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Network neighborhood for query Sequence : HDAC1_HUMAN

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HDAC1_HUMAN
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HDAC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

HDAC1_MOUSE
θ value	0 (rank : 2)	NC score	0.999309 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	44
SwissProt Accessions	O09106, P97476	Gene names	Hdac1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

HDAC2_HUMAN
θ value	0 (rank : 3)	NC score	0.995952 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q92769, Q5SRI8, Q5SZ86, Q8NEH4	Gene names	HDAC2
Domain Architecture
Description	Histone deacetylase 2 (HD2).

HDAC2_MOUSE
θ value	0 (rank : 4)	NC score	0.995897 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P70288	Gene names	Hdac2, Yy1bp
Domain Architecture
Description	Histone deacetylase 2 (HD2) (YY1 transcription factor-binding protein).

HDAC3_MOUSE
θ value	1.79118e-157 (rank : 5)	NC score	0.989976 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	O88895, O88896	Gene names	Hdac3
Domain Architecture
Description	Histone deacetylase 3 (HD3).

HDAC3_HUMAN
θ value	3.99034e-157 (rank : 6)	NC score	0.989703 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	O15379, O43268, Q9UEI5, Q9UEV0	Gene names	HDAC3
Domain Architecture
Description	Histone deacetylase 3 (HD3) (RPD3-2) (SMAP45).

HDAC8_MOUSE
θ value	1.76739e-88 (rank : 7)	NC score	0.971442 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VH37, Q3V270, Q9D0K6	Gene names	Hdac8
Domain Architecture
Description	Histone deacetylase 8 (HD8).

HDAC8_HUMAN
θ value	8.77142e-88 (rank : 8)	NC score	0.971410 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BY41, Q9NP76, Q9NYH4	Gene names	HDAC8, HDACL1
Domain Architecture
Description	Histone deacetylase 8 (HD8).

HDAC9_HUMAN
θ value	8.93572e-24 (rank : 9)	NC score	0.672772 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

HDAC7_HUMAN
θ value	1.5242e-23 (rank : 10)	NC score	0.708461 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUI4, Q7Z5I1, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7	Gene names	HDAC7A, HDAC7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

HDAC5_MOUSE
θ value	4.43474e-23 (rank : 11)	NC score	0.668846 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

HDAC7_MOUSE
θ value	4.43474e-23 (rank : 12)	NC score	0.707168 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

HDAC5_HUMAN
θ value	9.87957e-23 (rank : 13)	NC score	0.657253 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	353	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

HDAC4_HUMAN
θ value	2.87452e-22 (rank : 14)	NC score	0.655405 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	390	Shared Neighborhood Hits	20
SwissProt Accessions	P56524, Q9UND6	Gene names	HDAC4, KIAA0288
Domain Architecture
Description	Histone deacetylase 4 (HD4).

HDAC6_HUMAN
θ value	1.42661e-21 (rank : 15)	NC score	0.684692 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	145	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

HDAC6_MOUSE
θ value	5.42112e-21 (rank : 16)	NC score	0.692513 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

HDA10_HUMAN
θ value	1.33526e-19 (rank : 17)	NC score	0.719344 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	44	Shared Neighborhood Hits	20
SwissProt Accessions	Q969S8, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2	Gene names	HDAC10
Domain Architecture
Description	Histone deacetylase 10 (HD10).

HDA10_MOUSE
θ value	3.28887e-18 (rank : 18)	NC score	0.716080 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q6P3E7	Gene names	Hdac10
Domain Architecture	No domain graphic available
Description	Histone deacetylase 10 (HD10).

HDA11_MOUSE
θ value	3.76295e-14 (rank : 19)	NC score	0.720697 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WA3	Gene names	Hdac11
Domain Architecture
Description	Histone deacetylase 11 (HD11).

HDA11_HUMAN
θ value	1.42992e-13 (rank : 20)	NC score	0.714443 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	Q96DB2, Q9H6I7, Q9H6X3, Q9NTC9	Gene names	HDAC11
Domain Architecture
Description	Histone deacetylase 11 (HD11).

NSBP1_MOUSE
θ value	0.0736092 (rank : 21)	NC score	0.044290 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	681	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

IWS1_MOUSE
θ value	0.0961366 (rank : 22)	NC score	0.028651 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	1258	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LEO1_HUMAN
θ value	0.365318 (rank : 23)	NC score	0.047132 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	958	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

ERIC1_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.050599 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

NKTR_MOUSE
θ value	0.62314 (rank : 25)	NC score	0.018551 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	417	Shared Neighborhood Hits	16
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

MPP8_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.015634 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	948	Shared Neighborhood Hits	13
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

F10A1_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.029156 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	312	Shared Neighborhood Hits	10
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

F10A5_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.030218 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	277	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

IBP4_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.013872 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

MYST4_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.015981 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	416	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

ESCO1_HUMAN
θ value	1.81305 (rank : 31)	NC score	0.018590 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	361	Shared Neighborhood Hits	8
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

TSH2_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.015014 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	479	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

DCDC2_MOUSE
θ value	2.36792 (rank : 33)	NC score	0.020091 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	247	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DU00, Q5SZU0, Q80Y99	Gene names	Dcdc2, Kiaa1154
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 2.

