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Network neighborhood for query Sequence : WISP1_MOUSE

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WISP1_MOUSE
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

WISP1_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	123
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
θ value	4.84403e-179 (rank : 2)	NC score	0.991762 (rank : 2)
Query Neighborhood Hits	123	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

CTGF_HUMAN
θ value	3.22093e-90 (rank : 3)	NC score	0.956054 (rank : 5)
Query Neighborhood Hits	123	Target Neighborhood Hits	128	Shared Neighborhood Hits	85
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CTGF_MOUSE
θ value	1.31072e-83 (rank : 4)	NC score	0.958570 (rank : 3)
Query Neighborhood Hits	123	Target Neighborhood Hits	124	Shared Neighborhood Hits	87
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

WISP3_HUMAN
θ value	1.14825e-79 (rank : 5)	NC score	0.956399 (rank : 4)
Query Neighborhood Hits	123	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

CYR61_MOUSE
θ value	5.51964e-74 (rank : 6)	NC score	0.946402 (rank : 9)
Query Neighborhood Hits	123	Target Neighborhood Hits	156	Shared Neighborhood Hits	92
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CYR61_HUMAN
θ value	1.22964e-73 (rank : 7)	NC score	0.948317 (rank : 8)
Query Neighborhood Hits	123	Target Neighborhood Hits	159	Shared Neighborhood Hits	96
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

NOV_HUMAN
θ value	2.31901e-72 (rank : 8)	NC score	0.950088 (rank : 7)
Query Neighborhood Hits	123	Target Neighborhood Hits	128	Shared Neighborhood Hits	84
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
θ value	3.34864e-71 (rank : 9)	NC score	0.950594 (rank : 6)
Query Neighborhood Hits	123	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP2_MOUSE
θ value	3.98324e-48 (rank : 10)	NC score	0.920769 (rank : 11)
Query Neighborhood Hits	123	Target Neighborhood Hits	129	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP2_HUMAN
θ value	2.04573e-44 (rank : 11)	NC score	0.922091 (rank : 10)
Query Neighborhood Hits	123	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

BMPER_HUMAN
θ value	4.45536e-07 (rank : 12)	NC score	0.330394 (rank : 13)
Query Neighborhood Hits	123	Target Neighborhood Hits	175	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

BMPER_MOUSE
θ value	2.88788e-06 (rank : 13)	NC score	0.335731 (rank : 12)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

SSPO_MOUSE
θ value	1.43324e-05 (rank : 14)	NC score	0.241308 (rank : 21)
Query Neighborhood Hits	123	Target Neighborhood Hits	800	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

MUC5B_HUMAN
θ value	0.000121331 (rank : 15)	NC score	0.202155 (rank : 27)
Query Neighborhood Hits	123	Target Neighborhood Hits	1020	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CRDL2_MOUSE
θ value	0.000158464 (rank : 16)	NC score	0.279529 (rank : 17)
Query Neighborhood Hits	123	Target Neighborhood Hits	81	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

CRIM1_HUMAN
θ value	0.00020696 (rank : 17)	NC score	0.293833 (rank : 15)
Query Neighborhood Hits	123	Target Neighborhood Hits	362	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

FRAS1_MOUSE
θ value	0.000786445 (rank : 18)	NC score	0.187464 (rank : 28)
Query Neighborhood Hits	123	Target Neighborhood Hits	747	Shared Neighborhood Hits	97
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

JAG1_MOUSE
θ value	0.00102713 (rank : 19)	NC score	0.079604 (rank : 129)
Query Neighborhood Hits	123	Target Neighborhood Hits	518	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

FRAS1_HUMAN
θ value	0.00175202 (rank : 20)	NC score	0.185030 (rank : 30)
Query Neighborhood Hits	123	Target Neighborhood Hits	759	Shared Neighborhood Hits	94
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NELL2_MOUSE
θ value	0.00175202 (rank : 21)	NC score	0.156342 (rank : 43)
Query Neighborhood Hits	123	Target Neighborhood Hits	436	Shared Neighborhood Hits	61
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

TSP1_HUMAN
θ value	0.00509761 (rank : 22)	NC score	0.209431 (rank : 25)
Query Neighborhood Hits	123	Target Neighborhood Hits	389	Shared Neighborhood Hits	101
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

NELL2_HUMAN
θ value	0.00665767 (rank : 23)	NC score	0.155713 (rank : 44)
Query Neighborhood Hits	123	Target Neighborhood Hits	449	Shared Neighborhood Hits	61
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

TSP1_MOUSE
θ value	0.00665767 (rank : 24)	NC score	0.206161 (rank : 26)
Query Neighborhood Hits	123	Target Neighborhood Hits	396	Shared Neighborhood Hits	101
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_HUMAN
θ value	0.00665767 (rank : 25)	NC score	0.185304 (rank : 29)
Query Neighborhood Hits	123	Target Neighborhood Hits	359	Shared Neighborhood Hits	99
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATS19_MOUSE
θ value	0.0148317 (rank : 26)	NC score	0.152707 (rank : 45)
Query Neighborhood Hits	123	Target Neighborhood Hits	188	Shared Neighborhood Hits	58
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

SLIT2_HUMAN
θ value	0.0148317 (rank : 27)	NC score	0.075444 (rank : 134)
Query Neighborhood Hits	123	Target Neighborhood Hits	708	Shared Neighborhood Hits	49
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	0.0148317 (rank : 28)	NC score	0.074073 (rank : 137)
Query Neighborhood Hits	123	Target Neighborhood Hits	684	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

CRDL1_MOUSE
θ value	0.0193708 (rank : 29)	NC score	0.269388 (rank : 18)
Query Neighborhood Hits	123	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

ATS19_HUMAN
θ value	0.0252991 (rank : 30)	NC score	0.150591 (rank : 49)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS12_MOUSE
θ value	0.0330416 (rank : 31)	NC score	0.147544 (rank : 52)
Query Neighborhood Hits	123	Target Neighborhood Hits	220	Shared Neighborhood Hits	58
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

BAI1_HUMAN
θ value	0.0330416 (rank : 32)	NC score	0.131589 (rank : 71)
Query Neighborhood Hits	123	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	0.0330416 (rank : 33)	NC score	0.134833 (rank : 66)
Query Neighborhood Hits	123	Target Neighborhood Hits	340	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

TSP2_MOUSE
θ value	0.0330416 (rank : 34)	NC score	0.181900 (rank : 35)
Query Neighborhood Hits	123	Target Neighborhood Hits	352	Shared Neighborhood Hits	93
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

CO1A1_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.098027 (rank : 111)
Query Neighborhood Hits	123	Target Neighborhood Hits	457	Shared Neighborhood Hits	42
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CRDL1_HUMAN
θ value	0.0431538 (rank : 36)	NC score	0.262373 (rank : 20)
Query Neighborhood Hits	123	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

JAG1_HUMAN
θ value	0.0563607 (rank : 37)	NC score	0.079435 (rank : 130)
Query Neighborhood Hits	123	Target Neighborhood Hits	514	Shared Neighborhood Hits	59
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

NELL1_HUMAN
θ value	0.0563607 (rank : 38)	NC score	0.166357 (rank : 41)
Query Neighborhood Hits	123	Target Neighborhood Hits	451	Shared Neighborhood Hits	63
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

ZAN_MOUSE
θ value	0.0563607 (rank : 39)	NC score	0.174840 (rank : 40)
Query Neighborhood Hits	123	Target Neighborhood Hits	808	Shared Neighborhood Hits	81
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ATL2_HUMAN
θ value	0.0736092 (rank : 40)	NC score	0.182000 (rank : 34)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	61
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL2_MOUSE
θ value	0.0736092 (rank : 41)	NC score	0.180499 (rank : 38)
Query Neighborhood Hits	123	Target Neighborhood Hits	137	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATS9_HUMAN
θ value	0.0736092 (rank : 42)	NC score	0.150983 (rank : 48)
Query Neighborhood Hits	123	Target Neighborhood Hits	219	Shared Neighborhood Hits	65
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

