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Network neighborhood for query Sequence : RSPO2_HUMAN

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RSPO2_HUMAN
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RSPO2_HUMAN
θ value	1.1664e-140 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
θ value	3.88293e-136 (rank : 2)	NC score	0.997717 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	1.97229e-55 (rank : 3)	NC score	0.945718 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	1.66964e-54 (rank : 4)	NC score	0.947329 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	64
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	1.01294e-51 (rank : 5)	NC score	0.927139 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO1_HUMAN
θ value	2.25659e-51 (rank : 6)	NC score	0.934779 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO4_MOUSE
θ value	8.57503e-51 (rank : 7)	NC score	0.925272 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

RSPO1_MOUSE
θ value	2.1121e-49 (rank : 8)	NC score	0.937904 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

FRAS1_MOUSE
θ value	8.11959e-09 (rank : 9)	NC score	0.273019 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	747	Shared Neighborhood Hits	74
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

PCSK5_MOUSE
θ value	1.38499e-08 (rank : 10)	NC score	0.312636 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	613	Shared Neighborhood Hits	69
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FRAS1_HUMAN
θ value	1.53129e-07 (rank : 11)	NC score	0.269487 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	759	Shared Neighborhood Hits	75
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

PCSK5_HUMAN
θ value	1.99992e-07 (rank : 12)	NC score	0.313270 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK6_HUMAN
θ value	9.92553e-07 (rank : 13)	NC score	0.317999 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	56
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

SPON1_MOUSE
θ value	3.19293e-05 (rank : 14)	NC score	0.253031 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

SPON1_HUMAN
θ value	5.44631e-05 (rank : 15)	NC score	0.252040 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON2_MOUSE
θ value	0.00020696 (rank : 16)	NC score	0.308550 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

SPON2_HUMAN
θ value	0.00035302 (rank : 17)	NC score	0.311742 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

INSR_MOUSE
θ value	0.000786445 (rank : 18)	NC score	0.077584 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	968	Shared Neighborhood Hits	39
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IGF1R_HUMAN
θ value	0.00102713 (rank : 19)	NC score	0.080613 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	977	Shared Neighborhood Hits	42
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	0.00228821 (rank : 20)	NC score	0.082359 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSR_HUMAN
θ value	0.00298849 (rank : 21)	NC score	0.075468 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	963	Shared Neighborhood Hits	38
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

SSPO_MOUSE
θ value	0.00298849 (rank : 22)	NC score	0.152836 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	800	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

LTBP4_MOUSE
θ value	0.00390308 (rank : 23)	NC score	0.099495 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	607	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MEGF6_HUMAN
θ value	0.00869519 (rank : 24)	NC score	0.119218 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	671	Shared Neighborhood Hits	61
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

PROP_MOUSE
θ value	0.0113563 (rank : 25)	NC score	0.148945 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

FURIN_HUMAN
θ value	0.0148317 (rank : 26)	NC score	0.176466 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	52	Shared Neighborhood Hits	20
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

INSRR_HUMAN
θ value	0.0193708 (rank : 27)	NC score	0.082221 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	950	Shared Neighborhood Hits	41
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

SREC_HUMAN
θ value	0.0193708 (rank : 28)	NC score	0.119426 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	645	Shared Neighborhood Hits	58
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

MEGF9_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.105829 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

FURIN_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.171584 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

HMCN1_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.083716 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	983	Shared Neighborhood Hits	70
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

LAMA1_HUMAN
θ value	0.279714 (rank : 32)	NC score	0.088635 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	804	Shared Neighborhood Hits	49
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

NOTC1_HUMAN
θ value	0.279714 (rank : 33)	NC score	0.078455 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	906	Shared Neighborhood Hits	56
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

INSRR_MOUSE
θ value	0.365318 (rank : 34)	NC score	0.079391 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	961	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PGBM_MOUSE
θ value	0.365318 (rank : 35)	NC score	0.059912 (rank : 176)
Query Neighborhood Hits	90	Target Neighborhood Hits	1073	Shared Neighborhood Hits	50
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FBN1_MOUSE
θ value	0.62314 (rank : 36)	NC score	0.090492 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	563	Shared Neighborhood Hits	50
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

LHX4_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.024151 (rank : 242)
Query Neighborhood Hits	90	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX4_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.024158 (rank : 241)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	7
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

NID2_HUMAN
θ value	0.62314 (rank : 39)	NC score	0.055743 (rank : 194)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	39
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NOTC1_MOUSE
θ value	0.62314 (rank : 40)	NC score	0.077985 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	916	Shared Neighborhood Hits	51
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

TNR6B_HUMAN
θ value	0.62314 (rank : 41)	NC score	0.122720 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

CRIM1_HUMAN
θ value	0.813845 (rank : 42)	NC score	0.116358 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

FBN1_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.091077 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	557	Shared Neighborhood Hits	54
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

LAMA5_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.082528 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	828	Shared Neighborhood Hits	47
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMA2_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.083526 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	1092	Shared Neighborhood Hits	51
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA2_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.080422 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	1198	Shared Neighborhood Hits	51
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA3_MOUSE
θ value	1.06291 (rank : 47)	NC score	0.073560 (rank : 108)
Query Neighborhood Hits	90	Target Neighborhood Hits	859	Shared Neighborhood Hits	47
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

ATS17_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.066440 (rank : 136)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

BAI1_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.086187 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	39
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

SCUB3_MOUSE
θ value	1.38821 (rank : 50)	NC score	0.087306 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	442	Shared Neighborhood Hits	44
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

ATS13_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.053345 (rank : 208)
Query Neighborhood Hits	90	Target Neighborhood Hits	238	Shared Neighborhood Hits	29
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

MEGF9_HUMAN
θ value	2.36792 (rank : 52)	NC score	0.100279 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	557	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

ATS20_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.066788 (rank : 134)
Query Neighborhood Hits	90	Target Neighborhood Hits	192	Shared Neighborhood Hits	38
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS3_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.049016 (rank : 236)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	31
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

FBN2_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.081967 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	560	Shared Neighborhood Hits	52
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

LAMC2_HUMAN
θ value	3.0926 (rank : 56)	NC score	0.067315 (rank : 133)
Query Neighborhood Hits	90	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

LTBP2_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.079302 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	552	Shared Neighborhood Hits	49
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

ATS20_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.073216 (rank : 109)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

BAI2_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.094403 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	4.03905 (rank : 60)	NC score	0.093352 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	323	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

LTB1L_MOUSE
θ value	4.03905 (rank : 61)	NC score	0.072687 (rank : 113)
Query Neighborhood Hits	90	Target Neighborhood Hits	514	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.075493 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

SREC2_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.119383 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	645	Shared Neighborhood Hits	57
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TNR5_MOUSE
θ value	4.03905 (rank : 64)	NC score	0.087464 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

ATS13_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.051284 (rank : 223)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS16_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.063254 (rank : 152)
Query Neighborhood Hits	90	Target Neighborhood Hits	208	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS7_HUMAN
θ value	5.27518 (rank : 67)	NC score	0.039868 (rank : 238)
Query Neighborhood Hits	90	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

FAM5A_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.019505 (rank : 247)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O60477, Q6IPV6, Q6P1A0, Q8WU22	Gene names	FAM5A, DBC1, DBCCR1
Domain Architecture	No domain graphic available
Description	Protein FAM5A precursor (Deleted in bladder cancer 1 protein).

