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Network neighborhood for query Sequence : IBP4_HUMAN

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IBP4_HUMAN
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IBP4_HUMAN
θ value	2.97304e-136 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	1.43246e-122 (rank : 2)	NC score	0.998415 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	50
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP5_HUMAN
θ value	1.12253e-42 (rank : 3)	NC score	0.928474 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	2.50074e-42 (rank : 4)	NC score	0.928886 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP1_MOUSE
θ value	8.89434e-40 (rank : 5)	NC score	0.918668 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	97	Shared Neighborhood Hits	40
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP2_HUMAN
θ value	2.19075e-38 (rank : 6)	NC score	0.926613 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	61	Shared Neighborhood Hits	45
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP2_MOUSE
θ value	7.79185e-36 (rank : 7)	NC score	0.926088 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	65	Shared Neighborhood Hits	46
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP3_HUMAN
θ value	3.61944e-33 (rank : 8)	NC score	0.914597 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP1_HUMAN
θ value	6.17384e-33 (rank : 9)	NC score	0.922501 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP3_MOUSE
θ value	7.80994e-28 (rank : 10)	NC score	0.911063 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP6_HUMAN
θ value	3.51386e-20 (rank : 11)	NC score	0.865540 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP6_MOUSE
θ value	7.32683e-18 (rank : 12)	NC score	0.855849 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	34
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

NID2_MOUSE
θ value	2.21117e-06 (rank : 13)	NC score	0.188595 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	338	Shared Neighborhood Hits	33
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NID2_HUMAN
θ value	4.92598e-06 (rank : 14)	NC score	0.188171 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	456	Shared Neighborhood Hits	34
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

HTRA1_HUMAN
θ value	1.09739e-05 (rank : 15)	NC score	0.299047 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	1.87187e-05 (rank : 16)	NC score	0.300563 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

SMOC2_HUMAN
θ value	0.000461057 (rank : 17)	NC score	0.380905 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

SMOC2_MOUSE
θ value	0.000461057 (rank : 18)	NC score	0.384020 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

TICN1_HUMAN
θ value	0.000602161 (rank : 19)	NC score	0.399759 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN1_MOUSE
θ value	0.000602161 (rank : 20)	NC score	0.401002 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	79	Shared Neighborhood Hits	40
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

ESM1_MOUSE
θ value	0.000786445 (rank : 21)	NC score	0.256631 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	107	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

NID1_HUMAN
θ value	0.00102713 (rank : 22)	NC score	0.177801 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
θ value	0.00102713 (rank : 23)	NC score	0.167278 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

TICN3_HUMAN
θ value	0.00134147 (rank : 24)	NC score	0.376572 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

CRIM1_HUMAN
θ value	0.00175202 (rank : 25)	NC score	0.139197 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	362	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

TICN3_MOUSE
θ value	0.00175202 (rank : 26)	NC score	0.370555 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	83	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

HG2A_MOUSE
θ value	0.00228821 (rank : 27)	NC score	0.402790 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	P04441, O19452	Gene names	Cd74, Ii
Domain Architecture
Description	H-2 class II histocompatibility antigen gamma chain (MHC class II- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD74 antigen).

SMOC1_HUMAN
θ value	0.00228821 (rank : 28)	NC score	0.363766 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

THYG_HUMAN
θ value	0.00228821 (rank : 29)	NC score	0.220118 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	154	Shared Neighborhood Hits	33
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

TICN2_MOUSE
θ value	0.00390308 (rank : 30)	NC score	0.390995 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

SMOC1_MOUSE
θ value	0.00665767 (rank : 31)	NC score	0.357429 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

TICN2_HUMAN
θ value	0.0113563 (rank : 32)	NC score	0.390104 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

CTGF_HUMAN
θ value	0.0252991 (rank : 33)	NC score	0.145418 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

HG2A_HUMAN
θ value	0.0252991 (rank : 34)	NC score	0.360652 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P04233, Q14597, Q29832, Q5U0J8, Q8WLP6	Gene names	CD74, DHLAG
Domain Architecture	No domain graphic available
Description	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD74 antigen).

