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Network neighborhood for query Sequence : TNR1A_MOUSE

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TNR1A_MOUSE
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TNR1A_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	131	Target Neighborhood Hits	131	Shared Neighborhood Hits	131
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR1A_HUMAN
θ value	6.40027e-139 (rank : 2)	NC score	0.944092 (rank : 2)
Query Neighborhood Hits	131	Target Neighborhood Hits	121	Shared Neighborhood Hits	67
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

TNR25_HUMAN
θ value	8.93572e-24 (rank : 3)	NC score	0.749053 (rank : 6)
Query Neighborhood Hits	131	Target Neighborhood Hits	172	Shared Neighborhood Hits	62
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

TNR22_MOUSE
θ value	5.25075e-16 (rank : 4)	NC score	0.761237 (rank : 4)
Query Neighborhood Hits	131	Target Neighborhood Hits	97	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ER62, Q8VHB9, Q9CZA4	Gene names	Tnfrsf22, Dctrailr2, Tnfrh2, Tnfrsf1al2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2).

TNR23_MOUSE
θ value	6.85773e-16 (rank : 5)	NC score	0.753967 (rank : 5)
Query Neighborhood Hits	131	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ER63, Q8VHC0	Gene names	Tnfrsf23, Dctrailr1, Tnfrh1, Tnfrsf1al1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 23 precursor (Tumor necrosis factor receptor p60 homolog 1) (TNF receptor family member SOB) (Decoy TRAIL receptor 1) (TNF receptor homolog 1).

TNR3_HUMAN
θ value	4.44505e-15 (rank : 6)	NC score	0.707092 (rank : 7)
Query Neighborhood Hits	131	Target Neighborhood Hits	145	Shared Neighborhood Hits	64
SwissProt Accessions	P36941	Gene names	LTBR, TNFCR, TNFRSF3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor C receptor).

TNR26_MOUSE
θ value	3.76295e-14 (rank : 7)	NC score	0.762696 (rank : 3)
Query Neighborhood Hits	131	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	P83626	Gene names	Tnfrsf26, Tnfrh3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 26 precursor (TNF receptor homolog 3).

TNR5_MOUSE
θ value	5.43371e-13 (rank : 8)	NC score	0.667543 (rank : 12)
Query Neighborhood Hits	131	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

TNR16_MOUSE
θ value	9.26847e-13 (rank : 9)	NC score	0.642687 (rank : 17)
Query Neighborhood Hits	131	Target Neighborhood Hits	178	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

TNR3_MOUSE
θ value	9.26847e-13 (rank : 10)	NC score	0.675719 (rank : 10)
Query Neighborhood Hits	131	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	P50284	Gene names	Ltbr, Tnfcr, Tnfrsf3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor).

TNR6_MOUSE
θ value	1.58096e-12 (rank : 11)	NC score	0.689120 (rank : 9)
Query Neighborhood Hits	131	Target Neighborhood Hits	99	Shared Neighborhood Hits	49
SwissProt Accessions	P25446, Q9DCQ1	Gene names	Fas, Apt1, Tnfrsf6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

TNR1B_HUMAN
θ value	1.9326e-10 (rank : 12)	NC score	0.667973 (rank : 11)
Query Neighborhood Hits	131	Target Neighborhood Hits	127	Shared Neighborhood Hits	58
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

TR11B_HUMAN
θ value	1.9326e-10 (rank : 13)	NC score	0.653094 (rank : 14)
Query Neighborhood Hits	131	Target Neighborhood Hits	92	Shared Neighborhood Hits	57
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

TNR1B_MOUSE
θ value	2.52405e-10 (rank : 14)	NC score	0.656080 (rank : 13)
Query Neighborhood Hits	131	Target Neighborhood Hits	123	Shared Neighborhood Hits	52
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

TNR14_HUMAN
θ value	3.29651e-10 (rank : 15)	NC score	0.697925 (rank : 8)
Query Neighborhood Hits	131	Target Neighborhood Hits	149	Shared Neighborhood Hits	64
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

TR11B_MOUSE
θ value	1.06045e-08 (rank : 16)	NC score	0.647886 (rank : 15)
Query Neighborhood Hits	131	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	O08712, O70202	Gene names	Tnfrsf11b, Ocif, Opg
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

TNR5_HUMAN
θ value	8.97725e-08 (rank : 17)	NC score	0.646147 (rank : 16)
Query Neighborhood Hits	131	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	P25942, Q9BYU0	Gene names	CD40, TNFRSF5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (CDw40) (Bp50).

TNR4_MOUSE
θ value	1.17247e-07 (rank : 18)	NC score	0.631182 (rank : 18)
Query Neighborhood Hits	131	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	P47741	Gene names	Tnfrsf4, Ox40, Txgp1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (OX40 antigen).

TNR11_MOUSE
θ value	1.53129e-07 (rank : 19)	NC score	0.600193 (rank : 22)
Query Neighborhood Hits	131	Target Neighborhood Hits	121	Shared Neighborhood Hits	61
SwissProt Accessions	O35305, Q8VCT7	Gene names	Tnfrsf11a, Rank
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR).

TNR21_MOUSE
θ value	9.92553e-07 (rank : 20)	NC score	0.542818 (rank : 28)
Query Neighborhood Hits	131	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EPU5, Q91W77, Q91XH9	Gene names	Tnfrsf21, Dr6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

TNR4_HUMAN
θ value	9.92553e-07 (rank : 21)	NC score	0.596159 (rank : 24)
Query Neighborhood Hits	131	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

TNR21_HUMAN
θ value	1.69304e-06 (rank : 22)	NC score	0.544995 (rank : 27)
Query Neighborhood Hits	131	Target Neighborhood Hits	90	Shared Neighborhood Hits	48
SwissProt Accessions	O75509, Q96D86	Gene names	TNFRSF21, DR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

TNR7_MOUSE
θ value	1.69304e-06 (rank : 23)	NC score	0.580692 (rank : 26)
Query Neighborhood Hits	131	Target Neighborhood Hits	112	Shared Neighborhood Hits	51
SwissProt Accessions	P41272	Gene names	Tnfrsf7, Cd27
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27).

TNR7_HUMAN
θ value	3.77169e-06 (rank : 24)	NC score	0.597659 (rank : 23)
Query Neighborhood Hits	131	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	P26842	Gene names	TNFRSF7, CD27
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27) (T14).

TNR11_HUMAN
θ value	8.40245e-06 (rank : 25)	NC score	0.582414 (rank : 25)
Query Neighborhood Hits	131	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

TNR27_HUMAN
θ value	8.40245e-06 (rank : 26)	NC score	0.422716 (rank : 37)
Query Neighborhood Hits	131	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HAV5, Q6UWM2, Q8IZA6	Gene names	EDA2R, TNFRSF27, XEDAR
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

TNR6_HUMAN
θ value	8.40245e-06 (rank : 27)	NC score	0.618694 (rank : 19)
Query Neighborhood Hits	131	Target Neighborhood Hits	95	Shared Neighborhood Hits	52
SwissProt Accessions	P25445, Q14292, Q14293, Q14294, Q14295, Q16652, Q6SSE9	Gene names	FAS, APT1, FAS1, TNFRSF6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

TNR8_HUMAN
θ value	8.40245e-06 (rank : 28)	NC score	0.529262 (rank : 30)
Query Neighborhood Hits	131	Target Neighborhood Hits	198	Shared Neighborhood Hits	65
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

TR10C_HUMAN
θ value	7.1131e-05 (rank : 29)	NC score	0.536884 (rank : 29)
Query Neighborhood Hits	131	Target Neighborhood Hits	105	Shared Neighborhood Hits	41
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

TNR19_HUMAN
θ value	9.29e-05 (rank : 30)	NC score	0.335793 (rank : 41)
Query Neighborhood Hits	131	Target Neighborhood Hits	89	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS68, Q9BXZ9, Q9BY00, Q9NZV2	Gene names	TNFRSF19, TAJ, TROY
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

TNR19_MOUSE
θ value	0.000121331 (rank : 31)	NC score	0.380170 (rank : 40)
Query Neighborhood Hits	131	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLL3, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7	Gene names	Tnfrsf19, Taj, Troy
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

TR10B_HUMAN
θ value	0.000121331 (rank : 32)	NC score	0.500812 (rank : 31)
Query Neighborhood Hits	131	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	O14763, O14720, O15508, O15517, O15531, Q9BVE0	Gene names	TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD262 antigen).

TNR16_HUMAN
θ value	0.00020696 (rank : 33)	NC score	0.600368 (rank : 21)
Query Neighborhood Hits	131	Target Neighborhood Hits	183	Shared Neighborhood Hits	71
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TR10A_HUMAN
θ value	0.00020696 (rank : 34)	NC score	0.467072 (rank : 34)
Query Neighborhood Hits	131	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	O00220, Q96E62	Gene names	TNFRSF10A, APO2, DR4, TRAILR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10A precursor (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD261 antigen).

TR10D_HUMAN
θ value	0.00035302 (rank : 35)	NC score	0.481651 (rank : 32)
Query Neighborhood Hits	131	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBN6, Q9Y6Q4	Gene names	TNFRSF10D, DCR2, TRAILR4, TRUNDD
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10D precursor (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD264 antigen).

TNR27_MOUSE
θ value	0.000461057 (rank : 36)	NC score	0.380972 (rank : 39)
Query Neighborhood Hits	131	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX35, Q8BM50	Gene names	Eda2r, Tnfrsf27, Xedar
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

PCSK5_HUMAN
θ value	0.00134147 (rank : 37)	NC score	0.137547 (rank : 48)
Query Neighborhood Hits	131	Target Neighborhood Hits	291	Shared Neighborhood Hits	66
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK6_HUMAN
θ value	0.00134147 (rank : 38)	NC score	0.123868 (rank : 50)
Query Neighborhood Hits	131	Target Neighborhood Hits	298	Shared Neighborhood Hits	58
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

HGFA_MOUSE
θ value	0.00228821 (rank : 39)	NC score	0.028081 (rank : 190)
Query Neighborhood Hits	131	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

TR10B_MOUSE
θ value	0.00228821 (rank : 40)	NC score	0.476874 (rank : 33)
Query Neighborhood Hits	131	Target Neighborhood Hits	76	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

TR19L_MOUSE
θ value	0.00390308 (rank : 41)	NC score	0.300932 (rank : 42)
Query Neighborhood Hits	131	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX43, Q8BTV0	Gene names	Tnfrsf19l
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 19L precursor.

