	Hira, Tuple1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

KCC2B_HUMAN
θ value	0.163984 (rank : 205)	NC score	0.405193 (rank : 26)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	344
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	0.163984 (rank : 206)	NC score	0.404946 (rank : 30)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	345
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2G_HUMAN
θ value	0.163984 (rank : 207)	NC score	0.400893 (rank : 58)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	0.163984 (rank : 208)	NC score	0.400870 (rank : 59)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KPCD3_MOUSE
θ value	0.163984 (rank : 209)	NC score	0.382920 (rank : 173)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCL_MOUSE
θ value	0.163984 (rank : 210)	NC score	0.382794 (rank : 174)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	343
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6A6_HUMAN
θ value	0.163984 (rank : 211)	NC score	0.382324 (rank : 179)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

M3K2_HUMAN
θ value	0.163984 (rank : 212)	NC score	0.367752 (rank : 288)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MK03_MOUSE
θ value	0.163984 (rank : 213)	NC score	0.363493 (rank : 320)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

PIM2_HUMAN
θ value	0.163984 (rank : 214)	NC score	0.403927 (rank : 36)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	341
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	0.163984 (rank : 215)	NC score	0.404246 (rank : 33)
Query Neighborhood Hits	534	Target Neighborhood Hits	809	Shared Neighborhood Hits	338
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PRP4_HUMAN
θ value	0.163984 (rank : 216)	NC score	0.223430 (rank : 732)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	144
SwissProt Accessions	O43172, O43445, O43864, Q96DG2, Q96IK4	Gene names	PRPF4, PRP4
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) (hPrp4).

PRP4_MOUSE
θ value	0.163984 (rank : 217)	NC score	0.223574 (rank : 731)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DAW6	Gene names	Prpf4
Domain Architecture	No domain graphic available
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4).

SPEG_MOUSE
θ value	0.163984 (rank : 218)	NC score	0.349937 (rank : 433)
Query Neighborhood Hits	534	Target Neighborhood Hits	1959	Shared Neighborhood Hits	351
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

UHMK1_HUMAN
θ value	0.163984 (rank : 219)	NC score	0.350044 (rank : 430)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	328
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

WDR1_HUMAN
θ value	0.163984 (rank : 220)	NC score	0.226863 (rank : 715)
Query Neighborhood Hits	534	Target Neighborhood Hits	292	Shared Neighborhood Hits	143
SwissProt Accessions	O75083, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0	Gene names	WDR1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1).

AURKC_HUMAN
θ value	0.21417 (rank : 221)	NC score	0.383837 (rank : 164)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	345
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

CDK3_HUMAN
θ value	0.21417 (rank : 222)	NC score	0.368217 (rank : 282)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

GAK_MOUSE
θ value	0.21417 (rank : 223)	NC score	0.364650 (rank : 312)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	342
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCD3_HUMAN
θ value	0.21417 (rank : 224)	NC score	0.381677 (rank : 186)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	342
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KS6A2_HUMAN
θ value	0.21417 (rank : 225)	NC score	0.379282 (rank : 201)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6B2_HUMAN
θ value	0.21417 (rank : 226)	NC score	0.391495 (rank : 108)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

M3K3_HUMAN
θ value	0.21417 (rank : 227)	NC score	0.363546 (rank : 318)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	343
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MK04_HUMAN
θ value	0.21417 (rank : 228)	NC score	0.373386 (rank : 228)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	342
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK09_MOUSE
θ value	0.21417 (rank : 229)	NC score	0.375500 (rank : 218)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK15_HUMAN
θ value	0.21417 (rank : 230)	NC score	0.375806 (rank : 217)
Query Neighborhood Hits	534	Target Neighborhood Hits	1038	Shared Neighborhood Hits	348
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MORG1_MOUSE
θ value	0.21417 (rank : 231)	NC score	0.228288 (rank : 708)
Query Neighborhood Hits	534	Target Neighborhood Hits	281	Shared Neighborhood Hits	139
SwissProt Accessions	Q9DAJ4, Q505C2, Q8VEB7, Q99JX9, Q9D235	Gene names	Morg1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

NEK4_MOUSE
θ value	0.21417 (rank : 232)	NC score	0.361787 (rank : 343)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_MOUSE
θ value	0.21417 (rank : 233)	NC score	0.353044 (rank : 415)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PPWD1_MOUSE
θ value	0.21417 (rank : 234)	NC score	0.089082 (rank : 1120)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CEC6	Gene names	Ppwd1
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

PRP19_MOUSE
θ value	0.21417 (rank : 235)	NC score	0.224746 (rank : 724)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	146
SwissProt Accessions	Q99KP6, Q3TP64, Q8BKZ5, Q8BVQ4	Gene names	Prpf19, Prp19, Snev
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (Nuclear matrix protein SNEV).

ROCK2_MOUSE
θ value	0.21417 (rank : 236)	NC score	0.339023 (rank : 476)
Query Neighborhood Hits	534	Target Neighborhood Hits	2072	Shared Neighborhood Hits	351
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

STRN3_HUMAN
θ value	0.21417 (rank : 237)	NC score	0.220740 (rank : 745)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	144
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

UHMK1_MOUSE
θ value	0.21417 (rank : 238)	NC score	0.349023 (rank : 436)
Query Neighborhood Hits	534	Target Neighborhood Hits	809	Shared Neighborhood Hits	328
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

WDR76_HUMAN
θ value	0.21417 (rank : 239)	NC score	0.114480 (rank : 1087)
Query Neighborhood Hits	534	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H967	Gene names	WDR76
Domain Architecture	No domain graphic available
Description	WD repeat protein 76.

AHI1_MOUSE
θ value	0.279714 (rank : 240)	NC score	0.158080 (rank : 988)
Query Neighborhood Hits	534	Target Neighborhood Hits	496	Shared Neighborhood Hits	137
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ERCC8_HUMAN
θ value	0.279714 (rank : 241)	NC score	0.217435 (rank : 763)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	143
SwissProt Accessions	Q13216, Q6FHX5, Q96GB9	Gene names	ERCC8, CKN1, CSA
Domain Architecture
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA).

KCC4_HUMAN
θ value	0.279714 (rank : 242)	NC score	0.401067 (rank : 56)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP2_HUMAN
θ value	0.279714 (rank : 243)	NC score	0.378517 (rank : 208)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	345
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KPCD1_MOUSE
θ value	0.279714 (rank : 244)	NC score	0.383599 (rank : 167)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	343
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCL_HUMAN
θ value	0.279714 (rank : 245)	NC score	0.382314 (rank : 180)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	343
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6A1_HUMAN
θ value	0.279714 (rank : 246)	NC score	0.378521 (rank : 207)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KSR2_HUMAN
θ value	0.279714 (rank : 247)	NC score	0.308143 (rank : 548)
Query Neighborhood Hits	534	Target Neighborhood Hits	920	Shared Neighborhood Hits	342
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LATS1_HUMAN
θ value	0.279714 (rank : 248)	NC score	0.383473 (rank : 170)
Query Neighborhood Hits	534	Target Neighborhood Hits	1057	Shared Neighborhood Hits	345
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MKNK1_MOUSE
θ value	0.279714 (rank : 249)	NC score	0.401902 (rank : 51)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	341
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_MOUSE
θ value	0.279714 (rank : 250)	NC score	0.403868 (rank : 37)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	343
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PP4R1_MOUSE
θ value	0.279714 (rank : 251)	NC score	0.081974 (rank : 1129)
Query Neighborhood Hits	534	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

PRKX_HUMAN
θ value	0.279714 (rank : 252)	NC score	0.386112 (rank : 139)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	344
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

ROCK2_HUMAN
θ value	0.279714 (rank : 253)	NC score	0.341307 (rank : 466)
Query Neighborhood Hits	534	Target Neighborhood Hits	2073	Shared Neighborhood Hits	353
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

STRN3_MOUSE
θ value	0.279714 (rank : 254)	NC score	0.218606 (rank : 755)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	142
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

SYG_MOUSE
θ value	0.279714 (rank : 255)	NC score	0.036154 (rank : 1173)
Query Neighborhood Hits	534	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZD3, Q8VC67	Gene names	Gars
Domain Architecture
Description	Glycyl-tRNA synthetase (EC 6.1.1.14) (Glycine--tRNA ligase) (GlyRS).

TEP1_MOUSE
θ value	0.279714 (rank : 256)	NC score	0.203395 (rank : 857)
Query Neighborhood Hits	534	Target Neighborhood Hits	344	Shared Neighborhood Hits	146
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

AURKC_MOUSE
θ value	0.365318 (rank : 257)	NC score	0.383084 (rank : 172)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

CDK4_HUMAN
θ value	0.365318 (rank : 258)	NC score	0.359894 (rank : 365)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	0.365318 (rank : 259)	NC score	0.359533 (rank : 372)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

GRWD1_HUMAN
θ value	0.365318 (rank : 260)	NC score	0.214458 (rank : 784)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	144
SwissProt Accessions	Q9BQ67	Gene names	GRWD1, GRWD, WDR28
Domain Architecture
Description	Glutamate-rich WD repeat-containing protein 1.

KPCZ_HUMAN
θ value	0.365318 (rank : 261)	NC score	0.386125 (rank : 138)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	343
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	0.365318 (rank : 262)	NC score	0.386219 (rank : 137)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	343
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KS6A1_MOUSE
θ value	0.365318 (rank : 263)	NC score	0.383650 (rank : 165)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_MOUSE
θ value	0.365318 (rank : 264)	NC score	0.379361 (rank : 200)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KSR1_HUMAN
θ value	0.365318 (rank : 265)	NC score	0.289168 (rank : 578)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	339
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	0.365318 (rank : 266)	NC score	0.294985 (rank : 563)
Query Neighborhood Hits	534	Target Neighborhood Hits	870	Shared Neighborhood Hits	342
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

M3K3_MOUSE
θ value	0.365318 (rank : 267)	NC score	0.362857 (rank : 331)
Query Neighborhood Hits	534	Target Neighborhood Hits	876	Shared Neighborhood Hits	343
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MK06_HUMAN
θ value	0.365318 (rank : 268)	NC score	0.368573 (rank : 280)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	338
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	0.365318 (rank : 269)	NC score	0.367978 (rank : 286)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	338
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK09_HUMAN
θ value	0.365318 (rank : 270)	NC score	0.377929 (rank : 212)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	346
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

PP4R1_HUMAN
θ value	0.365318 (rank : 271)	NC score	0.079740 (rank : 1131)
Query Neighborhood Hits	534	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TF05, Q99774, Q9UNQ7	Gene names	PPP4R1, MEG1, PP4R1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

PPWD1_HUMAN
θ value	0.365318 (rank : 272)	NC score	0.086826 (rank : 1123)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q96BP3, Q15002, Q7KZ89	Gene names	PPWD1, KIAA0073
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

PRKX_MOUSE
θ value	0.365318 (rank : 273)	NC score	0.386441 (rank : 136)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

SPG16_MOUSE
θ value	0.365318 (rank : 274)	NC score	0.230579 (rank : 699)
Query Neighborhood Hits	534	Target Neighborhood Hits	377	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

ST38L_HUMAN
θ value	0.365318 (rank : 275)	NC score	0.387231 (rank : 132)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	339
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK33_HUMAN
θ value	0.365318 (rank : 276)	NC score	0.385390 (rank : 151)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	344
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK38_HUMAN
θ value	0.365318 (rank : 277)	NC score	0.385934 (rank : 143)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	0.365318 (rank : 278)	NC score	0.385844 (rank : 145)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TEP1_HUMAN
θ value	0.365318 (rank : 279)	NC score	0.211411 (rank : 809)
Query Neighborhood Hits	534	Target Neighborhood Hits	371	Shared Neighborhood Hits	148
SwissProt Accessions	Q99973	Gene names	TEP1, TLP1, TP1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog).

U3IP2_HUMAN
θ value	0.365318 (rank : 280)	NC score	0.218285 (rank : 760)
Query Neighborhood Hits	534	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

BRWD1_HUMAN
θ value	0.47712 (rank : 281)	NC score	0.193116 (rank : 898)
Query Neighborhood Hits	534	Target Neighborhood Hits	448	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

CDC20_MOUSE
θ value	0.47712 (rank : 282)	NC score	0.213757 (rank : 791)
Query Neighborhood Hits	534	Target Neighborhood Hits	325	Shared Neighborhood Hits	145
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

CHK1_HUMAN
θ value	0.47712 (rank : 283)	NC score	0.392540 (rank : 100)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	0.47712 (rank : 284)	NC score	0.393511 (rank : 95)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

E2AK3_MOUSE
θ value	0.47712 (rank : 285)	NC score	0.351880 (rank : 421)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

FBW1B_HUMAN
θ value	0.47712 (rank : 286)	NC score	0.216188 (rank : 774)
Query Neighborhood Hits	534	Target Neighborhood Hits	327	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

FBXW5_MOUSE
θ value	0.47712 (rank : 287)	NC score	0.153978 (rank : 1000)
Query Neighborhood Hits	534	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QXW2	Gene names	Fbxw5, Fbw5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

KPCG_HUMAN
θ value	0.47712 (rank : 288)	NC score	0.363182 (rank : 324)
Query Neighborhood Hits	534	Target Neighborhood Hits	1126	Shared Neighborhood Hits	341
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6B2_MOUSE
θ value	0.47712 (rank : 289)	NC score	0.390523 (rank : 111)
Query Neighborhood Hits	534	Target Neighborhood Hits	871	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KTNB1_HUMAN
θ value	0.47712 (rank : 290)	NC score	0.224395 (rank : 726)
Query Neighborhood Hits	534	Target Neighborhood Hits	349	Shared Neighborhood Hits	151
SwissProt Accessions	Q9BVA0, O60620	Gene names	KATNB1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

KTNB1_MOUSE
θ value	0.47712 (rank : 291)	NC score	0.224428 (rank : 725)
Query Neighborhood Hits	534	Target Neighborhood Hits	356	Shared Neighborhood Hits	152
SwissProt Accessions	Q8BG40, Q8CD18, Q8R1J0, Q9CWV2	Gene names	Katnb1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

LATS2_HUMAN
θ value	0.47712 (rank : 292)	NC score	0.382487 (rank : 178)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	341
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	0.47712 (rank : 293)	NC score	0.383087 (rank : 171)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	341
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

NLK_HUMAN
θ value	0.47712 (rank : 294)	NC score	0.368645 (rank : 278)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	0.47712 (rank : 295)	NC score	0.368650 (rank : 277)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	343
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

PCTK2_HUMAN
θ value	0.47712 (rank : 296)	NC score	0.363726 (rank : 316)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	0.47712 (rank : 297)	NC score	0.363087 (rank : 328)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PINK1_HUMAN
θ value	0.47712 (rank : 298)	NC score	0.356073 (rank : 396)
Query Neighborhood Hits	534	Target Neighborhood Hits	741	Shared Neighborhood Hits	328
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RIPK5_MOUSE
θ value	0.47712 (rank : 299)	NC score	0.329023 (rank : 519)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ST38L_MOUSE
θ value	0.47712 (rank : 300)	NC score	0.387327 (rank : 130)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	336
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STB5L_HUMAN
θ value	0.47712 (rank : 301)	NC score	0.069059 (rank : 1151)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2K9, Q4G1B4, Q6PIC3	Gene names	STXBP5L, KIAA1006, LLGL4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

STB5L_MOUSE
θ value	0.47712 (rank : 302)	NC score	0.069046 (rank : 1152)
Query Neighborhood Hits	534	Target Neighborhood Hits	138	Shared Neighborhood Hits	66
SwissProt Accessions	Q5DQR4, Q3TSM3, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52	Gene names	Stxbp5l, Llgl4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

UTP15_HUMAN
θ value	0.47712 (rank : 303)	NC score	0.216832 (rank : 768)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q8TED0, Q6IA60, Q96E08, Q9H9F8	Gene names	UTP15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog.

CDK5_HUMAN
θ value	0.62314 (rank : 304)	NC score	0.365000 (rank : 308)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	341
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	0.62314 (rank : 305)	NC score	0.364986 (rank : 309)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	341
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CTRO_MOUSE
θ value	0.62314 (rank : 306)	NC score	0.326733 (rank : 532)
Query Neighborhood Hits	534	Target Neighborhood Hits	2344	Shared Neighborhood Hits	354
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

E2AK4_MOUSE
θ value	0.62314 (rank : 307)	NC score	0.357842 (rank : 389)
Query Neighborhood Hits	534	Target Neighborhood Hits	984	Shared Neighborhood Hits	342
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

IRAK3_HUMAN
θ value	0.62314 (rank : 308)	NC score	0.241742 (rank : 652)
Query Neighborhood Hits	534	Target Neighborhood Hits	644	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KAPCG_HUMAN
θ value	0.62314 (rank : 309)	NC score	0.385525 (rank : 150)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	343
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KPCD2_HUMAN
θ value	0.62314 (rank : 310)	NC score	0.381704 (rank : 185)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	343
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

M3K6_HUMAN
θ value	0.62314 (rank : 311)	NC score	0.368969 (rank : 273)
Query Neighborhood Hits	534	Target Neighborhood Hits	889	Shared Neighborhood Hits	342
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

MK04_MOUSE
θ value	0.62314 (rank : 312)	NC score	0.371685 (rank : 243)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	342
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

NEK3_HUMAN
θ value	0.62314 (rank : 313)	NC score	0.363096 (rank : 326)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	344
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK7_MOUSE
θ value	0.62314 (rank : 314)	NC score	0.352269 (rank : 418)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NRK_MOUSE
θ value	0.62314 (rank : 315)	NC score	0.342573 (rank : 459)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	343
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PFTK1_HUMAN
θ value	0.62314 (rank : 316)	NC score	0.369014 (rank : 271)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	343
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	0.62314 (rank : 317)	NC score	0.369104 (rank : 267)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	344
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PRP19_HUMAN
θ value	0.62314 (rank : 318)	NC score	0.222967 (rank : 734)
Query Neighborhood Hits	534	Target Neighborhood Hits	333	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UMS4	Gene names	PRPF19, NMP200, PRP19
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (hPso4).

RIPK1_HUMAN
θ value	0.62314 (rank : 319)	NC score	0.303787 (rank : 553)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	344
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK5_HUMAN
θ value	0.62314 (rank : 320)	NC score	0.328979 (rank : 520)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	344
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

SNRK_HUMAN
θ value	0.62314 (rank : 321)	NC score	0.401624 (rank : 53)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	343
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SOX12_MOUSE
θ value	0.62314 (rank : 322)	NC score	0.020392 (rank : 1181)
Query Neighborhood Hits	534	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

TBL2_MOUSE
θ value	0.62314 (rank : 323)	NC score	0.207573 (rank : 830)
Query Neighborhood Hits	534	Target Neighborhood Hits	221	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

TSSK1_HUMAN
θ value	0.62314 (rank : 324)	NC score	0.396605 (rank : 78)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CD2L1_MOUSE
θ value	0.813845 (rank : 325)	NC score	0.354448 (rank : 409)
Query Neighborhood Hits	534	Target Neighborhood Hits	1463	Shared Neighborhood Hits	349
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

COPB2_HUMAN
θ value	0.813845 (rank : 326)	NC score	0.216857 (rank : 767)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	145
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

COPB2_MOUSE
θ value	0.813845 (rank : 327)	NC score	0.216831 (rank : 769)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	145
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

CSTF1_HUMAN
θ value	0.813845 (rank : 328)	NC score	0.211265 (rank : 810)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	134
SwissProt Accessions	Q05048	Gene names	CSTF1
Domain Architecture
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

CTRO_HUMAN
θ value	0.813845 (rank : 329)	NC score	0.336297 (rank : 480)
Query Neighborhood Hits	534	Target Neighborhood Hits	2092	Shared Neighborhood Hits	352
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

KPCD1_HUMAN
θ value	0.813845 (rank : 330)	NC score	0.381632 (rank : 187)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	343
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCG_MOUSE
θ value	0.813845 (rank : 331)	NC score	0.362720 (rank : 333)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	341
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPSH1_HUMAN
θ value	0.813845 (rank : 332)	NC score	0.396630 (rank : 77)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	0.813845 (rank : 333)	NC score	0.396455 (rank : 82)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

M4K4_HUMAN
θ value	0.813845 (rank : 334)	NC score	0.335129 (rank : 490)
Query Neighborhood Hits	534	Target Neighborhood Hits	1589	Shared Neighborhood Hits	350
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	0.813845 (rank : 335)	NC score	0.328464 (rank : 522)
Query Neighborhood Hits	534	Target Neighborhood Hits	1560	Shared Neighborhood Hits	349
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MK11_MOUSE
θ value	0.813845 (rank : 336)	NC score	0.366826 (rank : 294)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	343
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

NEK3_MOUSE
θ value	0.813845 (rank : 337)	NC score	0.366869 (rank : 293)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PAK4_HUMAN
θ value	0.813845 (rank : 338)	NC score	0.368054 (rank : 284)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	344
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PEX7_HUMAN
θ value	0.813845 (rank : 339)	NC score	0.216326 (rank : 772)
Query Neighborhood Hits	534	Target Neighborhood Hits	275	Shared Neighborhood Hits	143
SwissProt Accessions	O00628	Gene names	PEX7, PTS2R
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

SMU1_HUMAN
θ value	0.813845 (rank : 340)	NC score	0.217071 (rank : 765)
Query Neighborhood Hits	534	Target Neighborhood Hits	311	Shared Neighborhood Hits	147
SwissProt Accessions	Q2TAY7, Q9BU59, Q9HA96, Q9NVD1	Gene names	SMU1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

SMU1_MOUSE
θ value	0.813845 (rank : 341)	NC score	0.217071 (rank : 766)
Query Neighborhood Hits	534	Target Neighborhood Hits	311	Shared Neighborhood Hits	147
SwissProt Accessions	Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70	Gene names	Smu1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

SNRK_MOUSE
θ value	0.813845 (rank : 342)	NC score	0.401834 (rank : 52)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

TSSK4_HUMAN
θ value	0.813845 (rank : 343)	NC score	0.385236 (rank : 152)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	344
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

WDR16_MOUSE
θ value	0.813845 (rank : 344)	NC score	0.202805 (rank : 859)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	134
SwissProt Accessions	Q5F201, Q5F200, Q9D432, Q9DA68	Gene names	WDR16
Domain Architecture	No domain graphic available
Description	WD repeat protein 16.

WDR48_HUMAN
θ value	0.813845 (rank : 345)	NC score	0.214257 (rank : 787)
Query Neighborhood Hits	534	Target Neighborhood Hits	291	Shared Neighborhood Hits	144
SwissProt Accessions	Q8TAF3, Q63HJ2, Q658Y1, Q8N3Z1, Q9NSK8, Q9P279	Gene names	WDR48, KIAA1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48 (WD repeat endosomal protein) (p80).

BRWD1_MOUSE
θ value	1.06291 (rank : 346)	NC score	0.190391 (rank : 904)
Query Neighborhood Hits	534	Target Neighborhood Hits	478	Shared Neighborhood Hits	149
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

DAPK3_MOUSE
θ value	1.06291 (rank : 347)	NC score	0.382582 (rank : 177)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	342
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ERN2_HUMAN
θ value	1.06291 (rank : 348)	NC score	0.357146 (rank : 394)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FAN_HUMAN
θ value	1.06291 (rank : 349)	NC score	0.171604 (rank : 969)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	140
SwissProt Accessions	Q92636	Gene names	NSMAF, FAN
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

FAN_MOUSE
θ value	1.06291 (rank : 350)	NC score	0.169009 (rank : 974)
Query Neighborhood Hits	534	Target Neighborhood Hits	292	Shared Neighborhood Hits	138
SwissProt Accessions	O35242	Gene names	Nsmaf, Fan
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

HIPK1_HUMAN
θ value	1.06291 (rank : 351)	NC score	0.348935 (rank : 437)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	333
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	1.06291 (rank : 352)	NC score	0.348886 (rank : 438)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	333
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

KPCE_HUMAN
θ value	1.06291 (rank : 353)	NC score	0.378701 (rank : 205)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	343
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

OBSCN_HUMAN
θ value	1.06291 (rank : 354)	NC score	0.335909 (rank : 483)
Query Neighborhood Hits	534	Target Neighborhood Hits	1931	Shared Neighborhood Hits	348
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PEX7_MOUSE
θ value	1.06291 (rank : 355)	NC score	0.215763 (rank : 776)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	143
SwissProt Accessions	P97865	Gene names	Pex7
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

PTN23_HUMAN
θ value	1.06291 (rank : 356)	NC score	0.013062 (rank : 1190)
Query Neighborhood Hits	534	Target Neighborhood Hits	646	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

SYMPK_HUMAN
θ value	1.06291 (rank : 357)	NC score	0.038596 (rank : 1171)
Query Neighborhood Hits	534	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

TAF5_MOUSE
θ value	1.06291 (rank : 358)	NC score	0.217500 (rank : 762)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	145
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

TSSK1_MOUSE
θ value	1.06291 (rank : 359)	NC score	0.390567 (rank : 110)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	344
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

WDR16_HUMAN
θ value	1.06291 (rank : 360)	NC score	0.198770 (rank : 880)
Query Neighborhood Hits	534	Target Neighborhood Hits	275	Shared Neighborhood Hits	132
SwissProt Accessions	Q8N1V2, Q5DX23, Q8TC73, Q8TCI3	Gene names	WDR16, WDRPUH
Domain Architecture	No domain graphic available
Description	WD repeat protein 16 (WD40-repeat protein up-regulated in HCC).

WDR48_MOUSE
θ value	1.06291 (rank : 361)	NC score	0.213818 (rank : 790)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BH57, Q80TD4, Q80XI0, Q8BRM0, Q8CBK0, Q922Z9, Q9CRR1, Q9CSL0	Gene names	Wdr48, Kiaa1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48.

AURKB_MOUSE
θ value	1.38821 (rank : 362)	NC score	0.384882 (rank : 157)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

CD2L1_HUMAN
θ value	1.38821 (rank : 363)	NC score	0.352389 (rank : 417)
Query Neighborhood Hits	534	Target Neighborhood Hits	1467	Shared Neighborhood Hits	348
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L2_HUMAN
θ value	1.38821 (rank : 364)	NC score	0.354233 (rank : 410)
Query Neighborhood Hits	534	Target Neighborhood Hits	1439	Shared Neighborhood Hits	348
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CSTF1_MOUSE
θ value	1.38821 (rank : 365)	NC score	0.212533 (rank : 801)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	137
SwissProt Accessions	Q99LC2, Q3UMB8, Q8BJW1, Q9CSU8	Gene names	Cstf1
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

FBXW4_MOUSE
θ value	1.38821 (rank : 366)	NC score	0.165780 (rank : 982)
Query Neighborhood Hits	534	Target Neighborhood Hits	205	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JMJ2, Q9QXW3	Gene names	Fbxw4, Fbw4
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Hagoromo protein).

FBXW5_HUMAN
θ value	1.38821 (rank : 367)	NC score	0.137881 (rank : 1046)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	98
SwissProt Accessions	Q969U6, Q5SPZ8, Q5SPZ9, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3	Gene names	FBXW5, FBW5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

FOXP1_MOUSE
θ value	1.38821 (rank : 368)	NC score	0.014432 (rank : 1189)
Query Neighborhood Hits	534	Target Neighborhood Hits	241	Shared Neighborhood Hits	9
SwissProt Accessions	P58462	Gene names	Foxp1
Domain Architecture
Description	Forkhead box protein P1 (Forkhead-related transcription factor 1).

KS6B1_HUMAN
θ value	1.38821 (rank : 369)	NC score	0.384932 (rank : 155)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	1.38821 (rank : 370)	NC score	0.384896 (rank : 156)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

OXSR1_HUMAN
θ value	1.38821 (rank : 371)	NC score	0.347120 (rank : 442)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	345
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	1.38821 (rank : 372)	NC score	0.346842 (rank : 443)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK4_MOUSE
θ value	1.38821 (rank : 373)	NC score	0.366883 (rank : 292)
Query Neighborhood Hits	534	Target Neighborhood Hits	1098	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

RHPN1_HUMAN
θ value	1.38821 (rank : 374)	NC score	0.029327 (rank : 1175)
Query Neighborhood Hits	534	Target Neighborhood Hits	158	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

STK36_HUMAN
θ value	1.38821 (rank : 375)	NC score	0.374111 (rank : 224)
Query Neighborhood Hits	534	Target Neighborhood Hits	896	Shared Neighborhood Hits	349
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	1.38821 (rank : 376)	NC score	0.372028 (rank : 239)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	344
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	1.38821 (rank : 377)	NC score	0.346554 (rank : 447)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	1.38821 (rank : 378)	NC score	0.346689 (rank : 445)
Query Neighborhood Hits	534	Target Neighborhood Hits	915	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

SYMPK_MOUSE
θ value	1.38821 (rank : 379)	NC score	0.037693 (rank : 1172)
Query Neighborhood Hits	534	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

TAF5_HUMAN
θ value	1.38821 (rank : 380)	NC score	0.216809 (rank : 770)
Query Neighborhood Hits	534	Target Neighborhood Hits	352	Shared Neighborhood Hits	145
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

TGFR1_HUMAN
θ value	1.38821 (rank : 381)	NC score	0.250342 (rank : 634)
Query Neighborhood Hits	534	Target Neighborhood Hits	755	Shared Neighborhood Hits	326
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	1.38821 (rank : 382)	NC score	0.250069 (rank : 636)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	326
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_MOUSE
θ value	1.38821 (rank : 383)	NC score	0.274802 (rank : 600)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	319
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

THOC3_HUMAN
θ value	1.38821 (rank : 384)	NC score	0.212491 (rank : 802)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	142
SwissProt Accessions	Q96J01	Gene names	THOC3
Domain Architecture
Description	THO complex subunit 3 (Tho3) (TEX1 homolog).

THOC3_MOUSE
θ value	1.38821 (rank : 385)	NC score	0.213152 (rank : 796)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VE80, Q9CWI8	Gene names	Thoc3
Domain Architecture
Description	THO complex subunit 3 (Tho3).

TITIN_HUMAN
θ value	1.38821 (rank : 386)	NC score	0.295788 (rank : 562)
Query Neighborhood Hits	534	Target Neighborhood Hits	2923	Shared Neighborhood Hits	350
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TLE2_HUMAN
θ value	1.38821 (rank : 387)	NC score	0.146882 (rank : 1020)
Query Neighborhood Hits	534	Target Neighborhood Hits	321	Shared Neighborhood Hits	139
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

VPS11_HUMAN
θ value	1.38821 (rank : 388)	NC score	0.040853 (rank : 1170)
Query Neighborhood Hits	534	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

VPS11_MOUSE
θ value	1.38821 (rank : 389)	NC score	0.041157 (rank : 1169)
Query Neighborhood Hits	534	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

WDR79_MOUSE
θ value	1.38821 (rank : 390)	NC score	0.179933 (rank : 940)
Query Neighborhood Hits	534	Target Neighborhood Hits	216	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VC51	Gene names	Wdr79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

ANR18_HUMAN
θ value	1.81305 (rank : 391)	NC score	0.002788 (rank : 1202)
Query Neighborhood Hits	534	Target Neighborhood Hits	1106	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

FBXW7_MOUSE
θ value	1.81305 (rank : 392)	NC score	0.207638 (rank : 829)
Query Neighborhood Hits	534	Target Neighborhood Hits	365	Shared Neighborhood Hits	147
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

KPCE_MOUSE
θ value	1.81305 (rank : 393)	NC score	0.378004 (rank : 211)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	343
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PRKY_HUMAN
θ value	1.81305 (rank : 394)	NC score	0.382699 (rank : 176)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

ROCK1_HUMAN
θ value	1.81305 (rank : 395)	NC score	0.335854 (rank : 484)
Query Neighborhood Hits	534	Target Neighborhood Hits	2000	Shared Neighborhood Hits	347
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.81305 (rank : 396)	NC score	0.329189 (rank : 518)
Query Neighborhood Hits	534	Target Neighborhood Hits	2126	Shared Neighborhood Hits	350
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TBL2_HUMAN
θ value	1.81305 (rank : 397)	NC score	0.204688 (rank : 851)
Query Neighborhood Hits	534	Target Neighborhood Hits	225	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

TGFR2_HUMAN
θ value	1.81305 (rank : 398)	NC score	0.273385 (rank : 601)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	318
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TLE4_HUMAN
θ value	1.81305 (rank : 399)	NC score	0.145657 (rank : 1023)
Query Neighborhood Hits	534	Target Neighborhood Hits	477	Shared Neighborhood Hits	140
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

TLE4_MOUSE
θ value	1.81305 (rank : 400)	NC score	0.145586 (rank : 1024)
Query Neighborhood Hits	534	Target Neighborhood Hits	482	Shared Neighborhood Hits	140
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

WDR61_MOUSE
θ value	1.81305 (rank : 401)	NC score	0.212281 (rank : 804)
Query Neighborhood Hits	534	Target Neighborhood Hits	331	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERF3, Q3U562, Q9CZP1	Gene names	Wdr61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

WSB1_HUMAN
θ value	1.81305 (rank : 402)	NC score	0.201845 (rank : 864)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

ZAN_HUMAN
θ value	1.81305 (rank : 403)	NC score	0.009814 (rank : 1195)
Query Neighborhood Hits	534	Target Neighborhood Hits	679	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

CDK10_HUMAN
θ value	2.36792 (rank : 404)	NC score	0.362640 (rank : 335)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	344
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

DAPK2_HUMAN
θ value	2.36792 (rank : 405)	NC score	0.381927 (rank : 183)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	2.36792 (rank : 406)	NC score	0.381008 (rank : 192)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

E2AK3_HUMAN
θ value	2.36792 (rank : 407)	NC score	0.349494 (rank : 435)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	344
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

F5006_HUMAN
θ value	2.36792 (rank : 408)	NC score	0.400953 (rank : 57)
Query Neighborhood Hits	534	Target Neighborhood Hits	794	Shared Neighborhood Hits	339
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FBXW4_HUMAN
θ value	2.36792 (rank : 409)	NC score	0.156566 (rank : 994)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	106
SwissProt Accessions	P57775, Q5SVS1, Q96IM6	Gene names	FBXW4, FBW4, SHFM3
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Dactylin).

GBLP_HUMAN
θ value	2.36792 (rank : 410)	NC score	0.218376 (rank : 758)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	146
SwissProt Accessions	P63244, P25388, P99049	Gene names	GNB2L1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase).

GBLP_MOUSE
θ value	2.36792 (rank : 411)	NC score	0.218376 (rank : 759)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	146
SwissProt Accessions	P68040, P25388, P99049	Gene names	Gnb2l1, Gnb2-rs1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase) (p205) (12-3).

MK08_HUMAN
θ value	2.36792 (rank : 412)	NC score	0.370928 (rank : 249)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	2.36792 (rank : 413)	NC score	0.371116 (rank : 247)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK10_HUMAN
θ value	2.36792 (rank : 414)	NC score	0.370259 (rank : 255)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	342
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	2.36792 (rank : 415)	NC score	0.370222 (rank : 256)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

NRK_HUMAN
θ value	2.36792 (rank : 416)	NC score	0.341526 (rank : 465)
Query Neighborhood Hits	534	Target Neighborhood Hits	931	Shared Neighborhood Hits	342
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

TAB3_MOUSE
θ value	2.36792 (rank : 417)	NC score	0.017155 (rank : 1183)
Query Neighborhood Hits	534	Target Neighborhood Hits	273	Shared Neighborhood Hits	15
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

TBL1R_HUMAN
θ value	2.36792 (rank : 418)	NC score	0.204132 (rank : 854)
Query Neighborhood Hits	534	Target Neighborhood Hits	327	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BZK7, Q9H2I1, Q9H9A1	Gene names	TBL1XR1, IRA1, TBLR1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

TBL1R_MOUSE
θ value	2.36792 (rank : 419)	NC score	0.203930 (rank : 855)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BHJ5, Q3UWL6, Q8CBG4, Q8VEG3, Q9EQD4	Gene names	Tbl1xr1, Ira1, Tblr1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

WDR36_HUMAN
θ value	2.36792 (rank : 420)	NC score	0.202434 (rank : 861)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	139
SwissProt Accessions	Q8NI36, Q8N1Q2	Gene names	WDR36
Domain Architecture
Description	WD repeat protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP).

WDR61_HUMAN
θ value	2.36792 (rank : 421)	NC score	0.211803 (rank : 808)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	148
SwissProt Accessions	Q9GZS3, Q6IA22, Q7Z4X4	Gene names	WDR61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

WDR75_HUMAN
θ value	2.36792 (rank : 422)	NC score	0.175052 (rank : 956)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IWA0, Q96J10, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2	Gene names	WDR75
Domain Architecture	No domain graphic available
Description	WD repeat protein 75.

WDR79_HUMAN
θ value	2.36792 (rank : 423)	NC score	0.173042 (rank : 964)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

DAPK3_HUMAN
θ value	3.0926 (rank : 424)	NC score	0.381057 (rank : 190)
Query Neighborhood Hits	534	Target Neighborhood Hits	945	Shared Neighborhood Hits	343
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ERCC8_MOUSE
θ value	3.0926 (rank : 425)	NC score	0.206856 (rank : 837)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CFD5, Q3U066, Q8VDC4, Q9CWK7	Gene names	Ercc8, Ckn1, Csa
Domain Architecture	No domain graphic available
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog).

F5006_MOUSE
θ value	3.0926 (rank : 426)	NC score	0.396632 (rank : 76)
Query Neighborhood Hits	534	Target Neighborhood Hits	793	Shared Neighborhood Hits	337
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FOXP2_MOUSE
θ value	3.0926 (rank : 427)	NC score	0.012525 (rank : 1191)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	14
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

GOGA3_HUMAN
θ value	3.0926 (rank : 428)	NC score	0.007848 (rank : 1198)
Query Neighborhood Hits	534	Target Neighborhood Hits	1317	Shared Neighborhood Hits	43
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

HEAT1_HUMAN
θ value	3.0926 (rank : 429)	NC score	0.027064 (rank : 1176)
Query Neighborhood Hits	534	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H583, Q5T3Q8, Q9NW23	Gene names	HEATR1, BAP28
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 1 (Protein BAP28).

IRAK2_HUMAN
θ value	3.0926 (rank : 430)	NC score	0.267250 (rank : 611)
Query Neighborhood Hits	534	Target Neighborhood Hits	714	Shared Neighborhood Hits	306
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

NEK7_HUMAN
θ value	3.0926 (rank : 431)	NC score	0.350052 (rank : 429)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

PK1IP_MOUSE
θ value	3.0926 (rank : 432)	NC score	0.196547 (rank : 890)
Query Neighborhood Hits	534	Target Neighborhood Hits	313	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

PLAP_HUMAN
θ value	3.0926 (rank : 433)	NC score	0.192664 (rank : 899)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

PUSL1_HUMAN
θ value	3.0926 (rank : 434)	NC score	0.026848 (rank : 1177)
Query Neighborhood Hits	534	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0Z8	Gene names	PUSL1
Domain Architecture	No domain graphic available
Description	tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA-uridine isomerase-like 1) (tRNA pseudouridylate synthase-like 1).

TBL1X_HUMAN
θ value	3.0926 (rank : 435)	NC score	0.207304 (rank : 833)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	146
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

TBL1Y_HUMAN
θ value	3.0926 (rank : 436)	NC score	0.205502 (rank : 843)
Query Neighborhood Hits	534	Target Neighborhood Hits	331	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BQ87	Gene names	TBL1Y, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1Y (Transducin beta-like 1Y protein) (Transducin-beta-like 1, Y-linked).

TBLX_MOUSE
θ value	3.0926 (rank : 437)	NC score	0.206801 (rank : 838)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).

UTP15_MOUSE
θ value	3.0926 (rank : 438)	NC score	0.212817 (rank : 799)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	146
SwissProt Accessions	Q8C7V3, Q3TRG8, Q8K231	Gene names	Utp15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog (Src-associated protein SAW).

WDR53_MOUSE
θ value	3.0926 (rank : 439)	NC score	0.172566 (rank : 965)
Query Neighborhood Hits	534	Target Neighborhood Hits	254	Shared Neighborhood Hits	130
SwissProt Accessions	Q9DB94	Gene names	Wdr53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

ARAF_HUMAN
θ value	4.03905 (rank : 440)	NC score	0.292174 (rank : 570)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	346
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

AVR2A_HUMAN
θ value	4.03905 (rank : 441)	NC score	0.270287 (rank : 607)
Query Neighborhood Hits	534	Target Neighborhood Hits	767	Shared Neighborhood Hits	332
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	4.03905 (rank : 442)	NC score	0.270290 (rank : 606)
Query Neighborhood Hits	534	Target Neighborhood Hits	767	Shared Neighborhood Hits	332
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BMR1B_HUMAN
θ value	4.03905 (rank : 443)	NC score	0.252569 (rank : 630)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	326
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	4.03905 (rank : 444)	NC score	0.252883 (rank : 629)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	325
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

COR2A_MOUSE
θ value	4.03905 (rank : 445)	NC score	0.120667 (rank : 1076)
Query Neighborhood Hits	534	Target Neighborhood Hits	204	Shared Neighborhood Hits	117
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

EP400_HUMAN
θ value	4.03905 (rank : 446)	NC score	0.004511 (rank : 1200)
Query Neighborhood Hits	534	Target Neighborhood Hits	556	Shared Neighborhood Hits	15
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FBW1A_HUMAN
θ value	4.03905 (rank : 447)	NC score	0.205602 (rank : 841)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

FBXW7_HUMAN
θ value	4.03905 (rank : 448)	NC score	0.203596 (rank : 856)
Query Neighborhood Hits	534	Target Neighborhood Hits	433	Shared Neighborhood Hits	147
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

FOXP1_HUMAN
θ value	4.03905 (rank : 449)	NC score	0.012313 (rank : 1192)
Query Neighborhood Hits	534	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H334, Q9H332, Q9H333, Q9P0R1	Gene names	FOXP1
Domain Architecture
Description	Forkhead box protein P1.

PAK3_HUMAN
θ value	4.03905 (rank : 450)	NC score	0.358730 (rank : 383)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	344
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	4.03905 (rank : 451)	NC score	0.358897 (rank : 380)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PASK_HUMAN
θ value	4.03905 (rank : 452)	NC score	0.393498 (rank : 96)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	343
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PCQAP_HUMAN
θ value	4.03905 (rank : 453)	NC score	0.014568 (rank : 1187)
Query Neighborhood Hits	534	Target Neighborhood Hits	549	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PCTK1_HUMAN
θ value	4.03905 (rank : 454)	NC score	0.363455 (rank : 321)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	4.03905 (rank : 455)	NC score	0.363358 (rank : 322)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

RAF1_MOUSE
θ value	4.03905 (rank : 456)	NC score	0.290622 (rank : 575)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	347
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RT31_HUMAN
θ value	4.03905 (rank : 457)	NC score	0.026684 (rank : 1178)
Query Neighborhood Hits	534	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q92665, Q5VYC8, Q8WTV8	Gene names	MRPS31, IMOGN38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

SLK_HUMAN
θ value	4.03905 (rank : 458)	NC score	0.331719 (rank : 506)
Query Neighborhood Hits	534	Target Neighborhood Hits	1775	Shared Neighborhood Hits	350
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

TAOK3_HUMAN
θ value	4.03905 (rank : 459)	NC score	0.322713 (rank : 538)
Query Neighborhood Hits	534	Target Neighborhood Hits	1494	Shared Neighborhood Hits	352
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TF3C2_MOUSE
θ value	4.03905 (rank : 460)	NC score	0.063875 (rank : 1160)
Query Neighborhood Hits	534	Target Neighborhood Hits	165	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

UBXD3_MOUSE
θ value	4.03905 (rank : 461)	NC score	0.020992 (rank : 1180)
Query Neighborhood Hits	534	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

WDR22_MOUSE
θ value	4.03905 (rank : 462)	NC score	0.174256 (rank : 960)
Query Neighborhood Hits	534	Target Neighborhood Hits	302	Shared Neighborhood Hits	126
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

WDR4_HUMAN
θ value	4.03905 (rank : 463)	NC score	0.126685 (rank : 1064)
Query Neighborhood Hits	534	Target Neighborhood Hits	145	Shared Neighborhood Hits	97
SwissProt Accessions	P57081, Q9HCR3	Gene names	WDR4
Domain Architecture
Description	WD repeat protein 4.

