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Network neighborhood for query Sequence : ATS17_HUMAN

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ATS17_HUMAN
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATS17_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	194	Target Neighborhood Hits	194	Shared Neighborhood Hits	194
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS19_HUMAN
θ value	0 (rank : 2)	NC score	0.984899 (rank : 3)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	144
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS19_MOUSE
θ value	0 (rank : 3)	NC score	0.987030 (rank : 2)
Query Neighborhood Hits	194	Target Neighborhood Hits	188	Shared Neighborhood Hits	149
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS18_HUMAN
θ value	1.41924e-154 (rank : 4)	NC score	0.977287 (rank : 4)
Query Neighborhood Hits	194	Target Neighborhood Hits	169	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS18_MOUSE
θ value	9.19922e-154 (rank : 5)	NC score	0.977065 (rank : 5)
Query Neighborhood Hits	194	Target Neighborhood Hits	163	Shared Neighborhood Hits	135
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS12_HUMAN
θ value	1.33145e-144 (rank : 6)	NC score	0.974003 (rank : 9)
Query Neighborhood Hits	194	Target Neighborhood Hits	251	Shared Neighborhood Hits	136
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS16_HUMAN
θ value	4.73554e-142 (rank : 7)	NC score	0.974874 (rank : 8)
Query Neighborhood Hits	194	Target Neighborhood Hits	208	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_MOUSE
θ value	6.18479e-142 (rank : 8)	NC score	0.975123 (rank : 7)
Query Neighborhood Hits	194	Target Neighborhood Hits	220	Shared Neighborhood Hits	136
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS16_MOUSE
θ value	1.98959e-140 (rank : 9)	NC score	0.975645 (rank : 6)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS20_MOUSE
θ value	9.58617e-127 (rank : 10)	NC score	0.965980 (rank : 17)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	139
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS20_HUMAN
θ value	2.78914e-126 (rank : 11)	NC score	0.966746 (rank : 15)
Query Neighborhood Hits	194	Target Neighborhood Hits	192	Shared Neighborhood Hits	144
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS7_HUMAN
θ value	4.75757e-126 (rank : 12)	NC score	0.972735 (rank : 10)
Query Neighborhood Hits	194	Target Neighborhood Hits	169	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS9_HUMAN
θ value	1.93603e-119 (rank : 13)	NC score	0.965683 (rank : 18)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	140
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS2_HUMAN
θ value	3.65119e-118 (rank : 14)	NC score	0.969328 (rank : 13)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS3_HUMAN
θ value	3.65119e-118 (rank : 15)	NC score	0.972020 (rank : 11)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	140
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS2_MOUSE
θ value	2.00348e-116 (rank : 16)	NC score	0.968514 (rank : 14)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	133
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS14_HUMAN
θ value	6.6695e-112 (rank : 17)	NC score	0.962045 (rank : 21)
Query Neighborhood Hits	194	Target Neighborhood Hits	382	Shared Neighborhood Hits	135
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS1_MOUSE
θ value	2.00813e-108 (rank : 18)	NC score	0.965571 (rank : 19)
Query Neighborhood Hits	194	Target Neighborhood Hits	158	Shared Neighborhood Hits	132
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS15_HUMAN
θ value	5.84277e-108 (rank : 19)	NC score	0.966713 (rank : 16)
Query Neighborhood Hits	194	Target Neighborhood Hits	151	Shared Neighborhood Hits	133
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS1_HUMAN
θ value	1.1019e-106 (rank : 20)	NC score	0.964020 (rank : 20)
Query Neighborhood Hits	194	Target Neighborhood Hits	159	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS6_HUMAN
θ value	2.15048e-102 (rank : 21)	NC score	0.970284 (rank : 12)
Query Neighborhood Hits	194	Target Neighborhood Hits	141	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS5_HUMAN
θ value	9.34977e-98 (rank : 22)	NC score	0.959144 (rank : 24)
Query Neighborhood Hits	194	Target Neighborhood Hits	141	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
θ value	7.91507e-97 (rank : 23)	NC score	0.961523 (rank : 22)
Query Neighborhood Hits	194	Target Neighborhood Hits	147	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS13_HUMAN
θ value	1.82472e-93 (rank : 24)	NC score	0.941179 (rank : 28)
Query Neighborhood Hits	194	Target Neighborhood Hits	238	Shared Neighborhood Hits	137
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
θ value	3.56116e-89 (rank : 25)	NC score	0.938792 (rank : 29)
Query Neighborhood Hits	194	Target Neighborhood Hits	227	Shared Neighborhood Hits	139
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS4_MOUSE
θ value	1.07224e-85 (rank : 26)	NC score	0.949305 (rank : 26)
Query Neighborhood Hits	194	Target Neighborhood Hits	145	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS8_HUMAN
θ value	1.82896e-85 (rank : 27)	NC score	0.959448 (rank : 23)
Query Neighborhood Hits	194	Target Neighborhood Hits	145	Shared Neighborhood Hits	119
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS4_HUMAN
θ value	4.07447e-85 (rank : 28)	NC score	0.947629 (rank : 27)
Query Neighborhood Hits	194	Target Neighborhood Hits	138	Shared Neighborhood Hits	112
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS8_MOUSE
θ value	9.7205e-79 (rank : 29)	NC score	0.953494 (rank : 25)
Query Neighborhood Hits	194	Target Neighborhood Hits	139	Shared Neighborhood Hits	121
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATL3_HUMAN
θ value	7.98882e-65 (rank : 30)	NC score	0.762500 (rank : 35)
Query Neighborhood Hits	194	Target Neighborhood Hits	414	Shared Neighborhood Hits	97
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATL1_HUMAN
θ value	6.55044e-59 (rank : 31)	NC score	0.900141 (rank : 30)
Query Neighborhood Hits	194	Target Neighborhood Hits	93	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL1_MOUSE
θ value	6.15952e-41 (rank : 32)	NC score	0.891074 (rank : 32)
Query Neighborhood Hits	194	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL5_HUMAN
θ value	6.17384e-33 (rank : 33)	NC score	0.892562 (rank : 31)
Query Neighborhood Hits	194	Target Neighborhood Hits	103	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATL2_HUMAN
θ value	1.37539e-32 (rank : 34)	NC score	0.858130 (rank : 34)
Query Neighborhood Hits	194	Target Neighborhood Hits	125	Shared Neighborhood Hits	89
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL2_MOUSE
θ value	2.34606e-32 (rank : 35)	NC score	0.858886 (rank : 33)
Query Neighborhood Hits	194	Target Neighborhood Hits	137	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

CI094_HUMAN
θ value	1.4233e-29 (rank : 36)	NC score	0.587472 (rank : 40)
Query Neighborhood Hits	194	Target Neighborhood Hits	310	Shared Neighborhood Hits	77
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ADAM8_MOUSE
θ value	2.77775e-25 (rank : 37)	NC score	0.587467 (rank : 41)
Query Neighborhood Hits	194	Target Neighborhood Hits	326	Shared Neighborhood Hits	95
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

ADAM8_HUMAN
θ value	1.09232e-21 (rank : 38)	NC score	0.585859 (rank : 42)
Query Neighborhood Hits	194	Target Neighborhood Hits	327	Shared Neighborhood Hits	88
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

ADA12_HUMAN
θ value	2.69047e-20 (rank : 39)	NC score	0.562470 (rank : 48)
Query Neighborhood Hits	194	Target Neighborhood Hits	224	Shared Neighborhood Hits	84
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA15_HUMAN
θ value	1.74391e-19 (rank : 40)	NC score	0.542894 (rank : 52)
Query Neighborhood Hits	194	Target Neighborhood Hits	288	Shared Neighborhood Hits	90
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADA15_MOUSE
θ value	1.24977e-17 (rank : 41)	NC score	0.516782 (rank : 57)
Query Neighborhood Hits	194	Target Neighborhood Hits	324	Shared Neighborhood Hits	96
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADA12_MOUSE
θ value	2.13179e-17 (rank : 42)	NC score	0.553260 (rank : 50)
Query Neighborhood Hits	194	Target Neighborhood Hits	474	Shared Neighborhood Hits	88
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA19_MOUSE
θ value	6.20254e-17 (rank : 43)	NC score	0.579566 (rank : 43)
Query Neighborhood Hits	194	Target Neighborhood Hits	315	Shared Neighborhood Hits	93
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

ADAM9_HUMAN
θ value	8.10077e-17 (rank : 44)	NC score	0.533630 (rank : 55)
Query Neighborhood Hits	194	Target Neighborhood Hits	243	Shared Neighborhood Hits	86
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

ADAM9_MOUSE
θ value	8.10077e-17 (rank : 45)	NC score	0.542300 (rank : 54)
Query Neighborhood Hits	194	Target Neighborhood Hits	325	Shared Neighborhood Hits	90
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

ADA28_MOUSE
θ value	1.38178e-16 (rank : 46)	NC score	0.578707 (rank : 44)
Query Neighborhood Hits	194	Target Neighborhood Hits	241	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

BAI3_HUMAN
θ value	2.35696e-16 (rank : 47)	NC score	0.478409 (rank : 74)
Query Neighborhood Hits	194	Target Neighborhood Hits	246	Shared Neighborhood Hits	90
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI1_HUMAN
θ value	4.02038e-16 (rank : 48)	NC score	0.477542 (rank : 75)
Query Neighborhood Hits	194	Target Neighborhood Hits	375	Shared Neighborhood Hits	94
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	5.25075e-16 (rank : 49)	NC score	0.479416 (rank : 72)
Query Neighborhood Hits	194	Target Neighborhood Hits	340	Shared Neighborhood Hits	91
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

SSPO_MOUSE
θ value	5.25075e-16 (rank : 50)	NC score	0.432793 (rank : 97)
Query Neighborhood Hits	194	Target Neighborhood Hits	800	Shared Neighborhood Hits	146
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ADA21_MOUSE
θ value	8.95645e-16 (rank : 51)	NC score	0.505082 (rank : 61)
Query Neighborhood Hits	194	Target Neighborhood Hits	172	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

