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Network neighborhood for query Sequence : ACOT1_HUMAN

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ACOT1_HUMAN
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ACOT1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

ACOT2_HUMAN
θ value	0 (rank : 2)	NC score	0.999777 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

ACOT3_MOUSE
θ value	0 (rank : 3)	NC score	0.998722 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QYR7, Q6Q2Z7	Gene names	Acot3, Pte1a, Pte2, Pte2a
Domain Architecture
Description	Acyl-coenzyme A thioesterase 3 (EC 3.1.2.2) (Acyl-CoA thioesterase 3) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (PTE-Ia).

ACOT1_MOUSE
θ value	1.60882e-182 (rank : 4)	NC score	0.998237 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	O55137, Q549A9	Gene names	Acot1, Cte1
Domain Architecture
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I).

ACOT2_MOUSE
θ value	3.58407e-182 (rank : 5)	NC score	0.998210 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYR9	Gene names	Acot2, Mte1
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2, mitochondrial precursor (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Acyl coenzyme A thioester hydrolase) (Very- long-chain acyl-CoA thioesterase) (MTE-I).

ACOT5_MOUSE
θ value	2.83983e-179 (rank : 6)	NC score	0.998313 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6Q2Z6	Gene names	Acot5
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 5 (EC 3.1.2.2) (Acyl-CoA thioesterase 5) (Peroxisomal acyl-coenzyme A thioester hydrolase Ic) (Peroxisomal acyl-CoA thioesterase Ic).

ACOT4_HUMAN
θ value	3.47952e-169 (rank : 7)	NC score	0.997548 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N9L9, Q86TX0, Q86TX1, Q96N88	Gene names	ACOT4, PTE2B, PTEIB
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 4 (EC 3.1.2.2) (Acyl-CoA thioesterase 4) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-coA thioesterase Ib) (PTE-Ib) (PTE-2b).

ACOT4_MOUSE
θ value	1.12453e-151 (rank : 8)	NC score	0.996504 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BWN8, Q8BJQ1, Q8BL20, Q9QYR8	Gene names	Acot4, Pte1b, Pte2b
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 4 (EC 3.1.2.2) (Acyl-CoA thioesterase 4) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-coA thioesterase Ib) (PTE-Ib) (PTE-2b).

BAAT_MOUSE
θ value	8.47616e-91 (rank : 9)	NC score	0.975699 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q91X34, O08833, Q8C1I3	Gene names	Baat
Domain Architecture	No domain graphic available
Description	Bile acid CoA:amino acid N-acyltransferase (EC 2.3.1.65) (BAT) (BACAT) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2).

BAAT_HUMAN
θ value	4.07447e-85 (rank : 10)	NC score	0.972607 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q14032, Q96L31	Gene names	BAAT
Domain Architecture	No domain graphic available
Description	Bile acid CoA:amino acid N-acyltransferase (EC 2.3.1.65) (BAT) (BACAT) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2).

ABTAP_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.025181 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	290	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

TIAM1_MOUSE
θ value	2.36792 (rank : 12)	NC score	0.023699 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ALAT2_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.013007 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TD30, Q8N9E2	Gene names	GPT2, AAT2
Domain Architecture	No domain graphic available
Description	Alanine aminotransferase 2 (EC 2.6.1.2) (ALT2) (Glutamic--pyruvic transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2).

FA47A_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.005860 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	451	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FARP2_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.008043 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	240	Shared Neighborhood Hits	5
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.007743 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	209	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

Hits sorted by NC score

ACOT1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

ACOT2_HUMAN
NC score	0.999777 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

ACOT3_MOUSE
NC score	0.998722 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QYR7, Q6Q2Z7	Gene names	Acot3, Pte1a, Pte2, Pte2a
Domain Architecture
Description	Acyl-coenzyme A thioesterase 3 (EC 3.1.2.2) (Acyl-CoA thioesterase 3) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (PTE-Ia).

ACOT5_MOUSE
NC score	0.998313 (rank : 4)	θ value	2.83983e-179 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q6Q2Z6	Gene names	Acot5
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 5 (EC 3.1.2.2) (Acyl-CoA thioesterase 5) (Peroxisomal acyl-coenzyme A thioester hydrolase Ic) (Peroxisomal acyl-CoA thioesterase Ic).

ACOT1_MOUSE
NC score	0.998237 (rank : 5)	θ value	1.60882e-182 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	O55137, Q549A9	Gene names	Acot1, Cte1
Domain Architecture
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I).

ACOT2_MOUSE
NC score	0.998210 (rank : 6)	θ value	3.58407e-182 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYR9	Gene names	Acot2, Mte1
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2, mitochondrial precursor (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Acyl coenzyme A thioester hydrolase) (Very- long-chain acyl-CoA thioesterase) (MTE-I).

ACOT4_HUMAN
NC score	0.997548 (rank : 7)	θ value	3.47952e-169 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N9L9, Q86TX0, Q86TX1, Q96N88	Gene names	ACOT4, PTE2B, PTEIB
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 4 (EC 3.1.2.2) (Acyl-CoA thioesterase 4) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-coA thioesterase Ib) (PTE-Ib) (PTE-2b).

ACOT4_MOUSE
NC score	0.996504 (rank : 8)	θ value	1.12453e-151 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BWN8, Q8BJQ1, Q8BL20, Q9QYR8	Gene names	Acot4, Pte1b, Pte2b
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 4 (EC 3.1.2.2) (Acyl-CoA thioesterase 4) (Peroxisomal acyl coenzyme A thioester hydrolase Ib) (Peroxisomal long-chain acyl-coA thioesterase Ib) (PTE-Ib) (PTE-2b).

BAAT_MOUSE
NC score	0.975699 (rank : 9)	θ value	8.47616e-91 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q91X34, O08833, Q8C1I3	Gene names	Baat
Domain Architecture	No domain graphic available
Description	Bile acid CoA:amino acid N-acyltransferase (EC 2.3.1.65) (BAT) (BACAT) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2).

BAAT_HUMAN
NC score	0.972607 (rank : 10)	θ value	4.07447e-85 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q14032, Q96L31	Gene names	BAAT
Domain Architecture	No domain graphic available
Description	Bile acid CoA:amino acid N-acyltransferase (EC 2.3.1.65) (BAT) (BACAT) (Glycine N-choloyltransferase) (Long-chain fatty-acyl-CoA hydrolase) (EC 3.1.2.2).

ABTAP_HUMAN
NC score	0.025181 (rank : 11)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	290	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

TIAM1_MOUSE
NC score	0.023699 (rank : 12)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ALAT2_HUMAN
NC score	0.013007 (rank : 13)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TD30, Q8N9E2	Gene names	GPT2, AAT2
Domain Architecture	No domain graphic available
Description	Alanine aminotransferase 2 (EC 2.6.1.2) (ALT2) (Glutamic--pyruvic transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2).

FARP2_HUMAN
NC score	0.008043 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	240	Shared Neighborhood Hits	5
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.007743 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	209	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FA47A_HUMAN
NC score	0.005860 (rank : 16)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	451	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.