WDR6_HUMAN
θ value	4.03905 (rank : 464)	NC score	0.156793 (rank : 992)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

WSB1_MOUSE
θ value	4.03905 (rank : 465)	NC score	0.198437 (rank : 882)
Query Neighborhood Hits	534	Target Neighborhood Hits	313	Shared Neighborhood Hits	148
SwissProt Accessions	O54927	Gene names	Wsb1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1).

ARAF_MOUSE
θ value	5.27518 (rank : 466)	NC score	0.291813 (rank : 571)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	347
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CDC2_HUMAN
θ value	5.27518 (rank : 467)	NC score	0.365595 (rank : 303)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

G3ST3_MOUSE
θ value	5.27518 (rank : 468)	NC score	0.010121 (rank : 1194)
Query Neighborhood Hits	534	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P61315	Gene names	Gal3st3
Domain Architecture	No domain graphic available
Description	Galactose-3-O-sulfotransferase 3 (EC 2.8.2.-) (Galbeta1-3GalNAc 3'- sulfotransferase) (Beta-galactose-3-O-sulfotransferase 3).

GBB5_HUMAN
θ value	5.27518 (rank : 469)	NC score	0.186219 (rank : 915)
Query Neighborhood Hits	534	Target Neighborhood Hits	299	Shared Neighborhood Hits	144
SwissProt Accessions	O14775, Q9HAU9	Gene names	GNB5
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

GBB5_MOUSE
θ value	5.27518 (rank : 470)	NC score	0.186459 (rank : 914)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	143
SwissProt Accessions	P62881, O35354, P54314, Q91WB3	Gene names	Gnb5
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

IP6K2_MOUSE
θ value	5.27518 (rank : 471)	NC score	0.009504 (rank : 1196)
Query Neighborhood Hits	534	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q80V72	Gene names	Ihpk2, Ip6k2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

IRAK1_HUMAN
θ value	5.27518 (rank : 472)	NC score	0.265135 (rank : 615)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	319
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

KPCD_MOUSE
θ value	5.27518 (rank : 473)	NC score	0.362526 (rank : 337)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	342
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MRCKA_HUMAN
θ value	5.27518 (rank : 474)	NC score	0.335467 (rank : 488)
Query Neighborhood Hits	534	Target Neighborhood Hits	1999	Shared Neighborhood Hits	356
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NEK6_HUMAN
θ value	5.27518 (rank : 475)	NC score	0.350481 (rank : 427)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

PAK2_HUMAN
θ value	5.27518 (rank : 476)	NC score	0.359347 (rank : 373)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	344
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	5.27518 (rank : 477)	NC score	0.359591 (rank : 371)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PER3_HUMAN
θ value	5.27518 (rank : 478)	NC score	0.014690 (rank : 1185)
Query Neighborhood Hits	534	Target Neighborhood Hits	479	Shared Neighborhood Hits	19
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

SF3B1_HUMAN
θ value	5.27518 (rank : 479)	NC score	0.031036 (rank : 1174)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SLK_MOUSE
θ value	5.27518 (rank : 480)	NC score	0.331910 (rank : 505)
Query Neighborhood Hits	534	Target Neighborhood Hits	1798	Shared Neighborhood Hits	351
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK24_MOUSE
θ value	5.27518 (rank : 481)	NC score	0.332917 (rank : 502)
Query Neighborhood Hits	534	Target Neighborhood Hits	856	Shared Neighborhood Hits	344
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STRAP_HUMAN
θ value	5.27518 (rank : 482)	NC score	0.206280 (rank : 840)
Query Neighborhood Hits	534	Target Neighborhood Hits	272	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

STRAP_MOUSE
θ value	5.27518 (rank : 483)	NC score	0.206428 (rank : 839)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

SYCP1_HUMAN
θ value	5.27518 (rank : 484)	NC score	0.005274 (rank : 1199)
Query Neighborhood Hits	534	Target Neighborhood Hits	1313	Shared Neighborhood Hits	36
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

T22D2_HUMAN
θ value	5.27518 (rank : 485)	NC score	0.017506 (rank : 1182)
Query Neighborhood Hits	534	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TBL3_HUMAN
θ value	5.27518 (rank : 486)	NC score	0.213457 (rank : 794)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	143
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

TF3C2_HUMAN
θ value	5.27518 (rank : 487)	NC score	0.054991 (rank : 1165)
Query Neighborhood Hits	534	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

WDFY1_HUMAN
θ value	5.27518 (rank : 488)	NC score	0.149673 (rank : 1014)
Query Neighborhood Hits	534	Target Neighborhood Hits	305	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDR34_MOUSE
θ value	5.27518 (rank : 489)	NC score	0.060782 (rank : 1163)
Query Neighborhood Hits	534	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	Q5U4F6	Gene names	Wdr34
Domain Architecture	No domain graphic available
Description	WD repeat protein 34.

WDR47_HUMAN
θ value	5.27518 (rank : 490)	NC score	0.185058 (rank : 921)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	133
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

WDR47_MOUSE
θ value	5.27518 (rank : 491)	NC score	0.186780 (rank : 913)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	135
SwissProt Accessions	Q8CGF6, Q80TP4	Gene names	Wdr47, Kiaa0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

WNK2_HUMAN
θ value	5.27518 (rank : 492)	NC score	0.327246 (rank : 529)
Query Neighborhood Hits	534	Target Neighborhood Hits	1407	Shared Neighborhood Hits	341
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

BUB3_HUMAN
θ value	6.88961 (rank : 493)	NC score	0.156808 (rank : 991)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O43684, O43685	Gene names	BUB3
Domain Architecture
Description	Mitotic checkpoint protein BUB3.

BUB3_MOUSE
θ value	6.88961 (rank : 494)	NC score	0.155966 (rank : 998)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	116
SwissProt Accessions	Q9WVA3, P97397	Gene names	Bub3
Domain Architecture
Description	Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5).

CN145_HUMAN
θ value	6.88961 (rank : 495)	NC score	0.004239 (rank : 1201)
Query Neighborhood Hits	534	Target Neighborhood Hits	1196	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CORO6_MOUSE
θ value	6.88961 (rank : 496)	NC score	0.120541 (rank : 1077)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q920M5, Q920M3, Q920M4	Gene names	Coro6
Domain Architecture	No domain graphic available
Description	Coronin-6 (Clipin E).

DAPK1_MOUSE
θ value	6.88961 (rank : 497)	NC score	0.339347 (rank : 475)
Query Neighborhood Hits	534	Target Neighborhood Hits	1138	Shared Neighborhood Hits	343
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

FOXP2_HUMAN
θ value	6.88961 (rank : 498)	NC score	0.010681 (rank : 1193)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	14
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

IKKE_MOUSE
θ value	6.88961 (rank : 499)	NC score	0.354192 (rank : 411)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	338
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCT_HUMAN
θ value	6.88961 (rank : 500)	NC score	0.366065 (rank : 299)
Query Neighborhood Hits	534	Target Neighborhood Hits	897	Shared Neighborhood Hits	343
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MEP50_HUMAN
θ value	6.88961 (rank : 501)	NC score	0.203208 (rank : 858)
Query Neighborhood Hits	534	Target Neighborhood Hits	268	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BQA1, Q96GK4, Q9BWY3	Gene names	WDR77, MEP50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

NEK4_HUMAN
θ value	6.88961 (rank : 502)	NC score	0.355159 (rank : 405)
Query Neighborhood Hits	534	Target Neighborhood Hits	883	Shared Neighborhood Hits	344
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NOL10_MOUSE
θ value	6.88961 (rank : 503)	NC score	0.023745 (rank : 1179)
Query Neighborhood Hits	534	Target Neighborhood Hits	206	Shared Neighborhood Hits	33
SwissProt Accessions	Q5RJG1	Gene names	Nol10, Gm67
Domain Architecture	No domain graphic available
Description	Nucleolar protein 10.

NUBP1_HUMAN
θ value	6.88961 (rank : 504)	NC score	0.008758 (rank : 1197)
Query Neighborhood Hits	534	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P53384	Gene names	NUBP1, NBP, NBP1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

STK16_MOUSE
θ value	6.88961 (rank : 505)	NC score	0.351581 (rank : 423)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	342
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK6_HUMAN
θ value	6.88961 (rank : 506)	NC score	0.375243 (rank : 221)
Query Neighborhood Hits	534	Target Neighborhood Hits	916	Shared Neighborhood Hits	344
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	6.88961 (rank : 507)	NC score	0.376551 (rank : 216)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	344
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TLE1_HUMAN
θ value	6.88961 (rank : 508)	NC score	0.136573 (rank : 1053)
Query Neighborhood Hits	534	Target Neighborhood Hits	485	Shared Neighborhood Hits	138
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
θ value	6.88961 (rank : 509)	NC score	0.136361 (rank : 1054)
Query Neighborhood Hits	534	Target Neighborhood Hits	491	Shared Neighborhood Hits	137
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

WDR22_HUMAN
θ value	6.88961 (rank : 510)	NC score	0.171651 (rank : 968)
Query Neighborhood Hits	534	Target Neighborhood Hits	328	Shared Neighborhood Hits	125
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

WDR81_MOUSE
θ value	6.88961 (rank : 511)	NC score	0.124320 (rank : 1069)
Query Neighborhood Hits	534	Target Neighborhood Hits	228	Shared Neighborhood Hits	115
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

BPA1_MOUSE
θ value	8.99809 (rank : 512)	NC score	0.000725 (rank : 1203)
Query Neighborhood Hits	534	Target Neighborhood Hits	1477	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CDC2_MOUSE
θ value	8.99809 (rank : 513)	NC score	0.365556 (rank : 304)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

DAPK1_HUMAN
θ value	8.99809 (rank : 514)	NC score	0.340217 (rank : 471)
Query Neighborhood Hits	534	Target Neighborhood Hits	1130	Shared Neighborhood Hits	343
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DCAK3_HUMAN
θ value	8.99809 (rank : 515)	NC score	0.391898 (rank : 105)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	345
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	8.99809 (rank : 516)	NC score	0.390031 (rank : 115)
Query Neighborhood Hits	534	Target Neighborhood Hits	922	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DDB2_HUMAN
θ value	8.99809 (rank : 517)	NC score	0.133668 (rank : 1056)
Query Neighborhood Hits	534	Target Neighborhood Hits	175	Shared Neighborhood Hits	102
SwissProt Accessions	Q92466, Q76E54, Q76E55, Q76E56, Q76E57	Gene names	DDB2
Domain Architecture
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) (DDB p48 subunit) (DDBb) (UV-damaged DNA-binding protein 2) (UV-DDB 2).

DYRK2_HUMAN
θ value	8.99809 (rank : 518)	NC score	0.361384 (rank : 352)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	336
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

HIPK3_HUMAN
θ value	8.99809 (rank : 519)	NC score	0.341741 (rank : 464)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	335
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

IKKE_HUMAN
θ value	8.99809 (rank : 520)	NC score	0.355067 (rank : 406)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	338
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KCTD3_HUMAN
θ value	8.99809 (rank : 521)	NC score	0.014621 (rank : 1186)
Query Neighborhood Hits	534	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y597, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16	Gene names	KCTD3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3 (NY-REN-45 antigen).

KCTD3_MOUSE
θ value	8.99809 (rank : 522)	NC score	0.014486 (rank : 1188)
Query Neighborhood Hits	534	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFX3, Q6P7X4	Gene names	Kctd3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3.

KPCD_HUMAN
θ value	8.99809 (rank : 523)	NC score	0.361850 (rank : 341)
Query Neighborhood Hits	534	Target Neighborhood Hits	900	Shared Neighborhood Hits	342
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MINK1_HUMAN
θ value	8.99809 (rank : 524)	NC score	0.332796 (rank : 504)
Query Neighborhood Hits	534	Target Neighborhood Hits	1477	Shared Neighborhood Hits	346
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	8.99809 (rank : 525)	NC score	0.332903 (rank : 503)
Query Neighborhood Hits	534	Target Neighborhood Hits	1451	Shared Neighborhood Hits	346
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYLK2_HUMAN
θ value	8.99809 (rank : 526)	NC score	0.371771 (rank : 242)
Query Neighborhood Hits	534	Target Neighborhood Hits	920	Shared Neighborhood Hits	340
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK1_HUMAN
θ value	8.99809 (rank : 527)	NC score	0.362836 (rank : 332)
Query Neighborhood Hits	534	Target Neighborhood Hits	1129	Shared Neighborhood Hits	349
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	8.99809 (rank : 528)	NC score	0.359972 (rank : 364)
Query Neighborhood Hits	534	Target Neighborhood Hits	1311	Shared Neighborhood Hits	346
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PLAP_MOUSE
θ value	8.99809 (rank : 529)	NC score	0.188299 (rank : 908)
Query Neighborhood Hits	534	Target Neighborhood Hits	261	Shared Neighborhood Hits	140
SwissProt Accessions	P27612, Q8C6C4	Gene names	Plaa, Plap
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP).

PRP17_HUMAN
θ value	8.99809 (rank : 530)	NC score	0.198250 (rank : 884)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	145
SwissProt Accessions	O60508, O75471, Q9UPG1	Gene names	CDC40, PRP17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (hPRP17) (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3).

PRP17_MOUSE
θ value	8.99809 (rank : 531)	NC score	0.196608 (rank : 888)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	145
SwissProt Accessions	Q9DC48	Gene names	Cdc40, Prp17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).

RN169_HUMAN
θ value	8.99809 (rank : 532)	NC score	0.016859 (rank : 1184)
Query Neighborhood Hits	534	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

STTP1_MOUSE
θ value	8.99809 (rank : 533)	NC score	0.147097 (rank : 1019)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	128
SwissProt Accessions	Q91WG4, Q3TIH5, Q3TIT0, Q8CBW6, Q9ESY7	Gene names	Statip1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1).

ZF106_HUMAN
θ value	8.99809 (rank : 534)	NC score	0.140655 (rank : 1039)
Query Neighborhood Hits	534	Target Neighborhood Hits	470	Shared Neighborhood Hits	117
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

A16L1_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.190712 (rank : 903)
Query Neighborhood Hits	534	Target Neighborhood Hits	664	Shared Neighborhood Hits	159
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

A16L1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.185531 (rank : 918)
Query Neighborhood Hits	534	Target Neighborhood Hits	776	Shared Neighborhood Hits	159
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

AAAS_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.098533 (rank : 1111)
Query Neighborhood Hits	534	Target Neighborhood Hits	154	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NRG9, Q9NWI6, Q9UG19	Gene names	AAAS, ADRACALA
Domain Architecture
Description	Aladin (Adracalin).

AAAS_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.084164 (rank : 1124)
Query Neighborhood Hits	534	Target Neighborhood Hits	144	Shared Neighborhood Hits	83
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

AAK1_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.353704 (rank : 413)
Query Neighborhood Hits	534	Target Neighborhood Hits	1077	Shared Neighborhood Hits	343
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.353235 (rank : 414)
Query Neighborhood Hits	534	Target Neighborhood Hits	1051	Shared Neighborhood Hits	340
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAMP_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.198976 (rank : 879)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	136
SwissProt Accessions	Q13685, Q8WUJ9, Q96H92	Gene names	AAMP
Domain Architecture
Description	Angio-associated migratory cell protein.

AATK_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.218499 (rank : 756)
Query Neighborhood Hits	534	Target Neighborhood Hits	1243	Shared Neighborhood Hits	336
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.210719 (rank : 812)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	330
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.235131 (rank : 667)
Query Neighborhood Hits	534	Target Neighborhood Hits	1220	Shared Neighborhood Hits	342
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.235011 (rank : 668)
Query Neighborhood Hits	534	Target Neighborhood Hits	1178	Shared Neighborhood Hits	341
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.235493 (rank : 665)
Query Neighborhood Hits	534	Target Neighborhood Hits	1045	Shared Neighborhood Hits	339
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.217322 (rank : 764)
Query Neighborhood Hits	534	Target Neighborhood Hits	1140	Shared Neighborhood Hits	336
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.215475 (rank : 777)
Query Neighborhood Hits	534	Target Neighborhood Hits	1080	Shared Neighborhood Hits	336
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.248892 (rank : 639)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	328
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.248772 (rank : 640)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	328
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.212878 (rank : 798)
Query Neighborhood Hits	534	Target Neighborhood Hits	709	Shared Neighborhood Hits	287
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.216249 (rank : 773)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	288
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.226361 (rank : 717)
Query Neighborhood Hits	534	Target Neighborhood Hits	716	Shared Neighborhood Hits	308
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.234170 (rank : 680)
Query Neighborhood Hits	534	Target Neighborhood Hits	739	Shared Neighborhood Hits	321
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.251357 (rank : 633)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	325
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.253742 (rank : 628)
Query Neighborhood Hits	534	Target Neighborhood Hits	768	Shared Neighborhood Hits	326
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AHI1_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.132899 (rank : 1057)
Query Neighborhood Hits	534	Target Neighborhood Hits	537	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AL2S2_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.323475 (rank : 537)
Query Neighborhood Hits	534	Target Neighborhood Hits	727	Shared Neighborhood Hits	324
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.317119 (rank : 543)
Query Neighborhood Hits	534	Target Neighborhood Hits	709	Shared Neighborhood Hits	317
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ALK_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.171176 (rank : 971)
Query Neighborhood Hits	534	Target Neighborhood Hits	795	Shared Neighborhood Hits	309
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.170561 (rank : 972)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	313
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.177482 (rank : 948)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	283
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.224853 (rank : 722)
Query Neighborhood Hits	534	Target Neighborhood Hits	1075	Shared Neighborhood Hits	332
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.228598 (rank : 707)
Query Neighborhood Hits	534	Target Neighborhood Hits	1072	Shared Neighborhood Hits	335
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.114004 (rank : 1088)
Query Neighborhood Hits	534	Target Neighborhood Hits	612	Shared Neighborhood Hits	203
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.119651 (rank : 1080)
Query Neighborhood Hits	534	Target Neighborhood Hits	600	Shared Neighborhood Hits	202
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.143014 (rank : 1029)
Query Neighborhood Hits	534	Target Neighborhood Hits	646	Shared Neighborhood Hits	222
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.131995 (rank : 1059)
Query Neighborhood Hits	534	Target Neighborhood Hits	607	Shared Neighborhood Hits	217
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARBK1_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.370849 (rank : 251)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	342
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.371775 (rank : 241)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.372892 (rank : 233)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARC1A_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.054592 (rank : 1166)
Query Neighborhood Hits	534	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q92747, Q7Z5U8, Q86WU5, Q8IXQ0	Gene names	ARPC1A, SOP2L
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein).

ARC1A_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.053758 (rank : 1167)
Query Neighborhood Hits	534	Target Neighborhood Hits	120	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0Q6, Q3UL75	Gene names	Arpc1a, Sid329
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329).

ARC1B_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.069563 (rank : 1150)
Query Neighborhood Hits	534	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	O15143, Q9BU00	Gene names	ARPC1B, ARC41
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

ARC1B_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.064512 (rank : 1158)
Query Neighborhood Hits	534	Target Neighborhood Hits	133	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV32	Gene names	Arpc1b
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

AURKB_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.381023 (rank : 191)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

BLK_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.222900 (rank : 735)
Query Neighborhood Hits	534	Target Neighborhood Hits	994	Shared Neighborhood Hits	343
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.222041 (rank : 739)
Query Neighborhood Hits	534	Target Neighborhood Hits	992	Shared Neighborhood Hits	343
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMP2K_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.355821 (rank : 398)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	339
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.359680 (rank : 369)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	340
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMPR2_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.245748 (rank : 646)
Query Neighborhood Hits	534	Target Neighborhood Hits	736	Shared Neighborhood Hits	297
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.245047 (rank : 649)
Query Neighborhood Hits	534	Target Neighborhood Hits	738	Shared Neighborhood Hits	296
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.252517 (rank : 631)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.252197 (rank : 632)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	325
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMX_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.231993 (rank : 693)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	333
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.231610 (rank : 695)
Query Neighborhood Hits	534	Target Neighborhood Hits	912	Shared Neighborhood Hits	334
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BOP1_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.136589 (rank : 1052)
Query Neighborhood Hits	534	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	Q14137, Q969Z6, Q96IS8, Q9BSA7, Q9BVM0	Gene names	BOP1, KIAA0124
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

BOP1_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.149005 (rank : 1015)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	130
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

BRAF1_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.285952 (rank : 588)
Query Neighborhood Hits	534	Target Neighborhood Hits	883	Shared Neighborhood Hits	344
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BTK_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.234257 (rank : 677)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	340
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.233809 (rank : 683)
Query Neighborhood Hits	534	Target Neighborhood Hits	1017	Shared Neighborhood Hits	340
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BUB1_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.173184 (rank : 963)
Query Neighborhood Hits	534	Target Neighborhood Hits	543	Shared Neighborhood Hits	216
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

BUB1_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.257007 (rank : 624)
Query Neighborhood Hits	534	Target Neighborhood Hits	583	Shared Neighborhood Hits	287
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CAF1B_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.177492 (rank : 947)
Query Neighborhood Hits	534	Target Neighborhood Hits	345	Shared Neighborhood Hits	137
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

CAF1B_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.177372 (rank : 949)
Query Neighborhood Hits	534	Target Neighborhood Hits	385	Shared Neighborhood Hits	138
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

CAMKV_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.396395 (rank : 83)
Query Neighborhood Hits	534	Target Neighborhood Hits	1084	Shared Neighborhood Hits	334
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.399418 (rank : 63)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	333
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CCRK_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.361612 (rank : 346)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	340
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.363266 (rank : 323)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	340
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD2L6_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.357231 (rank : 393)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	340
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.357119 (rank : 395)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	340
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CDC7_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.339744 (rank : 474)
Query Neighborhood Hits	534	Target Neighborhood Hits	652	Shared Neighborhood Hits	321
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.344571 (rank : 453)
Query Neighborhood Hits	534	Target Neighborhood Hits	641	Shared Neighborhood Hits	324
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDK2_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.361847 (rank : 342)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.359306 (rank : 375)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	341
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.366146 (rank : 298)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK7_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.360645 (rank : 360)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.360602 (rank : 361)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	342
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK8_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.355271 (rank : 404)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	341
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CI096_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.336268 (rank : 481)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	332
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CIR1A_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.096072 (rank : 1112)
Query Neighborhood Hits	534	Target Neighborhood Hits	158	Shared Neighborhood Hits	88
SwissProt Accessions	Q969X6, Q8NCD9, Q8TF14, Q96SP0, Q96SR9, Q96SZ9, Q96T13, Q9BWK6	Gene names	CIRH1A, KIAA1988
Domain Architecture
Description	Cirhin.

CIR1A_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.089076 (rank : 1121)
Query Neighborhood Hits	534	Target Neighborhood Hits	155	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R2N2, Q62306, Q69Z48, Q6NVG9, Q8VEL5	Gene names	Cirh1a, Kiaa1988, Tex292
Domain Architecture	No domain graphic available
Description	Cirhin (Testis-expressed gene 292 protein).

CLK1_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.349801 (rank : 434)
Query Neighborhood Hits	534	Target Neighborhood Hits	756	Shared Neighborhood Hits	327
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.348223 (rank : 439)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	327
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.346220 (rank : 450)
Query Neighborhood Hits	534	Target Neighborhood Hits	752	Shared Neighborhood Hits	325
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.342542 (rank : 460)
Query Neighborhood Hits	534	Target Neighborhood Hits	743	Shared Neighborhood Hits	325
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.335724 (rank : 487)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	328
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.335454 (rank : 489)
Query Neighborhood Hits	534	Target Neighborhood Hits	761	Shared Neighborhood Hits	328
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK4_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.344591 (rank : 452)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.343802 (rank : 456)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

COPA_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.214352 (rank : 785)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	141
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

COR1A_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.105780 (rank : 1105)
Query Neighborhood Hits	534	Target Neighborhood Hits	240	Shared Neighborhood Hits	122
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

COR1A_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.109194 (rank : 1099)
Query Neighborhood Hits	534	Target Neighborhood Hits	243	Shared Neighborhood Hits	127
SwissProt Accessions	O89053, Q7TMU0, Q9R1Y8, Q9R288	Gene names	Coro1a, Coro1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

COR1B_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.105973 (rank : 1104)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BR76	Gene names	CORO1B
Domain Architecture
Description	Coronin-1B (Coronin-2).

COR1B_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.104613 (rank : 1109)
Query Neighborhood Hits	534	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q9WUM3, Q3UEB1, Q9CVA2	Gene names	Coro1b
Domain Architecture
Description	Coronin-1B (Coronin-2).

COR1C_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.112917 (rank : 1093)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	130
SwissProt Accessions	Q9ULV4, Q9NSK5	Gene names	CORO1C, CRNN4
Domain Architecture
Description	Coronin-1C (Coronin-3) (hCRNN4).

COR1C_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.113177 (rank : 1092)
Query Neighborhood Hits	534	Target Neighborhood Hits	251	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WUM4, Q8VCQ5	Gene names	Coro1c
Domain Architecture
Description	Coronin-1C (Coronin-3).

COR2A_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.110844 (rank : 1097)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	112
SwissProt Accessions	Q92828, Q92829, Q9BWS5	Gene names	CORO2A, IR10, WDR2
Domain Architecture
Description	Coronin-2A (WD repeat-containing protein 2) (IR10).

COR2B_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.118302 (rank : 1081)
Query Neighborhood Hits	534	Target Neighborhood Hits	233	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

COR2B_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.117079 (rank : 1082)
Query Neighborhood Hits	534	Target Neighborhood Hits	235	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BH44, Q6P5U9	Gene names	Coro2b
Domain Architecture	No domain graphic available
Description	Coronin-2B.

CORO7_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.137458 (rank : 1049)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	144
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

CORO7_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.137603 (rank : 1048)
Query Neighborhood Hits	534	Target Neighborhood Hits	312	Shared Neighborhood Hits	145
SwissProt Accessions	Q9D2V7, Q3UDJ4, Q6P8Y8, Q8C9V7	Gene names	Coro7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

CSF1R_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.156655 (rank : 993)
Query Neighborhood Hits	534	Target Neighborhood Hits	943	Shared Neighborhood Hits	331
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.157532 (rank : 989)
Query Neighborhood Hits	534	Target Neighborhood Hits	983	Shared Neighborhood Hits	329
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSKP_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.369039 (rank : 270)
Query Neighborhood Hits	534	Target Neighborhood Hits	1022	Shared Neighborhood Hits	339
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.370139 (rank : 257)
Query Neighborhood Hits	534	Target Neighborhood Hits	1027	Shared Neighborhood Hits	339
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSK_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.240361 (rank : 655)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	343
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.246324 (rank : 645)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	343
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DC1I2_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.066286 (rank : 1154)
Query Neighborhood Hits	534	Target Neighborhood Hits	201	Shared Neighborhood Hits	83
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DC1I2_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.067168 (rank : 1153)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	83
SwissProt Accessions	O88487, Q3TGH7	Gene names	Dync1i2, Dnci2, Dncic2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DCAK1_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.379812 (rank : 196)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	343
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.379639 (rank : 197)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.381267 (rank : 188)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	342
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	θ > 10 (rank : 644)	NC score	0.380396 (rank : 194)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DDB2_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.119838 (rank : 1078)
Query Neighborhood Hits	534	Target Neighborhood Hits	175	Shared Neighborhood Hits	104
SwissProt Accessions	Q99J79	Gene names	Ddb2
Domain Architecture	No domain graphic available
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).

DDR1_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.187522 (rank : 911)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	327
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.188596 (rank : 906)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	325
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.204731 (rank : 850)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	327
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.208903 (rank : 824)
Query Neighborhood Hits	534	Target Neighborhood Hits	813	Shared Neighborhood Hits	328
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DMWD_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.123663 (rank : 1072)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	119
SwissProt Accessions	Q08274	Gene names	Dmwd, Dm9
Domain Architecture
Description	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (DMR-N9 protein).

DMXL1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.082817 (rank : 1125)
Query Neighborhood Hits	534	Target Neighborhood Hits	259	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DMXL1_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.095798 (rank : 1113)
Query Neighborhood Hits	534	Target Neighborhood Hits	257	Shared Neighborhood Hits	114
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DMXL2_HUMAN
θ value	θ > 10 (rank : 653)	NC score	0.105332 (rank : 1107)
Query Neighborhood Hits	534	Target Neighborhood Hits	374	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

DNAI1_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.082740 (rank : 1126)
Query Neighborhood Hits	534	Target Neighborhood Hits	148	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UI46, Q9UEZ8	Gene names	DNAI1
Domain Architecture
Description	Dynein intermediate chain 1, axonemal (Axonemal dynein intermediate chain 1).

DNAI2_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.069637 (rank : 1149)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	73
SwissProt Accessions	Q9GZS0, Q9H179, Q9NT53	Gene names	DNAI2
Domain Architecture
Description	Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2).

DUET_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.346519 (rank : 448)
Query Neighborhood Hits	534	Target Neighborhood Hits	1220	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.350067 (rank : 428)
Query Neighborhood Hits	534	Target Neighborhood Hits	764	Shared Neighborhood Hits	331
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.350020 (rank : 432)
Query Neighborhood Hits	534	Target Neighborhood Hits	762	Shared Neighborhood Hits	331
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.350037 (rank : 431)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	333
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 660)	NC score	0.352149 (rank : 419)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	334
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.354061 (rank : 412)
Query Neighborhood Hits	534	Target Neighborhood Hits	798	Shared Neighborhood Hits	335
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.350992 (rank : 424)
Query Neighborhood Hits	534	Target Neighborhood Hits	750	Shared Neighborhood Hits	324
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

E2AK1_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.334292 (rank : 492)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.337107 (rank : 479)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	341
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.343876 (rank : 455)
Query Neighborhood Hits	534	Target Neighborhood Hits	856	Shared Neighborhood Hits	342
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK4_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.348073 (rank : 440)
Query Neighborhood Hits	534	Target Neighborhood Hits	1012	Shared Neighborhood Hits	344
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.212362 (rank : 803)
Query Neighborhood Hits	534	Target Neighborhood Hits	939	Shared Neighborhood Hits	340
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.213166 (rank : 795)
Query Neighborhood Hits	534	Target Neighborhood Hits	927	Shared Neighborhood Hits	340
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMAL1_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.126070 (rank : 1067)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	111
SwissProt Accessions	O00423	Gene names	EML1, EMAP1, EMAPL, EMAPL1
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1).

EMAL2_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.131780 (rank : 1060)
Query Neighborhood Hits	534	Target Neighborhood Hits	217	Shared Neighborhood Hits	116
SwissProt Accessions	O95834, Q9UG50	Gene names	EML2, EMAP2, EMAPL2
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2).

EMAL4_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.138339 (rank : 1045)
Query Neighborhood Hits	534	Target Neighborhood Hits	306	Shared Neighborhood Hits	123
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

EPHA1_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.206894 (rank : 835)
Query Neighborhood Hits	534	Target Neighborhood Hits	997	Shared Neighborhood Hits	334
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.202533 (rank : 860)
Query Neighborhood Hits	534	Target Neighborhood Hits	958	Shared Neighborhood Hits	332
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.209722 (rank : 819)
Query Neighborhood Hits	534	Target Neighborhood Hits	1021	Shared Neighborhood Hits	338
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.210965 (rank : 811)
Query Neighborhood Hits	534	Target Neighborhood Hits	1020	Shared Neighborhood Hits	338
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.213857 (rank : 789)
Query Neighborhood Hits	534	Target Neighborhood Hits	1005	Shared Neighborhood Hits	342
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.209008 (rank : 823)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	342
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.205573 (rank : 842)
Query Neighborhood Hits	534	Target Neighborhood Hits	975	Shared Neighborhood Hits	337
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.205501 (rank : 844)
Query Neighborhood Hits	534	Target Neighborhood Hits	982	Shared Neighborhood Hits	337
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.212688 (rank : 800)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	342
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.220488 (rank : 747)
Query Neighborhood Hits	534	Target Neighborhood Hits	950	Shared Neighborhood Hits	342
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.184101 (rank : 924)
Query Neighborhood Hits	534	Target Neighborhood Hits	959	Shared Neighborhood Hits	342
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.185853 (rank : 917)
Query Neighborhood Hits	534	Target Neighborhood Hits	946	Shared Neighborhood Hits	342
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.213081 (rank : 797)
Query Neighborhood Hits	534	Target Neighborhood Hits	1053	Shared Neighborhood Hits	342
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.213713 (rank : 792)
Query Neighborhood Hits	534	Target Neighborhood Hits	1025	Shared Neighborhood Hits	342
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.207450 (rank : 831)
Query Neighborhood Hits	534	Target Neighborhood Hits	956	Shared Neighborhood Hits	341
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.202252 (rank : 863)
Query Neighborhood Hits	534	Target Neighborhood Hits	969	Shared Neighborhood Hits	340
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.164450 (rank : 984)
Query Neighborhood Hits	534	Target Neighborhood Hits	960	Shared Neighborhood Hits	315
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.214526 (rank : 783)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	338
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.204879 (rank : 848)
Query Neighborhood Hits	534	Target Neighborhood Hits	983	Shared Neighborhood Hits	337
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.204942 (rank : 847)
Query Neighborhood Hits	534	Target Neighborhood Hits	982	Shared Neighborhood Hits	337
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.201065 (rank : 868)
Query Neighborhood Hits	534	Target Neighborhood Hits	996	Shared Neighborhood Hits	337
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.200798 (rank : 869)
Query Neighborhood Hits	534	Target Neighborhood Hits	996	Shared Neighborhood Hits	337
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.210010 (rank : 818)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	340
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.212275 (rank : 805)
Query Neighborhood Hits	534	Target Neighborhood Hits	1013	Shared Neighborhood Hits	340
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.148286 (rank : 1017)
Query Neighborhood Hits	534	Target Neighborhood Hits	912	Shared Neighborhood Hits	276
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.150941 (rank : 1009)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	286
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.207254 (rank : 834)
Query Neighborhood Hits	534	Target Neighborhood Hits	1073	Shared Neighborhood Hits	342
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.208248 (rank : 826)
Query Neighborhood Hits	534	Target Neighborhood Hits	918	Shared Neighborhood Hits	341
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.200146 (rank : 874)
Query Neighborhood Hits	534	Target Neighborhood Hits	918	Shared Neighborhood Hits	332
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.198033 (rank : 886)
Query Neighborhood Hits	534	Target Neighborhood Hits	898	Shared Neighborhood Hits	336
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.215036 (rank : 781)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	341
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERN2_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.344341 (rank : 454)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	339
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FAK1_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.233680 (rank : 684)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	340
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.234128 (rank : 682)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	340
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.227966 (rank : 710)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	337
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.229460 (rank : 706)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	336
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FBXW2_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.176240 (rank : 952)
Query Neighborhood Hits	534	Target Neighborhood Hits	260	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FBXW2_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.178213 (rank : 943)
Query Neighborhood Hits	534	Target Neighborhood Hits	249	Shared Neighborhood Hits	130
SwissProt Accessions	Q60584	Gene names	Fbxw2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FBXW8_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.078712 (rank : 1133)
Query Neighborhood Hits	534	Target Neighborhood Hits	192	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

FBXW8_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.065913 (rank : 1156)
Query Neighborhood Hits	534	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

FBXW9_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.145008 (rank : 1026)
Query Neighborhood Hits	534	Target Neighborhood Hits	184	Shared Neighborhood Hits	108
SwissProt Accessions	Q5XUX1, Q9BT89	Gene names	FBXW9, FBW9
Domain Architecture	No domain graphic available
Description	F-box/WD repeat protein 9 (F-box and WD-40 domain protein 9).

FER_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.235680 (rank : 664)
Query Neighborhood Hits	534	Target Neighborhood Hits	1278	Shared Neighborhood Hits	339
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.247507 (rank : 643)
Query Neighborhood Hits	534	Target Neighborhood Hits	978	Shared Neighborhood Hits	344
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.249151 (rank : 638)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	344
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.222489 (rank : 737)
Query Neighborhood Hits	534	Target Neighborhood Hits	1069	Shared Neighborhood Hits	344
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 717)	NC score	0.222563 (rank : 736)
Query Neighborhood Hits	534	Target Neighborhood Hits	1068	Shared Neighborhood Hits	344
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.222473 (rank : 738)
Query Neighborhood Hits	534	Target Neighborhood Hits	1062	Shared Neighborhood Hits	342
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.223151 (rank : 733)
Query Neighborhood Hits	534	Target Neighborhood Hits	1062	Shared Neighborhood Hits	342
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.215986 (rank : 775)
Query Neighborhood Hits	534	Target Neighborhood Hits	1042	Shared Neighborhood Hits	342
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.214254 (rank : 788)
Query Neighborhood Hits	534	Target Neighborhood Hits	1059	Shared Neighborhood Hits	342
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.209430 (rank : 821)
Query Neighborhood Hits	534	Target Neighborhood Hits	1037	Shared Neighborhood Hits	340
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.198303 (rank : 883)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	339
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FGR_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.212231 (rank : 806)
Query Neighborhood Hits	534	Target Neighborhood Hits	1067	Shared Neighborhood Hits	340
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 725)	NC score	0.212000 (rank : 807)
Query Neighborhood Hits	534	Target Neighborhood Hits	1069	Shared Neighborhood Hits	341
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLT3_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.176038 (rank : 953)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	332
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.174645 (rank : 959)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	334
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FRK_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.227346 (rank : 713)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	342
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.225305 (rank : 721)
Query Neighborhood Hits	534	Target Neighborhood Hits	1078	Shared Neighborhood Hits	343
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.221792 (rank : 741)
Query Neighborhood Hits	534	Target Neighborhood Hits	1073	Shared Neighborhood Hits	341
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FZR_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.183712 (rank : 929)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UM11, O75869, Q86U66, Q96NW8, Q9UI96, Q9ULH8, Q9UM10, Q9UNQ1, Q9Y2T8	Gene names	FZR1, CDH1, FYR, FZR, KIAA1242
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (hCDH1) (CDC20-like protein 1).

FZR_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.183835 (rank : 927)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R1K5	Gene names	Fzr1, Fyr, Fzr
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog).

GBB1_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.175180 (rank : 954)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62873, P04697, P04901	Gene names	GNB1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

GBB1_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.175180 (rank : 955)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62874, P04697, P04901	Gene names	Gnb1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

GBB2_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.173604 (rank : 961)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62879, P11016, P54312	Gene names	GNB2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

GBB2_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.173604 (rank : 962)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62880, P11016, P54312	Gene names	Gnb2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

GBB3_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.172131 (rank : 967)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	135
SwissProt Accessions	P16520, Q9BQC0	Gene names	GNB3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

GBB3_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.171480 (rank : 970)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	136
SwissProt Accessions	Q61011	Gene names	Gnb3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

GBB4_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.174779 (rank : 958)
Query Neighborhood Hits	534	Target Neighborhood Hits	288	Shared Neighborhood Hits	139
SwissProt Accessions	Q9HAV0	Gene names	GNB4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

GBB4_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.174788 (rank : 957)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	137
SwissProt Accessions	P29387, Q3TJJ1, Q8R475, Q9JHX8	Gene names	Gnb4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

GNB1L_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.143864 (rank : 1028)
Query Neighborhood Hits	534	Target Neighborhood Hits	221	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

GNB1L_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.161190 (rank : 986)
Query Neighborhood Hits	534	Target Neighborhood Hits	231	Shared Neighborhood Hits	123
SwissProt Accessions	Q9EQ15, Q8R1F3, Q9CWP2, Q9D3Y1	Gene names	Gnb1l, Estm55, Wdr14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF).

GRK4_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.357647 (rank : 391)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	338
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.358614 (rank : 384)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	337
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.365720 (rank : 301)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	338
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.365614 (rank : 302)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	338
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.361563 (rank : 349)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	339
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.361310 (rank : 353)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	339
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.373108 (rank : 230)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	343
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GSK3A_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.369007 (rank : 272)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	338
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.370052 (rank : 260)
Query Neighborhood Hits	534	Target Neighborhood Hits	801	Shared Neighborhood Hits	340
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.370059 (rank : 259)
Query Neighborhood Hits	534	Target Neighborhood Hits	800	Shared Neighborhood Hits	340
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GUC2C_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.127766 (rank : 1063)
Query Neighborhood Hits	534	Target Neighborhood Hits	624	Shared Neighborhood Hits	227
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.156132 (rank : 997)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	284
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.142701 (rank : 1032)
Query Neighborhood Hits	534	Target Neighborhood Hits	692	Shared Neighborhood Hits	274
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.168228 (rank : 976)
Query Neighborhood Hits	534	Target Neighborhood Hits	740	Shared Neighborhood Hits	294
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.147498 (rank : 1018)
Query Neighborhood Hits	534	Target Neighborhood Hits	644	Shared Neighborhood Hits	252
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCK_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.221840 (rank : 740)
Query Neighborhood Hits	534	Target Neighborhood Hits	1035	Shared Neighborhood Hits	343
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.219010 (rank : 751)
Query Neighborhood Hits	534	Target Neighborhood Hits	1029	Shared Neighborhood Hits	345
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HIPK2_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.341307 (rank : 467)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	331
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.341128 (rank : 468)
Query Neighborhood Hits	534	Target Neighborhood Hits	871	Shared Neighborhood Hits	331
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HIPK3_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.340137 (rank : 472)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	332
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK4_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.357782 (rank : 390)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	338
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

IF122_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.151594 (rank : 1008)
Query Neighborhood Hits	534	Target Neighborhood Hits	244	Shared Neighborhood Hits	122
SwissProt Accessions	Q9HBG6	Gene names	IFT122, WDR10, WDR140
Domain Architecture
Description	Intraflagellar transport 122 homolog (WD repeat protein 10).