TNR6B_HUMAN
θ value	0.00665767 (rank : 42)	NC score	0.612312 (rank : 20)
Query Neighborhood Hits	131	Target Neighborhood Hits	103	Shared Neighborhood Hits	56
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

DLL4_MOUSE
θ value	0.0113563 (rank : 43)	NC score	0.078994 (rank : 82)
Query Neighborhood Hits	131	Target Neighborhood Hits	440	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

FADD_MOUSE
θ value	0.0252991 (rank : 44)	NC score	0.110716 (rank : 55)
Query Neighborhood Hits	131	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

USH2A_MOUSE
θ value	0.0252991 (rank : 45)	NC score	0.093691 (rank : 65)
Query Neighborhood Hits	131	Target Neighborhood Hits	626	Shared Neighborhood Hits	65
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

FHL2_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.049565 (rank : 178)
Query Neighborhood Hits	131	Target Neighborhood Hits	539	Shared Neighborhood Hits	36
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

PCSK5_MOUSE
θ value	0.0736092 (rank : 47)	NC score	0.174865 (rank : 45)
Query Neighborhood Hits	131	Target Neighborhood Hits	613	Shared Neighborhood Hits	93
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

TRI59_MOUSE
θ value	0.0961366 (rank : 48)	NC score	0.022930 (rank : 193)
Query Neighborhood Hits	131	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

DLL4_HUMAN
θ value	0.125558 (rank : 49)	NC score	0.077395 (rank : 83)
Query Neighborhood Hits	131	Target Neighborhood Hits	435	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

ERBB4_HUMAN
θ value	0.125558 (rank : 50)	NC score	0.009254 (rank : 216)
Query Neighborhood Hits	131	Target Neighborhood Hits	910	Shared Neighborhood Hits	18
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ZN224_HUMAN
θ value	0.125558 (rank : 51)	NC score	0.010572 (rank : 212)
Query Neighborhood Hits	131	Target Neighborhood Hits	808	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).

DLL1_MOUSE
θ value	0.163984 (rank : 52)	NC score	0.072984 (rank : 90)
Query Neighborhood Hits	131	Target Neighborhood Hits	456	Shared Neighborhood Hits	51
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

FBLN5_HUMAN
θ value	0.163984 (rank : 53)	NC score	0.067333 (rank : 99)
Query Neighborhood Hits	131	Target Neighborhood Hits	329	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

LAMA2_MOUSE
θ value	0.163984 (rank : 54)	NC score	0.077340 (rank : 84)
Query Neighborhood Hits	131	Target Neighborhood Hits	1198	Shared Neighborhood Hits	67
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

TECTA_HUMAN
θ value	0.163984 (rank : 55)	NC score	0.069628 (rank : 96)
Query Neighborhood Hits	131	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

FBLN5_MOUSE
θ value	0.21417 (rank : 56)	NC score	0.063898 (rank : 107)
Query Neighborhood Hits	131	Target Neighborhood Hits	317	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

ZAN_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.111846 (rank : 54)
Query Neighborhood Hits	131	Target Neighborhood Hits	808	Shared Neighborhood Hits	72
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

MEGF9_HUMAN
θ value	0.279714 (rank : 58)	NC score	0.107769 (rank : 57)
Query Neighborhood Hits	131	Target Neighborhood Hits	557	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

FHL2_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.042206 (rank : 183)
Query Neighborhood Hits	131	Target Neighborhood Hits	533	Shared Neighborhood Hits	30
SwissProt Accessions	Q14192, Q13229, Q13644, Q9P294	Gene names	FHL2, DRAL, SLIM3
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3) (LIM-domain protein DRAL).

MATN2_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.065837 (rank : 106)
Query Neighborhood Hits	131	Target Neighborhood Hits	365	Shared Neighborhood Hits	48
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN2_MOUSE
θ value	0.365318 (rank : 61)	NC score	0.063855 (rank : 108)
Query Neighborhood Hits	131	Target Neighborhood Hits	356	Shared Neighborhood Hits	48
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

TR19L_HUMAN
θ value	0.365318 (rank : 62)	NC score	0.261773 (rank : 43)
Query Neighborhood Hits	131	Target Neighborhood Hits	99	Shared Neighborhood Hits	36
SwissProt Accessions	Q969Z4, Q86V34, Q96JU1, Q9BUX7	Gene names	TNFRSF19L, RELT
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19L precursor (Receptor expressed in lymphoid tissues).

ZN473_HUMAN
θ value	0.365318 (rank : 63)	NC score	0.009085 (rank : 217)
Query Neighborhood Hits	131	Target Neighborhood Hits	765	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WTR7, Q9ULS9, Q9Y4Q7	Gene names	ZNF473, KIAA1141, ZFP100
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100).

ANK2_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.013539 (rank : 202)
Query Neighborhood Hits	131	Target Neighborhood Hits	1615	Shared Neighborhood Hits	18
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

FBLI1_HUMAN
θ value	0.47712 (rank : 65)	NC score	0.031352 (rank : 187)
Query Neighborhood Hits	131	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

LAMC3_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.112926 (rank : 51)
Query Neighborhood Hits	131	Target Neighborhood Hits	588	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

TECTA_MOUSE
θ value	0.47712 (rank : 67)	NC score	0.072346 (rank : 91)
Query Neighborhood Hits	131	Target Neighborhood Hits	244	Shared Neighborhood Hits	31
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

ZN155_HUMAN
θ value	0.47712 (rank : 68)	NC score	0.010588 (rank : 211)
Query Neighborhood Hits	131	Target Neighborhood Hits	786	Shared Neighborhood Hits	31
SwissProt Accessions	Q12901, Q9UIE1, Q9UK14	Gene names	ZNF155
Domain Architecture
Description	Zinc finger protein 155.

ZN583_HUMAN
θ value	0.47712 (rank : 69)	NC score	0.008359 (rank : 218)
Query Neighborhood Hits	131	Target Neighborhood Hits	774	Shared Neighborhood Hits	15
SwissProt Accessions	Q96ND8, O14850, Q2NKK3	Gene names	ZNF583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583 (Zinc finger protein L3-5).

DLL1_HUMAN
θ value	0.62314 (rank : 70)	NC score	0.071470 (rank : 94)
Query Neighborhood Hits	131	Target Neighborhood Hits	455	Shared Neighborhood Hits	49
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

EMR1_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.041132 (rank : 184)
Query Neighborhood Hits	131	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

IBRD3_HUMAN
θ value	0.813845 (rank : 72)	NC score	0.029578 (rank : 189)
Query Neighborhood Hits	131	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

TNR8_MOUSE
θ value	0.813845 (rank : 73)	NC score	0.401642 (rank : 38)
Query Neighborhood Hits	131	Target Neighborhood Hits	208	Shared Neighborhood Hits	52
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

TNR9_HUMAN
θ value	0.813845 (rank : 74)	NC score	0.432307 (rank : 36)
Query Neighborhood Hits	131	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q07011	Gene names	TNFRSF9, CD137, ILA
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD137 antigen).

FADD_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.086142 (rank : 73)
Query Neighborhood Hits	131	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

LTBP2_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.061613 (rank : 112)
Query Neighborhood Hits	131	Target Neighborhood Hits	617	Shared Neighborhood Hits	57
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MYCB2_HUMAN
θ value	1.06291 (rank : 77)	NC score	0.037255 (rank : 185)
Query Neighborhood Hits	131	Target Neighborhood Hits	390	Shared Neighborhood Hits	15
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYCB2_MOUSE
θ value	1.06291 (rank : 78)	NC score	0.036766 (rank : 186)
Query Neighborhood Hits	131	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

SSPO_MOUSE
θ value	1.06291 (rank : 79)	NC score	0.071493 (rank : 93)
Query Neighborhood Hits	131	Target Neighborhood Hits	800	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TRAF2_MOUSE
θ value	1.06291 (rank : 80)	NC score	0.018417 (rank : 196)
Query Neighborhood Hits	131	Target Neighborhood Hits	394	Shared Neighborhood Hits	11
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

DHX37_HUMAN
θ value	1.38821 (rank : 81)	NC score	0.015697 (rank : 200)
Query Neighborhood Hits	131	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

LAMA1_MOUSE
θ value	1.38821 (rank : 82)	NC score	0.095940 (rank : 64)
Query Neighborhood Hits	131	Target Neighborhood Hits	838	Shared Neighborhood Hits	78
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA5_HUMAN
θ value	1.38821 (rank : 83)	NC score	0.107850 (rank : 56)
Query Neighborhood Hits	131	Target Neighborhood Hits	976	Shared Neighborhood Hits	82
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

ZAN_HUMAN
θ value	1.38821 (rank : 84)	NC score	0.075415 (rank : 88)
Query Neighborhood Hits	131	Target Neighborhood Hits	679	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ZN460_HUMAN
θ value	1.38821 (rank : 85)	NC score	0.007757 (rank : 220)
Query Neighborhood Hits	131	Target Neighborhood Hits	745	Shared Neighborhood Hits	17
SwissProt Accessions	Q14592, Q6VSF8	Gene names	ZNF460, ZNF272
Domain Architecture	No domain graphic available
Description	Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8).

ADA32_MOUSE
θ value	1.81305 (rank : 86)	NC score	0.009342 (rank : 215)
Query Neighborhood Hits	131	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

FBLI1_MOUSE
θ value	1.81305 (rank : 87)	NC score	0.027656 (rank : 191)
Query Neighborhood Hits	131	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

FRAS1_HUMAN
θ value	1.81305 (rank : 88)	NC score	0.112424 (rank : 52)
Query Neighborhood Hits	131	Target Neighborhood Hits	759	Shared Neighborhood Hits	86
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

LAMC1_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.096144 (rank : 63)
Query Neighborhood Hits	131	Target Neighborhood Hits	922	Shared Neighborhood Hits	66
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMC3_MOUSE
θ value	1.81305 (rank : 90)	NC score	0.111959 (rank : 53)
Query Neighborhood Hits	131	Target Neighborhood Hits	624	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

SCYL2_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.012133 (rank : 206)
Query Neighborhood Hits	131	Target Neighborhood Hits	632	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

USH2A_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.088152 (rank : 70)
Query Neighborhood Hits	131	Target Neighborhood Hits	600	Shared Neighborhood Hits	66
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

ZN583_MOUSE
θ value	1.81305 (rank : 93)	NC score	0.007821 (rank : 219)
Query Neighborhood Hits	131	Target Neighborhood Hits	774	Shared Neighborhood Hits	16
SwissProt Accessions	Q3V080, Q3V3L4	Gene names	Znf583, Zfp583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583.

FBLN3_MOUSE
θ value	2.36792 (rank : 94)	NC score	0.048267 (rank : 180)
Query Neighborhood Hits	131	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

PLXB3_MOUSE
θ value	2.36792 (rank : 95)	NC score	0.013505 (rank : 203)
Query Neighborhood Hits	131	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QY40, Q80TH8	Gene names	Plxnb3, Kiaa1206, Plxn6
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor (Plexin-6).