IBP7_HUMAN
θ value	0.0736092 (rank : 43)	NC score	0.143350 (rank : 54)
Query Neighborhood Hits	123	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

ATS15_HUMAN
θ value	0.0961366 (rank : 44)	NC score	0.134764 (rank : 67)
Query Neighborhood Hits	123	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS12_HUMAN
θ value	0.125558 (rank : 45)	NC score	0.152479 (rank : 46)
Query Neighborhood Hits	123	Target Neighborhood Hits	251	Shared Neighborhood Hits	61
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS16_MOUSE
θ value	0.125558 (rank : 46)	NC score	0.140388 (rank : 58)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS18_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.136309 (rank : 64)
Query Neighborhood Hits	123	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

BAI3_HUMAN
θ value	0.125558 (rank : 48)	NC score	0.124176 (rank : 82)
Query Neighborhood Hits	123	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
θ value	0.125558 (rank : 49)	NC score	0.127569 (rank : 75)
Query Neighborhood Hits	123	Target Neighborhood Hits	250	Shared Neighborhood Hits	55
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

HTRA4_HUMAN
θ value	0.125558 (rank : 50)	NC score	0.214495 (rank : 22)
Query Neighborhood Hits	123	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

VWF_MOUSE
θ value	0.125558 (rank : 51)	NC score	0.184751 (rank : 32)
Query Neighborhood Hits	123	Target Neighborhood Hits	381	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

HTRA3_HUMAN
θ value	0.163984 (rank : 52)	NC score	0.180543 (rank : 37)
Query Neighborhood Hits	123	Target Neighborhood Hits	152	Shared Neighborhood Hits	35
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	0.163984 (rank : 53)	NC score	0.181300 (rank : 36)
Query Neighborhood Hits	123	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

IBP7_MOUSE
θ value	0.163984 (rank : 54)	NC score	0.158733 (rank : 42)
Query Neighborhood Hits	123	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

SPON1_HUMAN
θ value	0.163984 (rank : 55)	NC score	0.211249 (rank : 23)
Query Neighborhood Hits	123	Target Neighborhood Hits	117	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
θ value	0.163984 (rank : 56)	NC score	0.209599 (rank : 24)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

ATS1_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.151301 (rank : 47)
Query Neighborhood Hits	123	Target Neighborhood Hits	158	Shared Neighborhood Hits	58
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS3_HUMAN
θ value	0.21417 (rank : 58)	NC score	0.132796 (rank : 69)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

GRN_HUMAN
θ value	0.21417 (rank : 59)	NC score	0.094193 (rank : 112)
Query Neighborhood Hits	123	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

ZAN_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.149480 (rank : 51)
Query Neighborhood Hits	123	Target Neighborhood Hits	679	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ATS20_HUMAN
θ value	0.279714 (rank : 61)	NC score	0.137350 (rank : 63)
Query Neighborhood Hits	123	Target Neighborhood Hits	192	Shared Neighborhood Hits	65
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS20_MOUSE
θ value	0.279714 (rank : 62)	NC score	0.147112 (rank : 53)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

CRDL2_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.289101 (rank : 16)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

KR104_HUMAN
θ value	0.365318 (rank : 64)	NC score	0.127837 (rank : 74)
Query Neighborhood Hits	123	Target Neighborhood Hits	313	Shared Neighborhood Hits	63
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

ESM1_MOUSE
θ value	0.47712 (rank : 65)	NC score	0.298863 (rank : 14)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

HTRA1_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.184883 (rank : 31)
Query Neighborhood Hits	123	Target Neighborhood Hits	155	Shared Neighborhood Hits	34
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

MUC2_HUMAN
θ value	0.47712 (rank : 67)	NC score	0.143258 (rank : 55)
Query Neighborhood Hits	123	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ATS16_HUMAN
θ value	0.62314 (rank : 68)	NC score	0.139033 (rank : 62)
Query Neighborhood Hits	123	Target Neighborhood Hits	208	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ESM1_HUMAN
θ value	0.62314 (rank : 69)	NC score	0.266023 (rank : 19)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

IBP2_MOUSE
θ value	0.62314 (rank : 70)	NC score	0.150386 (rank : 50)
Query Neighborhood Hits	123	Target Neighborhood Hits	65	Shared Neighborhood Hits	26
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

SEM5A_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.107981 (rank : 99)
Query Neighborhood Hits	123	Target Neighborhood Hits	162	Shared Neighborhood Hits	59
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

TECTA_MOUSE
θ value	0.62314 (rank : 72)	NC score	0.114377 (rank : 90)
Query Neighborhood Hits	123	Target Neighborhood Hits	244	Shared Neighborhood Hits	42
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

ATS18_MOUSE
θ value	0.813845 (rank : 73)	NC score	0.140044 (rank : 59)
Query Neighborhood Hits	123	Target Neighborhood Hits	163	Shared Neighborhood Hits	58
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

NOTC4_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.064537 (rank : 155)
Query Neighborhood Hits	123	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_MOUSE
θ value	0.813845 (rank : 75)	NC score	0.064799 (rank : 153)
Query Neighborhood Hits	123	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

SEM5A_HUMAN
θ value	0.813845 (rank : 76)	NC score	0.111408 (rank : 94)
Query Neighborhood Hits	123	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ATL3_HUMAN
θ value	1.06291 (rank : 77)	NC score	0.139812 (rank : 60)
Query Neighborhood Hits	123	Target Neighborhood Hits	414	Shared Neighborhood Hits	66
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATS1_HUMAN
θ value	1.06291 (rank : 78)	NC score	0.141048 (rank : 56)
Query Neighborhood Hits	123	Target Neighborhood Hits	159	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

MCSP_MOUSE
θ value	1.06291 (rank : 79)	NC score	0.106840 (rank : 101)
Query Neighborhood Hits	123	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

RECK_HUMAN
θ value	1.06291 (rank : 80)	NC score	0.100759 (rank : 108)
Query Neighborhood Hits	123	Target Neighborhood Hits	189	Shared Neighborhood Hits	47
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

ATL5_HUMAN
θ value	1.38821 (rank : 81)	NC score	0.139301 (rank : 61)
Query Neighborhood Hits	123	Target Neighborhood Hits	103	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

BAI2_HUMAN
θ value	1.38821 (rank : 82)	NC score	0.124950 (rank : 81)
Query Neighborhood Hits	123	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	1.38821 (rank : 83)	NC score	0.125523 (rank : 80)
Query Neighborhood Hits	123	Target Neighborhood Hits	323	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

CILP1_MOUSE
θ value	1.38821 (rank : 84)	NC score	0.079851 (rank : 128)
Query Neighborhood Hits	123	Target Neighborhood Hits	282	Shared Neighborhood Hits	50
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

HTRA1_MOUSE
θ value	1.38821 (rank : 85)	NC score	0.176329 (rank : 39)
Query Neighborhood Hits	123	Target Neighborhood Hits	140	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

TNR8_HUMAN
θ value	1.38821 (rank : 86)	NC score	0.036028 (rank : 226)
Query Neighborhood Hits	123	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

AGRIN_HUMAN
θ value	1.81305 (rank : 87)	NC score	0.067783 (rank : 151)
Query Neighborhood Hits	123	Target Neighborhood Hits	582	Shared Neighborhood Hits	59
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ATS13_HUMAN
θ value	1.81305 (rank : 88)	NC score	0.126695 (rank : 77)
Query Neighborhood Hits	123	Target Neighborhood Hits	238	Shared Neighborhood Hits	52
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS17_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.140707 (rank : 57)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

RECK_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.099712 (rank : 109)
Query Neighborhood Hits	123	Target Neighborhood Hits	158	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

