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Network neighborhood for query Sequence : HTRA3_MOUSE

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HTRA3_MOUSE
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HTRA3_HUMAN
θ value	0 (rank : 1)	NC score	0.993220 (rank : 2)
Query Neighborhood Hits	156	Target Neighborhood Hits	152	Shared Neighborhood Hits	128
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	156	Target Neighborhood Hits	156	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA1_HUMAN
θ value	2.87295e-139 (rank : 3)	NC score	0.955822 (rank : 5)
Query Neighborhood Hits	156	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	1.63136e-134 (rank : 4)	NC score	0.960934 (rank : 3)
Query Neighborhood Hits	156	Target Neighborhood Hits	140	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA4_HUMAN
θ value	9.30652e-114 (rank : 5)	NC score	0.956735 (rank : 4)
Query Neighborhood Hits	156	Target Neighborhood Hits	119	Shared Neighborhood Hits	74
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA2_HUMAN
θ value	5.86991e-92 (rank : 6)	NC score	0.902841 (rank : 7)
Query Neighborhood Hits	156	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
θ value	5.86991e-92 (rank : 7)	NC score	0.904267 (rank : 6)
Query Neighborhood Hits	156	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_MOUSE
θ value	5.8054e-15 (rank : 8)	NC score	0.481812 (rank : 8)
Query Neighborhood Hits	156	Target Neighborhood Hits	230	Shared Neighborhood Hits	37
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IBP7_HUMAN
θ value	1.68911e-14 (rank : 9)	NC score	0.481350 (rank : 9)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	37
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

KAZD1_MOUSE
θ value	1.2105e-12 (rank : 10)	NC score	0.400929 (rank : 11)
Query Neighborhood Hits	156	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KAZD1_HUMAN
θ value	3.52202e-12 (rank : 11)	NC score	0.422747 (rank : 10)
Query Neighborhood Hits	156	Target Neighborhood Hits	248	Shared Neighborhood Hits	46
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

CRIM1_HUMAN
θ value	1.43324e-05 (rank : 12)	NC score	0.186994 (rank : 35)
Query Neighborhood Hits	156	Target Neighborhood Hits	362	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

ESM1_MOUSE
θ value	5.44631e-05 (rank : 13)	NC score	0.365976 (rank : 12)
Query Neighborhood Hits	156	Target Neighborhood Hits	107	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

CYR61_HUMAN
θ value	0.000270298 (rank : 14)	NC score	0.246512 (rank : 19)
Query Neighborhood Hits	156	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
θ value	0.000270298 (rank : 15)	NC score	0.246545 (rank : 18)
Query Neighborhood Hits	156	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

ESM1_HUMAN
θ value	0.000270298 (rank : 16)	NC score	0.343575 (rank : 13)
Query Neighborhood Hits	156	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

IBP3_HUMAN
θ value	0.00035302 (rank : 17)	NC score	0.239429 (rank : 22)
Query Neighborhood Hits	156	Target Neighborhood Hits	67	Shared Neighborhood Hits	36
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

CTGF_HUMAN
θ value	0.000461057 (rank : 18)	NC score	0.241737 (rank : 21)
Query Neighborhood Hits	156	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

AGRIN_HUMAN
θ value	0.00298849 (rank : 19)	NC score	0.109897 (rank : 76)
Query Neighborhood Hits	156	Target Neighborhood Hits	582	Shared Neighborhood Hits	53
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

WISP2_HUMAN
θ value	0.00509761 (rank : 20)	NC score	0.245697 (rank : 20)
Query Neighborhood Hits	156	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP3_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.221777 (rank : 25)
Query Neighborhood Hits	156	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

NOV_MOUSE
θ value	0.0193708 (rank : 22)	NC score	0.222216 (rank : 24)
Query Neighborhood Hits	156	Target Neighborhood Hits	130	Shared Neighborhood Hits	33
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

PDZD3_HUMAN
θ value	0.0193708 (rank : 23)	NC score	0.158463 (rank : 47)
Query Neighborhood Hits	156	Target Neighborhood Hits	180	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

MPDZ_MOUSE
θ value	0.0252991 (rank : 24)	NC score	0.110253 (rank : 73)
Query Neighborhood Hits	156	Target Neighborhood Hits	298	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PDZD3_MOUSE
θ value	0.0252991 (rank : 25)	NC score	0.161521 (rank : 43)
Query Neighborhood Hits	156	Target Neighborhood Hits	171	Shared Neighborhood Hits	68
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NOV_HUMAN
θ value	0.0330416 (rank : 26)	NC score	0.235121 (rank : 23)
Query Neighborhood Hits	156	Target Neighborhood Hits	128	Shared Neighborhood Hits	35
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

ARHGB_HUMAN
θ value	0.0431538 (rank : 27)	NC score	0.092769 (rank : 98)
Query Neighborhood Hits	156	Target Neighborhood Hits	375	Shared Neighborhood Hits	66
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GRN_HUMAN
θ value	0.0563607 (rank : 28)	NC score	0.056218 (rank : 171)
Query Neighborhood Hits	156	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

SDCB1_HUMAN
θ value	0.0563607 (rank : 29)	NC score	0.122151 (rank : 62)
Query Neighborhood Hits	156	Target Neighborhood Hits	150	Shared Neighborhood Hits	66
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

FSTL3_MOUSE
θ value	0.0736092 (rank : 30)	NC score	0.130062 (rank : 56)
Query Neighborhood Hits	156	Target Neighborhood Hits	152	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

ARHGC_HUMAN
θ value	0.125558 (rank : 31)	NC score	0.085301 (rank : 110)
Query Neighborhood Hits	156	Target Neighborhood Hits	351	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITB5_MOUSE
θ value	0.125558 (rank : 32)	NC score	0.044453 (rank : 183)
Query Neighborhood Hits	156	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	O70309, O70308, O88347	Gene names	Itgb5
Domain Architecture
Description	Integrin beta-5 precursor.

SDCB1_MOUSE
θ value	0.125558 (rank : 33)	NC score	0.118635 (rank : 66)
Query Neighborhood Hits	156	Target Neighborhood Hits	144	Shared Neighborhood Hits	67
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

ARHGC_MOUSE
θ value	0.163984 (rank : 34)	NC score	0.084609 (rank : 111)
Query Neighborhood Hits	156	Target Neighborhood Hits	344	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

IBP3_MOUSE
θ value	0.163984 (rank : 35)	NC score	0.190200 (rank : 33)
Query Neighborhood Hits	156	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

LAP4_HUMAN
θ value	0.163984 (rank : 36)	NC score	0.083445 (rank : 112)
Query Neighborhood Hits	156	Target Neighborhood Hits	608	Shared Neighborhood Hits	76
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PZRN4_HUMAN
θ value	0.163984 (rank : 37)	NC score	0.116713 (rank : 68)
Query Neighborhood Hits	156	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RPGF6_HUMAN
θ value	0.163984 (rank : 38)	NC score	0.093291 (rank : 95)
Query Neighborhood Hits	156	Target Neighborhood Hits	266	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

WISP1_MOUSE
θ value	0.163984 (rank : 39)	NC score	0.181300 (rank : 37)
Query Neighborhood Hits	156	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

ZO3_MOUSE
θ value	0.163984 (rank : 40)	NC score	0.120372 (rank : 63)
Query Neighborhood Hits	156	Target Neighborhood Hits	224	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GRN_MOUSE
θ value	0.21417 (rank : 41)	NC score	0.059630 (rank : 166)
Query Neighborhood Hits	156	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