RNF8_MOUSE
θ value	2.36792 (rank : 96)	NC score	0.011134 (rank : 209)
Query Neighborhood Hits	131	Target Neighborhood Hits	618	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

ANK3_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.016944 (rank : 198)
Query Neighborhood Hits	131	Target Neighborhood Hits	853	Shared Neighborhood Hits	16
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

LAMB2_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.084928 (rank : 74)
Query Neighborhood Hits	131	Target Neighborhood Hits	692	Shared Neighborhood Hits	63
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

MYST4_MOUSE
θ value	3.0926 (rank : 99)	NC score	0.013027 (rank : 205)
Query Neighborhood Hits	131	Target Neighborhood Hits	416	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

RSPO1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.067604 (rank : 98)
Query Neighborhood Hits	131	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

ZN519_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.007513 (rank : 221)
Query Neighborhood Hits	131	Target Neighborhood Hits	738	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TB69	Gene names	ZNF519
Domain Architecture
Description	Zinc finger protein 519.

KR106_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.054359 (rank : 140)
Query Neighborhood Hits	131	Target Neighborhood Hits	347	Shared Neighborhood Hits	45
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

LRP1B_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.042466 (rank : 182)
Query Neighborhood Hits	131	Target Neighborhood Hits	606	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

S23IP_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.013164 (rank : 204)
Query Neighborhood Hits	131	Target Neighborhood Hits	363	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

FBLN3_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.048311 (rank : 179)
Query Neighborhood Hits	131	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FRAS1_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.103477 (rank : 58)
Query Neighborhood Hits	131	Target Neighborhood Hits	747	Shared Neighborhood Hits	84
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

PPRB_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.015173 (rank : 201)
Query Neighborhood Hits	131	Target Neighborhood Hits	311	Shared Neighborhood Hits	5
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

TS1R1_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.007106 (rank : 224)
Query Neighborhood Hits	131	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0	Gene names	TAS1R1, GPR70, T1R1, TR1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70) (Gm148).

ZNF16_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.007067 (rank : 225)
Query Neighborhood Hits	131	Target Neighborhood Hits	771	Shared Neighborhood Hits	19
SwissProt Accessions	P17020, Q96FG0	Gene names	ZNF16, KOX9
Domain Architecture	No domain graphic available
Description	Zinc finger protein 16 (Zinc finger protein KOX9).

ABLM2_MOUSE
θ value	6.88961 (rank : 110)	NC score	0.016747 (rank : 199)
Query Neighborhood Hits	131	Target Neighborhood Hits	306	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BL65, Q6H8P8, Q80WK6, Q8BUT1, Q8BXI7	Gene names	Ablim2
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

C1QR1_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.045145 (rank : 181)
Query Neighborhood Hits	131	Target Neighborhood Hits	493	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

ITB2_HUMAN
θ value	6.88961 (rank : 112)	NC score	0.031180 (rank : 188)
Query Neighborhood Hits	131	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	P05107, Q16418	Gene names	ITGB2, CD18
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

LAMA5_MOUSE
θ value	6.88961 (rank : 113)	NC score	0.102833 (rank : 59)
Query Neighborhood Hits	131	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMB2_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.096387 (rank : 62)
Query Neighborhood Hits	131	Target Neighborhood Hits	722	Shared Neighborhood Hits	66
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

LAMC1_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.090490 (rank : 67)
Query Neighborhood Hits	131	Target Neighborhood Hits	856	Shared Neighborhood Hits	66
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

MFGM_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.026222 (rank : 192)
Query Neighborhood Hits	131	Target Neighborhood Hits	233	Shared Neighborhood Hits	25
SwissProt Accessions	P21956, P97800, Q3TBN5, Q9R1X9, Q9WTS3	Gene names	Mfge8
Domain Architecture
Description	Lactadherin precursor (Milk fat globule-EGF factor 8) (MFG-E8) (MFGM) (Sperm surface protein SP47) (MP47).

PLXB3_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.010671 (rank : 210)
Query Neighborhood Hits	131	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULL4, Q9HDA4	Gene names	PLXNB3, KIAA1206
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor.

SCYL2_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.009714 (rank : 214)
Query Neighborhood Hits	131	Target Neighborhood Hits	603	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

THYG_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.018341 (rank : 197)
Query Neighborhood Hits	131	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

ZN221_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.009838 (rank : 213)
Query Neighborhood Hits	131	Target Neighborhood Hits	784	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UK13, Q9P1U8	Gene names	ZNF221
Domain Architecture
Description	Zinc finger protein 221.

ZN614_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.007331 (rank : 222)
Query Neighborhood Hits	131	Target Neighborhood Hits	752	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N883, Q494T8, Q8TCF4	Gene names	ZNF614
Domain Architecture	No domain graphic available
Description	Zinc finger protein 614.

CCND3_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.006161 (rank : 227)
Query Neighborhood Hits	131	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P30282, Q62391, Q99KP2	Gene names	Ccnd3, Cyl-3
Domain Architecture
Description	G1/S-specific cyclin-D3.

FA10_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.019207 (rank : 195)
Query Neighborhood Hits	131	Target Neighborhood Hits	435	Shared Neighborhood Hits	33
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FCN1_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.001437 (rank : 228)
Query Neighborhood Hits	131	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

GRAM3_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.011845 (rank : 207)
Query Neighborhood Hits	131	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q96HH9, Q9H753	Gene names	GRAMD3, NS3TP2
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3 (HCV NS3-transactivated protein 2).

LAMC2_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.102115 (rank : 60)
Query Neighborhood Hits	131	Target Neighborhood Hits	614	Shared Neighborhood Hits	75
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

MYST4_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.011331 (rank : 208)
Query Neighborhood Hits	131	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

STAB1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.076010 (rank : 86)
Query Neighborhood Hits	131	Target Neighborhood Hits	546	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

ZCHC7_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.020503 (rank : 194)
Query Neighborhood Hits	131	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

ZN669_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.006496 (rank : 226)
Query Neighborhood Hits	131	Target Neighborhood Hits	746	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BR6, Q5VT39, Q9H9Q6	Gene names	ZNF669
Domain Architecture	No domain graphic available
Description	Zinc finger protein 669.

ZN700_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.007282 (rank : 223)
Query Neighborhood Hits	131	Target Neighborhood Hits	772	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

AGRIN_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.055500 (rank : 131)
Query Neighborhood Hits	131	Target Neighborhood Hits	582	Shared Neighborhood Hits	49
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

CREL1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.071503 (rank : 92)
Query Neighborhood Hits	131	Target Neighborhood Hits	441	Shared Neighborhood Hits	56
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CREL1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.065962 (rank : 104)
Query Neighborhood Hits	131	Target Neighborhood Hits	524	Shared Neighborhood Hits	59
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

CRIM1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.051952 (rank : 163)
Query Neighborhood Hits	131	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

DLK_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.053110 (rank : 156)
Query Neighborhood Hits	131	Target Neighborhood Hits	401	Shared Neighborhood Hits	45
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

DLK_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.051813 (rank : 164)
Query Neighborhood Hits	131	Target Neighborhood Hits	374	Shared Neighborhood Hits	44
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DLL3_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.053725 (rank : 147)
Query Neighborhood Hits	131	Target Neighborhood Hits	419	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

DLL3_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.053101 (rank : 158)
Query Neighborhood Hits	131	Target Neighborhood Hits	399	Shared Neighborhood Hits	44
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

DNER_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.051540 (rank : 165)
Query Neighborhood Hits	131	Target Neighborhood Hits	460	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DNER_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.053340 (rank : 152)
Query Neighborhood Hits	131	Target Neighborhood Hits	413	Shared Neighborhood Hits	44
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

EDAR_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.136768 (rank : 49)
Query Neighborhood Hits	131	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

EDAR_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.138701 (rank : 47)
Query Neighborhood Hits	131	Target Neighborhood Hits	66	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R187, Q9DC43	Gene names	Edar, Dl
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless).

EGFL9_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.054474 (rank : 137)
Query Neighborhood Hits	131	Target Neighborhood Hits	365	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

EGFL9_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.055000 (rank : 135)
Query Neighborhood Hits	131	Target Neighborhood Hits	379	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

FBLN1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.056556 (rank : 124)
Query Neighborhood Hits	131	Target Neighborhood Hits	329	Shared Neighborhood Hits	49
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

FBLN2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.055771 (rank : 130)
Query Neighborhood Hits	131	Target Neighborhood Hits	392	Shared Neighborhood Hits	49
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

FBLN2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.053309 (rank : 153)
Query Neighborhood Hits	131	Target Neighborhood Hits	505	Shared Neighborhood Hits	50
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FBN1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.057717 (rank : 119)
Query Neighborhood Hits	131	Target Neighborhood Hits	557	Shared Neighborhood Hits	62
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.056568 (rank : 123)
Query Neighborhood Hits	131	Target Neighborhood Hits	563	Shared Neighborhood Hits	60
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.053484 (rank : 150)
Query Neighborhood Hits	131	Target Neighborhood Hits	560	Shared Neighborhood Hits	58
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.054094 (rank : 143)
Query Neighborhood Hits	131	Target Neighborhood Hits	549	Shared Neighborhood Hits	60
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.056433 (rank : 126)
Query Neighborhood Hits	131	Target Neighborhood Hits	543	Shared Neighborhood Hits	61
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FURIN_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.055376 (rank : 133)
Query Neighborhood Hits	131	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

FURIN_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.054475 (rank : 136)
Query Neighborhood Hits	131	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

JAG1_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.056275 (rank : 127)
Query Neighborhood Hits	131	Target Neighborhood Hits	514	Shared Neighborhood Hits	49
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.055122 (rank : 134)
Query Neighborhood Hits	131	Target Neighborhood Hits	518	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.054369 (rank : 139)
Query Neighborhood Hits	131	Target Neighborhood Hits	491	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.053666 (rank : 148)
Query Neighborhood Hits	131	Target Neighborhood Hits	504	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KR104_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.054469 (rank : 138)
Query Neighborhood Hits	131	Target Neighborhood Hits	313	Shared Neighborhood Hits	39
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR107_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.053159 (rank : 155)
Query Neighborhood Hits	131	Target Neighborhood Hits	330	Shared Neighborhood Hits	41
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KRA51_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.067008 (rank : 100)
Query Neighborhood Hits	131	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.066586 (rank : 103)
Query Neighborhood Hits	131	Target Neighborhood Hits	236	Shared Neighborhood Hits	33
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA53_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.065867 (rank : 105)
Query Neighborhood Hits	131	Target Neighborhood Hits	331	Shared Neighborhood Hits	46
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA54_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.070347 (rank : 95)
Query Neighborhood Hits	131	Target Neighborhood Hits	270	Shared Neighborhood Hits	37
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.053574 (rank : 149)
Query Neighborhood Hits	131	Target Neighborhood Hits	257	Shared Neighborhood Hits	36
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA57_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.052448 (rank : 162)
Query Neighborhood Hits	131	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.062177 (rank : 111)
Query Neighborhood Hits	131	Target Neighborhood Hits	324	Shared Neighborhood Hits	42
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.084527 (rank : 75)
Query Neighborhood Hits	131	Target Neighborhood Hits	310	Shared Neighborhood Hits	43
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