BAI3_MOUSE
θ value	2.60593e-15 (rank : 52)	NC score	0.477485 (rank : 76)
Query Neighborhood Hits	194	Target Neighborhood Hits	250	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ADA25_MOUSE
θ value	9.90251e-15 (rank : 53)	NC score	0.493369 (rank : 65)
Query Neighborhood Hits	194	Target Neighborhood Hits	213	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

ADAM7_HUMAN
θ value	1.68911e-14 (rank : 54)	NC score	0.546186 (rank : 51)
Query Neighborhood Hits	194	Target Neighborhood Hits	221	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

ADA19_HUMAN
θ value	4.91457e-14 (rank : 55)	NC score	0.570229 (rank : 45)
Query Neighborhood Hits	194	Target Neighborhood Hits	381	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA21_HUMAN
θ value	8.38298e-14 (rank : 56)	NC score	0.489817 (rank : 67)
Query Neighborhood Hits	194	Target Neighborhood Hits	181	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

BAI2_MOUSE
θ value	3.18553e-13 (rank : 57)	NC score	0.476237 (rank : 79)
Query Neighborhood Hits	194	Target Neighborhood Hits	323	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

PROP_HUMAN
θ value	3.18553e-13 (rank : 58)	NC score	0.647001 (rank : 36)
Query Neighborhood Hits	194	Target Neighborhood Hits	126	Shared Neighborhood Hits	85
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

SEM5B_HUMAN
θ value	3.18553e-13 (rank : 59)	NC score	0.425797 (rank : 100)
Query Neighborhood Hits	194	Target Neighborhood Hits	178	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

BAI2_HUMAN
θ value	4.16044e-13 (rank : 60)	NC score	0.479030 (rank : 73)
Query Neighborhood Hits	194	Target Neighborhood Hits	332	Shared Neighborhood Hits	96
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

HMCN1_HUMAN
θ value	4.16044e-13 (rank : 61)	NC score	0.293605 (rank : 118)
Query Neighborhood Hits	194	Target Neighborhood Hits	983	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

SEM5B_MOUSE
θ value	7.09661e-13 (rank : 62)	NC score	0.427975 (rank : 99)
Query Neighborhood Hits	194	Target Neighborhood Hits	190	Shared Neighborhood Hits	92
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SEM5A_HUMAN
θ value	1.58096e-12 (rank : 63)	NC score	0.438563 (rank : 95)
Query Neighborhood Hits	194	Target Neighborhood Hits	177	Shared Neighborhood Hits	90
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5A_MOUSE
θ value	4.59992e-12 (rank : 64)	NC score	0.428968 (rank : 98)
Query Neighborhood Hits	194	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

TSP1_MOUSE
θ value	6.00763e-12 (rank : 65)	NC score	0.472944 (rank : 81)
Query Neighborhood Hits	194	Target Neighborhood Hits	396	Shared Neighborhood Hits	107
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_MOUSE
θ value	6.00763e-12 (rank : 66)	NC score	0.470454 (rank : 82)
Query Neighborhood Hits	194	Target Neighborhood Hits	352	Shared Neighborhood Hits	100
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

ADA33_HUMAN
θ value	7.84624e-12 (rank : 67)	NC score	0.561655 (rank : 49)
Query Neighborhood Hits	194	Target Neighborhood Hits	264	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

TSP1_HUMAN
θ value	1.02475e-11 (rank : 68)	NC score	0.473110 (rank : 80)
Query Neighborhood Hits	194	Target Neighborhood Hits	389	Shared Neighborhood Hits	105
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

ADA28_HUMAN
θ value	3.89403e-11 (rank : 69)	NC score	0.566596 (rank : 46)
Query Neighborhood Hits	194	Target Neighborhood Hits	244	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

ADM1B_MOUSE
θ value	3.89403e-11 (rank : 70)	NC score	0.509086 (rank : 60)
Query Neighborhood Hits	194	Target Neighborhood Hits	236	Shared Neighborhood Hits	89
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

TSP2_HUMAN
θ value	3.89403e-11 (rank : 71)	NC score	0.467158 (rank : 86)
Query Neighborhood Hits	194	Target Neighborhood Hits	359	Shared Neighborhood Hits	104
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ADM1A_MOUSE
θ value	1.133e-10 (rank : 72)	NC score	0.499648 (rank : 62)
Query Neighborhood Hits	194	Target Neighborhood Hits	230	Shared Neighborhood Hits	83
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

SPON1_HUMAN
θ value	1.133e-10 (rank : 73)	NC score	0.598155 (rank : 38)
Query Neighborhood Hits	194	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

ADA11_MOUSE
θ value	2.52405e-10 (rank : 74)	NC score	0.468563 (rank : 84)
Query Neighborhood Hits	194	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

PROP_MOUSE
θ value	2.52405e-10 (rank : 75)	NC score	0.639190 (rank : 37)
Query Neighborhood Hits	194	Target Neighborhood Hits	165	Shared Neighborhood Hits	90
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

SPON1_MOUSE
θ value	2.52405e-10 (rank : 76)	NC score	0.597101 (rank : 39)
Query Neighborhood Hits	194	Target Neighborhood Hits	123	Shared Neighborhood Hits	96
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

UNC5A_MOUSE
θ value	3.29651e-10 (rank : 77)	NC score	0.481164 (rank : 70)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ADA29_HUMAN
θ value	7.34386e-10 (rank : 78)	NC score	0.492072 (rank : 66)
Query Neighborhood Hits	194	Target Neighborhood Hits	247	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ADEC1_HUMAN
θ value	7.34386e-10 (rank : 79)	NC score	0.562614 (rank : 47)
Query Neighborhood Hits	194	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA20_HUMAN
θ value	9.59137e-10 (rank : 80)	NC score	0.448693 (rank : 89)
Query Neighborhood Hits	194	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

UNC5C_HUMAN
θ value	9.59137e-10 (rank : 81)	NC score	0.453965 (rank : 88)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	79
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	9.59137e-10 (rank : 82)	NC score	0.454461 (rank : 87)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	79
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5D_HUMAN
θ value	9.59137e-10 (rank : 83)	NC score	0.446276 (rank : 90)
Query Neighborhood Hits	194	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA24_MOUSE
θ value	1.63604e-09 (rank : 84)	NC score	0.498560 (rank : 64)
Query Neighborhood Hits	194	Target Neighborhood Hits	230	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

UNC5D_MOUSE
θ value	2.13673e-09 (rank : 85)	NC score	0.442563 (rank : 93)
Query Neighborhood Hits	194	Target Neighborhood Hits	268	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADAM7_MOUSE
θ value	2.79066e-09 (rank : 86)	NC score	0.542539 (rank : 53)
Query Neighborhood Hits	194	Target Neighborhood Hits	200	Shared Neighborhood Hits	84
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

ADA22_HUMAN
θ value	6.21693e-09 (rank : 87)	NC score	0.498642 (rank : 63)
Query Neighborhood Hits	194	Target Neighborhood Hits	211	Shared Neighborhood Hits	87
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

UNC5B_HUMAN
θ value	6.21693e-09 (rank : 88)	NC score	0.467363 (rank : 85)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

ADA33_MOUSE
θ value	8.11959e-09 (rank : 89)	NC score	0.533529 (rank : 56)
Query Neighborhood Hits	194	Target Neighborhood Hits	231	Shared Neighborhood Hits	90
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

UNC5B_MOUSE
θ value	8.11959e-09 (rank : 90)	NC score	0.469646 (rank : 83)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

ADEC1_MOUSE
θ value	3.08544e-08 (rank : 91)	NC score	0.513427 (rank : 58)
Query Neighborhood Hits	194	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA17_MOUSE
θ value	4.0297e-08 (rank : 92)	NC score	0.404709 (rank : 106)
Query Neighborhood Hits	194	Target Neighborhood Hits	201	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

CO8A_MOUSE
θ value	4.0297e-08 (rank : 93)	NC score	0.417977 (rank : 104)
Query Neighborhood Hits	194	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ADA22_MOUSE
θ value	3.41135e-07 (rank : 94)	NC score	0.487799 (rank : 68)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

UNC5A_HUMAN
θ value	3.41135e-07 (rank : 95)	NC score	0.392798 (rank : 110)
Query Neighborhood Hits	194	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CO6_HUMAN
θ value	4.45536e-07 (rank : 96)	NC score	0.419968 (rank : 103)
Query Neighborhood Hits	194	Target Neighborhood Hits	331	Shared Neighborhood Hits	89
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ADA11_HUMAN
θ value	9.92553e-07 (rank : 97)	NC score	0.444388 (rank : 91)
Query Neighborhood Hits	194	Target Neighborhood Hits	259	Shared Neighborhood Hits	86
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADA32_MOUSE
θ value	1.29631e-06 (rank : 98)	NC score	0.439638 (rank : 94)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

CO8A_HUMAN
θ value	2.21117e-06 (rank : 99)	NC score	0.424181 (rank : 101)
Query Neighborhood Hits	194	Target Neighborhood Hits	200	Shared Neighborhood Hits	72
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CO8B_MOUSE
θ value	2.21117e-06 (rank : 100)	NC score	0.400338 (rank : 108)
Query Neighborhood Hits	194	Target Neighborhood Hits	224	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADAM2_MOUSE
θ value	2.88788e-06 (rank : 101)	NC score	0.444372 (rank : 92)
Query Neighborhood Hits	194	Target Neighborhood Hits	209	Shared Neighborhood Hits	84
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

ADA18_HUMAN
θ value	6.43352e-06 (rank : 102)	NC score	0.399129 (rank : 109)
Query Neighborhood Hits	194	Target Neighborhood Hits	184	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

ADA17_HUMAN
θ value	1.09739e-05 (rank : 103)	NC score	0.391064 (rank : 111)
Query Neighborhood Hits	194	Target Neighborhood Hits	223	Shared Neighborhood Hits	90
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