IFT80_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.110846 (rank : 1096)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	94
SwissProt Accessions	Q9P2H3	Gene names	IFT80, KIAA1374, WDR56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

IFT80_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.109091 (rank : 1101)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K057	Gene names	Ift80, Wdr56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

IGF1R_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.179892 (rank : 941)
Query Neighborhood Hits	534	Target Neighborhood Hits	977	Shared Neighborhood Hits	337
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.180677 (rank : 938)
Query Neighborhood Hits	534	Target Neighborhood Hits	973	Shared Neighborhood Hits	335
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKKA_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.342292 (rank : 461)
Query Neighborhood Hits	534	Target Neighborhood Hits	863	Shared Neighborhood Hits	342
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.342747 (rank : 458)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.345948 (rank : 451)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	340
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.346324 (rank : 449)
Query Neighborhood Hits	534	Target Neighborhood Hits	984	Shared Neighborhood Hits	340
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

ILK1_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.111885 (rank : 1095)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	226
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.107224 (rank : 1102)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	222
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.110057 (rank : 1098)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	227
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.182498 (rank : 932)
Query Neighborhood Hits	534	Target Neighborhood Hits	950	Shared Neighborhood Hits	336
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.183617 (rank : 930)
Query Neighborhood Hits	534	Target Neighborhood Hits	961	Shared Neighborhood Hits	334
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.194667 (rank : 894)
Query Neighborhood Hits	534	Target Neighborhood Hits	963	Shared Neighborhood Hits	343
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.193491 (rank : 897)
Query Neighborhood Hits	534	Target Neighborhood Hits	968	Shared Neighborhood Hits	338
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.256796 (rank : 625)
Query Neighborhood Hits	534	Target Neighborhood Hits	784	Shared Neighborhood Hits	319
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK4_HUMAN
θ value	θ > 10 (rank : 781)	NC score	0.305227 (rank : 550)
Query Neighborhood Hits	534	Target Neighborhood Hits	816	Shared Neighborhood Hits	340
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.309603 (rank : 547)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	338
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 783)	NC score	0.234189 (rank : 679)
Query Neighborhood Hits	534	Target Neighborhood Hits	1016	Shared Neighborhood Hits	341
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 784)	NC score	0.234856 (rank : 670)
Query Neighborhood Hits	534	Target Neighborhood Hits	985	Shared Neighborhood Hits	341
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.254373 (rank : 627)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.249287 (rank : 637)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	339
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.262399 (rank : 618)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	345
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.262725 (rank : 616)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	343
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.258925 (rank : 620)
Query Neighborhood Hits	534	Target Neighborhood Hits	827	Shared Neighborhood Hits	342
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.267695 (rank : 610)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	341
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K2002_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.136694 (rank : 1051)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	145
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.113967 (rank : 1089)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	132
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KC1AL_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.297806 (rank : 558)
Query Neighborhood Hits	534	Target Neighborhood Hits	734	Shared Neighborhood Hits	330
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
θ value	θ > 10 (rank : 794)	NC score	0.301726 (rank : 554)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	329
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.301726 (rank : 555)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	329
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1D_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.284581 (rank : 591)
Query Neighborhood Hits	534	Target Neighborhood Hits	737	Shared Neighborhood Hits	329
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.284576 (rank : 592)
Query Neighborhood Hits	534	Target Neighborhood Hits	737	Shared Neighborhood Hits	329
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.286287 (rank : 585)
Query Neighborhood Hits	534	Target Neighborhood Hits	732	Shared Neighborhood Hits	328
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.286270 (rank : 586)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	328
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.284796 (rank : 590)
Query Neighborhood Hits	534	Target Neighborhood Hits	708	Shared Neighborhood Hits	328
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 801)	NC score	0.286041 (rank : 587)
Query Neighborhood Hits	534	Target Neighborhood Hits	713	Shared Neighborhood Hits	328
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G2_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.269481 (rank : 609)
Query Neighborhood Hits	534	Target Neighborhood Hits	693	Shared Neighborhood Hits	324
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	θ > 10 (rank : 803)	NC score	0.271441 (rank : 605)
Query Neighborhood Hits	534	Target Neighborhood Hits	695	Shared Neighborhood Hits	325
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.283985 (rank : 593)
Query Neighborhood Hits	534	Target Neighborhood Hits	711	Shared Neighborhood Hits	328
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KGP1A_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.370061 (rank : 258)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	342
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.369778 (rank : 263)
Query Neighborhood Hits	534	Target Neighborhood Hits	921	Shared Neighborhood Hits	342
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.369805 (rank : 261)
Query Neighborhood Hits	534	Target Neighborhood Hits	922	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.372303 (rank : 237)
Query Neighborhood Hits	534	Target Neighborhood Hits	1029	Shared Neighborhood Hits	344
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KI21A_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.074660 (rank : 1144)
Query Neighborhood Hits	534	Target Neighborhood Hits	1543	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

KI21A_MOUSE
θ value	θ > 10 (rank : 810)	NC score	0.075550 (rank : 1142)
Query Neighborhood Hits	534	Target Neighborhood Hits	1317	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

KI21B_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.079360 (rank : 1132)
Query Neighborhood Hits	534	Target Neighborhood Hits	1017	Shared Neighborhood Hits	155
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

KI21B_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.076696 (rank : 1139)
Query Neighborhood Hits	534	Target Neighborhood Hits	997	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

KIT_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.176779 (rank : 951)
Query Neighborhood Hits	534	Target Neighborhood Hits	953	Shared Neighborhood Hits	330
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.177250 (rank : 950)
Query Neighborhood Hits	534	Target Neighborhood Hits	949	Shared Neighborhood Hits	332
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KKCC1_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.377153 (rank : 214)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 816)	NC score	0.378288 (rank : 209)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.377219 (rank : 213)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	340
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 818)	NC score	0.377075 (rank : 215)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	340
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.355426 (rank : 401)
Query Neighborhood Hits	534	Target Neighborhood Hits	1070	Shared Neighborhood Hits	341
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.354537 (rank : 407)
Query Neighborhood Hits	534	Target Neighborhood Hits	1067	Shared Neighborhood Hits	340
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.352458 (rank : 416)
Query Neighborhood Hits	534	Target Neighborhood Hits	1121	Shared Neighborhood Hits	341
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.351936 (rank : 420)
Query Neighborhood Hits	534	Target Neighborhood Hits	1117	Shared Neighborhood Hits	341
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCT_MOUSE
θ value	θ > 10 (rank : 823)	NC score	0.361985 (rank : 340)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	340
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPSH2_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.383630 (rank : 166)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	339
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6C1_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.328105 (rank : 524)
Query Neighborhood Hits	534	Target Neighborhood Hits	682	Shared Neighborhood Hits	322
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.327411 (rank : 528)
Query Neighborhood Hits	534	Target Neighborhood Hits	700	Shared Neighborhood Hits	318
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSYK_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.235352 (rank : 666)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	339
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.234831 (rank : 672)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	339
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCK_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.220677 (rank : 746)
Query Neighborhood Hits	534	Target Neighborhood Hits	987	Shared Neighborhood Hits	343
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.224826 (rank : 723)
Query Neighborhood Hits	534	Target Neighborhood Hits	981	Shared Neighborhood Hits	343
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIMK1_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.288116 (rank : 582)
Query Neighborhood Hits	534	Target Neighborhood Hits	1005	Shared Neighborhood Hits	342
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.287614 (rank : 583)
Query Neighborhood Hits	534	Target Neighborhood Hits	1008	Shared Neighborhood Hits	343
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.292436 (rank : 569)
Query Neighborhood Hits	534	Target Neighborhood Hits	986	Shared Neighborhood Hits	340
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.291181 (rank : 573)
Query Neighborhood Hits	534	Target Neighborhood Hits	998	Shared Neighborhood Hits	341
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.270122 (rank : 608)
Query Neighborhood Hits	534	Target Neighborhood Hits	1237	Shared Neighborhood Hits	342
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.265214 (rank : 614)
Query Neighborhood Hits	534	Target Neighborhood Hits	1267	Shared Neighborhood Hits	342
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.267126 (rank : 612)
Query Neighborhood Hits	534	Target Neighborhood Hits	1382	Shared Neighborhood Hits	349
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.261458 (rank : 619)
Query Neighborhood Hits	534	Target Neighborhood Hits	1359	Shared Neighborhood Hits	342
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.166302 (rank : 981)
Query Neighborhood Hits	534	Target Neighborhood Hits	774	Shared Neighborhood Hits	310
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.167042 (rank : 979)
Query Neighborhood Hits	534	Target Neighborhood Hits	770	Shared Neighborhood Hits	302
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LYN_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.232080 (rank : 692)
Query Neighborhood Hits	534	Target Neighborhood Hits	1022	Shared Neighborhood Hits	343
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.231973 (rank : 694)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	343
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYST_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.079752 (rank : 1130)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	99
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

LYST_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.074577 (rank : 1145)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	98
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

M3K10_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.281265 (rank : 598)
Query Neighborhood Hits	534	Target Neighborhood Hits	1071	Shared Neighborhood Hits	344
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.280593 (rank : 599)
Query Neighborhood Hits	534	Target Neighborhood Hits	1136	Shared Neighborhood Hits	349
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.294255 (rank : 566)
Query Neighborhood Hits	534	Target Neighborhood Hits	940	Shared Neighborhood Hits	344
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.294161 (rank : 567)
Query Neighborhood Hits	534	Target Neighborhood Hits	957	Shared Neighborhood Hits	343
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.300822 (rank : 556)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	343
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K14_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.358610 (rank : 385)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	341
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K14_MOUSE
θ value	θ > 10 (rank : 851)	NC score	0.360389 (rank : 363)
Query Neighborhood Hits	534	Target Neighborhood Hits	889	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K1_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.355721 (rank : 399)
Query Neighborhood Hits	534	Target Neighborhood Hits	952	Shared Neighborhood Hits	343
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_MOUSE
θ value	θ > 10 (rank : 853)	NC score	0.362324 (rank : 338)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	343
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K7_HUMAN
θ value	θ > 10 (rank : 854)	NC score	0.288857 (rank : 581)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	346
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 855)	NC score	0.289070 (rank : 579)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	346
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K9_HUMAN
θ value	θ > 10 (rank : 856)	NC score	0.281730 (rank : 597)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	346
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.272833 (rank : 602)
Query Neighborhood Hits	534	Target Neighborhood Hits	1087	Shared Neighborhood Hits	345
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 858)	NC score	0.341843 (rank : 462)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	342
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 859)	NC score	0.341749 (rank : 463)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.350955 (rank : 425)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	342
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.350879 (rank : 426)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	342
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

MAPK2_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.384290 (rank : 162)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	337
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.384622 (rank : 161)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	337
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.385862 (rank : 144)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	338
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.384810 (rank : 159)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	338
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.396256 (rank : 85)
Query Neighborhood Hits	534	Target Neighborhood Hits	795	Shared Neighborhood Hits	337
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.396476 (rank : 80)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	337
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK3_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.387404 (rank : 129)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	343
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MATK_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.230360 (rank : 701)
Query Neighborhood Hits	534	Target Neighborhood Hits	954	Shared Neighborhood Hits	342
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.231374 (rank : 697)
Query Neighborhood Hits	534	Target Neighborhood Hits	952	Shared Neighborhood Hits	342
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MERTK_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.192639 (rank : 901)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	332
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.200595 (rank : 871)
Query Neighborhood Hits	534	Target Neighborhood Hits	974	Shared Neighborhood Hits	328
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.208735 (rank : 825)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	338
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.210688 (rank : 813)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	339
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MK11_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.355511 (rank : 400)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	341
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK12_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.358945 (rank : 379)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 877)	NC score	0.360555 (rank : 362)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	342
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 878)	NC score	0.359121 (rank : 378)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 879)	NC score	0.359778 (rank : 366)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.358452 (rank : 387)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 881)	NC score	0.359312 (rank : 374)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MKNK1_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.396473 (rank : 81)
Query Neighborhood Hits	534	Target Neighborhood Hits	701	Shared Neighborhood Hits	333
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MLKL_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.152561 (rank : 1006)
Query Neighborhood Hits	534	Target Neighborhood Hits	600	Shared Neighborhood Hits	203
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.210318 (rank : 815)
Query Neighborhood Hits	534	Target Neighborhood Hits	707	Shared Neighborhood Hits	289
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.282275 (rank : 596)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	341
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.282996 (rank : 595)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	341
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.283502 (rank : 594)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.285328 (rank : 589)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	344
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.333901 (rank : 494)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.333709 (rank : 496)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.333391 (rank : 497)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	338
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.333355 (rank : 498)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	338
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.327834 (rank : 527)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	337
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 894)	NC score	0.328935 (rank : 521)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.329710 (rank : 514)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	341
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 896)	NC score	0.329625 (rank : 516)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	341
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.326108 (rank : 533)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	340
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 898)	NC score	0.328358 (rank : 523)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	340
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 899)	NC score	0.329434 (rank : 517)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	337
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 900)	NC score	0.330053 (rank : 513)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	338
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 901)	NC score	0.340057 (rank : 473)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MRCKB_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.322093 (rank : 539)
Query Neighborhood Hits	534	Target Neighborhood Hits	2239	Shared Neighborhood Hits	351
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_MOUSE
θ value	θ > 10 (rank : 903)	NC score	0.326008 (rank : 534)
Query Neighborhood Hits	534	Target Neighborhood Hits	2180	Shared Neighborhood Hits	346
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKG_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.357343 (rank : 392)
Query Neighborhood Hits	534	Target Neighborhood Hits	1519	Shared Neighborhood Hits	347
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
θ value	θ > 10 (rank : 905)	NC score	0.356044 (rank : 397)
Query Neighborhood Hits	534	Target Neighborhood Hits	1466	Shared Neighborhood Hits	349
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MST4_HUMAN
θ value	θ > 10 (rank : 906)	NC score	0.331155 (rank : 511)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	342
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 907)	NC score	0.331237 (rank : 509)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	342
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 908)	NC score	0.186168 (rank : 916)
Query Neighborhood Hits	534	Target Neighborhood Hits	1074	Shared Neighborhood Hits	333
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 909)	NC score	0.184989 (rank : 922)
Query Neighborhood Hits	534	Target Neighborhood Hits	1057	Shared Neighborhood Hits	333
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYO3A_HUMAN
θ value	θ > 10 (rank : 910)	NC score	0.294529 (rank : 564)
Query Neighborhood Hits	534	Target Neighborhood Hits	1033	Shared Neighborhood Hits	343
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 911)	NC score	0.299159 (rank : 557)
Query Neighborhood Hits	534	Target Neighborhood Hits	902	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 912)	NC score	0.294499 (rank : 565)
Query Neighborhood Hits	534	Target Neighborhood Hits	923	Shared Neighborhood Hits	341
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NBEAL_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.072153 (rank : 1146)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	92
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

NEDD1_HUMAN
θ value	θ > 10 (rank : 914)	NC score	0.150612 (rank : 1010)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	124
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

NEDD1_MOUSE
θ value	θ > 10 (rank : 915)	NC score	0.151822 (rank : 1007)
Query Neighborhood Hits	534	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

NEK11_HUMAN
θ value	θ > 10 (rank : 916)	NC score	0.341122 (rank : 469)
Query Neighborhood Hits	534	Target Neighborhood Hits	1043	Shared Neighborhood Hits	345
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 917)	NC score	0.343582 (rank : 457)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	342
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK2_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.363530 (rank : 319)
Query Neighborhood Hits	534	Target Neighborhood Hits	908	Shared Neighborhood Hits	342
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 919)	NC score	0.365274 (rank : 305)
Query Neighborhood Hits	534	Target Neighborhood Hits	876	Shared Neighborhood Hits	340
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK8_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.359632 (rank : 370)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 921)	NC score	0.359744 (rank : 367)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NLE1_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.204249 (rank : 852)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NVX2, O60868, Q9BU54	Gene names	NLE1
Domain Architecture
Description	Notchless homolog 1.

NLE1_MOUSE
θ value	θ > 10 (rank : 923)	NC score	0.204996 (rank : 846)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	148
SwissProt Accessions	Q8VEJ4	Gene names	Nle1
Domain Architecture
Description	Notchless homolog 1.

NRBP_HUMAN
θ value	θ > 10 (rank : 924)	NC score	0.158648 (rank : 987)
Query Neighborhood Hits	534	Target Neighborhood Hits	448	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 925)	NC score	0.153941 (rank : 1001)
Query Neighborhood Hits	534	Target Neighborhood Hits	442	Shared Neighborhood Hits	155
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NTKL_HUMAN
θ value	θ > 10 (rank : 926)	NC score	0.157338 (rank : 990)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	124
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 927)	NC score	0.193648 (rank : 896)
Query Neighborhood Hits	534	Target Neighborhood Hits	326	Shared Neighborhood Hits	151
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

NTRK1_HUMAN
θ value	θ > 10 (rank : 928)	NC score	0.202359 (rank : 862)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	334
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.221756 (rank : 742)
Query Neighborhood Hits	534	Target Neighborhood Hits	1081	Shared Neighborhood Hits	342
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.221530 (rank : 743)
Query Neighborhood Hits	534	Target Neighborhood Hits	1088	Shared Neighborhood Hits	342
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.205224 (rank : 845)
Query Neighborhood Hits	534	Target Neighborhood Hits	1115	Shared Neighborhood Hits	338
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NUP37_HUMAN
θ value	θ > 10 (rank : 932)	NC score	0.113812 (rank : 1090)
Query Neighborhood Hits	534	Target Neighborhood Hits	153	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NFH4, Q9H644	Gene names	NUP37
Domain Architecture
Description	Nucleoporin Nup37 (p37).

NUP37_MOUSE
θ value	θ > 10 (rank : 933)	NC score	0.121041 (rank : 1075)
Query Neighborhood Hits	534	Target Neighborhood Hits	159	Shared Neighborhood Hits	92
SwissProt Accessions	Q9CWU9	Gene names	Nup37
Domain Architecture
Description	Nucleoporin Nup37.

NUP43_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.126332 (rank : 1065)
Query Neighborhood Hits	534	Target Neighborhood Hits	198	Shared Neighborhood Hits	106
SwissProt Accessions	Q8NFH3, Q9H8S0	Gene names	NUP43
Domain Architecture
Description	Nucleoporin Nup43 (p42).

NUP43_MOUSE
θ value	θ > 10 (rank : 935)	NC score	0.126229 (rank : 1066)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	100
SwissProt Accessions	P59235	Gene names	Nup43
Domain Architecture
Description	Nucleoporin Nup43.

PAK1_HUMAN
θ value	θ > 10 (rank : 936)	NC score	0.355383 (rank : 403)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	342
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 937)	NC score	0.355420 (rank : 402)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	343
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PCTK3_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.359199 (rank : 377)
Query Neighborhood Hits	534	Target Neighborhood Hits	827	Shared Neighborhood Hits	340
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 939)	NC score	0.361069 (rank : 355)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.366413 (rank : 297)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	340
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 941)	NC score	0.366036 (rank : 300)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	340
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PGFRA_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.181524 (rank : 934)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	335
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.181057 (rank : 935)
Query Neighborhood Hits	534	Target Neighborhood Hits	975	Shared Neighborhood Hits	334
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.177559 (rank : 946)
Query Neighborhood Hits	534	Target Neighborhood Hits	962	Shared Neighborhood Hits	335
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 945)	NC score	0.177931 (rank : 944)
Query Neighborhood Hits	534	Target Neighborhood Hits	960	Shared Neighborhood Hits	336
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PK1IP_HUMAN
θ value	θ > 10 (rank : 946)	NC score	0.188125 (rank : 909)
Query Neighborhood Hits	534	Target Neighborhood Hits	277	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NWT1, Q5T4J2, Q96QJ8, Q96T87	Gene names	PAK1IP1, PIP1, WDR84
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (PAK/PLC-interacting protein 1) (hPIP1) (WD repeat protein 84).

PKN1_HUMAN
θ value	θ > 10 (rank : 947)	NC score	0.358835 (rank : 381)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	343
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 948)	NC score	0.359272 (rank : 376)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	345
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 949)	NC score	0.361520 (rank : 350)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	345
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 950)	NC score	0.362005 (rank : 339)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 951)	NC score	0.363728 (rank : 315)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 952)	NC score	0.362672 (rank : 334)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	349
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 953)	NC score	0.370348 (rank : 254)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	340
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 954)	NC score	0.374361 (rank : 223)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	340
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 955)	NC score	0.367263 (rank : 289)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	342
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 956)	NC score	0.367111 (rank : 291)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	341
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 957)	NC score	0.372554 (rank : 236)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	342
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 958)	NC score	0.372058 (rank : 238)
Query Neighborhood Hits	534	Target Neighborhood Hits	863	Shared Neighborhood Hits	342
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PMYT1_HUMAN
θ value	θ > 10 (rank : 959)	NC score	0.364929 (rank : 310)
Query Neighborhood Hits	534	Target Neighborhood Hits	814	Shared Neighborhood Hits	338
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 960)	NC score	0.366568 (rank : 296)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	343
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PREB_HUMAN
θ value	θ > 10 (rank : 961)	NC score	0.093077 (rank : 1114)
Query Neighborhood Hits	534	Target Neighborhood Hits	163	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HCU5, Q9UH94	Gene names	PREB, SEC12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

PREB_MOUSE
θ value	θ > 10 (rank : 962)	NC score	0.087358 (rank : 1122)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUQ2, Q9QZ99	Gene names	Preb, Sec12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

PRP4B_HUMAN
θ value	θ > 10 (rank : 963)	NC score	0.335826 (rank : 485)
Query Neighborhood Hits	534	Target Neighborhood Hits	1030	Shared Neighborhood Hits	333
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 964)	NC score	0.334921 (rank : 491)
Query Neighborhood Hits	534	Target Neighborhood Hits	1040	Shared Neighborhood Hits	332
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PRPK_HUMAN
θ value	θ > 10 (rank : 965)	NC score	0.075958 (rank : 1141)
Query Neighborhood Hits	534	Target Neighborhood Hits	131	Shared Neighborhood Hits	75
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 966)	NC score	0.071379 (rank : 1148)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	73
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTK6_HUMAN
θ value	θ > 10 (rank : 967)	NC score	0.247925 (rank : 642)
Query Neighborhood Hits	534	Target Neighborhood Hits	1020	Shared Neighborhood Hits	340
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 968)	NC score	0.244345 (rank : 650)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	343
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 969)	NC score	0.200741 (rank : 870)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	328
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PWP1_HUMAN
θ value	θ > 10 (rank : 970)	NC score	0.172149 (rank : 966)
Query Neighborhood Hits	534	Target Neighborhood Hits	261	Shared Neighborhood Hits	129
SwissProt Accessions	Q13610	Gene names	PWP1
Domain Architecture
Description	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502).

PWP1_MOUSE
θ value	θ > 10 (rank : 971)	NC score	0.177567 (rank : 945)
Query Neighborhood Hits	534	Target Neighborhood Hits	278	Shared Neighborhood Hits	138
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

PWP2_HUMAN
θ value	θ > 10 (rank : 972)	NC score	0.189086 (rank : 905)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	142
SwissProt Accessions	Q15269, Q96A77	Gene names	PWP2H, PWP2
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

PWP2_MOUSE
θ value	θ > 10 (rank : 973)	NC score	0.185217 (rank : 919)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	141
SwissProt Accessions	Q8BU03, Q8BTR0	Gene names	Pwp2h
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

PXK_HUMAN
θ value	θ > 10 (rank : 974)	NC score	0.071382 (rank : 1147)
Query Neighborhood Hits	534	Target Neighborhood Hits	216	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 975)	NC score	0.091169 (rank : 1116)
Query Neighborhood Hits	534	Target Neighborhood Hits	320	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RAE1L_HUMAN
θ value	θ > 10 (rank : 976)	NC score	0.150027 (rank : 1012)
Query Neighborhood Hits	534	Target Neighborhood Hits	222	Shared Neighborhood Hits	126
SwissProt Accessions	P78406, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6	Gene names	RAE1, MRNP41
Domain Architecture
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

RAE1L_MOUSE
θ value	θ > 10 (rank : 977)	NC score	0.150416 (rank : 1011)
Query Neighborhood Hits	534	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	Q8C570, Q3UKD4	Gene names	Rae1, Mrnp41
Domain Architecture	No domain graphic available
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

RAF1_HUMAN
θ value	θ > 10 (rank : 978)	NC score	0.287600 (rank : 584)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	345
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RET_HUMAN
θ value	θ > 10 (rank : 979)	NC score	0.218982 (rank : 752)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	335
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 980)	NC score	0.218932 (rank : 753)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	335
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RFWD2_HUMAN
θ value	θ > 10 (rank : 981)	NC score	0.153857 (rank : 1002)
Query Neighborhood Hits	534	Target Neighborhood Hits	518	Shared Neighborhood Hits	132
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	θ > 10 (rank : 982)	NC score	0.153839 (rank : 1003)
Query Neighborhood Hits	534	Target Neighborhood Hits	535	Shared Neighborhood Hits	134
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RIPK1_MOUSE
θ value	θ > 10 (rank : 983)	NC score	0.291772 (rank : 572)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	342
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 984)	NC score	0.272396 (rank : 603)
Query Neighborhood Hits	534	Target Neighborhood Hits	774	Shared Neighborhood Hits	327
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 985)	NC score	0.272236 (rank : 604)
Query Neighborhood Hits	534	Target Neighborhood Hits	776	Shared Neighborhood Hits	325
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 986)	NC score	0.295830 (rank : 561)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 987)	NC score	0.305377 (rank : 549)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	338
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 988)	NC score	0.218155 (rank : 761)
Query Neighborhood Hits	534	Target Neighborhood Hits	1094	Shared Neighborhood Hits	335
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RK_HUMAN
θ value	θ > 10 (rank : 989)	NC score	0.363860 (rank : 314)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	340
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 990)	NC score	0.365062 (rank : 306)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RN5A_HUMAN
θ value	θ > 10 (rank : 991)	NC score	0.064743 (rank : 1157)
Query Neighborhood Hits	534	Target Neighborhood Hits	608	Shared Neighborhood Hits	167
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RN5A_MOUSE
θ value	θ > 10 (rank : 992)	NC score	0.142851 (rank : 1030)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	298
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RON_HUMAN
θ value	θ > 10 (rank : 993)	NC score	0.210050 (rank : 817)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	340
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 994)	NC score	0.204194 (rank : 853)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	340
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 995)	NC score	0.209402 (rank : 822)
Query Neighborhood Hits	534	Target Neighborhood Hits	1018	Shared Neighborhood Hits	336
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 996)	NC score	0.210158 (rank : 816)
Query Neighborhood Hits	534	Target Neighborhood Hits	1025	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 997)	NC score	0.198166 (rank : 885)
Query Neighborhood Hits	534	Target Neighborhood Hits	1014	Shared Neighborhood Hits	338
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 998)	NC score	0.183915 (rank : 926)
Query Neighborhood Hits	534	Target Neighborhood Hits	1000	Shared Neighborhood Hits	331
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 999)	NC score	0.197916 (rank : 887)
Query Neighborhood Hits	534	Target Neighborhood Hits	907	Shared Neighborhood Hits	325
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RPKL1_HUMAN
θ value	θ > 10 (rank : 1000)	NC score	0.335748 (rank : 486)
Query Neighborhood Hits	534	Target Neighborhood Hits	708	Shared Neighborhood Hits	315
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 1001)	NC score	0.336168 (rank : 482)
Query Neighborhood Hits	534	Target Neighborhood Hits	704	Shared Neighborhood Hits	312
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPTOR_HUMAN
θ value	θ > 10 (rank : 1002)	NC score	0.063408 (rank : 1161)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RPTOR_MOUSE
θ value	θ > 10 (rank : 1003)	NC score	0.058138 (rank : 1164)
Query Neighborhood Hits	534	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

RYK_HUMAN
θ value	θ > 10 (rank : 1004)	NC score	0.142711 (rank : 1031)
Query Neighborhood Hits	534	Target Neighborhood Hits	701	Shared Neighborhood Hits	287
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1005)	NC score	0.152746 (rank : 1004)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	292
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SBK1_HUMAN
θ value	θ > 10 (rank : 1006)	NC score	0.371254 (rank : 245)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	340
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 1007)	NC score	0.371061 (rank : 248)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	339
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SCAP_HUMAN
θ value	θ > 10 (rank : 1008)	NC score	0.140891 (rank : 1038)
Query Neighborhood Hits	534	Target Neighborhood Hits	368	Shared Neighborhood Hits	114
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

SCYL2_HUMAN
θ value	θ > 10 (rank : 1009)	NC score	0.266574 (rank : 613)
Query Neighborhood Hits	534	Target Neighborhood Hits	632	Shared Neighborhood Hits	251
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1010)	NC score	0.258620 (rank : 621)
Query Neighborhood Hits	534	Target Neighborhood Hits	603	Shared Neighborhood Hits	241
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SEC13_HUMAN
θ value	θ > 10 (rank : 1011)	NC score	0.141401 (rank : 1036)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	99
SwissProt Accessions	P55735, Q9BRM6, Q9BUG7	Gene names	SEC13L1, SEC13R
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

SEC13_MOUSE
θ value	θ > 10 (rank : 1012)	NC score	0.143969 (rank : 1027)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D1M0, Q99M12, Q9D712	Gene names	Sec13l1
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

SEH1L_HUMAN
θ value	θ > 10 (rank : 1013)	NC score	0.148941 (rank : 1016)
Query Neighborhood Hits	534	Target Neighborhood Hits	145	Shared Neighborhood Hits	90
SwissProt Accessions	Q96EE3, Q8NFU6, Q96MH3, Q9C069	Gene names	SEH1L, SEC13L, SEH1
Domain Architecture
Description	Nucleoporin SEH1-like (SEC13-like protein).

SRC_HUMAN
θ value	θ > 10 (rank : 1014)	NC score	0.219412 (rank : 749)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	341
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 1015)	NC score	0.220450 (rank : 748)
Query Neighborhood Hits	534	Target Neighborhood Hits	1033	Shared Neighborhood Hits	341
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_HUMAN
θ value	θ > 10 (rank : 1016)	NC score	0.229537 (rank : 705)
Query Neighborhood Hits	534	Target Neighborhood Hits	946	Shared Neighborhood Hits	343
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 1017)	NC score	0.232281 (rank : 689)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	343
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRPK1_HUMAN
θ value	θ > 10 (rank : 1018)	NC score	0.235755 (rank : 663)
Query Neighborhood Hits	534	Target Neighborhood Hits	706	Shared Neighborhood Hits	300
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	θ > 10 (rank : 1019)	NC score	0.236219 (rank : 660)
Query Neighborhood Hits	534	Target Neighborhood Hits	639	Shared Neighborhood Hits	303
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
θ value	θ > 10 (rank : 1020)	NC score	0.235956 (rank : 661)
Query Neighborhood Hits	534	Target Neighborhood Hits	664	Shared Neighborhood Hits	299
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	θ > 10 (rank : 1021)	NC score	0.234543 (rank : 673)
Query Neighborhood Hits	534	Target Neighborhood Hits	765	Shared Neighborhood Hits	303
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

ST17A_HUMAN
θ value	θ > 10 (rank : 1022)	NC score	0.378613 (rank : 206)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	339
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 1023)	NC score	0.375430 (rank : 219)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	339
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 1024)	NC score	0.374964 (rank : 222)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	340
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 1025)	NC score	0.368194 (rank : 283)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 1026)	NC score	0.367171 (rank : 290)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 1027)	NC score	0.369803 (rank : 262)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 1028)	NC score	0.369700 (rank : 264)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	342
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.372633 (rank : 235)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 1030)	NC score	0.372796 (rank : 234)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	342
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

STK10_HUMAN
θ value	θ > 10 (rank : 1031)	NC score	0.321192 (rank : 542)
Query Neighborhood Hits	534	Target Neighborhood Hits	1921	Shared Neighborhood Hits	355
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 1032)	NC score	0.312441 (rank : 546)
Query Neighborhood Hits	534	Target Neighborhood Hits	2132	Shared Neighborhood Hits	357
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 1033)	NC score	0.383589 (rank : 168)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	342
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK23_HUMAN
θ value	θ > 10 (rank : 1034)	NC score	0.223748 (rank : 729)
Query Neighborhood Hits	534	Target Neighborhood Hits	556	Shared Neighborhood Hits	288
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	θ > 10 (rank : 1035)	NC score	0.224103 (rank : 728)
Query Neighborhood Hits	534	Target Neighborhood Hits	572	Shared Neighborhood Hits	291
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK24_HUMAN
θ value	θ > 10 (rank : 1036)	NC score	0.331441 (rank : 507)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK25_HUMAN
θ value	θ > 10 (rank : 1037)	NC score	0.331312 (rank : 508)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	342
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 1038)	NC score	0.330655 (rank : 512)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK31_HUMAN
θ value	θ > 10 (rank : 1039)	NC score	0.141440 (rank : 1035)
Query Neighborhood Hits	534	Target Neighborhood Hits	570	Shared Neighborhood Hits	177
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1040)	NC score	0.112114 (rank : 1094)
Query Neighborhood Hits	534	Target Neighborhood Hits	474	Shared Neighborhood Hits	154
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 1041)	NC score	0.363018 (rank : 330)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	340
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK3_HUMAN
θ value	θ > 10 (rank : 1042)	NC score	0.334023 (rank : 493)
Query Neighborhood Hits	534	Target Neighborhood Hits	861	Shared Neighborhood Hits	340
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 1043)	NC score	0.333838 (rank : 495)
Query Neighborhood Hits	534	Target Neighborhood Hits	869	Shared Neighborhood Hits	340
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK40_HUMAN
θ value	θ > 10 (rank : 1044)	NC score	0.390424 (rank : 112)
Query Neighborhood Hits	534	Target Neighborhood Hits	751	Shared Neighborhood Hits	338
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 1045)	NC score	0.389780 (rank : 118)
Query Neighborhood Hits	534	Target Neighborhood Hits	751	Shared Neighborhood Hits	338
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK4_HUMAN
θ value	θ > 10 (rank : 1046)	NC score	0.333088 (rank : 501)
Query Neighborhood Hits	534	Target Neighborhood Hits	870	Shared Neighborhood Hits	341
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 1047)	NC score	0.333222 (rank : 500)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	341
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STTP1_HUMAN
θ value	θ > 10 (rank : 1048)	NC score	0.138485 (rank : 1043)
Query Neighborhood Hits	534	Target Neighborhood Hits	232	Shared Neighborhood Hits	125
SwissProt Accessions	Q6IA86, Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0, Q9NV81	Gene names	STATIP1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1) (SHINC-2).

STYK1_HUMAN
θ value	θ > 10 (rank : 1049)	NC score	0.215389 (rank : 779)
Query Neighborhood Hits	534	Target Neighborhood Hits	786	Shared Neighborhood Hits	334
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1050)	NC score	0.199764 (rank : 876)
Query Neighborhood Hits	534	Target Neighborhood Hits	779	Shared Neighborhood Hits	328
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK1_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.314985 (rank : 545)
Query Neighborhood Hits	534	Target Neighborhood Hits	1734	Shared Neighborhood Hits	352
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.315208 (rank : 544)
Query Neighborhood Hits	534	Target Neighborhood Hits	1720	Shared Neighborhood Hits	352
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 1053)	NC score	0.327040 (rank : 531)
Query Neighborhood Hits	534	Target Neighborhood Hits	1172	Shared Neighborhood Hits	348
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 1054)	NC score	0.321833 (rank : 540)
Query Neighborhood Hits	534	Target Neighborhood Hits	1373	Shared Neighborhood Hits	349
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TBK1_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.358519 (rank : 386)
Query Neighborhood Hits	534	Target Neighborhood Hits	861	Shared Neighborhood Hits	336
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 1056)	NC score	0.358770 (rank : 382)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	334
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TEC_HUMAN
θ value	θ > 10 (rank : 1057)	NC score	0.235760 (rank : 662)
Query Neighborhood Hits	534	Target Neighborhood Hits	1006	Shared Neighborhood Hits	340
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 1058)	NC score	0.238447 (rank : 658)
Query Neighborhood Hits	534	Target Neighborhood Hits	1006	Shared Neighborhood Hits	340
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.304144 (rank : 552)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	337
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.304864 (rank : 551)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	336
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.296597 (rank : 559)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	339
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 1062)	NC score	0.296279 (rank : 560)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	340
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 1063)	NC score	0.116774 (rank : 1083)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	231
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1064)	NC score	0.146134 (rank : 1021)
Query Neighborhood Hits	534	Target Neighborhood Hits	1333	Shared Neighborhood Hits	269
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

THOC6_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.142205 (rank : 1033)
Query Neighborhood Hits	534	Target Neighborhood Hits	223	Shared Neighborhood Hits	124
SwissProt Accessions	Q86W42, Q8NBR1, Q9BTV9	Gene names	THOC6, WDR58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

THOC6_MOUSE
θ value	θ > 10 (rank : 1066)	NC score	0.132718 (rank : 1058)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	113
SwissProt Accessions	Q5U4D9	Gene names	Thoc6, Wdr58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

TIE1_HUMAN
θ value	θ > 10 (rank : 1067)	NC score	0.208151 (rank : 827)
Query Neighborhood Hits	534	Target Neighborhood Hits	1241	Shared Neighborhood Hits	337
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 1068)	NC score	0.209501 (rank : 820)
Query Neighborhood Hits	534	Target Neighborhood Hits	1266	Shared Neighborhood Hits	338
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 1069)	NC score	0.224199 (rank : 727)
Query Neighborhood Hits	534	Target Neighborhood Hits	1192	Shared Neighborhood Hits	342
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 1070)	NC score	0.223636 (rank : 730)
Query Neighborhood Hits	534	Target Neighborhood Hits	1204	Shared Neighborhood Hits	341
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TLE2_MOUSE
θ value	θ > 10 (rank : 1071)	NC score	0.141481 (rank : 1034)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	135
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

TLE3_HUMAN
θ value	θ > 10 (rank : 1072)	NC score	0.136841 (rank : 1050)
Query Neighborhood Hits	534	Target Neighborhood Hits	385	Shared Neighborhood Hits	134
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

TLE3_MOUSE
θ value	θ > 10 (rank : 1073)	NC score	0.137793 (rank : 1047)
Query Neighborhood Hits	534	Target Neighborhood Hits	378	Shared Neighborhood Hits	134
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

TLE6_HUMAN
θ value	θ > 10 (rank : 1074)	NC score	0.064022 (rank : 1159)
Query Neighborhood Hits	534	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H808	Gene names	TLE6
Domain Architecture	No domain graphic available
Description	Transducin-like enhancer protein 6.

TLE6_MOUSE
θ value	θ > 10 (rank : 1075)	NC score	0.090299 (rank : 1119)
Query Neighborhood Hits	534	Target Neighborhood Hits	178	Shared Neighborhood Hits	87
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

TLK1_HUMAN
θ value	θ > 10 (rank : 1076)	NC score	0.363039 (rank : 329)
Query Neighborhood Hits	534	Target Neighborhood Hits	967	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 1077)	NC score	0.363155 (rank : 325)
Query Neighborhood Hits	534	Target Neighborhood Hits	947	Shared Neighborhood Hits	342
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 1078)	NC score	0.361606 (rank : 347)
Query Neighborhood Hits	534	Target Neighborhood Hits	1044	Shared Neighborhood Hits	345
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 1079)	NC score	0.360744 (rank : 359)
Query Neighborhood Hits	534	Target Neighborhood Hits	1088	Shared Neighborhood Hits	345
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TNI3K_HUMAN
θ value	θ > 10 (rank : 1080)	NC score	0.239645 (rank : 657)
Query Neighborhood Hits	534	Target Neighborhood Hits	1084	Shared Neighborhood Hits	334
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 1081)	NC score	0.241996 (rank : 651)
Query Neighborhood Hits	534	Target Neighborhood Hits	1079	Shared Neighborhood Hits	330
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 1082)	NC score	0.220853 (rank : 744)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	339
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1083)	NC score	0.225607 (rank : 720)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	338
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 1084)	NC score	0.184082 (rank : 925)
Query Neighborhood Hits	534	Target Neighborhood Hits	605	Shared Neighborhood Hits	216
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1085)	NC score	0.195914 (rank : 891)
Query Neighborhood Hits	534	Target Neighborhood Hits	618	Shared Neighborhood Hits	232
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRAF7_HUMAN
θ value	θ > 10 (rank : 1086)	NC score	0.167145 (rank : 978)
Query Neighborhood Hits	534	Target Neighborhood Hits	482	Shared Neighborhood Hits	132
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRAF7_MOUSE
θ value	θ > 10 (rank : 1087)	NC score	0.168246 (rank : 975)
Query Neighborhood Hits	534	Target Neighborhood Hits	470	Shared Neighborhood Hits	134
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRIB1_HUMAN
θ value	θ > 10 (rank : 1088)	NC score	0.387810 (rank : 126)
Query Neighborhood Hits	534	Target Neighborhood Hits	598	Shared Neighborhood Hits	295
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 1089)	NC score	0.387217 (rank : 133)
Query Neighborhood Hits	534	Target Neighborhood Hits	593	Shared Neighborhood Hits	295
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 1090)	NC score	0.386091 (rank : 140)
Query Neighborhood Hits	534	Target Neighborhood Hits	657	Shared Neighborhood Hits	305
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 1091)	NC score	0.385705 (rank : 147)
Query Neighborhood Hits	534	Target Neighborhood Hits	653	Shared Neighborhood Hits	304
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 1092)	NC score	0.373844 (rank : 225)
Query Neighborhood Hits	534	Target Neighborhood Hits	519	Shared Neighborhood Hits	294
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 1093)	NC score	0.384860 (rank : 158)
Query Neighborhood Hits	534	Target Neighborhood Hits	578	Shared Neighborhood Hits	309
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 1094)	NC score	0.346678 (rank : 446)
Query Neighborhood Hits	534	Target Neighborhood Hits	1580	Shared Neighborhood Hits	347
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSCC1_MOUSE
θ value	θ > 10 (rank : 1095)	NC score	0.115818 (rank : 1085)
Query Neighborhood Hits	534	Target Neighborhood Hits	160	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K0G5	Gene names	Tssc1
Domain Architecture	No domain graphic available
Description	Protein TSSC1.

TSSC1_HUMAN
θ value	θ > 10 (rank : 1096)	NC score	0.115021 (rank : 1086)
Query Neighborhood Hits	534	Target Neighborhood Hits	157	Shared Neighborhood Hits	86
SwissProt Accessions	Q53HC9, O43179, Q53S19, Q53SG2	Gene names	TSSC1
Domain Architecture	No domain graphic available
Description	Protein TSSC1 (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) (Tumor-suppressing STF cDNA 1 protein).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1097)	NC score	0.385553 (rank : 149)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	342
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 1098)	NC score	0.385833 (rank : 146)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	342
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1099)	NC score	0.378156 (rank : 210)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	342
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 1100)	NC score	0.387304 (rank : 131)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	338
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 1101)	NC score	0.386708 (rank : 135)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	338
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTBK1_HUMAN
θ value	θ > 10 (rank : 1102)	NC score	0.292592 (rank : 568)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	331
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 1103)	NC score	0.290922 (rank : 574)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	325
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 1104)	NC score	0.289067 (rank : 580)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	325
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTK_HUMAN
θ value	θ > 10 (rank : 1105)	NC score	0.370718 (rank : 252)
Query Neighborhood Hits	534	Target Neighborhood Hits	816	Shared Neighborhood Hits	339
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 1106)	NC score	0.381095 (rank : 189)
Query Neighborhood Hits	534	Target Neighborhood Hits	803	Shared Neighborhood Hits	340
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TXK_HUMAN
θ value	θ > 10 (rank : 1107)	NC score	0.239759 (rank : 656)
Query Neighborhood Hits	534	Target Neighborhood Hits	971	Shared Neighborhood Hits	339
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 1108)	NC score	0.232162 (rank : 690)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	338
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 1109)	NC score	0.262614 (rank : 617)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	343
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1110)	NC score	0.257855 (rank : 623)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	343
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 1111)	NC score	0.200346 (rank : 873)
Query Neighborhood Hits	534	Target Neighborhood Hits	995	Shared Neighborhood Hits	326
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 1112)	NC score	0.200101 (rank : 875)
Query Neighborhood Hits	534	Target Neighborhood Hits	1007	Shared Neighborhood Hits	326
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 1113)	NC score	0.192649 (rank : 900)
Query Neighborhood Hits	534	Target Neighborhood Hits	981	Shared Neighborhood Hits	318
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 1114)	NC score	0.194091 (rank : 895)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	318
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ULK1_HUMAN
θ value	θ > 10 (rank : 1115)	NC score	0.361024 (rank : 356)
Query Neighborhood Hits	534	Target Neighborhood Hits	1121	Shared Neighborhood Hits	344
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 1116)	NC score	0.359681 (rank : 368)
Query Neighborhood Hits	534	Target Neighborhood Hits	1214	Shared Neighborhood Hits	346
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1117)	NC score	0.364701 (rank : 311)
Query Neighborhood Hits	534	Target Neighborhood Hits	979	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1118)	NC score	0.365035 (rank : 307)
Query Neighborhood Hits	534	Target Neighborhood Hits	943	Shared Neighborhood Hits	343
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 1119)	NC score	0.366688 (rank : 295)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 1120)	NC score	0.367773 (rank : 287)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 1121)	NC score	0.378882 (rank : 203)
Query Neighborhood Hits	534	Target Neighborhood Hits	793	Shared Neighborhood Hits	329
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

UTP18_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.090377 (rank : 1118)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y5J1, Q9H4N6	Gene names	UTP18, WDR50
Domain Architecture
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

UTP18_MOUSE
θ value	θ > 10 (rank : 1123)	NC score	0.076952 (rank : 1138)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	67
SwissProt Accessions	Q5SSI6	Gene names	Utp18, Wdr50
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

VGFR1_HUMAN
θ value	θ > 10 (rank : 1124)	NC score	0.183818 (rank : 928)
Query Neighborhood Hits	534	Target Neighborhood Hits	1109	Shared Neighborhood Hits	338
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 1125)	NC score	0.188034 (rank : 910)
Query Neighborhood Hits	534	Target Neighborhood Hits	1118	Shared Neighborhood Hits	340
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1126)	NC score	0.182068 (rank : 933)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	339
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1127)	NC score	0.183122 (rank : 931)
Query Neighborhood Hits	534	Target Neighborhood Hits	1089	Shared Neighborhood Hits	339
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1128)	NC score	0.185115 (rank : 920)
Query Neighborhood Hits	534	Target Neighborhood Hits	1037	Shared Neighborhood Hits	339
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1129)	NC score	0.187363 (rank : 912)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	339
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VRK1_HUMAN
θ value	θ > 10 (rank : 1130)	NC score	0.196596 (rank : 889)
Query Neighborhood Hits	534	Target Neighborhood Hits	584	Shared Neighborhood Hits	288
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 1131)	NC score	0.199723 (rank : 877)
Query Neighborhood Hits	534	Target Neighborhood Hits	583	Shared Neighborhood Hits	284
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
θ value	θ > 10 (rank : 1132)	NC score	0.195545 (rank : 892)
Query Neighborhood Hits	534	Target Neighborhood Hits	582	Shared Neighborhood Hits	278
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_MOUSE
θ value	θ > 10 (rank : 1133)	NC score	0.204848 (rank : 849)
Query Neighborhood Hits	534	Target Neighborhood Hits	586	Shared Neighborhood Hits	286
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK3_HUMAN
θ value	θ > 10 (rank : 1134)	NC score	0.123751 (rank : 1071)
Query Neighborhood Hits	534	Target Neighborhood Hits	349	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
θ value	θ > 10 (rank : 1135)	NC score	0.104969 (rank : 1108)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WD21A_HUMAN
θ value	θ > 10 (rank : 1136)	NC score	0.092455 (rank : 1115)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WV16, Q86U31, Q96K22, Q9Y4P5	Gene names	WDR21A, WDR21
Domain Architecture
Description	WD repeat protein 21A.