TENN_HUMAN
θ value	0.21417 (rank : 42)	NC score	0.032888 (rank : 193)
Query Neighborhood Hits	156	Target Neighborhood Hits	453	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TICN2_MOUSE
θ value	0.21417 (rank : 43)	NC score	0.093113 (rank : 96)
Query Neighborhood Hits	156	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

WISP2_MOUSE
θ value	0.21417 (rank : 44)	NC score	0.211739 (rank : 26)
Query Neighborhood Hits	156	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

CTGF_MOUSE
θ value	0.279714 (rank : 45)	NC score	0.206216 (rank : 29)
Query Neighborhood Hits	156	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

IBP2_HUMAN
θ value	0.279714 (rank : 46)	NC score	0.206110 (rank : 30)
Query Neighborhood Hits	156	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

NOS1_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.063725 (rank : 154)
Query Neighborhood Hits	156	Target Neighborhood Hits	218	Shared Neighborhood Hits	61
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDZ11_HUMAN
θ value	0.279714 (rank : 48)	NC score	0.187600 (rank : 34)
Query Neighborhood Hits	156	Target Neighborhood Hits	160	Shared Neighborhood Hits	68
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	0.279714 (rank : 49)	NC score	0.186459 (rank : 36)
Query Neighborhood Hits	156	Target Neighborhood Hits	154	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD1_HUMAN
θ value	0.279714 (rank : 50)	NC score	0.170986 (rank : 39)
Query Neighborhood Hits	156	Target Neighborhood Hits	190	Shared Neighborhood Hits	75
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

USH1C_MOUSE
θ value	0.279714 (rank : 51)	NC score	0.123716 (rank : 60)
Query Neighborhood Hits	156	Target Neighborhood Hits	557	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

ZO2_HUMAN
θ value	0.279714 (rank : 52)	NC score	0.099310 (rank : 86)
Query Neighborhood Hits	156	Target Neighborhood Hits	289	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	0.279714 (rank : 53)	NC score	0.098544 (rank : 88)
Query Neighborhood Hits	156	Target Neighborhood Hits	296	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

IBP1_MOUSE
θ value	0.365318 (rank : 54)	NC score	0.202340 (rank : 31)
Query Neighborhood Hits	156	Target Neighborhood Hits	97	Shared Neighborhood Hits	39
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP5_HUMAN
θ value	0.365318 (rank : 55)	NC score	0.207319 (rank : 28)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	0.365318 (rank : 56)	NC score	0.207605 (rank : 27)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

PZRN3_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.109358 (rank : 77)
Query Neighborhood Hits	156	Target Neighborhood Hits	461	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

USH1C_HUMAN
θ value	0.365318 (rank : 58)	NC score	0.133678 (rank : 53)
Query Neighborhood Hits	156	Target Neighborhood Hits	327	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

DLG5_HUMAN
θ value	0.47712 (rank : 59)	NC score	0.067202 (rank : 145)
Query Neighborhood Hits	156	Target Neighborhood Hits	1088	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FSTL3_HUMAN
θ value	0.47712 (rank : 60)	NC score	0.134455 (rank : 52)
Query Neighborhood Hits	156	Target Neighborhood Hits	162	Shared Neighborhood Hits	32
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

IBP2_MOUSE
θ value	0.47712 (rank : 61)	NC score	0.195950 (rank : 32)
Query Neighborhood Hits	156	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

NHERF_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.148513 (rank : 48)
Query Neighborhood Hits	156	Target Neighborhood Hits	190	Shared Neighborhood Hits	71
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD1_MOUSE
θ value	0.47712 (rank : 63)	NC score	0.173485 (rank : 38)
Query Neighborhood Hits	156	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZK4_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.112647 (rank : 71)
Query Neighborhood Hits	156	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	0.47712 (rank : 65)	NC score	0.114974 (rank : 70)
Query Neighborhood Hits	156	Target Neighborhood Hits	165	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PZRN3_MOUSE
θ value	0.47712 (rank : 66)	NC score	0.110002 (rank : 75)
Query Neighborhood Hits	156	Target Neighborhood Hits	447	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

TENA_HUMAN
θ value	0.47712 (rank : 67)	NC score	0.030426 (rank : 195)
Query Neighborhood Hits	156	Target Neighborhood Hits	631	Shared Neighborhood Hits	33
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

WHRN_HUMAN
θ value	0.47712 (rank : 68)	NC score	0.133419 (rank : 54)
Query Neighborhood Hits	156	Target Neighborhood Hits	325	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	0.47712 (rank : 69)	NC score	0.133317 (rank : 55)
Query Neighborhood Hits	156	Target Neighborhood Hits	412	Shared Neighborhood Hits	73
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

GRIP2_HUMAN
θ value	0.62314 (rank : 70)	NC score	0.103747 (rank : 85)
Query Neighborhood Hits	156	Target Neighborhood Hits	256	Shared Neighborhood Hits	70
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

ITB4_HUMAN
θ value	0.62314 (rank : 71)	NC score	0.033809 (rank : 192)
Query Neighborhood Hits	156	Target Neighborhood Hits	458	Shared Neighborhood Hits	24
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

MPDZ_HUMAN
θ value	0.62314 (rank : 72)	NC score	0.105667 (rank : 81)
Query Neighborhood Hits	156	Target Neighborhood Hits	261	Shared Neighborhood Hits	72
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

RECK_MOUSE
θ value	0.62314 (rank : 73)	NC score	0.092724 (rank : 99)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

RHPN1_HUMAN
θ value	0.62314 (rank : 74)	NC score	0.110233 (rank : 74)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	0.62314 (rank : 75)	NC score	0.110368 (rank : 72)
Query Neighborhood Hits	156	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TICN2_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.090197 (rank : 107)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	30
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

ZO1_HUMAN
θ value	0.62314 (rank : 77)	NC score	0.104988 (rank : 83)
Query Neighborhood Hits	156	Target Neighborhood Hits	474	Shared Neighborhood Hits	69
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

LAP4_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.077680 (rank : 121)
Query Neighborhood Hits	156	Target Neighborhood Hits	590	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LCE1C_HUMAN
θ value	0.813845 (rank : 79)	NC score	0.289062 (rank : 15)
Query Neighborhood Hits	156	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1E_HUMAN
θ value	0.813845 (rank : 80)	NC score	0.316147 (rank : 14)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

ISK3_MOUSE
θ value	1.06291 (rank : 81)	NC score	0.137001 (rank : 51)
Query Neighborhood Hits	156	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

TENA_MOUSE
θ value	1.06291 (rank : 82)	NC score	0.028670 (rank : 198)
Query Neighborhood Hits	156	Target Neighborhood Hits	596	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

WISP1_HUMAN
θ value	1.06291 (rank : 83)	NC score	0.169279 (rank : 40)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	29
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

ZO1_MOUSE
θ value	1.06291 (rank : 84)	NC score	0.104663 (rank : 84)
Query Neighborhood Hits	156	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ADM1B_MOUSE
θ value	1.38821 (rank : 85)	NC score	0.011272 (rank : 213)
Query Neighborhood Hits	156	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

NHERF_MOUSE
θ value	1.38821 (rank : 86)	NC score	0.146128 (rank : 49)
Query Neighborhood Hits	156	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

RECK_HUMAN
θ value	1.38821 (rank : 87)	NC score	0.094351 (rank : 94)
Query Neighborhood Hits	156	Target Neighborhood Hits	189	Shared Neighborhood Hits	39
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

FSTL4_MOUSE
θ value	1.81305 (rank : 88)	NC score	0.052849 (rank : 178)
Query Neighborhood Hits	156	Target Neighborhood Hits	333	Shared Neighborhood Hits	29
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

GOPC_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.097514 (rank : 90)
Query Neighborhood Hits	156	Target Neighborhood Hits	377	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.099181 (rank : 87)
Query Neighborhood Hits	156	Target Neighborhood Hits	323	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

IBP4_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.165358 (rank : 41)
Query Neighborhood Hits	156	Target Neighborhood Hits	52	Shared Neighborhood Hits	30
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

ITB7_MOUSE
θ value	1.81305 (rank : 92)	NC score	0.034772 (rank : 190)
Query Neighborhood Hits	156	Target Neighborhood Hits	277	Shared Neighborhood Hits	24
SwissProt Accessions	P26011, Q3U2M1, Q64656	Gene names	Itgb7
Domain Architecture
Description	Integrin beta-7 precursor (Integrin beta-P) (M290 IEL antigen).