AHI1_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.007842 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	537	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

RFC1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.020891 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	352	Shared Neighborhood Hits	8
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

ANKZ1_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.023680 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

ANR11_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.004821 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	1289	Shared Neighborhood Hits	17
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

LEO1_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.051600 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	946	Shared Neighborhood Hits	20
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PLCB4_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.010784 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	658	Shared Neighborhood Hits	12
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

STX3_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.005970 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q64704	Gene names	Stx3, Stx3a
Domain Architecture
Description	Syntaxin-3.

UBF1_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.023530 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	419	Shared Neighborhood Hits	16
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

CJ078_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.015795 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	559	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

ACE2_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.008733 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0I0, Q99N70, Q99N71	Gene names	Ace2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase).

TCAL5_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.019745 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	806	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

UBF1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.022164 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	415	Shared Neighborhood Hits	15
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

WEE1_MOUSE
θ value	6.88961 (rank : 46)	NC score	-0.000461 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	794	Shared Neighborhood Hits	4
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

ZCPW1_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.011721 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	307	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

PININ_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.011768 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	753	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

WEE1_HUMAN
θ value	8.99809 (rank : 49)	NC score	-0.000497 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	777	Shared Neighborhood Hits	4
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

HDAC9_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.247096 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	186	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

Hits sorted by NC score

HDAC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q13547, Q92534	Gene names	HDAC1, RPD3L1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

HDAC1_MOUSE
NC score	0.999309 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	46	Shared Neighborhood Hits	44
SwissProt Accessions	O09106, P97476	Gene names	Hdac1
Domain Architecture
Description	Histone deacetylase 1 (HD1).

HDAC2_HUMAN
NC score	0.995952 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q92769, Q5SRI8, Q5SZ86, Q8NEH4	Gene names	HDAC2
Domain Architecture
Description	Histone deacetylase 2 (HD2).

HDAC2_MOUSE
NC score	0.995897 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P70288	Gene names	Hdac2, Yy1bp
Domain Architecture
Description	Histone deacetylase 2 (HD2) (YY1 transcription factor-binding protein).

HDAC3_MOUSE
NC score	0.989976 (rank : 5)	θ value	1.79118e-157 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	O88895, O88896	Gene names	Hdac3
Domain Architecture
Description	Histone deacetylase 3 (HD3).

HDAC3_HUMAN
NC score	0.989703 (rank : 6)	θ value	3.99034e-157 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	O15379, O43268, Q9UEI5, Q9UEV0	Gene names	HDAC3
Domain Architecture
Description	Histone deacetylase 3 (HD3) (RPD3-2) (SMAP45).

HDAC8_MOUSE
NC score	0.971442 (rank : 7)	θ value	1.76739e-88 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VH37, Q3V270, Q9D0K6	Gene names	Hdac8
Domain Architecture
Description	Histone deacetylase 8 (HD8).

HDAC8_HUMAN
NC score	0.971410 (rank : 8)	θ value	8.77142e-88 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BY41, Q9NP76, Q9NYH4	Gene names	HDAC8, HDACL1
Domain Architecture
Description	Histone deacetylase 8 (HD8).

HDA11_MOUSE
NC score	0.720697 (rank : 9)	θ value	3.76295e-14 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WA3	Gene names	Hdac11
Domain Architecture
Description	Histone deacetylase 11 (HD11).

HDA10_HUMAN
NC score	0.719344 (rank : 10)	θ value	1.33526e-19 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	44	Shared Neighborhood Hits	20
SwissProt Accessions	Q969S8, Q6STF9, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2	Gene names	HDAC10
Domain Architecture
Description	Histone deacetylase 10 (HD10).

HDA10_MOUSE
NC score	0.716080 (rank : 11)	θ value	3.28887e-18 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q6P3E7	Gene names	Hdac10
Domain Architecture	No domain graphic available
Description	Histone deacetylase 10 (HD10).

HDA11_HUMAN
NC score	0.714443 (rank : 12)	θ value	1.42992e-13 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	21	Shared Neighborhood Hits	20
SwissProt Accessions	Q96DB2, Q9H6I7, Q9H6X3, Q9NTC9	Gene names	HDAC11
Domain Architecture
Description	Histone deacetylase 11 (HD11).