WD21C_HUMAN
θ value	θ > 10 (rank : 1137)	NC score	0.113341 (rank : 1091)
Query Neighborhood Hits	534	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NA75	Gene names	WDR21C
Domain Architecture	No domain graphic available
Description	WD repeat protein 21C.

WDFY2_HUMAN
θ value	θ > 10 (rank : 1138)	NC score	0.138468 (rank : 1044)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	137
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 1139)	NC score	0.138785 (rank : 1042)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY3_HUMAN
θ value	θ > 10 (rank : 1140)	NC score	0.077223 (rank : 1137)
Query Neighborhood Hits	534	Target Neighborhood Hits	348	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	θ > 10 (rank : 1141)	NC score	0.077866 (rank : 1136)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	109
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDHD1_HUMAN
θ value	θ > 10 (rank : 1142)	NC score	0.149717 (rank : 1013)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	129
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

WDHD1_MOUSE
θ value	θ > 10 (rank : 1143)	NC score	0.156319 (rank : 996)
Query Neighborhood Hits	534	Target Neighborhood Hits	414	Shared Neighborhood Hits	135
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

WDR12_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.200593 (rank : 872)
Query Neighborhood Hits	534	Target Neighborhood Hits	300	Shared Neighborhood Hits	146
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

WDR12_MOUSE
θ value	θ > 10 (rank : 1145)	NC score	0.201356 (rank : 867)
Query Neighborhood Hits	534	Target Neighborhood Hits	301	Shared Neighborhood Hits	147
SwissProt Accessions	Q9JJA4, Q9CST3, Q9JKF5	Gene names	Wdr12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

WDR13_HUMAN
θ value	θ > 10 (rank : 1146)	NC score	0.119837 (rank : 1079)
Query Neighborhood Hits	534	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H1Z4, Q9BUL7, Q9NWW4	Gene names	WDR13
Domain Architecture
Description	WD repeat protein 13.

WDR13_MOUSE
θ value	θ > 10 (rank : 1147)	NC score	0.115841 (rank : 1084)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	107
SwissProt Accessions	Q91V09	Gene names	Wdr13
Domain Architecture
Description	WD repeat protein 13.

WDR17_HUMAN
θ value	θ > 10 (rank : 1148)	NC score	0.191299 (rank : 902)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	142
SwissProt Accessions	Q8IZU2	Gene names	WDR17
Domain Architecture
Description	WD repeat protein 17.

WDR18_HUMAN
θ value	θ > 10 (rank : 1149)	NC score	0.170474 (rank : 973)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	130
SwissProt Accessions	Q9BV38, O60390, Q9BWR2	Gene names	WDR18
Domain Architecture
Description	WD repeat protein 18.

WDR18_MOUSE
θ value	θ > 10 (rank : 1150)	NC score	0.166903 (rank : 980)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	131
SwissProt Accessions	Q4VBE8	Gene names	Wdr18
Domain Architecture	No domain graphic available
Description	WD repeat protein 18.

WDR20_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.122335 (rank : 1073)
Query Neighborhood Hits	534	Target Neighborhood Hits	249	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TBZ3, Q8WXX2, Q9UF86	Gene names	WDR20
Domain Architecture
Description	WD repeat protein 20 (DMR protein).

WDR20_MOUSE
θ value	θ > 10 (rank : 1152)	NC score	0.123757 (rank : 1070)
Query Neighborhood Hits	534	Target Neighborhood Hits	217	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D5R2	Gene names	Wdr20
Domain Architecture
Description	WD repeat protein 20.

WDR23_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.178422 (rank : 942)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TEB1, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9	Gene names	WDR23
Domain Architecture
Description	WD repeat protein 23.

WDR23_MOUSE
θ value	θ > 10 (rank : 1154)	NC score	0.180890 (rank : 936)
Query Neighborhood Hits	534	Target Neighborhood Hits	271	Shared Neighborhood Hits	142
SwissProt Accessions	Q91VU6, Q3U836, Q8JZV8	Gene names	Wdr23, D14Ucla1
Domain Architecture
Description	WD repeat protein 23.

WDR24_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.145885 (rank : 1022)
Query Neighborhood Hits	534	Target Neighborhood Hits	247	Shared Neighborhood Hits	120
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

WDR26_HUMAN
θ value	θ > 10 (rank : 1156)	NC score	0.180835 (rank : 937)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	137
SwissProt Accessions	Q9H7D7, Q86UY4	Gene names	WDR26
Domain Architecture
Description	WD repeat protein 26.

WDR26_MOUSE
θ value	θ > 10 (rank : 1157)	NC score	0.180583 (rank : 939)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	137
SwissProt Accessions	Q8C6G8, Q8C4F3, Q8VDZ6	Gene names	Wdr26
Domain Architecture
Description	WD repeat protein 26.

WDR31_HUMAN
θ value	θ > 10 (rank : 1158)	NC score	0.199202 (rank : 878)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	139
SwissProt Accessions	Q8NA23, Q96EG8	Gene names	WDR31
Domain Architecture
Description	WD repeat protein 31.

WDR31_MOUSE
θ value	θ > 10 (rank : 1159)	NC score	0.194783 (rank : 893)
Query Neighborhood Hits	534	Target Neighborhood Hits	287	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JHB4, Q3URZ0, Q9D3N4	Gene names	Wdr31
Domain Architecture
Description	WD repeat protein 31 (Spermatid WD repeat protein) (spWD).

WDR3_HUMAN
θ value	θ > 10 (rank : 1160)	NC score	0.201763 (rank : 865)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UNX4	Gene names	WDR3
Domain Architecture
Description	WD repeat protein 3.

WDR41_HUMAN
θ value	θ > 10 (rank : 1161)	NC score	0.121231 (rank : 1074)
Query Neighborhood Hits	534	Target Neighborhood Hits	208	Shared Neighborhood Hits	112
SwissProt Accessions	Q9HAD4, Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62	Gene names	WDR41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

WDR41_MOUSE
θ value	θ > 10 (rank : 1162)	NC score	0.136082 (rank : 1055)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	114
SwissProt Accessions	Q3UDP0, Q8C4F1, Q8C8K5	Gene names	Wdr41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

WDR43_HUMAN
θ value	θ > 10 (rank : 1163)	NC score	0.156415 (rank : 995)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	108
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

WDR46_HUMAN
θ value	θ > 10 (rank : 1164)	NC score	0.090605 (rank : 1117)
Query Neighborhood Hits	534	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

WDR46_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.082028 (rank : 1128)
Query Neighborhood Hits	534	Target Neighborhood Hits	243	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

WDR49_HUMAN
θ value	θ > 10 (rank : 1166)	NC score	0.165215 (rank : 983)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IV35, Q8N297	Gene names	WDR49
Domain Architecture	No domain graphic available
Description	WD repeat protein 49.

WDR4_MOUSE
θ value	θ > 10 (rank : 1167)	NC score	0.100656 (rank : 1110)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	85
SwissProt Accessions	Q9EP82	Gene names	Wdr4
Domain Architecture
Description	WD repeat protein 4.

WDR53_HUMAN
θ value	θ > 10 (rank : 1168)	NC score	0.168067 (rank : 977)
Query Neighborhood Hits	534	Target Neighborhood Hits	251	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z5U6	Gene names	WDR53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

WDR55_HUMAN
θ value	θ > 10 (rank : 1169)	NC score	0.152618 (rank : 1005)
Query Neighborhood Hits	534	Target Neighborhood Hits	231	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6Y2	Gene names	WDR55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

WDR55_MOUSE
θ value	θ > 10 (rank : 1170)	NC score	0.155793 (rank : 999)
Query Neighborhood Hits	534	Target Neighborhood Hits	236	Shared Neighborhood Hits	113
SwissProt Accessions	Q9CX97	Gene names	Wdr55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

WDR65_HUMAN
θ value	θ > 10 (rank : 1171)	NC score	0.163046 (rank : 985)
Query Neighborhood Hits	534	Target Neighborhood Hits	238	Shared Neighborhood Hits	124
SwissProt Accessions	Q96MR6, Q5TAI0	Gene names	WDR65
Domain Architecture	No domain graphic available
Description	WD repeat protein 65.

WDR67_HUMAN
θ value	θ > 10 (rank : 1172)	NC score	0.066241 (rank : 1155)
Query Neighborhood Hits	534	Target Neighborhood Hits	782	Shared Neighborhood Hits	110
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

WDR67_MOUSE
θ value	θ > 10 (rank : 1173)	NC score	0.074713 (rank : 1143)
Query Neighborhood Hits	534	Target Neighborhood Hits	476	Shared Neighborhood Hits	91
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

WDR68_HUMAN
θ value	θ > 10 (rank : 1174)	NC score	0.077892 (rank : 1134)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	P61962, O15491, Q9DAE4	Gene names	WDR68, HAN11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR68_MOUSE
θ value	θ > 10 (rank : 1175)	NC score	0.077892 (rank : 1135)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	P61963, O15491, Q3TMV9, Q9DAE4	Gene names	Wdr68, Han11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR69_HUMAN
θ value	θ > 10 (rank : 1176)	NC score	0.206865 (rank : 836)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	142
SwissProt Accessions	Q8N136, Q6ZRY1, Q8N776	Gene names	WDR69
Domain Architecture	No domain graphic available
Description	WD repeat protein 69.

WDR71_HUMAN
θ value	θ > 10 (rank : 1177)	NC score	0.188401 (rank : 907)
Query Neighborhood Hits	534	Target Neighborhood Hits	241	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BRP4, Q4G165, Q53HS9, Q7Z500, Q8TBU6, Q9HAB6	Gene names	WDR71
Domain Architecture	No domain graphic available
Description	WD repeat protein 71 (Protein G-16).

WDR72_HUMAN
θ value	θ > 10 (rank : 1178)	NC score	0.082675 (rank : 1127)
Query Neighborhood Hits	534	Target Neighborhood Hits	167	Shared Neighborhood Hits	86
SwissProt Accessions	Q3MJ13, Q7Z3I3, Q8N8X2	Gene names	WDR72
Domain Architecture	No domain graphic available
Description	WD repeat protein 72.

WDR74_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.061429 (rank : 1162)
Query Neighborhood Hits	534	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2	Gene names	WDR74, NSA1
Domain Architecture	No domain graphic available
Description	WD repeat protein 74 (NOP seven-associated protein 1).

WDR7_HUMAN
θ value	θ > 10 (rank : 1180)	NC score	0.105565 (rank : 1106)
Query Neighborhood Hits	534	Target Neighborhood Hits	244	Shared Neighborhood Hits	117
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

WDR7_MOUSE
θ value	θ > 10 (rank : 1181)	NC score	0.109131 (rank : 1100)
Query Neighborhood Hits	534	Target Neighborhood Hits	226	Shared Neighborhood Hits	116
SwissProt Accessions	Q920I9, Q80TY3, Q920J0	Gene names	Wdr7, Kiaa0541, Trag
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG).

WDR81_HUMAN
θ value	θ > 10 (rank : 1182)	NC score	0.106128 (rank : 1103)
Query Neighborhood Hits	534	Target Neighborhood Hits	205	Shared Neighborhood Hits	98
SwissProt Accessions	Q562E7, Q24JP6, Q8N277, Q8N3F3	Gene names	WDR81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

WDR85_HUMAN
θ value	θ > 10 (rank : 1183)	NC score	0.076541 (rank : 1140)
Query Neighborhood Hits	534	Target Neighborhood Hits	134	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BTV6, Q96AB7	Gene names	WDR85, C9orf112
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

WDR85_MOUSE
θ value	θ > 10 (rank : 1184)	NC score	0.052952 (rank : 1168)
Query Neighborhood Hits	534	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q9CYU6, Q5RJV7, Q8BIT9	Gene names	Wdr85
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

WDTC1_HUMAN
θ value	θ > 10 (rank : 1185)	NC score	0.139640 (rank : 1040)
Query Neighborhood Hits	534	Target Neighborhood Hits	299	Shared Neighborhood Hits	133
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDTC1_MOUSE
θ value	θ > 10 (rank : 1186)	NC score	0.139126 (rank : 1041)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	134
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WEE1B_HUMAN
θ value	θ > 10 (rank : 1187)	NC score	0.321759 (rank : 541)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	328
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	θ > 10 (rank : 1188)	NC score	0.324685 (rank : 535)
Query Neighborhood Hits	534	Target Neighborhood Hits	765	Shared Neighborhood Hits	328
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
θ value	θ > 10 (rank : 1189)	NC score	0.324632 (rank : 536)
Query Neighborhood Hits	534	Target Neighborhood Hits	777	Shared Neighborhood Hits	325
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 1190)	NC score	0.329627 (rank : 515)
Query Neighborhood Hits	534	Target Neighborhood Hits	794	Shared Neighborhood Hits	329
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WNK1_HUMAN
θ value	θ > 10 (rank : 1191)	NC score	0.327879 (rank : 525)
Query Neighborhood Hits	534	Target Neighborhood Hits	1158	Shared Neighborhood Hits	339
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 1192)	NC score	0.327860 (rank : 526)
Query Neighborhood Hits	534	Target Neighborhood Hits	1179	Shared Neighborhood Hits	342
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK3_HUMAN
θ value	θ > 10 (rank : 1193)	NC score	0.338783 (rank : 477)
Query Neighborhood Hits	534	Target Neighborhood Hits	948	Shared Neighborhood Hits	341
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 1194)	NC score	0.331211 (rank : 510)
Query Neighborhood Hits	534	Target Neighborhood Hits	1043	Shared Neighborhood Hits	333
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	θ > 10 (rank : 1195)	NC score	0.333350 (rank : 499)
Query Neighborhood Hits	534	Target Neighborhood Hits	961	Shared Neighborhood Hits	339
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WSB2_HUMAN
θ value	θ > 10 (rank : 1196)	NC score	0.201611 (rank : 866)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

WSB2_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.198700 (rank : 881)
Query Neighborhood Hits	534	Target Neighborhood Hits	306	Shared Neighborhood Hits	145
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

YES_HUMAN
θ value	θ > 10 (rank : 1198)	NC score	0.215314 (rank : 780)
Query Neighborhood Hits	534	Target Neighborhood Hits	1059	Shared Neighborhood Hits	341
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 1199)	NC score	0.214928 (rank : 782)
Query Neighborhood Hits	534	Target Neighborhood Hits	1052	Shared Neighborhood Hits	341
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 1200)	NC score	0.337811 (rank : 478)
Query Neighborhood Hits	534	Target Neighborhood Hits	921	Shared Neighborhood Hits	343
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 1201)	NC score	0.230140 (rank : 703)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	337
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 1202)	NC score	0.230109 (rank : 704)
Query Neighborhood Hits	534	Target Neighborhood Hits	905	Shared Neighborhood Hits	341
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZF106_MOUSE
θ value	θ > 10 (rank : 1203)	NC score	0.128197 (rank : 1062)
Query Neighborhood Hits	534	Target Neighborhood Hits	472	Shared Neighborhood Hits	113
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

Hits sorted by NC score

PI3R4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	534	Target Neighborhood Hits	534	Shared Neighborhood Hits	534
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
NC score	0.985984 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	534	Target Neighborhood Hits	535	Shared Neighborhood Hits	490
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PHKG2_HUMAN
NC score	0.414900 (rank : 3)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG1_HUMAN
NC score	0.414652 (rank : 4)	θ value	0.000786445 (rank : 41)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

MELK_HUMAN
NC score	0.413670 (rank : 5)	θ value	4.92598e-06 (rank : 6)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

PHKG1_MOUSE
NC score	0.412986 (rank : 6)	θ value	0.0148317 (rank : 106)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	344
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_MOUSE
NC score	0.411735 (rank : 7)	θ value	0.00390308 (rank : 75)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

CHK2_MOUSE
NC score	0.411729 (rank : 8)	θ value	0.00035302 (rank : 25)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	343
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

MELK_MOUSE
NC score	0.410618 (rank : 9)	θ value	0.000158464 (rank : 21)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	345
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

PIM3_MOUSE
NC score	0.410526 (rank : 10)	θ value	0.0431538 (rank : 140)
Query Neighborhood Hits	534	Target Neighborhood Hits	783	Shared Neighborhood Hits	332
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM1_MOUSE
NC score	0.410398 (rank : 11)	θ value	0.00665767 (rank : 84)
Query Neighborhood Hits	534	Target Neighborhood Hits	787	Shared Neighborhood Hits	336
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

CHK2_HUMAN
NC score	0.409535 (rank : 12)	θ value	0.00665767 (rank : 82)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	345
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

SN1L1_MOUSE
NC score	0.409033 (rank : 13)	θ value	1.43324e-05 (rank : 11)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	344
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

NUAK2_MOUSE
NC score	0.408919 (rank : 14)	θ value	6.43352e-06 (rank : 9)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

TSSK3_HUMAN
NC score	0.408820 (rank : 15)	θ value	0.0148317 (rank : 108)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	341
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
NC score	0.408693 (rank : 16)	θ value	0.0563607 (rank : 159)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	341
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

PIM3_HUMAN
NC score	0.408414 (rank : 17)	θ value	0.0431538 (rank : 139)
Query Neighborhood Hits	534	Target Neighborhood Hits	789	Shared Neighborhood Hits	334
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM1_HUMAN
NC score	0.407716 (rank : 18)	θ value	0.0330416 (rank : 128)
Query Neighborhood Hits	534	Target Neighborhood Hits	797	Shared Neighborhood Hits	336
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MKNK2_HUMAN
NC score	0.407524 (rank : 19)	θ value	0.0736092 (rank : 168)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	343
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KCC1B_HUMAN
NC score	0.407129 (rank : 20)	θ value	0.000461057 (rank : 31)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

NUAK1_MOUSE
NC score	0.407013 (rank : 21)	θ value	9.92553e-07 (rank : 3)
Query Neighborhood Hits	534	Target Neighborhood Hits	881	Shared Neighborhood Hits	344
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

KCC1B_MOUSE
NC score	0.406279 (rank : 22)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

SN1L1_HUMAN
NC score	0.405977 (rank : 23)	θ value	0.000270298 (rank : 24)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	344
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

NUAK1_HUMAN
NC score	0.405508 (rank : 24)	θ value	4.92598e-06 (rank : 7)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	345
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

KCC2A_MOUSE
NC score	0.405353 (rank : 25)	θ value	0.0431538 (rank : 133)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	344
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.405193 (rank : 26)	θ value	0.163984 (rank : 205)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	344
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

NIM1_MOUSE
NC score	0.405128 (rank : 27)	θ value	0.000602161 (rank : 39)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KCC2A_HUMAN
NC score	0.405030 (rank : 28)	θ value	0.0431538 (rank : 132)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

PASK_MOUSE
NC score	0.404961 (rank : 29)	θ value	0.0431538 (rank : 138)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	345
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KCC2B_MOUSE
NC score	0.404946 (rank : 30)	θ value	0.163984 (rank : 206)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	345
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
NC score	0.404924 (rank : 31)	θ value	0.0563607 (rank : 149)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	344
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

AAPK2_HUMAN
NC score	0.404653 (rank : 32)	θ value	0.00020696 (rank : 23)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

PIM2_MOUSE
NC score	0.404246 (rank : 33)	θ value	0.163984 (rank : 215)
Query Neighborhood Hits	534	Target Neighborhood Hits	809	Shared Neighborhood Hits	338
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

SN1L2_MOUSE
NC score	0.404080 (rank : 34)	θ value	7.1131e-05 (rank : 16)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	345
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

NUAK2_HUMAN
NC score	0.404062 (rank : 35)	θ value	4.92598e-06 (rank : 8)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PIM2_HUMAN
NC score	0.403927 (rank : 36)	θ value	0.163984 (rank : 214)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	341
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

MKNK2_MOUSE
NC score	0.403868 (rank : 37)	θ value	0.279714 (rank : 250)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	343
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KCC1A_HUMAN
NC score	0.403780 (rank : 38)	θ value	0.00175202 (rank : 52)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC4_MOUSE
NC score	0.403752 (rank : 39)	θ value	0.0736092 (rank : 164)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1A_MOUSE
NC score	0.403721 (rank : 40)	θ value	0.00175202 (rank : 53)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	344
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1D_MOUSE
NC score	0.403690 (rank : 41)	θ value	0.00175202 (rank : 55)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.403660 (rank : 42)	θ value	0.00175202 (rank : 54)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	343
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

NIM1_HUMAN
NC score	0.403588 (rank : 43)	θ value	0.00175202 (rank : 59)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PDPK1_MOUSE
NC score	0.403441 (rank : 44)	θ value	3.19293e-05 (rank : 12)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.402919 (rank : 45)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

KS6A4_HUMAN
NC score	0.402848 (rank : 46)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	534	Target Neighborhood Hits	868	Shared Neighborhood Hits	344
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

AAPK1_MOUSE
NC score	0.402727 (rank : 47)	θ value	0.000461057 (rank : 28)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_HUMAN
NC score	0.402636 (rank : 48)	θ value	0.000461057 (rank : 27)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

SN1L2_HUMAN
NC score	0.402540 (rank : 49)	θ value	0.000461057 (rank : 34)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	346
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

KCC1G_MOUSE
NC score	0.402128 (rank : 50)	θ value	0.00175202 (rank : 56)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MKNK1_MOUSE
NC score	0.401902 (rank : 51)	θ value	0.279714 (rank : 249)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	341
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

SNRK_MOUSE
NC score	0.401834 (rank : 52)	θ value	0.813845 (rank : 342)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_HUMAN
NC score	0.401624 (rank : 53)	θ value	0.62314 (rank : 321)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	343
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KS6A4_MOUSE
NC score	0.401513 (rank : 54)	θ value	0.000602161 (rank : 37)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KCC1G_HUMAN
NC score	0.401157 (rank : 55)	θ value	0.00509761 (rank : 78)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	343
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC4_HUMAN
NC score	0.401067 (rank : 56)	θ value	0.279714 (rank : 242)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

F5006_HUMAN
NC score	0.400953 (rank : 57)	θ value	2.36792 (rank : 408)
Query Neighborhood Hits	534	Target Neighborhood Hits	794	Shared Neighborhood Hits	339
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KCC2G_HUMAN
NC score	0.400893 (rank : 58)	θ value	0.163984 (rank : 207)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	344
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
NC score	0.400870 (rank : 59)	θ value	0.163984 (rank : 208)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

K0999_HUMAN
NC score	0.400534 (rank : 60)	θ value	0.0113563 (rank : 101)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

HUNK_MOUSE
NC score	0.399747 (rank : 61)	θ value	0.00175202 (rank : 51)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

K0999_MOUSE
NC score	0.399722 (rank : 62)	θ value	0.0252991 (rank : 113)
Query Neighborhood Hits	534	Target Neighborhood Hits	931	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

CAMKV_MOUSE
NC score	0.399418 (rank : 63)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	333
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

KS6A5_HUMAN
NC score	0.399157 (rank : 64)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	344
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

BRSK1_HUMAN
NC score	0.399157 (rank : 65)	θ value	0.0563607 (rank : 144)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	344
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

HUNK_HUMAN
NC score	0.399034 (rank : 66)	θ value	0.00298849 (rank : 66)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	345
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

CSK22_HUMAN
NC score	0.398902 (rank : 67)	θ value	0.0563607 (rank : 145)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	337
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
NC score	0.398839 (rank : 68)	θ value	0.0563607 (rank : 146)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	337
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

MARK1_MOUSE
NC score	0.398199 (rank : 69)	θ value	0.00298849 (rank : 67)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	344
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

BRSK2_HUMAN
NC score	0.398129 (rank : 70)	θ value	0.163984 (rank : 197)
Query Neighborhood Hits	534	Target Neighborhood Hits	897	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MARK1_HUMAN
NC score	0.397718 (rank : 71)	θ value	0.00390308 (rank : 74)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	344
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK2_HUMAN
NC score	0.397698 (rank : 72)	θ value	0.00298849 (rank : 68)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	347
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

KS6A5_MOUSE
NC score	0.397244 (rank : 73)	θ value	0.00390308 (rank : 73)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MARK2_MOUSE
NC score	0.397096 (rank : 74)	θ value	0.0252991 (rank : 117)
Query Neighborhood Hits	534	Target Neighborhood Hits	1018	Shared Neighborhood Hits	346
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

CSK21_HUMAN
NC score	0.396787 (rank : 75)	θ value	0.125558 (rank : 185)
Query Neighborhood Hits	534	Target Neighborhood Hits	772	Shared Neighborhood Hits	336
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

F5006_MOUSE
NC score	0.396632 (rank : 76)	θ value	3.0926 (rank : 426)
Query Neighborhood Hits	534	Target Neighborhood Hits	793	Shared Neighborhood Hits	337
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KPSH1_HUMAN
NC score	0.396630 (rank : 77)	θ value	0.813845 (rank : 332)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

TSSK1_HUMAN
NC score	0.396605 (rank : 78)	θ value	0.62314 (rank : 324)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDKL5_HUMAN
NC score	0.396599 (rank : 79)	θ value	3.77169e-06 (rank : 5)
Query Neighborhood Hits	534	Target Neighborhood Hits	967	Shared Neighborhood Hits	345
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MAPK5_MOUSE
NC score	0.396476 (rank : 80)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	337
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MKNK1_HUMAN
NC score	0.396473 (rank : 81)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	534	Target Neighborhood Hits	701	Shared Neighborhood Hits	333
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

KPSH1_MOUSE
NC score	0.396455 (rank : 82)	θ value	0.813845 (rank : 333)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

CAMKV_HUMAN
NC score	0.396395 (rank : 83)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	534	Target Neighborhood Hits	1084	Shared Neighborhood Hits	334
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MARK3_MOUSE
NC score	0.396376 (rank : 84)	θ value	0.00665767 (rank : 83)
Query Neighborhood Hits	534	Target Neighborhood Hits	919	Shared Neighborhood Hits	346
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MAPK5_HUMAN
NC score	0.396256 (rank : 85)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	534	Target Neighborhood Hits	795	Shared Neighborhood Hits	337
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

CSK21_MOUSE
NC score	0.396230 (rank : 86)	θ value	0.125558 (rank : 186)
Query Neighborhood Hits	534	Target Neighborhood Hits	770	Shared Neighborhood Hits	336
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

AKT3_MOUSE
NC score	0.396106 (rank : 87)	θ value	0.000461057 (rank : 30)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT3_HUMAN
NC score	0.396085 (rank : 88)	θ value	0.000461057 (rank : 29)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

SGK2_HUMAN
NC score	0.394480 (rank : 89)	θ value	0.00869519 (rank : 100)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	344
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MARK4_HUMAN
NC score	0.394236 (rank : 90)	θ value	0.0736092 (rank : 166)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	346
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.394145 (rank : 91)	θ value	0.0736092 (rank : 167)
Query Neighborhood Hits	534	Target Neighborhood Hits	898	Shared Neighborhood Hits	344
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

CDKL1_MOUSE
NC score	0.394017 (rank : 92)	θ value	0.000602161 (rank : 35)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

SGK2_MOUSE
NC score	0.393980 (rank : 93)	θ value	0.00665767 (rank : 86)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	344
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDKL1_HUMAN
NC score	0.393942 (rank : 94)	θ value	0.000786445 (rank : 40)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CHK1_MOUSE
NC score	0.393511 (rank : 95)	θ value	0.47712 (rank : 284)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

PASK_HUMAN
NC score	0.393498 (rank : 96)	θ value	4.03905 (rank : 452)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	343
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

SGK1_MOUSE
NC score	0.393272 (rank : 97)	θ value	0.00175202 (rank : 60)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_HUMAN
NC score	0.393196 (rank : 98)	θ value	0.00102713 (rank : 48)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AKT1_MOUSE
NC score	0.392986 (rank : 99)	θ value	0.00390308 (rank : 70)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	342
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CHK1_HUMAN
NC score	0.392540 (rank : 100)	θ value	0.47712 (rank : 283)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

AKT1_HUMAN
NC score	0.392451 (rank : 101)	θ value	0.00390308 (rank : 69)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	342
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT2_HUMAN
NC score	0.392184 (rank : 102)	θ value	0.00869519 (rank : 91)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	344
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KAPCB_MOUSE
NC score	0.392124 (rank : 103)	θ value	0.0113563 (rank : 102)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

AKT2_MOUSE
NC score	0.392051 (rank : 104)	θ value	0.00869519 (rank : 92)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	344
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

DCAK3_HUMAN
NC score	0.391898 (rank : 105)	θ value	8.99809 (rank : 515)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	345
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KAPCB_HUMAN
NC score	0.391724 (rank : 106)	θ value	0.0148317 (rank : 104)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

MAST1_MOUSE
NC score	0.391721 (rank : 107)	θ value	0.00869519 (rank : 97)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	345
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KS6B2_HUMAN
NC score	0.391495 (rank : 108)	θ value	0.21417 (rank : 226)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

MAST1_HUMAN
NC score	0.391394 (rank : 109)	θ value	0.00869519 (rank : 96)
Query Neighborhood Hits	534	Target Neighborhood Hits	1146	Shared Neighborhood Hits	347
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

TSSK1_MOUSE
NC score	0.390567 (rank : 110)	θ value	1.06291 (rank : 359)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	344
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KS6B2_MOUSE
NC score	0.390523 (rank : 111)	θ value	0.47712 (rank : 289)
Query Neighborhood Hits	534	Target Neighborhood Hits	871	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

STK40_HUMAN
NC score	0.390424 (rank : 112)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	534	Target Neighborhood Hits	751	Shared Neighborhood Hits	338
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

KAPCA_HUMAN
NC score	0.390380 (rank : 113)	θ value	0.0961366 (rank : 173)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MK15_MOUSE
NC score	0.390205 (rank : 114)	θ value	0.000602161 (rank : 38)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

DCAK3_MOUSE
NC score	0.390031 (rank : 115)	θ value	8.99809 (rank : 516)
Query Neighborhood Hits	534	Target Neighborhood Hits	922	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

MAST2_MOUSE
NC score	0.389977 (rank : 116)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	534	Target Neighborhood Hits	1110	Shared Neighborhood Hits	347
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KAPCA_MOUSE
NC score	0.389969 (rank : 117)	θ value	0.0961366 (rank : 174)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

STK40_MOUSE
NC score	0.389780 (rank : 118)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	534	Target Neighborhood Hits	751	Shared Neighborhood Hits	338
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

MAST2_HUMAN
NC score	0.389369 (rank : 119)	θ value	0.0330416 (rank : 126)
Query Neighborhood Hits	534	Target Neighborhood Hits	1189	Shared Neighborhood Hits	347
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.389201 (rank : 120)	θ value	0.0563607 (rank : 150)
Query Neighborhood Hits	534	Target Neighborhood Hits	1128	Shared Neighborhood Hits	345
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

DMPK_MOUSE
NC score	0.389196 (rank : 121)	θ value	0.163984 (rank : 200)
Query Neighborhood Hits	534	Target Neighborhood Hits	908	Shared Neighborhood Hits	342
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KPCI_MOUSE
NC score	0.389034 (rank : 122)	θ value	0.125558 (rank : 188)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	344
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.388827 (rank : 123)	θ value	0.125558 (rank : 187)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	344
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

DMPK_HUMAN
NC score	0.388769 (rank : 124)	θ value	0.163984 (rank : 199)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	344
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

SGK3_HUMAN
NC score	0.388033 (rank : 125)	θ value	0.0431538 (rank : 141)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	344
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

TRIB1_HUMAN
NC score	0.387810 (rank : 126)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	534	Target Neighborhood Hits	598	Shared Neighborhood Hits	295
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

CDKL3_MOUSE
NC score	0.387806 (rank : 127)	θ value	0.00869519 (rank : 94)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

SGK3_MOUSE
NC score	0.387502 (rank : 128)	θ value	0.0252991 (rank : 120)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

MARK3_HUMAN
NC score	0.387404 (rank : 129)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	343
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

ST38L_MOUSE
NC score	0.387327 (rank : 130)	θ value	0.47712 (rank : 300)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	336
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TSSK6_HUMAN
NC score	0.387304 (rank : 131)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	338
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ST38L_HUMAN
NC score	0.387231 (rank : 132)	θ value	0.365318 (rank : 275)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	339
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TRIB1_MOUSE
NC score	0.387217 (rank : 133)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	534	Target Neighborhood Hits	593	Shared Neighborhood Hits	295
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

CDKL3_HUMAN
NC score	0.387100 (rank : 134)	θ value	0.00509761 (rank : 77)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

TSSK6_MOUSE
NC score	0.386708 (rank : 135)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	338
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PRKX_MOUSE
NC score	0.386441 (rank : 136)	θ value	0.365318 (rank : 273)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KPCZ_MOUSE
NC score	0.386219 (rank : 137)	θ value	0.365318 (rank : 262)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	343
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.386125 (rank : 138)	θ value	0.365318 (rank : 261)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	343
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

PRKX_HUMAN
NC score	0.386112 (rank : 139)	θ value	0.279714 (rank : 252)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	344
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

TRIB2_HUMAN
NC score	0.386091 (rank : 140)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	534	Target Neighborhood Hits	657	Shared Neighborhood Hits	305
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

PLK4_HUMAN
NC score	0.386038 (rank : 141)	θ value	0.0736092 (rank : 170)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	344
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

LATS1_MOUSE
NC score	0.385961 (rank : 142)	θ value	0.0736092 (rank : 165)
Query Neighborhood Hits	534	Target Neighborhood Hits	1027	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

STK38_HUMAN
NC score	0.385934 (rank : 143)	θ value	0.365318 (rank : 277)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

MAPK3_HUMAN
NC score	0.385862 (rank : 144)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	338
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

STK38_MOUSE
NC score	0.385844 (rank : 145)	θ value	0.365318 (rank : 278)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TSSK2_MOUSE
NC score	0.385833 (rank : 146)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	342
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TRIB2_MOUSE
NC score	0.385705 (rank : 147)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	534	Target Neighborhood Hits	653	Shared Neighborhood Hits	304
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

CDKL2_MOUSE
NC score	0.385687 (rank : 148)	θ value	0.00228821 (rank : 61)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	343
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

TSSK2_HUMAN
NC score	0.385553 (rank : 149)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	342
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

KAPCG_HUMAN
NC score	0.385525 (rank : 150)	θ value	0.62314 (rank : 309)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	343
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

STK33_HUMAN
NC score	0.385390 (rank : 151)	θ value	0.365318 (rank : 276)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	344
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

TSSK4_HUMAN
NC score	0.385236 (rank : 152)	θ value	0.813845 (rank : 343)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	344
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

PLK4_MOUSE
NC score	0.385217 (rank : 153)	θ value	0.125558 (rank : 191)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	346
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

CDKL2_HUMAN
NC score	0.385010 (rank : 154)	θ value	0.00298849 (rank : 65)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	343
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

KS6B1_HUMAN
NC score	0.384932 (rank : 155)	θ value	1.38821 (rank : 369)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.384896 (rank : 156)	θ value	1.38821 (rank : 370)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

AURKB_MOUSE
NC score	0.384882 (rank : 157)	θ value	1.38821 (rank : 362)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

TRIB3_MOUSE
NC score	0.384860 (rank : 158)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	534	Target Neighborhood Hits	578	Shared Neighborhood Hits	309
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

MAPK3_MOUSE
NC score	0.384810 (rank : 159)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	338
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MOK_HUMAN
NC score	0.384696 (rank : 160)	θ value	0.00102713 (rank : 45)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	341
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MAPK2_MOUSE
NC score	0.384622 (rank : 161)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	337
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_HUMAN
NC score	0.384290 (rank : 162)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	337
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MOK_MOUSE
NC score	0.384236 (rank : 163)	θ value	0.00175202 (rank : 58)
Query Neighborhood Hits	534	Target Neighborhood Hits	796	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

AURKC_HUMAN
NC score	0.383837 (rank : 164)	θ value	0.21417 (rank : 221)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	345
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

KS6A1_MOUSE
NC score	0.383650 (rank : 165)	θ value	0.365318 (rank : 263)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	344
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KPSH2_HUMAN
NC score	0.383630 (rank : 166)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	339
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KPCD1_MOUSE
NC score	0.383599 (rank : 167)	θ value	0.279714 (rank : 244)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	343
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

STK11_HUMAN
NC score	0.383589 (rank : 168)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	342
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

M3K4_HUMAN
NC score	0.383511 (rank : 169)	θ value	0.000461057 (rank : 32)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	346
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

LATS1_HUMAN
NC score	0.383473 (rank : 170)	θ value	0.279714 (rank : 248)
Query Neighborhood Hits	534	Target Neighborhood Hits	1057	Shared Neighborhood Hits	345
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS2_MOUSE
NC score	0.383087 (rank : 171)	θ value	0.47712 (rank : 293)
Query Neighborhood Hits	534	Target Neighborhood Hits	879	Shared Neighborhood Hits	341
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

AURKC_MOUSE
NC score	0.383084 (rank : 172)	θ value	0.365318 (rank : 257)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

KPCD3_MOUSE
NC score	0.382920 (rank : 173)	θ value	0.163984 (rank : 209)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCL_MOUSE
NC score	0.382794 (rank : 174)	θ value	0.163984 (rank : 210)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	343
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

M3K4_MOUSE
NC score	0.382768 (rank : 175)	θ value	0.000461057 (rank : 33)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	347
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

PRKY_HUMAN
NC score	0.382699 (rank : 176)	θ value	1.81305 (rank : 394)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

DAPK3_MOUSE
NC score	0.382582 (rank : 177)	θ value	1.06291 (rank : 347)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	342
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

LATS2_HUMAN
NC score	0.382487 (rank : 178)	θ value	0.47712 (rank : 292)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	341
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

KS6A6_HUMAN
NC score	0.382324 (rank : 179)	θ value	0.163984 (rank : 211)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KPCL_HUMAN
NC score	0.382314 (rank : 180)	θ value	0.279714 (rank : 245)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	343
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

CDKL4_MOUSE
NC score	0.382296 (rank : 181)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MAST4_HUMAN
NC score	0.382033 (rank : 182)	θ value	0.0563607 (rank : 151)
Query Neighborhood Hits	534	Target Neighborhood Hits	1804	Shared Neighborhood Hits	359
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

DAPK2_HUMAN
NC score	0.381927 (rank : 183)	θ value	2.36792 (rank : 405)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CDKL4_HUMAN
NC score	0.381856 (rank : 184)	θ value	0.0252991 (rank : 112)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	342
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KPCD2_HUMAN
NC score	0.381704 (rank : 185)	θ value	0.62314 (rank : 310)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	343
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD3_HUMAN
NC score	0.381677 (rank : 186)	θ value	0.21417 (rank : 224)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	342
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD1_HUMAN
NC score	0.381632 (rank : 187)	θ value	0.813845 (rank : 330)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	343
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

DCAK2_HUMAN
NC score	0.381267 (rank : 188)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	342
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

TTK_MOUSE
NC score	0.381095 (rank : 189)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	534	Target Neighborhood Hits	803	Shared Neighborhood Hits	340
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

DAPK3_HUMAN
NC score	0.381057 (rank : 190)	θ value	3.0926 (rank : 424)
Query Neighborhood Hits	534	Target Neighborhood Hits	945	Shared Neighborhood Hits	343
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

AURKB_HUMAN
NC score	0.381023 (rank : 191)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	343
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

DAPK2_MOUSE
NC score	0.381008 (rank : 192)	θ value	2.36792 (rank : 406)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MASTL_HUMAN
NC score	0.381002 (rank : 193)	θ value	0.0563607 (rank : 152)
Query Neighborhood Hits	534	Target Neighborhood Hits	894	Shared Neighborhood Hits	343
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

DCAK2_MOUSE
NC score	0.380396 (rank : 194)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

MASTL_MOUSE
NC score	0.380036 (rank : 195)	θ value	0.0563607 (rank : 153)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	344
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

DCAK1_HUMAN
NC score	0.379812 (rank : 196)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	343
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
NC score	0.379639 (rank : 197)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KS6A3_HUMAN
NC score	0.379524 (rank : 198)	θ value	0.125558 (rank : 189)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	344
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
NC score	0.379473 (rank : 199)	θ value	0.125558 (rank : 190)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	344
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A2_MOUSE
NC score	0.379361 (rank : 200)	θ value	0.365318 (rank : 264)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A2_HUMAN
NC score	0.379282 (rank : 201)	θ value	0.21417 (rank : 225)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

M3K5_HUMAN
NC score	0.379082 (rank : 202)	θ value	5.44631e-05 (rank : 13)
Query Neighborhood Hits	534	Target Neighborhood Hits	868	Shared Neighborhood Hits	342
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

ULK4_MOUSE
NC score	0.378882 (rank : 203)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	534	Target Neighborhood Hits	793	Shared Neighborhood Hits	329
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

M3K5_MOUSE
NC score	0.378877 (rank : 204)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	342
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

KPCE_HUMAN
NC score	0.378701 (rank : 205)	θ value	1.06291 (rank : 353)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	343
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

ST17A_HUMAN
NC score	0.378613 (rank : 206)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	339
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KS6A1_HUMAN
NC score	0.378521 (rank : 207)	θ value	0.279714 (rank : 246)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KGP2_HUMAN
NC score	0.378517 (rank : 208)	θ value	0.279714 (rank : 243)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	345
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC1_MOUSE
NC score	0.378288 (rank : 209)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	534	Target Neighborhood Hits	866	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

TSSK4_MOUSE
NC score	0.378156 (rank : 210)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	342
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KPCE_MOUSE
NC score	0.378004 (rank : 211)	θ value	1.81305 (rank : 393)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	343
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MK09_HUMAN
NC score	0.377929 (rank : 212)	θ value	0.365318 (rank : 270)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	346
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