FAM5A_MOUSE
θ value	5.27518 (rank : 69)	NC score	0.019491 (rank : 248)
Query Neighborhood Hits	90	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q920P3, Q80ZL2, Q812F0, Q8C1C9, Q920P4, Q9QXL0	Gene names	Fam5a, Brinp, Brinp1, Dbccr1
Domain Architecture	No domain graphic available
Description	Protein FAM5A precursor (Deleted in bladder cancer 1 protein homolog) (BMP/retinoic acid-inducible neural-specific protein 1).

LAMA5_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.087837 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	976	Shared Neighborhood Hits	53
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

PROP_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.133023 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

SREC2_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.118015 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	605	Shared Neighborhood Hits	57
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SYTL3_MOUSE
θ value	5.27518 (rank : 73)	NC score	0.006881 (rank : 250)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

ATS9_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.061069 (rank : 167)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CREL1_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.127330 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	524	Shared Neighborhood Hits	49
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

RS8_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.021776 (rank : 245)
Query Neighborhood Hits	90	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P62241, P09058, Q6IRL7	Gene names	RPS8
Domain Architecture
Description	40S ribosomal protein S8.

RS8_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.021776 (rank : 246)
Query Neighborhood Hits	90	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P62242, P09058, Q8C2G6	Gene names	Rps8
Domain Architecture
Description	40S ribosomal protein S8.

SCUB3_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.079269 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	428	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SEM5B_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.049853 (rank : 235)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

ATS16_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.069506 (rank : 125)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS8_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.039554 (rank : 240)
Query Neighborhood Hits	90	Target Neighborhood Hits	139	Shared Neighborhood Hits	24
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

BAI3_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.080213 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BMPER_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.082918 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

CO9_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.023762 (rank : 243)
Query Neighborhood Hits	90	Target Neighborhood Hits	153	Shared Neighborhood Hits	17
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

ERBB3_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.039726 (rank : 239)
Query Neighborhood Hits	90	Target Neighborhood Hits	898	Shared Neighborhood Hits	32
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

FBN2_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.080853 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	549	Shared Neighborhood Hits	52
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

ITB7_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.043652 (rank : 237)
Query Neighborhood Hits	90	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	P26010	Gene names	ITGB7
Domain Architecture
Description	Integrin beta-7 precursor.

NUAK2_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.004536 (rank : 251)
Query Neighborhood Hits	90	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

TNAP3_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.015086 (rank : 249)
Query Neighborhood Hits	90	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q60769	Gene names	Tnfaip3, Tnfip3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

WFDC8_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.023625 (rank : 244)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

AGRIN_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.066341 (rank : 137)
Query Neighborhood Hits	90	Target Neighborhood Hits	582	Shared Neighborhood Hits	43
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ATL2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.050675 (rank : 227)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL2_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.051290 (rank : 222)
Query Neighborhood Hits	90	Target Neighborhood Hits	137	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATS12_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.051645 (rank : 219)
Query Neighborhood Hits	90	Target Neighborhood Hits	251	Shared Neighborhood Hits	29
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS12_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.053976 (rank : 203)
Query Neighborhood Hits	90	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

BAI1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.077787 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	340	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI3_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.079208 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	250	Shared Neighborhood Hits	38
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BMPER_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.098640 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

C1QR1_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.062171 (rank : 156)
Query Neighborhood Hits	90	Target Neighborhood Hits	493	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

C1QR1_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.052638 (rank : 216)
Query Neighborhood Hits	90	Target Neighborhood Hits	342	Shared Neighborhood Hits	38
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

CILP1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.062495 (rank : 155)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	35
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP2_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.058284 (rank : 187)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CO6_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.052237 (rank : 217)
Query Neighborhood Hits	90	Target Neighborhood Hits	331	Shared Neighborhood Hits	41
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CREL1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.120665 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	441	Shared Neighborhood Hits	44
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CRUM1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.050944 (rank : 226)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	38
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.053040 (rank : 211)
Query Neighborhood Hits	90	Target Neighborhood Hits	444	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

CRUM2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.050662 (rank : 229)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	42
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

DLK_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.051066 (rank : 225)
Query Neighborhood Hits	90	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DLL1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.053669 (rank : 205)
Query Neighborhood Hits	90	Target Neighborhood Hits	455	Shared Neighborhood Hits	45
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.055125 (rank : 196)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	46
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

DLL3_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.053292 (rank : 209)
Query Neighborhood Hits	90	Target Neighborhood Hits	419	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

DLL3_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.057178 (rank : 190)
Query Neighborhood Hits	90	Target Neighborhood Hits	399	Shared Neighborhood Hits	43
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DLL4_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.058298 (rank : 186)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DLL4_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.061402 (rank : 164)
Query Neighborhood Hits	90	Target Neighborhood Hits	440	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DNER_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.051099 (rank : 224)
Query Neighborhood Hits	90	Target Neighborhood Hits	460	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

EGFL9_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.051316 (rank : 221)
Query Neighborhood Hits	90	Target Neighborhood Hits	365	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

FBLN1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.065895 (rank : 140)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	38
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

FBLN1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.064986 (rank : 143)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.061855 (rank : 159)
Query Neighborhood Hits	90	Target Neighborhood Hits	392	Shared Neighborhood Hits	41
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.061906 (rank : 158)
Query Neighborhood Hits	90	Target Neighborhood Hits	505	Shared Neighborhood Hits	42
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN3_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.052684 (rank : 213)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FBLN4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.050401 (rank : 231)
Query Neighborhood Hits	90	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

FBLN4_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.052966 (rank : 212)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN5_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.066102 (rank : 139)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBLN5_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.069271 (rank : 126)
Query Neighborhood Hits	90	Target Neighborhood Hits	317	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

FBN3_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.080866 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	543	Shared Neighborhood Hits	44
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FREM1_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.050237 (rank : 233)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.062550 (rank : 154)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

FREM2_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.062995 (rank : 153)
Query Neighborhood Hits	90	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

FREM3_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.055086 (rank : 197)
Query Neighborhood Hits	90	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

FREM3_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.054781 (rank : 198)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

GRN_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.060167 (rank : 173)
Query Neighborhood Hits	90	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

GRN_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.059667 (rank : 178)
Query Neighborhood Hits	90	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

ITB3_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.050169 (rank : 234)
Query Neighborhood Hits	90	Target Neighborhood Hits	319	Shared Neighborhood Hits	39
SwissProt Accessions	O54890	Gene names	Itgb3
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