HMCN1_HUMAN
θ value	2.36792 (rank : 91)	NC score	0.091938 (rank : 116)
Query Neighborhood Hits	123	Target Neighborhood Hits	983	Shared Neighborhood Hits	91
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

PAPPA_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.030957 (rank : 229)
Query Neighborhood Hits	123	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

CHRD_MOUSE
θ value	3.0926 (rank : 93)	NC score	0.118436 (rank : 88)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

CILP1_HUMAN
θ value	3.0926 (rank : 94)	NC score	0.071166 (rank : 146)
Query Neighborhood Hits	123	Target Neighborhood Hits	266	Shared Neighborhood Hits	48
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FBN3_HUMAN
θ value	3.0926 (rank : 95)	NC score	0.058886 (rank : 174)
Query Neighborhood Hits	123	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

GRN_MOUSE
θ value	3.0926 (rank : 96)	NC score	0.108740 (rank : 96)
Query Neighborhood Hits	123	Target Neighborhood Hits	248	Shared Neighborhood Hits	45
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

IBP5_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.119320 (rank : 87)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	3.0926 (rank : 98)	NC score	0.121138 (rank : 84)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

SLIT1_MOUSE
θ value	3.0926 (rank : 99)	NC score	0.051929 (rank : 217)
Query Neighborhood Hits	123	Target Neighborhood Hits	715	Shared Neighborhood Hits	45
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

THSD1_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.102291 (rank : 106)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

VWF_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.184504 (rank : 33)
Query Neighborhood Hits	123	Target Neighborhood Hits	396	Shared Neighborhood Hits	75
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ECM2_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.045167 (rank : 225)
Query Neighborhood Hits	123	Target Neighborhood Hits	402	Shared Neighborhood Hits	39
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

IBP3_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.082154 (rank : 126)
Query Neighborhood Hits	123	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

PAPPA_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.024547 (rank : 230)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

SEM5B_MOUSE
θ value	4.03905 (rank : 105)	NC score	0.098045 (rank : 110)
Query Neighborhood Hits	123	Target Neighborhood Hits	190	Shared Neighborhood Hits	57
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

TECTA_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.110193 (rank : 95)
Query Neighborhood Hits	123	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

TRBM_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.069542 (rank : 147)
Query Neighborhood Hits	123	Target Neighborhood Hits	339	Shared Neighborhood Hits	46
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

ATS2_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.120396 (rank : 86)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

CO1A1_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.060272 (rank : 166)
Query Neighborhood Hits	123	Target Neighborhood Hits	475	Shared Neighborhood Hits	34
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

MATN3_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.035728 (rank : 227)
Query Neighborhood Hits	123	Target Neighborhood Hits	261	Shared Neighborhood Hits	34
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

MEGF6_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.086011 (rank : 121)
Query Neighborhood Hits	123	Target Neighborhood Hits	671	Shared Neighborhood Hits	78
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

SLIT1_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.055029 (rank : 199)
Query Neighborhood Hits	123	Target Neighborhood Hits	700	Shared Neighborhood Hits	45
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

THSD1_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.103177 (rank : 105)
Query Neighborhood Hits	123	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TINAG_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.032812 (rank : 228)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

CO2A1_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.062181 (rank : 161)
Query Neighborhood Hits	123	Target Neighborhood Hits	483	Shared Neighborhood Hits	33
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

IBP1_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.089415 (rank : 119)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	30
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

SEM5B_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.094079 (rank : 113)
Query Neighborhood Hits	123	Target Neighborhood Hits	178	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SLIT3_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.051978 (rank : 216)
Query Neighborhood Hits	123	Target Neighborhood Hits	700	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

CO5A2_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.056807 (rank : 190)
Query Neighborhood Hits	123	Target Neighborhood Hits	760	Shared Neighborhood Hits	44
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

IBP2_HUMAN
θ value	8.99809 (rank : 120)	NC score	0.130400 (rank : 72)
Query Neighborhood Hits	123	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

SOSD1_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.056935 (rank : 187)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X4U4, Q96HJ7, Q9Y3U3	Gene names	SOSTDC1, USAG1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1).

SOSD1_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.055428 (rank : 197)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQN4, Q8CF09	Gene names	Sostdc1, Sostl, Usag1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) (Sclerostin-like protein).

SREC2_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.052087 (rank : 215)
Query Neighborhood Hits	123	Target Neighborhood Hits	645	Shared Neighborhood Hits	49
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

ATL1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.133293 (rank : 68)
Query Neighborhood Hits	123	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.112337 (rank : 93)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATS13_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.122912 (rank : 83)
Query Neighborhood Hits	123	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS14_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.128084 (rank : 73)
Query Neighborhood Hits	123	Target Neighborhood Hits	382	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.126868 (rank : 76)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS4_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.108290 (rank : 98)
Query Neighborhood Hits	123	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS4_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.108689 (rank : 97)
Query Neighborhood Hits	123	Target Neighborhood Hits	145	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS5_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.102205 (rank : 107)
Query Neighborhood Hits	123	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.107355 (rank : 100)
Query Neighborhood Hits	123	Target Neighborhood Hits	147	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS6_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.120593 (rank : 85)
Query Neighborhood Hits	123	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS7_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.125859 (rank : 79)
Query Neighborhood Hits	123	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS8_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.112383 (rank : 92)
Query Neighborhood Hits	123	Target Neighborhood Hits	145	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS8_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.114324 (rank : 91)
Query Neighborhood Hits	123	Target Neighborhood Hits	139	Shared Neighborhood Hits	50
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

CHRD_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.126497 (rank : 78)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

CI094_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.115781 (rank : 89)
Query Neighborhood Hits	123	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CILP2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.082301 (rank : 125)
Query Neighborhood Hits	123	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CO6_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.086139 (rank : 120)
Query Neighborhood Hits	123	Target Neighborhood Hits	331	Shared Neighborhood Hits	62
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO7_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.056978 (rank : 186)
Query Neighborhood Hits	123	Target Neighborhood Hits	278	Shared Neighborhood Hits	53
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CO8A_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.059247 (rank : 172)
Query Neighborhood Hits	123	Target Neighborhood Hits	200	Shared Neighborhood Hits	48
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8A_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.058453 (rank : 178)
Query Neighborhood Hits	123	Target Neighborhood Hits	182	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8B_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.059992 (rank : 168)
Query Neighborhood Hits	123	Target Neighborhood Hits	199	Shared Neighborhood Hits	42
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CO8B_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.063525 (rank : 157)
Query Neighborhood Hits	123	Target Neighborhood Hits	224	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

COMP_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.057556 (rank : 182)
Query Neighborhood Hits	123	Target Neighborhood Hits	258	Shared Neighborhood Hits	29
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

COMP_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.061140 (rank : 163)
Query Neighborhood Hits	123	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

DLK_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.059595 (rank : 171)
Query Neighborhood Hits	123	Target Neighborhood Hits	374	Shared Neighborhood Hits	42
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DLL1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.052417 (rank : 213)
Query Neighborhood Hits	123	Target Neighborhood Hits	456	Shared Neighborhood Hits	43
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

DLL3_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.051155 (rank : 219)
Query Neighborhood Hits	123	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

DLL4_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.050329 (rank : 224)
Query Neighborhood Hits	123	Target Neighborhood Hits	440	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

EGFL9_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.053892 (rank : 208)
Query Neighborhood Hits	123	Target Neighborhood Hits	379	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

FBLN1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.053173 (rank : 211)
Query Neighborhood Hits	123	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.051530 (rank : 218)
Query Neighborhood Hits	123	Target Neighborhood Hits	505	Shared Neighborhood Hits	53
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBN1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.058524 (rank : 177)
Query Neighborhood Hits	123	Target Neighborhood Hits	557	Shared Neighborhood Hits	53
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.055713 (rank : 196)
Query Neighborhood Hits	123	Target Neighborhood Hits	563	Shared Neighborhood Hits	52
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN2_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.060253 (rank : 167)
Query Neighborhood Hits	123	Target Neighborhood Hits	560	Shared Neighborhood Hits	53
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.058883 (rank : 175)
Query Neighborhood Hits	123	Target Neighborhood Hits	549	Shared Neighborhood Hits	53
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

