Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : NPHP1_HUMAN

For an explanation of this page, click here

NPHP1_HUMAN
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPHP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	288	Target Neighborhood Hits	288	Shared Neighborhood Hits	288
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	0 (rank : 2)	NC score	0.923972 (rank : 2)
Query Neighborhood Hits	288	Target Neighborhood Hits	267	Shared Neighborhood Hits	186
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CRK_HUMAN
θ value	2.61198e-07 (rank : 3)	NC score	0.525456 (rank : 6)
Query Neighborhood Hits	288	Target Neighborhood Hits	308	Shared Neighborhood Hits	169
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	2.61198e-07 (rank : 4)	NC score	0.527125 (rank : 5)
Query Neighborhood Hits	288	Target Neighborhood Hits	314	Shared Neighborhood Hits	168
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
θ value	7.59969e-07 (rank : 5)	NC score	0.537539 (rank : 3)
Query Neighborhood Hits	288	Target Neighborhood Hits	313	Shared Neighborhood Hits	173
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ITSN2_MOUSE
θ value	9.92553e-07 (rank : 6)	NC score	0.347897 (rank : 55)
Query Neighborhood Hits	288	Target Neighborhood Hits	1371	Shared Neighborhood Hits	235
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CRKL_MOUSE
θ value	1.29631e-06 (rank : 7)	NC score	0.534570 (rank : 4)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	170
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITSN2_HUMAN
θ value	1.69304e-06 (rank : 8)	NC score	0.361514 (rank : 53)
Query Neighborhood Hits	288	Target Neighborhood Hits	1173	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PPIP1_HUMAN
θ value	4.92598e-06 (rank : 9)	NC score	0.473512 (rank : 14)
Query Neighborhood Hits	288	Target Neighborhood Hits	389	Shared Neighborhood Hits	180
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	6.43352e-06 (rank : 10)	NC score	0.476414 (rank : 13)
Query Neighborhood Hits	288	Target Neighborhood Hits	377	Shared Neighborhood Hits	185
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

TEC_HUMAN
θ value	2.44474e-05 (rank : 11)	NC score	0.195268 (rank : 153)
Query Neighborhood Hits	288	Target Neighborhood Hits	1006	Shared Neighborhood Hits	146
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	3.19293e-05 (rank : 12)	NC score	0.195244 (rank : 154)
Query Neighborhood Hits	288	Target Neighborhood Hits	1006	Shared Neighborhood Hits	145
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_MOUSE
θ value	3.19293e-05 (rank : 13)	NC score	0.197246 (rank : 148)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	142
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

NCF1_MOUSE
θ value	5.44631e-05 (rank : 14)	NC score	0.465287 (rank : 15)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	145
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SRGP1_HUMAN
θ value	5.44631e-05 (rank : 15)	NC score	0.295714 (rank : 95)
Query Neighborhood Hits	288	Target Neighborhood Hits	390	Shared Neighborhood Hits	153
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ES8L1_MOUSE
θ value	9.29e-05 (rank : 16)	NC score	0.325557 (rank : 67)
Query Neighborhood Hits	288	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

AHI1_HUMAN
θ value	0.000121331 (rank : 17)	NC score	0.345856 (rank : 57)
Query Neighborhood Hits	288	Target Neighborhood Hits	537	Shared Neighborhood Hits	168
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITSN1_MOUSE
θ value	0.000121331 (rank : 18)	NC score	0.338646 (rank : 59)
Query Neighborhood Hits	288	Target Neighborhood Hits	1669	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

FNBP2_HUMAN
θ value	0.000158464 (rank : 19)	NC score	0.294281 (rank : 97)
Query Neighborhood Hits	288	Target Neighborhood Hits	432	Shared Neighborhood Hits	152
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NCF1_HUMAN
θ value	0.000158464 (rank : 20)	NC score	0.459407 (rank : 17)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	138
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