LAMA1_MOUSE
θ value	1.81305 (rank : 93)	NC score	0.021976 (rank : 205)
Query Neighborhood Hits	156	Target Neighborhood Hits	838	Shared Neighborhood Hits	27
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

NOS1_MOUSE
θ value	1.81305 (rank : 94)	NC score	0.047992 (rank : 182)
Query Neighborhood Hits	156	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

RPGF2_HUMAN
θ value	1.81305 (rank : 95)	NC score	0.078928 (rank : 119)
Query Neighborhood Hits	156	Target Neighborhood Hits	242	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SDCB2_HUMAN
θ value	1.81305 (rank : 96)	NC score	0.091004 (rank : 106)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

ZO3_HUMAN
θ value	1.81305 (rank : 97)	NC score	0.105217 (rank : 82)
Query Neighborhood Hits	156	Target Neighborhood Hits	219	Shared Neighborhood Hits	72
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GRIP1_HUMAN
θ value	2.36792 (rank : 98)	NC score	0.082521 (rank : 115)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	2.36792 (rank : 99)	NC score	0.082881 (rank : 114)
Query Neighborhood Hits	156	Target Neighborhood Hits	241	Shared Neighborhood Hits	67
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

K1849_MOUSE
θ value	2.36792 (rank : 100)	NC score	0.065570 (rank : 147)
Query Neighborhood Hits	156	Target Neighborhood Hits	335	Shared Neighborhood Hits	62
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PDZD2_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.086132 (rank : 109)
Query Neighborhood Hits	156	Target Neighborhood Hits	772	Shared Neighborhood Hits	68
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

TICN1_MOUSE
θ value	2.36792 (rank : 102)	NC score	0.080391 (rank : 117)
Query Neighborhood Hits	156	Target Neighborhood Hits	79	Shared Neighborhood Hits	32
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

AFAD_HUMAN
θ value	3.0926 (rank : 103)	NC score	0.062053 (rank : 158)
Query Neighborhood Hits	156	Target Neighborhood Hits	689	Shared Neighborhood Hits	62
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

IBP4_MOUSE
θ value	3.0926 (rank : 104)	NC score	0.160565 (rank : 44)
Query Neighborhood Hits	156	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

INADL_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.092975 (rank : 97)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	71
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

ISK5_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.077687 (rank : 120)
Query Neighborhood Hits	156	Target Neighborhood Hits	89	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

ITB5_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.039311 (rank : 185)
Query Neighborhood Hits	156	Target Neighborhood Hits	310	Shared Neighborhood Hits	23
SwissProt Accessions	P18084	Gene names	ITGB5
Domain Architecture
Description	Integrin beta-5 precursor.

LCE1D_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.264194 (rank : 16)
Query Neighborhood Hits	156	Target Neighborhood Hits	44	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

MDFI_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.039493 (rank : 184)
Query Neighborhood Hits	156	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

NHRF2_HUMAN
θ value	3.0926 (rank : 110)	NC score	0.129879 (rank : 57)
Query Neighborhood Hits	156	Target Neighborhood Hits	197	Shared Neighborhood Hits	68
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PDZD7_HUMAN
θ value	3.0926 (rank : 111)	NC score	0.122457 (rank : 61)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PTN13_MOUSE
θ value	3.0926 (rank : 112)	NC score	0.051647 (rank : 179)
Query Neighborhood Hits	156	Target Neighborhood Hits	426	Shared Neighborhood Hits	69
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

TENX_HUMAN
θ value	3.0926 (rank : 113)	NC score	0.034787 (rank : 189)
Query Neighborhood Hits	156	Target Neighborhood Hits	789	Shared Neighborhood Hits	44
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TX1B3_HUMAN
θ value	3.0926 (rank : 114)	NC score	0.127003 (rank : 58)
Query Neighborhood Hits	156	Target Neighborhood Hits	161	Shared Neighborhood Hits	66
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	3.0926 (rank : 115)	NC score	0.126292 (rank : 59)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

FOSL2_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.014966 (rank : 209)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	3
SwissProt Accessions	P15408	Gene names	FOSL2, FRA2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

FOSL2_MOUSE
θ value	4.03905 (rank : 117)	NC score	0.015239 (rank : 207)
Query Neighborhood Hits	156	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	P47930	Gene names	Fosl2, Fra-2, Fra2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

LIN7B_HUMAN
θ value	4.03905 (rank : 118)	NC score	0.096717 (rank : 92)
Query Neighborhood Hits	156	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MEGF6_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.036226 (rank : 187)
Query Neighborhood Hits	156	Target Neighborhood Hits	671	Shared Neighborhood Hits	53
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MPP2_HUMAN
θ value	4.03905 (rank : 120)	NC score	0.023881 (rank : 203)
Query Neighborhood Hits	156	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

NHRF2_MOUSE
θ value	4.03905 (rank : 121)	NC score	0.120032 (rank : 64)
Query Neighborhood Hits	156	Target Neighborhood Hits	194	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

SYNP2_HUMAN
θ value	4.03905 (rank : 122)	NC score	0.055342 (rank : 172)
Query Neighborhood Hits	156	Target Neighborhood Hits	323	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TICN3_MOUSE
θ value	4.03905 (rank : 123)	NC score	0.075057 (rank : 122)
Query Neighborhood Hits	156	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

WIF1_HUMAN
θ value	4.03905 (rank : 124)	NC score	0.024278 (rank : 202)
Query Neighborhood Hits	156	Target Neighborhood Hits	392	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

CILP2_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.015015 (rank : 208)
Query Neighborhood Hits	156	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LCE1B_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.250598 (rank : 17)
Query Neighborhood Hits	156	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LIN7B_MOUSE
θ value	5.27518 (rank : 127)	NC score	0.095033 (rank : 93)
Query Neighborhood Hits	156	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MIRO2_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.010527 (rank : 214)
Query Neighborhood Hits	156	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZN7	Gene names	Rhot2, Arht2
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 2 (EC 3.6.5.-) (MIRO-2) (Ras homolog gene family member T2).