KKCC2_HUMAN
NC score	0.377219 (rank : 213)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	340
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC1_HUMAN
NC score	0.377153 (rank : 214)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_MOUSE
NC score	0.377075 (rank : 215)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	534	Target Neighborhood Hits	855	Shared Neighborhood Hits	340
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

STK6_MOUSE
NC score	0.376551 (rank : 216)	θ value	6.88961 (rank : 507)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	344
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

MK15_HUMAN
NC score	0.375806 (rank : 217)	θ value	0.21417 (rank : 230)
Query Neighborhood Hits	534	Target Neighborhood Hits	1038	Shared Neighborhood Hits	348
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK09_MOUSE
NC score	0.375500 (rank : 218)	θ value	0.21417 (rank : 229)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

ST17B_HUMAN
NC score	0.375430 (rank : 219)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	339
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PAK6_HUMAN
NC score	0.375347 (rank : 220)	θ value	0.00102713 (rank : 46)
Query Neighborhood Hits	534	Target Neighborhood Hits	915	Shared Neighborhood Hits	345
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

STK6_HUMAN
NC score	0.375243 (rank : 221)	θ value	6.88961 (rank : 506)
Query Neighborhood Hits	534	Target Neighborhood Hits	916	Shared Neighborhood Hits	344
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

ST17B_MOUSE
NC score	0.374964 (rank : 222)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	340
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PLK1_MOUSE
NC score	0.374361 (rank : 223)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	340
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

STK36_HUMAN
NC score	0.374111 (rank : 224)	θ value	1.38821 (rank : 375)
Query Neighborhood Hits	534	Target Neighborhood Hits	896	Shared Neighborhood Hits	349
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TRIB3_HUMAN
NC score	0.373844 (rank : 225)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	534	Target Neighborhood Hits	519	Shared Neighborhood Hits	294
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

CD2L5_HUMAN
NC score	0.373558 (rank : 226)	θ value	0.00175202 (rank : 49)
Query Neighborhood Hits	534	Target Neighborhood Hits	987	Shared Neighborhood Hits	344
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

MK07_MOUSE
NC score	0.373509 (rank : 227)	θ value	0.0252991 (rank : 119)
Query Neighborhood Hits	534	Target Neighborhood Hits	1054	Shared Neighborhood Hits	344
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK04_HUMAN
NC score	0.373386 (rank : 228)	θ value	0.21417 (rank : 228)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	342
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

CD2L5_MOUSE
NC score	0.373312 (rank : 229)	θ value	0.00175202 (rank : 50)
Query Neighborhood Hits	534	Target Neighborhood Hits	1011	Shared Neighborhood Hits	345
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

GRK7_HUMAN
NC score	0.373108 (rank : 230)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	343
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

ICK_MOUSE
NC score	0.373061 (rank : 231)	θ value	0.0431538 (rank : 131)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	343
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MK07_HUMAN
NC score	0.373041 (rank : 232)	θ value	0.0252991 (rank : 118)
Query Neighborhood Hits	534	Target Neighborhood Hits	1087	Shared Neighborhood Hits	344
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

ARBK2_HUMAN
NC score	0.372892 (rank : 233)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ST32C_MOUSE
NC score	0.372796 (rank : 234)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	342
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST32C_HUMAN
NC score	0.372633 (rank : 235)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

PLK3_HUMAN
NC score	0.372554 (rank : 236)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	342
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

KGP2_MOUSE
NC score	0.372303 (rank : 237)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	534	Target Neighborhood Hits	1029	Shared Neighborhood Hits	344
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PLK3_MOUSE
NC score	0.372058 (rank : 238)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	534	Target Neighborhood Hits	863	Shared Neighborhood Hits	342
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

STK36_MOUSE
NC score	0.372028 (rank : 239)	θ value	1.38821 (rank : 376)
Query Neighborhood Hits	534	Target Neighborhood Hits	877	Shared Neighborhood Hits	344
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ICK_HUMAN
NC score	0.371836 (rank : 240)	θ value	0.0563607 (rank : 147)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ARBK1_MOUSE
NC score	0.371775 (rank : 241)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

MYLK2_HUMAN
NC score	0.371771 (rank : 242)	θ value	8.99809 (rank : 526)
Query Neighborhood Hits	534	Target Neighborhood Hits	920	Shared Neighborhood Hits	340
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MK04_MOUSE
NC score	0.371685 (rank : 243)	θ value	0.62314 (rank : 312)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	342
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

M3K8_MOUSE
NC score	0.371517 (rank : 244)	θ value	0.00175202 (rank : 57)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	338
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

SBK1_HUMAN
NC score	0.371254 (rank : 245)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	340
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MAK_MOUSE
NC score	0.371251 (rank : 246)	θ value	0.0431538 (rank : 134)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	343
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MK08_MOUSE
NC score	0.371116 (rank : 247)	θ value	2.36792 (rank : 413)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

SBK1_MOUSE
NC score	0.371061 (rank : 248)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	339
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MK08_HUMAN
NC score	0.370928 (rank : 249)	θ value	2.36792 (rank : 412)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

M3K15_HUMAN
NC score	0.370854 (rank : 250)	θ value	0.00509761 (rank : 79)
Query Neighborhood Hits	534	Target Neighborhood Hits	914	Shared Neighborhood Hits	342
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

ARBK1_HUMAN
NC score	0.370849 (rank : 251)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	342
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

TTK_HUMAN
NC score	0.370718 (rank : 252)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	534	Target Neighborhood Hits	816	Shared Neighborhood Hits	339
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

MAK_HUMAN
NC score	0.370601 (rank : 253)	θ value	0.0961366 (rank : 176)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	342
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PLK1_HUMAN
NC score	0.370348 (rank : 254)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	340
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MK10_HUMAN
NC score	0.370259 (rank : 255)	θ value	2.36792 (rank : 414)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	342
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
NC score	0.370222 (rank : 256)	θ value	2.36792 (rank : 415)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	342
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

CSKP_MOUSE
NC score	0.370139 (rank : 257)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	534	Target Neighborhood Hits	1027	Shared Neighborhood Hits	339
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

KGP1A_HUMAN
NC score	0.370061 (rank : 258)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	342
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

GSK3B_MOUSE
NC score	0.370059 (rank : 259)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	534	Target Neighborhood Hits	800	Shared Neighborhood Hits	340
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_HUMAN
NC score	0.370052 (rank : 260)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	534	Target Neighborhood Hits	801	Shared Neighborhood Hits	340
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

KGP1B_MOUSE
NC score	0.369805 (rank : 261)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	534	Target Neighborhood Hits	922	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

ST32B_HUMAN
NC score	0.369803 (rank : 262)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

KGP1B_HUMAN
NC score	0.369778 (rank : 263)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	534	Target Neighborhood Hits	921	Shared Neighborhood Hits	342
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

ST32B_MOUSE
NC score	0.369700 (rank : 264)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	342
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

NEK9_MOUSE
NC score	0.369389 (rank : 265)	θ value	0.000121331 (rank : 20)
Query Neighborhood Hits	534	Target Neighborhood Hits	890	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

PAK7_MOUSE
NC score	0.369322 (rank : 266)	θ value	0.0961366 (rank : 178)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	345
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PFTK1_MOUSE
NC score	0.369104 (rank : 267)	θ value	0.62314 (rank : 317)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	344
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

AL2S7_HUMAN
NC score	0.369099 (rank : 268)	θ value	0.0330416 (rank : 123)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	342
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CDK9_MOUSE
NC score	0.369085 (rank : 269)	θ value	0.0736092 (rank : 161)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	342
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CSKP_HUMAN
NC score	0.369039 (rank : 270)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	534	Target Neighborhood Hits	1022	Shared Neighborhood Hits	339
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PFTK1_HUMAN
NC score	0.369014 (rank : 271)	θ value	0.62314 (rank : 316)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	343
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

GSK3A_HUMAN
NC score	0.369007 (rank : 272)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	338
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

M3K6_HUMAN
NC score	0.368969 (rank : 273)	θ value	0.62314 (rank : 311)
Query Neighborhood Hits	534	Target Neighborhood Hits	889	Shared Neighborhood Hits	342
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

PAK7_HUMAN
NC score	0.368963 (rank : 274)	θ value	0.0961366 (rank : 177)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

MK01_MOUSE
NC score	0.368736 (rank : 275)	θ value	0.0431538 (rank : 137)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.368696 (rank : 276)	θ value	0.0431538 (rank : 136)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

NLK_MOUSE
NC score	0.368650 (rank : 277)	θ value	0.47712 (rank : 295)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	343
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.368645 (rank : 278)	θ value	0.47712 (rank : 294)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NEK9_HUMAN
NC score	0.368594 (rank : 279)	θ value	0.000121331 (rank : 19)
Query Neighborhood Hits	534	Target Neighborhood Hits	900	Shared Neighborhood Hits	343
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MK06_HUMAN
NC score	0.368573 (rank : 280)	θ value	0.365318 (rank : 268)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	338
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

CDK9_HUMAN
NC score	0.368320 (rank : 281)	θ value	0.163984 (rank : 198)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	342
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK3_HUMAN
NC score	0.368217 (rank : 282)	θ value	0.21417 (rank : 222)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	344
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

ST32A_HUMAN
NC score	0.368194 (rank : 283)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

PAK4_HUMAN
NC score	0.368054 (rank : 284)	θ value	0.813845 (rank : 338)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	344
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CD2L7_HUMAN
NC score	0.368015 (rank : 285)	θ value	0.0330416 (rank : 124)
Query Neighborhood Hits	534	Target Neighborhood Hits	1275	Shared Neighborhood Hits	351
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MK06_MOUSE
NC score	0.367978 (rank : 286)	θ value	0.365318 (rank : 269)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	338
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ULK3_MOUSE
NC score	0.367773 (rank : 287)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

M3K2_HUMAN
NC score	0.367752 (rank : 288)	θ value	0.163984 (rank : 212)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PLK2_HUMAN
NC score	0.367263 (rank : 289)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	342
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ST32A_MOUSE
NC score	0.367171 (rank : 290)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

PLK2_MOUSE
NC score	0.367111 (rank : 291)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	534	Target Neighborhood Hits	849	Shared Neighborhood Hits	341
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PAK4_MOUSE
NC score	0.366883 (rank : 292)	θ value	1.38821 (rank : 373)
Query Neighborhood Hits	534	Target Neighborhood Hits	1098	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK3_MOUSE
NC score	0.366869 (rank : 293)	θ value	0.813845 (rank : 337)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	344
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MK11_MOUSE
NC score	0.366826 (rank : 294)	θ value	0.813845 (rank : 336)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	343
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

ULK3_HUMAN
NC score	0.366688 (rank : 295)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PMYT1_MOUSE
NC score	0.366568 (rank : 296)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	343
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PDK1L_HUMAN
NC score	0.366413 (rank : 297)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	340
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

CDK3_MOUSE
NC score	0.366146 (rank : 298)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

KPCT_HUMAN
NC score	0.366065 (rank : 299)	θ value	6.88961 (rank : 500)
Query Neighborhood Hits	534	Target Neighborhood Hits	897	Shared Neighborhood Hits	343
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PDK1L_MOUSE
NC score	0.366036 (rank : 300)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	340
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

GRK5_HUMAN
NC score	0.365720 (rank : 301)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	338
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
NC score	0.365614 (rank : 302)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	338
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

CDC2_HUMAN
NC score	0.365595 (rank : 303)	θ value	5.27518 (rank : 467)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	344
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
NC score	0.365556 (rank : 304)	θ value	8.99809 (rank : 513)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	344
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

NEK2_MOUSE
NC score	0.365274 (rank : 305)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	534	Target Neighborhood Hits	876	Shared Neighborhood Hits	340
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

RK_MOUSE
NC score	0.365062 (rank : 306)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ULK2_MOUSE
NC score	0.365035 (rank : 307)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	534	Target Neighborhood Hits	943	Shared Neighborhood Hits	343
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

CDK5_HUMAN
NC score	0.365000 (rank : 308)	θ value	0.62314 (rank : 304)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	341
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.364986 (rank : 309)	θ value	0.62314 (rank : 305)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	341
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

PMYT1_HUMAN
NC score	0.364929 (rank : 310)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	534	Target Neighborhood Hits	814	Shared Neighborhood Hits	338
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

ULK2_HUMAN
NC score	0.364701 (rank : 311)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	534	Target Neighborhood Hits	979	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

GAK_MOUSE
NC score	0.364650 (rank : 312)	θ value	0.21417 (rank : 223)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	342
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

M3K8_HUMAN
NC score	0.364054 (rank : 313)	θ value	0.0252991 (rank : 116)
Query Neighborhood Hits	534	Target Neighborhood Hits	807	Shared Neighborhood Hits	338
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

RK_HUMAN
NC score	0.363860 (rank : 314)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	340
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

PKN3_HUMAN
NC score	0.363728 (rank : 315)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PCTK2_HUMAN
NC score	0.363726 (rank : 316)	θ value	0.47712 (rank : 296)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MK03_HUMAN
NC score	0.363696 (rank : 317)	θ value	0.0563607 (rank : 155)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

M3K3_HUMAN
NC score	0.363546 (rank : 318)	θ value	0.21417 (rank : 227)
Query Neighborhood Hits	534	Target Neighborhood Hits	885	Shared Neighborhood Hits	343
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK2_HUMAN
NC score	0.363530 (rank : 319)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	534	Target Neighborhood Hits	908	Shared Neighborhood Hits	342
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

MK03_MOUSE
NC score	0.363493 (rank : 320)	θ value	0.163984 (rank : 213)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	343
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

PCTK1_HUMAN
NC score	0.363455 (rank : 321)	θ value	4.03905 (rank : 454)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
NC score	0.363358 (rank : 322)	θ value	4.03905 (rank : 455)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CCRK_MOUSE
NC score	0.363266 (rank : 323)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	340
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

KPCG_HUMAN
NC score	0.363182 (rank : 324)	θ value	0.47712 (rank : 288)
Query Neighborhood Hits	534	Target Neighborhood Hits	1126	Shared Neighborhood Hits	341
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

TLK1_MOUSE
NC score	0.363155 (rank : 325)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	534	Target Neighborhood Hits	947	Shared Neighborhood Hits	342
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

NEK3_HUMAN
NC score	0.363096 (rank : 326)	θ value	0.62314 (rank : 313)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	344
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

PINK1_MOUSE
NC score	0.363093 (rank : 327)	θ value	0.00665767 (rank : 85)
Query Neighborhood Hits	534	Target Neighborhood Hits	726	Shared Neighborhood Hits	326
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PCTK2_MOUSE
NC score	0.363087 (rank : 328)	θ value	0.47712 (rank : 297)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	343
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

TLK1_HUMAN
NC score	0.363039 (rank : 329)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	534	Target Neighborhood Hits	967	Shared Neighborhood Hits	343
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

STK35_HUMAN
NC score	0.363018 (rank : 330)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	340
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

M3K3_MOUSE
NC score	0.362857 (rank : 331)	θ value	0.365318 (rank : 267)
Query Neighborhood Hits	534	Target Neighborhood Hits	876	Shared Neighborhood Hits	343
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK1_HUMAN
NC score	0.362836 (rank : 332)	θ value	8.99809 (rank : 527)
Query Neighborhood Hits	534	Target Neighborhood Hits	1129	Shared Neighborhood Hits	349
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

KPCG_MOUSE
NC score	0.362720 (rank : 333)	θ value	0.813845 (rank : 331)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	341
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PKN3_MOUSE
NC score	0.362672 (rank : 334)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	349
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CDK10_HUMAN
NC score	0.362640 (rank : 335)	θ value	2.36792 (rank : 404)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	344
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

M4K3_HUMAN
NC score	0.362608 (rank : 336)	θ value	0.00869519 (rank : 95)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	344
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

KPCD_MOUSE
NC score	0.362526 (rank : 337)	θ value	5.27518 (rank : 473)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	342
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

M3K2_MOUSE
NC score	0.362324 (rank : 338)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	343
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PKN2_MOUSE
NC score	0.362005 (rank : 339)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KPCT_MOUSE
NC score	0.361985 (rank : 340)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	534	Target Neighborhood Hits	895	Shared Neighborhood Hits	340
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCD_HUMAN
NC score	0.361850 (rank : 341)	θ value	8.99809 (rank : 523)
Query Neighborhood Hits	534	Target Neighborhood Hits	900	Shared Neighborhood Hits	342
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

CDK2_HUMAN
NC score	0.361847 (rank : 342)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

NEK4_MOUSE
NC score	0.361787 (rank : 343)	θ value	0.21417 (rank : 232)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	345
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

E2AK2_MOUSE
NC score	0.361708 (rank : 344)	θ value	0.0736092 (rank : 162)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	344
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ERN1_HUMAN
NC score	0.361690 (rank : 345)	θ value	0.0330416 (rank : 125)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	343
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CCRK_HUMAN
NC score	0.361612 (rank : 346)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	340
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

TLK2_HUMAN
NC score	0.361606 (rank : 347)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	534	Target Neighborhood Hits	1044	Shared Neighborhood Hits	345
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

STK16_HUMAN
NC score	0.361593 (rank : 348)	θ value	0.0961366 (rank : 180)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	344
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

GRK6_HUMAN
NC score	0.361563 (rank : 349)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	339
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

PKN2_HUMAN
NC score	0.361520 (rank : 350)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	345
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M4K5_MOUSE
NC score	0.361424 (rank : 351)	θ value	0.0148317 (rank : 105)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	344
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

DYRK2_HUMAN
NC score	0.361384 (rank : 352)	θ value	8.99809 (rank : 518)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	336
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

GRK6_MOUSE
NC score	0.361310 (rank : 353)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	339
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

CDK6_HUMAN
NC score	0.361277 (rank : 354)	θ value	0.125558 (rank : 183)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

PCTK3_MOUSE
NC score	0.361069 (rank : 355)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

ULK1_HUMAN
NC score	0.361024 (rank : 356)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	534	Target Neighborhood Hits	1121	Shared Neighborhood Hits	344
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

GAK_HUMAN
NC score	0.360972 (rank : 357)	θ value	0.0736092 (rank : 163)
Query Neighborhood Hits	534	Target Neighborhood Hits	1028	Shared Neighborhood Hits	342
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CDK6_MOUSE
NC score	0.360941 (rank : 358)	θ value	0.125558 (rank : 184)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	343
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

TLK2_MOUSE
NC score	0.360744 (rank : 359)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	534	Target Neighborhood Hits	1088	Shared Neighborhood Hits	345
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

CDK7_HUMAN
NC score	0.360645 (rank : 360)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
NC score	0.360602 (rank : 361)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	342
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

MK12_MOUSE
NC score	0.360555 (rank : 362)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	534	Target Neighborhood Hits	835	Shared Neighborhood Hits	342
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

M3K14_MOUSE
NC score	0.360389 (rank : 363)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	534	Target Neighborhood Hits	889	Shared Neighborhood Hits	341
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

NEK1_MOUSE
NC score	0.359972 (rank : 364)	θ value	8.99809 (rank : 528)
Query Neighborhood Hits	534	Target Neighborhood Hits	1311	Shared Neighborhood Hits	346
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

CDK4_HUMAN
NC score	0.359894 (rank : 365)	θ value	0.365318 (rank : 258)
Query Neighborhood Hits	534	Target Neighborhood Hits	834	Shared Neighborhood Hits	342
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MK13_MOUSE
NC score	0.359778 (rank : 366)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

NEK8_MOUSE
NC score	0.359744 (rank : 367)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

ULK1_MOUSE
NC score	0.359681 (rank : 368)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	534	Target Neighborhood Hits	1214	Shared Neighborhood Hits	346
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

BMP2K_MOUSE
NC score	0.359680 (rank : 369)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	340
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

NEK8_HUMAN
NC score	0.359632 (rank : 370)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	534	Target Neighborhood Hits	872	Shared Neighborhood Hits	342
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PAK2_MOUSE
NC score	0.359591 (rank : 371)	θ value	5.27518 (rank : 477)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	344
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

CDK4_MOUSE
NC score	0.359533 (rank : 372)	θ value	0.365318 (rank : 259)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

PAK2_HUMAN
NC score	0.359347 (rank : 373)	θ value	5.27518 (rank : 476)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	344
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

MK14_MOUSE
NC score	0.359312 (rank : 374)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CDK2_MOUSE
NC score	0.359306 (rank : 375)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	341
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

PKN1_MOUSE
NC score	0.359272 (rank : 376)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	534	Target Neighborhood Hits	888	Shared Neighborhood Hits	345
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PCTK3_HUMAN
NC score	0.359199 (rank : 377)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	534	Target Neighborhood Hits	827	Shared Neighborhood Hits	340
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

MK13_HUMAN
NC score	0.359121 (rank : 378)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK12_HUMAN
NC score	0.358945 (rank : 379)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	342
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PAK3_MOUSE
NC score	0.358897 (rank : 380)	θ value	4.03905 (rank : 451)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PKN1_HUMAN
NC score	0.358835 (rank : 381)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	343
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

TBK1_MOUSE
NC score	0.358770 (rank : 382)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	334
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

PAK3_HUMAN
NC score	0.358730 (rank : 383)	θ value	4.03905 (rank : 450)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	344
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

GRK4_MOUSE
NC score	0.358614 (rank : 384)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	337
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

M3K14_HUMAN
NC score	0.358610 (rank : 385)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	534	Target Neighborhood Hits	887	Shared Neighborhood Hits	341
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

TBK1_HUMAN
NC score	0.358519 (rank : 386)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	534	Target Neighborhood Hits	861	Shared Neighborhood Hits	336
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

MK14_HUMAN
NC score	0.358452 (rank : 387)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	342
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

M4K5_HUMAN
NC score	0.357988 (rank : 388)	θ value	0.0961366 (rank : 175)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

E2AK4_MOUSE
NC score	0.357842 (rank : 389)	θ value	0.62314 (rank : 307)
Query Neighborhood Hits	534	Target Neighborhood Hits	984	Shared Neighborhood Hits	342
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

HIPK4_HUMAN
NC score	0.357782 (rank : 390)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	338
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

GRK4_HUMAN
NC score	0.357647 (rank : 391)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	338
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MRCKG_HUMAN
NC score	0.357343 (rank : 392)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	534	Target Neighborhood Hits	1519	Shared Neighborhood Hits	347
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

CD2L6_HUMAN
NC score	0.357231 (rank : 393)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	340
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

ERN2_HUMAN
NC score	0.357146 (rank : 394)	θ value	1.06291 (rank : 348)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	344
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CD2L6_MOUSE
NC score	0.357119 (rank : 395)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	340
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

PINK1_HUMAN
NC score	0.356073 (rank : 396)	θ value	0.47712 (rank : 298)
Query Neighborhood Hits	534	Target Neighborhood Hits	741	Shared Neighborhood Hits	328
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MRCKG_MOUSE
NC score	0.356044 (rank : 397)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	534	Target Neighborhood Hits	1466	Shared Neighborhood Hits	349
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

BMP2K_HUMAN
NC score	0.355821 (rank : 398)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	339
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

M3K1_MOUSE
NC score	0.355721 (rank : 399)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	534	Target Neighborhood Hits	952	Shared Neighborhood Hits	343
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MK11_HUMAN
NC score	0.355511 (rank : 400)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	341
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

KPCA_HUMAN
NC score	0.355426 (rank : 401)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	534	Target Neighborhood Hits	1070	Shared Neighborhood Hits	341
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PAK1_MOUSE
NC score	0.355420 (rank : 402)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	534	Target Neighborhood Hits	878	Shared Neighborhood Hits	343
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK1_HUMAN
NC score	0.355383 (rank : 403)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	342
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

CDK8_HUMAN
NC score	0.355271 (rank : 404)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	341
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

NEK4_HUMAN
NC score	0.355159 (rank : 405)	θ value	6.88961 (rank : 502)
Query Neighborhood Hits	534	Target Neighborhood Hits	883	Shared Neighborhood Hits	344
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

IKKE_HUMAN
NC score	0.355067 (rank : 406)	θ value	8.99809 (rank : 520)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	338
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KPCA_MOUSE
NC score	0.354537 (rank : 407)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	534	Target Neighborhood Hits	1067	Shared Neighborhood Hits	340
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ERN1_MOUSE
NC score	0.354537 (rank : 408)	θ value	0.163984 (rank : 201)
Query Neighborhood Hits	534	Target Neighborhood Hits	823	Shared Neighborhood Hits	342
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CD2L1_MOUSE
NC score	0.354448 (rank : 409)	θ value	0.813845 (rank : 325)
Query Neighborhood Hits	534	Target Neighborhood Hits	1463	Shared Neighborhood Hits	349
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
NC score	0.354233 (rank : 410)	θ value	1.38821 (rank : 364)
Query Neighborhood Hits	534	Target Neighborhood Hits	1439	Shared Neighborhood Hits	348
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

IKKE_MOUSE
NC score	0.354192 (rank : 411)	θ value	6.88961 (rank : 499)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	338
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

DYRK3_HUMAN
NC score	0.354061 (rank : 412)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	534	Target Neighborhood Hits	798	Shared Neighborhood Hits	335
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

AAK1_HUMAN
NC score	0.353704 (rank : 413)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	534	Target Neighborhood Hits	1077	Shared Neighborhood Hits	343
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
NC score	0.353235 (rank : 414)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	534	Target Neighborhood Hits	1051	Shared Neighborhood Hits	340
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

NEK6_MOUSE
NC score	0.353044 (rank : 415)	θ value	0.21417 (rank : 233)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

KPCB_HUMAN
NC score	0.352458 (rank : 416)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	534	Target Neighborhood Hits	1121	Shared Neighborhood Hits	341
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

CD2L1_HUMAN
NC score	0.352389 (rank : 417)	θ value	1.38821 (rank : 363)
Query Neighborhood Hits	534	Target Neighborhood Hits	1467	Shared Neighborhood Hits	348
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

NEK7_MOUSE
NC score	0.352269 (rank : 418)	θ value	0.62314 (rank : 314)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	344
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

DYR1B_MOUSE
NC score	0.352149 (rank : 419)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	534	Target Neighborhood Hits	799	Shared Neighborhood Hits	334
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

KPCB_MOUSE
NC score	0.351936 (rank : 420)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	534	Target Neighborhood Hits	1117	Shared Neighborhood Hits	341
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

E2AK3_MOUSE
NC score	0.351880 (rank : 421)	θ value	0.47712 (rank : 285)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

SPEG_HUMAN
NC score	0.351690 (rank : 422)	θ value	0.0961366 (rank : 179)
Query Neighborhood Hits	534	Target Neighborhood Hits	1762	Shared Neighborhood Hits	349
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK16_MOUSE
NC score	0.351581 (rank : 423)	θ value	6.88961 (rank : 505)
Query Neighborhood Hits	534	Target Neighborhood Hits	824	Shared Neighborhood Hits	342
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

DYRK4_HUMAN
NC score	0.350992 (rank : 424)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	534	Target Neighborhood Hits	750	Shared Neighborhood Hits	324
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

M4K2_HUMAN
NC score	0.350955 (rank : 425)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	342
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
NC score	0.350879 (rank : 426)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	342
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

NEK6_HUMAN
NC score	0.350481 (rank : 427)	θ value	5.27518 (rank : 475)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	344
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

DYR1A_HUMAN
NC score	0.350067 (rank : 428)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	534	Target Neighborhood Hits	764	Shared Neighborhood Hits	331
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

NEK7_HUMAN
NC score	0.350052 (rank : 429)	θ value	3.0926 (rank : 431)
Query Neighborhood Hits	534	Target Neighborhood Hits	846	Shared Neighborhood Hits	344
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

UHMK1_HUMAN
NC score	0.350044 (rank : 430)	θ value	0.163984 (rank : 219)
Query Neighborhood Hits	534	Target Neighborhood Hits	808	Shared Neighborhood Hits	328
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

DYR1B_HUMAN
NC score	0.350037 (rank : 431)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	333
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1A_MOUSE
NC score	0.350020 (rank : 432)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	534	Target Neighborhood Hits	762	Shared Neighborhood Hits	331
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

SPEG_MOUSE
NC score	0.349937 (rank : 433)	θ value	0.163984 (rank : 218)
Query Neighborhood Hits	534	Target Neighborhood Hits	1959	Shared Neighborhood Hits	351
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CLK1_HUMAN
NC score	0.349801 (rank : 434)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	534	Target Neighborhood Hits	756	Shared Neighborhood Hits	327
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

E2AK3_HUMAN
NC score	0.349494 (rank : 435)	θ value	2.36792 (rank : 407)
Query Neighborhood Hits	534	Target Neighborhood Hits	859	Shared Neighborhood Hits	344
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

UHMK1_MOUSE
NC score	0.349023 (rank : 436)	θ value	0.21417 (rank : 238)
Query Neighborhood Hits	534	Target Neighborhood Hits	809	Shared Neighborhood Hits	328
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

HIPK1_HUMAN
NC score	0.348935 (rank : 437)	θ value	1.06291 (rank : 351)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	333
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.348886 (rank : 438)	θ value	1.06291 (rank : 352)
Query Neighborhood Hits	534	Target Neighborhood Hits	838	Shared Neighborhood Hits	333
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

CLK1_MOUSE
NC score	0.348223 (rank : 439)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	327
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

E2AK4_HUMAN
NC score	0.348073 (rank : 440)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	534	Target Neighborhood Hits	1012	Shared Neighborhood Hits	344
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MYLK_MOUSE
NC score	0.347167 (rank : 441)	θ value	0.0330416 (rank : 127)
Query Neighborhood Hits	534	Target Neighborhood Hits	1489	Shared Neighborhood Hits	345
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

OXSR1_HUMAN
NC score	0.347120 (rank : 442)	θ value	1.38821 (rank : 371)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	345
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
NC score	0.346842 (rank : 443)	θ value	1.38821 (rank : 372)
Query Neighborhood Hits	534	Target Neighborhood Hits	865	Shared Neighborhood Hits	344
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

MYLK_HUMAN
NC score	0.346819 (rank : 444)	θ value	0.0736092 (rank : 169)
Query Neighborhood Hits	534	Target Neighborhood Hits	1328	Shared Neighborhood Hits	343
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

STK39_MOUSE
NC score	0.346689 (rank : 445)	θ value	1.38821 (rank : 378)
Query Neighborhood Hits	534	Target Neighborhood Hits	915	Shared Neighborhood Hits	344
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TRIO_HUMAN
NC score	0.346678 (rank : 446)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	534	Target Neighborhood Hits	1580	Shared Neighborhood Hits	347
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

STK39_HUMAN
NC score	0.346554 (rank : 447)	θ value	1.38821 (rank : 377)
Query Neighborhood Hits	534	Target Neighborhood Hits	882	Shared Neighborhood Hits	344
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

DUET_HUMAN
NC score	0.346519 (rank : 448)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	534	Target Neighborhood Hits	1220	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

IKKB_MOUSE
NC score	0.346324 (rank : 449)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	534	Target Neighborhood Hits	984	Shared Neighborhood Hits	340
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CLK2_HUMAN
NC score	0.346220 (rank : 450)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	534	Target Neighborhood Hits	752	Shared Neighborhood Hits	325
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

IKKB_HUMAN
NC score	0.345948 (rank : 451)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	340
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CLK4_HUMAN
NC score	0.344591 (rank : 452)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CDC7_MOUSE
NC score	0.344571 (rank : 453)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	534	Target Neighborhood Hits	641	Shared Neighborhood Hits	324
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

ERN2_MOUSE
NC score	0.344341 (rank : 454)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	339
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

E2AK2_HUMAN
NC score	0.343876 (rank : 455)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	534	Target Neighborhood Hits	856	Shared Neighborhood Hits	342
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

CLK4_MOUSE
NC score	0.343802 (rank : 456)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

NEK11_MOUSE
NC score	0.343582 (rank : 457)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	534	Target Neighborhood Hits	875	Shared Neighborhood Hits	342
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

IKKA_MOUSE
NC score	0.342747 (rank : 458)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	343
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NRK_MOUSE
NC score	0.342573 (rank : 459)	θ value	0.62314 (rank : 315)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	343
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

CLK2_MOUSE
NC score	0.342542 (rank : 460)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	534	Target Neighborhood Hits	743	Shared Neighborhood Hits	325
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

IKKA_HUMAN
NC score	0.342292 (rank : 461)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	534	Target Neighborhood Hits	863	Shared Neighborhood Hits	342
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

M4K1_HUMAN
NC score	0.341843 (rank : 462)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	342
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
NC score	0.341749 (rank : 463)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

HIPK3_HUMAN
NC score	0.341741 (rank : 464)	θ value	8.99809 (rank : 519)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	335
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

NRK_HUMAN
NC score	0.341526 (rank : 465)	θ value	2.36792 (rank : 416)
Query Neighborhood Hits	534	Target Neighborhood Hits	931	Shared Neighborhood Hits	342
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

ROCK2_HUMAN
NC score	0.341307 (rank : 466)	θ value	0.279714 (rank : 253)
Query Neighborhood Hits	534	Target Neighborhood Hits	2073	Shared Neighborhood Hits	353
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

HIPK2_HUMAN
NC score	0.341307 (rank : 467)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	534	Target Neighborhood Hits	845	Shared Neighborhood Hits	331
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.341128 (rank : 468)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	534	Target Neighborhood Hits	871	Shared Neighborhood Hits	331
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

NEK11_HUMAN
NC score	0.341122 (rank : 469)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	534	Target Neighborhood Hits	1043	Shared Neighborhood Hits	345
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TNIK_HUMAN
NC score	0.340670 (rank : 470)	θ value	0.0961366 (rank : 182)
Query Neighborhood Hits	534	Target Neighborhood Hits	1570	Shared Neighborhood Hits	352
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

DAPK1_HUMAN
NC score	0.340217 (rank : 471)	θ value	8.99809 (rank : 514)
Query Neighborhood Hits	534	Target Neighborhood Hits	1130	Shared Neighborhood Hits	343
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

HIPK3_MOUSE
NC score	0.340137 (rank : 472)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	332
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

MP2K7_HUMAN
NC score	0.340057 (rank : 473)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	342
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

CDC7_HUMAN
NC score	0.339744 (rank : 474)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	534	Target Neighborhood Hits	652	Shared Neighborhood Hits	321
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

DAPK1_MOUSE
NC score	0.339347 (rank : 475)	θ value	6.88961 (rank : 497)
Query Neighborhood Hits	534	Target Neighborhood Hits	1138	Shared Neighborhood Hits	343
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ROCK2_MOUSE
NC score	0.339023 (rank : 476)	θ value	0.21417 (rank : 236)
Query Neighborhood Hits	534	Target Neighborhood Hits	2072	Shared Neighborhood Hits	351
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

WNK3_HUMAN
NC score	0.338783 (rank : 477)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	534	Target Neighborhood Hits	948	Shared Neighborhood Hits	341
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

YSK4_HUMAN
NC score	0.337811 (rank : 478)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	534	Target Neighborhood Hits	921	Shared Neighborhood Hits	343
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

E2AK1_MOUSE
NC score	0.337107 (rank : 479)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	341
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CTRO_HUMAN
NC score	0.336297 (rank : 480)	θ value	0.813845 (rank : 329)
Query Neighborhood Hits	534	Target Neighborhood Hits	2092	Shared Neighborhood Hits	352
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CI096_HUMAN
NC score	0.336268 (rank : 481)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	332
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

RPKL1_MOUSE
NC score	0.336168 (rank : 482)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	534	Target Neighborhood Hits	704	Shared Neighborhood Hits	312
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

OBSCN_HUMAN
NC score	0.335909 (rank : 483)	θ value	1.06291 (rank : 354)
Query Neighborhood Hits	534	Target Neighborhood Hits	1931	Shared Neighborhood Hits	348
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ROCK1_HUMAN
NC score	0.335854 (rank : 484)	θ value	1.81305 (rank : 395)
Query Neighborhood Hits	534	Target Neighborhood Hits	2000	Shared Neighborhood Hits	347
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

PRP4B_HUMAN
NC score	0.335826 (rank : 485)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	534	Target Neighborhood Hits	1030	Shared Neighborhood Hits	333
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

RPKL1_HUMAN
NC score	0.335748 (rank : 486)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	534	Target Neighborhood Hits	708	Shared Neighborhood Hits	315
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

CLK3_HUMAN
NC score	0.335724 (rank : 487)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	328
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

MRCKA_HUMAN
NC score	0.335467 (rank : 488)	θ value	5.27518 (rank : 474)
Query Neighborhood Hits	534	Target Neighborhood Hits	1999	Shared Neighborhood Hits	356
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CLK3_MOUSE
NC score	0.335454 (rank : 489)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	534	Target Neighborhood Hits	761	Shared Neighborhood Hits	328
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

M4K4_HUMAN
NC score	0.335129 (rank : 490)	θ value	0.813845 (rank : 334)
Query Neighborhood Hits	534	Target Neighborhood Hits	1589	Shared Neighborhood Hits	350
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PRP4B_MOUSE
NC score	0.334921 (rank : 491)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	534	Target Neighborhood Hits	1040	Shared Neighborhood Hits	332
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

E2AK1_HUMAN
NC score	0.334292 (rank : 492)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

STK3_HUMAN
NC score	0.334023 (rank : 493)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	534	Target Neighborhood Hits	861	Shared Neighborhood Hits	340
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

MP2K1_HUMAN
NC score	0.333901 (rank : 494)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

STK3_MOUSE
NC score	0.333838 (rank : 495)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	534	Target Neighborhood Hits	869	Shared Neighborhood Hits	340
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

MP2K1_MOUSE
NC score	0.333709 (rank : 496)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
NC score	0.333391 (rank : 497)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	338
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
NC score	0.333355 (rank : 498)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	338
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

WNK4_MOUSE
NC score	0.333350 (rank : 499)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	534	Target Neighborhood Hits	961	Shared Neighborhood Hits	339
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

STK4_MOUSE
NC score	0.333222 (rank : 500)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	341
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.333088 (rank : 501)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	534	Target Neighborhood Hits	870	Shared Neighborhood Hits	341
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK24_MOUSE
NC score	0.332917 (rank : 502)	θ value	5.27518 (rank : 481)
Query Neighborhood Hits	534	Target Neighborhood Hits	856	Shared Neighborhood Hits	344
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

MINK1_MOUSE
NC score	0.332903 (rank : 503)	θ value	8.99809 (rank : 525)
Query Neighborhood Hits	534	Target Neighborhood Hits	1451	Shared Neighborhood Hits	346
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.332796 (rank : 504)	θ value	8.99809 (rank : 524)
Query Neighborhood Hits	534	Target Neighborhood Hits	1477	Shared Neighborhood Hits	346
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

SLK_MOUSE
NC score	0.331910 (rank : 505)	θ value	5.27518 (rank : 480)
Query Neighborhood Hits	534	Target Neighborhood Hits	1798	Shared Neighborhood Hits	351
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SLK_HUMAN
NC score	0.331719 (rank : 506)	θ value	4.03905 (rank : 458)
Query Neighborhood Hits	534	Target Neighborhood Hits	1775	Shared Neighborhood Hits	350
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK24_HUMAN
NC score	0.331441 (rank : 507)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK25_HUMAN
NC score	0.331312 (rank : 508)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	534	Target Neighborhood Hits	853	Shared Neighborhood Hits	342
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MST4_MOUSE
NC score	0.331237 (rank : 509)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	534	Target Neighborhood Hits	860	Shared Neighborhood Hits	342
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

WNK4_HUMAN
NC score	0.331211 (rank : 510)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	534	Target Neighborhood Hits	1043	Shared Neighborhood Hits	333
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MST4_HUMAN
NC score	0.331155 (rank : 511)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	534	Target Neighborhood Hits	852	Shared Neighborhood Hits	342
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK25_MOUSE
NC score	0.330655 (rank : 512)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	342
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MP2K6_MOUSE
NC score	0.330053 (rank : 513)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	338
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K4_HUMAN
NC score	0.329710 (rank : 514)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	534	Target Neighborhood Hits	832	Shared Neighborhood Hits	341
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

WEE1_MOUSE
NC score	0.329627 (rank : 515)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	534	Target Neighborhood Hits	794	Shared Neighborhood Hits	329
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

MP2K4_MOUSE
NC score	0.329625 (rank : 516)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	341
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K6_HUMAN
NC score	0.329434 (rank : 517)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	534	Target Neighborhood Hits	830	Shared Neighborhood Hits	337
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

ROCK1_MOUSE
NC score	0.329189 (rank : 518)	θ value	1.81305 (rank : 396)
Query Neighborhood Hits	534	Target Neighborhood Hits	2126	Shared Neighborhood Hits	350
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RIPK5_MOUSE
NC score	0.329023 (rank : 519)	θ value	0.47712 (rank : 299)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	344
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK5_HUMAN
NC score	0.328979 (rank : 520)	θ value	0.62314 (rank : 320)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	344
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

MP2K3_MOUSE
NC score	0.328935 (rank : 521)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	534	Target Neighborhood Hits	826	Shared Neighborhood Hits	337
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

M4K4_MOUSE
NC score	0.328464 (rank : 522)	θ value	0.813845 (rank : 335)
Query Neighborhood Hits	534	Target Neighborhood Hits	1560	Shared Neighborhood Hits	349
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MP2K5_MOUSE
NC score	0.328358 (rank : 523)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	534	Target Neighborhood Hits	840	Shared Neighborhood Hits	340
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

KS6C1_HUMAN
NC score	0.328105 (rank : 524)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	534	Target Neighborhood Hits	682	Shared Neighborhood Hits	322
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

WNK1_HUMAN
NC score	0.327879 (rank : 525)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	534	Target Neighborhood Hits	1158	Shared Neighborhood Hits	339
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
NC score	0.327860 (rank : 526)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	534	Target Neighborhood Hits	1179	Shared Neighborhood Hits	342
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

MP2K3_HUMAN
NC score	0.327834 (rank : 527)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	534	Target Neighborhood Hits	825	Shared Neighborhood Hits	337
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

KS6C1_MOUSE
NC score	0.327411 (rank : 528)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	534	Target Neighborhood Hits	700	Shared Neighborhood Hits	318
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

WNK2_HUMAN
NC score	0.327246 (rank : 529)	θ value	5.27518 (rank : 492)
Query Neighborhood Hits	534	Target Neighborhood Hits	1407	Shared Neighborhood Hits	341
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

TAOK3_MOUSE
NC score	0.327163 (rank : 530)	θ value	0.0961366 (rank : 181)
Query Neighborhood Hits	534	Target Neighborhood Hits	1458	Shared Neighborhood Hits	352
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK2_HUMAN
NC score	0.327040 (rank : 531)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	534	Target Neighborhood Hits	1172	Shared Neighborhood Hits	348
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CTRO_MOUSE
NC score	0.326733 (rank : 532)	θ value	0.62314 (rank : 306)
Query Neighborhood Hits	534	Target Neighborhood Hits	2344	Shared Neighborhood Hits	354
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MP2K5_HUMAN
NC score	0.326108 (rank : 533)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	534	Target Neighborhood Hits	837	Shared Neighborhood Hits	340
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MRCKB_MOUSE
NC score	0.326008 (rank : 534)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	534	Target Neighborhood Hits	2180	Shared Neighborhood Hits	346
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

WEE1B_MOUSE
NC score	0.324685 (rank : 535)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	534	Target Neighborhood Hits	765	Shared Neighborhood Hits	328
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

WEE1_HUMAN
NC score	0.324632 (rank : 536)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	534	Target Neighborhood Hits	777	Shared Neighborhood Hits	325
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

AL2S2_HUMAN
NC score	0.323475 (rank : 537)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	534	Target Neighborhood Hits	727	Shared Neighborhood Hits	324
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

TAOK3_HUMAN
NC score	0.322713 (rank : 538)	θ value	4.03905 (rank : 459)
Query Neighborhood Hits	534	Target Neighborhood Hits	1494	Shared Neighborhood Hits	352
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