LAMA1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.091940 (rank : 66)
Query Neighborhood Hits	131	Target Neighborhood Hits	804	Shared Neighborhood Hits	67
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA2_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.080754 (rank : 80)
Query Neighborhood Hits	131	Target Neighborhood Hits	1092	Shared Neighborhood Hits	70
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA3_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.075039 (rank : 89)
Query Neighborhood Hits	131	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

LAMA3_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.080650 (rank : 81)
Query Neighborhood Hits	131	Target Neighborhood Hits	859	Shared Neighborhood Hits	67
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

LAMA4_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.058127 (rank : 118)
Query Neighborhood Hits	131	Target Neighborhood Hits	708	Shared Neighborhood Hits	42
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMA4_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.062521 (rank : 110)
Query Neighborhood Hits	131	Target Neighborhood Hits	584	Shared Neighborhood Hits	48
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMB1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.076176 (rank : 85)
Query Neighborhood Hits	131	Target Neighborhood Hits	1018	Shared Neighborhood Hits	55
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB1_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.081979 (rank : 79)
Query Neighborhood Hits	131	Target Neighborhood Hits	919	Shared Neighborhood Hits	63
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB3_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.063674 (rank : 109)
Query Neighborhood Hits	131	Target Neighborhood Hits	461	Shared Neighborhood Hits	41
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

LAMB3_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.061472 (rank : 113)
Query Neighborhood Hits	131	Target Neighborhood Hits	444	Shared Neighborhood Hits	43
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

LAMC2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.089172 (rank : 68)
Query Neighborhood Hits	131	Target Neighborhood Hits	715	Shared Neighborhood Hits	66
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

LTB1L_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.051166 (rank : 169)
Query Neighborhood Hits	131	Target Neighborhood Hits	553	Shared Neighborhood Hits	53
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1L_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.054238 (rank : 141)
Query Neighborhood Hits	131	Target Neighborhood Hits	514	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.050824 (rank : 171)
Query Neighborhood Hits	131	Target Neighborhood Hits	502	Shared Neighborhood Hits	51
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.054111 (rank : 142)
Query Neighborhood Hits	131	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.053842 (rank : 145)
Query Neighborhood Hits	131	Target Neighborhood Hits	552	Shared Neighborhood Hits	56
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LTBP3_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.050733 (rank : 172)
Query Neighborhood Hits	131	Target Neighborhood Hits	502	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

LTBP4_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.052575 (rank : 160)
Query Neighborhood Hits	131	Target Neighborhood Hits	607	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MEGF6_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.082373 (rank : 78)
Query Neighborhood Hits	131	Target Neighborhood Hits	671	Shared Neighborhood Hits	74
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

MEGF8_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.075724 (rank : 87)
Query Neighborhood Hits	131	Target Neighborhood Hits	528	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MEGF8_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.069203 (rank : 97)
Query Neighborhood Hits	131	Target Neighborhood Hits	520	Shared Neighborhood Hits	61
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

MEGF9_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.100670 (rank : 61)
Query Neighborhood Hits	131	Target Neighborhood Hits	896	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MUC5B_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.050068 (rank : 176)
Query Neighborhood Hits	131	Target Neighborhood Hits	1020	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NELL1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.057119 (rank : 121)
Query Neighborhood Hits	131	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.051385 (rank : 166)
Query Neighborhood Hits	131	Target Neighborhood Hits	436	Shared Neighborhood Hits	50
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NET1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.050322 (rank : 174)
Query Neighborhood Hits	131	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	O09118, Q60832, Q9QY50	Gene names	Ntn1
Domain Architecture
Description	Netrin-1 precursor.

NET2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.053260 (rank : 154)
Query Neighborhood Hits	131	Target Neighborhood Hits	194	Shared Neighborhood Hits	32
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

NET2_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.053103 (rank : 157)
Query Neighborhood Hits	131	Target Neighborhood Hits	193	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R1A3, Q9QY49, Q9WVA6	Gene names	Ntn2l, Ntn3
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor (Netrin-3).

NET4_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.056601 (rank : 122)
Query Neighborhood Hits	131	Target Neighborhood Hits	191	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB63, Q658K9, Q7L3F1, Q7L9D6, Q7Z5B6, Q9BZP1, Q9NT44, Q9P133	Gene names	NTN4
Domain Architecture	No domain graphic available
Description	Netrin-4 precursor (Beta-netrin) (Hepar-derived netrin-like protein).

NET4_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.053400 (rank : 151)
Query Neighborhood Hits	131	Target Neighborhood Hits	180	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JI33	Gene names	Ntn4
Domain Architecture	No domain graphic available
Description	Netrin-4 precursor (Beta-netrin).

NOTC1_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.051160 (rank : 170)
Query Neighborhood Hits	131	Target Neighborhood Hits	906	Shared Neighborhood Hits	56
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.051167 (rank : 168)
Query Neighborhood Hits	131	Target Neighborhood Hits	916	Shared Neighborhood Hits	53
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.053738 (rank : 146)
Query Neighborhood Hits	131	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.053889 (rank : 144)
Query Neighborhood Hits	131	Target Neighborhood Hits	975	Shared Neighborhood Hits	56
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC4_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.050063 (rank : 177)
Query Neighborhood Hits	131	Target Neighborhood Hits	905	Shared Neighborhood Hits	56
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.051239 (rank : 167)
Query Neighborhood Hits	131	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NTNG1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.060890 (rank : 115)
Query Neighborhood Hits	131	Target Neighborhood Hits	247	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NTNG1_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.061223 (rank : 114)
Query Neighborhood Hits	131	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NTNG2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.055929 (rank : 128)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q96CW9, Q6UXY0, Q96JH0	Gene names	NTNG2, KIAA1857, LMNT2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

NTNG2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.055837 (rank : 129)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8	Gene names	Ntng2, Lmnt2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

PCSK4_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.050465 (rank : 173)
Query Neighborhood Hits	131	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

PGBM_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.052516 (rank : 161)
Query Neighborhood Hits	131	Target Neighborhood Hits	1113	Shared Neighborhood Hits	65
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PGBM_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.056473 (rank : 125)
Query Neighborhood Hits	131	Target Neighborhood Hits	1073	Shared Neighborhood Hits	70
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

RSPO4_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.055437 (rank : 132)
Query Neighborhood Hits	131	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

SCUB3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.087394 (rank : 72)
Query Neighborhood Hits	131	Target Neighborhood Hits	428	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SCUB3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.089143 (rank : 69)
Query Neighborhood Hits	131	Target Neighborhood Hits	442	Shared Neighborhood Hits	74
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SREC2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.083789 (rank : 77)
Query Neighborhood Hits	131	Target Neighborhood Hits	645	Shared Neighborhood Hits	58
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.084046 (rank : 76)
Query Neighborhood Hits	131	Target Neighborhood Hits	605	Shared Neighborhood Hits	66
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.087846 (rank : 71)
Query Neighborhood Hits	131	Target Neighborhood Hits	645	Shared Neighborhood Hits	68
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

STAB1_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.066647 (rank : 102)
Query Neighborhood Hits	131	Target Neighborhood Hits	566	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

STAB2_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.060853 (rank : 116)
Query Neighborhood Hits	131	Target Neighborhood Hits	534	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

STAB2_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.066848 (rank : 101)
Query Neighborhood Hits	131	Target Neighborhood Hits	528	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TNR18_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.237780 (rank : 44)
Query Neighborhood Hits	131	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5U5, O95851, Q9NYJ9	Gene names	TNFRSF18, AITR, GITR
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 18 precursor (Glucocorticoid-induced TNFR-related protein) (Activation-inducible TNFR family receptor).

TNR18_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.165519 (rank : 46)
Query Neighborhood Hits	131	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	O35714, Q9JKR1, Q9JKR2, Q9JKR3	Gene names	Tnfrsf18, Gitr
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 18 precursor (Glucocorticoid-induced TNFR-related protein).

TNR9_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.440152 (rank : 35)
Query Neighborhood Hits	131	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

TRBM_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.052973 (rank : 159)
Query Neighborhood Hits	131	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

UROM_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.050294 (rank : 175)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	40
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

VWF_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.059649 (rank : 117)
Query Neighborhood Hits	131	Target Neighborhood Hits	396	Shared Neighborhood Hits	49
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.057572 (rank : 120)
Query Neighborhood Hits	131	Target Neighborhood Hits	381	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

Hits sorted by NC score

TNR1A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	131	Target Neighborhood Hits	131	Shared Neighborhood Hits	131
SwissProt Accessions	P25118	Gene names	Tnfrsf1a, Tnfr-1, Tnfr1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55).

TNR1A_HUMAN
NC score	0.944092 (rank : 2)	θ value	6.40027e-139 (rank : 2)
Query Neighborhood Hits	131	Target Neighborhood Hits	121	Shared Neighborhood Hits	67
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

TNR26_MOUSE
NC score	0.762696 (rank : 3)	θ value	3.76295e-14 (rank : 7)
Query Neighborhood Hits	131	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	P83626	Gene names	Tnfrsf26, Tnfrh3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 26 precursor (TNF receptor homolog 3).

TNR22_MOUSE
NC score	0.761237 (rank : 4)	θ value	5.25075e-16 (rank : 4)
Query Neighborhood Hits	131	Target Neighborhood Hits	97	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ER62, Q8VHB9, Q9CZA4	Gene names	Tnfrsf22, Dctrailr2, Tnfrh2, Tnfrsf1al2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 22 (Tumor necrosis factor receptor p60 homolog 2) (TNF receptor family member SOBa) (Decoy TRAIL receptor 2) (TNF receptor homolog 2).

TNR23_MOUSE
NC score	0.753967 (rank : 5)	θ value	6.85773e-16 (rank : 5)
Query Neighborhood Hits	131	Target Neighborhood Hits	114	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ER63, Q8VHC0	Gene names	Tnfrsf23, Dctrailr1, Tnfrh1, Tnfrsf1al1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 23 precursor (Tumor necrosis factor receptor p60 homolog 1) (TNF receptor family member SOB) (Decoy TRAIL receptor 1) (TNF receptor homolog 1).

TNR25_HUMAN
NC score	0.749053 (rank : 6)	θ value	8.93572e-24 (rank : 3)
Query Neighborhood Hits	131	Target Neighborhood Hits	172	Shared Neighborhood Hits	62
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

TNR3_HUMAN
NC score	0.707092 (rank : 7)	θ value	4.44505e-15 (rank : 6)
Query Neighborhood Hits	131	Target Neighborhood Hits	145	Shared Neighborhood Hits	64
SwissProt Accessions	P36941	Gene names	LTBR, TNFCR, TNFRSF3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor C receptor).

