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Network neighborhood for query Sequence : SMAD4_HUMAN

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SMAD4_HUMAN
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SMAD4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SMAD4_MOUSE
θ value	0 (rank : 2)	NC score	0.985217 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

SMAD3_HUMAN
θ value	1.90147e-66 (rank : 3)	NC score	0.929801 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	P84022, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4	Gene names	SMAD3, MADH3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3).

SMAD3_MOUSE
θ value	1.90147e-66 (rank : 4)	NC score	0.929801 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUN5, O09064, O09144, O14510, O35273, Q8BX84, Q92940, Q93002, Q9GKR4	Gene names	Smad3, Madh3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (mMad3).

SMAD9_HUMAN
θ value	2.4834e-66 (rank : 5)	NC score	0.926339 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

SMAD5_HUMAN
θ value	7.2256e-66 (rank : 6)	NC score	0.925775 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

SMAD5_MOUSE
θ value	7.2256e-66 (rank : 7)	NC score	0.924655 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SMAD1_HUMAN
θ value	2.74572e-65 (rank : 8)	NC score	0.923974 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SMAD1_MOUSE
θ value	3.96481e-64 (rank : 9)	NC score	0.923628 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	P70340, P70442, Q9CYK6	Gene names	Smad1, Madh1, Madr1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Mothers-against-DPP-related 1) (mMad1) (Dwarfin-A) (Dwf-A).

SMAD2_HUMAN
θ value	1.2411e-41 (rank : 10)	NC score	0.909903 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q15796	Gene names	SMAD2, MADH2, MADR2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2).

SMAD2_MOUSE
θ value	1.2411e-41 (rank : 11)	NC score	0.909937 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q62432, Q9D8P6	Gene names	Smad2, Madh2, Madr2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2).

SMAD9_MOUSE
θ value	4.88048e-38 (rank : 12)	NC score	0.915432 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMAD6_HUMAN
θ value	1.2077e-20 (rank : 13)	NC score	0.782268 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

SMAD6_MOUSE
θ value	2.06002e-20 (rank : 14)	NC score	0.783315 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	O35182, Q9CW62	Gene names	Smad6, Madh6, Madh7, Msmad6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (Mad homolog 7).

SMAD7_HUMAN
θ value	2.7842e-17 (rank : 15)	NC score	0.766683 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O15105, O14740, Q6DK23	Gene names	SMAD7, MADH7, MADH8
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (hSMAD7).

SMAD7_MOUSE
θ value	2.7842e-17 (rank : 16)	NC score	0.767538 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	O35253, O88709	Gene names	Smad7, Madh7
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (Madh8).

CSPG3_HUMAN
θ value	0.0736092 (rank : 17)	NC score	0.017940 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

RNF12_HUMAN
θ value	0.163984 (rank : 18)	NC score	0.026246 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

GAK3_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.054697 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ARAF_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.001982 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ATX2L_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.043591 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

ATX2L_MOUSE
θ value	0.47712 (rank : 22)	NC score	0.042371 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	401	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

GAK12_HUMAN
θ value	0.47712 (rank : 23)	NC score	0.053445 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	374	Shared Neighborhood Hits	16
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.052928 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	429	Shared Neighborhood Hits	17
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.052617 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IF4G1_HUMAN
θ value	0.62314 (rank : 26)	NC score	0.027336 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	9
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

GAK4_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.052310 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PODXL_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.043561 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

GAK6_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.052121 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	392	Shared Neighborhood Hits	17
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MAST4_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.001939 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	1804	Shared Neighborhood Hits	19
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ADRM1_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.044041 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q16186, Q9H1P2	Gene names	ADRM1, GP110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110).

BORG5_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.047740 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q00587, Q96GN1	Gene names	CDC42EP1, BORG5, CEP1, MSE55
Domain Architecture
Description	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55).

FOXJ3_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.023922 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

GAK2_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.051638 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GLP_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.053890 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P14220	Gene names	Gypa
Domain Architecture
Description	Glycophorin.

LRC41_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.030988 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

MAP4_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.024284 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	428	Shared Neighborhood Hits	11
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

WNK1_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.002698 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	1158	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

GAK10_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.051942 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK8_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.052188 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ADRM1_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.033034 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

MILK2_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.010112 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NCOA5_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.029267 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

SRCA_MOUSE
θ value	2.36792 (rank : 44)	NC score	0.011441 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

LATS1_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.001166 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	1027	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

NCOA5_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.027024 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

UB7I3_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.012827 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

FOXN4_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.007434 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

GAK1_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.051089 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PA24B_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.009865 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PLCB3_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.006529 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

PORIM_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.074349 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N131, Q8IWS2, Q96QV2	Gene names	TMEM123, KCT3
Domain Architecture	No domain graphic available
Description	Porimin precursor (Transmembrane protein 123) (Pro-oncosis receptor inducing membrane injury) (Keratinocytes-associated transmembrane protein 3) (KCT-3).

