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Network neighborhood for query Sequence : ISK3_MOUSE

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ISK3_MOUSE
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ISK3_MOUSE
θ value	8.61488e-35 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

IPK1_HUMAN
θ value	8.65492e-19 (rank : 2)	NC score	0.945155 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

IPK2_HUMAN
θ value	5.81887e-07 (rank : 3)	NC score	0.759001 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	P20155	Gene names	SPINK2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 2 precursor (Acrosin-trypsin inhibitor) (HUSI-II).

ISK5_HUMAN
θ value	8.40245e-06 (rank : 4)	NC score	0.527975 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

ISK4_MOUSE
θ value	1.87187e-05 (rank : 5)	NC score	0.678466 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	O35679	Gene names	Spink4, Mpgc60
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog) (MPGC60 protein).

IPK2_MOUSE
θ value	4.1701e-05 (rank : 6)	NC score	0.710643 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BMY7	Gene names	Spink2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 2 precursor.

ISK4_HUMAN
θ value	0.000121331 (rank : 7)	NC score	0.653794 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	O60575	Gene names	SPINK4
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog).

ISK7_HUMAN
θ value	0.000270298 (rank : 8)	NC score	0.611309 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P58062	Gene names	SPINK7, ECG2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

AGRIN_HUMAN
θ value	0.00102713 (rank : 9)	NC score	0.176982 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	582	Shared Neighborhood Hits	36
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ISK6_MOUSE
θ value	0.00869519 (rank : 10)	NC score	0.553347 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK7_MOUSE
θ value	0.0252991 (rank : 11)	NC score	0.506612 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q6IE32	Gene names	Spink7, Ecg2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

ISK6_HUMAN
θ value	0.21417 (rank : 12)	NC score	0.525595 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

FSTL5_HUMAN
θ value	0.279714 (rank : 13)	NC score	0.129971 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	347	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

TEFF2_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.253028 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	211	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

HTRA3_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.156751 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

SO5A1_HUMAN
θ value	0.365318 (rank : 16)	NC score	0.094766 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	57	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2Y9	Gene names	SLCO5A1, SLC21A15
Domain Architecture
Description	Solute carrier organic anion transporter family member 5A1 (Solute carrier family 21 member 15) (Organic anion transporter polypeptide- related protein 4) (OATP-RP4) (OATPRP4).

TEFF2_MOUSE
θ value	0.365318 (rank : 17)	NC score	0.249853 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

HTRA4_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.154031 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	119	Shared Neighborhood Hits	14
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

FST_MOUSE
θ value	1.06291 (rank : 19)	NC score	0.252945 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

HTRA3_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.137001 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	156	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

FST_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.245454 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

HTRA1_HUMAN
θ value	1.38821 (rank : 22)	NC score	0.149345 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	155	Shared Neighborhood Hits	22
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

SO4A1_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.082604 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7	Gene names	SLCO4A1, OATP1, OATPE, SLC21A12
Domain Architecture
Description	Solute carrier organic anion transporter family member 4A1 (Solute carrier family 21 member 12) (Sodium-independent organic anion transporter E) (Organic anion-transporting polypeptide E) (OATP-E) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT).

SPRL1_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.113745 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	231	Shared Neighborhood Hits	19
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

TICN3_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.121485 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

FSTL5_MOUSE
θ value	1.81305 (rank : 26)	NC score	0.123087 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	355	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

FSTL4_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.119535 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	344	Shared Neighborhood Hits	28
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

SO1A2_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.069941 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	P46721, Q9UGP7, Q9UL38	Gene names	SLCO1A2, OATP, SLC21A3
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A2 (Solute carrier family 21 member 3) (Sodium-independent organic anion transporter) (Organic anion-transporting polypeptide 1) (OATP1) (OATP- A).

