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Network neighborhood for query Sequence : PCSK4_HUMAN

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PCSK4_HUMAN
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FURIN_HUMAN
θ value	0 (rank : 1)	NC score	0.990148 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	0 (rank : 2)	NC score	0.990565 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

PCSK4_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
θ value	0 (rank : 4)	NC score	0.995665 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

PCSK5_HUMAN
θ value	2.17943e-171 (rank : 5)	NC score	0.879181 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	291	Shared Neighborhood Hits	25
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
θ value	2.17943e-171 (rank : 6)	NC score	0.731285 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	613	Shared Neighborhood Hits	26
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK6_HUMAN
θ value	2.49359e-167 (rank : 7)	NC score	0.890260 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	298	Shared Neighborhood Hits	26
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

NEC1_HUMAN
θ value	1.01709e-152 (rank : 8)	NC score	0.981065 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC1_MOUSE
θ value	2.26584e-152 (rank : 9)	NC score	0.981762 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC2_HUMAN
θ value	2.689e-137 (rank : 10)	NC score	0.978913 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_MOUSE
θ value	2.689e-137 (rank : 11)	NC score	0.978991 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_MOUSE
θ value	9.94316e-116 (rank : 12)	NC score	0.968075 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK7_HUMAN
θ value	9.30652e-114 (rank : 13)	NC score	0.968167 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

FRAS1_HUMAN
θ value	3.77169e-06 (rank : 14)	NC score	0.155908 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	759	Shared Neighborhood Hits	19
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
θ value	0.000158464 (rank : 15)	NC score	0.156678 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

TNR1B_MOUSE
θ value	0.0563607 (rank : 16)	NC score	0.069109 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	123	Shared Neighborhood Hits	13
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

EGFR_MOUSE
θ value	0.365318 (rank : 17)	NC score	0.025320 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	927	Shared Neighborhood Hits	17
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ERBB4_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.029301 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	910	Shared Neighborhood Hits	16
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

PGBM_MOUSE
θ value	1.38821 (rank : 19)	NC score	0.021387 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	1073	Shared Neighborhood Hits	15
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CREL1_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.081868 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	524	Shared Neighborhood Hits	18
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

NETR_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.004172 (rank : 53)
Query Neighborhood Hits	32	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

VACHT_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.012328 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q16572	Gene names	SLC18A3, VACHT
Domain Architecture
Description	Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3).

LAMA2_HUMAN
θ value	2.36792 (rank : 23)	NC score	0.027112 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	1092	Shared Neighborhood Hits	16
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

PI5PA_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.004490 (rank : 52)
Query Neighborhood Hits	32	Target Neighborhood Hits	749	Shared Neighborhood Hits	2
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

NETR_MOUSE
θ value	5.27518 (rank : 25)	NC score	0.002505 (rank : 54)
Query Neighborhood Hits	32	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).

PFTB_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.009060 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P49356	Gene names	FNTB
Domain Architecture
Description	Protein farnesyltransferase subunit beta (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) (FTase-beta).

TNR21_HUMAN
θ value	5.27518 (rank : 27)	NC score	0.031969 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	O75509, Q96D86	Gene names	TNFRSF21, DR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

ERBB3_MOUSE
θ value	6.88961 (rank : 28)	NC score	0.033199 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	898	Shared Neighborhood Hits	14
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

SSPO_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.024251 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	800	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

CREL1_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.080952 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	441	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

KALM_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.018956 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

ZAN_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.056696 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	808	Shared Neighborhood Hits	19
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

CRIM1_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.057329 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	362	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA51_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.060265 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.056936 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA54_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.055386 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.067736 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	257	Shared Neighborhood Hits	12
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA59_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.063720 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	310	Shared Neighborhood Hits	12
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

MBTP1_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.073568 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

MBTP1_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.068365 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

MEGF9_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.051192 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	557	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MEGF9_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.055541 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	896	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

PCSK9_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.050471 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

RSPO1_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.116722 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	12
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.103935 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.117085 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.120105 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.124710 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	128	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.122770 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.120094 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.125863 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

TNR16_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.051268 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	183	Shared Neighborhood Hits	12
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TNR1A_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.050465 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR1B_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.050619 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

Hits sorted by NC score

PCSK4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PCSK4_MOUSE
NC score	0.995665 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	15
SwissProt Accessions	P29121, Q62094	Gene names	Pcsk4, Nec-3, Nec3
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (PC4) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) (KEX2-like endoprotease 3).