JAG1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.061821 (rank : 160)
Query Neighborhood Hits	90	Target Neighborhood Hits	514	Shared Neighborhood Hits	41
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.061177 (rank : 166)
Query Neighborhood Hits	90	Target Neighborhood Hits	518	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.063777 (rank : 150)
Query Neighborhood Hits	90	Target Neighborhood Hits	491	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.060178 (rank : 172)
Query Neighborhood Hits	90	Target Neighborhood Hits	504	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KR101_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.077203 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	261	Shared Neighborhood Hits	40
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR102_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.061958 (rank : 157)
Query Neighborhood Hits	90	Target Neighborhood Hits	264	Shared Neighborhood Hits	40
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

KR104_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.089167 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	313	Shared Neighborhood Hits	40
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR105_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.065346 (rank : 141)
Query Neighborhood Hits	90	Target Neighborhood Hits	271	Shared Neighborhood Hits	30
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR106_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.087521 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.087820 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	330	Shared Neighborhood Hits	40
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR108_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.071854 (rank : 115)
Query Neighborhood Hits	90	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

KR109_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.064208 (rank : 148)
Query Neighborhood Hits	90	Target Neighborhood Hits	226	Shared Neighborhood Hits	33
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR10B_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.067482 (rank : 131)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KR10C_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.056064 (rank : 193)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	36
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KR171_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.055693 (rank : 195)
Query Neighborhood Hits	90	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

KR410_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.052683 (rank : 214)
Query Neighborhood Hits	90	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

KR412_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.066297 (rank : 138)
Query Neighborhood Hits	90	Target Neighborhood Hits	178	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

KR414_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.059303 (rank : 182)
Query Neighborhood Hits	90	Target Neighborhood Hits	199	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYQ6	Gene names	KRTAP4-14, KAP4.14, KRTAP4.14
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-14 (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14).

KR510_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.086803 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G5	Gene names	KRTAP5-10, KAP5.10, KRTAP5.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10).

KR511_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.075410 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

KRA11_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.051436 (rank : 220)
Query Neighborhood Hits	90	Target Neighborhood Hits	155	Shared Neighborhood Hits	21
SwissProt Accessions	Q07627, Q96S60, Q96S67	Gene names	KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-1 (Keratin-associated protein 1.1) (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7).

KRA13_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.053258 (rank : 210)
Query Neighborhood Hits	90	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IUG1, Q07628, Q8IUG0, Q9BYS2	Gene names	KRTAP1-3, B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9).

KRA44_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.056340 (rank : 192)
Query Neighborhood Hits	90	Target Neighborhood Hits	162	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYR3	Gene names	KRTAP4-4, KAP4.4, KRTAP4.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-4 (Keratin-associated protein 4.4) (Ultrahigh sulfur keratin-associated protein 4.4).

KRA45_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.071044 (rank : 119)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

KRA47_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.072701 (rank : 112)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

KRA51_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.112781 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	38
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.095464 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA53_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.109783 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	331	Shared Neighborhood Hits	46
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA54_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.103421 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	34
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.111594 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA56_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.084612 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	207	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

KRA57_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.088067 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.092015 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	41
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.096808 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA92_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.064878 (rank : 145)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.073037 (rank : 110)
Query Neighborhood Hits	90	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

KRA94_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.061226 (rank : 165)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

KRA98_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.068732 (rank : 129)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

KRA99_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.061470 (rank : 163)
Query Neighborhood Hits	90	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

LAMA1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.080169 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	838	Shared Neighborhood Hits	48
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA3_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.061668 (rank : 162)
Query Neighborhood Hits	90	Target Neighborhood Hits	760	Shared Neighborhood Hits	39
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

LAMA4_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.059502 (rank : 179)
Query Neighborhood Hits	90	Target Neighborhood Hits	708	Shared Neighborhood Hits	36
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMA4_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.063364 (rank : 151)
Query Neighborhood Hits	90	Target Neighborhood Hits	584	Shared Neighborhood Hits	38
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMB1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.059810 (rank : 177)
Query Neighborhood Hits	90	Target Neighborhood Hits	1018	Shared Neighborhood Hits	37
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.064876 (rank : 146)
Query Neighborhood Hits	90	Target Neighborhood Hits	919	Shared Neighborhood Hits	38
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.075839 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	692	Shared Neighborhood Hits	44
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

LAMB2_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.072441 (rank : 114)
Query Neighborhood Hits	90	Target Neighborhood Hits	722	Shared Neighborhood Hits	43
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

LAMB3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.058884 (rank : 183)
Query Neighborhood Hits	90	Target Neighborhood Hits	461	Shared Neighborhood Hits	34
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

LAMB3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.059405 (rank : 180)
Query Neighborhood Hits	90	Target Neighborhood Hits	444	Shared Neighborhood Hits	37
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

LAMC1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.071206 (rank : 118)
Query Neighborhood Hits	90	Target Neighborhood Hits	922	Shared Neighborhood Hits	46
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMC1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.070879 (rank : 120)
Query Neighborhood Hits	90	Target Neighborhood Hits	856	Shared Neighborhood Hits	45
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMC2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.067324 (rank : 132)
Query Neighborhood Hits	90	Target Neighborhood Hits	614	Shared Neighborhood Hits	41
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

LAMC3_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.081876 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	588	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LAMC3_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.075875 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	624	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LCE1A_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.075436 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1B_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.092380 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.072762 (rank : 111)
Query Neighborhood Hits	90	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1E_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.069956 (rank : 123)
Query Neighborhood Hits	90	Target Neighborhood Hits	53	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1F_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.081737 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LRP1B_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.050567 (rank : 230)
Query Neighborhood Hits	90	Target Neighborhood Hits	602	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.050261 (rank : 232)
Query Neighborhood Hits	90	Target Neighborhood Hits	617	Shared Neighborhood Hits	51
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.053379 (rank : 207)
Query Neighborhood Hits	90	Target Neighborhood Hits	573	Shared Neighborhood Hits	51
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

LTB1L_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.070255 (rank : 122)
Query Neighborhood Hits	90	Target Neighborhood Hits	553	Shared Neighborhood Hits	44
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.070408 (rank : 121)
Query Neighborhood Hits	90	Target Neighborhood Hits	502	Shared Neighborhood Hits	44
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP2_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.086587 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	617	Shared Neighborhood Hits	50
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.061795 (rank : 161)
Query Neighborhood Hits	90	Target Neighborhood Hits	502	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP3_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.064746 (rank : 147)
Query Neighborhood Hits	90	Target Neighborhood Hits	475	Shared Neighborhood Hits	43
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

MATN2_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.060215 (rank : 171)
Query Neighborhood Hits	90	Target Neighborhood Hits	365	Shared Neighborhood Hits	39
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN2_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.058723 (rank : 185)
Query Neighborhood Hits	90	Target Neighborhood Hits	356	Shared Neighborhood Hits	38
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

MEGF8_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.085810 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	528	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MEGF8_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.085085 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	520	Shared Neighborhood Hits	45
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MT3_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.053858 (rank : 204)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	P25713, Q2V574	Gene names	MT3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF) (GIFB).