PCSK6_HUMAN
θ value	1.87187e-05 (rank : 104)	NC score	0.056429 (rank : 166)
Query Neighborhood Hits	194	Target Neighborhood Hits	298	Shared Neighborhood Hits	33
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

ADA18_MOUSE
θ value	3.19293e-05 (rank : 105)	NC score	0.421275 (rank : 102)
Query Neighborhood Hits	194	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

CILP2_HUMAN
θ value	3.19293e-05 (rank : 106)	NC score	0.400899 (rank : 107)
Query Neighborhood Hits	194	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

THSD1_HUMAN
θ value	3.19293e-05 (rank : 107)	NC score	0.510946 (rank : 59)
Query Neighborhood Hits	194	Target Neighborhood Hits	136	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA23_MOUSE
θ value	0.000121331 (rank : 108)	NC score	0.484488 (rank : 69)
Query Neighborhood Hits	194	Target Neighborhood Hits	245	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

ADA23_HUMAN
θ value	0.000158464 (rank : 109)	NC score	0.477372 (rank : 77)
Query Neighborhood Hits	194	Target Neighborhood Hits	235	Shared Neighborhood Hits	86
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

AD26A_MOUSE
θ value	0.000602161 (rank : 110)	NC score	0.480868 (rank : 71)
Query Neighborhood Hits	194	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

THSD1_MOUSE
θ value	0.000602161 (rank : 111)	NC score	0.477010 (rank : 78)
Query Neighborhood Hits	194	Target Neighborhood Hits	153	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA32_HUMAN
θ value	0.00102713 (rank : 112)	NC score	0.437540 (rank : 96)
Query Neighborhood Hits	194	Target Neighborhood Hits	216	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

CO7_HUMAN
θ value	0.00134147 (rank : 113)	NC score	0.367863 (rank : 115)
Query Neighborhood Hits	194	Target Neighborhood Hits	278	Shared Neighborhood Hits	79
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

ADA30_HUMAN
θ value	0.00175202 (rank : 114)	NC score	0.390429 (rank : 112)
Query Neighborhood Hits	194	Target Neighborhood Hits	391	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

CILP1_HUMAN
θ value	0.00298849 (rank : 115)	NC score	0.293470 (rank : 119)
Query Neighborhood Hits	194	Target Neighborhood Hits	266	Shared Neighborhood Hits	79
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ALK1_MOUSE
θ value	0.00509761 (rank : 116)	NC score	0.042370 (rank : 183)
Query Neighborhood Hits	194	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P97430, O09081, O09082	Gene names	Slpi
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (Secretory leukocyte protease inhibitor).

CILP1_MOUSE
θ value	0.0113563 (rank : 117)	NC score	0.296989 (rank : 117)
Query Neighborhood Hits	194	Target Neighborhood Hits	282	Shared Neighborhood Hits	78
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

LAMC1_MOUSE
θ value	0.0113563 (rank : 118)	NC score	0.021370 (rank : 208)
Query Neighborhood Hits	194	Target Neighborhood Hits	856	Shared Neighborhood Hits	41
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

CO8B_HUMAN
θ value	0.0193708 (rank : 119)	NC score	0.360785 (rank : 116)
Query Neighborhood Hits	194	Target Neighborhood Hits	199	Shared Neighborhood Hits	72
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADAM2_HUMAN
θ value	0.0252991 (rank : 120)	NC score	0.408728 (rank : 105)
Query Neighborhood Hits	194	Target Neighborhood Hits	175	Shared Neighborhood Hits	75
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

PCSK5_HUMAN
θ value	0.0330416 (rank : 121)	NC score	0.050300 (rank : 177)
Query Neighborhood Hits	194	Target Neighborhood Hits	291	Shared Neighborhood Hits	38
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

NFX1_HUMAN
θ value	0.0431538 (rank : 122)	NC score	0.068408 (rank : 151)
Query Neighborhood Hits	194	Target Neighborhood Hits	405	Shared Neighborhood Hits	41
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

PCSK5_MOUSE
θ value	0.0431538 (rank : 123)	NC score	0.067166 (rank : 154)
Query Neighborhood Hits	194	Target Neighborhood Hits	613	Shared Neighborhood Hits	72
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

MMP26_HUMAN
θ value	0.0961366 (rank : 124)	NC score	0.067122 (rank : 155)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

RSPO1_MOUSE
θ value	0.0961366 (rank : 125)	NC score	0.095073 (rank : 135)
Query Neighborhood Hits	194	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

ADA10_HUMAN
θ value	0.163984 (rank : 126)	NC score	0.381463 (rank : 114)
Query Neighborhood Hits	194	Target Neighborhood Hits	189	Shared Neighborhood Hits	76
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

ADA10_MOUSE
θ value	0.163984 (rank : 127)	NC score	0.382989 (rank : 113)
Query Neighborhood Hits	194	Target Neighborhood Hits	194	Shared Neighborhood Hits	77
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

MMP13_MOUSE
θ value	0.163984 (rank : 128)	NC score	0.043449 (rank : 182)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

APOA_HUMAN
θ value	0.279714 (rank : 129)	NC score	0.004198 (rank : 216)
Query Neighborhood Hits	194	Target Neighborhood Hits	221	Shared Neighborhood Hits	7
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

FRAS1_HUMAN
θ value	0.279714 (rank : 130)	NC score	0.092939 (rank : 138)
Query Neighborhood Hits	194	Target Neighborhood Hits	759	Shared Neighborhood Hits	99
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
θ value	0.279714 (rank : 131)	NC score	0.106544 (rank : 129)
Query Neighborhood Hits	194	Target Neighborhood Hits	747	Shared Neighborhood Hits	102
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

LAMC1_HUMAN
θ value	0.279714 (rank : 132)	NC score	0.019392 (rank : 209)
Query Neighborhood Hits	194	Target Neighborhood Hits	922	Shared Neighborhood Hits	44
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

NOV_HUMAN
θ value	0.279714 (rank : 133)	NC score	0.107329 (rank : 128)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

BRWD1_MOUSE
θ value	0.365318 (rank : 134)	NC score	0.002697 (rank : 217)
Query Neighborhood Hits	194	Target Neighborhood Hits	478	Shared Neighborhood Hits	3
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

CYR61_HUMAN
θ value	0.365318 (rank : 135)	NC score	0.126727 (rank : 124)
Query Neighborhood Hits	194	Target Neighborhood Hits	159	Shared Neighborhood Hits	72
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

MMP1B_MOUSE
θ value	0.365318 (rank : 136)	NC score	0.042204 (rank : 185)
Query Neighborhood Hits	194	Target Neighborhood Hits	64	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

MK_MOUSE
θ value	0.47712 (rank : 137)	NC score	0.050605 (rank : 176)
Query Neighborhood Hits	194	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

MMP13_HUMAN
θ value	0.47712 (rank : 138)	NC score	0.039661 (rank : 188)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	30
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP7_HUMAN
θ value	0.47712 (rank : 139)	NC score	0.038840 (rank : 189)
Query Neighborhood Hits	194	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

WISP2_MOUSE
θ value	0.47712 (rank : 140)	NC score	0.155073 (rank : 121)
Query Neighborhood Hits	194	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

CYR61_MOUSE
θ value	0.62314 (rank : 141)	NC score	0.111118 (rank : 127)
Query Neighborhood Hits	194	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

DLL1_MOUSE
θ value	0.62314 (rank : 142)	NC score	0.047289 (rank : 178)
Query Neighborhood Hits	194	Target Neighborhood Hits	456	Shared Neighborhood Hits	71
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

MMP7_MOUSE
θ value	0.62314 (rank : 143)	NC score	0.061220 (rank : 162)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP10_MOUSE
θ value	0.813845 (rank : 144)	NC score	0.034760 (rank : 196)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	30
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP1_HUMAN
θ value	0.813845 (rank : 145)	NC score	0.032039 (rank : 203)
Query Neighborhood Hits	194	Target Neighborhood Hits	55	Shared Neighborhood Hits	26
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP20_MOUSE
θ value	0.813845 (rank : 146)	NC score	0.036048 (rank : 193)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP2_HUMAN
θ value	0.813845 (rank : 147)	NC score	0.047039 (rank : 179)
Query Neighborhood Hits	194	Target Neighborhood Hits	79	Shared Neighborhood Hits	35
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

NOV_MOUSE
θ value	0.813845 (rank : 148)	NC score	0.118976 (rank : 125)
Query Neighborhood Hits	194	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP2_HUMAN
θ value	0.813845 (rank : 149)	NC score	0.157311 (rank : 120)
Query Neighborhood Hits	194	Target Neighborhood Hits	126	Shared Neighborhood Hits	60
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

MMP12_HUMAN
θ value	1.06291 (rank : 150)	NC score	0.037512 (rank : 191)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	30
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

RSPO1_HUMAN
θ value	1.06291 (rank : 151)	NC score	0.104969 (rank : 130)
Query Neighborhood Hits	194	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

CTGF_HUMAN
θ value	1.38821 (rank : 152)	NC score	0.095431 (rank : 133)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

DLL1_HUMAN
θ value	1.38821 (rank : 153)	NC score	0.042206 (rank : 184)
Query Neighborhood Hits	194	Target Neighborhood Hits	455	Shared Neighborhood Hits	66
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

MMP1A_MOUSE
θ value	1.38821 (rank : 154)	NC score	0.037550 (rank : 190)
Query Neighborhood Hits	194	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP20_HUMAN
θ value	1.38821 (rank : 155)	NC score	0.034888 (rank : 195)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

RSPO2_HUMAN
θ value	1.38821 (rank : 156)	NC score	0.066440 (rank : 156)
Query Neighborhood Hits	194	Target Neighborhood Hits	90	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

CTGF_MOUSE
θ value	1.81305 (rank : 157)	NC score	0.100263 (rank : 132)
Query Neighborhood Hits	194	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

FBN2_HUMAN
θ value	1.81305 (rank : 158)	NC score	0.042183 (rank : 186)
Query Neighborhood Hits	194	Target Neighborhood Hits	560	Shared Neighborhood Hits	83
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

MMP2_MOUSE
θ value	1.81305 (rank : 159)	NC score	0.044848 (rank : 180)
Query Neighborhood Hits	194	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

SPON2_HUMAN
θ value	1.81305 (rank : 160)	NC score	0.094197 (rank : 136)
Query Neighborhood Hits	194	Target Neighborhood Hits	53	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

STAB2_HUMAN
θ value	1.81305 (rank : 161)	NC score	0.039712 (rank : 187)
Query Neighborhood Hits	194	Target Neighborhood Hits	534	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

WISP1_MOUSE
θ value	1.81305 (rank : 162)	NC score	0.140707 (rank : 122)
Query Neighborhood Hits	194	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

CCNF_MOUSE
θ value	2.36792 (rank : 163)	NC score	0.006637 (rank : 215)
Query Neighborhood Hits	194	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P51944, Q60797, Q60799	Gene names	Ccnf
Domain Architecture
Description	G2/mitotic-specific cyclin-F.