KAZD1_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.195913 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

THYG_MOUSE
θ value	0.0431538 (rank : 36)	NC score	0.204977 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	161	Shared Neighborhood Hits	32
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

CYR61_HUMAN
θ value	0.0736092 (rank : 37)	NC score	0.134011 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	159	Shared Neighborhood Hits	23
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
θ value	0.0736092 (rank : 38)	NC score	0.133643 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

WISP2_HUMAN
θ value	0.125558 (rank : 39)	NC score	0.181182 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	126	Shared Neighborhood Hits	23
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

KAZD1_HUMAN
θ value	0.163984 (rank : 40)	NC score	0.188937 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

ATS2_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.009829 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

HDAC1_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.013872 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

FSTL3_MOUSE
θ value	1.38821 (rank : 43)	NC score	0.076277 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

HTRA3_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.165358 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA3_HUMAN
θ value	2.36792 (rank : 45)	NC score	0.167248 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

WISP2_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.146049 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	129	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

FBLI1_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.014306 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

TNR11_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.020051 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

FSTL3_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.075533 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

TACD2_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.212047 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	30
SwissProt Accessions	P09758, Q15658, Q96QD2	Gene names	TACSTD2, GA733-1, M1S1, TROP2
Domain Architecture
Description	Tumor-associated calcium signal transducer 2 precursor (Pancreatic carcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2).

TTF2_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.006245 (rank : 75)
Query Neighborhood Hits	52	Target Neighborhood Hits	364	Shared Neighborhood Hits	2
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TACD1_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.235436 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	31
SwissProt Accessions	P16422, P18180, Q96C47	Gene names	TACSTD1, GA733-2, M1S2, TROP1
Domain Architecture
Description	Tumor-associated calcium signal transducer 1 precursor (Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Adenocarcinoma- associated antigen) (KSA) (KS 1/4 antigen) (Cell surface glycoprotein Trop-1) (CD326 antigen).

CTGF_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.095311 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	124	Shared Neighborhood Hits	21
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

ESM1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.236777 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

FST_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.061852 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	129	Shared Neighborhood Hits	19
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

FST_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.059992 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	146	Shared Neighborhood Hits	19
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

HTRA2_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.068316 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.068540 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA4_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.126975 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	119	Shared Neighborhood Hits	22
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

IBP7_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.188493 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.186477 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	230	Shared Neighborhood Hits	25
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

LCE1B_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.061526 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.055901 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.054803 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1E_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.051800 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE2D_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.061962 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE4A_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.180573 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

NOV_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.123093 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	128	Shared Neighborhood Hits	21
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.109127 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	130	Shared Neighborhood Hits	18
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

SPRC_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.063194 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRC_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.061385 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRL1_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.055972 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

WISP1_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.077084 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

WISP1_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.072412 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP3_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.105538 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

Hits sorted by NC score

IBP4_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.97304e-136 (rank : 1)
Query Neighborhood Hits	52	Target Neighborhood Hits	52	Shared Neighborhood Hits	52
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
NC score	0.998415 (rank : 2)	θ value	1.43246e-122 (rank : 2)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	50
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP5_MOUSE
NC score	0.928886 (rank : 3)	θ value	2.50074e-42 (rank : 4)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_HUMAN
NC score	0.928474 (rank : 4)	θ value	1.12253e-42 (rank : 3)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP2_HUMAN
NC score	0.926613 (rank : 5)	θ value	2.19075e-38 (rank : 6)
Query Neighborhood Hits	52	Target Neighborhood Hits	61	Shared Neighborhood Hits	45
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP2_MOUSE
NC score	0.926088 (rank : 6)	θ value	7.79185e-36 (rank : 7)
Query Neighborhood Hits	52	Target Neighborhood Hits	65	Shared Neighborhood Hits	46
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP1_HUMAN
NC score	0.922501 (rank : 7)	θ value	6.17384e-33 (rank : 9)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP1_MOUSE
NC score	0.918668 (rank : 8)	θ value	8.89434e-40 (rank : 5)
Query Neighborhood Hits	52	Target Neighborhood Hits	97	Shared Neighborhood Hits	40
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP3_HUMAN
NC score	0.914597 (rank : 9)	θ value	3.61944e-33 (rank : 8)
Query Neighborhood Hits	52	Target Neighborhood Hits	67	Shared Neighborhood Hits	45
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP3_MOUSE
NC score	0.911063 (rank : 10)	θ value	7.80994e-28 (rank : 10)
Query Neighborhood Hits	52	Target Neighborhood Hits	60	Shared Neighborhood Hits	45
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP6_HUMAN
NC score	0.865540 (rank : 11)	θ value	3.51386e-20 (rank : 11)
Query Neighborhood Hits	52	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP6_MOUSE
NC score	0.855849 (rank : 12)	θ value	7.32683e-18 (rank : 12)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	34
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

HG2A_MOUSE
NC score	0.402790 (rank : 13)	θ value	0.00228821 (rank : 27)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	P04441, O19452	Gene names	Cd74, Ii
Domain Architecture
Description	H-2 class II histocompatibility antigen gamma chain (MHC class II- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD74 antigen).