MRCKB_HUMAN
NC score	0.322093 (rank : 539)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	534	Target Neighborhood Hits	2239	Shared Neighborhood Hits	351
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TAOK2_MOUSE
NC score	0.321833 (rank : 540)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	534	Target Neighborhood Hits	1373	Shared Neighborhood Hits	349
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

WEE1B_HUMAN
NC score	0.321759 (rank : 541)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	328
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

STK10_HUMAN
NC score	0.321192 (rank : 542)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	534	Target Neighborhood Hits	1921	Shared Neighborhood Hits	355
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

AL2S2_MOUSE
NC score	0.317119 (rank : 543)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	534	Target Neighborhood Hits	709	Shared Neighborhood Hits	317
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

TAOK1_MOUSE
NC score	0.315208 (rank : 544)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	534	Target Neighborhood Hits	1720	Shared Neighborhood Hits	352
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.314985 (rank : 545)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	534	Target Neighborhood Hits	1734	Shared Neighborhood Hits	352
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

STK10_MOUSE
NC score	0.312441 (rank : 546)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	534	Target Neighborhood Hits	2132	Shared Neighborhood Hits	357
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

IRAK4_MOUSE
NC score	0.309603 (rank : 547)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	338
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KSR2_HUMAN
NC score	0.308143 (rank : 548)	θ value	0.279714 (rank : 247)
Query Neighborhood Hits	534	Target Neighborhood Hits	920	Shared Neighborhood Hits	342
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RIPK3_MOUSE
NC score	0.305377 (rank : 549)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	338
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

IRAK4_HUMAN
NC score	0.305227 (rank : 550)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	534	Target Neighborhood Hits	816	Shared Neighborhood Hits	340
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

TESK1_MOUSE
NC score	0.304864 (rank : 551)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	534	Target Neighborhood Hits	862	Shared Neighborhood Hits	336
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_HUMAN
NC score	0.304144 (rank : 552)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	534	Target Neighborhood Hits	864	Shared Neighborhood Hits	337
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

RIPK1_HUMAN
NC score	0.303787 (rank : 553)	θ value	0.62314 (rank : 319)
Query Neighborhood Hits	534	Target Neighborhood Hits	891	Shared Neighborhood Hits	344
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

KC1A_HUMAN
NC score	0.301726 (rank : 554)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	329
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.301726 (rank : 555)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	329
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

M3K13_HUMAN
NC score	0.300822 (rank : 556)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	343
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MYO3A_MOUSE
NC score	0.299159 (rank : 557)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	534	Target Neighborhood Hits	902	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

KC1AL_HUMAN
NC score	0.297806 (rank : 558)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	534	Target Neighborhood Hits	734	Shared Neighborhood Hits	330
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

TESK2_HUMAN
NC score	0.296597 (rank : 559)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	339
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
NC score	0.296279 (rank : 560)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	340
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

RIPK3_HUMAN
NC score	0.295830 (rank : 561)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	534	Target Neighborhood Hits	828	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

TITIN_HUMAN
NC score	0.295788 (rank : 562)	θ value	1.38821 (rank : 386)
Query Neighborhood Hits	534	Target Neighborhood Hits	2923	Shared Neighborhood Hits	350
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

KSR1_MOUSE
NC score	0.294985 (rank : 563)	θ value	0.365318 (rank : 266)
Query Neighborhood Hits	534	Target Neighborhood Hits	870	Shared Neighborhood Hits	342
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MYO3A_HUMAN
NC score	0.294529 (rank : 564)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	534	Target Neighborhood Hits	1033	Shared Neighborhood Hits	343
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
NC score	0.294499 (rank : 565)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	534	Target Neighborhood Hits	923	Shared Neighborhood Hits	341
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

M3K12_HUMAN
NC score	0.294255 (rank : 566)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	534	Target Neighborhood Hits	940	Shared Neighborhood Hits	344
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.294161 (rank : 567)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	534	Target Neighborhood Hits	957	Shared Neighborhood Hits	343
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

TTBK1_HUMAN
NC score	0.292592 (rank : 568)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	331
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

LIMK2_HUMAN
NC score	0.292436 (rank : 569)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	534	Target Neighborhood Hits	986	Shared Neighborhood Hits	340
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ARAF_HUMAN
NC score	0.292174 (rank : 570)	θ value	4.03905 (rank : 440)
Query Neighborhood Hits	534	Target Neighborhood Hits	924	Shared Neighborhood Hits	346
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
NC score	0.291813 (rank : 571)	θ value	5.27518 (rank : 466)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	347
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

RIPK1_MOUSE
NC score	0.291772 (rank : 572)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	342
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

LIMK2_MOUSE
NC score	0.291181 (rank : 573)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	534	Target Neighborhood Hits	998	Shared Neighborhood Hits	341
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TTBK2_HUMAN
NC score	0.290922 (rank : 574)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	534	Target Neighborhood Hits	822	Shared Neighborhood Hits	325
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

RAF1_MOUSE
NC score	0.290622 (rank : 575)	θ value	4.03905 (rank : 456)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	347
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

AVR2B_MOUSE
NC score	0.290080 (rank : 576)	θ value	0.163984 (rank : 196)
Query Neighborhood Hits	534	Target Neighborhood Hits	749	Shared Neighborhood Hits	332
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.289917 (rank : 577)	θ value	0.163984 (rank : 195)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	332
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

KSR1_HUMAN
NC score	0.289168 (rank : 578)	θ value	0.365318 (rank : 265)
Query Neighborhood Hits	534	Target Neighborhood Hits	867	Shared Neighborhood Hits	339
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

M3K7_MOUSE
NC score	0.289070 (rank : 579)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	346
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TTBK2_MOUSE
NC score	0.289067 (rank : 580)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	325
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

M3K7_HUMAN
NC score	0.288857 (rank : 581)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	534	Target Neighborhood Hits	892	Shared Neighborhood Hits	346
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

LIMK1_HUMAN
NC score	0.288116 (rank : 582)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	534	Target Neighborhood Hits	1005	Shared Neighborhood Hits	342
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.287614 (rank : 583)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	534	Target Neighborhood Hits	1008	Shared Neighborhood Hits	343
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RAF1_HUMAN
NC score	0.287600 (rank : 584)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	534	Target Neighborhood Hits	886	Shared Neighborhood Hits	345
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

KC1E_HUMAN
NC score	0.286287 (rank : 585)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	534	Target Neighborhood Hits	732	Shared Neighborhood Hits	328
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.286270 (rank : 586)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	534	Target Neighborhood Hits	728	Shared Neighborhood Hits	328
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_MOUSE
NC score	0.286041 (rank : 587)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	534	Target Neighborhood Hits	713	Shared Neighborhood Hits	328
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

BRAF1_HUMAN
NC score	0.285952 (rank : 588)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	534	Target Neighborhood Hits	883	Shared Neighborhood Hits	344
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

MOS_MOUSE
NC score	0.285328 (rank : 589)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	534	Target Neighborhood Hits	833	Shared Neighborhood Hits	344
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KC1G1_HUMAN
NC score	0.284796 (rank : 590)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	534	Target Neighborhood Hits	708	Shared Neighborhood Hits	328
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1D_HUMAN
NC score	0.284581 (rank : 591)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	534	Target Neighborhood Hits	737	Shared Neighborhood Hits	329
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.284576 (rank : 592)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	534	Target Neighborhood Hits	737	Shared Neighborhood Hits	329
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1G3_HUMAN
NC score	0.283985 (rank : 593)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	534	Target Neighborhood Hits	711	Shared Neighborhood Hits	328
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

MOS_HUMAN
NC score	0.283502 (rank : 594)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	534	Target Neighborhood Hits	829	Shared Neighborhood Hits	342
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MLTK_MOUSE
NC score	0.282996 (rank : 595)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	534	Target Neighborhood Hits	874	Shared Neighborhood Hits	341
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.282275 (rank : 596)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	534	Target Neighborhood Hits	911	Shared Neighborhood Hits	341
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

M3K9_HUMAN
NC score	0.281730 (rank : 597)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	534	Target Neighborhood Hits	1123	Shared Neighborhood Hits	346
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.281265 (rank : 598)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	534	Target Neighborhood Hits	1071	Shared Neighborhood Hits	344
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
NC score	0.280593 (rank : 599)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	534	Target Neighborhood Hits	1136	Shared Neighborhood Hits	349
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TGFR2_MOUSE
NC score	0.274802 (rank : 600)	θ value	1.38821 (rank : 383)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	319
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.273385 (rank : 601)	θ value	1.81305 (rank : 398)
Query Neighborhood Hits	534	Target Neighborhood Hits	748	Shared Neighborhood Hits	318
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

M3KL4_HUMAN
NC score	0.272833 (rank : 602)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	534	Target Neighborhood Hits	1087	Shared Neighborhood Hits	345
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RIPK2_HUMAN
NC score	0.272396 (rank : 603)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	534	Target Neighborhood Hits	774	Shared Neighborhood Hits	327
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
NC score	0.272236 (rank : 604)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	534	Target Neighborhood Hits	776	Shared Neighborhood Hits	325
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

KC1G2_MOUSE
NC score	0.271441 (rank : 605)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	534	Target Neighborhood Hits	695	Shared Neighborhood Hits	325
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

AVR2A_MOUSE
NC score	0.270290 (rank : 606)	θ value	4.03905 (rank : 442)
Query Neighborhood Hits	534	Target Neighborhood Hits	767	Shared Neighborhood Hits	332
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.270287 (rank : 607)	θ value	4.03905 (rank : 441)
Query Neighborhood Hits	534	Target Neighborhood Hits	767	Shared Neighborhood Hits	332
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

LRRK1_HUMAN
NC score	0.270122 (rank : 608)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	534	Target Neighborhood Hits	1237	Shared Neighborhood Hits	342
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

KC1G2_HUMAN
NC score	0.269481 (rank : 609)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	534	Target Neighborhood Hits	693	Shared Neighborhood Hits	324
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

JAK3_MOUSE
NC score	0.267695 (rank : 610)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	534	Target Neighborhood Hits	821	Shared Neighborhood Hits	341
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

IRAK2_HUMAN
NC score	0.267250 (rank : 611)	θ value	3.0926 (rank : 430)
Query Neighborhood Hits	534	Target Neighborhood Hits	714	Shared Neighborhood Hits	306
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

LRRK2_HUMAN
NC score	0.267126 (rank : 612)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	534	Target Neighborhood Hits	1382	Shared Neighborhood Hits	349
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

SCYL2_HUMAN
NC score	0.266574 (rank : 613)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	534	Target Neighborhood Hits	632	Shared Neighborhood Hits	251
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

LRRK1_MOUSE
NC score	0.265214 (rank : 614)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	534	Target Neighborhood Hits	1267	Shared Neighborhood Hits	342
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

IRAK1_HUMAN
NC score	0.265135 (rank : 615)	θ value	5.27518 (rank : 472)
Query Neighborhood Hits	534	Target Neighborhood Hits	820	Shared Neighborhood Hits	319
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

JAK2_MOUSE
NC score	0.262725 (rank : 616)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	534	Target Neighborhood Hits	839	Shared Neighborhood Hits	343
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

TYK2_HUMAN
NC score	0.262614 (rank : 617)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	534	Target Neighborhood Hits	841	Shared Neighborhood Hits	343
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK2_HUMAN
NC score	0.262399 (rank : 618)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	345
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LRRK2_MOUSE
NC score	0.261458 (rank : 619)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	534	Target Neighborhood Hits	1359	Shared Neighborhood Hits	342
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

JAK3_HUMAN
NC score	0.258925 (rank : 620)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	534	Target Neighborhood Hits	827	Shared Neighborhood Hits	342
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

SCYL2_MOUSE
NC score	0.258620 (rank : 621)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	534	Target Neighborhood Hits	603	Shared Neighborhood Hits	241
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

WD51A_HUMAN
NC score	0.258529 (rank : 622)	θ value	1.69304e-06 (rank : 4)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NBT0, Q2TAK6, Q96IK6, Q9UFJ8	Gene names	WDR51A
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

TYK2_MOUSE
NC score	0.257855 (rank : 623)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	343
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BUB1_MOUSE
NC score	0.257007 (rank : 624)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	534	Target Neighborhood Hits	583	Shared Neighborhood Hits	287
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

IRAK1_MOUSE
NC score	0.256796 (rank : 625)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	534	Target Neighborhood Hits	784	Shared Neighborhood Hits	319
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

WD51A_MOUSE
NC score	0.254878 (rank : 626)	θ value	1.09739e-05 (rank : 10)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZX3, Q9CY09	Gene names	Wdr51a
Domain Architecture	No domain graphic available
Description	WD repeat protein 51A.

JAK1_HUMAN
NC score	0.254373 (rank : 627)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	342
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ACVR1_MOUSE
NC score	0.253742 (rank : 628)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	534	Target Neighborhood Hits	768	Shared Neighborhood Hits	326
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

BMR1B_MOUSE
NC score	0.252883 (rank : 629)	θ value	4.03905 (rank : 444)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	325
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.252569 (rank : 630)	θ value	4.03905 (rank : 443)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	326
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1A_HUMAN
NC score	0.252517 (rank : 631)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	534	Target Neighborhood Hits	759	Shared Neighborhood Hits	326
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
NC score	0.252197 (rank : 632)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	534	Target Neighborhood Hits	758	Shared Neighborhood Hits	325
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

ACVR1_HUMAN
NC score	0.251357 (rank : 633)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	534	Target Neighborhood Hits	760	Shared Neighborhood Hits	325
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

TGFR1_HUMAN
NC score	0.250342 (rank : 634)	θ value	1.38821 (rank : 381)
Query Neighborhood Hits	534	Target Neighborhood Hits	755	Shared Neighborhood Hits	326
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

WD51B_MOUSE
NC score	0.250109 (rank : 635)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	534	Target Neighborhood Hits	321	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BHD1	Gene names	Wdr51b
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

TGFR1_MOUSE
NC score	0.250069 (rank : 636)	θ value	1.38821 (rank : 382)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	326
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

JAK1_MOUSE
NC score	0.249287 (rank : 637)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	534	Target Neighborhood Hits	854	Shared Neighborhood Hits	339
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

FES_MOUSE
NC score	0.249151 (rank : 638)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	344
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ACV1B_HUMAN
NC score	0.248892 (rank : 639)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	328
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
NC score	0.248772 (rank : 640)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	534	Target Neighborhood Hits	753	Shared Neighborhood Hits	328
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

PLRG1_MOUSE
NC score	0.248582 (rank : 641)	θ value	0.000786445 (rank : 42)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	143
SwissProt Accessions	Q922V4, O55039	Gene names	Plrg1
Domain Architecture
Description	Pleiotropic regulator 1.

PTK6_HUMAN
NC score	0.247925 (rank : 642)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	534	Target Neighborhood Hits	1020	Shared Neighborhood Hits	340
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

FES_HUMAN
NC score	0.247507 (rank : 643)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	534	Target Neighborhood Hits	978	Shared Neighborhood Hits	344
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

APAF_HUMAN
NC score	0.246877 (rank : 644)	θ value	0.00102713 (rank : 43)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	147
SwissProt Accessions	O14727, O43297, Q7Z438, Q9BXZ6, Q9UBZ5, Q9UGN8, Q9UGN9, Q9UGP0, Q9UJ58, Q9UJ59, Q9UJ60, Q9UJ61, Q9UJ62, Q9UJ63, Q9UJ64, Q9UJ65, Q9UJ66, Q9UJ67, Q9UNC9	Gene names	APAF1, KIAA0413
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

CSK_MOUSE
NC score	0.246324 (rank : 645)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	343
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

BMPR2_HUMAN
NC score	0.245748 (rank : 646)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	534	Target Neighborhood Hits	736	Shared Neighborhood Hits	297
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

WD51B_HUMAN
NC score	0.245718 (rank : 647)	θ value	0.00035302 (rank : 26)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TC44	Gene names	WDR51B
Domain Architecture	No domain graphic available
Description	WD repeat protein 51B.

PLRG1_HUMAN
NC score	0.245412 (rank : 648)	θ value	0.00390308 (rank : 76)
Query Neighborhood Hits	534	Target Neighborhood Hits	318	Shared Neighborhood Hits	143
SwissProt Accessions	O43660, Q8WUD8	Gene names	PLRG1
Domain Architecture
Description	Pleiotropic regulator 1.

BMPR2_MOUSE
NC score	0.245047 (rank : 649)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	534	Target Neighborhood Hits	738	Shared Neighborhood Hits	296
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

PTK6_MOUSE
NC score	0.244345 (rank : 650)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	343
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TNI3K_MOUSE
NC score	0.241996 (rank : 651)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	534	Target Neighborhood Hits	1079	Shared Neighborhood Hits	330
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

IRAK3_HUMAN
NC score	0.241742 (rank : 652)	θ value	0.62314 (rank : 308)
Query Neighborhood Hits	534	Target Neighborhood Hits	644	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
NC score	0.241304 (rank : 653)	θ value	0.0563607 (rank : 148)
Query Neighborhood Hits	534	Target Neighborhood Hits	628	Shared Neighborhood Hits	235
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

APAF_MOUSE
NC score	0.241142 (rank : 654)	θ value	0.00869519 (rank : 93)
Query Neighborhood Hits	534	Target Neighborhood Hits	343	Shared Neighborhood Hits	147
SwissProt Accessions	O88879	Gene names	Apaf1
Domain Architecture
Description	Apoptotic protease-activating factor 1 (Apaf-1).

CSK_HUMAN
NC score	0.240361 (rank : 655)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	343
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TXK_HUMAN
NC score	0.239759 (rank : 656)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	534	Target Neighborhood Hits	971	Shared Neighborhood Hits	339
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TNI3K_HUMAN
NC score	0.239645 (rank : 657)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	534	Target Neighborhood Hits	1084	Shared Neighborhood Hits	334
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TEC_MOUSE
NC score	0.238447 (rank : 658)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	534	Target Neighborhood Hits	1006	Shared Neighborhood Hits	340
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GEMI5_MOUSE
NC score	0.237688 (rank : 659)	θ value	9.29e-05 (rank : 17)
Query Neighborhood Hits	534	Target Neighborhood Hits	424	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BX17	Gene names	Gemin5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

SRPK1_MOUSE
NC score	0.236219 (rank : 660)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	534	Target Neighborhood Hits	639	Shared Neighborhood Hits	303
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
NC score	0.235956 (rank : 661)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	534	Target Neighborhood Hits	664	Shared Neighborhood Hits	299
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

TEC_HUMAN
NC score	0.235760 (rank : 662)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	534	Target Neighborhood Hits	1006	Shared Neighborhood Hits	340
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SRPK1_HUMAN
NC score	0.235755 (rank : 663)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	534	Target Neighborhood Hits	706	Shared Neighborhood Hits	300
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

FER_HUMAN
NC score	0.235680 (rank : 664)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	534	Target Neighborhood Hits	1278	Shared Neighborhood Hits	339
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ABL2_HUMAN
NC score	0.235493 (rank : 665)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	534	Target Neighborhood Hits	1045	Shared Neighborhood Hits	339
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

KSYK_HUMAN
NC score	0.235352 (rank : 666)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	534	Target Neighborhood Hits	901	Shared Neighborhood Hits	339
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ABL1_HUMAN
NC score	0.235131 (rank : 667)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	534	Target Neighborhood Hits	1220	Shared Neighborhood Hits	342
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.235011 (rank : 668)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	534	Target Neighborhood Hits	1178	Shared Neighborhood Hits	341
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TAF5L_HUMAN
NC score	0.234985 (rank : 669)	θ value	0.00665767 (rank : 88)
Query Neighborhood Hits	534	Target Neighborhood Hits	330	Shared Neighborhood Hits	149
SwissProt Accessions	O75529, Q8IW31	Gene names	TAF5L, PAF65B
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

ITK_MOUSE
NC score	0.234856 (rank : 670)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	534	Target Neighborhood Hits	985	Shared Neighborhood Hits	341
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

STRN4_MOUSE
NC score	0.234840 (rank : 671)	θ value	0.0193708 (rank : 110)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	144
SwissProt Accessions	P58404, Q68EF5	Gene names	Strn4, Zin
Domain Architecture
Description	Striatin-4 (Zinedin).

KSYK_MOUSE
NC score	0.234831 (rank : 672)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	534	Target Neighborhood Hits	944	Shared Neighborhood Hits	339
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SRPK2_MOUSE
NC score	0.234543 (rank : 673)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	534	Target Neighborhood Hits	765	Shared Neighborhood Hits	303
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

WDR37_HUMAN
NC score	0.234535 (rank : 674)	θ value	0.0431538 (rank : 142)
Query Neighborhood Hits	534	Target Neighborhood Hits	303	Shared Neighborhood Hits	143
SwissProt Accessions	Q9Y2I8, Q5SW03, Q9NTJ6	Gene names	WDR37, KIAA0982
Domain Architecture
Description	WD repeat protein 37.

LIS1_HUMAN
NC score	0.234426 (rank : 675)	θ value	0.0252991 (rank : 114)
Query Neighborhood Hits	534	Target Neighborhood Hits	333	Shared Neighborhood Hits	147
SwissProt Accessions	P43034, Q8WZ88, Q8WZ89	Gene names	PAFAH1B1, LIS1, MDCR, PAFAHA
Domain Architecture
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

LIS1_MOUSE
NC score	0.234401 (rank : 676)	θ value	0.0252991 (rank : 115)
Query Neighborhood Hits	534	Target Neighborhood Hits	336	Shared Neighborhood Hits	147
SwissProt Accessions	P63005, O35592, P43035, P81692, Q9R2A6	Gene names	Pafah1b1, Lis-1, Lis1, Pafaha
Domain Architecture	No domain graphic available
Description	Platelet-activating factor acetylhydrolase IB subunit alpha (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) (Lissencephaly-1 protein) (LIS-1).

BTK_HUMAN
NC score	0.234257 (rank : 677)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	340
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

WDR37_MOUSE
NC score	0.234255 (rank : 678)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	144
SwissProt Accessions	Q8CBE3, Q80Y96, Q8CCL2	Gene names	Wdr37, Kiaa0982
Domain Architecture
Description	WD repeat protein 37.

ITK_HUMAN
NC score	0.234189 (rank : 679)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	534	Target Neighborhood Hits	1016	Shared Neighborhood Hits	341
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ACVL1_MOUSE
NC score	0.234170 (rank : 680)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	534	Target Neighborhood Hits	739	Shared Neighborhood Hits	321
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

MORG1_HUMAN
NC score	0.234144 (rank : 681)	θ value	0.0193708 (rank : 109)
Query Neighborhood Hits	534	Target Neighborhood Hits	280	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BRX9, Q53FT6	Gene names	MORG1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

FAK1_MOUSE
NC score	0.234128 (rank : 682)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	340
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

BTK_MOUSE
NC score	0.233809 (rank : 683)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	534	Target Neighborhood Hits	1017	Shared Neighborhood Hits	340
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FAK1_HUMAN
NC score	0.233680 (rank : 684)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	534	Target Neighborhood Hits	850	Shared Neighborhood Hits	340
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

STRN4_HUMAN
NC score	0.233033 (rank : 685)	θ value	0.0330416 (rank : 129)
Query Neighborhood Hits	534	Target Neighborhood Hits	325	Shared Neighborhood Hits	144
SwissProt Accessions	Q9NRL3	Gene names	STRN4, ZIN
Domain Architecture
Description	Striatin-4 (Zinedin).

WDR5_HUMAN
NC score	0.232650 (rank : 686)	θ value	0.00228821 (rank : 62)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	148
SwissProt Accessions	P61964, Q91VA5, Q9NWX7, Q9UGP9	Gene names	WDR5, BIG3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein).

WDR5_MOUSE
NC score	0.232650 (rank : 687)	θ value	0.00228821 (rank : 63)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	148
SwissProt Accessions	P61965, Q91VA5, Q922C9, Q9NWX7, Q9UGP9	Gene names	Wdr5, Big, Big3
Domain Architecture
Description	WD repeat protein 5 (BMP2-induced 3-kb gene protein) (WD repeat protein BIG-3).

TAF5L_MOUSE
NC score	0.232584 (rank : 688)	θ value	0.0148317 (rank : 107)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	147
SwissProt Accessions	Q91WQ5, Q8BTL5	Gene names	Taf5l, Paf65b
Domain Architecture
Description	TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65- beta).

SRMS_MOUSE
NC score	0.232281 (rank : 689)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	534	Target Neighborhood Hits	964	Shared Neighborhood Hits	343
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TXK_MOUSE
NC score	0.232162 (rank : 690)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	338
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WDR57_HUMAN
NC score	0.232102 (rank : 691)	θ value	0.0113563 (rank : 103)
Query Neighborhood Hits	534	Target Neighborhood Hits	322	Shared Neighborhood Hits	147
SwissProt Accessions	Q96DI7, O75938, O95320	Gene names	WDR57, PRP8BP, SFP38
Domain Architecture	No domain graphic available
Description	WD repeat protein 57 (Prp8-binding protein) (hPRP8BP) (U5 snRNP- specific 40 kDa protein) (38 kDa-splicing factor).

LYN_HUMAN
NC score	0.232080 (rank : 692)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	534	Target Neighborhood Hits	1022	Shared Neighborhood Hits	343
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BMX_HUMAN
NC score	0.231993 (rank : 693)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	333
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

LYN_MOUSE
NC score	0.231973 (rank : 694)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	343
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BMX_MOUSE
NC score	0.231610 (rank : 695)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	534	Target Neighborhood Hits	912	Shared Neighborhood Hits	334
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

STRN_HUMAN
NC score	0.231411 (rank : 696)	θ value	0.00665767 (rank : 87)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	143
SwissProt Accessions	O43815, Q9NP38	Gene names	STRN
Domain Architecture
Description	Striatin.

MATK_MOUSE
NC score	0.231374 (rank : 697)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	534	Target Neighborhood Hits	952	Shared Neighborhood Hits	342
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

WDR57_MOUSE
NC score	0.230916 (rank : 698)	θ value	0.0193708 (rank : 111)
Query Neighborhood Hits	534	Target Neighborhood Hits	323	Shared Neighborhood Hits	147
SwissProt Accessions	Q6PE01, Q3TEJ3, Q9DCX3	Gene names	Wdr57
Domain Architecture	No domain graphic available
Description	WD repeat protein 57.

SPG16_MOUSE
NC score	0.230579 (rank : 699)	θ value	0.365318 (rank : 274)
Query Neighborhood Hits	534	Target Neighborhood Hits	377	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

SPG16_HUMAN
NC score	0.230494 (rank : 700)	θ value	0.125558 (rank : 193)
Query Neighborhood Hits	534	Target Neighborhood Hits	361	Shared Neighborhood Hits	146
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

MATK_HUMAN
NC score	0.230360 (rank : 701)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	534	Target Neighborhood Hits	954	Shared Neighborhood Hits	342
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

WDR39_HUMAN
NC score	0.230230 (rank : 702)	θ value	0.0330416 (rank : 130)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	143
SwissProt Accessions	O76071	Gene names	WDR39, CIAO1
Domain Architecture
Description	WD repeat protein 39 (Ciao 1 protein).

ZAP70_HUMAN
NC score	0.230140 (rank : 703)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	534	Target Neighborhood Hits	893	Shared Neighborhood Hits	337
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
NC score	0.230109 (rank : 704)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	534	Target Neighborhood Hits	905	Shared Neighborhood Hits	341
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SRMS_HUMAN
NC score	0.229537 (rank : 705)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	534	Target Neighborhood Hits	946	Shared Neighborhood Hits	343
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FAK2_MOUSE
NC score	0.229460 (rank : 706)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	534	Target Neighborhood Hits	851	Shared Neighborhood Hits	336
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ANKK1_MOUSE
NC score	0.228598 (rank : 707)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	534	Target Neighborhood Hits	1072	Shared Neighborhood Hits	335
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

MORG1_MOUSE
NC score	0.228288 (rank : 708)	θ value	0.21417 (rank : 231)
Query Neighborhood Hits	534	Target Neighborhood Hits	281	Shared Neighborhood Hits	139
SwissProt Accessions	Q9DAJ4, Q505C2, Q8VEB7, Q99JX9, Q9D235	Gene names	Morg1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase organizer 1 (MAPK organizer 1).

U3IP2_MOUSE
NC score	0.228055 (rank : 709)	θ value	0.0252991 (rank : 121)
Query Neighborhood Hits	534	Target Neighborhood Hits	312	Shared Neighborhood Hits	143
SwissProt Accessions	Q91WM3, Q8CFB7	Gene names	Rnu3ip2, U3-55k
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

FAK2_HUMAN
NC score	0.227966 (rank : 710)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	337
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MEP50_MOUSE
NC score	0.227584 (rank : 711)	θ value	0.0563607 (rank : 154)
Query Neighborhood Hits	534	Target Neighborhood Hits	271	Shared Neighborhood Hits	132
SwissProt Accessions	Q99J09, Q3TFJ1, Q8BSH8, Q9CZY5	Gene names	Wdr77, Mep50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

WDR1_MOUSE
NC score	0.227476 (rank : 712)	θ value	0.125558 (rank : 194)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	O88342	Gene names	Wdr1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1).

FRK_HUMAN
NC score	0.227346 (rank : 713)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	342
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

RBBP4_MOUSE
NC score	0.227021 (rank : 714)	θ value	0.00869519 (rank : 99)
Query Neighborhood Hits	534	Target Neighborhood Hits	289	Shared Neighborhood Hits	144
SwissProt Accessions	Q60972	Gene names	Rbbp4, Rbap48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

WDR1_HUMAN
NC score	0.226863 (rank : 715)	θ value	0.163984 (rank : 220)
Query Neighborhood Hits	534	Target Neighborhood Hits	292	Shared Neighborhood Hits	143
SwissProt Accessions	O75083, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0	Gene names	WDR1
Domain Architecture
Description	WD repeat protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1).

RBBP4_HUMAN
NC score	0.226586 (rank : 716)	θ value	0.00869519 (rank : 98)
Query Neighborhood Hits	534	Target Neighborhood Hits	291	Shared Neighborhood Hits	145
SwissProt Accessions	Q09028, P31149, Q53H02, Q96BV9	Gene names	RBBP4, RBAP48
Domain Architecture
Description	Histone-binding protein RBBP4 (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome remodeling factor subunit RBAP48).

ACVL1_HUMAN
NC score	0.226361 (rank : 717)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	534	Target Neighborhood Hits	716	Shared Neighborhood Hits	308
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

GEMI5_HUMAN
NC score	0.226238 (rank : 718)	θ value	0.000602161 (rank : 36)
Query Neighborhood Hits	534	Target Neighborhood Hits	362	Shared Neighborhood Hits	141
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

STRN_MOUSE
NC score	0.225622 (rank : 719)	θ value	0.0563607 (rank : 158)
Query Neighborhood Hits	534	Target Neighborhood Hits	326	Shared Neighborhood Hits	145
SwissProt Accessions	O55106	Gene names	Strn
Domain Architecture
Description	Striatin.

TNK1_MOUSE
NC score	0.225607 (rank : 720)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	534	Target Neighborhood Hits	806	Shared Neighborhood Hits	338
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

FYN_HUMAN
NC score	0.225305 (rank : 721)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	534	Target Neighborhood Hits	1078	Shared Neighborhood Hits	343
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

ANKK1_HUMAN
NC score	0.224853 (rank : 722)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	534	Target Neighborhood Hits	1075	Shared Neighborhood Hits	332
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

LCK_MOUSE
NC score	0.224826 (rank : 723)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	534	Target Neighborhood Hits	981	Shared Neighborhood Hits	343
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PRP19_MOUSE
NC score	0.224746 (rank : 724)	θ value	0.21417 (rank : 235)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	146
SwissProt Accessions	Q99KP6, Q3TP64, Q8BKZ5, Q8BVQ4	Gene names	Prpf19, Prp19, Snev
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (Nuclear matrix protein SNEV).

KTNB1_MOUSE
NC score	0.224428 (rank : 725)	θ value	0.47712 (rank : 291)
Query Neighborhood Hits	534	Target Neighborhood Hits	356	Shared Neighborhood Hits	152
SwissProt Accessions	Q8BG40, Q8CD18, Q8R1J0, Q9CWV2	Gene names	Katnb1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

KTNB1_HUMAN
NC score	0.224395 (rank : 726)	θ value	0.47712 (rank : 290)
Query Neighborhood Hits	534	Target Neighborhood Hits	349	Shared Neighborhood Hits	151
SwissProt Accessions	Q9BVA0, O60620	Gene names	KATNB1
Domain Architecture	No domain graphic available
Description	Katanin p80 WD40-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin).

TIE2_HUMAN
NC score	0.224199 (rank : 727)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	534	Target Neighborhood Hits	1192	Shared Neighborhood Hits	342
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

STK23_MOUSE
NC score	0.224103 (rank : 728)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	534	Target Neighborhood Hits	572	Shared Neighborhood Hits	291
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.223748 (rank : 729)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	534	Target Neighborhood Hits	556	Shared Neighborhood Hits	288
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

TIE2_MOUSE
NC score	0.223636 (rank : 730)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	534	Target Neighborhood Hits	1204	Shared Neighborhood Hits	341
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

PRP4_MOUSE
NC score	0.223574 (rank : 731)	θ value	0.163984 (rank : 217)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DAW6	Gene names	Prpf4
Domain Architecture	No domain graphic available
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4).

PRP4_HUMAN
NC score	0.223430 (rank : 732)	θ value	0.163984 (rank : 216)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	144
SwissProt Accessions	O43172, O43445, O43864, Q96DG2, Q96IK4	Gene names	PRPF4, PRP4
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp4 (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) (hPrp4).

FGFR2_MOUSE
NC score	0.223151 (rank : 733)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	534	Target Neighborhood Hits	1062	Shared Neighborhood Hits	342
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PRP19_HUMAN
NC score	0.222967 (rank : 734)	θ value	0.62314 (rank : 318)
Query Neighborhood Hits	534	Target Neighborhood Hits	333	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UMS4	Gene names	PRPF19, NMP200, PRP19
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor 19 (PRP19/PSO4 homolog) (Nuclear matrix protein 200) (hPso4).

BLK_HUMAN
NC score	0.222900 (rank : 735)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	534	Target Neighborhood Hits	994	Shared Neighborhood Hits	343
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FGFR1_MOUSE
NC score	0.222563 (rank : 736)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	534	Target Neighborhood Hits	1068	Shared Neighborhood Hits	344
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.222489 (rank : 737)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	534	Target Neighborhood Hits	1069	Shared Neighborhood Hits	344
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR2_HUMAN
NC score	0.222473 (rank : 738)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	534	Target Neighborhood Hits	1062	Shared Neighborhood Hits	342
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

BLK_MOUSE
NC score	0.222041 (rank : 739)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	534	Target Neighborhood Hits	992	Shared Neighborhood Hits	343
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
NC score	0.221840 (rank : 740)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	534	Target Neighborhood Hits	1035	Shared Neighborhood Hits	343
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FYN_MOUSE
NC score	0.221792 (rank : 741)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	534	Target Neighborhood Hits	1073	Shared Neighborhood Hits	341
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NTRK2_HUMAN
NC score	0.221756 (rank : 742)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	534	Target Neighborhood Hits	1081	Shared Neighborhood Hits	342
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.221530 (rank : 743)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	534	Target Neighborhood Hits	1088	Shared Neighborhood Hits	342
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

TNK1_HUMAN
NC score	0.220853 (rank : 744)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	534	Target Neighborhood Hits	815	Shared Neighborhood Hits	339
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

STRN3_HUMAN
NC score	0.220740 (rank : 745)	θ value	0.21417 (rank : 237)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	144
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

LCK_HUMAN
NC score	0.220677 (rank : 746)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	534	Target Neighborhood Hits	987	Shared Neighborhood Hits	343
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

EPHA5_MOUSE
NC score	0.220488 (rank : 747)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	534	Target Neighborhood Hits	950	Shared Neighborhood Hits	342
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

SRC_MOUSE
NC score	0.220450 (rank : 748)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	534	Target Neighborhood Hits	1033	Shared Neighborhood Hits	341
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRC_HUMAN
NC score	0.219412 (rank : 749)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	534	Target Neighborhood Hits	1058	Shared Neighborhood Hits	341
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

GRWD1_MOUSE
NC score	0.219338 (rank : 750)	θ value	0.163984 (rank : 202)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q810D6, Q922H3	Gene names	Grwd1, A301
Domain Architecture	No domain graphic available
Description	Glutamate-rich WD repeat-containing protein 1 (Protein A301).

HCK_MOUSE
NC score	0.219010 (rank : 751)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	534	Target Neighborhood Hits	1029	Shared Neighborhood Hits	345
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

RET_HUMAN
NC score	0.218982 (rank : 752)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	534	Target Neighborhood Hits	873	Shared Neighborhood Hits	335
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
NC score	0.218932 (rank : 753)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	534	Target Neighborhood Hits	884	Shared Neighborhood Hits	335
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RBBP7_HUMAN
NC score	0.218609 (rank : 754)	θ value	0.0563607 (rank : 156)
Query Neighborhood Hits	534	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q16576	Gene names	RBBP7, RBAP46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

STRN3_MOUSE
NC score	0.218606 (rank : 755)	θ value	0.279714 (rank : 254)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	142
SwissProt Accessions	Q9ERG2	Gene names	Strn3, Gs2na, Sg2na
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

AATK_HUMAN
NC score	0.218499 (rank : 756)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	534	Target Neighborhood Hits	1243	Shared Neighborhood Hits	336
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

RBBP7_MOUSE
NC score	0.218451 (rank : 757)	θ value	0.0563607 (rank : 157)
Query Neighborhood Hits	534	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q60973, Q3UX20	Gene names	Rbbp7, Rbap46
Domain Architecture
Description	Histone-binding protein RBBP7 (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46) (Histone acetyltransferase type B subunit 2) (Nucleosome remodeling factor subunit RBAP46).

GBLP_HUMAN
NC score	0.218376 (rank : 758)	θ value	2.36792 (rank : 410)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	146
SwissProt Accessions	P63244, P25388, P99049	Gene names	GNB2L1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase).

GBLP_MOUSE
NC score	0.218376 (rank : 759)	θ value	2.36792 (rank : 411)
Query Neighborhood Hits	534	Target Neighborhood Hits	316	Shared Neighborhood Hits	146
SwissProt Accessions	P68040, P25388, P99049	Gene names	Gnb2l1, Gnb2-rs1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 2-like 1 (Receptor of activated protein kinase C 1) (RACK1) (Receptor for activated C kinase) (p205) (12-3).

U3IP2_HUMAN
NC score	0.218285 (rank : 760)	θ value	0.365318 (rank : 280)
Query Neighborhood Hits	534	Target Neighborhood Hits	307	Shared Neighborhood Hits	143
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

RIPK4_HUMAN
NC score	0.218155 (rank : 761)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	534	Target Neighborhood Hits	1094	Shared Neighborhood Hits	335
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TAF5_MOUSE
NC score	0.217500 (rank : 762)	θ value	1.06291 (rank : 358)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	145
SwissProt Accessions	Q8C092, Q8BTR2	Gene names	Taf5
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

ERCC8_HUMAN
NC score	0.217435 (rank : 763)	θ value	0.279714 (rank : 241)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	143
SwissProt Accessions	Q13216, Q6FHX5, Q96GB9	Gene names	ERCC8, CKN1, CSA
Domain Architecture
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA).

ACK1_HUMAN
NC score	0.217322 (rank : 764)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	534	Target Neighborhood Hits	1140	Shared Neighborhood Hits	336
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

SMU1_HUMAN
NC score	0.217071 (rank : 765)	θ value	0.813845 (rank : 340)
Query Neighborhood Hits	534	Target Neighborhood Hits	311	Shared Neighborhood Hits	147
SwissProt Accessions	Q2TAY7, Q9BU59, Q9HA96, Q9NVD1	Gene names	SMU1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

SMU1_MOUSE
NC score	0.217071 (rank : 766)	θ value	0.813845 (rank : 341)
Query Neighborhood Hits	534	Target Neighborhood Hits	311	Shared Neighborhood Hits	147
SwissProt Accessions	Q3UKJ7, Q6PFR6, Q8BMY4, Q9D1I8, Q9JJ70	Gene names	Smu1
Domain Architecture	No domain graphic available
Description	Smu-1 suppressor of mec-8 and unc-52 protein homolog.

COPB2_HUMAN
NC score	0.216857 (rank : 767)	θ value	0.813845 (rank : 326)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	145
SwissProt Accessions	P35606	Gene names	COPB2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

UTP15_HUMAN
NC score	0.216832 (rank : 768)	θ value	0.47712 (rank : 303)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q8TED0, Q6IA60, Q96E08, Q9H9F8	Gene names	UTP15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog.

COPB2_MOUSE
NC score	0.216831 (rank : 769)	θ value	0.813845 (rank : 327)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	145
SwissProt Accessions	O55029, Q3U5Z9	Gene names	Copb2
Domain Architecture
Description	Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102).

TAF5_HUMAN
NC score	0.216809 (rank : 770)	θ value	1.38821 (rank : 380)
Query Neighborhood Hits	534	Target Neighborhood Hits	352	Shared Neighborhood Hits	145
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

CDC20_HUMAN
NC score	0.216721 (rank : 771)	θ value	0.0736092 (rank : 160)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	142
SwissProt Accessions	Q12834, Q9BW56, Q9UQI9	Gene names	CDC20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC).

PEX7_HUMAN
NC score	0.216326 (rank : 772)	θ value	0.813845 (rank : 339)
Query Neighborhood Hits	534	Target Neighborhood Hits	275	Shared Neighborhood Hits	143
SwissProt Accessions	O00628	Gene names	PEX7, PTS2R
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

ACV1C_MOUSE
NC score	0.216249 (rank : 773)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	288
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

FBW1B_HUMAN
NC score	0.216188 (rank : 774)	θ value	0.47712 (rank : 286)
Query Neighborhood Hits	534	Target Neighborhood Hits	327	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

FGFR3_HUMAN
NC score	0.215986 (rank : 775)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	534	Target Neighborhood Hits	1042	Shared Neighborhood Hits	342
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

PEX7_MOUSE
NC score	0.215763 (rank : 776)	θ value	1.06291 (rank : 355)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	143
SwissProt Accessions	P97865	Gene names	Pex7
Domain Architecture
Description	Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7).

ACK1_MOUSE
NC score	0.215475 (rank : 777)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	534	Target Neighborhood Hits	1080	Shared Neighborhood Hits	336
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

WDR24_MOUSE
NC score	0.215417 (rank : 778)	θ value	0.00665767 (rank : 89)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	131
SwissProt Accessions	Q8CFJ9	Gene names	Wdr24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

STYK1_HUMAN
NC score	0.215389 (rank : 779)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	534	Target Neighborhood Hits	786	Shared Neighborhood Hits	334
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

YES_HUMAN
NC score	0.215314 (rank : 780)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	534	Target Neighborhood Hits	1059	Shared Neighborhood Hits	341
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ERBB4_HUMAN
NC score	0.215036 (rank : 781)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	534	Target Neighborhood Hits	910	Shared Neighborhood Hits	341
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

YES_MOUSE
NC score	0.214928 (rank : 782)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	534	Target Neighborhood Hits	1052	Shared Neighborhood Hits	341
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHB1_HUMAN
NC score	0.214526 (rank : 783)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	338
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

GRWD1_HUMAN
NC score	0.214458 (rank : 784)	θ value	0.365318 (rank : 260)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	144
SwissProt Accessions	Q9BQ67	Gene names	GRWD1, GRWD, WDR28
Domain Architecture
Description	Glutamate-rich WD repeat-containing protein 1.

COPA_HUMAN
NC score	0.214352 (rank : 785)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	141
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

IF32_MOUSE
NC score	0.214275 (rank : 786)	θ value	0.0961366 (rank : 172)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QZD9	Gene names	Eif3s2, Trip1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

WDR48_HUMAN
NC score	0.214257 (rank : 787)	θ value	0.813845 (rank : 345)
Query Neighborhood Hits	534	Target Neighborhood Hits	291	Shared Neighborhood Hits	144
SwissProt Accessions	Q8TAF3, Q63HJ2, Q658Y1, Q8N3Z1, Q9NSK8, Q9P279	Gene names	WDR48, KIAA1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48 (WD repeat endosomal protein) (p80).