MMP14_MOUSE
θ value	2.36792 (rank : 164)	NC score	0.032953 (rank : 201)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	29
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

PARP8_MOUSE
θ value	2.36792 (rank : 165)	NC score	0.009410 (rank : 212)
Query Neighborhood Hits	194	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

UROL1_HUMAN
θ value	2.36792 (rank : 166)	NC score	0.011583 (rank : 210)
Query Neighborhood Hits	194	Target Neighborhood Hits	213	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DID0, Q5DIC9, Q6LA40, Q6LA41, Q8N216	Gene names	UMODL1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

CLK3_HUMAN
θ value	3.0926 (rank : 167)	NC score	-0.005335 (rank : 225)
Query Neighborhood Hits	194	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	3.0926 (rank : 168)	NC score	-0.005330 (rank : 224)
Query Neighborhood Hits	194	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

GRN_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.024240 (rank : 207)
Query Neighborhood Hits	194	Target Neighborhood Hits	268	Shared Neighborhood Hits	28
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

LTBP4_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.034122 (rank : 199)
Query Neighborhood Hits	194	Target Neighborhood Hits	607	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MMP14_HUMAN
θ value	3.0926 (rank : 171)	NC score	0.032142 (rank : 202)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP28_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.034393 (rank : 197)
Query Neighborhood Hits	194	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

NOTC1_MOUSE
θ value	3.0926 (rank : 173)	NC score	0.044686 (rank : 181)
Query Neighborhood Hits	194	Target Neighborhood Hits	916	Shared Neighborhood Hits	79
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

RS10_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.010318 (rank : 211)
Query Neighborhood Hits	194	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P46783	Gene names	RPS10
Domain Architecture
Description	40S ribosomal protein S10.

RSPO2_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.060346 (rank : 163)
Query Neighborhood Hits	194	Target Neighborhood Hits	88	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

SPON2_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.080060 (rank : 142)
Query Neighborhood Hits	194	Target Neighborhood Hits	42	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

TENX_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.063999 (rank : 159)
Query Neighborhood Hits	194	Target Neighborhood Hits	789	Shared Neighborhood Hits	90
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

ABCA2_HUMAN
θ value	4.03905 (rank : 178)	NC score	0.001588 (rank : 218)
Query Neighborhood Hits	194	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).

EXOS7_MOUSE
θ value	4.03905 (rank : 179)	NC score	0.007051 (rank : 214)
Query Neighborhood Hits	194	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0M0, Q9CT77	Gene names	Exosc7, Rrp42
Domain Architecture
Description	Exosome complex exonuclease RRP42 (EC 3.1.13.-) (Ribosomal RNA- processing protein 42) (Exosome component 7).

MMP12_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.036134 (rank : 192)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

MMP24_MOUSE
θ value	4.03905 (rank : 181)	NC score	0.034195 (rank : 198)
Query Neighborhood Hits	194	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

WISP3_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.118350 (rank : 126)
Query Neighborhood Hits	194	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

IGF1R_HUMAN
θ value	5.27518 (rank : 183)	NC score	-0.000891 (rank : 223)
Query Neighborhood Hits	194	Target Neighborhood Hits	977	Shared Neighborhood Hits	38
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

K1H8_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.001377 (rank : 219)
Query Neighborhood Hits	194	Target Neighborhood Hits	394	Shared Neighborhood Hits	7
SwissProt Accessions	O76015	Gene names	KRTHA8, HHA8, HKA8
Domain Architecture
Description	Keratin, type I cuticular Ha8 (Hair keratin, type I Ha8).

MK_HUMAN
θ value	5.27518 (rank : 185)	NC score	0.035137 (rank : 194)
Query Neighborhood Hits	194	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

MMP24_HUMAN
θ value	5.27518 (rank : 186)	NC score	0.031900 (rank : 204)
Query Neighborhood Hits	194	Target Neighborhood Hits	66	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP3_MOUSE
θ value	5.27518 (rank : 187)	NC score	0.030886 (rank : 205)
Query Neighborhood Hits	194	Target Neighborhood Hits	53	Shared Neighborhood Hits	26
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

PARP8_HUMAN
θ value	5.27518 (rank : 188)	NC score	0.008198 (rank : 213)
Query Neighborhood Hits	194	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

MMP10_HUMAN
θ value	6.88961 (rank : 189)	NC score	0.029077 (rank : 206)
Query Neighborhood Hits	194	Target Neighborhood Hits	50	Shared Neighborhood Hits	24
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP8_MOUSE
θ value	6.88961 (rank : 190)	NC score	0.033089 (rank : 200)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	29
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

PDE5A_MOUSE
θ value	6.88961 (rank : 191)	NC score	0.000490 (rank : 220)
Query Neighborhood Hits	194	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

RPGF6_HUMAN
θ value	6.88961 (rank : 192)	NC score	-0.000001 (rank : 221)
Query Neighborhood Hits	194	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RSPO4_MOUSE
θ value	6.88961 (rank : 193)	NC score	0.103637 (rank : 131)
Query Neighborhood Hits	194	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

DGKH_HUMAN
θ value	8.99809 (rank : 194)	NC score	-0.000023 (rank : 222)
Query Neighborhood Hits	194	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CO9_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.061458 (rank : 161)
Query Neighborhood Hits	194	Target Neighborhood Hits	147	Shared Neighborhood Hits	20
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO9_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.068953 (rank : 150)
Query Neighborhood Hits	194	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

COMP_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.051271 (rank : 174)
Query Neighborhood Hits	194	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

CRIM1_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.056286 (rank : 168)
Query Neighborhood Hits	194	Target Neighborhood Hits	362	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KR101_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.065302 (rank : 158)
Query Neighborhood Hits	194	Target Neighborhood Hits	261	Shared Neighborhood Hits	52
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR102_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.080894 (rank : 139)
Query Neighborhood Hits	194	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

KR104_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.093333 (rank : 137)
Query Neighborhood Hits	194	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR105_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.051484 (rank : 172)
Query Neighborhood Hits	194	Target Neighborhood Hits	271	Shared Neighborhood Hits	46
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR106_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.095234 (rank : 134)
Query Neighborhood Hits	194	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.077270 (rank : 143)
Query Neighborhood Hits	194	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR109_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.055139 (rank : 169)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	36
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR10B_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.056306 (rank : 167)
Query Neighborhood Hits	194	Target Neighborhood Hits	269	Shared Neighborhood Hits	47
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KR10C_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.058014 (rank : 165)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	43
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KR412_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.051370 (rank : 173)
Query Neighborhood Hits	194	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

KRA51_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.080422 (rank : 140)
Query Neighborhood Hits	194	Target Neighborhood Hits	288	Shared Neighborhood Hits	67
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.058809 (rank : 164)
Query Neighborhood Hits	194	Target Neighborhood Hits	236	Shared Neighborhood Hits	48
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA53_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.074764 (rank : 146)
Query Neighborhood Hits	194	Target Neighborhood Hits	331	Shared Neighborhood Hits	64
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA54_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.067319 (rank : 153)
Query Neighborhood Hits	194	Target Neighborhood Hits	270	Shared Neighborhood Hits	56
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA57_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.063618 (rank : 160)
Query Neighborhood Hits	194	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.073051 (rank : 147)
Query Neighborhood Hits	194	Target Neighborhood Hits	324	Shared Neighborhood Hits	62
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.052462 (rank : 171)
Query Neighborhood Hits	194	Target Neighborhood Hits	310	Shared Neighborhood Hits	54
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA92_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.068394 (rank : 152)
Query Neighborhood Hits	194	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.070487 (rank : 149)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

KRA98_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.074771 (rank : 145)
Query Neighborhood Hits	194	Target Neighborhood Hits	185	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

LRP1B_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.050899 (rank : 175)
Query Neighborhood Hits	194	Target Neighborhood Hits	602	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MEGF6_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.054472 (rank : 170)
Query Neighborhood Hits	194	Target Neighborhood Hits	671	Shared Neighborhood Hits	100
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

RSPO3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.076146 (rank : 144)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.070544 (rank : 148)
Query Neighborhood Hits	194	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.080354 (rank : 141)
Query Neighborhood Hits	194	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

WISP1_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.129772 (rank : 123)
Query Neighborhood Hits	194	Target Neighborhood Hits	121	Shared Neighborhood Hits	61
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

ZAN_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.066021 (rank : 157)
Query Neighborhood Hits	194	Target Neighborhood Hits	808	Shared Neighborhood Hits	91
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