X3CL1_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.014223 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	O35188, O35933	Gene names	Cx3cl1, Cx3c, Fkn, Scyd1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

DLG2_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.004859 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

NF2L2_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.009576 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

RERE_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.017485 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	785	Shared Neighborhood Hits	23
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

CCD22_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.007155 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	268	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

DACH1_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.012692 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

DACH1_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.012896 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYB2, O88716, Q8BPQ0, Q8C8D7, Q9QY47, Q9R218, Q9Z0Y5	Gene names	Dach1, Dach
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

MAP4_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.029284 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	17
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

ZF106_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.004625 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

ZMYM3_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.007310 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

BPTF_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.008490 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	786	Shared Neighborhood Hits	17
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CJ047_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.015585 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C5R2, Q8R017, Q8R2Z9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf47 homolog.

CNTN3_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.000074 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	455	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

NCA11_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.001782 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	661	Shared Neighborhood Hits	11
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NFAC1_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.006243 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NPAS1_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.003852 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

RCOR3_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.010729 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

SF3B1_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.011631 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.011605 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	352	Shared Neighborhood Hits	10
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SYNJ1_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.006579 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	516	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CRSP2_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.060284 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	380	Shared Neighborhood Hits	11
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

Hits sorted by NC score

SMAD4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SMAD4_MOUSE
NC score	0.985217 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

SMAD3_HUMAN
NC score	0.929801 (rank : 3)	θ value	1.90147e-66 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	P84022, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4	Gene names	SMAD3, MADH3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3).

SMAD3_MOUSE
NC score	0.929801 (rank : 4)	θ value	1.90147e-66 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BUN5, O09064, O09144, O14510, O35273, Q8BX84, Q92940, Q93002, Q9GKR4	Gene names	Smad3, Madh3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (mMad3).

SMAD9_HUMAN
NC score	0.926339 (rank : 5)	θ value	2.4834e-66 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

SMAD5_HUMAN
NC score	0.925775 (rank : 6)	θ value	7.2256e-66 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

SMAD5_MOUSE
NC score	0.924655 (rank : 7)	θ value	7.2256e-66 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SMAD1_HUMAN
NC score	0.923974 (rank : 8)	θ value	2.74572e-65 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	59	Shared Neighborhood Hits	16
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SMAD1_MOUSE
NC score	0.923628 (rank : 9)	θ value	3.96481e-64 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	P70340, P70442, Q9CYK6	Gene names	Smad1, Madh1, Madr1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Mothers-against-DPP-related 1) (mMad1) (Dwarfin-A) (Dwf-A).

SMAD9_MOUSE
NC score	0.915432 (rank : 10)	θ value	4.88048e-38 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMAD2_MOUSE
NC score	0.909937 (rank : 11)	θ value	1.2411e-41 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q62432, Q9D8P6	Gene names	Smad2, Madh2, Madr2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2).

SMAD2_HUMAN
NC score	0.909903 (rank : 12)	θ value	1.2411e-41 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q15796	Gene names	SMAD2, MADH2, MADR2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2).

SMAD6_MOUSE
NC score	0.783315 (rank : 13)	θ value	2.06002e-20 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	O35182, Q9CW62	Gene names	Smad6, Madh6, Madh7, Msmad6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (Mad homolog 7).

SMAD6_HUMAN
NC score	0.782268 (rank : 14)	θ value	1.2077e-20 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

SMAD7_MOUSE
NC score	0.767538 (rank : 15)	θ value	2.7842e-17 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	O35253, O88709	Gene names	Smad7, Madh7
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (Madh8).

SMAD7_HUMAN
NC score	0.766683 (rank : 16)	θ value	2.7842e-17 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O15105, O14740, Q6DK23	Gene names	SMAD7, MADH7, MADH8
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (hSMAD7).

PORIM_HUMAN
NC score	0.074349 (rank : 17)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N131, Q8IWS2, Q96QV2	Gene names	TMEM123, KCT3
Domain Architecture	No domain graphic available
Description	Porimin precursor (Transmembrane protein 123) (Pro-oncosis receptor inducing membrane injury) (Keratinocytes-associated transmembrane protein 3) (KCT-3).

CRSP2_HUMAN
NC score	0.060284 (rank : 18)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	380	Shared Neighborhood Hits	11
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

GAK3_HUMAN
NC score	0.054697 (rank : 19)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GLP_MOUSE
NC score	0.053890 (rank : 20)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	P14220	Gene names	Gypa
Domain Architecture
Description	Glycophorin.