SDCB2_MOUSE
θ value	5.27518 (rank : 129)	NC score	0.082106 (rank : 116)
Query Neighborhood Hits	156	Target Neighborhood Hits	118	Shared Neighborhood Hits	56
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

STAB1_HUMAN
θ value	5.27518 (rank : 130)	NC score	0.026972 (rank : 199)
Query Neighborhood Hits	156	Target Neighborhood Hits	546	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

SYNP2_MOUSE
θ value	5.27518 (rank : 131)	NC score	0.060659 (rank : 165)
Query Neighborhood Hits	156	Target Neighborhood Hits	252	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

TICN3_HUMAN
θ value	5.27518 (rank : 132)	NC score	0.067769 (rank : 144)
Query Neighborhood Hits	156	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

VWF_HUMAN
θ value	5.27518 (rank : 133)	NC score	0.029017 (rank : 197)
Query Neighborhood Hits	156	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

EGR4_HUMAN
θ value	6.88961 (rank : 134)	NC score	-0.003847 (rank : 217)
Query Neighborhood Hits	156	Target Neighborhood Hits	939	Shared Neighborhood Hits	3
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

FBLN2_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.015922 (rank : 206)
Query Neighborhood Hits	156	Target Neighborhood Hits	505	Shared Neighborhood Hits	29
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FST_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.107418 (rank : 78)
Query Neighborhood Hits	156	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

FST_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.106236 (rank : 80)
Query Neighborhood Hits	156	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

KR412_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.029951 (rank : 196)
Query Neighborhood Hits	156	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

KRA47_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.030467 (rank : 194)
Query Neighborhood Hits	156	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

LSR_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.012520 (rank : 210)
Query Neighborhood Hits	156	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

SHAN1_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.034063 (rank : 191)
Query Neighborhood Hits	156	Target Neighborhood Hits	1041	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TENN_MOUSE
θ value	6.88961 (rank : 142)	NC score	0.025139 (rank : 200)
Query Neighborhood Hits	156	Target Neighborhood Hits	484	Shared Neighborhood Hits	25
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TICN1_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.069602 (rank : 137)
Query Neighborhood Hits	156	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

WIF1_MOUSE
θ value	6.88961 (rank : 144)	NC score	0.024440 (rank : 201)
Query Neighborhood Hits	156	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

ECM2_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.008702 (rank : 215)
Query Neighborhood Hits	156	Target Neighborhood Hits	402	Shared Neighborhood Hits	11
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

EZH1_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.011623 (rank : 212)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
θ value	8.99809 (rank : 147)	NC score	0.012179 (rank : 211)
Query Neighborhood Hits	156	Target Neighborhood Hits	126	Shared Neighborhood Hits	11
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

FRAS1_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.036957 (rank : 186)
Query Neighborhood Hits	156	Target Neighborhood Hits	759	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

K1849_HUMAN
θ value	8.99809 (rank : 149)	NC score	0.067084 (rank : 146)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LIN7A_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.092564 (rank : 102)
Query Neighborhood Hits	156	Target Neighborhood Hits	193	Shared Neighborhood Hits	70
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.092630 (rank : 101)
Query Neighborhood Hits	156	Target Neighborhood Hits	193	Shared Neighborhood Hits	70
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7C_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.091383 (rank : 103)
Query Neighborhood Hits	156	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.091383 (rank : 104)
Query Neighborhood Hits	156	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LMO7_HUMAN
θ value	8.99809 (rank : 154)	NC score	0.022233 (rank : 204)
Query Neighborhood Hits	156	Target Neighborhood Hits	507	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

SPRL1_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.035545 (rank : 188)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	21
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

TIE2_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.002137 (rank : 216)
Query Neighborhood Hits	156	Target Neighborhood Hits	1192	Shared Neighborhood Hits	24
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

DLG1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.071218 (rank : 129)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	66
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.070901 (rank : 132)
Query Neighborhood Hits	156	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.069742 (rank : 136)
Query Neighborhood Hits	156	Target Neighborhood Hits	279	Shared Neighborhood Hits	66
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.069068 (rank : 139)
Query Neighborhood Hits	156	Target Neighborhood Hits	271	Shared Neighborhood Hits	65
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.070261 (rank : 135)
Query Neighborhood Hits	156	Target Neighborhood Hits	269	Shared Neighborhood Hits	67
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.070676 (rank : 133)
Query Neighborhood Hits	156	Target Neighborhood Hits	274	Shared Neighborhood Hits	67
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.072450 (rank : 126)
Query Neighborhood Hits	156	Target Neighborhood Hits	286	Shared Neighborhood Hits	67
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.072528 (rank : 125)
Query Neighborhood Hits	156	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

FSTL1_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.064623 (rank : 149)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.063324 (rank : 156)
Query Neighborhood Hits	156	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

GRASP_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.079074 (rank : 118)
Query Neighborhood Hits	156	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.074378 (rank : 123)
Query Neighborhood Hits	156	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

IBP1_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.158639 (rank : 46)
Query Neighborhood Hits	156	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP6_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.098383 (rank : 89)
Query Neighborhood Hits	156	Target Neighborhood Hits	55	Shared Neighborhood Hits	19
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP6_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.092675 (rank : 100)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IL16_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.061595 (rank : 162)
Query Neighborhood Hits	156	Target Neighborhood Hits	207	Shared Neighborhood Hits	57
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.061094 (rank : 163)
Query Neighborhood Hits	156	Target Neighborhood Hits	189	Shared Neighborhood Hits	58
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INADL_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.087914 (rank : 108)
Query Neighborhood Hits	156	Target Neighborhood Hits	260	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

IPK1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.107165 (rank : 79)
Query Neighborhood Hits	156	Target Neighborhood Hits	38	Shared Neighborhood Hits	18
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

ISK6_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.061964 (rank : 159)
Query Neighborhood Hits	156	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK6_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.072391 (rank : 127)
Query Neighborhood Hits	156	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

KR171_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.051613 (rank : 180)
Query Neighborhood Hits	156	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

KR511_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.052959 (rank : 177)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

KRA53_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.053583 (rank : 176)
Query Neighborhood Hits	156	Target Neighborhood Hits	331	Shared Neighborhood Hits	32
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA56_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.060803 (rank : 164)
Query Neighborhood Hits	156	Target Neighborhood Hits	207	Shared Neighborhood Hits	25
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

LCE1A_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.163492 (rank : 42)
Query Neighborhood Hits	156	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1F_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.158907 (rank : 45)
Query Neighborhood Hits	156	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE2A_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.083202 (rank : 113)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

LCE2B_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.117974 (rank : 67)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2C_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.096758 (rank : 91)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.119800 (rank : 65)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE4A_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.115374 (rank : 69)
Query Neighborhood Hits	156	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

LCE5A_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.137811 (rank : 50)
Query Neighborhood Hits	156	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

LNX1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.064535 (rank : 150)
Query Neighborhood Hits	156	Target Neighborhood Hits	379	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.069207 (rank : 138)
Query Neighborhood Hits	156	Target Neighborhood Hits	377	Shared Neighborhood Hits	63
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.068296 (rank : 141)
Query Neighborhood Hits	156	Target Neighborhood Hits	389	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.070576 (rank : 134)
Query Neighborhood Hits	156	Target Neighborhood Hits	407	Shared Neighborhood Hits	65
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MAGI1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.071463 (rank : 128)
Query Neighborhood Hits	156	Target Neighborhood Hits	388	Shared Neighborhood Hits	69
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.071158 (rank : 130)
Query Neighborhood Hits	156	Target Neighborhood Hits	403	Shared Neighborhood Hits	69
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.062148 (rank : 157)
Query Neighborhood Hits	156	Target Neighborhood Hits	373	Shared Neighborhood Hits	67
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.064084 (rank : 151)
Query Neighborhood Hits	156	Target Neighborhood Hits	370	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PAR3L_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.073127 (rank : 124)
Query Neighborhood Hits	156	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.068904 (rank : 140)
Query Neighborhood Hits	156	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.068248 (rank : 142)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	62
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDLI2_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.050329 (rank : 181)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PSCBP_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.065097 (rank : 148)
Query Neighborhood Hits	156	Target Neighborhood Hits	123	Shared Neighborhood Hits	59
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PSCBP_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.054707 (rank : 173)
Query Neighborhood Hits	156	Target Neighborhood Hits	118	Shared Neighborhood Hits	55
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SMOC1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.057128 (rank : 169)
Query Neighborhood Hits	156	Target Neighborhood Hits	74	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SNTA1_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.058504 (rank : 167)
Query Neighborhood Hits	156	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.056480 (rank : 170)
Query Neighborhood Hits	156	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SNTB1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.053934 (rank : 175)
Query Neighborhood Hits	156	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.053951 (rank : 174)
Query Neighborhood Hits	156	Target Neighborhood Hits	160	Shared Neighborhood Hits	60
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB2_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.063721 (rank : 155)
Query Neighborhood Hits	156	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.063860 (rank : 153)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	66
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.061680 (rank : 161)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.061718 (rank : 160)
Query Neighborhood Hits	156	Target Neighborhood Hits	179	Shared Neighborhood Hits	65
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.064041 (rank : 152)
Query Neighborhood Hits	156	Target Neighborhood Hits	191	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG2_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.058443 (rank : 168)
Query Neighborhood Hits	156	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.091005 (rank : 105)
Query Neighborhood Hits	156	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