ATS17_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	194	Target Neighborhood Hits	194	Shared Neighborhood Hits	194
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS19_MOUSE
NC score	0.987030 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	194	Target Neighborhood Hits	188	Shared Neighborhood Hits	149
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS19_HUMAN
NC score	0.984899 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	144
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS18_HUMAN
NC score	0.977287 (rank : 4)	θ value	1.41924e-154 (rank : 4)
Query Neighborhood Hits	194	Target Neighborhood Hits	169	Shared Neighborhood Hits	135
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS18_MOUSE
NC score	0.977065 (rank : 5)	θ value	9.19922e-154 (rank : 5)
Query Neighborhood Hits	194	Target Neighborhood Hits	163	Shared Neighborhood Hits	135
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS16_MOUSE
NC score	0.975645 (rank : 6)	θ value	1.98959e-140 (rank : 9)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_MOUSE
NC score	0.975123 (rank : 7)	θ value	6.18479e-142 (rank : 8)
Query Neighborhood Hits	194	Target Neighborhood Hits	220	Shared Neighborhood Hits	136
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS16_HUMAN
NC score	0.974874 (rank : 8)	θ value	4.73554e-142 (rank : 7)
Query Neighborhood Hits	194	Target Neighborhood Hits	208	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_HUMAN
NC score	0.974003 (rank : 9)	θ value	1.33145e-144 (rank : 6)
Query Neighborhood Hits	194	Target Neighborhood Hits	251	Shared Neighborhood Hits	136
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS7_HUMAN
NC score	0.972735 (rank : 10)	θ value	4.75757e-126 (rank : 12)
Query Neighborhood Hits	194	Target Neighborhood Hits	169	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS3_HUMAN
NC score	0.972020 (rank : 11)	θ value	3.65119e-118 (rank : 15)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	140
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS6_HUMAN
NC score	0.970284 (rank : 12)	θ value	2.15048e-102 (rank : 21)
Query Neighborhood Hits	194	Target Neighborhood Hits	141	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS2_HUMAN
NC score	0.969328 (rank : 13)	θ value	3.65119e-118 (rank : 14)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
NC score	0.968514 (rank : 14)	θ value	2.00348e-116 (rank : 16)
Query Neighborhood Hits	194	Target Neighborhood Hits	179	Shared Neighborhood Hits	133
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS20_HUMAN
NC score	0.966746 (rank : 15)	θ value	2.78914e-126 (rank : 11)
Query Neighborhood Hits	194	Target Neighborhood Hits	192	Shared Neighborhood Hits	144
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS15_HUMAN
NC score	0.966713 (rank : 16)	θ value	5.84277e-108 (rank : 19)
Query Neighborhood Hits	194	Target Neighborhood Hits	151	Shared Neighborhood Hits	133
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS20_MOUSE
NC score	0.965980 (rank : 17)	θ value	9.58617e-127 (rank : 10)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	139
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS9_HUMAN
NC score	0.965683 (rank : 18)	θ value	1.93603e-119 (rank : 13)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	140
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS1_MOUSE
NC score	0.965571 (rank : 19)	θ value	2.00813e-108 (rank : 18)
Query Neighborhood Hits	194	Target Neighborhood Hits	158	Shared Neighborhood Hits	132
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS1_HUMAN
NC score	0.964020 (rank : 20)	θ value	1.1019e-106 (rank : 20)
Query Neighborhood Hits	194	Target Neighborhood Hits	159	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS14_HUMAN
NC score	0.962045 (rank : 21)	θ value	6.6695e-112 (rank : 17)
Query Neighborhood Hits	194	Target Neighborhood Hits	382	Shared Neighborhood Hits	135
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS5_MOUSE
NC score	0.961523 (rank : 22)	θ value	7.91507e-97 (rank : 23)
Query Neighborhood Hits	194	Target Neighborhood Hits	147	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS8_HUMAN
NC score	0.959448 (rank : 23)	θ value	1.82896e-85 (rank : 27)
Query Neighborhood Hits	194	Target Neighborhood Hits	145	Shared Neighborhood Hits	119
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS5_HUMAN
NC score	0.959144 (rank : 24)	θ value	9.34977e-98 (rank : 22)
Query Neighborhood Hits	194	Target Neighborhood Hits	141	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS8_MOUSE
NC score	0.953494 (rank : 25)	θ value	9.7205e-79 (rank : 29)
Query Neighborhood Hits	194	Target Neighborhood Hits	139	Shared Neighborhood Hits	121
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS4_MOUSE
NC score	0.949305 (rank : 26)	θ value	1.07224e-85 (rank : 26)
Query Neighborhood Hits	194	Target Neighborhood Hits	145	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS4_HUMAN
NC score	0.947629 (rank : 27)	θ value	4.07447e-85 (rank : 28)
Query Neighborhood Hits	194	Target Neighborhood Hits	138	Shared Neighborhood Hits	112
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS13_HUMAN
NC score	0.941179 (rank : 28)	θ value	1.82472e-93 (rank : 24)
Query Neighborhood Hits	194	Target Neighborhood Hits	238	Shared Neighborhood Hits	137
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
NC score	0.938792 (rank : 29)	θ value	3.56116e-89 (rank : 25)
Query Neighborhood Hits	194	Target Neighborhood Hits	227	Shared Neighborhood Hits	139
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATL1_HUMAN
NC score	0.900141 (rank : 30)	θ value	6.55044e-59 (rank : 31)
Query Neighborhood Hits	194	Target Neighborhood Hits	93	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATL5_HUMAN
NC score	0.892562 (rank : 31)	θ value	6.17384e-33 (rank : 33)
Query Neighborhood Hits	194	Target Neighborhood Hits	103	Shared Neighborhood Hits	79
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATL1_MOUSE
NC score	0.891074 (rank : 32)	θ value	6.15952e-41 (rank : 32)
Query Neighborhood Hits	194	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL2_MOUSE
NC score	0.858886 (rank : 33)	θ value	2.34606e-32 (rank : 35)
Query Neighborhood Hits	194	Target Neighborhood Hits	137	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL2_HUMAN
NC score	0.858130 (rank : 34)	θ value	1.37539e-32 (rank : 34)
Query Neighborhood Hits	194	Target Neighborhood Hits	125	Shared Neighborhood Hits	89
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL3_HUMAN
NC score	0.762500 (rank : 35)	θ value	7.98882e-65 (rank : 30)
Query Neighborhood Hits	194	Target Neighborhood Hits	414	Shared Neighborhood Hits	97
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PROP_HUMAN
NC score	0.647001 (rank : 36)	θ value	3.18553e-13 (rank : 58)
Query Neighborhood Hits	194	Target Neighborhood Hits	126	Shared Neighborhood Hits	85
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
NC score	0.639190 (rank : 37)	θ value	2.52405e-10 (rank : 75)
Query Neighborhood Hits	194	Target Neighborhood Hits	165	Shared Neighborhood Hits	90
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

SPON1_HUMAN
NC score	0.598155 (rank : 38)	θ value	1.133e-10 (rank : 73)
Query Neighborhood Hits	194	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
NC score	0.597101 (rank : 39)	θ value	2.52405e-10 (rank : 76)
Query Neighborhood Hits	194	Target Neighborhood Hits	123	Shared Neighborhood Hits	96
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

CI094_HUMAN
NC score	0.587472 (rank : 40)	θ value	1.4233e-29 (rank : 36)
Query Neighborhood Hits	194	Target Neighborhood Hits	310	Shared Neighborhood Hits	77
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ADAM8_MOUSE
NC score	0.587467 (rank : 41)	θ value	2.77775e-25 (rank : 37)
Query Neighborhood Hits	194	Target Neighborhood Hits	326	Shared Neighborhood Hits	95
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

ADAM8_HUMAN
NC score	0.585859 (rank : 42)	θ value	1.09232e-21 (rank : 38)
Query Neighborhood Hits	194	Target Neighborhood Hits	327	Shared Neighborhood Hits	88
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

ADA19_MOUSE
NC score	0.579566 (rank : 43)	θ value	6.20254e-17 (rank : 43)
Query Neighborhood Hits	194	Target Neighborhood Hits	315	Shared Neighborhood Hits	93
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

ADA28_MOUSE
NC score	0.578707 (rank : 44)	θ value	1.38178e-16 (rank : 46)
Query Neighborhood Hits	194	Target Neighborhood Hits	241	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADA19_HUMAN
NC score	0.570229 (rank : 45)	θ value	4.91457e-14 (rank : 55)
Query Neighborhood Hits	194	Target Neighborhood Hits	381	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA28_HUMAN
NC score	0.566596 (rank : 46)	θ value	3.89403e-11 (rank : 69)
Query Neighborhood Hits	194	Target Neighborhood Hits	244	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

ADEC1_HUMAN
NC score	0.562614 (rank : 47)	θ value	7.34386e-10 (rank : 79)
Query Neighborhood Hits	194	Target Neighborhood Hits	80	Shared Neighborhood Hits	71
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA12_HUMAN
NC score	0.562470 (rank : 48)	θ value	2.69047e-20 (rank : 39)
Query Neighborhood Hits	194	Target Neighborhood Hits	224	Shared Neighborhood Hits	84
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA33_HUMAN
NC score	0.561655 (rank : 49)	θ value	7.84624e-12 (rank : 67)
Query Neighborhood Hits	194	Target Neighborhood Hits	264	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA12_MOUSE
NC score	0.553260 (rank : 50)	θ value	2.13179e-17 (rank : 42)
Query Neighborhood Hits	194	Target Neighborhood Hits	474	Shared Neighborhood Hits	88
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADAM7_HUMAN
NC score	0.546186 (rank : 51)	θ value	1.68911e-14 (rank : 54)
Query Neighborhood Hits	194	Target Neighborhood Hits	221	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

ADA15_HUMAN
NC score	0.542894 (rank : 52)	θ value	1.74391e-19 (rank : 40)
Query Neighborhood Hits	194	Target Neighborhood Hits	288	Shared Neighborhood Hits	90
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADAM7_MOUSE
NC score	0.542539 (rank : 53)	θ value	2.79066e-09 (rank : 86)
Query Neighborhood Hits	194	Target Neighborhood Hits	200	Shared Neighborhood Hits	84
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

ADAM9_MOUSE
NC score	0.542300 (rank : 54)	θ value	8.10077e-17 (rank : 45)
Query Neighborhood Hits	194	Target Neighborhood Hits	325	Shared Neighborhood Hits	90
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