BTK_MOUSE
θ value	0.00020696 (rank : 21)	NC score	0.212392 (rank : 141)
Query Neighborhood Hits	288	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SRGP2_HUMAN
θ value	0.00020696 (rank : 22)	NC score	0.294147 (rank : 98)
Query Neighborhood Hits	288	Target Neighborhood Hits	331	Shared Neighborhood Hits	141
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ITSN1_HUMAN
θ value	0.000270298 (rank : 23)	NC score	0.335453 (rank : 62)
Query Neighborhood Hits	288	Target Neighborhood Hits	1757	Shared Neighborhood Hits	246
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

TXK_HUMAN
θ value	0.000270298 (rank : 24)	NC score	0.189316 (rank : 163)
Query Neighborhood Hits	288	Target Neighborhood Hits	971	Shared Neighborhood Hits	134
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

YES_HUMAN
θ value	0.000270298 (rank : 25)	NC score	0.225267 (rank : 129)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	171
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CSK_HUMAN
θ value	0.00035302 (rank : 26)	NC score	0.176950 (rank : 177)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	131
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.00035302 (rank : 27)	NC score	0.177090 (rank : 176)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	131
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

GRB2_HUMAN
θ value	0.00035302 (rank : 28)	NC score	0.510268 (rank : 7)
Query Neighborhood Hits	288	Target Neighborhood Hits	310	Shared Neighborhood Hits	170
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00035302 (rank : 29)	NC score	0.509846 (rank : 8)
Query Neighborhood Hits	288	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

YES_MOUSE
θ value	0.00035302 (rank : 30)	NC score	0.225853 (rank : 127)
Query Neighborhood Hits	288	Target Neighborhood Hits	1052	Shared Neighborhood Hits	172
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

GRAP_HUMAN
θ value	0.000461057 (rank : 31)	NC score	0.506932 (rank : 9)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	174
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SRGP2_MOUSE
θ value	0.000461057 (rank : 32)	NC score	0.296305 (rank : 93)
Query Neighborhood Hits	288	Target Neighborhood Hits	324	Shared Neighborhood Hits	143
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ANM2_HUMAN
θ value	0.000602161 (rank : 33)	NC score	0.309879 (rank : 81)
Query Neighborhood Hits	288	Target Neighborhood Hits	175	Shared Neighborhood Hits	135
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BTK_HUMAN
θ value	0.000602161 (rank : 34)	NC score	0.212859 (rank : 140)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	167
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PACN3_HUMAN
θ value	0.000786445 (rank : 35)	NC score	0.384068 (rank : 40)
Query Neighborhood Hits	288	Target Neighborhood Hits	385	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SRC_HUMAN
θ value	0.000786445 (rank : 36)	NC score	0.221859 (rank : 132)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ANM2_MOUSE
θ value	0.00102713 (rank : 37)	NC score	0.295124 (rank : 96)
Query Neighborhood Hits	288	Target Neighborhood Hits	175	Shared Neighborhood Hits	134
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

GRAP_MOUSE
θ value	0.00102713 (rank : 38)	NC score	0.501133 (rank : 11)
Query Neighborhood Hits	288	Target Neighborhood Hits	309	Shared Neighborhood Hits	173
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SEC63_HUMAN
θ value	0.00102713 (rank : 39)	NC score	0.088857 (rank : 389)
Query Neighborhood Hits	288	Target Neighborhood Hits	586	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