FURIN_MOUSE
NC score	0.990565 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

FURIN_HUMAN
NC score	0.990148 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

NEC1_MOUSE
NC score	0.981762 (rank : 5)	θ value	2.26584e-152 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P63239, P21662, P22546	Gene names	Pcsk1, Att-1, Nec-1, Nec1
Domain Architecture	No domain graphic available
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) (PC3) (Furin homolog) (Propeptide-processing protease).

NEC1_HUMAN
NC score	0.981065 (rank : 6)	θ value	1.01709e-152 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	P29120, P78478, Q92532	Gene names	PCSK1, NEC1
Domain Architecture
Description	Neuroendocrine convertase 1 precursor (EC 3.4.21.93) (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1).

NEC2_MOUSE
NC score	0.978991 (rank : 7)	θ value	2.689e-137 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P21661, Q80WU1	Gene names	Pcsk2, Nec-2, Nec2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

NEC2_HUMAN
NC score	0.978913 (rank : 8)	θ value	2.689e-137 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	P16519, Q14927, Q9NQG3, Q9NUG1, Q9UJC6	Gene names	PCSK2, NEC2
Domain Architecture
Description	Neuroendocrine convertase 2 precursor (EC 3.4.21.94) (NEC 2) (PC2) (Prohormone convertase 2) (Proprotein convertase 2) (KEX2-like endoprotease 2).

PCSK7_HUMAN
NC score	0.968167 (rank : 9)	θ value	9.30652e-114 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q16549, Q9UL57	Gene names	PCSK7, LPC, PC7, PC8, SPC7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (PC8) (hPC8) (Lymphoma proprotein convertase).

PCSK7_MOUSE
NC score	0.968075 (rank : 10)	θ value	9.94316e-116 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q61139, O08577	Gene names	Pcsk7, Pc7
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 7 precursor (EC 3.4.21.-) (Proprotein convertase PC7) (Subtilisin/kexin-like protease PC7) (Prohormone convertase PC7) (Subtilisin-like proprotein convertase 7) (SPC7).

PCSK6_HUMAN
NC score	0.890260 (rank : 11)	θ value	2.49359e-167 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	298	Shared Neighborhood Hits	26
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

PCSK5_HUMAN
NC score	0.879181 (rank : 12)	θ value	2.17943e-171 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	291	Shared Neighborhood Hits	25
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
NC score	0.731285 (rank : 13)	θ value	2.17943e-171 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	613	Shared Neighborhood Hits	26
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

FRAS1_MOUSE
NC score	0.156678 (rank : 14)	θ value	0.000158464 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.155908 (rank : 15)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	759	Shared Neighborhood Hits	19
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RSPO4_MOUSE
NC score	0.125863 (rank : 16)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	32	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

RSPO3_HUMAN
NC score	0.124710 (rank : 17)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	32	Target Neighborhood Hits	128	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
NC score	0.122770 (rank : 18)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	32	Target Neighborhood Hits	120	Shared Neighborhood Hits	14
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO2_MOUSE
NC score	0.120105 (rank : 19)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	32	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO4_HUMAN
NC score	0.120094 (rank : 20)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	32	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO2_HUMAN
NC score	0.117085 (rank : 21)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO1_HUMAN
NC score	0.116722 (rank : 22)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	32	Target Neighborhood Hits	101	Shared Neighborhood Hits	12
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
NC score	0.103935 (rank : 23)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	32	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

CREL1_MOUSE
NC score	0.081868 (rank : 24)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	524	Shared Neighborhood Hits	18
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_HUMAN
NC score	0.080952 (rank : 25)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	441	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

MBTP1_HUMAN
NC score	0.073568 (rank : 26)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	32	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q14703, Q9UF67	Gene names	MBTPS1, KIAA0091, S1P, SKI1
Domain Architecture	No domain graphic available
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin- isozyme 1) (SKI-1).