ADAM9_HUMAN
NC score	0.533630 (rank : 55)	θ value	8.10077e-17 (rank : 44)
Query Neighborhood Hits	194	Target Neighborhood Hits	243	Shared Neighborhood Hits	86
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

ADA33_MOUSE
NC score	0.533529 (rank : 56)	θ value	8.11959e-09 (rank : 89)
Query Neighborhood Hits	194	Target Neighborhood Hits	231	Shared Neighborhood Hits	90
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA15_MOUSE
NC score	0.516782 (rank : 57)	θ value	1.24977e-17 (rank : 41)
Query Neighborhood Hits	194	Target Neighborhood Hits	324	Shared Neighborhood Hits	96
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADEC1_MOUSE
NC score	0.513427 (rank : 58)	θ value	3.08544e-08 (rank : 91)
Query Neighborhood Hits	194	Target Neighborhood Hits	85	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

THSD1_HUMAN
NC score	0.510946 (rank : 59)	θ value	3.19293e-05 (rank : 107)
Query Neighborhood Hits	194	Target Neighborhood Hits	136	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADM1B_MOUSE
NC score	0.509086 (rank : 60)	θ value	3.89403e-11 (rank : 70)
Query Neighborhood Hits	194	Target Neighborhood Hits	236	Shared Neighborhood Hits	89
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

ADA21_MOUSE
NC score	0.505082 (rank : 61)	θ value	8.95645e-16 (rank : 51)
Query Neighborhood Hits	194	Target Neighborhood Hits	172	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

ADM1A_MOUSE
NC score	0.499648 (rank : 62)	θ value	1.133e-10 (rank : 72)
Query Neighborhood Hits	194	Target Neighborhood Hits	230	Shared Neighborhood Hits	83
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

ADA22_HUMAN
NC score	0.498642 (rank : 63)	θ value	6.21693e-09 (rank : 87)
Query Neighborhood Hits	194	Target Neighborhood Hits	211	Shared Neighborhood Hits	87
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

ADA24_MOUSE
NC score	0.498560 (rank : 64)	θ value	1.63604e-09 (rank : 84)
Query Neighborhood Hits	194	Target Neighborhood Hits	230	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

ADA25_MOUSE
NC score	0.493369 (rank : 65)	θ value	9.90251e-15 (rank : 53)
Query Neighborhood Hits	194	Target Neighborhood Hits	213	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

ADA29_HUMAN
NC score	0.492072 (rank : 66)	θ value	7.34386e-10 (rank : 78)
Query Neighborhood Hits	194	Target Neighborhood Hits	247	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ADA21_HUMAN
NC score	0.489817 (rank : 67)	θ value	8.38298e-14 (rank : 56)
Query Neighborhood Hits	194	Target Neighborhood Hits	181	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

ADA22_MOUSE
NC score	0.487799 (rank : 68)	θ value	3.41135e-07 (rank : 94)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

ADA23_MOUSE
NC score	0.484488 (rank : 69)	θ value	0.000121331 (rank : 108)
Query Neighborhood Hits	194	Target Neighborhood Hits	245	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

UNC5A_MOUSE
NC score	0.481164 (rank : 70)	θ value	3.29651e-10 (rank : 77)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

AD26A_MOUSE
NC score	0.480868 (rank : 71)	θ value	0.000602161 (rank : 110)
Query Neighborhood Hits	194	Target Neighborhood Hits	165	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

BAI1_MOUSE
NC score	0.479416 (rank : 72)	θ value	5.25075e-16 (rank : 49)
Query Neighborhood Hits	194	Target Neighborhood Hits	340	Shared Neighborhood Hits	91
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI2_HUMAN
NC score	0.479030 (rank : 73)	θ value	4.16044e-13 (rank : 60)
Query Neighborhood Hits	194	Target Neighborhood Hits	332	Shared Neighborhood Hits	96
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
NC score	0.478409 (rank : 74)	θ value	2.35696e-16 (rank : 47)
Query Neighborhood Hits	194	Target Neighborhood Hits	246	Shared Neighborhood Hits	90
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI1_HUMAN
NC score	0.477542 (rank : 75)	θ value	4.02038e-16 (rank : 48)
Query Neighborhood Hits	194	Target Neighborhood Hits	375	Shared Neighborhood Hits	94
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI3_MOUSE
NC score	0.477485 (rank : 76)	θ value	2.60593e-15 (rank : 52)
Query Neighborhood Hits	194	Target Neighborhood Hits	250	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ADA23_HUMAN
NC score	0.477372 (rank : 77)	θ value	0.000158464 (rank : 109)
Query Neighborhood Hits	194	Target Neighborhood Hits	235	Shared Neighborhood Hits	86
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

THSD1_MOUSE
NC score	0.477010 (rank : 78)	θ value	0.000602161 (rank : 111)
Query Neighborhood Hits	194	Target Neighborhood Hits	153	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

BAI2_MOUSE
NC score	0.476237 (rank : 79)	θ value	3.18553e-13 (rank : 57)
Query Neighborhood Hits	194	Target Neighborhood Hits	323	Shared Neighborhood Hits	95
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

TSP1_HUMAN
NC score	0.473110 (rank : 80)	θ value	1.02475e-11 (rank : 68)
Query Neighborhood Hits	194	Target Neighborhood Hits	389	Shared Neighborhood Hits	105
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
NC score	0.472944 (rank : 81)	θ value	6.00763e-12 (rank : 65)
Query Neighborhood Hits	194	Target Neighborhood Hits	396	Shared Neighborhood Hits	107
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_MOUSE
NC score	0.470454 (rank : 82)	θ value	6.00763e-12 (rank : 66)
Query Neighborhood Hits	194	Target Neighborhood Hits	352	Shared Neighborhood Hits	100
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

UNC5B_MOUSE
NC score	0.469646 (rank : 83)	θ value	8.11959e-09 (rank : 90)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

ADA11_MOUSE
NC score	0.468563 (rank : 84)	θ value	2.52405e-10 (rank : 74)
Query Neighborhood Hits	194	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

UNC5B_HUMAN
NC score	0.467363 (rank : 85)	θ value	6.21693e-09 (rank : 88)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

TSP2_HUMAN
NC score	0.467158 (rank : 86)	θ value	3.89403e-11 (rank : 71)
Query Neighborhood Hits	194	Target Neighborhood Hits	359	Shared Neighborhood Hits	104
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

UNC5C_MOUSE
NC score	0.454461 (rank : 87)	θ value	9.59137e-10 (rank : 82)
Query Neighborhood Hits	194	Target Neighborhood Hits	225	Shared Neighborhood Hits	79
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.453965 (rank : 88)	θ value	9.59137e-10 (rank : 81)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	79
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

ADA20_HUMAN
NC score	0.448693 (rank : 89)	θ value	9.59137e-10 (rank : 80)
Query Neighborhood Hits	194	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

UNC5D_HUMAN
NC score	0.446276 (rank : 90)	θ value	9.59137e-10 (rank : 83)
Query Neighborhood Hits	194	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA11_HUMAN
NC score	0.444388 (rank : 91)	θ value	9.92553e-07 (rank : 97)
Query Neighborhood Hits	194	Target Neighborhood Hits	259	Shared Neighborhood Hits	86
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADAM2_MOUSE
NC score	0.444372 (rank : 92)	θ value	2.88788e-06 (rank : 101)
Query Neighborhood Hits	194	Target Neighborhood Hits	209	Shared Neighborhood Hits	84
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

UNC5D_MOUSE
NC score	0.442563 (rank : 93)	θ value	2.13673e-09 (rank : 85)
Query Neighborhood Hits	194	Target Neighborhood Hits	268	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

ADA32_MOUSE
NC score	0.439638 (rank : 94)	θ value	1.29631e-06 (rank : 98)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

SEM5A_HUMAN
NC score	0.438563 (rank : 95)	θ value	1.58096e-12 (rank : 63)
Query Neighborhood Hits	194	Target Neighborhood Hits	177	Shared Neighborhood Hits	90
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ADA32_HUMAN
NC score	0.437540 (rank : 96)	θ value	0.00102713 (rank : 112)
Query Neighborhood Hits	194	Target Neighborhood Hits	216	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

SSPO_MOUSE
NC score	0.432793 (rank : 97)	θ value	5.25075e-16 (rank : 50)
Query Neighborhood Hits	194	Target Neighborhood Hits	800	Shared Neighborhood Hits	146
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SEM5A_MOUSE
NC score	0.428968 (rank : 98)	θ value	4.59992e-12 (rank : 64)
Query Neighborhood Hits	194	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5B_MOUSE
NC score	0.427975 (rank : 99)	θ value	7.09661e-13 (rank : 62)
Query Neighborhood Hits	194	Target Neighborhood Hits	190	Shared Neighborhood Hits	92
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SEM5B_HUMAN
NC score	0.425797 (rank : 100)	θ value	3.18553e-13 (rank : 59)
Query Neighborhood Hits	194	Target Neighborhood Hits	178	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

CO8A_HUMAN
NC score	0.424181 (rank : 101)	θ value	2.21117e-06 (rank : 99)
Query Neighborhood Hits	194	Target Neighborhood Hits	200	Shared Neighborhood Hits	72
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ADA18_MOUSE
NC score	0.421275 (rank : 102)	θ value	3.19293e-05 (rank : 105)
Query Neighborhood Hits	194	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

CO6_HUMAN
NC score	0.419968 (rank : 103)	θ value	4.45536e-07 (rank : 96)
Query Neighborhood Hits	194	Target Neighborhood Hits	331	Shared Neighborhood Hits	89
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CO8A_MOUSE
NC score	0.417977 (rank : 104)	θ value	4.0297e-08 (rank : 93)
Query Neighborhood Hits	194	Target Neighborhood Hits	182	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

ADAM2_HUMAN
NC score	0.408728 (rank : 105)	θ value	0.0252991 (rank : 120)
Query Neighborhood Hits	194	Target Neighborhood Hits	175	Shared Neighborhood Hits	75
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