TNR14_HUMAN
NC score	0.697925 (rank : 8)	θ value	3.29651e-10 (rank : 15)
Query Neighborhood Hits	131	Target Neighborhood Hits	149	Shared Neighborhood Hits	64
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

TNR6_MOUSE
NC score	0.689120 (rank : 9)	θ value	1.58096e-12 (rank : 11)
Query Neighborhood Hits	131	Target Neighborhood Hits	99	Shared Neighborhood Hits	49
SwissProt Accessions	P25446, Q9DCQ1	Gene names	Fas, Apt1, Tnfrsf6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

TNR3_MOUSE
NC score	0.675719 (rank : 10)	θ value	9.26847e-13 (rank : 10)
Query Neighborhood Hits	131	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	P50284	Gene names	Ltbr, Tnfcr, Tnfrsf3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor).

TNR1B_HUMAN
NC score	0.667973 (rank : 11)	θ value	1.9326e-10 (rank : 12)
Query Neighborhood Hits	131	Target Neighborhood Hits	127	Shared Neighborhood Hits	58
SwissProt Accessions	P20333, Q16042, Q6YI29, Q9UIH1	Gene names	TNFRSF1B, TNFBR, TNFR2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor) (CD120b antigen) (Etanercept) [Contains: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBPII) (TBP- 2)].

TNR5_MOUSE
NC score	0.667543 (rank : 12)	θ value	5.43371e-13 (rank : 8)
Query Neighborhood Hits	131	Target Neighborhood Hits	131	Shared Neighborhood Hits	56
SwissProt Accessions	P27512, Q99NE0, Q99NE1, Q99NE2, Q99NE3	Gene names	Cd40, Tnfrsf5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50) (CDw40).

TNR1B_MOUSE
NC score	0.656080 (rank : 13)	θ value	2.52405e-10 (rank : 14)
Query Neighborhood Hits	131	Target Neighborhood Hits	123	Shared Neighborhood Hits	52
SwissProt Accessions	P25119, O88734, P97893	Gene names	Tnfrsf1b, Tnfr-2, Tnfr2
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1B precursor (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (p75) (p80 TNF-alpha receptor).

TR11B_HUMAN
NC score	0.653094 (rank : 14)	θ value	1.9326e-10 (rank : 13)
Query Neighborhood Hits	131	Target Neighborhood Hits	92	Shared Neighborhood Hits	57
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

TR11B_MOUSE
NC score	0.647886 (rank : 15)	θ value	1.06045e-08 (rank : 16)
Query Neighborhood Hits	131	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	O08712, O70202	Gene names	Tnfrsf11b, Ocif, Opg
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

TNR5_HUMAN
NC score	0.646147 (rank : 16)	θ value	8.97725e-08 (rank : 17)
Query Neighborhood Hits	131	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	P25942, Q9BYU0	Gene names	CD40, TNFRSF5
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (CDw40) (Bp50).

TNR16_MOUSE
NC score	0.642687 (rank : 17)	θ value	9.26847e-13 (rank : 9)
Query Neighborhood Hits	131	Target Neighborhood Hits	178	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

TNR4_MOUSE
NC score	0.631182 (rank : 18)	θ value	1.17247e-07 (rank : 18)
Query Neighborhood Hits	131	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	P47741	Gene names	Tnfrsf4, Ox40, Txgp1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (OX40 antigen).

TNR6_HUMAN
NC score	0.618694 (rank : 19)	θ value	8.40245e-06 (rank : 27)
Query Neighborhood Hits	131	Target Neighborhood Hits	95	Shared Neighborhood Hits	52
SwissProt Accessions	P25445, Q14292, Q14293, Q14294, Q14295, Q16652, Q6SSE9	Gene names	FAS, APT1, FAS1, TNFRSF6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6 precursor (FASLG receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95 antigen).

TNR6B_HUMAN
NC score	0.612312 (rank : 20)	θ value	0.00665767 (rank : 42)
Query Neighborhood Hits	131	Target Neighborhood Hits	103	Shared Neighborhood Hits	56
SwissProt Accessions	O95407	Gene names	TNFRSF6B, DCR3, TR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 6B precursor (Decoy receptor for Fas ligand) (Decoy receptor 3) (DcR3) (M68).

TNR16_HUMAN
NC score	0.600368 (rank : 21)	θ value	0.00020696 (rank : 33)
Query Neighborhood Hits	131	Target Neighborhood Hits	183	Shared Neighborhood Hits	71
SwissProt Accessions	P08138	Gene names	NGFR, TNFRSF16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Gp80-LNGFR) (p75 ICD) (Low affinity neurotrophin receptor p75NTR) (CD271 antigen).

TNR11_MOUSE
NC score	0.600193 (rank : 22)	θ value	1.53129e-07 (rank : 19)
Query Neighborhood Hits	131	Target Neighborhood Hits	121	Shared Neighborhood Hits	61
SwissProt Accessions	O35305, Q8VCT7	Gene names	Tnfrsf11a, Rank
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR).

TNR7_HUMAN
NC score	0.597659 (rank : 23)	θ value	3.77169e-06 (rank : 24)
Query Neighborhood Hits	131	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	P26842	Gene names	TNFRSF7, CD27
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27) (T14).

TNR4_HUMAN
NC score	0.596159 (rank : 24)	θ value	9.92553e-07 (rank : 21)
Query Neighborhood Hits	131	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

TNR11_HUMAN
NC score	0.582414 (rank : 25)	θ value	8.40245e-06 (rank : 25)
Query Neighborhood Hits	131	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y6Q6	Gene names	TNFRSF11A, RANK
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen).

TNR7_MOUSE
NC score	0.580692 (rank : 26)	θ value	1.69304e-06 (rank : 23)
Query Neighborhood Hits	131	Target Neighborhood Hits	112	Shared Neighborhood Hits	51
SwissProt Accessions	P41272	Gene names	Tnfrsf7, Cd27
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 7 precursor (CD27L receptor) (T-cell activation antigen CD27).

TNR21_HUMAN
NC score	0.544995 (rank : 27)	θ value	1.69304e-06 (rank : 22)
Query Neighborhood Hits	131	Target Neighborhood Hits	90	Shared Neighborhood Hits	48
SwissProt Accessions	O75509, Q96D86	Gene names	TNFRSF21, DR6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

TNR21_MOUSE
NC score	0.542818 (rank : 28)	θ value	9.92553e-07 (rank : 20)
Query Neighborhood Hits	131	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9EPU5, Q91W77, Q91XH9	Gene names	Tnfrsf21, Dr6
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 21 precursor (TNFR- related death receptor 6) (Death receptor 6).

TR10C_HUMAN
NC score	0.536884 (rank : 29)	θ value	7.1131e-05 (rank : 29)
Query Neighborhood Hits	131	Target Neighborhood Hits	105	Shared Neighborhood Hits	41
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

TNR8_HUMAN
NC score	0.529262 (rank : 30)	θ value	8.40245e-06 (rank : 28)
Query Neighborhood Hits	131	Target Neighborhood Hits	198	Shared Neighborhood Hits	65
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

TR10B_HUMAN
NC score	0.500812 (rank : 31)	θ value	0.000121331 (rank : 32)
Query Neighborhood Hits	131	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	O14763, O14720, O15508, O15517, O15531, Q9BVE0	Gene names	TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD262 antigen).

TR10D_HUMAN
NC score	0.481651 (rank : 32)	θ value	0.00035302 (rank : 35)
Query Neighborhood Hits	131	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBN6, Q9Y6Q4	Gene names	TNFRSF10D, DCR2, TRAILR4, TRUNDD
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10D precursor (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD264 antigen).

TR10B_MOUSE
NC score	0.476874 (rank : 33)	θ value	0.00228821 (rank : 40)
Query Neighborhood Hits	131	Target Neighborhood Hits	76	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZM4, Q9JJL5, Q9JJL6	Gene names	Tnfrsf10b, Dr5, Killer
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (MK).

TR10A_HUMAN
NC score	0.467072 (rank : 34)	θ value	0.00020696 (rank : 34)
Query Neighborhood Hits	131	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	O00220, Q96E62	Gene names	TNFRSF10A, APO2, DR4, TRAILR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10A precursor (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD261 antigen).

TNR9_MOUSE
NC score	0.440152 (rank : 35)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	131	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	P20334	Gene names	Tnfrsf9, Cd137, Cd157, Ila, Ly63
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB) (CD137 antigen).

TNR9_HUMAN
NC score	0.432307 (rank : 36)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	131	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q07011	Gene names	TNFRSF9, CD137, ILA
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 9 precursor (4-1BB ligand receptor) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD137 antigen).

TNR27_HUMAN
NC score	0.422716 (rank : 37)	θ value	8.40245e-06 (rank : 26)
Query Neighborhood Hits	131	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HAV5, Q6UWM2, Q8IZA6	Gene names	EDA2R, TNFRSF27, XEDAR
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

TNR8_MOUSE
NC score	0.401642 (rank : 38)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	131	Target Neighborhood Hits	208	Shared Neighborhood Hits	52
SwissProt Accessions	Q60846	Gene names	Tnfrsf8
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30).

TNR27_MOUSE
NC score	0.380972 (rank : 39)	θ value	0.000461057 (rank : 36)
Query Neighborhood Hits	131	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX35, Q8BM50	Gene names	Eda2r, Tnfrsf27, Xedar
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor).

TNR19_MOUSE
NC score	0.380170 (rank : 40)	θ value	0.000121331 (rank : 31)
Query Neighborhood Hits	131	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLL3, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9QXW7	Gene names	Tnfrsf19, Taj, Troy
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

TNR19_HUMAN
NC score	0.335793 (rank : 41)	θ value	9.29e-05 (rank : 30)
Query Neighborhood Hits	131	Target Neighborhood Hits	89	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS68, Q9BXZ9, Q9BY00, Q9NZV2	Gene names	TNFRSF19, TAJ, TROY
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19 precursor (Toxicity and JNK inducer) (TRADE).

TR19L_MOUSE
NC score	0.300932 (rank : 42)	θ value	0.00390308 (rank : 41)
Query Neighborhood Hits	131	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX43, Q8BTV0	Gene names	Tnfrsf19l
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 19L precursor.

TR19L_HUMAN
NC score	0.261773 (rank : 43)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	131	Target Neighborhood Hits	99	Shared Neighborhood Hits	36
SwissProt Accessions	Q969Z4, Q86V34, Q96JU1, Q9BUX7	Gene names	TNFRSF19L, RELT
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 19L precursor (Receptor expressed in lymphoid tissues).

TNR18_HUMAN
NC score	0.237780 (rank : 44)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	131	Target Neighborhood Hits	55	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5U5, O95851, Q9NYJ9	Gene names	TNFRSF18, AITR, GITR
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 18 precursor (Glucocorticoid-induced TNFR-related protein) (Activation-inducible TNFR family receptor).