MT3_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.052673 (rank : 215)
Query Neighborhood Hits	90	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	P28184	Gene names	Mt3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF).

MUC5B_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.054340 (rank : 201)
Query Neighborhood Hits	90	Target Neighborhood Hits	1020	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NAGPA_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.054432 (rank : 200)
Query Neighborhood Hits	90	Target Neighborhood Hits	282	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NAGPA_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.053522 (rank : 206)
Query Neighborhood Hits	90	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NEC1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.103259 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.103119 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.101563 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.101716 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NELL1_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.083046 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	451	Shared Neighborhood Hits	46
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.071302 (rank : 117)
Query Neighborhood Hits	90	Target Neighborhood Hits	449	Shared Neighborhood Hits	42
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.069176 (rank : 127)
Query Neighborhood Hits	90	Target Neighborhood Hits	436	Shared Neighborhood Hits	41
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NFX1_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.060338 (rank : 169)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	34
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

NOTC2_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.067564 (rank : 130)
Query Neighborhood Hits	90	Target Neighborhood Hits	1113	Shared Neighborhood Hits	53
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.060014 (rank : 174)
Query Neighborhood Hits	90	Target Neighborhood Hits	1069	Shared Neighborhood Hits	45
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.066627 (rank : 135)
Query Neighborhood Hits	90	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.063961 (rank : 149)
Query Neighborhood Hits	90	Target Neighborhood Hits	975	Shared Neighborhood Hits	55
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC4_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.064967 (rank : 144)
Query Neighborhood Hits	90	Target Neighborhood Hits	905	Shared Neighborhood Hits	52
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.059950 (rank : 175)
Query Neighborhood Hits	90	Target Neighborhood Hits	872	Shared Neighborhood Hits	49
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PCSK4_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.117085 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.105890 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

PCSK7_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.100383 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.100312 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

STAB1_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.060811 (rank : 168)
Query Neighborhood Hits	90	Target Neighborhood Hits	546	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

STAB1_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.060259 (rank : 170)
Query Neighborhood Hits	90	Target Neighborhood Hits	566	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

STAB2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.059393 (rank : 181)
Query Neighborhood Hits	90	Target Neighborhood Hits	534	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

STAB2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.057540 (rank : 188)
Query Neighborhood Hits	90	Target Neighborhood Hits	528	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TENA_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.054662 (rank : 199)
Query Neighborhood Hits	90	Target Neighborhood Hits	631	Shared Neighborhood Hits	48
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENA_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.051746 (rank : 218)
Query Neighborhood Hits	90	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TENX_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.058791 (rank : 184)
Query Neighborhood Hits	90	Target Neighborhood Hits	789	Shared Neighborhood Hits	54
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TNR14_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.065137 (rank : 142)
Query Neighborhood Hits	90	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

TNR16_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.054135 (rank : 202)
Query Neighborhood Hits	90	Target Neighborhood Hits	183	Shared Neighborhood Hits	31
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TNR9_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.050667 (rank : 228)
Query Neighborhood Hits	90	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

TRBM_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.057150 (rank : 191)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	37
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TRBM_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.057418 (rank : 189)
Query Neighborhood Hits	90	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TSP1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.090485 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	65
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.090844 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	64
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.083109 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	359	Shared Neighborhood Hits	60
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

TSP2_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.083729 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	352	Shared Neighborhood Hits	57
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

USH2A_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.068974 (rank : 128)
Query Neighborhood Hits	90	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.074474 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	626	Shared Neighborhood Hits	44
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VWF_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.069894 (rank : 124)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.071853 (rank : 116)
Query Neighborhood Hits	90	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

WIF1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.075783 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	392	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

WIF1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.077758 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	393	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

ZAN_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.097129 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	808	Shared Neighborhood Hits	56
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

RSPO2_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.1664e-140 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
NC score	0.997717 (rank : 2)	θ value	3.88293e-136 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	88	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_MOUSE
NC score	0.947329 (rank : 3)	θ value	1.66964e-54 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	64
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO3_HUMAN
NC score	0.945718 (rank : 4)	θ value	1.97229e-55 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	128	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO1_MOUSE
NC score	0.937904 (rank : 5)	θ value	2.1121e-49 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO1_HUMAN
NC score	0.934779 (rank : 6)	θ value	2.25659e-51 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO4_HUMAN
NC score	0.927139 (rank : 7)	θ value	1.01294e-51 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
NC score	0.925272 (rank : 8)	θ value	8.57503e-51 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

PCSK6_HUMAN
NC score	0.317999 (rank : 9)	θ value	9.92553e-07 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	56
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
NC score	0.313270 (rank : 10)	θ value	1.99992e-07 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.312636 (rank : 11)	θ value	1.38499e-08 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	613	Shared Neighborhood Hits	69
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

SPON2_HUMAN
NC score	0.311742 (rank : 12)	θ value	0.00035302 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	53	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

SPON2_MOUSE
NC score	0.308550 (rank : 13)	θ value	0.00020696 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	42	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

FRAS1_MOUSE
NC score	0.273019 (rank : 14)	θ value	8.11959e-09 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	747	Shared Neighborhood Hits	74
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.269487 (rank : 15)	θ value	1.53129e-07 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	759	Shared Neighborhood Hits	75
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

SPON1_MOUSE
NC score	0.253031 (rank : 16)	θ value	3.19293e-05 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

SPON1_HUMAN
NC score	0.252040 (rank : 17)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

FURIN_HUMAN
NC score	0.176466 (rank : 18)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	52	Shared Neighborhood Hits	20
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
NC score	0.171584 (rank : 19)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

SSPO_MOUSE
NC score	0.152836 (rank : 20)	θ value	0.00298849 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	800	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

PROP_MOUSE
NC score	0.148945 (rank : 21)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

PROP_HUMAN
NC score	0.133023 (rank : 22)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

CREL1_MOUSE
NC score	0.127330 (rank : 23)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	524	Shared Neighborhood Hits	49
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

TNR6B_HUMAN
NC score	0.122720 (rank : 24)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

CREL1_HUMAN
NC score	0.120665 (rank : 25)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	441	Shared Neighborhood Hits	44
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

SREC_HUMAN
NC score	0.119426 (rank : 26)	θ value	0.0193708 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	645	Shared Neighborhood Hits	58
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SREC2_HUMAN
NC score	0.119383 (rank : 27)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	645	Shared Neighborhood Hits	57
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MEGF6_HUMAN
NC score	0.119218 (rank : 28)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	671	Shared Neighborhood Hits	61
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

SREC2_MOUSE
NC score	0.118015 (rank : 29)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	605	Shared Neighborhood Hits	57
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

PCSK4_HUMAN
NC score	0.117085 (rank : 30)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

CRIM1_HUMAN
NC score	0.116358 (rank : 31)	θ value	0.813845 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA51_HUMAN
NC score	0.112781 (rank : 32)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	90	Target Neighborhood Hits	288	Shared Neighborhood Hits	38
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA55_HUMAN
NC score	0.111594 (rank : 33)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA53_HUMAN
NC score	0.109783 (rank : 34)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	90	Target Neighborhood Hits	331	Shared Neighborhood Hits	46
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