ADA17_MOUSE
NC score	0.404709 (rank : 106)	θ value	4.0297e-08 (rank : 92)
Query Neighborhood Hits	194	Target Neighborhood Hits	201	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

CILP2_HUMAN
NC score	0.400899 (rank : 107)	θ value	3.19293e-05 (rank : 106)
Query Neighborhood Hits	194	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CO8B_MOUSE
NC score	0.400338 (rank : 108)	θ value	2.21117e-06 (rank : 100)
Query Neighborhood Hits	194	Target Neighborhood Hits	224	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADA18_HUMAN
NC score	0.399129 (rank : 109)	θ value	6.43352e-06 (rank : 102)
Query Neighborhood Hits	194	Target Neighborhood Hits	184	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

UNC5A_HUMAN
NC score	0.392798 (rank : 110)	θ value	3.41135e-07 (rank : 95)
Query Neighborhood Hits	194	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ADA17_HUMAN
NC score	0.391064 (rank : 111)	θ value	1.09739e-05 (rank : 103)
Query Neighborhood Hits	194	Target Neighborhood Hits	223	Shared Neighborhood Hits	90
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ADA30_HUMAN
NC score	0.390429 (rank : 112)	θ value	0.00175202 (rank : 114)
Query Neighborhood Hits	194	Target Neighborhood Hits	391	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

ADA10_MOUSE
NC score	0.382989 (rank : 113)	θ value	0.163984 (rank : 127)
Query Neighborhood Hits	194	Target Neighborhood Hits	194	Shared Neighborhood Hits	77
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

ADA10_HUMAN
NC score	0.381463 (rank : 114)	θ value	0.163984 (rank : 126)
Query Neighborhood Hits	194	Target Neighborhood Hits	189	Shared Neighborhood Hits	76
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

CO7_HUMAN
NC score	0.367863 (rank : 115)	θ value	0.00134147 (rank : 113)
Query Neighborhood Hits	194	Target Neighborhood Hits	278	Shared Neighborhood Hits	79
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

CO8B_HUMAN
NC score	0.360785 (rank : 116)	θ value	0.0193708 (rank : 119)
Query Neighborhood Hits	194	Target Neighborhood Hits	199	Shared Neighborhood Hits	72
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CILP1_MOUSE
NC score	0.296989 (rank : 117)	θ value	0.0113563 (rank : 117)
Query Neighborhood Hits	194	Target Neighborhood Hits	282	Shared Neighborhood Hits	78
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

HMCN1_HUMAN
NC score	0.293605 (rank : 118)	θ value	4.16044e-13 (rank : 61)
Query Neighborhood Hits	194	Target Neighborhood Hits	983	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

CILP1_HUMAN
NC score	0.293470 (rank : 119)	θ value	0.00298849 (rank : 115)
Query Neighborhood Hits	194	Target Neighborhood Hits	266	Shared Neighborhood Hits	79
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

WISP2_HUMAN
NC score	0.157311 (rank : 120)	θ value	0.813845 (rank : 149)
Query Neighborhood Hits	194	Target Neighborhood Hits	126	Shared Neighborhood Hits	60
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
NC score	0.155073 (rank : 121)	θ value	0.47712 (rank : 140)
Query Neighborhood Hits	194	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP1_MOUSE
NC score	0.140707 (rank : 122)	θ value	1.81305 (rank : 162)
Query Neighborhood Hits	194	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
NC score	0.129772 (rank : 123)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	194	Target Neighborhood Hits	121	Shared Neighborhood Hits	61
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

CYR61_HUMAN
NC score	0.126727 (rank : 124)	θ value	0.365318 (rank : 135)
Query Neighborhood Hits	194	Target Neighborhood Hits	159	Shared Neighborhood Hits	72
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

NOV_MOUSE
NC score	0.118976 (rank : 125)	θ value	0.813845 (rank : 148)
Query Neighborhood Hits	194	Target Neighborhood Hits	130	Shared Neighborhood Hits	57
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP3_HUMAN
NC score	0.118350 (rank : 126)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	194	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

CYR61_MOUSE
NC score	0.111118 (rank : 127)	θ value	0.62314 (rank : 141)
Query Neighborhood Hits	194	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

NOV_HUMAN
NC score	0.107329 (rank : 128)	θ value	0.279714 (rank : 133)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

FRAS1_MOUSE
NC score	0.106544 (rank : 129)	θ value	0.279714 (rank : 131)
Query Neighborhood Hits	194	Target Neighborhood Hits	747	Shared Neighborhood Hits	102
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO1_HUMAN
NC score	0.104969 (rank : 130)	θ value	1.06291 (rank : 151)
Query Neighborhood Hits	194	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO4_MOUSE
NC score	0.103637 (rank : 131)	θ value	6.88961 (rank : 193)
Query Neighborhood Hits	194	Target Neighborhood Hits	110	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

CTGF_MOUSE
NC score	0.100263 (rank : 132)	θ value	1.81305 (rank : 157)
Query Neighborhood Hits	194	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

CTGF_HUMAN
NC score	0.095431 (rank : 133)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	52
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

KR106_HUMAN
NC score	0.095234 (rank : 134)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	194	Target Neighborhood Hits	347	Shared Neighborhood Hits	68
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

RSPO1_MOUSE
NC score	0.095073 (rank : 135)	θ value	0.0961366 (rank : 125)
Query Neighborhood Hits	194	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

SPON2_HUMAN
NC score	0.094197 (rank : 136)	θ value	1.81305 (rank : 160)
Query Neighborhood Hits	194	Target Neighborhood Hits	53	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

KR104_HUMAN
NC score	0.093333 (rank : 137)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	194	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

FRAS1_HUMAN
NC score	0.092939 (rank : 138)	θ value	0.279714 (rank : 130)
Query Neighborhood Hits	194	Target Neighborhood Hits	759	Shared Neighborhood Hits	99
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR102_HUMAN
NC score	0.080894 (rank : 139)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	194	Target Neighborhood Hits	264	Shared Neighborhood Hits	51
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

KRA51_HUMAN
NC score	0.080422 (rank : 140)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	194	Target Neighborhood Hits	288	Shared Neighborhood Hits	67
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

RSPO4_HUMAN
NC score	0.080354 (rank : 141)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	194	Target Neighborhood Hits	110	Shared Neighborhood Hits	43
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

SPON2_MOUSE
NC score	0.080060 (rank : 142)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	194	Target Neighborhood Hits	42	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

KR107_HUMAN
NC score	0.077270 (rank : 143)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	194	Target Neighborhood Hits	330	Shared Neighborhood Hits	56
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

RSPO3_HUMAN
NC score	0.076146 (rank : 144)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	194	Target Neighborhood Hits	128	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

KRA98_HUMAN
NC score	0.074771 (rank : 145)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	194	Target Neighborhood Hits	185	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

KRA53_HUMAN
NC score	0.074764 (rank : 146)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	194	Target Neighborhood Hits	331	Shared Neighborhood Hits	64
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA58_HUMAN
NC score	0.073051 (rank : 147)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	194	Target Neighborhood Hits	324	Shared Neighborhood Hits	62
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

RSPO3_MOUSE
NC score	0.070544 (rank : 148)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	194	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

KRA93_HUMAN
NC score	0.070487 (rank : 149)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	194	Target Neighborhood Hits	203	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

CO9_MOUSE
NC score	0.068953 (rank : 150)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	194	Target Neighborhood Hits	153	Shared Neighborhood Hits	27
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

NFX1_HUMAN
NC score	0.068408 (rank : 151)	θ value	0.0431538 (rank : 122)
Query Neighborhood Hits	194	Target Neighborhood Hits	405	Shared Neighborhood Hits	41
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

KRA92_HUMAN
NC score	0.068394 (rank : 152)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	194	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA54_HUMAN
NC score	0.067319 (rank : 153)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	194	Target Neighborhood Hits	270	Shared Neighborhood Hits	56
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

PCSK5_MOUSE
NC score	0.067166 (rank : 154)	θ value	0.0431538 (rank : 123)
Query Neighborhood Hits	194	Target Neighborhood Hits	613	Shared Neighborhood Hits	72
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

MMP26_HUMAN
NC score	0.067122 (rank : 155)	θ value	0.0961366 (rank : 124)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

RSPO2_HUMAN
NC score	0.066440 (rank : 156)	θ value	1.38821 (rank : 156)
Query Neighborhood Hits	194	Target Neighborhood Hits	90	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

ZAN_MOUSE
NC score	0.066021 (rank : 157)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	194	Target Neighborhood Hits	808	Shared Neighborhood Hits	91
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KR101_HUMAN
NC score	0.065302 (rank : 158)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	194	Target Neighborhood Hits	261	Shared Neighborhood Hits	52
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

TENX_HUMAN
NC score	0.063999 (rank : 159)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	194	Target Neighborhood Hits	789	Shared Neighborhood Hits	90
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

KRA57_HUMAN
NC score	0.063618 (rank : 160)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	194	Target Neighborhood Hits	269	Shared Neighborhood Hits	53
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

CO9_HUMAN
NC score	0.061458 (rank : 161)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	194	Target Neighborhood Hits	147	Shared Neighborhood Hits	20
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

MMP7_MOUSE
NC score	0.061220 (rank : 162)	θ value	0.62314 (rank : 143)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	42
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

RSPO2_MOUSE
NC score	0.060346 (rank : 163)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	194	Target Neighborhood Hits	88	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

KRA52_HUMAN
NC score	0.058809 (rank : 164)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	194	Target Neighborhood Hits	236	Shared Neighborhood Hits	48
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KR10C_HUMAN
NC score	0.058014 (rank : 165)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	194	Target Neighborhood Hits	219	Shared Neighborhood Hits	43
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

PCSK6_HUMAN
NC score	0.056429 (rank : 166)	θ value	1.87187e-05 (rank : 104)
Query Neighborhood Hits	194	Target Neighborhood Hits	298	Shared Neighborhood Hits	33
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

KR10B_HUMAN
NC score	0.056306 (rank : 167)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	194	Target Neighborhood Hits	269	Shared Neighborhood Hits	47
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

CRIM1_HUMAN
NC score	0.056286 (rank : 168)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	194	Target Neighborhood Hits	362	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KR109_HUMAN
NC score	0.055139 (rank : 169)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	194	Target Neighborhood Hits	226	Shared Neighborhood Hits	36
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

MEGF6_HUMAN
NC score	0.054472 (rank : 170)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	194	Target Neighborhood Hits	671	Shared Neighborhood Hits	100
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

KRA59_HUMAN
NC score	0.052462 (rank : 171)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	194	Target Neighborhood Hits	310	Shared Neighborhood Hits	54
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KR105_HUMAN
NC score	0.051484 (rank : 172)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	194	Target Neighborhood Hits	271	Shared Neighborhood Hits	46
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR412_HUMAN
NC score	0.051370 (rank : 173)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	194	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

COMP_HUMAN
NC score	0.051271 (rank : 174)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	194	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

LRP1B_HUMAN
NC score	0.050899 (rank : 175)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	194	Target Neighborhood Hits	602	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MK_MOUSE
NC score	0.050605 (rank : 176)	θ value	0.47712 (rank : 137)
Query Neighborhood Hits	194	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P12025	Gene names	Mdk, Mk
Domain Architecture
Description	Midkine precursor (MK) (Retinoic acid-induced differentiation factor).