PCSK5_MOUSE
NC score	0.174865 (rank : 45)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	131	Target Neighborhood Hits	613	Shared Neighborhood Hits	93
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

TNR18_MOUSE
NC score	0.165519 (rank : 46)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	131	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	O35714, Q9JKR1, Q9JKR2, Q9JKR3	Gene names	Tnfrsf18, Gitr
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 18 precursor (Glucocorticoid-induced TNFR-related protein).

EDAR_MOUSE
NC score	0.138701 (rank : 47)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	131	Target Neighborhood Hits	66	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R187, Q9DC43	Gene names	Edar, Dl
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless).

PCSK5_HUMAN
NC score	0.137547 (rank : 48)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	131	Target Neighborhood Hits	291	Shared Neighborhood Hits	66
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

EDAR_HUMAN
NC score	0.136768 (rank : 49)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	131	Target Neighborhood Hits	84	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

PCSK6_HUMAN
NC score	0.123868 (rank : 50)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	131	Target Neighborhood Hits	298	Shared Neighborhood Hits	58
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

LAMC3_HUMAN
NC score	0.112926 (rank : 51)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	131	Target Neighborhood Hits	588	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

FRAS1_HUMAN
NC score	0.112424 (rank : 52)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	131	Target Neighborhood Hits	759	Shared Neighborhood Hits	86
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

LAMC3_MOUSE
NC score	0.111959 (rank : 53)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	131	Target Neighborhood Hits	624	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

ZAN_MOUSE
NC score	0.111846 (rank : 54)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	131	Target Neighborhood Hits	808	Shared Neighborhood Hits	72
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

FADD_MOUSE
NC score	0.110716 (rank : 55)	θ value	0.0252991 (rank : 44)
Query Neighborhood Hits	131	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

LAMA5_HUMAN
NC score	0.107850 (rank : 56)	θ value	1.38821 (rank : 83)
Query Neighborhood Hits	131	Target Neighborhood Hits	976	Shared Neighborhood Hits	82
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

MEGF9_HUMAN
NC score	0.107769 (rank : 57)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	131	Target Neighborhood Hits	557	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

FRAS1_MOUSE
NC score	0.103477 (rank : 58)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	131	Target Neighborhood Hits	747	Shared Neighborhood Hits	84
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

LAMA5_MOUSE
NC score	0.102833 (rank : 59)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	131	Target Neighborhood Hits	828	Shared Neighborhood Hits	77
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMC2_MOUSE
NC score	0.102115 (rank : 60)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	131	Target Neighborhood Hits	614	Shared Neighborhood Hits	75
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

MEGF9_MOUSE
NC score	0.100670 (rank : 61)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	131	Target Neighborhood Hits	896	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

LAMB2_MOUSE
NC score	0.096387 (rank : 62)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	131	Target Neighborhood Hits	722	Shared Neighborhood Hits	66
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

LAMC1_HUMAN
NC score	0.096144 (rank : 63)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	131	Target Neighborhood Hits	922	Shared Neighborhood Hits	66
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMA1_MOUSE
NC score	0.095940 (rank : 64)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	131	Target Neighborhood Hits	838	Shared Neighborhood Hits	78
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

USH2A_MOUSE
NC score	0.093691 (rank : 65)	θ value	0.0252991 (rank : 45)
Query Neighborhood Hits	131	Target Neighborhood Hits	626	Shared Neighborhood Hits	65
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

LAMA1_HUMAN
NC score	0.091940 (rank : 66)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	131	Target Neighborhood Hits	804	Shared Neighborhood Hits	67
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMC1_MOUSE
NC score	0.090490 (rank : 67)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	131	Target Neighborhood Hits	856	Shared Neighborhood Hits	66
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LAMC2_HUMAN
NC score	0.089172 (rank : 68)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	131	Target Neighborhood Hits	715	Shared Neighborhood Hits	66
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

SCUB3_MOUSE
NC score	0.089143 (rank : 69)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	131	Target Neighborhood Hits	442	Shared Neighborhood Hits	74
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

USH2A_HUMAN
NC score	0.088152 (rank : 70)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	131	Target Neighborhood Hits	600	Shared Neighborhood Hits	66
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

SREC_HUMAN
NC score	0.087846 (rank : 71)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	131	Target Neighborhood Hits	645	Shared Neighborhood Hits	68
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SCUB3_HUMAN
NC score	0.087394 (rank : 72)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	131	Target Neighborhood Hits	428	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

FADD_HUMAN
NC score	0.086142 (rank : 73)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	131	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q13158, Q14866	Gene names	FADD, MORT1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

LAMB2_HUMAN
NC score	0.084928 (rank : 74)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	131	Target Neighborhood Hits	692	Shared Neighborhood Hits	63
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

KRA59_HUMAN
NC score	0.084527 (rank : 75)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	131	Target Neighborhood Hits	310	Shared Neighborhood Hits	43
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

SREC2_MOUSE
NC score	0.084046 (rank : 76)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	131	Target Neighborhood Hits	605	Shared Neighborhood Hits	66
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC2_HUMAN
NC score	0.083789 (rank : 77)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	131	Target Neighborhood Hits	645	Shared Neighborhood Hits	58
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MEGF6_HUMAN
NC score	0.082373 (rank : 78)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	131	Target Neighborhood Hits	671	Shared Neighborhood Hits	74
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

LAMB1_MOUSE
NC score	0.081979 (rank : 79)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	131	Target Neighborhood Hits	919	Shared Neighborhood Hits	63
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMA2_HUMAN
NC score	0.080754 (rank : 80)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	131	Target Neighborhood Hits	1092	Shared Neighborhood Hits	70
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA3_MOUSE
NC score	0.080650 (rank : 81)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	131	Target Neighborhood Hits	859	Shared Neighborhood Hits	67
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

DLL4_MOUSE
NC score	0.078994 (rank : 82)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	131	Target Neighborhood Hits	440	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DLL4_HUMAN
NC score	0.077395 (rank : 83)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	131	Target Neighborhood Hits	435	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

LAMA2_MOUSE
NC score	0.077340 (rank : 84)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	131	Target Neighborhood Hits	1198	Shared Neighborhood Hits	67
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMB1_HUMAN
NC score	0.076176 (rank : 85)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	131	Target Neighborhood Hits	1018	Shared Neighborhood Hits	55
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

STAB1_HUMAN
NC score	0.076010 (rank : 86)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	131	Target Neighborhood Hits	546	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

MEGF8_HUMAN
NC score	0.075724 (rank : 87)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	131	Target Neighborhood Hits	528	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z7M0, O75097	Gene names	MEGF8, EGFL4, KIAA0817
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

ZAN_HUMAN
NC score	0.075415 (rank : 88)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	131	Target Neighborhood Hits	679	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

LAMA3_HUMAN
NC score	0.075039 (rank : 89)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	131	Target Neighborhood Hits	760	Shared Neighborhood Hits	58
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

DLL1_MOUSE
NC score	0.072984 (rank : 90)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	131	Target Neighborhood Hits	456	Shared Neighborhood Hits	51
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

TECTA_MOUSE
NC score	0.072346 (rank : 91)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	131	Target Neighborhood Hits	244	Shared Neighborhood Hits	31
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

CREL1_HUMAN
NC score	0.071503 (rank : 92)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	131	Target Neighborhood Hits	441	Shared Neighborhood Hits	56
SwissProt Accessions	Q96HD1, Q6I9X5, Q8NFT4, Q9Y409	Gene names	CRELD1, CIRRIN
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

SSPO_MOUSE
NC score	0.071493 (rank : 93)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	131	Target Neighborhood Hits	800	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

DLL1_HUMAN
NC score	0.071470 (rank : 94)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	131	Target Neighborhood Hits	455	Shared Neighborhood Hits	49
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

KRA54_HUMAN
NC score	0.070347 (rank : 95)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	131	Target Neighborhood Hits	270	Shared Neighborhood Hits	37
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

TECTA_HUMAN
NC score	0.069628 (rank : 96)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	131	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

MEGF8_MOUSE
NC score	0.069203 (rank : 97)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	131	Target Neighborhood Hits	520	Shared Neighborhood Hits	61
SwissProt Accessions	P60882, Q80TR3, Q80V41, Q8BMN9, Q8JZW7, Q8K0J3	Gene names	Megf8, Egfl4
Domain Architecture
Description	Multiple epidermal growth factor-like domains 8 (EGF-like domain- containing protein 4) (Multiple EGF-like domain protein 4).

RSPO1_HUMAN
NC score	0.067604 (rank : 98)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	131	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

FBLN5_HUMAN
NC score	0.067333 (rank : 99)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	131	Target Neighborhood Hits	329	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBX5, O75966, Q6UWA3	Gene names	FBLN5, DANCE
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50).

KRA51_HUMAN
NC score	0.067008 (rank : 100)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	131	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

STAB2_MOUSE
NC score	0.066848 (rank : 101)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	131	Target Neighborhood Hits	528	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

STAB1_MOUSE
NC score	0.066647 (rank : 102)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	131	Target Neighborhood Hits	566	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

KRA52_HUMAN
NC score	0.066586 (rank : 103)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	131	Target Neighborhood Hits	236	Shared Neighborhood Hits	33
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

CREL1_MOUSE
NC score	0.065962 (rank : 104)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	131	Target Neighborhood Hits	524	Shared Neighborhood Hits	59
SwissProt Accessions	Q91XD7, Q8BGJ8	Gene names	Creld1
Domain Architecture	No domain graphic available
Description	Cysteine-rich with EGF-like domain protein 1 precursor.

KRA53_HUMAN
NC score	0.065867 (rank : 105)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	131	Target Neighborhood Hits	331	Shared Neighborhood Hits	46
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

MATN2_HUMAN
NC score	0.065837 (rank : 106)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	131	Target Neighborhood Hits	365	Shared Neighborhood Hits	48
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

FBLN5_MOUSE
NC score	0.063898 (rank : 107)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	131	Target Neighborhood Hits	317	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVH9, Q541Z7	Gene names	Fbln5, Dance
Domain Architecture
Description	Fibulin-5 precursor (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance).