HTRA1_MOUSE
θ value	3.0926 (rank : 29)	NC score	0.146196 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

TICN3_MOUSE
θ value	3.0926 (rank : 30)	NC score	0.124421 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

KAZD1_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.097614 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

SO4A1_MOUSE
θ value	5.27518 (rank : 32)	NC score	0.079175 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K078, Q8BZT4	Gene names	Slco4a1, Oatpe, Slc21a12
Domain Architecture
Description	Solute carrier organic anion transporter family member 4A1 (Solute carrier family 21 member 12) (Sodium-independent organic anion transporter E) (Organic anion-transporting polypeptide E) (OATP-E).

SPRL1_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.083381 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	403	Shared Neighborhood Hits	13
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

FSTL4_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.116775 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	333	Shared Neighborhood Hits	28
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

SO1A4_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.063126 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EP96	Gene names	Slco1a4, Oatp2, Slc21a5
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A4 (Solute carrier family 21 member 5) (Sodium-independent organic anion- transporting polypeptide 2).

SO1A5_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.061059 (rank : 54)
Query Neighborhood Hits	36	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YY5, Q91XS2	Gene names	Slco1a5, Oatp3, Slc21a7
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A5 (Solute carrier family 21 member 7) (Sodium-independent organic anion transporter 3) (Organic anion-transporting polypeptide 3).

FSTL1_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.181587 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.180353 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	74	Shared Neighborhood Hits	26
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

FSTL3_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.170501 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FSTL3_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.171323 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

HTRA2_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.100268 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.100547 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.099527 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	220	Shared Neighborhood Hits	18
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.088441 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	230	Shared Neighborhood Hits	18
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

KAZD1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.095821 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	248	Shared Neighborhood Hits	20
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

RECK_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.057046 (rank : 60)
Query Neighborhood Hits	36	Target Neighborhood Hits	189	Shared Neighborhood Hits	22
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

SMOC1_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.062608 (rank : 52)
Query Neighborhood Hits	36	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

SMOC1_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.062872 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SMOC2_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.050012 (rank : 69)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

SMOC2_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.059559 (rank : 58)
Query Neighborhood Hits	36	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

SO1A1_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.056457 (rank : 61)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXZ6	Gene names	Slco1a1, Slc21a1
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A1 (Solute carrier family 21 member 1) (Sodium-independent organic anion- transporting polypeptide 1) (OATP1).

SO1A6_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.061655 (rank : 53)
Query Neighborhood Hits	36	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q99J94, Q3UQC6, Q9CUP7	Gene names	Slco1a6, Oatp5, Slc21a13
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A6 (Solute carrier family 21 member 13) (Kidney-specific organic anion- transporting polypeptide 5) (OATP-5).

SO1B1_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.055477 (rank : 64)
Query Neighborhood Hits	36	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6L6, Q9NQ37, Q9UBF3, Q9UH89	Gene names	SLCO1B1, LST1, OATP2, OATPC, SLC21A6
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B1 (Solute carrier family 21 member 6) (Sodium-independent organic anion- transporting polypeptide 2) (OATP 2) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C).

SO1B2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.056317 (rank : 63)
Query Neighborhood Hits	36	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJL3, Q9JI79, Q9JJJ1	Gene names	Slco1b2, Slc21a10
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B2 (Solute carrier family 21 member 10) (Liver-specific organic anion transporter 1) (LST-1) (SLC21A6).

SO1B3_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.056360 (rank : 62)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPD5	Gene names	SLCO1B3, LST2, SLC21A8
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B3 (Solute carrier family 21 member 8) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP8) (Liver-specific organic anion transporter 2) (LST-2).

SO1C1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.053827 (rank : 66)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYB5	Gene names	SLCO1C1, OATPF, SLC21A14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5).

SO1C1_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.055372 (rank : 65)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERB5, Q8BX54	Gene names	Slco1c1, Oatpf, Slc21a14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter 2) (OATP2).

SO2A1_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.058978 (rank : 59)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	Q92959	Gene names	SLCO2A1, SLC21A2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

SO2A1_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.060149 (rank : 57)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPT5	Gene names	Slco2a1, Slc21a2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

SO2B1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.051017 (rank : 67)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	O94956, Q9H2Z0, Q9UFU1	Gene names	SLCO2B1, KIAA0880, OATPB, SLC21A9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2).