IBP1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.092298 (rank : 115)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP3_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.091128 (rank : 117)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP4_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.072412 (rank : 143)
Query Neighborhood Hits	123	Target Neighborhood Hits	52	Shared Neighborhood Hits	18
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.077687 (rank : 131)
Query Neighborhood Hits	123	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

JAG2_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.063139 (rank : 158)
Query Neighborhood Hits	123	Target Neighborhood Hits	491	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.062117 (rank : 162)
Query Neighborhood Hits	123	Target Neighborhood Hits	504	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KAZD1_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.106240 (rank : 102)
Query Neighborhood Hits	123	Target Neighborhood Hits	248	Shared Neighborhood Hits	32
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.104231 (rank : 104)
Query Neighborhood Hits	123	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KR101_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.082393 (rank : 124)
Query Neighborhood Hits	123	Target Neighborhood Hits	261	Shared Neighborhood Hits	56
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR102_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.071712 (rank : 144)
Query Neighborhood Hits	123	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

KR103_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.054372 (rank : 203)
Query Neighborhood Hits	123	Target Neighborhood Hits	212	Shared Neighborhood Hits	43
SwissProt Accessions	P60369, Q70LJ4	Gene names	KRTAP10-3, KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-3 (Keratin-associated protein 10.3) (High sulfur keratin-associated protein 10.3) (Keratin-associated protein 18-3) (Keratin-associated protein 18.3).

KR105_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.074423 (rank : 136)
Query Neighborhood Hits	123	Target Neighborhood Hits	271	Shared Neighborhood Hits	54
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR106_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.093107 (rank : 114)
Query Neighborhood Hits	123	Target Neighborhood Hits	347	Shared Neighborhood Hits	63
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.104942 (rank : 103)
Query Neighborhood Hits	123	Target Neighborhood Hits	330	Shared Neighborhood Hits	57
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR108_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.081834 (rank : 127)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	48
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

KR109_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.074875 (rank : 135)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	49
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR10A_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.055125 (rank : 198)
Query Neighborhood Hits	123	Target Neighborhood Hits	232	Shared Neighborhood Hits	46
SwissProt Accessions	P60014	Gene names	KRTAP10-10, KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-10 (Keratin-associated protein 10.10) (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10).

KR10B_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.067613 (rank : 152)
Query Neighborhood Hits	123	Target Neighborhood Hits	269	Shared Neighborhood Hits	49
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KR10C_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.073027 (rank : 140)
Query Neighborhood Hits	123	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KR412_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.057739 (rank : 180)
Query Neighborhood Hits	123	Target Neighborhood Hits	178	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

KR414_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.059676 (rank : 170)
Query Neighborhood Hits	123	Target Neighborhood Hits	199	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ6	Gene names	KRTAP4-14, KAP4.14, KRTAP4.14
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-14 (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14).

KRA13_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.050346 (rank : 223)
Query Neighborhood Hits	123	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IUG1, Q07628, Q8IUG0, Q9BYS2	Gene names	KRTAP1-3, B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9).

KRA45_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.056872 (rank : 189)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

KRA47_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.064636 (rank : 154)
Query Neighborhood Hits	123	Target Neighborhood Hits	204	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

KRA51_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.054629 (rank : 201)
Query Neighborhood Hits	123	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA53_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.060586 (rank : 165)
Query Neighborhood Hits	123	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA57_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.050355 (rank : 222)
Query Neighborhood Hits	123	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.083370 (rank : 123)
Query Neighborhood Hits	123	Target Neighborhood Hits	324	Shared Neighborhood Hits	43
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.076359 (rank : 132)
Query Neighborhood Hits	123	Target Neighborhood Hits	310	Shared Neighborhood Hits	41
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA92_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.060795 (rank : 164)
Query Neighborhood Hits	123	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.054058 (rank : 207)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

KRA98_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.054145 (rank : 205)
Query Neighborhood Hits	123	Target Neighborhood Hits	185	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

LCE1A_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.058911 (rank : 173)
Query Neighborhood Hits	123	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1B_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.055004 (rank : 200)
Query Neighborhood Hits	123	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.062459 (rank : 160)
Query Neighborhood Hits	123	Target Neighborhood Hits	65	Shared Neighborhood Hits	21
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.052149 (rank : 214)
Query Neighborhood Hits	123	Target Neighborhood Hits	44	Shared Neighborhood Hits	15
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1E_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.071570 (rank : 145)
Query Neighborhood Hits	123	Target Neighborhood Hits	53	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1F_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.063968 (rank : 156)
Query Neighborhood Hits	123	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE2B_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.058579 (rank : 176)
Query Neighborhood Hits	123	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2C_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.052803 (rank : 212)
Query Neighborhood Hits	123	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.055982 (rank : 195)
Query Neighborhood Hits	123	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE4A_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.090683 (rank : 118)
Query Neighborhood Hits	123	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

LTBP2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.051073 (rank : 220)
Query Neighborhood Hits	123	Target Neighborhood Hits	552	Shared Neighborhood Hits	52
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.053647 (rank : 209)
Query Neighborhood Hits	123	Target Neighborhood Hits	617	Shared Neighborhood Hits	55
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

NOTC1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.056875 (rank : 188)
Query Neighborhood Hits	123	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.059704 (rank : 169)
Query Neighborhood Hits	123	Target Neighborhood Hits	916	Shared Neighborhood Hits	56
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.056544 (rank : 192)
Query Neighborhood Hits	123	Target Neighborhood Hits	1113	Shared Neighborhood Hits	58
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.054415 (rank : 202)
Query Neighborhood Hits	123	Target Neighborhood Hits	1069	Shared Neighborhood Hits	53
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC3_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.062820 (rank : 159)
Query Neighborhood Hits	123	Target Neighborhood Hits	1062	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.056699 (rank : 191)
Query Neighborhood Hits	123	Target Neighborhood Hits	975	Shared Neighborhood Hits	61
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PCSK5_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.050588 (rank : 221)
Query Neighborhood Hits	123	Target Neighborhood Hits	613	Shared Neighborhood Hits	59
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PROP_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.132360 (rank : 70)
Query Neighborhood Hits	123	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.136068 (rank : 65)
Query Neighborhood Hits	123	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

RSPO4_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.067853 (rank : 150)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

SREC2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.056357 (rank : 193)
Query Neighborhood Hits	123	Target Neighborhood Hits	605	Shared Neighborhood Hits	55
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.084330 (rank : 122)
Query Neighborhood Hits	123	Target Neighborhood Hits	645	Shared Neighborhood Hits	62
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

STAB1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.054272 (rank : 204)
Query Neighborhood Hits	123	Target Neighborhood Hits	546	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

STAB1_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.056025 (rank : 194)
Query Neighborhood Hits	123	Target Neighborhood Hits	566	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

STAB2_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.054081 (rank : 206)
Query Neighborhood Hits	123	Target Neighborhood Hits	534	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

STAB2_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.053635 (rank : 210)
Query Neighborhood Hits	123	Target Neighborhood Hits	528	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TRBM_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.057410 (rank : 183)
Query Neighborhood Hits	123	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TSP3_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.056996 (rank : 185)
Query Neighborhood Hits	123	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP3_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.057283 (rank : 184)
Query Neighborhood Hits	123	Target Neighborhood Hits	247	Shared Neighborhood Hits	27
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP4_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.057648 (rank : 181)
Query Neighborhood Hits	123	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.057983 (rank : 179)
Query Neighborhood Hits	123	Target Neighborhood Hits	276	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