TEFF2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.067782 (rank : 143)
Query Neighborhood Hits	156	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.071043 (rank : 131)
Query Neighborhood Hits	156	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

Hits sorted by NC score

HTRA3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	156	Target Neighborhood Hits	156	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA3_HUMAN
NC score	0.993220 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	156	Target Neighborhood Hits	152	Shared Neighborhood Hits	128
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA1_MOUSE
NC score	0.960934 (rank : 3)	θ value	1.63136e-134 (rank : 4)
Query Neighborhood Hits	156	Target Neighborhood Hits	140	Shared Neighborhood Hits	93
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA4_HUMAN
NC score	0.956735 (rank : 4)	θ value	9.30652e-114 (rank : 5)
Query Neighborhood Hits	156	Target Neighborhood Hits	119	Shared Neighborhood Hits	74
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA1_HUMAN
NC score	0.955822 (rank : 5)	θ value	2.87295e-139 (rank : 3)
Query Neighborhood Hits	156	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA2_MOUSE
NC score	0.904267 (rank : 6)	θ value	5.86991e-92 (rank : 7)
Query Neighborhood Hits	156	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
NC score	0.902841 (rank : 7)	θ value	5.86991e-92 (rank : 6)
Query Neighborhood Hits	156	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_MOUSE
NC score	0.481812 (rank : 8)	θ value	5.8054e-15 (rank : 8)
Query Neighborhood Hits	156	Target Neighborhood Hits	230	Shared Neighborhood Hits	37
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IBP7_HUMAN
NC score	0.481350 (rank : 9)	θ value	1.68911e-14 (rank : 9)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	37
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

KAZD1_HUMAN
NC score	0.422747 (rank : 10)	θ value	3.52202e-12 (rank : 11)
Query Neighborhood Hits	156	Target Neighborhood Hits	248	Shared Neighborhood Hits	46
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
NC score	0.400929 (rank : 11)	θ value	1.2105e-12 (rank : 10)
Query Neighborhood Hits	156	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

ESM1_MOUSE
NC score	0.365976 (rank : 12)	θ value	5.44631e-05 (rank : 13)
Query Neighborhood Hits	156	Target Neighborhood Hits	107	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_HUMAN
NC score	0.343575 (rank : 13)	θ value	0.000270298 (rank : 16)
Query Neighborhood Hits	156	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

LCE1E_HUMAN
NC score	0.316147 (rank : 14)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1C_HUMAN
NC score	0.289062 (rank : 15)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	156	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
NC score	0.264194 (rank : 16)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	156	Target Neighborhood Hits	44	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1B_HUMAN
NC score	0.250598 (rank : 17)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	156	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

CYR61_MOUSE
NC score	0.246545 (rank : 18)	θ value	0.000270298 (rank : 15)
Query Neighborhood Hits	156	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CYR61_HUMAN
NC score	0.246512 (rank : 19)	θ value	0.000270298 (rank : 14)
Query Neighborhood Hits	156	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

WISP2_HUMAN
NC score	0.245697 (rank : 20)	θ value	0.00509761 (rank : 20)
Query Neighborhood Hits	156	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

CTGF_HUMAN
NC score	0.241737 (rank : 21)	θ value	0.000461057 (rank : 18)
Query Neighborhood Hits	156	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

IBP3_HUMAN
NC score	0.239429 (rank : 22)	θ value	0.00035302 (rank : 17)
Query Neighborhood Hits	156	Target Neighborhood Hits	67	Shared Neighborhood Hits	36
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

NOV_HUMAN
NC score	0.235121 (rank : 23)	θ value	0.0330416 (rank : 26)
Query Neighborhood Hits	156	Target Neighborhood Hits	128	Shared Neighborhood Hits	35
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
NC score	0.222216 (rank : 24)	θ value	0.0193708 (rank : 22)
Query Neighborhood Hits	156	Target Neighborhood Hits	130	Shared Neighborhood Hits	33
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP3_HUMAN
NC score	0.221777 (rank : 25)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	156	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

WISP2_MOUSE
NC score	0.211739 (rank : 26)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	156	Target Neighborhood Hits	129	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

IBP5_MOUSE
NC score	0.207605 (rank : 27)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	38
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_HUMAN
NC score	0.207319 (rank : 28)	θ value	0.365318 (rank : 55)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

CTGF_MOUSE
NC score	0.206216 (rank : 29)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	156	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

IBP2_HUMAN
NC score	0.206110 (rank : 30)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	156	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP1_MOUSE
NC score	0.202340 (rank : 31)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	156	Target Neighborhood Hits	97	Shared Neighborhood Hits	39
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP2_MOUSE
NC score	0.195950 (rank : 32)	θ value	0.47712 (rank : 61)
Query Neighborhood Hits	156	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP3_MOUSE
NC score	0.190200 (rank : 33)	θ value	0.163984 (rank : 35)
Query Neighborhood Hits	156	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

PDZ11_HUMAN
NC score	0.187600 (rank : 34)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	156	Target Neighborhood Hits	160	Shared Neighborhood Hits	68
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

CRIM1_HUMAN
NC score	0.186994 (rank : 35)	θ value	1.43324e-05 (rank : 12)
Query Neighborhood Hits	156	Target Neighborhood Hits	362	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

PDZ11_MOUSE
NC score	0.186459 (rank : 36)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	156	Target Neighborhood Hits	154	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

WISP1_MOUSE
NC score	0.181300 (rank : 37)	θ value	0.163984 (rank : 39)
Query Neighborhood Hits	156	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

PDZD1_MOUSE
NC score	0.173485 (rank : 38)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	156	Target Neighborhood Hits	191	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_HUMAN
NC score	0.170986 (rank : 39)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	156	Target Neighborhood Hits	190	Shared Neighborhood Hits	75
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

WISP1_HUMAN
NC score	0.169279 (rank : 40)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	29
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

IBP4_HUMAN
NC score	0.165358 (rank : 41)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	156	Target Neighborhood Hits	52	Shared Neighborhood Hits	30
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

LCE1A_HUMAN
NC score	0.163492 (rank : 42)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	156	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

PDZD3_MOUSE
NC score	0.161521 (rank : 43)	θ value	0.0252991 (rank : 25)
Query Neighborhood Hits	156	Target Neighborhood Hits	171	Shared Neighborhood Hits	68
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

IBP4_MOUSE
NC score	0.160565 (rank : 44)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	156	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

LCE1F_HUMAN
NC score	0.158907 (rank : 45)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	156	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

IBP1_HUMAN
NC score	0.158639 (rank : 46)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	156	Target Neighborhood Hits	67	Shared Neighborhood Hits	40
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