SO2B1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.050853 (rank : 68)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BXB6, Q8BLV8	Gene names	Slco2b1, Slc21a9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9).

SO3A1_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.060249 (rank : 56)
Query Neighborhood Hits	36	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UIG8, Q9BW73, Q9GZV2	Gene names	SLCO3A1, OATPD, SLC21A11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (PGE1 transporter).

SO3A1_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.060661 (rank : 55)
Query Neighborhood Hits	36	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R3L5, Q9CTV3, Q9JKV0	Gene names	Slco3a1, Oatpd, Slc21a11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (MJAM).

SPRC_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.081395 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRC_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.080134 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

TICN1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.082115 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.097066 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.083578 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TICN2_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.086087 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

Hits sorted by NC score

ISK3_MOUSE
NC score	0.999962 (rank : 1)	θ value	8.61488e-35 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

IPK1_HUMAN
NC score	0.945155 (rank : 2)	θ value	8.65492e-19 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

IPK2_HUMAN
NC score	0.759001 (rank : 3)	θ value	5.81887e-07 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	P20155	Gene names	SPINK2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 2 precursor (Acrosin-trypsin inhibitor) (HUSI-II).

IPK2_MOUSE
NC score	0.710643 (rank : 4)	θ value	4.1701e-05 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BMY7	Gene names	Spink2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 2 precursor.

ISK4_MOUSE
NC score	0.678466 (rank : 5)	θ value	1.87187e-05 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	O35679	Gene names	Spink4, Mpgc60
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog) (MPGC60 protein).

ISK4_HUMAN
NC score	0.653794 (rank : 6)	θ value	0.000121331 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	O60575	Gene names	SPINK4
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog).

ISK7_HUMAN
NC score	0.611309 (rank : 7)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	P58062	Gene names	SPINK7, ECG2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

ISK6_MOUSE
NC score	0.553347 (rank : 8)	θ value	0.00869519 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK5_HUMAN
NC score	0.527975 (rank : 9)	θ value	8.40245e-06 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

ISK6_HUMAN
NC score	0.525595 (rank : 10)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK7_MOUSE
NC score	0.506612 (rank : 11)	θ value	0.0252991 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	Q6IE32	Gene names	Spink7, Ecg2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

TEFF2_HUMAN
NC score	0.253028 (rank : 12)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	211	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

FST_MOUSE
NC score	0.252945 (rank : 13)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

TEFF2_MOUSE
NC score	0.249853 (rank : 14)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

FST_HUMAN
NC score	0.245454 (rank : 15)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

FSTL1_HUMAN
NC score	0.181587 (rank : 16)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
NC score	0.180353 (rank : 17)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	74	Shared Neighborhood Hits	26
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

AGRIN_HUMAN
NC score	0.176982 (rank : 18)	θ value	0.00102713 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	582	Shared Neighborhood Hits	36
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

FSTL3_MOUSE
NC score	0.171323 (rank : 19)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FSTL3_HUMAN
NC score	0.170501 (rank : 20)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	162	Shared Neighborhood Hits	28
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

HTRA3_HUMAN
NC score	0.156751 (rank : 21)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	152	Shared Neighborhood Hits	19
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA4_HUMAN
NC score	0.154031 (rank : 22)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	119	Shared Neighborhood Hits	14
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA1_HUMAN
NC score	0.149345 (rank : 23)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	155	Shared Neighborhood Hits	22
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
NC score	0.146196 (rank : 24)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	140	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA3_MOUSE
NC score	0.137001 (rank : 25)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	156	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

FSTL5_HUMAN
NC score	0.129971 (rank : 26)	θ value	0.279714 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	347	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

TICN3_MOUSE
NC score	0.124421 (rank : 27)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

FSTL5_MOUSE
NC score	0.123087 (rank : 28)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	355	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

TICN3_HUMAN
NC score	0.121485 (rank : 29)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