FGFR3_MOUSE
NC score	0.214254 (rank : 788)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	534	Target Neighborhood Hits	1059	Shared Neighborhood Hits	342
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

EPHA3_HUMAN
NC score	0.213857 (rank : 789)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	534	Target Neighborhood Hits	1005	Shared Neighborhood Hits	342
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

WDR48_MOUSE
NC score	0.213818 (rank : 790)	θ value	1.06291 (rank : 361)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BH57, Q80TD4, Q80XI0, Q8BRM0, Q8CBK0, Q922Z9, Q9CRR1, Q9CSL0	Gene names	Wdr48, Kiaa1449
Domain Architecture	No domain graphic available
Description	WD repeat protein 48.

CDC20_MOUSE
NC score	0.213757 (rank : 791)	θ value	0.47712 (rank : 282)
Query Neighborhood Hits	534	Target Neighborhood Hits	325	Shared Neighborhood Hits	145
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

EPHA7_MOUSE
NC score	0.213713 (rank : 792)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	534	Target Neighborhood Hits	1025	Shared Neighborhood Hits	342
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

IF32_HUMAN
NC score	0.213604 (rank : 793)	θ value	0.0961366 (rank : 171)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	124
SwissProt Accessions	Q13347	Gene names	EIF3S2, TRIP1
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 2 (eIF-3 beta) (eIF3 p36) (eIF3i) (TGF-beta receptor-interacting protein 1) (TRIP-1).

TBL3_HUMAN
NC score	0.213457 (rank : 794)	θ value	5.27518 (rank : 486)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	143
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

EGFR_MOUSE
NC score	0.213166 (rank : 795)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	534	Target Neighborhood Hits	927	Shared Neighborhood Hits	340
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

THOC3_MOUSE
NC score	0.213152 (rank : 796)	θ value	1.38821 (rank : 385)
Query Neighborhood Hits	534	Target Neighborhood Hits	296	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VE80, Q9CWI8	Gene names	Thoc3
Domain Architecture
Description	THO complex subunit 3 (Tho3).

EPHA7_HUMAN
NC score	0.213081 (rank : 797)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	534	Target Neighborhood Hits	1053	Shared Neighborhood Hits	342
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

ACV1C_HUMAN
NC score	0.212878 (rank : 798)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	534	Target Neighborhood Hits	709	Shared Neighborhood Hits	287
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

UTP15_MOUSE
NC score	0.212817 (rank : 799)	θ value	3.0926 (rank : 438)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	146
SwissProt Accessions	Q8C7V3, Q3TRG8, Q8K231	Gene names	Utp15
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 15 homolog (Src-associated protein SAW).

EPHA5_HUMAN
NC score	0.212688 (rank : 800)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	342
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

CSTF1_MOUSE
NC score	0.212533 (rank : 801)	θ value	1.38821 (rank : 365)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	137
SwissProt Accessions	Q99LC2, Q3UMB8, Q8BJW1, Q9CSU8	Gene names	Cstf1
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

THOC3_HUMAN
NC score	0.212491 (rank : 802)	θ value	1.38821 (rank : 384)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	142
SwissProt Accessions	Q96J01	Gene names	THOC3
Domain Architecture
Description	THO complex subunit 3 (Tho3) (TEX1 homolog).

EGFR_HUMAN
NC score	0.212362 (rank : 803)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	534	Target Neighborhood Hits	939	Shared Neighborhood Hits	340
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

WDR61_MOUSE
NC score	0.212281 (rank : 804)	θ value	1.81305 (rank : 401)
Query Neighborhood Hits	534	Target Neighborhood Hits	331	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERF3, Q3U562, Q9CZP1	Gene names	Wdr61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

EPHB4_MOUSE
NC score	0.212275 (rank : 805)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	534	Target Neighborhood Hits	1013	Shared Neighborhood Hits	340
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FGR_HUMAN
NC score	0.212231 (rank : 806)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	534	Target Neighborhood Hits	1067	Shared Neighborhood Hits	340
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
NC score	0.212000 (rank : 807)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	534	Target Neighborhood Hits	1069	Shared Neighborhood Hits	341
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

WDR61_HUMAN
NC score	0.211803 (rank : 808)	θ value	2.36792 (rank : 421)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	148
SwissProt Accessions	Q9GZS3, Q6IA22, Q7Z4X4	Gene names	WDR61
Domain Architecture	No domain graphic available
Description	WD repeat protein 61 (Meiotic recombination REC14 protein homolog).

TEP1_HUMAN
NC score	0.211411 (rank : 809)	θ value	0.365318 (rank : 279)
Query Neighborhood Hits	534	Target Neighborhood Hits	371	Shared Neighborhood Hits	148
SwissProt Accessions	Q99973	Gene names	TEP1, TLP1, TP1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog).

CSTF1_HUMAN
NC score	0.211265 (rank : 810)	θ value	0.813845 (rank : 328)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	134
SwissProt Accessions	Q05048	Gene names	CSTF1
Domain Architecture
Description	Cleavage stimulation factor 50 kDa subunit (CSTF 50 kDa subunit) (CF-1 50 kDa subunit) (CstF-50).

EPHA2_MOUSE
NC score	0.210965 (rank : 811)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	534	Target Neighborhood Hits	1020	Shared Neighborhood Hits	338
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

AATK_MOUSE
NC score	0.210719 (rank : 812)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	534	Target Neighborhood Hits	942	Shared Neighborhood Hits	330
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

MET_MOUSE
NC score	0.210688 (rank : 813)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	534	Target Neighborhood Hits	844	Shared Neighborhood Hits	339
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

HIRA_MOUSE
NC score	0.210359 (rank : 814)	θ value	0.163984 (rank : 204)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	133
SwissProt Accessions	Q61666, O08845, Q62365	Gene names	Hira, Tuple1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

MLKL_MOUSE
NC score	0.210318 (rank : 815)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	534	Target Neighborhood Hits	707	Shared Neighborhood Hits	289
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ROR1_MOUSE
NC score	0.210158 (rank : 816)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	534	Target Neighborhood Hits	1025	Shared Neighborhood Hits	336
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

RON_HUMAN
NC score	0.210050 (rank : 817)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	534	Target Neighborhood Hits	842	Shared Neighborhood Hits	340
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

EPHB4_HUMAN
NC score	0.210010 (rank : 818)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	340
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA2_HUMAN
NC score	0.209722 (rank : 819)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	534	Target Neighborhood Hits	1021	Shared Neighborhood Hits	338
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

TIE1_MOUSE
NC score	0.209501 (rank : 820)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	534	Target Neighborhood Hits	1266	Shared Neighborhood Hits	338
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

FGFR4_HUMAN
NC score	0.209430 (rank : 821)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	534	Target Neighborhood Hits	1037	Shared Neighborhood Hits	340
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

ROR1_HUMAN
NC score	0.209402 (rank : 822)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	534	Target Neighborhood Hits	1018	Shared Neighborhood Hits	336
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

EPHA3_MOUSE
NC score	0.209008 (rank : 823)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	534	Target Neighborhood Hits	1009	Shared Neighborhood Hits	342
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

DDR2_MOUSE
NC score	0.208903 (rank : 824)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	534	Target Neighborhood Hits	813	Shared Neighborhood Hits	328
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

MET_HUMAN
NC score	0.208735 (rank : 825)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	534	Target Neighborhood Hits	831	Shared Neighborhood Hits	338
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ERBB2_MOUSE
NC score	0.208248 (rank : 826)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	534	Target Neighborhood Hits	918	Shared Neighborhood Hits	341
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TIE1_HUMAN
NC score	0.208151 (rank : 827)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	534	Target Neighborhood Hits	1241	Shared Neighborhood Hits	337
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

WDR33_HUMAN
NC score	0.207926 (rank : 828)	θ value	0.0252991 (rank : 122)
Query Neighborhood Hits	534	Target Neighborhood Hits	638	Shared Neighborhood Hits	152
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

FBXW7_MOUSE
NC score	0.207638 (rank : 829)	θ value	1.81305 (rank : 392)
Query Neighborhood Hits	534	Target Neighborhood Hits	365	Shared Neighborhood Hits	147
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

TBL2_MOUSE
NC score	0.207573 (rank : 830)	θ value	0.62314 (rank : 323)
Query Neighborhood Hits	534	Target Neighborhood Hits	221	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

EPHA8_HUMAN
NC score	0.207450 (rank : 831)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	534	Target Neighborhood Hits	956	Shared Neighborhood Hits	341
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

HIRA_HUMAN
NC score	0.207420 (rank : 832)	θ value	0.163984 (rank : 203)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	131
SwissProt Accessions	P54198, Q8IXN2	Gene names	HIRA, DGCR1, HIR, TUPLE1
Domain Architecture
Description	HIRA protein (TUP1-like enhancer of split protein 1).

TBL1X_HUMAN
NC score	0.207304 (rank : 833)	θ value	3.0926 (rank : 435)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	146
SwissProt Accessions	O60907, Q86UY2	Gene names	TBL1X, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein) (Transducin-beta-like 1, X-linked) (SMAP55).

ERBB2_HUMAN
NC score	0.207254 (rank : 834)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	534	Target Neighborhood Hits	1073	Shared Neighborhood Hits	342
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHA1_HUMAN
NC score	0.206894 (rank : 835)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	534	Target Neighborhood Hits	997	Shared Neighborhood Hits	334
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

WDR69_HUMAN
NC score	0.206865 (rank : 836)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	142
SwissProt Accessions	Q8N136, Q6ZRY1, Q8N776	Gene names	WDR69
Domain Architecture	No domain graphic available
Description	WD repeat protein 69.

ERCC8_MOUSE
NC score	0.206856 (rank : 837)	θ value	3.0926 (rank : 425)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CFD5, Q3U066, Q8VDC4, Q9CWK7	Gene names	Ercc8, Ckn1, Csa
Domain Architecture	No domain graphic available
Description	DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog).

TBLX_MOUSE
NC score	0.206801 (rank : 838)	θ value	3.0926 (rank : 437)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QXE7, Q8BMM0, Q8BYQ4, Q8C0A1	Gene names	Tbl1x, Tbl1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1X (Transducin beta-like 1X protein).

STRAP_MOUSE
NC score	0.206428 (rank : 839)	θ value	5.27518 (rank : 483)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

STRAP_HUMAN
NC score	0.206280 (rank : 840)	θ value	5.27518 (rank : 482)
Query Neighborhood Hits	534	Target Neighborhood Hits	272	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

FBW1A_HUMAN
NC score	0.205602 (rank : 841)	θ value	4.03905 (rank : 447)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

EPHA4_HUMAN
NC score	0.205573 (rank : 842)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	534	Target Neighborhood Hits	975	Shared Neighborhood Hits	337
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

TBL1Y_HUMAN
NC score	0.205502 (rank : 843)	θ value	3.0926 (rank : 436)
Query Neighborhood Hits	534	Target Neighborhood Hits	331	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BQ87	Gene names	TBL1Y, TBL1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1Y (Transducin beta-like 1Y protein) (Transducin-beta-like 1, Y-linked).

EPHA4_MOUSE
NC score	0.205501 (rank : 844)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	534	Target Neighborhood Hits	982	Shared Neighborhood Hits	337
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

NTRK3_HUMAN
NC score	0.205224 (rank : 845)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	534	Target Neighborhood Hits	1115	Shared Neighborhood Hits	338
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NLE1_MOUSE
NC score	0.204996 (rank : 846)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	148
SwissProt Accessions	Q8VEJ4	Gene names	Nle1
Domain Architecture
Description	Notchless homolog 1.

EPHB2_MOUSE
NC score	0.204942 (rank : 847)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	534	Target Neighborhood Hits	982	Shared Neighborhood Hits	337
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.204879 (rank : 848)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	534	Target Neighborhood Hits	983	Shared Neighborhood Hits	337
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

VRK2_MOUSE
NC score	0.204848 (rank : 849)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	534	Target Neighborhood Hits	586	Shared Neighborhood Hits	286
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

DDR2_HUMAN
NC score	0.204731 (rank : 850)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	327
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

TBL2_HUMAN
NC score	0.204688 (rank : 851)	θ value	1.81305 (rank : 397)
Query Neighborhood Hits	534	Target Neighborhood Hits	225	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

NLE1_HUMAN
NC score	0.204249 (rank : 852)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NVX2, O60868, Q9BU54	Gene names	NLE1
Domain Architecture
Description	Notchless homolog 1.

RON_MOUSE
NC score	0.204194 (rank : 853)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	534	Target Neighborhood Hits	836	Shared Neighborhood Hits	340
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TBL1R_HUMAN
NC score	0.204132 (rank : 854)	θ value	2.36792 (rank : 418)
Query Neighborhood Hits	534	Target Neighborhood Hits	327	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BZK7, Q9H2I1, Q9H9A1	Gene names	TBL1XR1, IRA1, TBLR1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

TBL1R_MOUSE
NC score	0.203930 (rank : 855)	θ value	2.36792 (rank : 419)
Query Neighborhood Hits	534	Target Neighborhood Hits	329	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BHJ5, Q3UWL6, Q8CBG4, Q8VEG3, Q9EQD4	Gene names	Tbl1xr1, Ira1, Tblr1
Domain Architecture
Description	F-box-like/WD repeat protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1).

FBXW7_HUMAN
NC score	0.203596 (rank : 856)	θ value	4.03905 (rank : 448)
Query Neighborhood Hits	534	Target Neighborhood Hits	433	Shared Neighborhood Hits	147
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

TEP1_MOUSE
NC score	0.203395 (rank : 857)	θ value	0.279714 (rank : 256)
Query Neighborhood Hits	534	Target Neighborhood Hits	344	Shared Neighborhood Hits	146
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

MEP50_HUMAN
NC score	0.203208 (rank : 858)	θ value	6.88961 (rank : 501)
Query Neighborhood Hits	534	Target Neighborhood Hits	268	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BQA1, Q96GK4, Q9BWY3	Gene names	WDR77, MEP50
Domain Architecture
Description	Methylosome protein 50 (MEP50 protein) (WD repeat protein 77).

WDR16_MOUSE
NC score	0.202805 (rank : 859)	θ value	0.813845 (rank : 344)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	134
SwissProt Accessions	Q5F201, Q5F200, Q9D432, Q9DA68	Gene names	WDR16
Domain Architecture	No domain graphic available
Description	WD repeat protein 16.

EPHA1_MOUSE
NC score	0.202533 (rank : 860)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	534	Target Neighborhood Hits	958	Shared Neighborhood Hits	332
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

WDR36_HUMAN
NC score	0.202434 (rank : 861)	θ value	2.36792 (rank : 420)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	139
SwissProt Accessions	Q8NI36, Q8N1Q2	Gene names	WDR36
Domain Architecture
Description	WD repeat protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP).

NTRK1_HUMAN
NC score	0.202359 (rank : 862)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	534	Target Neighborhood Hits	1023	Shared Neighborhood Hits	334
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHA8_MOUSE
NC score	0.202252 (rank : 863)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	534	Target Neighborhood Hits	969	Shared Neighborhood Hits	340
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

WSB1_HUMAN
NC score	0.201845 (rank : 864)	θ value	1.81305 (rank : 402)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

WDR3_HUMAN
NC score	0.201763 (rank : 865)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	534	Target Neighborhood Hits	334	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UNX4	Gene names	WDR3
Domain Architecture
Description	WD repeat protein 3.

WSB2_HUMAN
NC score	0.201611 (rank : 866)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	534	Target Neighborhood Hits	308	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

WDR12_MOUSE
NC score	0.201356 (rank : 867)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	534	Target Neighborhood Hits	301	Shared Neighborhood Hits	147
SwissProt Accessions	Q9JJA4, Q9CST3, Q9JKF5	Gene names	Wdr12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

EPHB3_HUMAN
NC score	0.201065 (rank : 868)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	534	Target Neighborhood Hits	996	Shared Neighborhood Hits	337
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
NC score	0.200798 (rank : 869)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	534	Target Neighborhood Hits	996	Shared Neighborhood Hits	337
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

PTK7_HUMAN
NC score	0.200741 (rank : 870)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	328
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

MERTK_MOUSE
NC score	0.200595 (rank : 871)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	534	Target Neighborhood Hits	974	Shared Neighborhood Hits	328
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

WDR12_HUMAN
NC score	0.200593 (rank : 872)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	534	Target Neighborhood Hits	300	Shared Neighborhood Hits	146
SwissProt Accessions	Q9GZL7, Q96HU0, Q9NV80, Q9NYI8	Gene names	WDR12
Domain Architecture
Description	WD repeat protein 12 (YTM1 homolog).

TYRO3_HUMAN
NC score	0.200346 (rank : 873)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	534	Target Neighborhood Hits	995	Shared Neighborhood Hits	326
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

ERBB3_HUMAN
NC score	0.200146 (rank : 874)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	534	Target Neighborhood Hits	918	Shared Neighborhood Hits	332
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

TYRO3_MOUSE
NC score	0.200101 (rank : 875)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	534	Target Neighborhood Hits	1007	Shared Neighborhood Hits	326
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

STYK1_MOUSE
NC score	0.199764 (rank : 876)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	534	Target Neighborhood Hits	779	Shared Neighborhood Hits	328
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

VRK1_MOUSE
NC score	0.199723 (rank : 877)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	534	Target Neighborhood Hits	583	Shared Neighborhood Hits	284
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

WDR31_HUMAN
NC score	0.199202 (rank : 878)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	139
SwissProt Accessions	Q8NA23, Q96EG8	Gene names	WDR31
Domain Architecture
Description	WD repeat protein 31.

AAMP_HUMAN
NC score	0.198976 (rank : 879)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	136
SwissProt Accessions	Q13685, Q8WUJ9, Q96H92	Gene names	AAMP
Domain Architecture
Description	Angio-associated migratory cell protein.

WDR16_HUMAN
NC score	0.198770 (rank : 880)	θ value	1.06291 (rank : 360)
Query Neighborhood Hits	534	Target Neighborhood Hits	275	Shared Neighborhood Hits	132
SwissProt Accessions	Q8N1V2, Q5DX23, Q8TC73, Q8TCI3	Gene names	WDR16, WDRPUH
Domain Architecture	No domain graphic available
Description	WD repeat protein 16 (WD40-repeat protein up-regulated in HCC).

WSB2_MOUSE
NC score	0.198700 (rank : 881)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	534	Target Neighborhood Hits	306	Shared Neighborhood Hits	145
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

WSB1_MOUSE
NC score	0.198437 (rank : 882)	θ value	4.03905 (rank : 465)
Query Neighborhood Hits	534	Target Neighborhood Hits	313	Shared Neighborhood Hits	148
SwissProt Accessions	O54927	Gene names	Wsb1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1).

FGFR4_MOUSE
NC score	0.198303 (rank : 883)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	534	Target Neighborhood Hits	1026	Shared Neighborhood Hits	339
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

PRP17_HUMAN
NC score	0.198250 (rank : 884)	θ value	8.99809 (rank : 530)
Query Neighborhood Hits	534	Target Neighborhood Hits	297	Shared Neighborhood Hits	145
SwissProt Accessions	O60508, O75471, Q9UPG1	Gene names	CDC40, PRP17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (hPRP17) (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3).

ROR2_HUMAN
NC score	0.198166 (rank : 885)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	534	Target Neighborhood Hits	1014	Shared Neighborhood Hits	338
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ERBB3_MOUSE
NC score	0.198033 (rank : 886)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	534	Target Neighborhood Hits	898	Shared Neighborhood Hits	336
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ROS_HUMAN
NC score	0.197916 (rank : 887)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	534	Target Neighborhood Hits	907	Shared Neighborhood Hits	325
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

PRP17_MOUSE
NC score	0.196608 (rank : 888)	θ value	8.99809 (rank : 531)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	145
SwissProt Accessions	Q9DC48	Gene names	Cdc40, Prp17
Domain Architecture
Description	Pre-mRNA-splicing factor PRP17 (Cell division cycle 40 homolog).

VRK1_HUMAN
NC score	0.196596 (rank : 889)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	534	Target Neighborhood Hits	584	Shared Neighborhood Hits	288
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

PK1IP_MOUSE
NC score	0.196547 (rank : 890)	θ value	3.0926 (rank : 432)
Query Neighborhood Hits	534	Target Neighborhood Hits	313	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

TOPK_MOUSE
NC score	0.195914 (rank : 891)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	534	Target Neighborhood Hits	618	Shared Neighborhood Hits	232
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

VRK2_HUMAN
NC score	0.195545 (rank : 892)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	534	Target Neighborhood Hits	582	Shared Neighborhood Hits	278
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

WDR31_MOUSE
NC score	0.194783 (rank : 893)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	534	Target Neighborhood Hits	287	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JHB4, Q3URZ0, Q9D3N4	Gene names	Wdr31
Domain Architecture
Description	WD repeat protein 31 (Spermatid WD repeat protein) (spWD).

INSR_HUMAN
NC score	0.194667 (rank : 894)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	534	Target Neighborhood Hits	963	Shared Neighborhood Hits	343
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

UFO_MOUSE
NC score	0.194091 (rank : 895)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	318
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

NTKL_MOUSE
NC score	0.193648 (rank : 896)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	534	Target Neighborhood Hits	326	Shared Neighborhood Hits	151
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

INSR_MOUSE
NC score	0.193491 (rank : 897)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	534	Target Neighborhood Hits	968	Shared Neighborhood Hits	338
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

BRWD1_HUMAN
NC score	0.193116 (rank : 898)	θ value	0.47712 (rank : 281)
Query Neighborhood Hits	534	Target Neighborhood Hits	448	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

PLAP_HUMAN
NC score	0.192664 (rank : 899)	θ value	3.0926 (rank : 433)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	139
SwissProt Accessions	Q9Y263, Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1	Gene names	PLAA, PLAP
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP) (PLA2P).

UFO_HUMAN
NC score	0.192649 (rank : 900)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	534	Target Neighborhood Hits	981	Shared Neighborhood Hits	318
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

MERTK_HUMAN
NC score	0.192639 (rank : 901)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	534	Target Neighborhood Hits	988	Shared Neighborhood Hits	332
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

WDR17_HUMAN
NC score	0.191299 (rank : 902)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	534	Target Neighborhood Hits	335	Shared Neighborhood Hits	142
SwissProt Accessions	Q8IZU2	Gene names	WDR17
Domain Architecture
Description	WD repeat protein 17.

A16L1_HUMAN
NC score	0.190712 (rank : 903)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	534	Target Neighborhood Hits	664	Shared Neighborhood Hits	159
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

BRWD1_MOUSE
NC score	0.190391 (rank : 904)	θ value	1.06291 (rank : 346)
Query Neighborhood Hits	534	Target Neighborhood Hits	478	Shared Neighborhood Hits	149
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

PWP2_HUMAN
NC score	0.189086 (rank : 905)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	142
SwissProt Accessions	Q15269, Q96A77	Gene names	PWP2H, PWP2
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

DDR1_MOUSE
NC score	0.188596 (rank : 906)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	534	Target Neighborhood Hits	818	Shared Neighborhood Hits	325
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

WDR71_HUMAN
NC score	0.188401 (rank : 907)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	534	Target Neighborhood Hits	241	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BRP4, Q4G165, Q53HS9, Q7Z500, Q8TBU6, Q9HAB6	Gene names	WDR71
Domain Architecture	No domain graphic available
Description	WD repeat protein 71 (Protein G-16).

PLAP_MOUSE
NC score	0.188299 (rank : 908)	θ value	8.99809 (rank : 529)
Query Neighborhood Hits	534	Target Neighborhood Hits	261	Shared Neighborhood Hits	140
SwissProt Accessions	P27612, Q8C6C4	Gene names	Plaa, Plap
Domain Architecture
Description	Phospholipase A-2-activating protein (PLAP).

PK1IP_HUMAN
NC score	0.188125 (rank : 909)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	534	Target Neighborhood Hits	277	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NWT1, Q5T4J2, Q96QJ8, Q96T87	Gene names	PAK1IP1, PIP1, WDR84
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (PAK/PLC-interacting protein 1) (hPIP1) (WD repeat protein 84).

VGFR1_MOUSE
NC score	0.188034 (rank : 910)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	534	Target Neighborhood Hits	1118	Shared Neighborhood Hits	340
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

DDR1_HUMAN
NC score	0.187522 (rank : 911)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	534	Target Neighborhood Hits	819	Shared Neighborhood Hits	327
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

VGFR3_MOUSE
NC score	0.187363 (rank : 912)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	534	Target Neighborhood Hits	1056	Shared Neighborhood Hits	339
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WDR47_MOUSE
NC score	0.186780 (rank : 913)	θ value	5.27518 (rank : 491)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	135
SwissProt Accessions	Q8CGF6, Q80TP4	Gene names	Wdr47, Kiaa0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

GBB5_MOUSE
NC score	0.186459 (rank : 914)	θ value	5.27518 (rank : 470)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	143
SwissProt Accessions	P62881, O35354, P54314, Q91WB3	Gene names	Gnb5
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

GBB5_HUMAN
NC score	0.186219 (rank : 915)	θ value	5.27518 (rank : 469)
Query Neighborhood Hits	534	Target Neighborhood Hits	299	Shared Neighborhood Hits	144
SwissProt Accessions	O14775, Q9HAU9	Gene names	GNB5
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 5 (Transducin beta chain 5) (Gbeta5).

MUSK_HUMAN
NC score	0.186168 (rank : 916)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	534	Target Neighborhood Hits	1074	Shared Neighborhood Hits	333
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

EPHA6_MOUSE
NC score	0.185853 (rank : 917)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	534	Target Neighborhood Hits	946	Shared Neighborhood Hits	342
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

A16L1_MOUSE
NC score	0.185531 (rank : 918)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	534	Target Neighborhood Hits	776	Shared Neighborhood Hits	159
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

PWP2_MOUSE
NC score	0.185217 (rank : 919)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	534	Target Neighborhood Hits	309	Shared Neighborhood Hits	141
SwissProt Accessions	Q8BU03, Q8BTR0	Gene names	Pwp2h
Domain Architecture
Description	Periodic tryptophan protein 2 homolog.

VGFR3_HUMAN
NC score	0.185115 (rank : 920)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	534	Target Neighborhood Hits	1037	Shared Neighborhood Hits	339
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WDR47_HUMAN
NC score	0.185058 (rank : 921)	θ value	5.27518 (rank : 490)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	133
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

MUSK_MOUSE
NC score	0.184989 (rank : 922)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	534	Target Neighborhood Hits	1057	Shared Neighborhood Hits	333
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

RBBP5_HUMAN
NC score	0.184840 (rank : 923)	θ value	0.125558 (rank : 192)
Query Neighborhood Hits	534	Target Neighborhood Hits	372	Shared Neighborhood Hits	107
SwissProt Accessions	Q15291	Gene names	RBBP5, RBQ3
Domain Architecture
Description	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3).

EPHA6_HUMAN
NC score	0.184101 (rank : 924)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	534	Target Neighborhood Hits	959	Shared Neighborhood Hits	342
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TOPK_HUMAN
NC score	0.184082 (rank : 925)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	534	Target Neighborhood Hits	605	Shared Neighborhood Hits	216
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ROR2_MOUSE
NC score	0.183915 (rank : 926)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	534	Target Neighborhood Hits	1000	Shared Neighborhood Hits	331
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

FZR_MOUSE
NC score	0.183835 (rank : 927)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R1K5	Gene names	Fzr1, Fyr, Fzr
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog).

VGFR1_HUMAN
NC score	0.183818 (rank : 928)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	534	Target Neighborhood Hits	1109	Shared Neighborhood Hits	338
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

FZR_HUMAN
NC score	0.183712 (rank : 929)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	534	Target Neighborhood Hits	279	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UM11, O75869, Q86U66, Q96NW8, Q9UI96, Q9ULH8, Q9UM10, Q9UNQ1, Q9Y2T8	Gene names	FZR1, CDH1, FYR, FZR, KIAA1242
Domain Architecture
Description	Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) (hCDH1) (CDC20-like protein 1).

INSRR_MOUSE
NC score	0.183617 (rank : 930)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	534	Target Neighborhood Hits	961	Shared Neighborhood Hits	334
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

VGFR2_MOUSE
NC score	0.183122 (rank : 931)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	534	Target Neighborhood Hits	1089	Shared Neighborhood Hits	339
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

INSRR_HUMAN
NC score	0.182498 (rank : 932)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	534	Target Neighborhood Hits	950	Shared Neighborhood Hits	336
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

VGFR2_HUMAN
NC score	0.182068 (rank : 933)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	339
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

PGFRA_HUMAN
NC score	0.181524 (rank : 934)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	534	Target Neighborhood Hits	980	Shared Neighborhood Hits	335
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
NC score	0.181057 (rank : 935)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	534	Target Neighborhood Hits	975	Shared Neighborhood Hits	334
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

WDR23_MOUSE
NC score	0.180890 (rank : 936)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	534	Target Neighborhood Hits	271	Shared Neighborhood Hits	142
SwissProt Accessions	Q91VU6, Q3U836, Q8JZV8	Gene names	Wdr23, D14Ucla1
Domain Architecture
Description	WD repeat protein 23.

WDR26_HUMAN
NC score	0.180835 (rank : 937)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	137
SwissProt Accessions	Q9H7D7, Q86UY4	Gene names	WDR26
Domain Architecture
Description	WD repeat protein 26.

IGF1R_MOUSE
NC score	0.180677 (rank : 938)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	534	Target Neighborhood Hits	973	Shared Neighborhood Hits	335
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

WDR26_MOUSE
NC score	0.180583 (rank : 939)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	137
SwissProt Accessions	Q8C6G8, Q8C4F3, Q8VDZ6	Gene names	Wdr26
Domain Architecture
Description	WD repeat protein 26.

WDR79_MOUSE
NC score	0.179933 (rank : 940)	θ value	1.38821 (rank : 390)
Query Neighborhood Hits	534	Target Neighborhood Hits	216	Shared Neighborhood Hits	114
SwissProt Accessions	Q8VC51	Gene names	Wdr79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

IGF1R_HUMAN
NC score	0.179892 (rank : 941)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	534	Target Neighborhood Hits	977	Shared Neighborhood Hits	337
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

WDR23_HUMAN
NC score	0.178422 (rank : 942)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TEB1, Q86U00, Q86U39, Q8NDN2, Q9H2J0, Q9H3A3, Q9H5C9	Gene names	WDR23
Domain Architecture
Description	WD repeat protein 23.

FBXW2_MOUSE
NC score	0.178213 (rank : 943)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	534	Target Neighborhood Hits	249	Shared Neighborhood Hits	130
SwissProt Accessions	Q60584	Gene names	Fbxw2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

PGFRB_MOUSE
NC score	0.177931 (rank : 944)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	534	Target Neighborhood Hits	960	Shared Neighborhood Hits	336
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PWP1_MOUSE
NC score	0.177567 (rank : 945)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	534	Target Neighborhood Hits	278	Shared Neighborhood Hits	138
SwissProt Accessions	Q99LL5, Q9D6T6	Gene names	Pwp1
Domain Architecture	No domain graphic available
Description	Periodic tryptophan protein 1 homolog.

PGFRB_HUMAN
NC score	0.177559 (rank : 946)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	534	Target Neighborhood Hits	962	Shared Neighborhood Hits	335
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CAF1B_HUMAN
NC score	0.177492 (rank : 947)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	534	Target Neighborhood Hits	345	Shared Neighborhood Hits	137
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

AMHR2_HUMAN
NC score	0.177482 (rank : 948)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	283
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

CAF1B_MOUSE
NC score	0.177372 (rank : 949)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	534	Target Neighborhood Hits	385	Shared Neighborhood Hits	138
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

KIT_MOUSE
NC score	0.177250 (rank : 950)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	534	Target Neighborhood Hits	949	Shared Neighborhood Hits	332
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_HUMAN
NC score	0.176779 (rank : 951)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	534	Target Neighborhood Hits	953	Shared Neighborhood Hits	330
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FBXW2_HUMAN
NC score	0.176240 (rank : 952)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	534	Target Neighborhood Hits	260	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FLT3_HUMAN
NC score	0.176038 (rank : 953)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	534	Target Neighborhood Hits	843	Shared Neighborhood Hits	332
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

GBB1_HUMAN
NC score	0.175180 (rank : 954)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62873, P04697, P04901	Gene names	GNB1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

GBB1_MOUSE
NC score	0.175180 (rank : 955)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62874, P04697, P04901	Gene names	Gnb1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 1 (Transducin beta chain 1).

WDR75_HUMAN
NC score	0.175052 (rank : 956)	θ value	2.36792 (rank : 422)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IWA0, Q96J10, Q9H8U8, Q9H9U5, Q9H9V8, Q9UIX2	Gene names	WDR75
Domain Architecture	No domain graphic available
Description	WD repeat protein 75.

GBB4_MOUSE
NC score	0.174788 (rank : 957)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	137
SwissProt Accessions	P29387, Q3TJJ1, Q8R475, Q9JHX8	Gene names	Gnb4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

GBB4_HUMAN
NC score	0.174779 (rank : 958)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	534	Target Neighborhood Hits	288	Shared Neighborhood Hits	139
SwissProt Accessions	Q9HAV0	Gene names	GNB4
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta 4 (Transducin beta chain 4).

FLT3_MOUSE
NC score	0.174645 (rank : 959)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	534	Target Neighborhood Hits	847	Shared Neighborhood Hits	334
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

WDR22_MOUSE
NC score	0.174256 (rank : 960)	θ value	4.03905 (rank : 462)
Query Neighborhood Hits	534	Target Neighborhood Hits	302	Shared Neighborhood Hits	126
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

GBB2_HUMAN
NC score	0.173604 (rank : 961)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62879, P11016, P54312	Gene names	GNB2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

GBB2_MOUSE
NC score	0.173604 (rank : 962)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	P62880, P11016, P54312	Gene names	Gnb2
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit).

BUB1_HUMAN
NC score	0.173184 (rank : 963)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	534	Target Neighborhood Hits	543	Shared Neighborhood Hits	216
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

WDR79_HUMAN
NC score	0.173042 (rank : 964)	θ value	2.36792 (rank : 423)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BUR4, Q9NW09	Gene names	WDR79
Domain Architecture	No domain graphic available
Description	WD repeat protein 79.

WDR53_MOUSE
NC score	0.172566 (rank : 965)	θ value	3.0926 (rank : 439)
Query Neighborhood Hits	534	Target Neighborhood Hits	254	Shared Neighborhood Hits	130
SwissProt Accessions	Q9DB94	Gene names	Wdr53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

PWP1_HUMAN
NC score	0.172149 (rank : 966)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	534	Target Neighborhood Hits	261	Shared Neighborhood Hits	129
SwissProt Accessions	Q13610	Gene names	PWP1
Domain Architecture
Description	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502).

GBB3_HUMAN
NC score	0.172131 (rank : 967)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	135
SwissProt Accessions	P16520, Q9BQC0	Gene names	GNB3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

WDR22_HUMAN
NC score	0.171651 (rank : 968)	θ value	6.88961 (rank : 510)
Query Neighborhood Hits	534	Target Neighborhood Hits	328	Shared Neighborhood Hits	125
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

FAN_HUMAN
NC score	0.171604 (rank : 969)	θ value	1.06291 (rank : 349)
Query Neighborhood Hits	534	Target Neighborhood Hits	295	Shared Neighborhood Hits	140
SwissProt Accessions	Q92636	Gene names	NSMAF, FAN
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

GBB3_MOUSE
NC score	0.171480 (rank : 970)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	534	Target Neighborhood Hits	283	Shared Neighborhood Hits	136
SwissProt Accessions	Q61011	Gene names	Gnb3
Domain Architecture
Description	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 3 (Transducin beta chain 3).

ALK_HUMAN
NC score	0.171176 (rank : 971)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	534	Target Neighborhood Hits	795	Shared Neighborhood Hits	309
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
NC score	0.170561 (rank : 972)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	534	Target Neighborhood Hits	811	Shared Neighborhood Hits	313
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

WDR18_HUMAN
NC score	0.170474 (rank : 973)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	130
SwissProt Accessions	Q9BV38, O60390, Q9BWR2	Gene names	WDR18
Domain Architecture
Description	WD repeat protein 18.

FAN_MOUSE
NC score	0.169009 (rank : 974)	θ value	1.06291 (rank : 350)
Query Neighborhood Hits	534	Target Neighborhood Hits	292	Shared Neighborhood Hits	138
SwissProt Accessions	O35242	Gene names	Nsmaf, Fan
Domain Architecture
Description	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation).

TRAF7_MOUSE
NC score	0.168246 (rank : 975)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	534	Target Neighborhood Hits	470	Shared Neighborhood Hits	134
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

GUC2F_HUMAN
NC score	0.168228 (rank : 976)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	534	Target Neighborhood Hits	740	Shared Neighborhood Hits	294
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

WDR53_HUMAN
NC score	0.168067 (rank : 977)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	534	Target Neighborhood Hits	251	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z5U6	Gene names	WDR53
Domain Architecture	No domain graphic available
Description	WD repeat protein 53.

TRAF7_HUMAN
NC score	0.167145 (rank : 978)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	534	Target Neighborhood Hits	482	Shared Neighborhood Hits	132
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

LTK_MOUSE
NC score	0.167042 (rank : 979)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	534	Target Neighborhood Hits	770	Shared Neighborhood Hits	302
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

WDR18_MOUSE
NC score	0.166903 (rank : 980)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	131
SwissProt Accessions	Q4VBE8	Gene names	Wdr18
Domain Architecture	No domain graphic available
Description	WD repeat protein 18.

LTK_HUMAN
NC score	0.166302 (rank : 981)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	534	Target Neighborhood Hits	774	Shared Neighborhood Hits	310
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

FBXW4_MOUSE
NC score	0.165780 (rank : 982)	θ value	1.38821 (rank : 366)
Query Neighborhood Hits	534	Target Neighborhood Hits	205	Shared Neighborhood Hits	109
SwissProt Accessions	Q9JMJ2, Q9QXW3	Gene names	Fbxw4, Fbw4
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Hagoromo protein).

WDR49_HUMAN
NC score	0.165215 (rank : 983)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IV35, Q8N297	Gene names	WDR49
Domain Architecture	No domain graphic available
Description	WD repeat protein 49.

EPHAA_HUMAN
NC score	0.164450 (rank : 984)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	534	Target Neighborhood Hits	960	Shared Neighborhood Hits	315
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

WDR65_HUMAN
NC score	0.163046 (rank : 985)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	534	Target Neighborhood Hits	238	Shared Neighborhood Hits	124
SwissProt Accessions	Q96MR6, Q5TAI0	Gene names	WDR65
Domain Architecture	No domain graphic available
Description	WD repeat protein 65.

GNB1L_MOUSE
NC score	0.161190 (rank : 986)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	534	Target Neighborhood Hits	231	Shared Neighborhood Hits	123
SwissProt Accessions	Q9EQ15, Q8R1F3, Q9CWP2, Q9D3Y1	Gene names	Gnb1l, Estm55, Wdr14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF).

NRBP_HUMAN
NC score	0.158648 (rank : 987)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	534	Target Neighborhood Hits	448	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

AHI1_MOUSE
NC score	0.158080 (rank : 988)	θ value	0.279714 (rank : 240)
Query Neighborhood Hits	534	Target Neighborhood Hits	496	Shared Neighborhood Hits	137
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CSF1R_MOUSE
NC score	0.157532 (rank : 989)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	534	Target Neighborhood Hits	983	Shared Neighborhood Hits	329
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

NTKL_HUMAN
NC score	0.157338 (rank : 990)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	534	Target Neighborhood Hits	266	Shared Neighborhood Hits	124
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

BUB3_HUMAN
NC score	0.156808 (rank : 991)	θ value	6.88961 (rank : 493)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	115
SwissProt Accessions	O43684, O43685	Gene names	BUB3
Domain Architecture
Description	Mitotic checkpoint protein BUB3.

WDR6_HUMAN
NC score	0.156793 (rank : 992)	θ value	4.03905 (rank : 464)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NNW5, Q9UF63	Gene names	WDR6
Domain Architecture
Description	WD repeat protein 6.

CSF1R_HUMAN
NC score	0.156655 (rank : 993)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	534	Target Neighborhood Hits	943	Shared Neighborhood Hits	331
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FBXW4_HUMAN
NC score	0.156566 (rank : 994)	θ value	2.36792 (rank : 409)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	106
SwissProt Accessions	P57775, Q5SVS1, Q96IM6	Gene names	FBXW4, FBW4, SHFM3
Domain Architecture
Description	F-box/WD repeat protein 4 (F-box and WD-40 domain protein 4) (Dactylin).

WDR43_HUMAN
NC score	0.156415 (rank : 995)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	534	Target Neighborhood Hits	269	Shared Neighborhood Hits	108
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

WDHD1_MOUSE
NC score	0.156319 (rank : 996)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	534	Target Neighborhood Hits	414	Shared Neighborhood Hits	135
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

GUC2D_HUMAN
NC score	0.156132 (rank : 997)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	284
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

BUB3_MOUSE
NC score	0.155966 (rank : 998)	θ value	6.88961 (rank : 494)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	116
SwissProt Accessions	Q9WVA3, P97397	Gene names	Bub3
Domain Architecture
Description	Mitotic checkpoint protein BUB3 (WD repeat type I transmembrane protein A72.5).

WDR55_MOUSE
NC score	0.155793 (rank : 999)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	534	Target Neighborhood Hits	236	Shared Neighborhood Hits	113
SwissProt Accessions	Q9CX97	Gene names	Wdr55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

FBXW5_MOUSE
NC score	0.153978 (rank : 1000)	θ value	0.47712 (rank : 287)
Query Neighborhood Hits	534	Target Neighborhood Hits	159	Shared Neighborhood Hits	99
SwissProt Accessions	Q9QXW2	Gene names	Fbxw5, Fbw5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

NRBP_MOUSE
NC score	0.153941 (rank : 1001)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	534	Target Neighborhood Hits	442	Shared Neighborhood Hits	155
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

RFWD2_HUMAN
NC score	0.153857 (rank : 1002)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	534	Target Neighborhood Hits	518	Shared Neighborhood Hits	132
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
NC score	0.153839 (rank : 1003)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	534	Target Neighborhood Hits	535	Shared Neighborhood Hits	134
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RYK_MOUSE
NC score	0.152746 (rank : 1004)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	534	Target Neighborhood Hits	715	Shared Neighborhood Hits	292
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

WDR55_HUMAN
NC score	0.152618 (rank : 1005)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	534	Target Neighborhood Hits	231	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6Y2	Gene names	WDR55
Domain Architecture	No domain graphic available
Description	WD repeat protein 55.

MLKL_HUMAN
NC score	0.152561 (rank : 1006)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	534	Target Neighborhood Hits	600	Shared Neighborhood Hits	203
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

NEDD1_MOUSE
NC score	0.151822 (rank : 1007)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	534	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

IF122_HUMAN
NC score	0.151594 (rank : 1008)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	534	Target Neighborhood Hits	244	Shared Neighborhood Hits	122
SwissProt Accessions	Q9HBG6	Gene names	IFT122, WDR10, WDR140
Domain Architecture
Description	Intraflagellar transport 122 homolog (WD repeat protein 10).