UNC5A_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.076211 (rank : 133)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5B_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.073681 (rank : 139)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.073979 (rank : 138)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5C_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.073009 (rank : 141)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	45
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.072666 (rank : 142)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5D_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.069176 (rank : 148)
Query Neighborhood Hits	123	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.068951 (rank : 149)
Query Neighborhood Hits	123	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

Hits sorted by NC score

WISP1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	123
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
NC score	0.991762 (rank : 2)	θ value	4.84403e-179 (rank : 2)
Query Neighborhood Hits	123	Target Neighborhood Hits	121	Shared Neighborhood Hits	102
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

CTGF_MOUSE
NC score	0.958570 (rank : 3)	θ value	1.31072e-83 (rank : 4)
Query Neighborhood Hits	123	Target Neighborhood Hits	124	Shared Neighborhood Hits	87
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

WISP3_HUMAN
NC score	0.956399 (rank : 4)	θ value	1.14825e-79 (rank : 5)
Query Neighborhood Hits	123	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

CTGF_HUMAN
NC score	0.956054 (rank : 5)	θ value	3.22093e-90 (rank : 3)
Query Neighborhood Hits	123	Target Neighborhood Hits	128	Shared Neighborhood Hits	85
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

NOV_MOUSE
NC score	0.950594 (rank : 6)	θ value	3.34864e-71 (rank : 9)
Query Neighborhood Hits	123	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_HUMAN
NC score	0.950088 (rank : 7)	θ value	2.31901e-72 (rank : 8)
Query Neighborhood Hits	123	Target Neighborhood Hits	128	Shared Neighborhood Hits	84
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CYR61_HUMAN
NC score	0.948317 (rank : 8)	θ value	1.22964e-73 (rank : 7)
Query Neighborhood Hits	123	Target Neighborhood Hits	159	Shared Neighborhood Hits	96
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
NC score	0.946402 (rank : 9)	θ value	5.51964e-74 (rank : 6)
Query Neighborhood Hits	123	Target Neighborhood Hits	156	Shared Neighborhood Hits	92
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

WISP2_HUMAN
NC score	0.922091 (rank : 10)	θ value	2.04573e-44 (rank : 11)
Query Neighborhood Hits	123	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
NC score	0.920769 (rank : 11)	θ value	3.98324e-48 (rank : 10)
Query Neighborhood Hits	123	Target Neighborhood Hits	129	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

BMPER_MOUSE
NC score	0.335731 (rank : 12)	θ value	2.88788e-06 (rank : 13)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

BMPER_HUMAN
NC score	0.330394 (rank : 13)	θ value	4.45536e-07 (rank : 12)
Query Neighborhood Hits	123	Target Neighborhood Hits	175	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

ESM1_MOUSE
NC score	0.298863 (rank : 14)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

CRIM1_HUMAN
NC score	0.293833 (rank : 15)	θ value	0.00020696 (rank : 17)
Query Neighborhood Hits	123	Target Neighborhood Hits	362	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CRDL2_HUMAN
NC score	0.289101 (rank : 16)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

CRDL2_MOUSE
NC score	0.279529 (rank : 17)	θ value	0.000158464 (rank : 16)
Query Neighborhood Hits	123	Target Neighborhood Hits	81	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

CRDL1_MOUSE
NC score	0.269388 (rank : 18)	θ value	0.0193708 (rank : 29)
Query Neighborhood Hits	123	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

ESM1_HUMAN
NC score	0.266023 (rank : 19)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

CRDL1_HUMAN
NC score	0.262373 (rank : 20)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	123	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

SSPO_MOUSE
NC score	0.241308 (rank : 21)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	123	Target Neighborhood Hits	800	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

HTRA4_HUMAN
NC score	0.214495 (rank : 22)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	123	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

SPON1_HUMAN
NC score	0.211249 (rank : 23)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	123	Target Neighborhood Hits	117	Shared Neighborhood Hits	59
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
NC score	0.209599 (rank : 24)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

TSP1_HUMAN
NC score	0.209431 (rank : 25)	θ value	0.00509761 (rank : 22)
Query Neighborhood Hits	123	Target Neighborhood Hits	389	Shared Neighborhood Hits	101
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
NC score	0.206161 (rank : 26)	θ value	0.00665767 (rank : 24)
Query Neighborhood Hits	123	Target Neighborhood Hits	396	Shared Neighborhood Hits	101
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

MUC5B_HUMAN
NC score	0.202155 (rank : 27)	θ value	0.000121331 (rank : 15)
Query Neighborhood Hits	123	Target Neighborhood Hits	1020	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

FRAS1_MOUSE
NC score	0.187464 (rank : 28)	θ value	0.000786445 (rank : 18)
Query Neighborhood Hits	123	Target Neighborhood Hits	747	Shared Neighborhood Hits	97
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

TSP2_HUMAN
NC score	0.185304 (rank : 29)	θ value	0.00665767 (rank : 25)
Query Neighborhood Hits	123	Target Neighborhood Hits	359	Shared Neighborhood Hits	99
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

FRAS1_HUMAN
NC score	0.185030 (rank : 30)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	123	Target Neighborhood Hits	759	Shared Neighborhood Hits	94
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

HTRA1_HUMAN
NC score	0.184883 (rank : 31)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	123	Target Neighborhood Hits	155	Shared Neighborhood Hits	34
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

VWF_MOUSE
NC score	0.184751 (rank : 32)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	123	Target Neighborhood Hits	381	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_HUMAN
NC score	0.184504 (rank : 33)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	123	Target Neighborhood Hits	396	Shared Neighborhood Hits	75
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATL2_HUMAN
NC score	0.182000 (rank : 34)	θ value	0.0736092 (rank : 40)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	61
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

TSP2_MOUSE
NC score	0.181900 (rank : 35)	θ value	0.0330416 (rank : 34)
Query Neighborhood Hits	123	Target Neighborhood Hits	352	Shared Neighborhood Hits	93
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

HTRA3_MOUSE
NC score	0.181300 (rank : 36)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	123	Target Neighborhood Hits	156	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA3_HUMAN
NC score	0.180543 (rank : 37)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	123	Target Neighborhood Hits	152	Shared Neighborhood Hits	35
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

ATL2_MOUSE
NC score	0.180499 (rank : 38)	θ value	0.0736092 (rank : 41)
Query Neighborhood Hits	123	Target Neighborhood Hits	137	Shared Neighborhood Hits	60
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

HTRA1_MOUSE
NC score	0.176329 (rank : 39)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	123	Target Neighborhood Hits	140	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

ZAN_MOUSE
NC score	0.174840 (rank : 40)	θ value	0.0563607 (rank : 39)
Query Neighborhood Hits	123	Target Neighborhood Hits	808	Shared Neighborhood Hits	81
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

NELL1_HUMAN
NC score	0.166357 (rank : 41)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	123	Target Neighborhood Hits	451	Shared Neighborhood Hits	63
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

IBP7_MOUSE
NC score	0.158733 (rank : 42)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	123	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

NELL2_MOUSE
NC score	0.156342 (rank : 43)	θ value	0.00175202 (rank : 21)
Query Neighborhood Hits	123	Target Neighborhood Hits	436	Shared Neighborhood Hits	61
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NELL2_HUMAN
NC score	0.155713 (rank : 44)	θ value	0.00665767 (rank : 23)
Query Neighborhood Hits	123	Target Neighborhood Hits	449	Shared Neighborhood Hits	61
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

ATS19_MOUSE
NC score	0.152707 (rank : 45)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	123	Target Neighborhood Hits	188	Shared Neighborhood Hits	58
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS12_HUMAN
NC score	0.152479 (rank : 46)	θ value	0.125558 (rank : 45)
Query Neighborhood Hits	123	Target Neighborhood Hits	251	Shared Neighborhood Hits	61
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS1_MOUSE
NC score	0.151301 (rank : 47)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	123	Target Neighborhood Hits	158	Shared Neighborhood Hits	58
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS9_HUMAN
NC score	0.150983 (rank : 48)	θ value	0.0736092 (rank : 42)
Query Neighborhood Hits	123	Target Neighborhood Hits	219	Shared Neighborhood Hits	65
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS19_HUMAN
NC score	0.150591 (rank : 49)	θ value	0.0252991 (rank : 30)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