FSTL4_HUMAN
NC score	0.119535 (rank : 30)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	344	Shared Neighborhood Hits	28
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
NC score	0.116775 (rank : 31)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	333	Shared Neighborhood Hits	28
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

SPRL1_HUMAN
NC score	0.113745 (rank : 32)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	231	Shared Neighborhood Hits	19
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

HTRA2_MOUSE
NC score	0.100547 (rank : 33)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
NC score	0.100268 (rank : 34)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_HUMAN
NC score	0.099527 (rank : 35)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	220	Shared Neighborhood Hits	18
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

KAZD1_MOUSE
NC score	0.097614 (rank : 36)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

TICN1_MOUSE
NC score	0.097066 (rank : 37)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	36	Target Neighborhood Hits	79	Shared Neighborhood Hits	24
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

KAZD1_HUMAN
NC score	0.095821 (rank : 38)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	248	Shared Neighborhood Hits	20
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

SO5A1_HUMAN
NC score	0.094766 (rank : 39)	θ value	0.365318 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	57	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H2Y9	Gene names	SLCO5A1, SLC21A15
Domain Architecture
Description	Solute carrier organic anion transporter family member 5A1 (Solute carrier family 21 member 15) (Organic anion transporter polypeptide- related protein 4) (OATP-RP4) (OATPRP4).

IBP7_MOUSE
NC score	0.088441 (rank : 40)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	230	Shared Neighborhood Hits	18
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

TICN2_MOUSE
NC score	0.086087 (rank : 41)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	36	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TICN2_HUMAN
NC score	0.083578 (rank : 42)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

SPRL1_MOUSE
NC score	0.083381 (rank : 43)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	403	Shared Neighborhood Hits	13
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

SO4A1_HUMAN
NC score	0.082604 (rank : 44)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q96BD0, Q9H4T7, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7	Gene names	SLCO4A1, OATP1, OATPE, SLC21A12
Domain Architecture
Description	Solute carrier organic anion transporter family member 4A1 (Solute carrier family 21 member 12) (Sodium-independent organic anion transporter E) (Organic anion-transporting polypeptide E) (OATP-E) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT).

TICN1_HUMAN
NC score	0.082115 (rank : 45)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

SPRC_HUMAN
NC score	0.081395 (rank : 46)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	36	Target Neighborhood Hits	45	Shared Neighborhood Hits	10
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRC_MOUSE
NC score	0.080134 (rank : 47)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	36	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SO4A1_MOUSE
NC score	0.079175 (rank : 48)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K078, Q8BZT4	Gene names	Slco4a1, Oatpe, Slc21a12
Domain Architecture
Description	Solute carrier organic anion transporter family member 4A1 (Solute carrier family 21 member 12) (Sodium-independent organic anion transporter E) (Organic anion-transporting polypeptide E) (OATP-E).

SO1A2_HUMAN
NC score	0.069941 (rank : 49)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	13
SwissProt Accessions	P46721, Q9UGP7, Q9UL38	Gene names	SLCO1A2, OATP, SLC21A3
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A2 (Solute carrier family 21 member 3) (Sodium-independent organic anion transporter) (Organic anion-transporting polypeptide 1) (OATP1) (OATP- A).

SO1A4_MOUSE
NC score	0.063126 (rank : 50)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EP96	Gene names	Slco1a4, Oatp2, Slc21a5
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A4 (Solute carrier family 21 member 5) (Sodium-independent organic anion- transporting polypeptide 2).

SMOC1_MOUSE
NC score	0.062872 (rank : 51)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	74	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SMOC1_HUMAN
NC score	0.062608 (rank : 52)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

SO1A6_MOUSE
NC score	0.061655 (rank : 53)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	36	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	Q99J94, Q3UQC6, Q9CUP7	Gene names	Slco1a6, Oatp5, Slc21a13
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A6 (Solute carrier family 21 member 13) (Kidney-specific organic anion- transporting polypeptide 5) (OATP-5).