STAM2_HUMAN
θ value	0.00102713 (rank : 40)	NC score	0.430914 (rank : 22)
Query Neighborhood Hits	288	Target Neighborhood Hits	288	Shared Neighborhood Hits	167
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI2_HUMAN
θ value	0.00134147 (rank : 41)	NC score	0.422404 (rank : 28)
Query Neighborhood Hits	288	Target Neighborhood Hits	350	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.00134147 (rank : 42)	NC score	0.426690 (rank : 25)
Query Neighborhood Hits	288	Target Neighborhood Hits	266	Shared Neighborhood Hits	146
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF2_HUMAN
θ value	0.00134147 (rank : 43)	NC score	0.448677 (rank : 19)
Query Neighborhood Hits	288	Target Neighborhood Hits	229	Shared Neighborhood Hits	140
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCK2_HUMAN
θ value	0.00134147 (rank : 44)	NC score	0.506656 (rank : 10)
Query Neighborhood Hits	288	Target Neighborhood Hits	310	Shared Neighborhood Hits	172
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ABL2_HUMAN
θ value	0.00175202 (rank : 45)	NC score	0.177197 (rank : 174)
Query Neighborhood Hits	288	Target Neighborhood Hits	1045	Shared Neighborhood Hits	122
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PACN3_MOUSE
θ value	0.00175202 (rank : 46)	NC score	0.380607 (rank : 43)
Query Neighborhood Hits	288	Target Neighborhood Hits	380	Shared Neighborhood Hits	167
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

FGR_HUMAN
θ value	0.00228821 (rank : 47)	NC score	0.225658 (rank : 128)
Query Neighborhood Hits	288	Target Neighborhood Hits	1067	Shared Neighborhood Hits	164
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	0.00228821 (rank : 48)	NC score	0.224749 (rank : 130)
Query Neighborhood Hits	288	Target Neighborhood Hits	1069	Shared Neighborhood Hits	169
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STAM1_HUMAN
θ value	0.00228821 (rank : 49)	NC score	0.428002 (rank : 24)
Query Neighborhood Hits	288	Target Neighborhood Hits	271	Shared Neighborhood Hits	164
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

AHI1_MOUSE
θ value	0.00298849 (rank : 50)	NC score	0.335617 (rank : 61)
Query Neighborhood Hits	288	Target Neighborhood Hits	496	Shared Neighborhood Hits	164
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

STAM2_MOUSE
θ value	0.00298849 (rank : 51)	NC score	0.431412 (rank : 21)
Query Neighborhood Hits	288	Target Neighborhood Hits	285	Shared Neighborhood Hits	170
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PTK6_MOUSE
θ value	0.00390308 (rank : 52)	NC score	0.180580 (rank : 170)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

STAM1_MOUSE
θ value	0.00390308 (rank : 53)	NC score	0.428482 (rank : 23)
Query Neighborhood Hits	288	Target Neighborhood Hits	273	Shared Neighborhood Hits	164
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

FRK_HUMAN
θ value	0.00509761 (rank : 54)	NC score	0.192909 (rank : 158)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SEC63_MOUSE
θ value	0.00509761 (rank : 55)	NC score	0.087084 (rank : 408)
Query Neighborhood Hits	288	Target Neighborhood Hits	601	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SRC8_MOUSE
θ value	0.00509761 (rank : 56)	NC score	0.385718 (rank : 36)
Query Neighborhood Hits	288	Target Neighborhood Hits	292	Shared Neighborhood Hits	153
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ABI1_MOUSE
θ value	0.00665767 (rank : 57)	NC score	0.401482 (rank : 33)
Query Neighborhood Hits	288	Target Neighborhood Hits	246	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

DNMBP_MOUSE
θ value	0.00665767 (rank : 58)	NC score	0.363368 (rank : 51)
Query Neighborhood Hits	288	Target Neighborhood Hits	435	Shared Neighborhood Hits	167
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MYO1F_HUMAN
θ value	0.00665767 (rank : 59)	NC score	0.194567 (rank : 156)
Query Neighborhood Hits	288	Target Neighborhood Hits	275	Shared Neighborhood Hits	159
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