IBP2_MOUSE
NC score	0.150386 (rank : 50)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	123	Target Neighborhood Hits	65	Shared Neighborhood Hits	26
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

ZAN_HUMAN
NC score	0.149480 (rank : 51)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	123	Target Neighborhood Hits	679	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ATS12_MOUSE
NC score	0.147544 (rank : 52)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	123	Target Neighborhood Hits	220	Shared Neighborhood Hits	58
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS20_MOUSE
NC score	0.147112 (rank : 53)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

IBP7_HUMAN
NC score	0.143350 (rank : 54)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	123	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

MUC2_HUMAN
NC score	0.143258 (rank : 55)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	123	Target Neighborhood Hits	906	Shared Neighborhood Hits	61
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ATS1_HUMAN
NC score	0.141048 (rank : 56)	θ value	1.06291 (rank : 78)
Query Neighborhood Hits	123	Target Neighborhood Hits	159	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS17_HUMAN
NC score	0.140707 (rank : 57)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS16_MOUSE
NC score	0.140388 (rank : 58)	θ value	0.125558 (rank : 46)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS18_MOUSE
NC score	0.140044 (rank : 59)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	123	Target Neighborhood Hits	163	Shared Neighborhood Hits	58
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATL3_HUMAN
NC score	0.139812 (rank : 60)	θ value	1.06291 (rank : 77)
Query Neighborhood Hits	123	Target Neighborhood Hits	414	Shared Neighborhood Hits	66
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATL5_HUMAN
NC score	0.139301 (rank : 61)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	123	Target Neighborhood Hits	103	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATS16_HUMAN
NC score	0.139033 (rank : 62)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	123	Target Neighborhood Hits	208	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS20_HUMAN
NC score	0.137350 (rank : 63)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	123	Target Neighborhood Hits	192	Shared Neighborhood Hits	65
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS18_HUMAN
NC score	0.136309 (rank : 64)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	123	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

PROP_MOUSE
NC score	0.136068 (rank : 65)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	123	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

BAI1_MOUSE
NC score	0.134833 (rank : 66)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	123	Target Neighborhood Hits	340	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

ATS15_HUMAN
NC score	0.134764 (rank : 67)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	123	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATL1_HUMAN
NC score	0.133293 (rank : 68)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	123	Target Neighborhood Hits	93	Shared Neighborhood Hits	54
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATS3_HUMAN
NC score	0.132796 (rank : 69)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

PROP_HUMAN
NC score	0.132360 (rank : 70)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	123	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

BAI1_HUMAN
NC score	0.131589 (rank : 71)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	123	Target Neighborhood Hits	375	Shared Neighborhood Hits	55
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

IBP2_HUMAN
NC score	0.130400 (rank : 72)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	123	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

ATS14_HUMAN
NC score	0.128084 (rank : 73)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	123	Target Neighborhood Hits	382	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

KR104_HUMAN
NC score	0.127837 (rank : 74)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	123	Target Neighborhood Hits	313	Shared Neighborhood Hits	63
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

BAI3_MOUSE
NC score	0.127569 (rank : 75)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	123	Target Neighborhood Hits	250	Shared Neighborhood Hits	55
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ATS2_MOUSE
NC score	0.126868 (rank : 76)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS13_HUMAN
NC score	0.126695 (rank : 77)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	123	Target Neighborhood Hits	238	Shared Neighborhood Hits	52
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

CHRD_HUMAN
NC score	0.126497 (rank : 78)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

ATS7_HUMAN
NC score	0.125859 (rank : 79)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	123	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

BAI2_MOUSE
NC score	0.125523 (rank : 80)	θ value	1.38821 (rank : 83)
Query Neighborhood Hits	123	Target Neighborhood Hits	323	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_HUMAN
NC score	0.124950 (rank : 81)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	123	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
NC score	0.124176 (rank : 82)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	123	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ATS13_MOUSE
NC score	0.122912 (rank : 83)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	123	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

IBP5_MOUSE
NC score	0.121138 (rank : 84)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

ATS6_HUMAN
NC score	0.120593 (rank : 85)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	123	Target Neighborhood Hits	141	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS2_HUMAN
NC score	0.120396 (rank : 86)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	123	Target Neighborhood Hits	179	Shared Neighborhood Hits	51
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

IBP5_HUMAN
NC score	0.119320 (rank : 87)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	27
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

CHRD_MOUSE
NC score	0.118436 (rank : 88)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

CI094_HUMAN
NC score	0.115781 (rank : 89)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	123	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

TECTA_MOUSE
NC score	0.114377 (rank : 90)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	123	Target Neighborhood Hits	244	Shared Neighborhood Hits	42
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

ATS8_MOUSE
NC score	0.114324 (rank : 91)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	123	Target Neighborhood Hits	139	Shared Neighborhood Hits	50
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS8_HUMAN
NC score	0.112383 (rank : 92)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	123	Target Neighborhood Hits	145	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATL1_MOUSE
NC score	0.112337 (rank : 93)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

SEM5A_HUMAN
NC score	0.111408 (rank : 94)	θ value	0.813845 (rank : 76)
Query Neighborhood Hits	123	Target Neighborhood Hits	177	Shared Neighborhood Hits	61
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

TECTA_HUMAN
NC score	0.110193 (rank : 95)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	123	Target Neighborhood Hits	239	Shared Neighborhood Hits	42
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

GRN_MOUSE
NC score	0.108740 (rank : 96)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	123	Target Neighborhood Hits	248	Shared Neighborhood Hits	45
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

ATS4_MOUSE
NC score	0.108689 (rank : 97)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	123	Target Neighborhood Hits	145	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS4_HUMAN
NC score	0.108290 (rank : 98)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	123	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

SEM5A_MOUSE
NC score	0.107981 (rank : 99)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	123	Target Neighborhood Hits	162	Shared Neighborhood Hits	59
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ATS5_MOUSE
NC score	0.107355 (rank : 100)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	123	Target Neighborhood Hits	147	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

MCSP_MOUSE
NC score	0.106840 (rank : 101)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	123	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

KAZD1_HUMAN
NC score	0.106240 (rank : 102)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	123	Target Neighborhood Hits	248	Shared Neighborhood Hits	32
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KR107_HUMAN
NC score	0.104942 (rank : 103)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	123	Target Neighborhood Hits	330	Shared Neighborhood Hits	57
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KAZD1_MOUSE
NC score	0.104231 (rank : 104)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	123	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

THSD1_HUMAN
NC score	0.103177 (rank : 105)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	123	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

THSD1_MOUSE
NC score	0.102291 (rank : 106)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ATS5_HUMAN
NC score	0.102205 (rank : 107)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	123	Target Neighborhood Hits	141	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

RECK_HUMAN
NC score	0.100759 (rank : 108)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	123	Target Neighborhood Hits	189	Shared Neighborhood Hits	47
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RECK_MOUSE
NC score	0.099712 (rank : 109)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	123	Target Neighborhood Hits	158	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

SEM5B_MOUSE
NC score	0.098045 (rank : 110)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	123	Target Neighborhood Hits	190	Shared Neighborhood Hits	57
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

CO1A1_MOUSE
NC score	0.098027 (rank : 111)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	123	Target Neighborhood Hits	457	Shared Neighborhood Hits	42
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

GRN_HUMAN
NC score	0.094193 (rank : 112)	θ value	0.21417 (rank : 59)
Query Neighborhood Hits	123	Target Neighborhood Hits	268	Shared Neighborhood Hits	42
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

