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Network neighborhood for query Sequence : FURIN_MOUSE

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FURIN_MOUSE
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FURIN_HUMAN
θ value	0 (rank : 1)	NC score	0.998706 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	43
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCSK4_HUMAN
θ value	0 (rank : 3)	NC score	0.990565 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
θ value	0 (rank : 4)	NC score	0.986491 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

PCSK5_MOUSE
θ value	0 (rank : 5)	NC score	0.745217 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	613	Shared Neighborhood Hits	42
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK6_HUMAN
θ value	0 (rank : 6)	NC score	0.904758 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
θ value	5.00115e-184 (rank : 7)	NC score	0.892481 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

NEC1_HUMAN
θ value	4.26331e-159 (rank : 8)	NC score	0.977727 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
θ value	1.24043e-158 (rank : 9)	NC score	0.978216 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC2_HUMAN
θ value	9.22056e-146 (rank : 10)	NC score	0.975812 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
θ value	6.60789e-144 (rank : 11)	NC score	0.975830 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_MOUSE
θ value	5.84277e-108 (rank : 12)	NC score	0.961502 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK7_HUMAN
θ value	4.94618e-107 (rank : 13)	NC score	0.961647 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

FRAS1_MOUSE
θ value	1.53129e-07 (rank : 14)	NC score	0.176082 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	747	Shared Neighborhood Hits	31
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
θ value	2.88788e-06 (rank : 15)	NC score	0.174538 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	759	Shared Neighborhood Hits	32
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO2_MOUSE
θ value	0.0431538 (rank : 16)	NC score	0.174712 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	0.0736092 (rank : 17)	NC score	0.178319 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

TNR1B_MOUSE
θ value	0.0736092 (rank : 18)	NC score	0.080394 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	123	Shared Neighborhood Hits	13
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

TNR1B_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.063628 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

ERBB2_MOUSE
θ value	0.125558 (rank : 20)	NC score	0.041151 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	918	Shared Neighborhood Hits	21
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

RSPO2_HUMAN
θ value	0.125558 (rank : 21)	NC score	0.171584 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO4_MOUSE
θ value	0.163984 (rank : 22)	NC score	0.177752 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

IGF1R_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.032966 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	977	Shared Neighborhood Hits	26
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

RSPO3_MOUSE
θ value	0.279714 (rank : 24)	NC score	0.175785 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	120	Shared Neighborhood Hits	25
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

ERBB3_MOUSE
θ value	0.365318 (rank : 25)	NC score	0.046314 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	898	Shared Neighborhood Hits	24
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

IGF1R_MOUSE
θ value	0.365318 (rank : 26)	NC score	0.033717 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	973	Shared Neighborhood Hits	26
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

SPG20_HUMAN
θ value	0.365318 (rank : 27)	NC score	0.035578 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0X7, O60349, Q86Y67, Q9H1T2, Q9H1T3	Gene names	SPG20, KIAA0610, TAHCCP1
Domain Architecture	No domain graphic available
Description	Spartin (Trans-activated by hepatitis C virus core protein 1).

CREL1_HUMAN
θ value	0.47712 (rank : 28)	NC score	0.089695 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	441	Shared Neighborhood Hits	23
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

ERBB2_HUMAN
θ value	0.47712 (rank : 29)	NC score	0.038929 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	1073	Shared Neighborhood Hits	20
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ZAN_MOUSE
θ value	0.47712 (rank : 30)	NC score	0.063901 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

INSR_MOUSE
θ value	0.62314 (rank : 31)	NC score	0.028930 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	968	Shared Neighborhood Hits	26
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

CREL1_MOUSE
θ value	1.06291 (rank : 32)	NC score	0.090393 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	524	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

ERBB3_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.045879 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	918	Shared Neighborhood Hits	24
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

RSPO4_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.170413 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

AXN2_MOUSE
θ value	1.81305 (rank : 35)	NC score	0.010176 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

EGFR_HUMAN
θ value	2.36792 (rank : 36)	NC score	0.035329 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	939	Shared Neighborhood Hits	22
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.036349 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	927	Shared Neighborhood Hits	26
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

INSR_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.027357 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	963	Shared Neighborhood Hits	26
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

RSPO1_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.163338 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	101	Shared Neighborhood Hits	22
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

TNR11_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.027065 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	121	Shared Neighborhood Hits	9
SwissProt Accessions	O35305, Q8VCT7	Gene names	Tnfrsf11a, Rank
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR).