PDZD3_HUMAN
NC score	0.158463 (rank : 47)	θ value	0.0193708 (rank : 23)
Query Neighborhood Hits	156	Target Neighborhood Hits	180	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

NHERF_HUMAN
NC score	0.148513 (rank : 48)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	156	Target Neighborhood Hits	190	Shared Neighborhood Hits	71
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
NC score	0.146128 (rank : 49)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	156	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

LCE5A_HUMAN
NC score	0.137811 (rank : 50)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	156	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

ISK3_MOUSE
NC score	0.137001 (rank : 51)	θ value	1.06291 (rank : 81)
Query Neighborhood Hits	156	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

FSTL3_HUMAN
NC score	0.134455 (rank : 52)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	156	Target Neighborhood Hits	162	Shared Neighborhood Hits	32
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

USH1C_HUMAN
NC score	0.133678 (rank : 53)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	156	Target Neighborhood Hits	327	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

WHRN_HUMAN
NC score	0.133419 (rank : 54)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	156	Target Neighborhood Hits	325	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.133317 (rank : 55)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	156	Target Neighborhood Hits	412	Shared Neighborhood Hits	73
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

FSTL3_MOUSE
NC score	0.130062 (rank : 56)	θ value	0.0736092 (rank : 30)
Query Neighborhood Hits	156	Target Neighborhood Hits	152	Shared Neighborhood Hits	31
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

NHRF2_HUMAN
NC score	0.129879 (rank : 57)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	156	Target Neighborhood Hits	197	Shared Neighborhood Hits	68
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

TX1B3_HUMAN
NC score	0.127003 (rank : 58)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	156	Target Neighborhood Hits	161	Shared Neighborhood Hits	66
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.126292 (rank : 59)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_MOUSE
NC score	0.123716 (rank : 60)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	156	Target Neighborhood Hits	557	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZD7_HUMAN
NC score	0.122457 (rank : 61)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SDCB1_HUMAN
NC score	0.122151 (rank : 62)	θ value	0.0563607 (rank : 29)
Query Neighborhood Hits	156	Target Neighborhood Hits	150	Shared Neighborhood Hits	66
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

ZO3_MOUSE
NC score	0.120372 (rank : 63)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	156	Target Neighborhood Hits	224	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

NHRF2_MOUSE
NC score	0.120032 (rank : 64)	θ value	4.03905 (rank : 121)
Query Neighborhood Hits	156	Target Neighborhood Hits	194	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

LCE2D_HUMAN
NC score	0.119800 (rank : 65)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

SDCB1_MOUSE
NC score	0.118635 (rank : 66)	θ value	0.125558 (rank : 33)
Query Neighborhood Hits	156	Target Neighborhood Hits	144	Shared Neighborhood Hits	67
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

LCE2B_HUMAN
NC score	0.117974 (rank : 67)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	8
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

PZRN4_HUMAN
NC score	0.116713 (rank : 68)	θ value	0.163984 (rank : 37)
Query Neighborhood Hits	156	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LCE4A_HUMAN
NC score	0.115374 (rank : 69)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	156	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

PDZK4_MOUSE
NC score	0.114974 (rank : 70)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	156	Target Neighborhood Hits	165	Shared Neighborhood Hits	62
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.112647 (rank : 71)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	156	Target Neighborhood Hits	165	Shared Neighborhood Hits	61
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

RHPN1_MOUSE
NC score	0.110368 (rank : 72)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	156	Target Neighborhood Hits	154	Shared Neighborhood Hits	64
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

MPDZ_MOUSE
NC score	0.110253 (rank : 73)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	156	Target Neighborhood Hits	298	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

RHPN1_HUMAN
NC score	0.110233 (rank : 74)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PZRN3_MOUSE
NC score	0.110002 (rank : 75)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	156	Target Neighborhood Hits	447	Shared Neighborhood Hits	67
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

AGRIN_HUMAN
NC score	0.109897 (rank : 76)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	156	Target Neighborhood Hits	582	Shared Neighborhood Hits	53
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

PZRN3_HUMAN
NC score	0.109358 (rank : 77)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	156	Target Neighborhood Hits	461	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

FST_HUMAN
NC score	0.107418 (rank : 78)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	156	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

IPK1_HUMAN
NC score	0.107165 (rank : 79)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	156	Target Neighborhood Hits	38	Shared Neighborhood Hits	18
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

FST_MOUSE
NC score	0.106236 (rank : 80)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	156	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

MPDZ_HUMAN
NC score	0.105667 (rank : 81)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	156	Target Neighborhood Hits	261	Shared Neighborhood Hits	72
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ZO3_HUMAN
NC score	0.105217 (rank : 82)	θ value	1.81305 (rank : 97)
Query Neighborhood Hits	156	Target Neighborhood Hits	219	Shared Neighborhood Hits	72
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO1_HUMAN
NC score	0.104988 (rank : 83)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	156	Target Neighborhood Hits	474	Shared Neighborhood Hits	69
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
NC score	0.104663 (rank : 84)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	156	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

GRIP2_HUMAN
NC score	0.103747 (rank : 85)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	156	Target Neighborhood Hits	256	Shared Neighborhood Hits	70
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

ZO2_HUMAN
NC score	0.099310 (rank : 86)	θ value	0.279714 (rank : 52)
Query Neighborhood Hits	156	Target Neighborhood Hits	289	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

GOPC_MOUSE
NC score	0.099181 (rank : 87)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	156	Target Neighborhood Hits	323	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

ZO2_MOUSE
NC score	0.098544 (rank : 88)	θ value	0.279714 (rank : 53)
Query Neighborhood Hits	156	Target Neighborhood Hits	296	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

IBP6_HUMAN
NC score	0.098383 (rank : 89)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	156	Target Neighborhood Hits	55	Shared Neighborhood Hits	19
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

GOPC_HUMAN
NC score	0.097514 (rank : 90)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	156	Target Neighborhood Hits	377	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

LCE2C_HUMAN
NC score	0.096758 (rank : 91)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LIN7B_HUMAN
NC score	0.096717 (rank : 92)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	156	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.095033 (rank : 93)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	156	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

RECK_HUMAN
NC score	0.094351 (rank : 94)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	156	Target Neighborhood Hits	189	Shared Neighborhood Hits	39
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RPGF6_HUMAN
NC score	0.093291 (rank : 95)	θ value	0.163984 (rank : 38)
Query Neighborhood Hits	156	Target Neighborhood Hits	266	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TICN2_MOUSE
NC score	0.093113 (rank : 96)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	156	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

INADL_MOUSE
NC score	0.092975 (rank : 97)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	71
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

ARHGB_HUMAN
NC score	0.092769 (rank : 98)	θ value	0.0431538 (rank : 27)
Query Neighborhood Hits	156	Target Neighborhood Hits	375	Shared Neighborhood Hits	66
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

RECK_MOUSE
NC score	0.092724 (rank : 99)	θ value	0.62314 (rank : 73)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

IBP6_MOUSE
NC score	0.092675 (rank : 100)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	156	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

LIN7A_MOUSE
NC score	0.092630 (rank : 101)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	156	Target Neighborhood Hits	193	Shared Neighborhood Hits	70
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.092564 (rank : 102)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	156	Target Neighborhood Hits	193	Shared Neighborhood Hits	70
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7C_HUMAN
NC score	0.091383 (rank : 103)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	156	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.091383 (rank : 104)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	156	Target Neighborhood Hits	198	Shared Neighborhood Hits	71
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

SYJ2B_HUMAN
NC score	0.091005 (rank : 105)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	156	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

SDCB2_HUMAN
NC score	0.091004 (rank : 106)	θ value	1.81305 (rank : 96)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TICN2_HUMAN
NC score	0.090197 (rank : 107)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	30
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