HDAC7_HUMAN
NC score	0.708461 (rank : 13)	θ value	1.5242e-23 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUI4, Q7Z5I1, Q96K01, Q9BR73, Q9H7L0, Q9NW41, Q9NWA9, Q9NYK9, Q9UFU7	Gene names	HDAC7A, HDAC7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

HDAC7_MOUSE
NC score	0.707168 (rank : 14)	θ value	4.43474e-23 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

HDAC6_MOUSE
NC score	0.692513 (rank : 15)	θ value	5.42112e-21 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

HDAC6_HUMAN
NC score	0.684692 (rank : 16)	θ value	1.42661e-21 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	145	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

HDAC9_HUMAN
NC score	0.672772 (rank : 17)	θ value	8.93572e-24 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

HDAC5_MOUSE
NC score	0.668846 (rank : 18)	θ value	4.43474e-23 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

HDAC5_HUMAN
NC score	0.657253 (rank : 19)	θ value	9.87957e-23 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	353	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

HDAC4_HUMAN
NC score	0.655405 (rank : 20)	θ value	2.87452e-22 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	390	Shared Neighborhood Hits	20
SwissProt Accessions	P56524, Q9UND6	Gene names	HDAC4, KIAA0288
Domain Architecture
Description	Histone deacetylase 4 (HD4).

HDAC9_MOUSE
NC score	0.247096 (rank : 21)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	186	Shared Neighborhood Hits	7
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

LEO1_MOUSE
NC score	0.051600 (rank : 22)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	946	Shared Neighborhood Hits	20
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

ERIC1_HUMAN
NC score	0.050599 (rank : 23)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	364	Shared Neighborhood Hits	15
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

LEO1_HUMAN
NC score	0.047132 (rank : 24)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	958	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

NSBP1_MOUSE
NC score	0.044290 (rank : 25)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	681	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

F10A5_HUMAN
NC score	0.030218 (rank : 26)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	277	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

F10A1_HUMAN
NC score	0.029156 (rank : 27)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	312	Shared Neighborhood Hits	10
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

IWS1_MOUSE
NC score	0.028651 (rank : 28)	θ value	0.0961366 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	1258	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ANKZ1_HUMAN
NC score	0.023680 (rank : 29)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	236	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

UBF1_MOUSE
NC score	0.023530 (rank : 30)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	419	Shared Neighborhood Hits	16
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

UBF1_HUMAN
NC score	0.022164 (rank : 31)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	415	Shared Neighborhood Hits	15
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

RFC1_HUMAN
NC score	0.020891 (rank : 32)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	352	Shared Neighborhood Hits	8
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

DCDC2_MOUSE
NC score	0.020091 (rank : 33)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	247	Shared Neighborhood Hits	12
SwissProt Accessions	Q5DU00, Q5SZU0, Q80Y99	Gene names	Dcdc2, Kiaa1154
Domain Architecture	No domain graphic available
Description	Doublecortin domain-containing protein 2.

TCAL5_HUMAN
NC score	0.019745 (rank : 34)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	806	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ESCO1_HUMAN
NC score	0.018590 (rank : 35)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	361	Shared Neighborhood Hits	8
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

NKTR_MOUSE
NC score	0.018551 (rank : 36)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	417	Shared Neighborhood Hits	16
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

MYST4_MOUSE
NC score	0.015981 (rank : 37)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	416	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

CJ078_MOUSE
NC score	0.015795 (rank : 38)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	559	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

MPP8_HUMAN
NC score	0.015634 (rank : 39)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	948	Shared Neighborhood Hits	13
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

TSH2_HUMAN
NC score	0.015014 (rank : 40)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	479	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

IBP4_HUMAN
NC score	0.013872 (rank : 41)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

PININ_HUMAN
NC score	0.011768 (rank : 42)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	753	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

ZCPW1_MOUSE
NC score	0.011721 (rank : 43)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	307	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

PLCB4_HUMAN
NC score	0.010784 (rank : 44)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	658	Shared Neighborhood Hits	12
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

ACE2_MOUSE
NC score	0.008733 (rank : 45)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0I0, Q99N70, Q99N71	Gene names	Ace2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase).

AHI1_HUMAN
NC score	0.007842 (rank : 46)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	537	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

STX3_MOUSE
NC score	0.005970 (rank : 47)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	212	Shared Neighborhood Hits	5
SwissProt Accessions	Q64704	Gene names	Stx3, Stx3a
Domain Architecture
Description	Syntaxin-3.

ANR11_HUMAN
NC score	0.004821 (rank : 48)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	1289	Shared Neighborhood Hits	17
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

WEE1_MOUSE
NC score	-0.000461 (rank : 49)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	794	Shared Neighborhood Hits	4
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

WEE1_HUMAN
NC score	-0.000497 (rank : 50)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	777	Shared Neighborhood Hits	4
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).