FYN_HUMAN
θ value	0.00869519 (rank : 60)	NC score	0.218188 (rank : 135)
Query Neighborhood Hits	288	Target Neighborhood Hits	1078	Shared Neighborhood Hits	170
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00869519 (rank : 61)	NC score	0.221555 (rank : 133)
Query Neighborhood Hits	288	Target Neighborhood Hits	1073	Shared Neighborhood Hits	170
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LYN_HUMAN
θ value	0.00869519 (rank : 62)	NC score	0.196035 (rank : 151)
Query Neighborhood Hits	288	Target Neighborhood Hits	1022	Shared Neighborhood Hits	152
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ITK_HUMAN
θ value	0.0113563 (rank : 63)	NC score	0.185988 (rank : 165)
Query Neighborhood Hits	288	Target Neighborhood Hits	1016	Shared Neighborhood Hits	139
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SH3K1_HUMAN
θ value	0.0113563 (rank : 64)	NC score	0.422842 (rank : 27)
Query Neighborhood Hits	288	Target Neighborhood Hits	341	Shared Neighborhood Hits	161
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SPN90_HUMAN
θ value	0.0113563 (rank : 65)	NC score	0.304331 (rank : 86)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	0.0113563 (rank : 66)	NC score	0.281988 (rank : 106)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA2_HUMAN
θ value	0.0113563 (rank : 67)	NC score	0.247907 (rank : 121)
Query Neighborhood Hits	288	Target Neighborhood Hits	888	Shared Neighborhood Hits	206
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ES8L2_MOUSE
θ value	0.0148317 (rank : 68)	NC score	0.322315 (rank : 73)
Query Neighborhood Hits	288	Target Neighborhood Hits	169	Shared Neighborhood Hits	118
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_MOUSE
θ value	0.0148317 (rank : 69)	NC score	0.363150 (rank : 52)
Query Neighborhood Hits	288	Target Neighborhood Hits	168	Shared Neighborhood Hits	125
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SPTA1_HUMAN
θ value	0.0148317 (rank : 70)	NC score	0.226086 (rank : 126)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	199
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ABL1_HUMAN
θ value	0.0193708 (rank : 71)	NC score	0.177570 (rank : 172)
Query Neighborhood Hits	288	Target Neighborhood Hits	1220	Shared Neighborhood Hits	135
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	0.0193708 (rank : 72)	NC score	0.177324 (rank : 173)
Query Neighborhood Hits	288	Target Neighborhood Hits	1178	Shared Neighborhood Hits	131
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BCAR1_MOUSE
θ value	0.0193708 (rank : 73)	NC score	0.300611 (rank : 87)
Query Neighborhood Hits	288	Target Neighborhood Hits	438	Shared Neighborhood Hits	140
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ES8L1_HUMAN
θ value	0.0193708 (rank : 74)	NC score	0.323139 (rank : 71)
Query Neighborhood Hits	288	Target Neighborhood Hits	162	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MPP6_HUMAN
θ value	0.0193708 (rank : 75)	NC score	0.150446 (rank : 193)
Query Neighborhood Hits	288	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0.0193708 (rank : 76)	NC score	0.147278 (rank : 197)
Query Neighborhood Hits	288	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MYO1E_HUMAN
θ value	0.0193708 (rank : 77)	NC score	0.185766 (rank : 166)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	164
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ABI1_HUMAN
θ value	0.0252991 (rank : 78)	NC score	0.382578 (rank : 42)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI3_MOUSE
θ value	0.0252991 (rank : 79)	NC score	0.377174 (rank : 45)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

BCAR1_HUMAN
θ value	0.0252991 (rank : 80)	NC score	0.289943 (rank : 101)
Query Neighborhood Hits	288	Target Neighborhood Hits	554	Shared Neighborhood Hits	143
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

MOR2A_MOUSE
θ value	0.0252991 (rank : 81)	NC score	0.046005 (rank : 967)
Query Neighborhood Hits	288	Target Neighborhood Hits	220	Shared Neighborhood Hits	17
SwissProt Accessions	Q69ZX6, Q5QNQ7, Q6P547	Gene names	Morc2a, Kiaa0852, Zcwcc1
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2A (Zinc finger CW-type coiled-coil domain protein 1).