INADL_HUMAN
NC score	0.087914 (rank : 108)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	156	Target Neighborhood Hits	260	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

PDZD2_HUMAN
NC score	0.086132 (rank : 109)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	156	Target Neighborhood Hits	772	Shared Neighborhood Hits	68
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

ARHGC_HUMAN
NC score	0.085301 (rank : 110)	θ value	0.125558 (rank : 31)
Query Neighborhood Hits	156	Target Neighborhood Hits	351	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.084609 (rank : 111)	θ value	0.163984 (rank : 34)
Query Neighborhood Hits	156	Target Neighborhood Hits	344	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LAP4_HUMAN
NC score	0.083445 (rank : 112)	θ value	0.163984 (rank : 36)
Query Neighborhood Hits	156	Target Neighborhood Hits	608	Shared Neighborhood Hits	76
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LCE2A_HUMAN
NC score	0.083202 (rank : 113)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	156	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

GRIP1_MOUSE
NC score	0.082881 (rank : 114)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	156	Target Neighborhood Hits	241	Shared Neighborhood Hits	67
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_HUMAN
NC score	0.082521 (rank : 115)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

SDCB2_MOUSE
NC score	0.082106 (rank : 116)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	156	Target Neighborhood Hits	118	Shared Neighborhood Hits	56
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TICN1_MOUSE
NC score	0.080391 (rank : 117)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	156	Target Neighborhood Hits	79	Shared Neighborhood Hits	32
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

GRASP_HUMAN
NC score	0.079074 (rank : 118)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	156	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

RPGF2_HUMAN
NC score	0.078928 (rank : 119)	θ value	1.81305 (rank : 95)
Query Neighborhood Hits	156	Target Neighborhood Hits	242	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

ISK5_HUMAN
NC score	0.077687 (rank : 120)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	156	Target Neighborhood Hits	89	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

LAP4_MOUSE
NC score	0.077680 (rank : 121)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	156	Target Neighborhood Hits	590	Shared Neighborhood Hits	75
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

TICN3_MOUSE
NC score	0.075057 (rank : 122)	θ value	4.03905 (rank : 123)
Query Neighborhood Hits	156	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

GRASP_MOUSE
NC score	0.074378 (rank : 123)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	156	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PAR3L_HUMAN
NC score	0.073127 (rank : 124)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	156	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

DLG4_MOUSE
NC score	0.072528 (rank : 125)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	156	Target Neighborhood Hits	282	Shared Neighborhood Hits	67
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.072450 (rank : 126)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	156	Target Neighborhood Hits	286	Shared Neighborhood Hits	67
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

ISK6_MOUSE
NC score	0.072391 (rank : 127)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	156	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

MAGI1_HUMAN
NC score	0.071463 (rank : 128)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	156	Target Neighborhood Hits	388	Shared Neighborhood Hits	69
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

DLG1_HUMAN
NC score	0.071218 (rank : 129)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	66
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

MAGI1_MOUSE
NC score	0.071158 (rank : 130)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	156	Target Neighborhood Hits	403	Shared Neighborhood Hits	69
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

TEFF2_MOUSE
NC score	0.071043 (rank : 131)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	156	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

DLG1_MOUSE
NC score	0.070901 (rank : 132)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	156	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG3_MOUSE
NC score	0.070676 (rank : 133)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	156	Target Neighborhood Hits	274	Shared Neighborhood Hits	67
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

LNX2_MOUSE
NC score	0.070576 (rank : 134)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	156	Target Neighborhood Hits	407	Shared Neighborhood Hits	65
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

DLG3_HUMAN
NC score	0.070261 (rank : 135)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	156	Target Neighborhood Hits	269	Shared Neighborhood Hits	67
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG2_HUMAN
NC score	0.069742 (rank : 136)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	156	Target Neighborhood Hits	279	Shared Neighborhood Hits	66
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

TICN1_HUMAN
NC score	0.069602 (rank : 137)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	156	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

LNX1_MOUSE
NC score	0.069207 (rank : 138)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	156	Target Neighborhood Hits	377	Shared Neighborhood Hits	63
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

DLG2_MOUSE
NC score	0.069068 (rank : 139)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	156	Target Neighborhood Hits	271	Shared Neighborhood Hits	65
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PARD3_HUMAN
NC score	0.068904 (rank : 140)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	156	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

LNX2_HUMAN
NC score	0.068296 (rank : 141)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	156	Target Neighborhood Hits	389	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

PARD3_MOUSE
NC score	0.068248 (rank : 142)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	156	Target Neighborhood Hits	290	Shared Neighborhood Hits	62
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

TEFF2_HUMAN
NC score	0.067782 (rank : 143)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	156	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TICN3_HUMAN
NC score	0.067769 (rank : 144)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	156	Target Neighborhood Hits	82	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

DLG5_HUMAN
NC score	0.067202 (rank : 145)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	156	Target Neighborhood Hits	1088	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

K1849_HUMAN
NC score	0.067084 (rank : 146)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
NC score	0.065570 (rank : 147)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	156	Target Neighborhood Hits	335	Shared Neighborhood Hits	62
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PSCBP_HUMAN
NC score	0.065097 (rank : 148)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	156	Target Neighborhood Hits	123	Shared Neighborhood Hits	59
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

FSTL1_HUMAN
NC score	0.064623 (rank : 149)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	156	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

LNX1_HUMAN
NC score	0.064535 (rank : 150)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	156	Target Neighborhood Hits	379	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MAGI2_MOUSE
NC score	0.064084 (rank : 151)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	156	Target Neighborhood Hits	370	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

SNTG2_HUMAN
NC score	0.064041 (rank : 152)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	156	Target Neighborhood Hits	191	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTB2_MOUSE
NC score	0.063860 (rank : 153)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	66
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

NOS1_HUMAN
NC score	0.063725 (rank : 154)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	156	Target Neighborhood Hits	218	Shared Neighborhood Hits	61
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SNTB2_HUMAN
NC score	0.063721 (rank : 155)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	156	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

FSTL1_MOUSE
NC score	0.063324 (rank : 156)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	156	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

MAGI2_HUMAN
NC score	0.062148 (rank : 157)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	156	Target Neighborhood Hits	373	Shared Neighborhood Hits	67
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

AFAD_HUMAN
NC score	0.062053 (rank : 158)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	156	Target Neighborhood Hits	689	Shared Neighborhood Hits	62
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

ISK6_HUMAN
NC score	0.061964 (rank : 159)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	156	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

SNTG1_MOUSE
NC score	0.061718 (rank : 160)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	156	Target Neighborhood Hits	179	Shared Neighborhood Hits	65
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_HUMAN
NC score	0.061680 (rank : 161)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	156	Target Neighborhood Hits	181	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

IL16_HUMAN
NC score	0.061595 (rank : 162)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	156	Target Neighborhood Hits	207	Shared Neighborhood Hits	57
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IL16_MOUSE
NC score	0.061094 (rank : 163)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	156	Target Neighborhood Hits	189	Shared Neighborhood Hits	58
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KRA56_HUMAN
NC score	0.060803 (rank : 164)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	156	Target Neighborhood Hits	207	Shared Neighborhood Hits	25
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

SYNP2_MOUSE
NC score	0.060659 (rank : 165)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	156	Target Neighborhood Hits	252	Shared Neighborhood Hits	56
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

GRN_MOUSE
NC score	0.059630 (rank : 166)	θ value	0.21417 (rank : 41)
Query Neighborhood Hits	156	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