TICN1_MOUSE
NC score	0.401002 (rank : 14)	θ value	0.000602161 (rank : 20)
Query Neighborhood Hits	52	Target Neighborhood Hits	79	Shared Neighborhood Hits	40
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN1_HUMAN
NC score	0.399759 (rank : 15)	θ value	0.000602161 (rank : 19)
Query Neighborhood Hits	52	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN2_MOUSE
NC score	0.390995 (rank : 16)	θ value	0.00390308 (rank : 30)
Query Neighborhood Hits	52	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TICN2_HUMAN
NC score	0.390104 (rank : 17)	θ value	0.0113563 (rank : 32)
Query Neighborhood Hits	52	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

SMOC2_MOUSE
NC score	0.384020 (rank : 18)	θ value	0.000461057 (rank : 18)
Query Neighborhood Hits	52	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

SMOC2_HUMAN
NC score	0.380905 (rank : 19)	θ value	0.000461057 (rank : 17)
Query Neighborhood Hits	52	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

TICN3_HUMAN
NC score	0.376572 (rank : 20)	θ value	0.00134147 (rank : 24)
Query Neighborhood Hits	52	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

TICN3_MOUSE
NC score	0.370555 (rank : 21)	θ value	0.00175202 (rank : 26)
Query Neighborhood Hits	52	Target Neighborhood Hits	83	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

SMOC1_HUMAN
NC score	0.363766 (rank : 22)	θ value	0.00228821 (rank : 28)
Query Neighborhood Hits	52	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

HG2A_HUMAN
NC score	0.360652 (rank : 23)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	52	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P04233, Q14597, Q29832, Q5U0J8, Q8WLP6	Gene names	CD74, DHLAG
Domain Architecture	No domain graphic available
Description	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD74 antigen).

SMOC1_MOUSE
NC score	0.357429 (rank : 24)	θ value	0.00665767 (rank : 31)
Query Neighborhood Hits	52	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

HTRA1_MOUSE
NC score	0.300563 (rank : 25)	θ value	1.87187e-05 (rank : 16)
Query Neighborhood Hits	52	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA1_HUMAN
NC score	0.299047 (rank : 26)	θ value	1.09739e-05 (rank : 15)
Query Neighborhood Hits	52	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

ESM1_MOUSE
NC score	0.256631 (rank : 27)	θ value	0.000786445 (rank : 21)
Query Neighborhood Hits	52	Target Neighborhood Hits	107	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_HUMAN
NC score	0.236777 (rank : 28)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	52	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

TACD1_HUMAN
NC score	0.235436 (rank : 29)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	52	Target Neighborhood Hits	34	Shared Neighborhood Hits	31
SwissProt Accessions	P16422, P18180, Q96C47	Gene names	TACSTD1, GA733-2, M1S2, TROP1
Domain Architecture
Description	Tumor-associated calcium signal transducer 1 precursor (Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Adenocarcinoma- associated antigen) (KSA) (KS 1/4 antigen) (Cell surface glycoprotein Trop-1) (CD326 antigen).

THYG_HUMAN
NC score	0.220118 (rank : 30)	θ value	0.00228821 (rank : 29)
Query Neighborhood Hits	52	Target Neighborhood Hits	154	Shared Neighborhood Hits	33
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

TACD2_HUMAN
NC score	0.212047 (rank : 31)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	52	Target Neighborhood Hits	41	Shared Neighborhood Hits	30
SwissProt Accessions	P09758, Q15658, Q96QD2	Gene names	TACSTD2, GA733-1, M1S1, TROP2
Domain Architecture
Description	Tumor-associated calcium signal transducer 2 precursor (Pancreatic carcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2).