CD2AP_HUMAN
θ value	0.0330416 (rank : 82)	NC score	0.433705 (rank : 20)
Query Neighborhood Hits	288	Target Neighborhood Hits	315	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NCK1_HUMAN
θ value	0.0330416 (rank : 83)	NC score	0.497520 (rank : 12)
Query Neighborhood Hits	288	Target Neighborhood Hits	312	Shared Neighborhood Hits	169
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3K1_MOUSE
θ value	0.0330416 (rank : 84)	NC score	0.421060 (rank : 29)
Query Neighborhood Hits	288	Target Neighborhood Hits	332	Shared Neighborhood Hits	163
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_HUMAN
θ value	0.0330416 (rank : 85)	NC score	0.406899 (rank : 32)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	0.0330416 (rank : 86)	NC score	0.384529 (rank : 38)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC_MOUSE
θ value	0.0330416 (rank : 87)	NC score	0.204150 (rank : 143)
Query Neighborhood Hits	288	Target Neighborhood Hits	1033	Shared Neighborhood Hits	154
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TRIO_HUMAN
θ value	0.0330416 (rank : 88)	NC score	0.092532 (rank : 362)
Query Neighborhood Hits	288	Target Neighborhood Hits	1580	Shared Neighborhood Hits	132
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

LYN_MOUSE
θ value	0.0431538 (rank : 89)	NC score	0.195399 (rank : 152)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	148
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PACN1_MOUSE
θ value	0.0431538 (rank : 90)	NC score	0.383831 (rank : 41)
Query Neighborhood Hits	288	Target Neighborhood Hits	283	Shared Neighborhood Hits	162
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

RHG04_HUMAN
θ value	0.0431538 (rank : 91)	NC score	0.305813 (rank : 85)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	148
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ABI3_HUMAN
θ value	0.0563607 (rank : 92)	NC score	0.369362 (rank : 48)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	124
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CD2AP_MOUSE
θ value	0.0563607 (rank : 93)	NC score	0.426653 (rank : 26)
Query Neighborhood Hits	288	Target Neighborhood Hits	336	Shared Neighborhood Hits	170
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ES8L2_HUMAN
θ value	0.0563607 (rank : 94)	NC score	0.323192 (rank : 70)
Query Neighborhood Hits	288	Target Neighborhood Hits	193	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MPP5_HUMAN
θ value	0.0563607 (rank : 95)	NC score	0.120581 (rank : 232)
Query Neighborhood Hits	288	Target Neighborhood Hits	231	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.0563607 (rank : 96)	NC score	0.119874 (rank : 233)
Query Neighborhood Hits	288	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SM1L2_HUMAN
θ value	0.0563607 (rank : 97)	NC score	0.083585 (rank : 437)
Query Neighborhood Hits	288	Target Neighborhood Hits	1019	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

STAC_HUMAN
θ value	0.0563607 (rank : 98)	NC score	0.377750 (rank : 44)
Query Neighborhood Hits	288	Target Neighborhood Hits	276	Shared Neighborhood Hits	151
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BLK_HUMAN
θ value	0.0736092 (rank : 99)	NC score	0.194608 (rank : 155)
Query Neighborhood Hits	288	Target Neighborhood Hits	994	Shared Neighborhood Hits	138
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	0.0736092 (rank : 100)	NC score	0.196055 (rank : 150)
Query Neighborhood Hits	288	Target Neighborhood Hits	992	Shared Neighborhood Hits	132
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EPS8_HUMAN
θ value	0.0736092 (rank : 101)	NC score	0.286370 (rank : 105)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	0.0736092 (rank : 102)	NC score	0.292539 (rank : 100)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

IASPP_HUMAN
θ value	0.0736092 (rank : 103)	NC score	0.217671 (rank : 137)
Query Neighborhood Hits	288	Target Neighborhood Hits	688	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