ERBB4_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.040345 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	910	Shared Neighborhood Hits	24
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

HECD1_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.005469 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	371	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

BT2A3_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.005192 (rank : 61)
Query Neighborhood Hits	49	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

CAF1A_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.002287 (rank : 63)
Query Neighborhood Hits	49	Target Neighborhood Hits	736	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

PCSK9_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.056875 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

ATBF1_MOUSE
θ value	8.99809 (rank : 46)	NC score	-0.001416 (rank : 64)
Query Neighborhood Hits	49	Target Neighborhood Hits	1841	Shared Neighborhood Hits	4
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

GNDS_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.003513 (rank : 62)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

MBTP1_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.081478 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	8.99809 (rank : 49)	NC score	0.075993 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

CRIM1_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.061757 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	362	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA51_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.062716 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	288	Shared Neighborhood Hits	8
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.061008 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	236	Shared Neighborhood Hits	9
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA53_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.053111 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	331	Shared Neighborhood Hits	16
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA54_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.059153 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	270	Shared Neighborhood Hits	11
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.072104 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	257	Shared Neighborhood Hits	11
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA59_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.067409 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	310	Shared Neighborhood Hits	14
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

MEGF9_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.052542 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	557	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MEGF9_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.056535 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	896	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

RSPO1_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.148483 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

TNR16_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.055527 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TNR16_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.050048 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	178	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

TNR1A_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.054475 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR25_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.054045 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	172	Shared Neighborhood Hits	10
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

TNR9_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.051020 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

Hits sorted by NC score

FURIN_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

FURIN_HUMAN
NC score	0.998706 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	43
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

PCSK4_HUMAN
NC score	0.990565 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
NC score	0.986491 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

NEC1_MOUSE
NC score	0.978216 (rank : 5)	θ value	1.24043e-158 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	16	Shared Neighborhood Hits	15
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC1_HUMAN
NC score	0.977727 (rank : 6)	θ value	4.26331e-159 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_MOUSE
NC score	0.975830 (rank : 7)	θ value	6.60789e-144 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_HUMAN
NC score	0.975812 (rank : 8)	θ value	9.22056e-146 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_HUMAN
NC score	0.961647 (rank : 9)	θ value	4.94618e-107 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.961502 (rank : 10)	θ value	5.84277e-108 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK6_HUMAN
NC score	0.904758 (rank : 11)	θ value	0 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
NC score	0.892481 (rank : 12)	θ value	5.00115e-184 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.745217 (rank : 13)	θ value	0 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	613	Shared Neighborhood Hits	42
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

RSPO3_HUMAN
NC score	0.178319 (rank : 14)	θ value	0.0736092 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO4_MOUSE
NC score	0.177752 (rank : 15)	θ value	0.163984 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

FRAS1_MOUSE
NC score	0.176082 (rank : 16)	θ value	1.53129e-07 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	747	Shared Neighborhood Hits	31
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO3_MOUSE
NC score	0.175785 (rank : 17)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	120	Shared Neighborhood Hits	25
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO2_MOUSE
NC score	0.174712 (rank : 18)	θ value	0.0431538 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

FRAS1_HUMAN
NC score	0.174538 (rank : 19)	θ value	2.88788e-06 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	759	Shared Neighborhood Hits	32
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO2_HUMAN
NC score	0.171584 (rank : 20)	θ value	0.125558 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO4_HUMAN
NC score	0.170413 (rank : 21)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	110	Shared Neighborhood Hits	22
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO1_HUMAN
NC score	0.163338 (rank : 22)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	101	Shared Neighborhood Hits	22
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
NC score	0.148483 (rank : 23)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

CREL1_MOUSE
NC score	0.090393 (rank : 24)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	524	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_HUMAN
NC score	0.089695 (rank : 25)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	441	Shared Neighborhood Hits	23
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

MBTP1_HUMAN
NC score	0.081478 (rank : 26)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

TNR1B_MOUSE
NC score	0.080394 (rank : 27)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	123	Shared Neighborhood Hits	13
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

MBTP1_MOUSE
NC score	0.075993 (rank : 28)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