GAK12_HUMAN
NC score	0.053445 (rank : 21)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	374	Shared Neighborhood Hits	16
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
NC score	0.052928 (rank : 22)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	429	Shared Neighborhood Hits	17
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.052617 (rank : 23)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
NC score	0.052310 (rank : 24)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	415	Shared Neighborhood Hits	16
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK8_HUMAN
NC score	0.052188 (rank : 25)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	145	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK6_HUMAN
NC score	0.052121 (rank : 26)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	392	Shared Neighborhood Hits	17
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK10_HUMAN
NC score	0.051942 (rank : 27)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
NC score	0.051638 (rank : 28)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK1_HUMAN
NC score	0.051089 (rank : 29)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

BORG5_HUMAN
NC score	0.047740 (rank : 30)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q00587, Q96GN1	Gene names	CDC42EP1, BORG5, CEP1, MSE55
Domain Architecture
Description	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55).

ADRM1_HUMAN
NC score	0.044041 (rank : 31)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q16186, Q9H1P2	Gene names	ADRM1, GP110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110).

ATX2L_HUMAN
NC score	0.043591 (rank : 32)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

PODXL_MOUSE
NC score	0.043561 (rank : 33)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q9R0M4, Q9ESZ1	Gene names	Podxl, Pclp1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

ATX2L_MOUSE
NC score	0.042371 (rank : 34)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	401	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

ADRM1_MOUSE
NC score	0.033034 (rank : 35)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

LRC41_HUMAN
NC score	0.030988 (rank : 36)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

MAP4_MOUSE
NC score	0.029284 (rank : 37)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	17
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NCOA5_HUMAN
NC score	0.029267 (rank : 38)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

IF4G1_HUMAN
NC score	0.027336 (rank : 39)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	9
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

NCOA5_MOUSE
NC score	0.027024 (rank : 40)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

RNF12_HUMAN
NC score	0.026246 (rank : 41)	θ value	0.163984 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

MAP4_HUMAN
NC score	0.024284 (rank : 42)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	428	Shared Neighborhood Hits	11
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

FOXJ3_HUMAN
NC score	0.023922 (rank : 43)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

CSPG3_HUMAN
NC score	0.017940 (rank : 44)	θ value	0.0736092 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

RERE_MOUSE
NC score	0.017485 (rank : 45)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	785	Shared Neighborhood Hits	23
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

CJ047_MOUSE
NC score	0.015585 (rank : 46)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C5R2, Q8R017, Q8R2Z9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf47 homolog.

X3CL1_MOUSE
NC score	0.014223 (rank : 47)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	O35188, O35933	Gene names	Cx3cl1, Cx3c, Fkn, Scyd1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

DACH1_MOUSE
NC score	0.012896 (rank : 48)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYB2, O88716, Q8BPQ0, Q8C8D7, Q9QY47, Q9R218, Q9Z0Y5	Gene names	Dach1, Dach
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

UB7I3_MOUSE
NC score	0.012827 (rank : 49)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

DACH1_HUMAN
NC score	0.012692 (rank : 50)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

SF3B1_HUMAN
NC score	0.011631 (rank : 51)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	341	Shared Neighborhood Hits	10
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
NC score	0.011605 (rank : 52)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	352	Shared Neighborhood Hits	10
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SRCA_MOUSE
NC score	0.011441 (rank : 53)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

RCOR3_HUMAN
NC score	0.010729 (rank : 54)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

MILK2_HUMAN
NC score	0.010112 (rank : 55)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

PA24B_HUMAN
NC score	0.009865 (rank : 56)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

NF2L2_HUMAN
NC score	0.009576 (rank : 57)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

BPTF_HUMAN
NC score	0.008490 (rank : 58)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	786	Shared Neighborhood Hits	17
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

FOXN4_MOUSE
NC score	0.007434 (rank : 59)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

ZMYM3_HUMAN
NC score	0.007310 (rank : 60)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	223	Shared Neighborhood Hits	4
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

CCD22_MOUSE
NC score	0.007155 (rank : 61)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	268	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

SYNJ1_MOUSE
NC score	0.006579 (rank : 62)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	516	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

PLCB3_MOUSE
NC score	0.006529 (rank : 63)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

NFAC1_HUMAN
NC score	0.006243 (rank : 64)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	312	Shared Neighborhood Hits	8
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

DLG2_HUMAN
NC score	0.004859 (rank : 65)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

ZF106_MOUSE
NC score	0.004625 (rank : 66)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

NPAS1_HUMAN
NC score	0.003852 (rank : 67)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

WNK1_HUMAN
NC score	0.002698 (rank : 68)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	1158	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ARAF_MOUSE
NC score	0.001982 (rank : 69)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

MAST4_HUMAN
NC score	0.001939 (rank : 70)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	1804	Shared Neighborhood Hits	19
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NCA11_MOUSE
NC score	0.001782 (rank : 71)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	661	Shared Neighborhood Hits	11
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

LATS1_MOUSE
NC score	0.001166 (rank : 72)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	1027	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

CNTN3_HUMAN
NC score	0.000074 (rank : 73)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	455	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).