M3K10_HUMAN
θ value	0.0736092 (rank : 104)	NC score	0.141386 (rank : 205)
Query Neighborhood Hits	288	Target Neighborhood Hits	1071	Shared Neighborhood Hits	161
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

PTK6_HUMAN
θ value	0.0736092 (rank : 105)	NC score	0.175768 (rank : 179)
Query Neighborhood Hits	288	Target Neighborhood Hits	1020	Shared Neighborhood Hits	151
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SHAN1_HUMAN
θ value	0.0736092 (rank : 106)	NC score	0.109014 (rank : 251)
Query Neighborhood Hits	288	Target Neighborhood Hits	1041	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CASL_HUMAN
θ value	0.0961366 (rank : 107)	NC score	0.272159 (rank : 111)
Query Neighborhood Hits	288	Target Neighborhood Hits	259	Shared Neighborhood Hits	128
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CIP4_HUMAN
θ value	0.0961366 (rank : 108)	NC score	0.288848 (rank : 103)
Query Neighborhood Hits	288	Target Neighborhood Hits	374	Shared Neighborhood Hits	118
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

EEA1_HUMAN
θ value	0.0961366 (rank : 109)	NC score	0.074270 (rank : 488)
Query Neighborhood Hits	288	Target Neighborhood Hits	1796	Shared Neighborhood Hits	102
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ES8L3_HUMAN
θ value	0.0961366 (rank : 110)	NC score	0.351180 (rank : 54)
Query Neighborhood Hits	288	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HCK_HUMAN
θ value	0.0961366 (rank : 111)	NC score	0.204927 (rank : 142)
Query Neighborhood Hits	288	Target Neighborhood Hits	1035	Shared Neighborhood Hits	159
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	0.0961366 (rank : 112)	NC score	0.202166 (rank : 146)
Query Neighborhood Hits	288	Target Neighborhood Hits	1029	Shared Neighborhood Hits	160
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

M4K4_HUMAN
θ value	0.0961366 (rank : 113)	NC score	0.069602 (rank : 539)
Query Neighborhood Hits	288	Target Neighborhood Hits	1589	Shared Neighborhood Hits	111
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MYO1F_MOUSE
θ value	0.0961366 (rank : 114)	NC score	0.190218 (rank : 162)
Query Neighborhood Hits	288	Target Neighborhood Hits	262	Shared Neighborhood Hits	162
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

OXRP_HUMAN
θ value	0.0961366 (rank : 115)	NC score	0.028241 (rank : 995)
Query Neighborhood Hits	288	Target Neighborhood Hits	544	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

PACN1_HUMAN
θ value	0.0961366 (rank : 116)	NC score	0.384123 (rank : 39)
Query Neighborhood Hits	288	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
θ value	0.0961366 (rank : 117)	NC score	0.393897 (rank : 35)
Query Neighborhood Hits	288	Target Neighborhood Hits	382	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRBS1_MOUSE
θ value	0.0961366 (rank : 118)	NC score	0.396515 (rank : 34)
Query Neighborhood Hits	288	Target Neighborhood Hits	409	Shared Neighborhood Hits	160
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PLCG1_HUMAN
θ value	0.125558 (rank : 119)	NC score	0.321389 (rank : 74)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	0.125558 (rank : 120)	NC score	0.328466 (rank : 66)
Query Neighborhood Hits	288	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB2_HUMAN
θ value	0.125558 (rank : 121)	NC score	0.202579 (rank : 145)
Query Neighborhood Hits	288	Target Neighborhood Hits	263	Shared Neighborhood Hits	106
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SLAP2_MOUSE
θ value	0.125558 (rank : 122)	NC score	0.320950 (rank : 76)
Query Neighborhood Hits	288	Target Neighborhood Hits	136	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SNX9_MOUSE
θ value	0.125558 (rank : 123)	NC score	0.191286 (rank : 160)
Query Neighborhood Hits	288	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TRHY_HUMAN
θ value	0.125558 (rank : 124)	NC score	0.072540 (rank : 506)
Query Neighborhood Hits	288	Target Neighborhood Hits	1385	Shared Neighborhood Hits	99
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