EPHB6_MOUSE
NC score	0.150941 (rank : 1009)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	534	Target Neighborhood Hits	906	Shared Neighborhood Hits	286
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

NEDD1_HUMAN
NC score	0.150612 (rank : 1010)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	124
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

RAE1L_MOUSE
NC score	0.150416 (rank : 1011)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	534	Target Neighborhood Hits	225	Shared Neighborhood Hits	125
SwissProt Accessions	Q8C570, Q3UKD4	Gene names	Rae1, Mrnp41
Domain Architecture	No domain graphic available
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

RAE1L_HUMAN
NC score	0.150027 (rank : 1012)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	534	Target Neighborhood Hits	222	Shared Neighborhood Hits	126
SwissProt Accessions	P78406, O15306, Q3SYL7, Q5TCH8, Q6V708, Q9H100, Q9NQM6	Gene names	RAE1, MRNP41
Domain Architecture
Description	mRNA-associated protein mrnp 41 (Rae1 protein homolog).

WDHD1_HUMAN
NC score	0.149717 (rank : 1013)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	129
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

WDFY1_HUMAN
NC score	0.149673 (rank : 1014)	θ value	5.27518 (rank : 488)
Query Neighborhood Hits	534	Target Neighborhood Hits	305	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

BOP1_MOUSE
NC score	0.149005 (rank : 1015)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	130
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

SEH1L_HUMAN
NC score	0.148941 (rank : 1016)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	534	Target Neighborhood Hits	145	Shared Neighborhood Hits	90
SwissProt Accessions	Q96EE3, Q8NFU6, Q96MH3, Q9C069	Gene names	SEH1L, SEC13L, SEH1
Domain Architecture
Description	Nucleoporin SEH1-like (SEC13-like protein).

EPHB6_HUMAN
NC score	0.148286 (rank : 1017)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	534	Target Neighborhood Hits	912	Shared Neighborhood Hits	276
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

GUC2G_MOUSE
NC score	0.147498 (rank : 1018)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	534	Target Neighborhood Hits	644	Shared Neighborhood Hits	252
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

STTP1_MOUSE
NC score	0.147097 (rank : 1019)	θ value	8.99809 (rank : 533)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	128
SwissProt Accessions	Q91WG4, Q3TIH5, Q3TIT0, Q8CBW6, Q9ESY7	Gene names	Statip1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1).

TLE2_HUMAN
NC score	0.146882 (rank : 1020)	θ value	1.38821 (rank : 387)
Query Neighborhood Hits	534	Target Neighborhood Hits	321	Shared Neighborhood Hits	139
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

TEX14_MOUSE
NC score	0.146134 (rank : 1021)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	534	Target Neighborhood Hits	1333	Shared Neighborhood Hits	269
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

WDR24_HUMAN
NC score	0.145885 (rank : 1022)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	534	Target Neighborhood Hits	247	Shared Neighborhood Hits	120
SwissProt Accessions	Q96S15, Q96GC7, Q9H0B7	Gene names	WDR24
Domain Architecture	No domain graphic available
Description	WD repeat protein 24.

TLE4_HUMAN
NC score	0.145657 (rank : 1023)	θ value	1.81305 (rank : 399)
Query Neighborhood Hits	534	Target Neighborhood Hits	477	Shared Neighborhood Hits	140
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

TLE4_MOUSE
NC score	0.145586 (rank : 1024)	θ value	1.81305 (rank : 400)
Query Neighborhood Hits	534	Target Neighborhood Hits	482	Shared Neighborhood Hits	140
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

2AAA_HUMAN
NC score	0.145149 (rank : 1025)	θ value	0.00298849 (rank : 64)
Query Neighborhood Hits	534	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	P30153, Q13773	Gene names	PPP2R1A
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform) (Medium tumor antigen-associated 61 kDa protein).

FBXW9_HUMAN
NC score	0.145008 (rank : 1026)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	534	Target Neighborhood Hits	184	Shared Neighborhood Hits	108
SwissProt Accessions	Q5XUX1, Q9BT89	Gene names	FBXW9, FBW9
Domain Architecture	No domain graphic available
Description	F-box/WD repeat protein 9 (F-box and WD-40 domain protein 9).

SEC13_MOUSE
NC score	0.143969 (rank : 1027)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D1M0, Q99M12, Q9D712	Gene names	Sec13l1
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

GNB1L_HUMAN
NC score	0.143864 (rank : 1028)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	534	Target Neighborhood Hits	221	Shared Neighborhood Hits	113
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

ANPRB_HUMAN
NC score	0.143014 (rank : 1029)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	534	Target Neighborhood Hits	646	Shared Neighborhood Hits	222
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

RN5A_MOUSE
NC score	0.142851 (rank : 1030)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	534	Target Neighborhood Hits	899	Shared Neighborhood Hits	298
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RYK_HUMAN
NC score	0.142711 (rank : 1031)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	534	Target Neighborhood Hits	701	Shared Neighborhood Hits	287
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

GUC2E_MOUSE
NC score	0.142701 (rank : 1032)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	534	Target Neighborhood Hits	692	Shared Neighborhood Hits	274
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

THOC6_HUMAN
NC score	0.142205 (rank : 1033)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	534	Target Neighborhood Hits	223	Shared Neighborhood Hits	124
SwissProt Accessions	Q86W42, Q8NBR1, Q9BTV9	Gene names	THOC6, WDR58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

TLE2_MOUSE
NC score	0.141481 (rank : 1034)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	534	Target Neighborhood Hits	294	Shared Neighborhood Hits	135
SwissProt Accessions	Q9WVB2	Gene names	Tle2, Grg2
Domain Architecture
Description	Transducin-like enhancer protein 2.

STK31_HUMAN
NC score	0.141440 (rank : 1035)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	534	Target Neighborhood Hits	570	Shared Neighborhood Hits	177
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

SEC13_HUMAN
NC score	0.141401 (rank : 1036)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	99
SwissProt Accessions	P55735, Q9BRM6, Q9BUG7	Gene names	SEC13L1, SEC13R
Domain Architecture	No domain graphic available
Description	SEC13-related protein (SEC13-like protein 1).

2AAA_MOUSE
NC score	0.141140 (rank : 1037)	θ value	0.00665767 (rank : 80)
Query Neighborhood Hits	534	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q76MZ3	Gene names	Ppp2r1a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A, subunit A, PR65-alpha isoform) (PP2A, subunit A, R1-alpha isoform).

SCAP_HUMAN
NC score	0.140891 (rank : 1038)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	534	Target Neighborhood Hits	368	Shared Neighborhood Hits	114
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

ZF106_HUMAN
NC score	0.140655 (rank : 1039)	θ value	8.99809 (rank : 534)
Query Neighborhood Hits	534	Target Neighborhood Hits	470	Shared Neighborhood Hits	117
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

WDTC1_HUMAN
NC score	0.139640 (rank : 1040)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	534	Target Neighborhood Hits	299	Shared Neighborhood Hits	133
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDTC1_MOUSE
NC score	0.139126 (rank : 1041)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	534	Target Neighborhood Hits	298	Shared Neighborhood Hits	134
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDFY2_MOUSE
NC score	0.138785 (rank : 1042)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	534	Target Neighborhood Hits	337	Shared Neighborhood Hits	139
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

STTP1_HUMAN
NC score	0.138485 (rank : 1043)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	534	Target Neighborhood Hits	232	Shared Neighborhood Hits	125
SwissProt Accessions	Q6IA86, Q53GZ0, Q687Y8, Q8N5C2, Q96GV4, Q96PI7, Q9H9N0, Q9NV81	Gene names	STATIP1
Domain Architecture	No domain graphic available
Description	Stat3-interacting protein (StIP1) (SHINC-2).

WDFY2_HUMAN
NC score	0.138468 (rank : 1044)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	137
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

EMAL4_HUMAN
NC score	0.138339 (rank : 1045)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	534	Target Neighborhood Hits	306	Shared Neighborhood Hits	123
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

FBXW5_HUMAN
NC score	0.137881 (rank : 1046)	θ value	1.38821 (rank : 367)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	98
SwissProt Accessions	Q969U6, Q5SPZ8, Q5SPZ9, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3	Gene names	FBXW5, FBW5
Domain Architecture
Description	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5).

TLE3_MOUSE
NC score	0.137793 (rank : 1047)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	534	Target Neighborhood Hits	378	Shared Neighborhood Hits	134
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

CORO7_MOUSE
NC score	0.137603 (rank : 1048)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	534	Target Neighborhood Hits	312	Shared Neighborhood Hits	145
SwissProt Accessions	Q9D2V7, Q3UDJ4, Q6P8Y8, Q8C9V7	Gene names	Coro7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

CORO7_HUMAN
NC score	0.137458 (rank : 1049)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	534	Target Neighborhood Hits	315	Shared Neighborhood Hits	144
SwissProt Accessions	P57737	Gene names	CORO7
Domain Architecture
Description	Coronin-7 (70 kDa WD repeat tumor rejection antigen homolog).

TLE3_HUMAN
NC score	0.136841 (rank : 1050)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	534	Target Neighborhood Hits	385	Shared Neighborhood Hits	134
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

K2002_HUMAN
NC score	0.136694 (rank : 1051)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	534	Target Neighborhood Hits	274	Shared Neighborhood Hits	145
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

BOP1_HUMAN
NC score	0.136589 (rank : 1052)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	534	Target Neighborhood Hits	257	Shared Neighborhood Hits	126
SwissProt Accessions	Q14137, Q969Z6, Q96IS8, Q9BSA7, Q9BVM0	Gene names	BOP1, KIAA0124
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

TLE1_HUMAN
NC score	0.136573 (rank : 1053)	θ value	6.88961 (rank : 508)
Query Neighborhood Hits	534	Target Neighborhood Hits	485	Shared Neighborhood Hits	138
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
NC score	0.136361 (rank : 1054)	θ value	6.88961 (rank : 509)
Query Neighborhood Hits	534	Target Neighborhood Hits	491	Shared Neighborhood Hits	137
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

WDR41_MOUSE
NC score	0.136082 (rank : 1055)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	114
SwissProt Accessions	Q3UDP0, Q8C4F1, Q8C8K5	Gene names	Wdr41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

DDB2_HUMAN
NC score	0.133668 (rank : 1056)	θ value	8.99809 (rank : 517)
Query Neighborhood Hits	534	Target Neighborhood Hits	175	Shared Neighborhood Hits	102
SwissProt Accessions	Q92466, Q76E54, Q76E55, Q76E56, Q76E57	Gene names	DDB2
Domain Architecture
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) (DDB p48 subunit) (DDBb) (UV-damaged DNA-binding protein 2) (UV-DDB 2).

AHI1_HUMAN
NC score	0.132899 (rank : 1057)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	534	Target Neighborhood Hits	537	Shared Neighborhood Hits	129
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

THOC6_MOUSE
NC score	0.132718 (rank : 1058)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	534	Target Neighborhood Hits	199	Shared Neighborhood Hits	113
SwissProt Accessions	Q5U4D9	Gene names	Thoc6, Wdr58
Domain Architecture	No domain graphic available
Description	THO complex subunit 6 homolog (WD repeat protein 58).

ANPRB_MOUSE
NC score	0.131995 (rank : 1059)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	534	Target Neighborhood Hits	607	Shared Neighborhood Hits	217
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

EMAL2_HUMAN
NC score	0.131780 (rank : 1060)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	534	Target Neighborhood Hits	217	Shared Neighborhood Hits	116
SwissProt Accessions	O95834, Q9UG50	Gene names	EML2, EMAP2, EMAPL2
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2).

2AAB_MOUSE
NC score	0.129980 (rank : 1061)	θ value	0.00665767 (rank : 81)
Query Neighborhood Hits	534	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNP2	Gene names	Ppp2r1b
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

ZF106_MOUSE
NC score	0.128197 (rank : 1062)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	534	Target Neighborhood Hits	472	Shared Neighborhood Hits	113
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

GUC2C_HUMAN
NC score	0.127766 (rank : 1063)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	534	Target Neighborhood Hits	624	Shared Neighborhood Hits	227
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

WDR4_HUMAN
NC score	0.126685 (rank : 1064)	θ value	4.03905 (rank : 463)
Query Neighborhood Hits	534	Target Neighborhood Hits	145	Shared Neighborhood Hits	97
SwissProt Accessions	P57081, Q9HCR3	Gene names	WDR4
Domain Architecture
Description	WD repeat protein 4.

NUP43_HUMAN
NC score	0.126332 (rank : 1065)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	534	Target Neighborhood Hits	198	Shared Neighborhood Hits	106
SwissProt Accessions	Q8NFH3, Q9H8S0	Gene names	NUP43
Domain Architecture
Description	Nucleoporin Nup43 (p42).

NUP43_MOUSE
NC score	0.126229 (rank : 1066)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	534	Target Neighborhood Hits	193	Shared Neighborhood Hits	100
SwissProt Accessions	P59235	Gene names	Nup43
Domain Architecture
Description	Nucleoporin Nup43.

EMAL1_HUMAN
NC score	0.126070 (rank : 1067)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	111
SwissProt Accessions	O00423	Gene names	EML1, EMAP1, EMAPL, EMAPL1
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1).

2AAB_HUMAN
NC score	0.125770 (rank : 1068)	θ value	0.00869519 (rank : 90)
Query Neighborhood Hits	534	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

WDR81_MOUSE
NC score	0.124320 (rank : 1069)	θ value	6.88961 (rank : 511)
Query Neighborhood Hits	534	Target Neighborhood Hits	228	Shared Neighborhood Hits	115
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

WDR20_MOUSE
NC score	0.123757 (rank : 1070)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	534	Target Neighborhood Hits	217	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D5R2	Gene names	Wdr20
Domain Architecture
Description	WD repeat protein 20.

VRK3_HUMAN
NC score	0.123751 (rank : 1071)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	534	Target Neighborhood Hits	349	Shared Neighborhood Hits	167
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

DMWD_MOUSE
NC score	0.123663 (rank : 1072)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	534	Target Neighborhood Hits	282	Shared Neighborhood Hits	119
SwissProt Accessions	Q08274	Gene names	Dmwd, Dm9
Domain Architecture
Description	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (DMR-N9 protein).

WDR20_HUMAN
NC score	0.122335 (rank : 1073)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	534	Target Neighborhood Hits	249	Shared Neighborhood Hits	116
SwissProt Accessions	Q8TBZ3, Q8WXX2, Q9UF86	Gene names	WDR20
Domain Architecture
Description	WD repeat protein 20 (DMR protein).

WDR41_HUMAN
NC score	0.121231 (rank : 1074)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	534	Target Neighborhood Hits	208	Shared Neighborhood Hits	112
SwissProt Accessions	Q9HAD4, Q7Z792, Q8IWG3, Q8IXA9, Q8NDA7, Q9NV62	Gene names	WDR41
Domain Architecture	No domain graphic available
Description	WD repeat protein 41.

NUP37_MOUSE
NC score	0.121041 (rank : 1075)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	534	Target Neighborhood Hits	159	Shared Neighborhood Hits	92
SwissProt Accessions	Q9CWU9	Gene names	Nup37
Domain Architecture
Description	Nucleoporin Nup37.

COR2A_MOUSE
NC score	0.120667 (rank : 1076)	θ value	4.03905 (rank : 445)
Query Neighborhood Hits	534	Target Neighborhood Hits	204	Shared Neighborhood Hits	117
SwissProt Accessions	Q8C0P5, Q3U6H8, Q8BW42	Gene names	Coro2a
Domain Architecture	No domain graphic available
Description	Coronin-2A.

CORO6_MOUSE
NC score	0.120541 (rank : 1077)	θ value	6.88961 (rank : 496)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	119
SwissProt Accessions	Q920M5, Q920M3, Q920M4	Gene names	Coro6
Domain Architecture	No domain graphic available
Description	Coronin-6 (Clipin E).

DDB2_MOUSE
NC score	0.119838 (rank : 1078)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	534	Target Neighborhood Hits	175	Shared Neighborhood Hits	104
SwissProt Accessions	Q99J79	Gene names	Ddb2
Domain Architecture	No domain graphic available
Description	DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2).

WDR13_HUMAN
NC score	0.119837 (rank : 1079)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	534	Target Neighborhood Hits	186	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H1Z4, Q9BUL7, Q9NWW4	Gene names	WDR13
Domain Architecture
Description	WD repeat protein 13.

ANPRA_MOUSE
NC score	0.119651 (rank : 1080)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	534	Target Neighborhood Hits	600	Shared Neighborhood Hits	202
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

COR2B_HUMAN
NC score	0.118302 (rank : 1081)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	534	Target Neighborhood Hits	233	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UQ03, O94767, Q8TAN1	Gene names	CORO2B, KIAA0925
Domain Architecture
Description	Coronin-2B (Coronin-like protein C) (ClipinC) (Protein FC96).

COR2B_MOUSE
NC score	0.117079 (rank : 1082)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	534	Target Neighborhood Hits	235	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BH44, Q6P5U9	Gene names	Coro2b
Domain Architecture	No domain graphic available
Description	Coronin-2B.

TEX14_HUMAN
NC score	0.116774 (rank : 1083)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	534	Target Neighborhood Hits	1103	Shared Neighborhood Hits	231
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

WDR13_MOUSE
NC score	0.115841 (rank : 1084)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	107
SwissProt Accessions	Q91V09	Gene names	Wdr13
Domain Architecture
Description	WD repeat protein 13.

TSCC1_MOUSE
NC score	0.115818 (rank : 1085)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	534	Target Neighborhood Hits	160	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K0G5	Gene names	Tssc1
Domain Architecture	No domain graphic available
Description	Protein TSSC1.

TSSC1_HUMAN
NC score	0.115021 (rank : 1086)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	534	Target Neighborhood Hits	157	Shared Neighborhood Hits	86
SwissProt Accessions	Q53HC9, O43179, Q53S19, Q53SG2	Gene names	TSSC1
Domain Architecture	No domain graphic available
Description	Protein TSSC1 (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) (Tumor-suppressing STF cDNA 1 protein).

WDR76_HUMAN
NC score	0.114480 (rank : 1087)	θ value	0.21417 (rank : 239)
Query Neighborhood Hits	534	Target Neighborhood Hits	73	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H967	Gene names	WDR76
Domain Architecture	No domain graphic available
Description	WD repeat protein 76.

ANPRA_HUMAN
NC score	0.114004 (rank : 1088)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	534	Target Neighborhood Hits	612	Shared Neighborhood Hits	203
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

K2002_MOUSE
NC score	0.113967 (rank : 1089)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	534	Target Neighborhood Hits	267	Shared Neighborhood Hits	132
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NUP37_HUMAN
NC score	0.113812 (rank : 1090)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	534	Target Neighborhood Hits	153	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NFH4, Q9H644	Gene names	NUP37
Domain Architecture
Description	Nucleoporin Nup37 (p37).

WD21C_HUMAN
NC score	0.113341 (rank : 1091)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	534	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NA75	Gene names	WDR21C
Domain Architecture	No domain graphic available
Description	WD repeat protein 21C.

COR1C_MOUSE
NC score	0.113177 (rank : 1092)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	534	Target Neighborhood Hits	251	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WUM4, Q8VCQ5	Gene names	Coro1c
Domain Architecture
Description	Coronin-1C (Coronin-3).

COR1C_HUMAN
NC score	0.112917 (rank : 1093)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	534	Target Neighborhood Hits	246	Shared Neighborhood Hits	130
SwissProt Accessions	Q9ULV4, Q9NSK5	Gene names	CORO1C, CRNN4
Domain Architecture
Description	Coronin-1C (Coronin-3) (hCRNN4).

STK31_MOUSE
NC score	0.112114 (rank : 1094)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	534	Target Neighborhood Hits	474	Shared Neighborhood Hits	154
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.111885 (rank : 1095)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	534	Target Neighborhood Hits	857	Shared Neighborhood Hits	226
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

IFT80_HUMAN
NC score	0.110846 (rank : 1096)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	534	Target Neighborhood Hits	195	Shared Neighborhood Hits	94
SwissProt Accessions	Q9P2H3	Gene names	IFT80, KIAA1374, WDR56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

COR2A_HUMAN
NC score	0.110844 (rank : 1097)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	534	Target Neighborhood Hits	214	Shared Neighborhood Hits	112
SwissProt Accessions	Q92828, Q92829, Q9BWS5	Gene names	CORO2A, IR10, WDR2
Domain Architecture
Description	Coronin-2A (WD repeat-containing protein 2) (IR10).

ILK_MOUSE
NC score	0.110057 (rank : 1098)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	534	Target Neighborhood Hits	858	Shared Neighborhood Hits	227
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

COR1A_MOUSE
NC score	0.109194 (rank : 1099)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	534	Target Neighborhood Hits	243	Shared Neighborhood Hits	127
SwissProt Accessions	O89053, Q7TMU0, Q9R1Y8, Q9R288	Gene names	Coro1a, Coro1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

WDR7_MOUSE
NC score	0.109131 (rank : 1100)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	534	Target Neighborhood Hits	226	Shared Neighborhood Hits	116
SwissProt Accessions	Q920I9, Q80TY3, Q920J0	Gene names	Wdr7, Kiaa0541, Trag
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG).

IFT80_MOUSE
NC score	0.109091 (rank : 1101)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	97
SwissProt Accessions	Q8K057	Gene names	Ift80, Wdr56
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 80 homolog (WD repeat protein 56).

ILK2_HUMAN
NC score	0.107224 (rank : 1102)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	534	Target Neighborhood Hits	848	Shared Neighborhood Hits	222
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

WDR81_HUMAN
NC score	0.106128 (rank : 1103)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	534	Target Neighborhood Hits	205	Shared Neighborhood Hits	98
SwissProt Accessions	Q562E7, Q24JP6, Q8N277, Q8N3F3	Gene names	WDR81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

COR1B_HUMAN
NC score	0.105973 (rank : 1104)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	534	Target Neighborhood Hits	239	Shared Neighborhood Hits	121
SwissProt Accessions	Q9BR76	Gene names	CORO1B
Domain Architecture
Description	Coronin-1B (Coronin-2).

COR1A_HUMAN
NC score	0.105780 (rank : 1105)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	534	Target Neighborhood Hits	240	Shared Neighborhood Hits	122
SwissProt Accessions	P31146	Gene names	CORO1A, CORO1
Domain Architecture
Description	Coronin-1A (Coronin-like protein p57) (Coronin-like protein A) (CLIPINA) (Tryptophan aspartate-containing coat protein) (TACO).

WDR7_HUMAN
NC score	0.105565 (rank : 1106)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	534	Target Neighborhood Hits	244	Shared Neighborhood Hits	117
SwissProt Accessions	Q9Y4E6, Q86UX5, Q86VP2, Q96PS7	Gene names	WDR7, KIAA0541, TRAG
Domain Architecture	No domain graphic available
Description	WD repeat protein 7 (TGF-beta resistance-associated protein TRAG) (Rabconnectin-3 beta).

DMXL2_HUMAN
NC score	0.105332 (rank : 1107)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	534	Target Neighborhood Hits	374	Shared Neighborhood Hits	123
SwissProt Accessions	Q8TDJ6, O94938	Gene names	DMXL2, KIAA0856
Domain Architecture	No domain graphic available
Description	Protein DmX-like 2 (Rabconnectin-3).

VRK3_MOUSE
NC score	0.104969 (rank : 1108)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	534	Target Neighborhood Hits	342	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

COR1B_MOUSE
NC score	0.104613 (rank : 1109)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	534	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q9WUM3, Q3UEB1, Q9CVA2	Gene names	Coro1b
Domain Architecture
Description	Coronin-1B (Coronin-2).

WDR4_MOUSE
NC score	0.100656 (rank : 1110)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	85
SwissProt Accessions	Q9EP82	Gene names	Wdr4
Domain Architecture
Description	WD repeat protein 4.

AAAS_HUMAN
NC score	0.098533 (rank : 1111)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	534	Target Neighborhood Hits	154	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NRG9, Q9NWI6, Q9UG19	Gene names	AAAS, ADRACALA
Domain Architecture
Description	Aladin (Adracalin).

CIR1A_HUMAN
NC score	0.096072 (rank : 1112)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	534	Target Neighborhood Hits	158	Shared Neighborhood Hits	88
SwissProt Accessions	Q969X6, Q8NCD9, Q8TF14, Q96SP0, Q96SR9, Q96SZ9, Q96T13, Q9BWK6	Gene names	CIRH1A, KIAA1988
Domain Architecture
Description	Cirhin.

DMXL1_MOUSE
NC score	0.095798 (rank : 1113)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	534	Target Neighborhood Hits	257	Shared Neighborhood Hits	114
SwissProt Accessions	Q6PNC0, Q3TLG8, Q6PHM6, Q8BQF2	Gene names	Dmxl1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

PREB_HUMAN
NC score	0.093077 (rank : 1114)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	534	Target Neighborhood Hits	163	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HCU5, Q9UH94	Gene names	PREB, SEC12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

WD21A_HUMAN
NC score	0.092455 (rank : 1115)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WV16, Q86U31, Q96K22, Q9Y4P5	Gene names	WDR21A, WDR21
Domain Architecture
Description	WD repeat protein 21A.

PXK_MOUSE
NC score	0.091169 (rank : 1116)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	534	Target Neighborhood Hits	320	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

WDR46_HUMAN
NC score	0.090605 (rank : 1117)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	534	Target Neighborhood Hits	147	Shared Neighborhood Hits	72
SwissProt Accessions	O15213, Q5STK5	Gene names	WDR46, BING4, C6orf11
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

UTP18_HUMAN
NC score	0.090377 (rank : 1118)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y5J1, Q9H4N6	Gene names	UTP18, WDR50
Domain Architecture
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

TLE6_MOUSE
NC score	0.090299 (rank : 1119)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	534	Target Neighborhood Hits	178	Shared Neighborhood Hits	87
SwissProt Accessions	Q9WVB3	Gene names	Tle6, Grg6
Domain Architecture
Description	Transducin-like enhancer protein 6 (Groucho-related protein 6).

PPWD1_MOUSE
NC score	0.089082 (rank : 1120)	θ value	0.21417 (rank : 234)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	70
SwissProt Accessions	Q8CEC6	Gene names	Ppwd1
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

CIR1A_MOUSE
NC score	0.089076 (rank : 1121)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	534	Target Neighborhood Hits	155	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R2N2, Q62306, Q69Z48, Q6NVG9, Q8VEL5	Gene names	Cirh1a, Kiaa1988, Tex292
Domain Architecture	No domain graphic available
Description	Cirhin (Testis-expressed gene 292 protein).

PREB_MOUSE
NC score	0.087358 (rank : 1122)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUQ2, Q9QZ99	Gene names	Preb, Sec12
Domain Architecture
Description	Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12).

PPWD1_HUMAN
NC score	0.086826 (rank : 1123)	θ value	0.365318 (rank : 272)
Query Neighborhood Hits	534	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q96BP3, Q15002, Q7KZ89	Gene names	PPWD1, KIAA0073
Domain Architecture	No domain graphic available
Description	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8).

AAAS_MOUSE
NC score	0.084164 (rank : 1124)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	534	Target Neighborhood Hits	144	Shared Neighborhood Hits	83
SwissProt Accessions	P58742, Q544M6	Gene names	Aaas
Domain Architecture
Description	Aladin (Adracalin).

DMXL1_HUMAN
NC score	0.082817 (rank : 1125)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	534	Target Neighborhood Hits	259	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y485	Gene names	DMXL1, XL1
Domain Architecture	No domain graphic available
Description	Protein DmX-like 1 (X-like 1 protein).

DNAI1_HUMAN
NC score	0.082740 (rank : 1126)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	534	Target Neighborhood Hits	148	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UI46, Q9UEZ8	Gene names	DNAI1
Domain Architecture
Description	Dynein intermediate chain 1, axonemal (Axonemal dynein intermediate chain 1).

WDR72_HUMAN
NC score	0.082675 (rank : 1127)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	534	Target Neighborhood Hits	167	Shared Neighborhood Hits	86
SwissProt Accessions	Q3MJ13, Q7Z3I3, Q8N8X2	Gene names	WDR72
Domain Architecture	No domain graphic available
Description	WD repeat protein 72.

WDR46_MOUSE
NC score	0.082028 (rank : 1128)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	534	Target Neighborhood Hits	243	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0H1	Gene names	Wdr46, Bing4
Domain Architecture
Description	WD repeat protein 46 (WD repeat protein BING4).

PP4R1_MOUSE
NC score	0.081974 (rank : 1129)	θ value	0.279714 (rank : 251)
Query Neighborhood Hits	534	Target Neighborhood Hits	94	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K2V1, Q8R0R8	Gene names	Ppp4r1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

LYST_HUMAN
NC score	0.079752 (rank : 1130)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	534	Target Neighborhood Hits	324	Shared Neighborhood Hits	99
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

PP4R1_HUMAN
NC score	0.079740 (rank : 1131)	θ value	0.365318 (rank : 271)
Query Neighborhood Hits	534	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TF05, Q99774, Q9UNQ7	Gene names	PPP4R1, MEG1, PP4R1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

KI21B_HUMAN
NC score	0.079360 (rank : 1132)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	534	Target Neighborhood Hits	1017	Shared Neighborhood Hits	155
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

FBXW8_HUMAN
NC score	0.078712 (rank : 1133)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	534	Target Neighborhood Hits	192	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

WDR68_HUMAN
NC score	0.077892 (rank : 1134)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	P61962, O15491, Q9DAE4	Gene names	WDR68, HAN11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDR68_MOUSE
NC score	0.077892 (rank : 1135)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	P61963, O15491, Q3TMV9, Q9DAE4	Gene names	Wdr68, Han11
Domain Architecture
Description	WD repeat protein 68 (WD repeat protein An11 homolog).

WDFY3_MOUSE
NC score	0.077866 (rank : 1136)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	534	Target Neighborhood Hits	332	Shared Neighborhood Hits	109
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.077223 (rank : 1137)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	534	Target Neighborhood Hits	348	Shared Neighborhood Hits	110
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

UTP18_MOUSE
NC score	0.076952 (rank : 1138)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	67
SwissProt Accessions	Q5SSI6	Gene names	Utp18, Wdr50
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 18 homolog (WD repeat protein 50).

KI21B_MOUSE
NC score	0.076696 (rank : 1139)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	534	Target Neighborhood Hits	997	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

WDR85_HUMAN
NC score	0.076541 (rank : 1140)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	534	Target Neighborhood Hits	134	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BTV6, Q96AB7	Gene names	WDR85, C9orf112
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

PRPK_HUMAN
NC score	0.075958 (rank : 1141)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	534	Target Neighborhood Hits	131	Shared Neighborhood Hits	75
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

KI21A_MOUSE
NC score	0.075550 (rank : 1142)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	534	Target Neighborhood Hits	1317	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

WDR67_MOUSE
NC score	0.074713 (rank : 1143)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	534	Target Neighborhood Hits	476	Shared Neighborhood Hits	91
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

KI21A_HUMAN
NC score	0.074660 (rank : 1144)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	534	Target Neighborhood Hits	1543	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

LYST_MOUSE
NC score	0.074577 (rank : 1145)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	534	Target Neighborhood Hits	286	Shared Neighborhood Hits	98
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

NBEAL_HUMAN
NC score	0.072153 (rank : 1146)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	534	Target Neighborhood Hits	200	Shared Neighborhood Hits	92
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

PXK_HUMAN
NC score	0.071382 (rank : 1147)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	534	Target Neighborhood Hits	216	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PRPK_MOUSE
NC score	0.071379 (rank : 1148)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	73
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

DNAI2_HUMAN
NC score	0.069637 (rank : 1149)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	534	Target Neighborhood Hits	156	Shared Neighborhood Hits	73
SwissProt Accessions	Q9GZS0, Q9H179, Q9NT53	Gene names	DNAI2
Domain Architecture
Description	Dynein intermediate chain 2, axonemal (Axonemal dynein intermediate chain 2).

ARC1B_HUMAN
NC score	0.069563 (rank : 1150)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	534	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	O15143, Q9BU00	Gene names	ARPC1B, ARC41
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

STB5L_HUMAN
NC score	0.069059 (rank : 1151)	θ value	0.47712 (rank : 301)
Query Neighborhood Hits	534	Target Neighborhood Hits	139	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2K9, Q4G1B4, Q6PIC3	Gene names	STXBP5L, KIAA1006, LLGL4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

STB5L_MOUSE
NC score	0.069046 (rank : 1152)	θ value	0.47712 (rank : 302)
Query Neighborhood Hits	534	Target Neighborhood Hits	138	Shared Neighborhood Hits	66
SwissProt Accessions	Q5DQR4, Q3TSM3, Q3UVG2, Q5DQR1, Q5DQR2, Q5DQR3, Q8BS52	Gene names	Stxbp5l, Llgl4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 5-like (Tomosyn-2) (Lethal(2) giant larvae protein homolog 4).

DC1I2_MOUSE
NC score	0.067168 (rank : 1153)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	534	Target Neighborhood Hits	209	Shared Neighborhood Hits	83
SwissProt Accessions	O88487, Q3TGH7	Gene names	Dync1i2, Dnci2, Dncic2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DC1I2_HUMAN
NC score	0.066286 (rank : 1154)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	534	Target Neighborhood Hits	201	Shared Neighborhood Hits	83
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

WDR67_HUMAN
NC score	0.066241 (rank : 1155)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	534	Target Neighborhood Hits	782	Shared Neighborhood Hits	110
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

FBXW8_MOUSE
NC score	0.065913 (rank : 1156)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	534	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

RN5A_HUMAN
NC score	0.064743 (rank : 1157)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	534	Target Neighborhood Hits	608	Shared Neighborhood Hits	167
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ARC1B_MOUSE
NC score	0.064512 (rank : 1158)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	534	Target Neighborhood Hits	133	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV32	Gene names	Arpc1b
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1B (ARP2/3 complex 41 kDa subunit) (p41-ARC).

TLE6_HUMAN
NC score	0.064022 (rank : 1159)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	534	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H808	Gene names	TLE6
Domain Architecture	No domain graphic available
Description	Transducin-like enhancer protein 6.

TF3C2_MOUSE
NC score	0.063875 (rank : 1160)	θ value	4.03905 (rank : 460)
Query Neighborhood Hits	534	Target Neighborhood Hits	165	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

RPTOR_HUMAN
NC score	0.063408 (rank : 1161)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	534	Target Neighborhood Hits	121	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N122, Q8N4V9, Q8TB32, Q9P2P3	Gene names	RAPTOR, KIAA1303
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

WDR74_HUMAN
NC score	0.061429 (rank : 1162)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	534	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q6RFH5, Q9BRC9, Q9H6X8, Q9NVY2	Gene names	WDR74, NSA1
Domain Architecture	No domain graphic available
Description	WD repeat protein 74 (NOP seven-associated protein 1).

WDR34_MOUSE
NC score	0.060782 (rank : 1163)	θ value	5.27518 (rank : 489)
Query Neighborhood Hits	534	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	Q5U4F6	Gene names	Wdr34
Domain Architecture	No domain graphic available
Description	WD repeat protein 34.

RPTOR_MOUSE
NC score	0.058138 (rank : 1164)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	534	Target Neighborhood Hits	129	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K4Q0, Q8C9W9, Q8CBY4, Q8CDY8, Q9D4H3	Gene names	Raptor
Domain Architecture
Description	Regulatory-associated protein of mTOR (Raptor) (P150 target of rapamycin (TOR)-scaffold protein).

TF3C2_HUMAN
NC score	0.054991 (rank : 1165)	θ value	5.27518 (rank : 487)
Query Neighborhood Hits	534	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

ARC1A_HUMAN
NC score	0.054592 (rank : 1166)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	534	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q92747, Q7Z5U8, Q86WU5, Q8IXQ0	Gene names	ARPC1A, SOP2L
Domain Architecture
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein).

ARC1A_MOUSE
NC score	0.053758 (rank : 1167)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	534	Target Neighborhood Hits	120	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R0Q6, Q3UL75	Gene names	Arpc1a, Sid329
Domain Architecture	No domain graphic available
Description	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) (Sid 329).

WDR85_MOUSE
NC score	0.052952 (rank : 1168)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	534	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q9CYU6, Q5RJV7, Q8BIT9	Gene names	Wdr85
Domain Architecture	No domain graphic available
Description	WD repeat protein 85.

VPS11_MOUSE
NC score	0.041157 (rank : 1169)	θ value	1.38821 (rank : 389)
Query Neighborhood Hits	534	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

VPS11_HUMAN
NC score	0.040853 (rank : 1170)	θ value	1.38821 (rank : 388)
Query Neighborhood Hits	534	Target Neighborhood Hits	86	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

SYMPK_HUMAN
NC score	0.038596 (rank : 1171)	θ value	1.06291 (rank : 357)
Query Neighborhood Hits	534	Target Neighborhood Hits	90	Shared Neighborhood Hits	10
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

SYMPK_MOUSE
NC score	0.037693 (rank : 1172)	θ value	1.38821 (rank : 379)
Query Neighborhood Hits	534	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

SYG_MOUSE
NC score	0.036154 (rank : 1173)	θ value	0.279714 (rank : 255)
Query Neighborhood Hits	534	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZD3, Q8VC67	Gene names	Gars
Domain Architecture
Description	Glycyl-tRNA synthetase (EC 6.1.1.14) (Glycine--tRNA ligase) (GlyRS).

SF3B1_HUMAN
NC score	0.031036 (rank : 1174)	θ value	5.27518 (rank : 479)
Query Neighborhood Hits	534	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

RHPN1_HUMAN
NC score	0.029327 (rank : 1175)	θ value	1.38821 (rank : 374)
Query Neighborhood Hits	534	Target Neighborhood Hits	158	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

HEAT1_HUMAN
NC score	0.027064 (rank : 1176)	θ value	3.0926 (rank : 429)
Query Neighborhood Hits	534	Target Neighborhood Hits	52	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H583, Q5T3Q8, Q9NW23	Gene names	HEATR1, BAP28
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 1 (Protein BAP28).

PUSL1_HUMAN
NC score	0.026848 (rank : 1177)	θ value	3.0926 (rank : 434)
Query Neighborhood Hits	534	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0Z8	Gene names	PUSL1
Domain Architecture	No domain graphic available
Description	tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA-uridine isomerase-like 1) (tRNA pseudouridylate synthase-like 1).

RT31_HUMAN
NC score	0.026684 (rank : 1178)	θ value	4.03905 (rank : 457)
Query Neighborhood Hits	534	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q92665, Q5VYC8, Q8WTV8	Gene names	MRPS31, IMOGN38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

NOL10_MOUSE
NC score	0.023745 (rank : 1179)	θ value	6.88961 (rank : 503)
Query Neighborhood Hits	534	Target Neighborhood Hits	206	Shared Neighborhood Hits	33
SwissProt Accessions	Q5RJG1	Gene names	Nol10, Gm67
Domain Architecture	No domain graphic available
Description	Nucleolar protein 10.

UBXD3_MOUSE
NC score	0.020992 (rank : 1180)	θ value	4.03905 (rank : 461)
Query Neighborhood Hits	534	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

SOX12_MOUSE
NC score	0.020392 (rank : 1181)	θ value	0.62314 (rank : 322)
Query Neighborhood Hits	534	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

T22D2_HUMAN
NC score	0.017506 (rank : 1182)	θ value	5.27518 (rank : 485)
Query Neighborhood Hits	534	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TAB3_MOUSE
NC score	0.017155 (rank : 1183)	θ value	2.36792 (rank : 417)
Query Neighborhood Hits	534	Target Neighborhood Hits	273	Shared Neighborhood Hits	15
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

RN169_HUMAN
NC score	0.016859 (rank : 1184)	θ value	8.99809 (rank : 532)
Query Neighborhood Hits	534	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

PER3_HUMAN
NC score	0.014690 (rank : 1185)	θ value	5.27518 (rank : 478)
Query Neighborhood Hits	534	Target Neighborhood Hits	479	Shared Neighborhood Hits	19
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

KCTD3_HUMAN
NC score	0.014621 (rank : 1186)	θ value	8.99809 (rank : 521)
Query Neighborhood Hits	534	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y597, Q49AG7, Q504Q9, Q6PJN6, Q8ND58, Q8NDJ0, Q8WX16	Gene names	KCTD3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3 (NY-REN-45 antigen).

PCQAP_HUMAN
NC score	0.014568 (rank : 1187)	θ value	4.03905 (rank : 453)
Query Neighborhood Hits	534	Target Neighborhood Hits	549	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

KCTD3_MOUSE
NC score	0.014486 (rank : 1188)	θ value	8.99809 (rank : 522)
Query Neighborhood Hits	534	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFX3, Q6P7X4	Gene names	Kctd3
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD3.

FOXP1_MOUSE
NC score	0.014432 (rank : 1189)	θ value	1.38821 (rank : 368)
Query Neighborhood Hits	534	Target Neighborhood Hits	241	Shared Neighborhood Hits	9
SwissProt Accessions	P58462	Gene names	Foxp1
Domain Architecture
Description	Forkhead box protein P1 (Forkhead-related transcription factor 1).

PTN23_HUMAN
NC score	0.013062 (rank : 1190)	θ value	1.06291 (rank : 356)
Query Neighborhood Hits	534	Target Neighborhood Hits	646	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

FOXP2_MOUSE
NC score	0.012525 (rank : 1191)	θ value	3.0926 (rank : 427)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	14
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

FOXP1_HUMAN
NC score	0.012313 (rank : 1192)	θ value	4.03905 (rank : 449)
Query Neighborhood Hits	534	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H334, Q9H332, Q9H333, Q9P0R1	Gene names	FOXP1
Domain Architecture
Description	Forkhead box protein P1.

FOXP2_HUMAN
NC score	0.010681 (rank : 1193)	θ value	6.88961 (rank : 498)
Query Neighborhood Hits	534	Target Neighborhood Hits	366	Shared Neighborhood Hits	14
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

G3ST3_MOUSE
NC score	0.010121 (rank : 1194)	θ value	5.27518 (rank : 468)
Query Neighborhood Hits	534	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P61315	Gene names	Gal3st3
Domain Architecture	No domain graphic available
Description	Galactose-3-O-sulfotransferase 3 (EC 2.8.2.-) (Galbeta1-3GalNAc 3'- sulfotransferase) (Beta-galactose-3-O-sulfotransferase 3).

ZAN_HUMAN
NC score	0.009814 (rank : 1195)	θ value	1.81305 (rank : 403)
Query Neighborhood Hits	534	Target Neighborhood Hits	679	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

IP6K2_MOUSE
NC score	0.009504 (rank : 1196)	θ value	5.27518 (rank : 471)
Query Neighborhood Hits	534	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q80V72	Gene names	Ihpk2, Ip6k2
Domain Architecture	No domain graphic available
Description	Inositol hexakisphosphate kinase 2 (EC 2.7.4.21) (InsP6 kinase 2) (Inositol hexakisphosphate kinase 2) (P(i)-uptake stimulator) (PiUS).

NUBP1_HUMAN
NC score	0.008758 (rank : 1197)	θ value	6.88961 (rank : 504)
Query Neighborhood Hits	534	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P53384	Gene names	NUBP1, NBP, NBP1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

GOGA3_HUMAN
NC score	0.007848 (rank : 1198)	θ value	3.0926 (rank : 428)
Query Neighborhood Hits	534	Target Neighborhood Hits	1317	Shared Neighborhood Hits	43
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

SYCP1_HUMAN
NC score	0.005274 (rank : 1199)	θ value	5.27518 (rank : 484)
Query Neighborhood Hits	534	Target Neighborhood Hits	1313	Shared Neighborhood Hits	36
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

EP400_HUMAN
NC score	0.004511 (rank : 1200)	θ value	4.03905 (rank : 446)
Query Neighborhood Hits	534	Target Neighborhood Hits	556	Shared Neighborhood Hits	15
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

CN145_HUMAN
NC score	0.004239 (rank : 1201)	θ value	6.88961 (rank : 495)
Query Neighborhood Hits	534	Target Neighborhood Hits	1196	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

ANR18_HUMAN
NC score	0.002788 (rank : 1202)	θ value	1.81305 (rank : 391)
Query Neighborhood Hits	534	Target Neighborhood Hits	1106	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

BPA1_MOUSE
NC score	0.000725 (rank : 1203)	θ value	8.99809 (rank : 512)
Query Neighborhood Hits	534	Target Neighborhood Hits	1477	Shared Neighborhood Hits	42
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).