TNR1B_MOUSE
NC score	0.069109 (rank : 27)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	123	Shared Neighborhood Hits	13
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

MBTP1_MOUSE
NC score	0.068365 (rank : 28)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

KRA55_HUMAN
NC score	0.067736 (rank : 29)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	32	Target Neighborhood Hits	257	Shared Neighborhood Hits	12
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA59_HUMAN
NC score	0.063720 (rank : 30)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	32	Target Neighborhood Hits	310	Shared Neighborhood Hits	12
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KRA51_HUMAN
NC score	0.060265 (rank : 31)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

CRIM1_HUMAN
NC score	0.057329 (rank : 32)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	362	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA52_HUMAN
NC score	0.056936 (rank : 33)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	32	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

ZAN_MOUSE
NC score	0.056696 (rank : 34)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	808	Shared Neighborhood Hits	19
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

MEGF9_MOUSE
NC score	0.055541 (rank : 35)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	32	Target Neighborhood Hits	896	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

KRA54_HUMAN
NC score	0.055386 (rank : 36)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	32	Target Neighborhood Hits	270	Shared Neighborhood Hits	13
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

TNR16_HUMAN
NC score	0.051268 (rank : 37)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	32	Target Neighborhood Hits	183	Shared Neighborhood Hits	12
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

MEGF9_HUMAN
NC score	0.051192 (rank : 38)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	32	Target Neighborhood Hits	557	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

TNR1B_HUMAN
NC score	0.050619 (rank : 39)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	32	Target Neighborhood Hits	127	Shared Neighborhood Hits	7
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

PCSK9_HUMAN
NC score	0.050471 (rank : 40)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	32	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NBP7, Q5PSM5	Gene names	PCSK9, NARC1
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 9 precursor (EC 3.4.21.-) (Proprotein convertase PC9) (Subtilisin/kexin-like protease PC9) (Neural apoptosis-regulated convertase 1) (NARC-1).

TNR1A_MOUSE
NC score	0.050465 (rank : 41)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	32	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

ERBB3_MOUSE
NC score	0.033199 (rank : 42)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	898	Shared Neighborhood Hits	14
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

TNR21_HUMAN
NC score	0.031969 (rank : 43)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	O75509, Q96D86	Gene names	TNFRSF21, DR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

ERBB4_HUMAN
NC score	0.029301 (rank : 44)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	910	Shared Neighborhood Hits	16
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

LAMA2_HUMAN
NC score	0.027112 (rank : 45)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	1092	Shared Neighborhood Hits	16
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

EGFR_MOUSE
NC score	0.025320 (rank : 46)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	927	Shared Neighborhood Hits	17
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

SSPO_MOUSE
NC score	0.024251 (rank : 47)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	800	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

PGBM_MOUSE
NC score	0.021387 (rank : 48)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	1073	Shared Neighborhood Hits	15
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KALM_HUMAN
NC score	0.018956 (rank : 49)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

VACHT_HUMAN
NC score	0.012328 (rank : 50)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q16572	Gene names	SLC18A3, VACHT
Domain Architecture
Description	Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3).

PFTB_HUMAN
NC score	0.009060 (rank : 51)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P49356	Gene names	FNTB
Domain Architecture
Description	Protein farnesyltransferase subunit beta (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) (FTase-beta).

PI5PA_HUMAN
NC score	0.004490 (rank : 52)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	749	Shared Neighborhood Hits	2
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

NETR_HUMAN
NC score	0.004172 (rank : 53)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	P56730, Q9UP16	Gene names	PRSS12
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).

NETR_MOUSE
NC score	0.002505 (rank : 54)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	O08762	Gene names	Prss12, Bssp3
Domain Architecture
Description	Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Brain-specific serine protease 3) (BSSP-3).