PCSK4_MOUSE
NC score	0.105890 (rank : 35)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

MEGF9_MOUSE
NC score	0.105829 (rank : 36)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

KRA54_HUMAN
NC score	0.103421 (rank : 37)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	34
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

NEC1_HUMAN
NC score	0.103259 (rank : 38)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
NC score	0.103119 (rank : 39)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	90	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC2_MOUSE
NC score	0.101716 (rank : 40)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_HUMAN
NC score	0.101563 (rank : 41)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_HUMAN
NC score	0.100383 (rank : 42)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	90	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.100312 (rank : 43)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

MEGF9_HUMAN
NC score	0.100279 (rank : 44)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	557	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

LTBP4_MOUSE
NC score	0.099495 (rank : 45)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	607	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

BMPER_HUMAN
NC score	0.098640 (rank : 46)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

ZAN_MOUSE
NC score	0.097129 (rank : 47)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	90	Target Neighborhood Hits	808	Shared Neighborhood Hits	56
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KRA59_HUMAN
NC score	0.096808 (rank : 48)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA52_HUMAN
NC score	0.095464 (rank : 49)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	90	Target Neighborhood Hits	236	Shared Neighborhood Hits	34
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

BAI2_HUMAN
NC score	0.094403 (rank : 50)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
NC score	0.093352 (rank : 51)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	323	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

LCE1B_HUMAN
NC score	0.092380 (rank : 52)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	90	Target Neighborhood Hits	58	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

KRA58_HUMAN
NC score	0.092015 (rank : 53)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	41
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

FBN1_HUMAN
NC score	0.091077 (rank : 54)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	557	Shared Neighborhood Hits	54
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

TSP1_MOUSE
NC score	0.090844 (rank : 55)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	64
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

FBN1_MOUSE
NC score	0.090492 (rank : 56)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	563	Shared Neighborhood Hits	50
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

TSP1_HUMAN
NC score	0.090485 (rank : 57)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	90	Target Neighborhood Hits	389	Shared Neighborhood Hits	65
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

KR104_HUMAN
NC score	0.089167 (rank : 58)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	90	Target Neighborhood Hits	313	Shared Neighborhood Hits	40
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

LAMA1_HUMAN
NC score	0.088635 (rank : 59)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	804	Shared Neighborhood Hits	49
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

KRA57_HUMAN
NC score	0.088067 (rank : 60)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

LAMA5_HUMAN
NC score	0.087837 (rank : 61)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	976	Shared Neighborhood Hits	53
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

KR107_HUMAN
NC score	0.087820 (rank : 62)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	90	Target Neighborhood Hits	330	Shared Neighborhood Hits	40
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR106_HUMAN
NC score	0.087521 (rank : 63)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	90	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

TNR5_MOUSE
NC score	0.087464 (rank : 64)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

SCUB3_MOUSE
NC score	0.087306 (rank : 65)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	442	Shared Neighborhood Hits	44
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

KR510_HUMAN
NC score	0.086803 (rank : 66)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G5	Gene names	KRTAP5-10, KAP5.10, KRTAP5.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10).

LTBP2_MOUSE
NC score	0.086587 (rank : 67)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	90	Target Neighborhood Hits	617	Shared Neighborhood Hits	50
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

BAI1_HUMAN
NC score	0.086187 (rank : 68)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	375	Shared Neighborhood Hits	39
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

MEGF8_HUMAN
NC score	0.085810 (rank : 69)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	90	Target Neighborhood Hits	528	Shared Neighborhood Hits	44
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MEGF8_MOUSE
NC score	0.085085 (rank : 70)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	90	Target Neighborhood Hits	520	Shared Neighborhood Hits	45
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

KRA56_HUMAN
NC score	0.084612 (rank : 71)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	90	Target Neighborhood Hits	207	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

TSP2_MOUSE
NC score	0.083729 (rank : 72)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	90	Target Neighborhood Hits	352	Shared Neighborhood Hits	57
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

HMCN1_HUMAN
NC score	0.083716 (rank : 73)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	983	Shared Neighborhood Hits	70
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

LAMA2_HUMAN
NC score	0.083526 (rank : 74)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	1092	Shared Neighborhood Hits	51
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

TSP2_HUMAN
NC score	0.083109 (rank : 75)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	90	Target Neighborhood Hits	359	Shared Neighborhood Hits	60
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

NELL1_HUMAN
NC score	0.083046 (rank : 76)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	90	Target Neighborhood Hits	451	Shared Neighborhood Hits	46
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

BMPER_MOUSE
NC score	0.082918 (rank : 77)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

LAMA5_MOUSE
NC score	0.082528 (rank : 78)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	828	Shared Neighborhood Hits	47
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

IGF1R_MOUSE
NC score	0.082359 (rank : 79)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.082221 (rank : 80)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	950	Shared Neighborhood Hits	41
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

FBN2_HUMAN
NC score	0.081967 (rank : 81)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	560	Shared Neighborhood Hits	52
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

LAMC3_HUMAN
NC score	0.081876 (rank : 82)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	90	Target Neighborhood Hits	588	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LCE1F_HUMAN
NC score	0.081737 (rank : 83)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	90	Target Neighborhood Hits	48	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

FBN3_HUMAN
NC score	0.080866 (rank : 84)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	90	Target Neighborhood Hits	543	Shared Neighborhood Hits	44
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FBN2_MOUSE
NC score	0.080853 (rank : 85)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	549	Shared Neighborhood Hits	52
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

IGF1R_HUMAN
NC score	0.080613 (rank : 86)	θ value	0.00102713 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	977	Shared Neighborhood Hits	42
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LAMA2_MOUSE
NC score	0.080422 (rank : 87)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	1198	Shared Neighborhood Hits	51
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

BAI3_HUMAN
NC score	0.080213 (rank : 88)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

LAMA1_MOUSE
NC score	0.080169 (rank : 89)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	90	Target Neighborhood Hits	838	Shared Neighborhood Hits	48
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

INSRR_MOUSE
NC score	0.079391 (rank : 90)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	961	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LTBP2_HUMAN
NC score	0.079302 (rank : 91)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	552	Shared Neighborhood Hits	49
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

SCUB3_HUMAN
NC score	0.079269 (rank : 92)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	428	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

BAI3_MOUSE
NC score	0.079208 (rank : 93)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	250	Shared Neighborhood Hits	38
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

NOTC1_HUMAN
NC score	0.078455 (rank : 94)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	906	Shared Neighborhood Hits	56
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
NC score	0.077985 (rank : 95)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	916	Shared Neighborhood Hits	51
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

BAI1_MOUSE
NC score	0.077787 (rank : 96)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	340	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

WIF1_MOUSE
NC score	0.077758 (rank : 97)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	90	Target Neighborhood Hits	393	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