KRA55_HUMAN
NC score	0.072104 (rank : 29)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	257	Shared Neighborhood Hits	11
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA59_HUMAN
NC score	0.067409 (rank : 30)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	310	Shared Neighborhood Hits	14
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

ZAN_MOUSE
NC score	0.063901 (rank : 31)	θ value	0.47712 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

TNR1B_HUMAN
NC score	0.063628 (rank : 32)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	127	Shared Neighborhood Hits	8
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

KRA51_HUMAN
NC score	0.062716 (rank : 33)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	288	Shared Neighborhood Hits	8
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

CRIM1_HUMAN
NC score	0.061757 (rank : 34)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	362	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA52_HUMAN
NC score	0.061008 (rank : 35)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	236	Shared Neighborhood Hits	9
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA54_HUMAN
NC score	0.059153 (rank : 36)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	270	Shared Neighborhood Hits	11
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

PCSK9_HUMAN
NC score	0.056875 (rank : 37)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

MEGF9_MOUSE
NC score	0.056535 (rank : 38)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	896	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

TNR16_HUMAN
NC score	0.055527 (rank : 39)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	183	Shared Neighborhood Hits	10
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TNR1A_MOUSE
NC score	0.054475 (rank : 40)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	49	Target Neighborhood Hits	131	Shared Neighborhood Hits	11
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR25_HUMAN
NC score	0.054045 (rank : 41)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	49	Target Neighborhood Hits	172	Shared Neighborhood Hits	10
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

KRA53_HUMAN
NC score	0.053111 (rank : 42)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	331	Shared Neighborhood Hits	16
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

MEGF9_HUMAN
NC score	0.052542 (rank : 43)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	557	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

TNR9_MOUSE
NC score	0.051020 (rank : 44)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	49	Target Neighborhood Hits	137	Shared Neighborhood Hits	10
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

TNR16_MOUSE
NC score	0.050048 (rank : 45)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	49	Target Neighborhood Hits	178	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

ERBB3_MOUSE
NC score	0.046314 (rank : 46)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	898	Shared Neighborhood Hits	24
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB3_HUMAN
NC score	0.045879 (rank : 47)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	918	Shared Neighborhood Hits	24
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_MOUSE
NC score	0.041151 (rank : 48)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	918	Shared Neighborhood Hits	21
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB4_HUMAN
NC score	0.040345 (rank : 49)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	910	Shared Neighborhood Hits	24
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERBB2_HUMAN
NC score	0.038929 (rank : 50)	θ value	0.47712 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	1073	Shared Neighborhood Hits	20
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EGFR_MOUSE
NC score	0.036349 (rank : 51)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	927	Shared Neighborhood Hits	26
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

SPG20_HUMAN
NC score	0.035578 (rank : 52)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0X7, O60349, Q86Y67, Q9H1T2, Q9H1T3	Gene names	SPG20, KIAA0610, TAHCCP1
Domain Architecture	No domain graphic available
Description	Spartin (Trans-activated by hepatitis C virus core protein 1).

EGFR_HUMAN
NC score	0.035329 (rank : 53)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	939	Shared Neighborhood Hits	22
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

IGF1R_MOUSE
NC score	0.033717 (rank : 54)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	973	Shared Neighborhood Hits	26
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_HUMAN
NC score	0.032966 (rank : 55)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	977	Shared Neighborhood Hits	26
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSR_MOUSE
NC score	0.028930 (rank : 56)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	968	Shared Neighborhood Hits	26
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_HUMAN
NC score	0.027357 (rank : 57)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	963	Shared Neighborhood Hits	26
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TNR11_MOUSE
NC score	0.027065 (rank : 58)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	121	Shared Neighborhood Hits	9
SwissProt Accessions	O35305, Q8VCT7	Gene names	Tnfrsf11a, Rank
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR).

AXN2_MOUSE
NC score	0.010176 (rank : 59)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

HECD1_HUMAN
NC score	0.005469 (rank : 60)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	371	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

BT2A3_HUMAN
NC score	0.005192 (rank : 61)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

GNDS_MOUSE
NC score	0.003513 (rank : 62)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

CAF1A_MOUSE
NC score	0.002287 (rank : 63)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	736	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

ATBF1_MOUSE
NC score	-0.001416 (rank : 64)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	1841	Shared Neighborhood Hits	4
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).