SEM5B_HUMAN
NC score	0.094079 (rank : 113)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	123	Target Neighborhood Hits	178	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

KR106_HUMAN
NC score	0.093107 (rank : 114)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	123	Target Neighborhood Hits	347	Shared Neighborhood Hits	63
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

IBP1_HUMAN
NC score	0.092298 (rank : 115)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

HMCN1_HUMAN
NC score	0.091938 (rank : 116)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	123	Target Neighborhood Hits	983	Shared Neighborhood Hits	91
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

IBP3_HUMAN
NC score	0.091128 (rank : 117)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

LCE4A_HUMAN
NC score	0.090683 (rank : 118)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	123	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

IBP1_MOUSE
NC score	0.089415 (rank : 119)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	30
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

CO6_HUMAN
NC score	0.086139 (rank : 120)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	123	Target Neighborhood Hits	331	Shared Neighborhood Hits	62
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

MEGF6_HUMAN
NC score	0.086011 (rank : 121)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	123	Target Neighborhood Hits	671	Shared Neighborhood Hits	78
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

SREC_HUMAN
NC score	0.084330 (rank : 122)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	123	Target Neighborhood Hits	645	Shared Neighborhood Hits	62
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

KRA58_HUMAN
NC score	0.083370 (rank : 123)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	123	Target Neighborhood Hits	324	Shared Neighborhood Hits	43
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KR101_HUMAN
NC score	0.082393 (rank : 124)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	123	Target Neighborhood Hits	261	Shared Neighborhood Hits	56
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

CILP2_HUMAN
NC score	0.082301 (rank : 125)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	123	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

IBP3_MOUSE
NC score	0.082154 (rank : 126)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	123	Target Neighborhood Hits	60	Shared Neighborhood Hits	25
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

KR108_HUMAN
NC score	0.081834 (rank : 127)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	48
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

CILP1_MOUSE
NC score	0.079851 (rank : 128)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	123	Target Neighborhood Hits	282	Shared Neighborhood Hits	50
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

JAG1_MOUSE
NC score	0.079604 (rank : 129)	θ value	0.00102713 (rank : 19)
Query Neighborhood Hits	123	Target Neighborhood Hits	518	Shared Neighborhood Hits	57
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG1_HUMAN
NC score	0.079435 (rank : 130)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	123	Target Neighborhood Hits	514	Shared Neighborhood Hits	59
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

IBP4_MOUSE
NC score	0.077687 (rank : 131)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	123	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

KRA59_HUMAN
NC score	0.076359 (rank : 132)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	123	Target Neighborhood Hits	310	Shared Neighborhood Hits	41
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

UNC5A_MOUSE
NC score	0.076211 (rank : 133)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

SLIT2_HUMAN
NC score	0.075444 (rank : 134)	θ value	0.0148317 (rank : 27)
Query Neighborhood Hits	123	Target Neighborhood Hits	708	Shared Neighborhood Hits	49
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

KR109_HUMAN
NC score	0.074875 (rank : 135)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	49
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR105_HUMAN
NC score	0.074423 (rank : 136)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	123	Target Neighborhood Hits	271	Shared Neighborhood Hits	54
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

SLIT2_MOUSE
NC score	0.074073 (rank : 137)	θ value	0.0148317 (rank : 28)
Query Neighborhood Hits	123	Target Neighborhood Hits	684	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

UNC5B_MOUSE
NC score	0.073979 (rank : 138)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5B_HUMAN
NC score	0.073681 (rank : 139)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

KR10C_HUMAN
NC score	0.073027 (rank : 140)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	123	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

UNC5C_HUMAN
NC score	0.073009 (rank : 141)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	123	Target Neighborhood Hits	226	Shared Neighborhood Hits	45
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
NC score	0.072666 (rank : 142)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

IBP4_HUMAN
NC score	0.072412 (rank : 143)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	123	Target Neighborhood Hits	52	Shared Neighborhood Hits	18
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

KR102_HUMAN
NC score	0.071712 (rank : 144)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	123	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

LCE1E_HUMAN
NC score	0.071570 (rank : 145)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	123	Target Neighborhood Hits	53	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

CILP1_HUMAN
NC score	0.071166 (rank : 146)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	123	Target Neighborhood Hits	266	Shared Neighborhood Hits	48
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

TRBM_HUMAN
NC score	0.069542 (rank : 147)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	123	Target Neighborhood Hits	339	Shared Neighborhood Hits	46
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

UNC5D_HUMAN
NC score	0.069176 (rank : 148)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	123	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
NC score	0.068951 (rank : 149)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	123	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

RSPO4_HUMAN
NC score	0.067853 (rank : 150)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

AGRIN_HUMAN
NC score	0.067783 (rank : 151)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	123	Target Neighborhood Hits	582	Shared Neighborhood Hits	59
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

KR10B_HUMAN
NC score	0.067613 (rank : 152)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	123	Target Neighborhood Hits	269	Shared Neighborhood Hits	49
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

NOTC4_MOUSE
NC score	0.064799 (rank : 153)	θ value	0.813845 (rank : 75)
Query Neighborhood Hits	123	Target Neighborhood Hits	872	Shared Neighborhood Hits	58
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

KRA47_HUMAN
NC score	0.064636 (rank : 154)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	123	Target Neighborhood Hits	204	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

NOTC4_HUMAN
NC score	0.064537 (rank : 155)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	123	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

LCE1F_HUMAN
NC score	0.063968 (rank : 156)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	123	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

CO8B_MOUSE
NC score	0.063525 (rank : 157)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	123	Target Neighborhood Hits	224	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

JAG2_HUMAN
NC score	0.063139 (rank : 158)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	123	Target Neighborhood Hits	491	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

NOTC3_HUMAN
NC score	0.062820 (rank : 159)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	123	Target Neighborhood Hits	1062	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

LCE1C_HUMAN
NC score	0.062459 (rank : 160)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	123	Target Neighborhood Hits	65	Shared Neighborhood Hits	21
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

CO2A1_MOUSE
NC score	0.062181 (rank : 161)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	123	Target Neighborhood Hits	483	Shared Neighborhood Hits	33
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

JAG2_MOUSE
NC score	0.062117 (rank : 162)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	123	Target Neighborhood Hits	504	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

COMP_MOUSE
NC score	0.061140 (rank : 163)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	123	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

KRA92_HUMAN
NC score	0.060795 (rank : 164)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	123	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA53_HUMAN
NC score	0.060586 (rank : 165)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	123	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

CO1A1_HUMAN
NC score	0.060272 (rank : 166)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	123	Target Neighborhood Hits	475	Shared Neighborhood Hits	34
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

FBN2_HUMAN
NC score	0.060253 (rank : 167)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	123	Target Neighborhood Hits	560	Shared Neighborhood Hits	53
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

CO8B_HUMAN
NC score	0.059992 (rank : 168)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	123	Target Neighborhood Hits	199	Shared Neighborhood Hits	42
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

NOTC1_MOUSE
NC score	0.059704 (rank : 169)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	123	Target Neighborhood Hits	916	Shared Neighborhood Hits	56
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

KR414_HUMAN
NC score	0.059676 (rank : 170)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	123	Target Neighborhood Hits	199	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ6	Gene names	KRTAP4-14, KAP4.14, KRTAP4.14
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-14 (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14).