INSR_MOUSE
NC score	0.077584 (rank : 98)	θ value	0.000786445 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	968	Shared Neighborhood Hits	39
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KR101_HUMAN
NC score	0.077203 (rank : 99)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	90	Target Neighborhood Hits	261	Shared Neighborhood Hits	40
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

LAMC3_MOUSE
NC score	0.075875 (rank : 100)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	90	Target Neighborhood Hits	624	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

LAMB2_HUMAN
NC score	0.075839 (rank : 101)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	90	Target Neighborhood Hits	692	Shared Neighborhood Hits	44
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

WIF1_HUMAN
NC score	0.075783 (rank : 102)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	90	Target Neighborhood Hits	392	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

LTB1S_MOUSE
NC score	0.075493 (rank : 103)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

INSR_HUMAN
NC score	0.075468 (rank : 104)	θ value	0.00298849 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	963	Shared Neighborhood Hits	38
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

LCE1A_HUMAN
NC score	0.075436 (rank : 105)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	90	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

KR511_HUMAN
NC score	0.075410 (rank : 106)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	90	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8G4	Gene names	KRTAP5-11, KAP5.11, KRTAP5.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-11 (Keratin-associated protein 5.11) (Ultrahigh sulfur keratin-associated protein 5.11).

USH2A_MOUSE
NC score	0.074474 (rank : 107)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	90	Target Neighborhood Hits	626	Shared Neighborhood Hits	44
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

LAMA3_MOUSE
NC score	0.073560 (rank : 108)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	859	Shared Neighborhood Hits	47
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

ATS20_MOUSE
NC score	0.073216 (rank : 109)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

KRA93_HUMAN
NC score	0.073037 (rank : 110)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	90	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

LCE1C_HUMAN
NC score	0.072762 (rank : 111)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	90	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

KRA47_HUMAN
NC score	0.072701 (rank : 112)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

LTB1L_MOUSE
NC score	0.072687 (rank : 113)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	514	Shared Neighborhood Hits	50
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LAMB2_MOUSE
NC score	0.072441 (rank : 114)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	90	Target Neighborhood Hits	722	Shared Neighborhood Hits	43
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

KR108_HUMAN
NC score	0.071854 (rank : 115)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	90	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

VWF_MOUSE
NC score	0.071853 (rank : 116)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	90	Target Neighborhood Hits	381	Shared Neighborhood Hits	51
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

NELL2_HUMAN
NC score	0.071302 (rank : 117)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	90	Target Neighborhood Hits	449	Shared Neighborhood Hits	42
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

LAMC1_HUMAN
NC score	0.071206 (rank : 118)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	90	Target Neighborhood Hits	922	Shared Neighborhood Hits	46
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

KRA45_HUMAN
NC score	0.071044 (rank : 119)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

LAMC1_MOUSE
NC score	0.070879 (rank : 120)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	90	Target Neighborhood Hits	856	Shared Neighborhood Hits	45
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LTB1S_HUMAN
NC score	0.070408 (rank : 121)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	90	Target Neighborhood Hits	502	Shared Neighborhood Hits	44
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_HUMAN
NC score	0.070255 (rank : 122)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	90	Target Neighborhood Hits	553	Shared Neighborhood Hits	44
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LCE1E_HUMAN
NC score	0.069956 (rank : 123)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	90	Target Neighborhood Hits	53	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

VWF_HUMAN
NC score	0.069894 (rank : 124)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATS16_MOUSE
NC score	0.069506 (rank : 125)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

FBLN5_MOUSE
NC score	0.069271 (rank : 126)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	90	Target Neighborhood Hits	317	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

NELL2_MOUSE
NC score	0.069176 (rank : 127)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	90	Target Neighborhood Hits	436	Shared Neighborhood Hits	41
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

USH2A_HUMAN
NC score	0.068974 (rank : 128)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	90	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

KRA98_HUMAN
NC score	0.068732 (rank : 129)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	90	Target Neighborhood Hits	185	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

NOTC2_HUMAN
NC score	0.067564 (rank : 130)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	90	Target Neighborhood Hits	1113	Shared Neighborhood Hits	53
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

KR10B_HUMAN
NC score	0.067482 (rank : 131)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

LAMC2_MOUSE
NC score	0.067324 (rank : 132)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	90	Target Neighborhood Hits	614	Shared Neighborhood Hits	41
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

LAMC2_HUMAN
NC score	0.067315 (rank : 133)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	715	Shared Neighborhood Hits	40
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

ATS20_HUMAN
NC score	0.066788 (rank : 134)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	192	Shared Neighborhood Hits	38
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

NOTC3_HUMAN
NC score	0.066627 (rank : 135)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	90	Target Neighborhood Hits	1062	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ATS17_HUMAN
NC score	0.066440 (rank : 136)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	194	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

AGRIN_HUMAN
NC score	0.066341 (rank : 137)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	582	Shared Neighborhood Hits	43
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

KR412_HUMAN
NC score	0.066297 (rank : 138)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	90	Target Neighborhood Hits	178	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BQ66, Q495I0	Gene names	KRTAP4-12, KAP4.12, KRTAP4.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-12 (Keratin-associated protein 4.12) (Ultrahigh sulfur keratin-associated protein 4.12).

FBLN5_HUMAN
NC score	0.066102 (rank : 139)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

FBLN1_HUMAN
NC score	0.065895 (rank : 140)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	90	Target Neighborhood Hits	324	Shared Neighborhood Hits	38
SwissProt Accessions	P23142, P23143, P23144, P37888, Q5TIC4, Q8TBH8, Q9HBQ5, Q9UC21, Q9UGR4, Q9UH41	Gene names	FBLN1
Domain Architecture
Description	Fibulin-1 precursor.

KR105_HUMAN
NC score	0.065346 (rank : 141)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	90	Target Neighborhood Hits	271	Shared Neighborhood Hits	30
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

TNR14_HUMAN
NC score	0.065137 (rank : 142)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	90	Target Neighborhood Hits	149	Shared Neighborhood Hits	35
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

FBLN1_MOUSE
NC score	0.064986 (rank : 143)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

NOTC4_HUMAN
NC score	0.064967 (rank : 144)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	90	Target Neighborhood Hits	905	Shared Neighborhood Hits	52
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

KRA92_HUMAN
NC score	0.064878 (rank : 145)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

LAMB1_MOUSE
NC score	0.064876 (rank : 146)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	90	Target Neighborhood Hits	919	Shared Neighborhood Hits	38
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LTBP3_MOUSE
NC score	0.064746 (rank : 147)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	90	Target Neighborhood Hits	475	Shared Neighborhood Hits	43
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

KR109_HUMAN
NC score	0.064208 (rank : 148)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	90	Target Neighborhood Hits	226	Shared Neighborhood Hits	33
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

NOTC3_MOUSE
NC score	0.063961 (rank : 149)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	90	Target Neighborhood Hits	975	Shared Neighborhood Hits	55
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

JAG2_HUMAN
NC score	0.063777 (rank : 150)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	90	Target Neighborhood Hits	491	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