PCSK5_HUMAN
NC score	0.050300 (rank : 177)	θ value	0.0330416 (rank : 121)
Query Neighborhood Hits	194	Target Neighborhood Hits	291	Shared Neighborhood Hits	38
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

DLL1_MOUSE
NC score	0.047289 (rank : 178)	θ value	0.62314 (rank : 142)
Query Neighborhood Hits	194	Target Neighborhood Hits	456	Shared Neighborhood Hits	71
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

MMP2_HUMAN
NC score	0.047039 (rank : 179)	θ value	0.813845 (rank : 147)
Query Neighborhood Hits	194	Target Neighborhood Hits	79	Shared Neighborhood Hits	35
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP2_MOUSE
NC score	0.044848 (rank : 180)	θ value	1.81305 (rank : 159)
Query Neighborhood Hits	194	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

NOTC1_MOUSE
NC score	0.044686 (rank : 181)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	194	Target Neighborhood Hits	916	Shared Neighborhood Hits	79
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

MMP13_MOUSE
NC score	0.043449 (rank : 182)	θ value	0.163984 (rank : 128)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

ALK1_MOUSE
NC score	0.042370 (rank : 183)	θ value	0.00509761 (rank : 116)
Query Neighborhood Hits	194	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	P97430, O09081, O09082	Gene names	Slpi
Domain Architecture
Description	Antileukoproteinase 1 precursor (ALP) (Secretory leukocyte protease inhibitor).

DLL1_HUMAN
NC score	0.042206 (rank : 184)	θ value	1.38821 (rank : 153)
Query Neighborhood Hits	194	Target Neighborhood Hits	455	Shared Neighborhood Hits	66
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

MMP1B_MOUSE
NC score	0.042204 (rank : 185)	θ value	0.365318 (rank : 136)
Query Neighborhood Hits	194	Target Neighborhood Hits	64	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

FBN2_HUMAN
NC score	0.042183 (rank : 186)	θ value	1.81305 (rank : 158)
Query Neighborhood Hits	194	Target Neighborhood Hits	560	Shared Neighborhood Hits	83
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

STAB2_HUMAN
NC score	0.039712 (rank : 187)	θ value	1.81305 (rank : 161)
Query Neighborhood Hits	194	Target Neighborhood Hits	534	Shared Neighborhood Hits	65
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

MMP13_HUMAN
NC score	0.039661 (rank : 188)	θ value	0.47712 (rank : 138)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	30
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP7_HUMAN
NC score	0.038840 (rank : 189)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	194	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP1A_MOUSE
NC score	0.037550 (rank : 190)	θ value	1.38821 (rank : 154)
Query Neighborhood Hits	194	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP12_HUMAN
NC score	0.037512 (rank : 191)	θ value	1.06291 (rank : 150)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	30
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

MMP12_MOUSE
NC score	0.036134 (rank : 192)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

MMP20_MOUSE
NC score	0.036048 (rank : 193)	θ value	0.813845 (rank : 146)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MK_HUMAN
NC score	0.035137 (rank : 194)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	194	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	P21741	Gene names	MDK, MK1, NEGF2
Domain Architecture
Description	Midkine precursor (MK) (Neurite outgrowth-promoting protein) (Midgestation and kidney protein) (Amphiregulin-associated protein) (ARAP) (Neurite outgrowth-promoting factor 2).

MMP20_HUMAN
NC score	0.034888 (rank : 195)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	194	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP10_MOUSE
NC score	0.034760 (rank : 196)	θ value	0.813845 (rank : 144)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	30
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP28_HUMAN
NC score	0.034393 (rank : 197)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	194	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

MMP24_MOUSE
NC score	0.034195 (rank : 198)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	194	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

LTBP4_MOUSE
NC score	0.034122 (rank : 199)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	194	Target Neighborhood Hits	607	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MMP8_MOUSE
NC score	0.033089 (rank : 200)	θ value	6.88961 (rank : 190)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	29
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP14_MOUSE
NC score	0.032953 (rank : 201)	θ value	2.36792 (rank : 164)
Query Neighborhood Hits	194	Target Neighborhood Hits	57	Shared Neighborhood Hits	29
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP14_HUMAN
NC score	0.032142 (rank : 202)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	194	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP1_HUMAN
NC score	0.032039 (rank : 203)	θ value	0.813845 (rank : 145)
Query Neighborhood Hits	194	Target Neighborhood Hits	55	Shared Neighborhood Hits	26
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP24_HUMAN
NC score	0.031900 (rank : 204)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	194	Target Neighborhood Hits	66	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP3_MOUSE
NC score	0.030886 (rank : 205)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	194	Target Neighborhood Hits	53	Shared Neighborhood Hits	26
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP10_HUMAN
NC score	0.029077 (rank : 206)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	194	Target Neighborhood Hits	50	Shared Neighborhood Hits	24
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

GRN_HUMAN
NC score	0.024240 (rank : 207)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	194	Target Neighborhood Hits	268	Shared Neighborhood Hits	28
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

LAMC1_MOUSE
NC score	0.021370 (rank : 208)	θ value	0.0113563 (rank : 118)
Query Neighborhood Hits	194	Target Neighborhood Hits	856	Shared Neighborhood Hits	41
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMC1_HUMAN
NC score	0.019392 (rank : 209)	θ value	0.279714 (rank : 132)
Query Neighborhood Hits	194	Target Neighborhood Hits	922	Shared Neighborhood Hits	44
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

UROL1_HUMAN
NC score	0.011583 (rank : 210)	θ value	2.36792 (rank : 166)
Query Neighborhood Hits	194	Target Neighborhood Hits	213	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DID0, Q5DIC9, Q6LA40, Q6LA41, Q8N216	Gene names	UMODL1
Domain Architecture	No domain graphic available
Description	Uromodulin-like 1 precursor (Olfactorin).

RS10_HUMAN
NC score	0.010318 (rank : 211)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	194	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P46783	Gene names	RPS10
Domain Architecture
Description	40S ribosomal protein S10.

PARP8_MOUSE
NC score	0.009410 (rank : 212)	θ value	2.36792 (rank : 165)
Query Neighborhood Hits	194	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_HUMAN
NC score	0.008198 (rank : 213)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	194	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

EXOS7_MOUSE
NC score	0.007051 (rank : 214)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	194	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0M0, Q9CT77	Gene names	Exosc7, Rrp42
Domain Architecture
Description	Exosome complex exonuclease RRP42 (EC 3.1.13.-) (Ribosomal RNA- processing protein 42) (Exosome component 7).

CCNF_MOUSE
NC score	0.006637 (rank : 215)	θ value	2.36792 (rank : 163)
Query Neighborhood Hits	194	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P51944, Q60797, Q60799	Gene names	Ccnf
Domain Architecture
Description	G2/mitotic-specific cyclin-F.

APOA_HUMAN
NC score	0.004198 (rank : 216)	θ value	0.279714 (rank : 129)
Query Neighborhood Hits	194	Target Neighborhood Hits	221	Shared Neighborhood Hits	7
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

BRWD1_MOUSE
NC score	0.002697 (rank : 217)	θ value	0.365318 (rank : 134)
Query Neighborhood Hits	194	Target Neighborhood Hits	478	Shared Neighborhood Hits	3
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

ABCA2_HUMAN
NC score	0.001588 (rank : 218)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	194	Target Neighborhood Hits	143	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).

K1H8_HUMAN
NC score	0.001377 (rank : 219)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	194	Target Neighborhood Hits	394	Shared Neighborhood Hits	7
SwissProt Accessions	O76015	Gene names	KRTHA8, HHA8, HKA8
Domain Architecture
Description	Keratin, type I cuticular Ha8 (Hair keratin, type I Ha8).

PDE5A_MOUSE
NC score	0.000490 (rank : 220)	θ value	6.88961 (rank : 191)
Query Neighborhood Hits	194	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

RPGF6_HUMAN
NC score	-0.000001 (rank : 221)	θ value	6.88961 (rank : 192)
Query Neighborhood Hits	194	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

DGKH_HUMAN
NC score	-0.000023 (rank : 222)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	194	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

IGF1R_HUMAN
NC score	-0.000891 (rank : 223)	θ value	5.27518 (rank : 183)
Query Neighborhood Hits	194	Target Neighborhood Hits	977	Shared Neighborhood Hits	38
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

CLK3_MOUSE
NC score	-0.005330 (rank : 224)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	194	Target Neighborhood Hits	761	Shared Neighborhood Hits	4
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_HUMAN
NC score	-0.005335 (rank : 225)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	194	Target Neighborhood Hits	748	Shared Neighborhood Hits	4
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).