DLK_MOUSE
NC score	0.059595 (rank : 171)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	123	Target Neighborhood Hits	374	Shared Neighborhood Hits	42
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

CO8A_HUMAN
NC score	0.059247 (rank : 172)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	123	Target Neighborhood Hits	200	Shared Neighborhood Hits	48
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

LCE1A_HUMAN
NC score	0.058911 (rank : 173)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	123	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

FBN3_HUMAN
NC score	0.058886 (rank : 174)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	123	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FBN2_MOUSE
NC score	0.058883 (rank : 175)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	123	Target Neighborhood Hits	549	Shared Neighborhood Hits	53
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

LCE2B_HUMAN
NC score	0.058579 (rank : 176)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	123	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

FBN1_HUMAN
NC score	0.058524 (rank : 177)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	123	Target Neighborhood Hits	557	Shared Neighborhood Hits	53
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

CO8A_MOUSE
NC score	0.058453 (rank : 178)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	123	Target Neighborhood Hits	182	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

TSP4_MOUSE
NC score	0.057983 (rank : 179)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	123	Target Neighborhood Hits	276	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

KR412_HUMAN
NC score	0.057739 (rank : 180)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	123	Target Neighborhood Hits	178	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

TSP4_HUMAN
NC score	0.057648 (rank : 181)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	123	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

COMP_HUMAN
NC score	0.057556 (rank : 182)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	123	Target Neighborhood Hits	258	Shared Neighborhood Hits	29
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

TRBM_MOUSE
NC score	0.057410 (rank : 183)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	123	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TSP3_MOUSE
NC score	0.057283 (rank : 184)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	123	Target Neighborhood Hits	247	Shared Neighborhood Hits	27
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP3_HUMAN
NC score	0.056996 (rank : 185)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	123	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

CO7_HUMAN
NC score	0.056978 (rank : 186)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	123	Target Neighborhood Hits	278	Shared Neighborhood Hits	53
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

SOSD1_HUMAN
NC score	0.056935 (rank : 187)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X4U4, Q96HJ7, Q9Y3U3	Gene names	SOSTDC1, USAG1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1).

NOTC1_HUMAN
NC score	0.056875 (rank : 188)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	123	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

KRA45_HUMAN
NC score	0.056872 (rank : 189)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	123	Target Neighborhood Hits	194	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

CO5A2_HUMAN
NC score	0.056807 (rank : 190)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	123	Target Neighborhood Hits	760	Shared Neighborhood Hits	44
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

NOTC3_MOUSE
NC score	0.056699 (rank : 191)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	123	Target Neighborhood Hits	975	Shared Neighborhood Hits	61
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC2_HUMAN
NC score	0.056544 (rank : 192)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	123	Target Neighborhood Hits	1113	Shared Neighborhood Hits	58
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SREC2_MOUSE
NC score	0.056357 (rank : 193)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	123	Target Neighborhood Hits	605	Shared Neighborhood Hits	55
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

STAB1_MOUSE
NC score	0.056025 (rank : 194)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	123	Target Neighborhood Hits	566	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

LCE2D_HUMAN
NC score	0.055982 (rank : 195)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	123	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

FBN1_MOUSE
NC score	0.055713 (rank : 196)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	123	Target Neighborhood Hits	563	Shared Neighborhood Hits	52
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

SOSD1_MOUSE
NC score	0.055428 (rank : 197)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQN4, Q8CF09	Gene names	Sostdc1, Sostl, Usag1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) (Sclerostin-like protein).

KR10A_HUMAN
NC score	0.055125 (rank : 198)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	123	Target Neighborhood Hits	232	Shared Neighborhood Hits	46
SwissProt Accessions	P60014	Gene names	KRTAP10-10, KAP10.10, KAP18-10, KRTAP10.10, KRTAP18-1, KRTAP18.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-10 (Keratin-associated protein 10.10) (High sulfur keratin-associated protein 10.10) (Keratin-associated protein 18-10) (Keratin-associated protein 18.10).

SLIT1_HUMAN
NC score	0.055029 (rank : 199)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	123	Target Neighborhood Hits	700	Shared Neighborhood Hits	45
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

LCE1B_HUMAN
NC score	0.055004 (rank : 200)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	123	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

KRA51_HUMAN
NC score	0.054629 (rank : 201)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	123	Target Neighborhood Hits	288	Shared Neighborhood Hits	41
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

NOTC2_MOUSE
NC score	0.054415 (rank : 202)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	123	Target Neighborhood Hits	1069	Shared Neighborhood Hits	53
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

KR103_HUMAN
NC score	0.054372 (rank : 203)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	123	Target Neighborhood Hits	212	Shared Neighborhood Hits	43
SwissProt Accessions	P60369, Q70LJ4	Gene names	KRTAP10-3, KAP10.3, KAP18-3, KRTAP10.3, KRTAP18-3, KRTAP18.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-3 (Keratin-associated protein 10.3) (High sulfur keratin-associated protein 10.3) (Keratin-associated protein 18-3) (Keratin-associated protein 18.3).

STAB1_HUMAN
NC score	0.054272 (rank : 204)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	123	Target Neighborhood Hits	546	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

KRA98_HUMAN
NC score	0.054145 (rank : 205)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	123	Target Neighborhood Hits	185	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

STAB2_HUMAN
NC score	0.054081 (rank : 206)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	123	Target Neighborhood Hits	534	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

KRA93_HUMAN
NC score	0.054058 (rank : 207)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	123	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

EGFL9_MOUSE
NC score	0.053892 (rank : 208)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	123	Target Neighborhood Hits	379	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

LTBP2_MOUSE
NC score	0.053647 (rank : 209)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	123	Target Neighborhood Hits	617	Shared Neighborhood Hits	55
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

STAB2_MOUSE
NC score	0.053635 (rank : 210)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	123	Target Neighborhood Hits	528	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

FBLN1_HUMAN
NC score	0.053173 (rank : 211)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	123	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

LCE2C_HUMAN
NC score	0.052803 (rank : 212)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	123	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

DLL1_MOUSE
NC score	0.052417 (rank : 213)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	123	Target Neighborhood Hits	456	Shared Neighborhood Hits	43
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

LCE1D_HUMAN
NC score	0.052149 (rank : 214)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	123	Target Neighborhood Hits	44	Shared Neighborhood Hits	15
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

SREC2_HUMAN
NC score	0.052087 (rank : 215)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	123	Target Neighborhood Hits	645	Shared Neighborhood Hits	49
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SLIT3_MOUSE
NC score	0.051978 (rank : 216)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	123	Target Neighborhood Hits	700	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLIT1_MOUSE
NC score	0.051929 (rank : 217)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	123	Target Neighborhood Hits	715	Shared Neighborhood Hits	45
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

FBLN2_MOUSE
NC score	0.051530 (rank : 218)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	123	Target Neighborhood Hits	505	Shared Neighborhood Hits	53
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

DLL3_HUMAN
NC score	0.051155 (rank : 219)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	123	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

LTBP2_HUMAN
NC score	0.051073 (rank : 220)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	123	Target Neighborhood Hits	552	Shared Neighborhood Hits	52
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

PCSK5_MOUSE
NC score	0.050588 (rank : 221)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	123	Target Neighborhood Hits	613	Shared Neighborhood Hits	59
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

KRA57_HUMAN
NC score	0.050355 (rank : 222)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	123	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA13_HUMAN
NC score	0.050346 (rank : 223)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	123	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IUG1, Q07628, Q8IUG0, Q9BYS2	Gene names	KRTAP1-3, B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9).

DLL4_MOUSE
NC score	0.050329 (rank : 224)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	123	Target Neighborhood Hits	440	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

ECM2_HUMAN
NC score	0.045167 (rank : 225)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	123	Target Neighborhood Hits	402	Shared Neighborhood Hits	39
SwissProt Accessions	O94769	Gene names	ECM2
Domain Architecture
Description	Extracellular matrix protein 2 precursor (Matrix glycoprotein SC1/ECM2).

TNR8_HUMAN
NC score	0.036028 (rank : 226)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	123	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

MATN3_MOUSE
NC score	0.035728 (rank : 227)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	123	Target Neighborhood Hits	261	Shared Neighborhood Hits	34
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

TINAG_HUMAN
NC score	0.032812 (rank : 228)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

PAPPA_HUMAN
NC score	0.030957 (rank : 229)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	123	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

PAPPA_MOUSE
NC score	0.024547 (rank : 230)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).