MATN2_MOUSE
NC score	0.063855 (rank : 108)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	131	Target Neighborhood Hits	356	Shared Neighborhood Hits	48
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

LAMB3_HUMAN
NC score	0.063674 (rank : 109)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	131	Target Neighborhood Hits	461	Shared Neighborhood Hits	41
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

LAMA4_MOUSE
NC score	0.062521 (rank : 110)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	131	Target Neighborhood Hits	584	Shared Neighborhood Hits	48
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

KRA58_HUMAN
NC score	0.062177 (rank : 111)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	131	Target Neighborhood Hits	324	Shared Neighborhood Hits	42
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

LTBP2_MOUSE
NC score	0.061613 (rank : 112)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	131	Target Neighborhood Hits	617	Shared Neighborhood Hits	57
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LAMB3_MOUSE
NC score	0.061472 (rank : 113)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	131	Target Neighborhood Hits	444	Shared Neighborhood Hits	43
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

NTNG1_MOUSE
NC score	0.061223 (rank : 114)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	131	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4G0, Q68FE5, Q69ZU3, Q8R4F3, Q8R4F4, Q8R4F5, Q8R4F6, Q8R4F7, Q8R4F8, Q8R4F9, Q9ESR3, Q9ESR4, Q9ESR5, Q9ESR6, Q9ESR7, Q9ESR8	Gene names	Ntng1, Kiaa0976, Lmnt1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

NTNG1_HUMAN
NC score	0.060890 (rank : 115)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	131	Target Neighborhood Hits	247	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2I2, Q5VU86, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633	Gene names	NTNG1, KIAA0976, LMNT1
Domain Architecture
Description	Netrin G1 precursor (Laminet-1).

STAB2_HUMAN
NC score	0.060853 (rank : 116)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	131	Target Neighborhood Hits	534	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

VWF_HUMAN
NC score	0.059649 (rank : 117)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	131	Target Neighborhood Hits	396	Shared Neighborhood Hits	49
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

LAMA4_HUMAN
NC score	0.058127 (rank : 118)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	131	Target Neighborhood Hits	708	Shared Neighborhood Hits	42
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

FBN1_HUMAN
NC score	0.057717 (rank : 119)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	131	Target Neighborhood Hits	557	Shared Neighborhood Hits	62
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

VWF_MOUSE
NC score	0.057572 (rank : 120)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	131	Target Neighborhood Hits	381	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

NELL1_HUMAN
NC score	0.057119 (rank : 121)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	131	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NET4_HUMAN
NC score	0.056601 (rank : 122)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	131	Target Neighborhood Hits	191	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB63, Q658K9, Q7L3F1, Q7L9D6, Q7Z5B6, Q9BZP1, Q9NT44, Q9P133	Gene names	NTN4
Domain Architecture	No domain graphic available
Description	Netrin-4 precursor (Beta-netrin) (Hepar-derived netrin-like protein).

FBN1_MOUSE
NC score	0.056568 (rank : 123)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	131	Target Neighborhood Hits	563	Shared Neighborhood Hits	60
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBLN1_MOUSE
NC score	0.056556 (rank : 124)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	131	Target Neighborhood Hits	329	Shared Neighborhood Hits	49
SwissProt Accessions	Q08879, Q08878, Q8C3B1, Q91ZC9, Q922K8	Gene names	Fbln1
Domain Architecture
Description	Fibulin-1 precursor (Basement-membrane protein 90) (BM-90).

PGBM_MOUSE
NC score	0.056473 (rank : 125)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	131	Target Neighborhood Hits	1073	Shared Neighborhood Hits	70
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

FBN3_HUMAN
NC score	0.056433 (rank : 126)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	131	Target Neighborhood Hits	543	Shared Neighborhood Hits	61
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

JAG1_HUMAN
NC score	0.056275 (rank : 127)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	131	Target Neighborhood Hits	514	Shared Neighborhood Hits	49
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

NTNG2_HUMAN
NC score	0.055929 (rank : 128)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q96CW9, Q6UXY0, Q96JH0	Gene names	NTNG2, KIAA1857, LMNT2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

NTNG2_MOUSE
NC score	0.055837 (rank : 129)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8	Gene names	Ntng2, Lmnt2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

FBLN2_HUMAN
NC score	0.055771 (rank : 130)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	131	Target Neighborhood Hits	392	Shared Neighborhood Hits	49
SwissProt Accessions	P98095	Gene names	FBLN2
Domain Architecture
Description	Fibulin-2 precursor.

AGRIN_HUMAN
NC score	0.055500 (rank : 131)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	131	Target Neighborhood Hits	582	Shared Neighborhood Hits	49
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

RSPO4_HUMAN
NC score	0.055437 (rank : 132)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	131	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

FURIN_HUMAN
NC score	0.055376 (rank : 133)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	131	Target Neighborhood Hits	52	Shared Neighborhood Hits	12
SwissProt Accessions	P09958, Q14336, Q6LBS3	Gene names	FURIN, FUR, PACE
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme).

JAG1_MOUSE
NC score	0.055122 (rank : 134)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	131	Target Neighborhood Hits	518	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

EGFL9_MOUSE
NC score	0.055000 (rank : 135)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	131	Target Neighborhood Hits	379	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

FURIN_MOUSE
NC score	0.054475 (rank : 136)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	131	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	P23188	Gene names	Furin, Fur, Pcsk3
Domain Architecture
Description	Furin precursor (EC 3.4.21.75) (Paired basic amino acid residue cleaving enzyme) (PACE) (Dibasic-processing enzyme) (Prohormone convertase 3).

EGFL9_HUMAN
NC score	0.054474 (rank : 137)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	131	Target Neighborhood Hits	365	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

KR104_HUMAN
NC score	0.054469 (rank : 138)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	131	Target Neighborhood Hits	313	Shared Neighborhood Hits	39
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

JAG2_HUMAN
NC score	0.054369 (rank : 139)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	131	Target Neighborhood Hits	491	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

KR106_HUMAN
NC score	0.054359 (rank : 140)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	131	Target Neighborhood Hits	347	Shared Neighborhood Hits	45
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

LTB1L_MOUSE
NC score	0.054238 (rank : 141)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	131	Target Neighborhood Hits	514	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_MOUSE
NC score	0.054111 (rank : 142)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	131	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	Q8CG18, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FBN2_MOUSE
NC score	0.054094 (rank : 143)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	131	Target Neighborhood Hits	549	Shared Neighborhood Hits	60
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

NOTC3_MOUSE
NC score	0.053889 (rank : 144)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	131	Target Neighborhood Hits	975	Shared Neighborhood Hits	56
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

LTBP2_HUMAN
NC score	0.053842 (rank : 145)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	131	Target Neighborhood Hits	552	Shared Neighborhood Hits	56
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

NOTC3_HUMAN
NC score	0.053738 (rank : 146)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	131	Target Neighborhood Hits	1062	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

DLL3_HUMAN
NC score	0.053725 (rank : 147)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	131	Target Neighborhood Hits	419	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

JAG2_MOUSE
NC score	0.053666 (rank : 148)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	131	Target Neighborhood Hits	504	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

KRA55_HUMAN
NC score	0.053574 (rank : 149)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	131	Target Neighborhood Hits	257	Shared Neighborhood Hits	36
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

FBN2_HUMAN
NC score	0.053484 (rank : 150)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	131	Target Neighborhood Hits	560	Shared Neighborhood Hits	58
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

NET4_MOUSE
NC score	0.053400 (rank : 151)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	131	Target Neighborhood Hits	180	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JI33	Gene names	Ntn4
Domain Architecture	No domain graphic available
Description	Netrin-4 precursor (Beta-netrin).

DNER_MOUSE
NC score	0.053340 (rank : 152)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	131	Target Neighborhood Hits	413	Shared Neighborhood Hits	44
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

FBLN2_MOUSE
NC score	0.053309 (rank : 153)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	131	Target Neighborhood Hits	505	Shared Neighborhood Hits	50
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

NET2_HUMAN
NC score	0.053260 (rank : 154)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	131	Target Neighborhood Hits	194	Shared Neighborhood Hits	32
SwissProt Accessions	O00634	Gene names	NTN2L
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor.

KR107_HUMAN
NC score	0.053159 (rank : 155)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	131	Target Neighborhood Hits	330	Shared Neighborhood Hits	41
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

DLK_HUMAN
NC score	0.053110 (rank : 156)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	131	Target Neighborhood Hits	401	Shared Neighborhood Hits	45
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

NET2_MOUSE
NC score	0.053103 (rank : 157)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	131	Target Neighborhood Hits	193	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R1A3, Q9QY49, Q9WVA6	Gene names	Ntn2l, Ntn3
Domain Architecture	No domain graphic available
Description	Netrin-2-like protein precursor (Netrin-3).

DLL3_MOUSE
NC score	0.053101 (rank : 158)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	131	Target Neighborhood Hits	399	Shared Neighborhood Hits	44
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

TRBM_MOUSE
NC score	0.052973 (rank : 159)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	131	Target Neighborhood Hits	361	Shared Neighborhood Hits	46
SwissProt Accessions	P15306	Gene names	Thbd
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

LTBP4_MOUSE
NC score	0.052575 (rank : 160)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	131	Target Neighborhood Hits	607	Shared Neighborhood Hits	53
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

PGBM_HUMAN
NC score	0.052516 (rank : 161)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	131	Target Neighborhood Hits	1113	Shared Neighborhood Hits	65
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KRA57_HUMAN
NC score	0.052448 (rank : 162)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	131	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

CRIM1_HUMAN
NC score	0.051952 (rank : 163)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	131	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

DLK_MOUSE
NC score	0.051813 (rank : 164)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	131	Target Neighborhood Hits	374	Shared Neighborhood Hits	44
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DNER_HUMAN
NC score	0.051540 (rank : 165)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	131	Target Neighborhood Hits	460	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

NELL2_MOUSE
NC score	0.051385 (rank : 166)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	131	Target Neighborhood Hits	436	Shared Neighborhood Hits	50
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NOTC4_MOUSE
NC score	0.051239 (rank : 167)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	131	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC1_MOUSE
NC score	0.051167 (rank : 168)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	131	Target Neighborhood Hits	916	Shared Neighborhood Hits	53
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

LTB1L_HUMAN
NC score	0.051166 (rank : 169)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	131	Target Neighborhood Hits	553	Shared Neighborhood Hits	53
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

NOTC1_HUMAN
NC score	0.051160 (rank : 170)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	131	Target Neighborhood Hits	906	Shared Neighborhood Hits	56
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

LTB1S_HUMAN
NC score	0.050824 (rank : 171)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	131	Target Neighborhood Hits	502	Shared Neighborhood Hits	51
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTBP3_HUMAN
NC score	0.050733 (rank : 172)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	131	Target Neighborhood Hits	502	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NS15, O15107, Q96HB9, Q9H7K2, Q9UFN4	Gene names	LTBP3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

PCSK4_HUMAN
NC score	0.050465 (rank : 173)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	131	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UW60, Q8IY88, Q9UF79	Gene names	PCSK4, PC4
Domain Architecture	No domain graphic available
Description	Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-) (Proprotein convertase PC4).

NET1_MOUSE
NC score	0.050322 (rank : 174)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	131	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	O09118, Q60832, Q9QY50	Gene names	Ntn1
Domain Architecture
Description	Netrin-1 precursor.