LAMA4_MOUSE
NC score	0.063364 (rank : 151)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	90	Target Neighborhood Hits	584	Shared Neighborhood Hits	38
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

ATS16_HUMAN
NC score	0.063254 (rank : 152)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	208	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

FREM2_MOUSE
NC score	0.062995 (rank : 153)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	90	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

FREM2_HUMAN
NC score	0.062550 (rank : 154)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

CILP1_HUMAN
NC score	0.062495 (rank : 155)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	35
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

C1QR1_HUMAN
NC score	0.062171 (rank : 156)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	493	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

KR102_HUMAN
NC score	0.061958 (rank : 157)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	90	Target Neighborhood Hits	264	Shared Neighborhood Hits	40
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

FBLN2_MOUSE
NC score	0.061906 (rank : 158)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	90	Target Neighborhood Hits	505	Shared Neighborhood Hits	42
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_HUMAN
NC score	0.061855 (rank : 159)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	90	Target Neighborhood Hits	392	Shared Neighborhood Hits	41
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

JAG1_HUMAN
NC score	0.061821 (rank : 160)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	90	Target Neighborhood Hits	514	Shared Neighborhood Hits	41
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

LTBP3_HUMAN
NC score	0.061795 (rank : 161)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	90	Target Neighborhood Hits	502	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LAMA3_HUMAN
NC score	0.061668 (rank : 162)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	90	Target Neighborhood Hits	760	Shared Neighborhood Hits	39
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

KRA99_HUMAN
NC score	0.061470 (rank : 163)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	90	Target Neighborhood Hits	173	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

DLL4_MOUSE
NC score	0.061402 (rank : 164)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	90	Target Neighborhood Hits	440	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

KRA94_HUMAN
NC score	0.061226 (rank : 165)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	90	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

JAG1_MOUSE
NC score	0.061177 (rank : 166)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	90	Target Neighborhood Hits	518	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

ATS9_HUMAN
NC score	0.061069 (rank : 167)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	33
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

STAB1_HUMAN
NC score	0.060811 (rank : 168)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	90	Target Neighborhood Hits	546	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

NFX1_HUMAN
NC score	0.060338 (rank : 169)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	90	Target Neighborhood Hits	405	Shared Neighborhood Hits	34
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

STAB1_MOUSE
NC score	0.060259 (rank : 170)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	90	Target Neighborhood Hits	566	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

MATN2_HUMAN
NC score	0.060215 (rank : 171)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	90	Target Neighborhood Hits	365	Shared Neighborhood Hits	39
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

JAG2_MOUSE
NC score	0.060178 (rank : 172)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	90	Target Neighborhood Hits	504	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

GRN_HUMAN
NC score	0.060167 (rank : 173)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	90	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

NOTC2_MOUSE
NC score	0.060014 (rank : 174)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	90	Target Neighborhood Hits	1069	Shared Neighborhood Hits	45
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC4_MOUSE
NC score	0.059950 (rank : 175)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	90	Target Neighborhood Hits	872	Shared Neighborhood Hits	49
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

PGBM_MOUSE
NC score	0.059912 (rank : 176)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	1073	Shared Neighborhood Hits	50
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

LAMB1_HUMAN
NC score	0.059810 (rank : 177)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	90	Target Neighborhood Hits	1018	Shared Neighborhood Hits	37
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

GRN_MOUSE
NC score	0.059667 (rank : 178)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	90	Target Neighborhood Hits	248	Shared Neighborhood Hits	35
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

LAMA4_HUMAN
NC score	0.059502 (rank : 179)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	90	Target Neighborhood Hits	708	Shared Neighborhood Hits	36
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMB3_MOUSE
NC score	0.059405 (rank : 180)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	90	Target Neighborhood Hits	444	Shared Neighborhood Hits	37
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

STAB2_HUMAN
NC score	0.059393 (rank : 181)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	90	Target Neighborhood Hits	534	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

KR414_HUMAN
NC score	0.059303 (rank : 182)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	90	Target Neighborhood Hits	199	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYQ6	Gene names	KRTAP4-14, KAP4.14, KRTAP4.14
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-14 (Keratin-associated protein 4.14) (Ultrahigh sulfur keratin-associated protein 4.14).

LAMB3_HUMAN
NC score	0.058884 (rank : 183)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	90	Target Neighborhood Hits	461	Shared Neighborhood Hits	34
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

TENX_HUMAN
NC score	0.058791 (rank : 184)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	90	Target Neighborhood Hits	789	Shared Neighborhood Hits	54
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

MATN2_MOUSE
NC score	0.058723 (rank : 185)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	90	Target Neighborhood Hits	356	Shared Neighborhood Hits	38
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

DLL4_HUMAN
NC score	0.058298 (rank : 186)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

CILP2_HUMAN
NC score	0.058284 (rank : 187)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

STAB2_MOUSE
NC score	0.057540 (rank : 188)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	90	Target Neighborhood Hits	528	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TRBM_MOUSE
NC score	0.057418 (rank : 189)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	90	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

DLL3_MOUSE
NC score	0.057178 (rank : 190)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	90	Target Neighborhood Hits	399	Shared Neighborhood Hits	43
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

TRBM_HUMAN
NC score	0.057150 (rank : 191)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	37
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

KRA44_HUMAN
NC score	0.056340 (rank : 192)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	90	Target Neighborhood Hits	162	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYR3	Gene names	KRTAP4-4, KAP4.4, KRTAP4.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-4 (Keratin-associated protein 4.4) (Ultrahigh sulfur keratin-associated protein 4.4).

KR10C_HUMAN
NC score	0.056064 (rank : 193)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	90	Target Neighborhood Hits	219	Shared Neighborhood Hits	36
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

NID2_HUMAN
NC score	0.055743 (rank : 194)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	39
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

KR171_HUMAN
NC score	0.055693 (rank : 195)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	90	Target Neighborhood Hits	144	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

DLL1_MOUSE
NC score	0.055125 (rank : 196)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	46
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

FREM3_HUMAN
NC score	0.055086 (rank : 197)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	90	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

FREM3_MOUSE
NC score	0.054781 (rank : 198)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

TENA_HUMAN
NC score	0.054662 (rank : 199)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	90	Target Neighborhood Hits	631	Shared Neighborhood Hits	48
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

NAGPA_HUMAN
NC score	0.054432 (rank : 200)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	90	Target Neighborhood Hits	282	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

MUC5B_HUMAN
NC score	0.054340 (rank : 201)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	90	Target Neighborhood Hits	1020	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

TNR16_HUMAN
NC score	0.054135 (rank : 202)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	90	Target Neighborhood Hits	183	Shared Neighborhood Hits	31
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

ATS12_MOUSE
NC score	0.053976 (rank : 203)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

MT3_HUMAN
NC score	0.053858 (rank : 204)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	P25713, Q2V574	Gene names	MT3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF) (GIFB).