SNTA1_HUMAN
NC score	0.058504 (rank : 167)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	156	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTG2_MOUSE
NC score	0.058443 (rank : 168)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	156	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SMOC1_MOUSE
NC score	0.057128 (rank : 169)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	156	Target Neighborhood Hits	74	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SNTA1_MOUSE
NC score	0.056480 (rank : 170)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	156	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

GRN_HUMAN
NC score	0.056218 (rank : 171)	θ value	0.0563607 (rank : 28)
Query Neighborhood Hits	156	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

SYNP2_HUMAN
NC score	0.055342 (rank : 172)	θ value	4.03905 (rank : 122)
Query Neighborhood Hits	156	Target Neighborhood Hits	323	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

PSCBP_MOUSE
NC score	0.054707 (rank : 173)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	156	Target Neighborhood Hits	118	Shared Neighborhood Hits	55
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SNTB1_MOUSE
NC score	0.053951 (rank : 174)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	156	Target Neighborhood Hits	160	Shared Neighborhood Hits	60
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB1_HUMAN
NC score	0.053934 (rank : 175)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	156	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

KRA53_HUMAN
NC score	0.053583 (rank : 176)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	156	Target Neighborhood Hits	331	Shared Neighborhood Hits	32
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KR511_HUMAN
NC score	0.052959 (rank : 177)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

FSTL4_MOUSE
NC score	0.052849 (rank : 178)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	156	Target Neighborhood Hits	333	Shared Neighborhood Hits	29
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

PTN13_MOUSE
NC score	0.051647 (rank : 179)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	156	Target Neighborhood Hits	426	Shared Neighborhood Hits	69
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

KR171_HUMAN
NC score	0.051613 (rank : 180)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	156	Target Neighborhood Hits	144	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

PDLI2_MOUSE
NC score	0.050329 (rank : 181)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	156	Target Neighborhood Hits	220	Shared Neighborhood Hits	55
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

NOS1_MOUSE
NC score	0.047992 (rank : 182)	θ value	1.81305 (rank : 94)
Query Neighborhood Hits	156	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ITB5_MOUSE
NC score	0.044453 (rank : 183)	θ value	0.125558 (rank : 32)
Query Neighborhood Hits	156	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	O70309, O70308, O88347	Gene names	Itgb5
Domain Architecture
Description	Integrin beta-5 precursor.

MDFI_HUMAN
NC score	0.039493 (rank : 184)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	156	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

ITB5_HUMAN
NC score	0.039311 (rank : 185)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	156	Target Neighborhood Hits	310	Shared Neighborhood Hits	23
SwissProt Accessions	P18084	Gene names	ITGB5
Domain Architecture
Description	Integrin beta-5 precursor.

FRAS1_HUMAN
NC score	0.036957 (rank : 186)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	156	Target Neighborhood Hits	759	Shared Neighborhood Hits	44
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

MEGF6_HUMAN
NC score	0.036226 (rank : 187)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	156	Target Neighborhood Hits	671	Shared Neighborhood Hits	53
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

SPRL1_HUMAN
NC score	0.035545 (rank : 188)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	156	Target Neighborhood Hits	231	Shared Neighborhood Hits	21
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

TENX_HUMAN
NC score	0.034787 (rank : 189)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	156	Target Neighborhood Hits	789	Shared Neighborhood Hits	44
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ITB7_MOUSE
NC score	0.034772 (rank : 190)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	156	Target Neighborhood Hits	277	Shared Neighborhood Hits	24
SwissProt Accessions	P26011, Q3U2M1, Q64656	Gene names	Itgb7
Domain Architecture
Description	Integrin beta-7 precursor (Integrin beta-P) (M290 IEL antigen).

SHAN1_HUMAN
NC score	0.034063 (rank : 191)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	156	Target Neighborhood Hits	1041	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ITB4_HUMAN
NC score	0.033809 (rank : 192)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	156	Target Neighborhood Hits	458	Shared Neighborhood Hits	24
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

TENN_HUMAN
NC score	0.032888 (rank : 193)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	156	Target Neighborhood Hits	453	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

KRA47_HUMAN
NC score	0.030467 (rank : 194)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	156	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

TENA_HUMAN
NC score	0.030426 (rank : 195)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	156	Target Neighborhood Hits	631	Shared Neighborhood Hits	33
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

KR412_HUMAN
NC score	0.029951 (rank : 196)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	156	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

VWF_HUMAN
NC score	0.029017 (rank : 197)	θ value	5.27518 (rank : 133)
Query Neighborhood Hits	156	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

TENA_MOUSE
NC score	0.028670 (rank : 198)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	156	Target Neighborhood Hits	596	Shared Neighborhood Hits	31
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

STAB1_HUMAN
NC score	0.026972 (rank : 199)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	156	Target Neighborhood Hits	546	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

TENN_MOUSE
NC score	0.025139 (rank : 200)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	156	Target Neighborhood Hits	484	Shared Neighborhood Hits	25
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

WIF1_MOUSE
NC score	0.024440 (rank : 201)	θ value	6.88961 (rank : 144)
Query Neighborhood Hits	156	Target Neighborhood Hits	393	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

WIF1_HUMAN
NC score	0.024278 (rank : 202)	θ value	4.03905 (rank : 124)
Query Neighborhood Hits	156	Target Neighborhood Hits	392	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

MPP2_HUMAN
NC score	0.023881 (rank : 203)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	156	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

LMO7_HUMAN
NC score	0.022233 (rank : 204)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	156	Target Neighborhood Hits	507	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LAMA1_MOUSE
NC score	0.021976 (rank : 205)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	156	Target Neighborhood Hits	838	Shared Neighborhood Hits	27
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

FBLN2_MOUSE
NC score	0.015922 (rank : 206)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	156	Target Neighborhood Hits	505	Shared Neighborhood Hits	29
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FOSL2_MOUSE
NC score	0.015239 (rank : 207)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	156	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	P47930	Gene names	Fosl2, Fra-2, Fra2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

CILP2_HUMAN
NC score	0.015015 (rank : 208)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	156	Target Neighborhood Hits	307	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

FOSL2_HUMAN
NC score	0.014966 (rank : 209)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	156	Target Neighborhood Hits	158	Shared Neighborhood Hits	3
SwissProt Accessions	P15408	Gene names	FOSL2, FRA2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

LSR_MOUSE
NC score	0.012520 (rank : 210)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	156	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KG5, Q3TJE7, Q3UIQ9, Q61148, Q61149, Q6U816	Gene names	Lsr, Lisch7
Domain Architecture	No domain graphic available
Description	Lipolysis-stimulated lipoprotein receptor precursor (Liver-specific bHLH-Zip transcription factor) (Lipolysis-stimulated receptor) (Liver- specific gene on mouse chromosome 7 protein).

EZH1_MOUSE
NC score	0.012179 (rank : 211)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	156	Target Neighborhood Hits	126	Shared Neighborhood Hits	11
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_HUMAN
NC score	0.011623 (rank : 212)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	156	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

ADM1B_MOUSE
NC score	0.011272 (rank : 213)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	156	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

MIRO2_MOUSE
NC score	0.010527 (rank : 214)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	156	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZN7	Gene names	Rhot2, Arht2
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 2 (EC 3.6.5.-) (MIRO-2) (Ras homolog gene family member T2).

ECM2_HUMAN
NC score	0.008702 (rank : 215)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	156	Target Neighborhood Hits	402	Shared Neighborhood Hits	11
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

TIE2_HUMAN
NC score	0.002137 (rank : 216)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	156	Target Neighborhood Hits	1192	Shared Neighborhood Hits	24
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EGR4_HUMAN
NC score	-0.003847 (rank : 217)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	156	Target Neighborhood Hits	939	Shared Neighborhood Hits	3
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).