THYG_MOUSE
NC score	0.204977 (rank : 32)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	52	Target Neighborhood Hits	161	Shared Neighborhood Hits	32
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

KAZD1_MOUSE
NC score	0.195913 (rank : 33)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	52	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KAZD1_HUMAN
NC score	0.188937 (rank : 34)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	52	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NID2_MOUSE
NC score	0.188595 (rank : 35)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	52	Target Neighborhood Hits	338	Shared Neighborhood Hits	33
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

IBP7_HUMAN
NC score	0.188493 (rank : 36)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	52	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

NID2_HUMAN
NC score	0.188171 (rank : 37)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	52	Target Neighborhood Hits	456	Shared Neighborhood Hits	34
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

IBP7_MOUSE
NC score	0.186477 (rank : 38)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	52	Target Neighborhood Hits	230	Shared Neighborhood Hits	25
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

WISP2_HUMAN
NC score	0.181182 (rank : 39)	θ value	0.125558 (rank : 39)
Query Neighborhood Hits	52	Target Neighborhood Hits	126	Shared Neighborhood Hits	23
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

LCE4A_HUMAN
NC score	0.180573 (rank : 40)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	52	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

NID1_HUMAN
NC score	0.177801 (rank : 41)	θ value	0.00102713 (rank : 22)
Query Neighborhood Hits	52	Target Neighborhood Hits	329	Shared Neighborhood Hits	32
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
NC score	0.167278 (rank : 42)	θ value	0.00102713 (rank : 23)
Query Neighborhood Hits	52	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

HTRA3_HUMAN
NC score	0.167248 (rank : 43)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	52	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
NC score	0.165358 (rank : 44)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	52	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

WISP2_MOUSE
NC score	0.146049 (rank : 45)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	52	Target Neighborhood Hits	129	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

CTGF_HUMAN
NC score	0.145418 (rank : 46)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	52	Target Neighborhood Hits	128	Shared Neighborhood Hits	23
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CRIM1_HUMAN
NC score	0.139197 (rank : 47)	θ value	0.00175202 (rank : 25)
Query Neighborhood Hits	52	Target Neighborhood Hits	362	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CYR61_HUMAN
NC score	0.134011 (rank : 48)	θ value	0.0736092 (rank : 37)
Query Neighborhood Hits	52	Target Neighborhood Hits	159	Shared Neighborhood Hits	23
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
NC score	0.133643 (rank : 49)	θ value	0.0736092 (rank : 38)
Query Neighborhood Hits	52	Target Neighborhood Hits	156	Shared Neighborhood Hits	22
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

HTRA4_HUMAN
NC score	0.126975 (rank : 50)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	52	Target Neighborhood Hits	119	Shared Neighborhood Hits	22
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

NOV_HUMAN
NC score	0.123093 (rank : 51)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	52	Target Neighborhood Hits	128	Shared Neighborhood Hits	21
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
NC score	0.109127 (rank : 52)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	52	Target Neighborhood Hits	130	Shared Neighborhood Hits	18
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP3_HUMAN
NC score	0.105538 (rank : 53)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	52	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

CTGF_MOUSE
NC score	0.095311 (rank : 54)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	52	Target Neighborhood Hits	124	Shared Neighborhood Hits	21
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

WISP1_HUMAN
NC score	0.077084 (rank : 55)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	52	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

FSTL3_MOUSE
NC score	0.076277 (rank : 56)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	52	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FSTL3_HUMAN
NC score	0.075533 (rank : 57)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	52	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

WISP1_MOUSE
NC score	0.072412 (rank : 58)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	52	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

HTRA2_MOUSE
NC score	0.068540 (rank : 59)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	52	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
NC score	0.068316 (rank : 60)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	52	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

SPRC_HUMAN
NC score	0.063194 (rank : 61)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	52	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

LCE2D_HUMAN
NC score	0.061962 (rank : 62)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	52	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

FST_HUMAN
NC score	0.061852 (rank : 63)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	52	Target Neighborhood Hits	129	Shared Neighborhood Hits	19
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

LCE1B_HUMAN
NC score	0.061526 (rank : 64)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	52	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

SPRC_MOUSE
NC score	0.061385 (rank : 65)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	52	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

FST_MOUSE
NC score	0.059992 (rank : 66)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	52	Target Neighborhood Hits	146	Shared Neighborhood Hits	19
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

SPRL1_HUMAN
NC score	0.055972 (rank : 67)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	52	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

LCE1C_HUMAN
NC score	0.055901 (rank : 68)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	52	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
NC score	0.054803 (rank : 69)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	52	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1E_HUMAN
NC score	0.051800 (rank : 70)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	52	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

TNR11_HUMAN
NC score	0.020051 (rank : 71)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	52	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

FBLI1_HUMAN
NC score	0.014306 (rank : 72)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	52	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

HDAC1_HUMAN
NC score	0.013872 (rank : 73)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	52	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

ATS2_HUMAN
NC score	0.009829 (rank : 74)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	52	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

TTF2_MOUSE
NC score	0.006245 (rank : 75)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	52	Target Neighborhood Hits	364	Shared Neighborhood Hits	2
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).