DLL1_HUMAN
NC score	0.053669 (rank : 205)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	90	Target Neighborhood Hits	455	Shared Neighborhood Hits	45
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

NAGPA_MOUSE
NC score	0.053522 (rank : 206)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	90	Target Neighborhood Hits	308	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

LRP2_HUMAN
NC score	0.053379 (rank : 207)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	90	Target Neighborhood Hits	573	Shared Neighborhood Hits	51
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

ATS13_HUMAN
NC score	0.053345 (rank : 208)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	238	Shared Neighborhood Hits	29
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

DLL3_HUMAN
NC score	0.053292 (rank : 209)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	90	Target Neighborhood Hits	419	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

KRA13_HUMAN
NC score	0.053258 (rank : 210)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	90	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IUG1, Q07628, Q8IUG0, Q9BYS2	Gene names	KRTAP1-3, B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-3 (Keratin-associated protein 1.8) (Keratin-associated protein 1.9).

CRUM1_MOUSE
NC score	0.053040 (rank : 211)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	444	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

FBLN4_MOUSE
NC score	0.052966 (rank : 212)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ9	Gene names	Efemp2, Fbln4, Mbp1
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (Mutant p53-binding protein 1).

FBLN3_HUMAN
NC score	0.052684 (rank : 213)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	90	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

KR410_HUMAN
NC score	0.052683 (rank : 214)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	90	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

MT3_MOUSE
NC score	0.052673 (rank : 215)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	90	Target Neighborhood Hits	68	Shared Neighborhood Hits	16
SwissProt Accessions	P28184	Gene names	Mt3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF).

C1QR1_MOUSE
NC score	0.052638 (rank : 216)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	342	Shared Neighborhood Hits	38
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

CO6_HUMAN
NC score	0.052237 (rank : 217)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	331	Shared Neighborhood Hits	41
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

TENA_MOUSE
NC score	0.051746 (rank : 218)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	90	Target Neighborhood Hits	596	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

ATS12_HUMAN
NC score	0.051645 (rank : 219)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	251	Shared Neighborhood Hits	29
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

KRA11_HUMAN
NC score	0.051436 (rank : 220)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	90	Target Neighborhood Hits	155	Shared Neighborhood Hits	21
SwissProt Accessions	Q07627, Q96S60, Q96S67	Gene names	KRTAP1-1, B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-1 (Keratin-associated protein 1.1) (High sulfur keratin-associated protein 1.1) (Keratin-associated protein 1.6) (Keratin-associated protein 1.7).

EGFL9_HUMAN
NC score	0.051316 (rank : 221)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	90	Target Neighborhood Hits	365	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

ATL2_MOUSE
NC score	0.051290 (rank : 222)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	137	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATS13_MOUSE
NC score	0.051284 (rank : 223)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	227	Shared Neighborhood Hits	32
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

DNER_HUMAN
NC score	0.051099 (rank : 224)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	90	Target Neighborhood Hits	460	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DLK_MOUSE
NC score	0.051066 (rank : 225)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	90	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

CRUM1_HUMAN
NC score	0.050944 (rank : 226)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	38
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

ATL2_HUMAN
NC score	0.050675 (rank : 227)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

TNR9_MOUSE
NC score	0.050667 (rank : 228)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	90	Target Neighborhood Hits	137	Shared Neighborhood Hits	24
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

CRUM2_HUMAN
NC score	0.050662 (rank : 229)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	42
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

LRP1B_HUMAN
NC score	0.050567 (rank : 230)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	90	Target Neighborhood Hits	602	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

FBLN4_HUMAN
NC score	0.050401 (rank : 231)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	90	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	O95967, O75967	Gene names	EFEMP2, FBLN4
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 2 precursor (Fibulin-4) (FIBL-4) (UPH1 protein).

LRP1_HUMAN
NC score	0.050261 (rank : 232)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	90	Target Neighborhood Hits	617	Shared Neighborhood Hits	51
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

FREM1_HUMAN
NC score	0.050237 (rank : 233)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

ITB3_MOUSE
NC score	0.050169 (rank : 234)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	90	Target Neighborhood Hits	319	Shared Neighborhood Hits	39
SwissProt Accessions	O54890	Gene names	Itgb3
Domain Architecture
Description	Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD61 antigen).

SEM5B_MOUSE
NC score	0.049853 (rank : 235)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

ATS3_HUMAN
NC score	0.049016 (rank : 236)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	179	Shared Neighborhood Hits	31
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ITB7_HUMAN
NC score	0.043652 (rank : 237)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	P26010	Gene names	ITGB7
Domain Architecture
Description	Integrin beta-7 precursor.

ATS7_HUMAN
NC score	0.039868 (rank : 238)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ERBB3_MOUSE
NC score	0.039726 (rank : 239)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	898	Shared Neighborhood Hits	32
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ATS8_MOUSE
NC score	0.039554 (rank : 240)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	139	Shared Neighborhood Hits	24
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

LHX4_MOUSE
NC score	0.024158 (rank : 241)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	457	Shared Neighborhood Hits	7
SwissProt Accessions	P53776, O08916, Q9R280	Gene names	Lhx4, Gsh-4, Gsh4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

LHX4_HUMAN
NC score	0.024151 (rank : 242)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	Q969G2, Q8NHE0, Q8TCJ1, Q8WWX2, Q969W2	Gene names	LHX4
Domain Architecture
Description	LIM/homeobox protein Lhx4.

CO9_MOUSE
NC score	0.023762 (rank : 243)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	153	Shared Neighborhood Hits	17
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

WFDC8_HUMAN
NC score	0.023625 (rank : 244)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

RS8_HUMAN
NC score	0.021776 (rank : 245)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P62241, P09058, Q6IRL7	Gene names	RPS8
Domain Architecture
Description	40S ribosomal protein S8.

RS8_MOUSE
NC score	0.021776 (rank : 246)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P62242, P09058, Q8C2G6	Gene names	Rps8
Domain Architecture
Description	40S ribosomal protein S8.

FAM5A_HUMAN
NC score	0.019505 (rank : 247)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O60477, Q6IPV6, Q6P1A0, Q8WU22	Gene names	FAM5A, DBC1, DBCCR1
Domain Architecture	No domain graphic available
Description	Protein FAM5A precursor (Deleted in bladder cancer 1 protein).

FAM5A_MOUSE
NC score	0.019491 (rank : 248)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q920P3, Q80ZL2, Q812F0, Q8C1C9, Q920P4, Q9QXL0	Gene names	Fam5a, Brinp, Brinp1, Dbccr1
Domain Architecture	No domain graphic available
Description	Protein FAM5A precursor (Deleted in bladder cancer 1 protein homolog) (BMP/retinoic acid-inducible neural-specific protein 1).

TNAP3_MOUSE
NC score	0.015086 (rank : 249)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	35	Shared Neighborhood Hits	8
SwissProt Accessions	Q60769	Gene names	Tnfaip3, Tnfip3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

SYTL3_MOUSE
NC score	0.006881 (rank : 250)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

NUAK2_HUMAN
NC score	0.004536 (rank : 251)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	874	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).