UROM_MOUSE
NC score	0.050294 (rank : 175)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	131	Target Neighborhood Hits	276	Shared Neighborhood Hits	40
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

MUC5B_HUMAN
NC score	0.050068 (rank : 176)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	131	Target Neighborhood Hits	1020	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NOTC4_HUMAN
NC score	0.050063 (rank : 177)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	131	Target Neighborhood Hits	905	Shared Neighborhood Hits	56
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

FHL2_MOUSE
NC score	0.049565 (rank : 178)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	131	Target Neighborhood Hits	539	Shared Neighborhood Hits	36
SwissProt Accessions	O70433, P97448	Gene names	Fhl2
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3).

FBLN3_HUMAN
NC score	0.048311 (rank : 179)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	131	Target Neighborhood Hits	293	Shared Neighborhood Hits	42
SwissProt Accessions	Q12805	Gene names	EFEMP1, FBLN3, FBNL
Domain Architecture
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3) (Fibrillin-like protein) (Extracellular protein S1-5).

FBLN3_MOUSE
NC score	0.048267 (rank : 180)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	131	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BPB5, Q6Y3N6	Gene names	Efemp1, Fbln3
Domain Architecture	No domain graphic available
Description	EGF-containing fibulin-like extracellular matrix protein 1 precursor (Fibulin-3) (FIBL-3).

C1QR1_HUMAN
NC score	0.045145 (rank : 181)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	131	Target Neighborhood Hits	493	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

LRP1B_MOUSE
NC score	0.042466 (rank : 182)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	131	Target Neighborhood Hits	606	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

FHL2_HUMAN
NC score	0.042206 (rank : 183)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	131	Target Neighborhood Hits	533	Shared Neighborhood Hits	30
SwissProt Accessions	Q14192, Q13229, Q13644, Q9P294	Gene names	FHL2, DRAL, SLIM3
Domain Architecture
Description	Four and a half LIM domains protein 2 (FHL-2) (Skeletal muscle LIM- protein 3) (SLIM 3) (LIM-domain protein DRAL).

EMR1_HUMAN
NC score	0.041132 (rank : 184)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	131	Target Neighborhood Hits	382	Shared Neighborhood Hits	42
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

MYCB2_HUMAN
NC score	0.037255 (rank : 185)	θ value	1.06291 (rank : 77)
Query Neighborhood Hits	131	Target Neighborhood Hits	390	Shared Neighborhood Hits	15
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYCB2_MOUSE
NC score	0.036766 (rank : 186)	θ value	1.06291 (rank : 78)
Query Neighborhood Hits	131	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

FBLI1_HUMAN
NC score	0.031352 (rank : 187)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	131	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

ITB2_HUMAN
NC score	0.031180 (rank : 188)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	131	Target Neighborhood Hits	282	Shared Neighborhood Hits	40
SwissProt Accessions	P05107, Q16418	Gene names	ITGB2, CD18
Domain Architecture
Description	Integrin beta-2 precursor (Cell surface adhesion glycoproteins LFA- 1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD18 antigen).

IBRD3_HUMAN
NC score	0.029578 (rank : 189)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	131	Target Neighborhood Hits	70	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

HGFA_MOUSE
NC score	0.028081 (rank : 190)	θ value	0.00228821 (rank : 39)
Query Neighborhood Hits	131	Target Neighborhood Hits	419	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R098, Q9JKV4	Gene names	Hgfac
Domain Architecture
Description	Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain].

FBLI1_MOUSE
NC score	0.027656 (rank : 191)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	131	Target Neighborhood Hits	228	Shared Neighborhood Hits	9
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

MFGM_MOUSE
NC score	0.026222 (rank : 192)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	131	Target Neighborhood Hits	233	Shared Neighborhood Hits	25
SwissProt Accessions	P21956, P97800, Q3TBN5, Q9R1X9, Q9WTS3	Gene names	Mfge8
Domain Architecture
Description	Lactadherin precursor (Milk fat globule-EGF factor 8) (MFG-E8) (MFGM) (Sperm surface protein SP47) (MP47).

TRI59_MOUSE
NC score	0.022930 (rank : 193)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	131	Target Neighborhood Hits	292	Shared Neighborhood Hits	5
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

ZCHC7_HUMAN
NC score	0.020503 (rank : 194)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	131	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

FA10_MOUSE
NC score	0.019207 (rank : 195)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	131	Target Neighborhood Hits	435	Shared Neighborhood Hits	33
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

TRAF2_MOUSE
NC score	0.018417 (rank : 196)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	131	Target Neighborhood Hits	394	Shared Neighborhood Hits	11
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

THYG_HUMAN
NC score	0.018341 (rank : 197)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	131	Target Neighborhood Hits	154	Shared Neighborhood Hits	23
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

ANK3_HUMAN
NC score	0.016944 (rank : 198)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	131	Target Neighborhood Hits	853	Shared Neighborhood Hits	16
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ABLM2_MOUSE
NC score	0.016747 (rank : 199)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	131	Target Neighborhood Hits	306	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BL65, Q6H8P8, Q80WK6, Q8BUT1, Q8BXI7	Gene names	Ablim2
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 2 (Actin-binding LIM protein family member 2) (abLIM-2).

DHX37_HUMAN
NC score	0.015697 (rank : 200)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	131	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

PPRB_HUMAN
NC score	0.015173 (rank : 201)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	131	Target Neighborhood Hits	311	Shared Neighborhood Hits	5
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

ANK2_HUMAN
NC score	0.013539 (rank : 202)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	131	Target Neighborhood Hits	1615	Shared Neighborhood Hits	18
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

PLXB3_MOUSE
NC score	0.013505 (rank : 203)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	131	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QY40, Q80TH8	Gene names	Plxnb3, Kiaa1206, Plxn6
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor (Plexin-6).

S23IP_MOUSE
NC score	0.013164 (rank : 204)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	131	Target Neighborhood Hits	363	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

MYST4_MOUSE
NC score	0.013027 (rank : 205)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	131	Target Neighborhood Hits	416	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

SCYL2_HUMAN
NC score	0.012133 (rank : 206)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	131	Target Neighborhood Hits	632	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

GRAM3_HUMAN
NC score	0.011845 (rank : 207)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	131	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q96HH9, Q9H753	Gene names	GRAMD3, NS3TP2
Domain Architecture	No domain graphic available
Description	GRAM domain-containing protein 3 (HCV NS3-transactivated protein 2).

MYST4_HUMAN
NC score	0.011331 (rank : 208)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	131	Target Neighborhood Hits	671	Shared Neighborhood Hits	13
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

RNF8_MOUSE
NC score	0.011134 (rank : 209)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	131	Target Neighborhood Hits	618	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

PLXB3_HUMAN
NC score	0.010671 (rank : 210)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	131	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULL4, Q9HDA4	Gene names	PLXNB3, KIAA1206
Domain Architecture	No domain graphic available
Description	Plexin-B3 precursor.

ZN155_HUMAN
NC score	0.010588 (rank : 211)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	131	Target Neighborhood Hits	786	Shared Neighborhood Hits	31
SwissProt Accessions	Q12901, Q9UIE1, Q9UK14	Gene names	ZNF155
Domain Architecture
Description	Zinc finger protein 155.

ZN224_HUMAN
NC score	0.010572 (rank : 212)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	131	Target Neighborhood Hits	808	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).

ZN221_HUMAN
NC score	0.009838 (rank : 213)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	131	Target Neighborhood Hits	784	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UK13, Q9P1U8	Gene names	ZNF221
Domain Architecture
Description	Zinc finger protein 221.

SCYL2_MOUSE
NC score	0.009714 (rank : 214)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	131	Target Neighborhood Hits	603	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ADA32_MOUSE
NC score	0.009342 (rank : 215)	θ value	1.81305 (rank : 86)
Query Neighborhood Hits	131	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

ERBB4_HUMAN
NC score	0.009254 (rank : 216)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	131	Target Neighborhood Hits	910	Shared Neighborhood Hits	18
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ZN473_HUMAN
NC score	0.009085 (rank : 217)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	131	Target Neighborhood Hits	765	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WTR7, Q9ULS9, Q9Y4Q7	Gene names	ZNF473, KIAA1141, ZFP100
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100).

ZN583_HUMAN
NC score	0.008359 (rank : 218)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	131	Target Neighborhood Hits	774	Shared Neighborhood Hits	15
SwissProt Accessions	Q96ND8, O14850, Q2NKK3	Gene names	ZNF583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583 (Zinc finger protein L3-5).

ZN583_MOUSE
NC score	0.007821 (rank : 219)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	131	Target Neighborhood Hits	774	Shared Neighborhood Hits	16
SwissProt Accessions	Q3V080, Q3V3L4	Gene names	Znf583, Zfp583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583.

ZN460_HUMAN
NC score	0.007757 (rank : 220)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	131	Target Neighborhood Hits	745	Shared Neighborhood Hits	17
SwissProt Accessions	Q14592, Q6VSF8	Gene names	ZNF460, ZNF272
Domain Architecture	No domain graphic available
Description	Zinc finger protein 460 (Zinc finger protein 272) (Zinc finger protein HZF8).

ZN519_HUMAN
NC score	0.007513 (rank : 221)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	131	Target Neighborhood Hits	738	Shared Neighborhood Hits	16
SwissProt Accessions	Q8TB69	Gene names	ZNF519
Domain Architecture
Description	Zinc finger protein 519.

ZN614_HUMAN
NC score	0.007331 (rank : 222)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	131	Target Neighborhood Hits	752	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N883, Q494T8, Q8TCF4	Gene names	ZNF614
Domain Architecture	No domain graphic available
Description	Zinc finger protein 614.

ZN700_HUMAN
NC score	0.007282 (rank : 223)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	131	Target Neighborhood Hits	772	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

TS1R1_HUMAN
NC score	0.007106 (rank : 224)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	131	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0	Gene names	TAS1R1, GPR70, T1R1, TR1
Domain Architecture	No domain graphic available
Description	Taste receptor type 1 member 1 precursor (G-protein coupled receptor 70) (Gm148).

ZNF16_HUMAN
NC score	0.007067 (rank : 225)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	131	Target Neighborhood Hits	771	Shared Neighborhood Hits	19
SwissProt Accessions	P17020, Q96FG0	Gene names	ZNF16, KOX9
Domain Architecture	No domain graphic available
Description	Zinc finger protein 16 (Zinc finger protein KOX9).

ZN669_HUMAN
NC score	0.006496 (rank : 226)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	131	Target Neighborhood Hits	746	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BR6, Q5VT39, Q9H9Q6	Gene names	ZNF669
Domain Architecture	No domain graphic available
Description	Zinc finger protein 669.

CCND3_MOUSE
NC score	0.006161 (rank : 227)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	131	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	P30282, Q62391, Q99KP2	Gene names	Ccnd3, Cyl-3
Domain Architecture
Description	G1/S-specific cyclin-D3.

FCN1_MOUSE
NC score	0.001437 (rank : 228)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	131	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).