SO1A5_MOUSE
NC score	0.061059 (rank : 54)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	31	Shared Neighborhood Hits	12
SwissProt Accessions	Q91YY5, Q91XS2	Gene names	Slco1a5, Oatp3, Slc21a7
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A5 (Solute carrier family 21 member 7) (Sodium-independent organic anion transporter 3) (Organic anion-transporting polypeptide 3).

SO3A1_MOUSE
NC score	0.060661 (rank : 55)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	36	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R3L5, Q9CTV3, Q9JKV0	Gene names	Slco3a1, Oatpd, Slc21a11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (MJAM).

SO3A1_HUMAN
NC score	0.060249 (rank : 56)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	36	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UIG8, Q9BW73, Q9GZV2	Gene names	SLCO3A1, OATPD, SLC21A11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (PGE1 transporter).

SO2A1_MOUSE
NC score	0.060149 (rank : 57)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	36	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPT5	Gene names	Slco2a1, Slc21a2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

SMOC2_MOUSE
NC score	0.059559 (rank : 58)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	81	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

SO2A1_HUMAN
NC score	0.058978 (rank : 59)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	36	Target Neighborhood Hits	40	Shared Neighborhood Hits	10
SwissProt Accessions	Q92959	Gene names	SLCO2A1, SLC21A2
Domain Architecture
Description	Solute carrier organic anion transporter family member 2A1 (Solute carrier family 21 member 2) (Prostaglandin transporter) (PGT).

RECK_HUMAN
NC score	0.057046 (rank : 60)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	189	Shared Neighborhood Hits	22
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

SO1A1_MOUSE
NC score	0.056457 (rank : 61)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	28	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QXZ6	Gene names	Slco1a1, Slc21a1
Domain Architecture
Description	Solute carrier organic anion transporter family member 1A1 (Solute carrier family 21 member 1) (Sodium-independent organic anion- transporting polypeptide 1) (OATP1).

SO1B3_HUMAN
NC score	0.056360 (rank : 62)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPD5	Gene names	SLCO1B3, LST2, SLC21A8
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B3 (Solute carrier family 21 member 8) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP8) (Liver-specific organic anion transporter 2) (LST-2).

SO1B2_MOUSE
NC score	0.056317 (rank : 63)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	36	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JJL3, Q9JI79, Q9JJJ1	Gene names	Slco1b2, Slc21a10
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B2 (Solute carrier family 21 member 10) (Liver-specific organic anion transporter 1) (LST-1) (SLC21A6).

SO1B1_HUMAN
NC score	0.055477 (rank : 64)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	36	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6L6, Q9NQ37, Q9UBF3, Q9UH89	Gene names	SLCO1B1, LST1, OATP2, OATPC, SLC21A6
Domain Architecture
Description	Solute carrier organic anion transporter family member 1B1 (Solute carrier family 21 member 6) (Sodium-independent organic anion- transporting polypeptide 2) (OATP 2) (Liver-specific organic anion transporter 1) (LST-1) (OATP-C).

SO1C1_MOUSE
NC score	0.055372 (rank : 65)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ERB5, Q8BX54	Gene names	Slco1c1, Oatpf, Slc21a14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter 2) (OATP2).

SO1C1_HUMAN
NC score	0.053827 (rank : 66)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYB5	Gene names	SLCO1C1, OATPF, SLC21A14
Domain Architecture
Description	Solute carrier organic anion transporter family member 1C1 (Solute carrier family 21 member 14) (Organic anion transporter F) (OATP-F) (Organic anion-transporting polypeptide 14) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5).

SO2B1_HUMAN
NC score	0.051017 (rank : 67)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	36	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	O94956, Q9H2Z0, Q9UFU1	Gene names	SLCO2B1, KIAA0880, OATPB, SLC21A9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2).

SO2B1_MOUSE
NC score	0.050853 (rank : 68)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	36	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BXB6, Q8BLV8	Gene names	Slco2b1, Slc21a9
Domain Architecture
Description	Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9).

SMOC2_HUMAN
NC score	0.050012 (rank : 69)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).