VAV_HUMAN
θ value	0.125558 (rank : 125)	NC score	0.337784 (rank : 60)
Query Neighborhood Hits	288	Target Neighborhood Hits	452	Shared Neighborhood Hits	159
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VINEX_HUMAN
θ value	0.125558 (rank : 126)	NC score	0.418087 (rank : 30)
Query Neighborhood Hits	288	Target Neighborhood Hits	270	Shared Neighborhood Hits	159
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CASL_MOUSE
θ value	0.163984 (rank : 127)	NC score	0.269826 (rank : 115)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

IASPP_MOUSE
θ value	0.163984 (rank : 128)	NC score	0.199715 (rank : 147)
Query Neighborhood Hits	288	Target Neighborhood Hits	1024	Shared Neighborhood Hits	142
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LCK_HUMAN
θ value	0.163984 (rank : 129)	NC score	0.182402 (rank : 167)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	122
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	0.163984 (rank : 130)	NC score	0.180670 (rank : 169)
Query Neighborhood Hits	288	Target Neighborhood Hits	981	Shared Neighborhood Hits	121
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MACOI_HUMAN
θ value	0.163984 (rank : 131)	NC score	0.084666 (rank : 419)
Query Neighborhood Hits	288	Target Neighborhood Hits	650	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

VAV_MOUSE
θ value	0.163984 (rank : 132)	NC score	0.333036 (rank : 63)
Query Neighborhood Hits	288	Target Neighborhood Hits	430	Shared Neighborhood Hits	161
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DNMBP_HUMAN
θ value	0.279714 (rank : 133)	NC score	0.365599 (rank : 49)
Query Neighborhood Hits	288	Target Neighborhood Hits	413	Shared Neighborhood Hits	169
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FYB_HUMAN
θ value	0.279714 (rank : 134)	NC score	0.098663 (rank : 299)
Query Neighborhood Hits	288	Target Neighborhood Hits	379	Shared Neighborhood Hits	34
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GRAP2_MOUSE
θ value	0.279714 (rank : 135)	NC score	0.460392 (rank : 16)
Query Neighborhood Hits	288	Target Neighborhood Hits	297	Shared Neighborhood Hits	166
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HIP1R_MOUSE
θ value	0.279714 (rank : 136)	NC score	0.064619 (rank : 603)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

NEBU_HUMAN
θ value	0.279714 (rank : 137)	NC score	0.247833 (rank : 122)
Query Neighborhood Hits	288	Target Neighborhood Hits	420	Shared Neighborhood Hits	157
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SNX18_HUMAN
θ value	0.279714 (rank : 138)	NC score	0.248018 (rank : 120)
Query Neighborhood Hits	288	Target Neighborhood Hits	207	Shared Neighborhood Hits	112
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SPTA1_MOUSE
θ value	0.279714 (rank : 139)	NC score	0.223926 (rank : 131)
Query Neighborhood Hits	288	Target Neighborhood Hits	675	Shared Neighborhood Hits	184
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

UBP34_HUMAN
θ value	0.279714 (rank : 140)	NC score	0.036929 (rank : 979)
Query Neighborhood Hits	288	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

GRAP2_HUMAN
θ value	0.365318 (rank : 141)	NC score	0.457505 (rank : 18)
Query Neighborhood Hits	288	Target Neighborhood Hits	304	Shared Neighborhood Hits	168
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

HCLS1_MOUSE
θ value	0.365318 (rank : 142)	NC score	0.375650 (rank : 46)
Query Neighborhood Hits	288	Target Neighborhood Hits	329	Shared Neighborhood Hits	139
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MACOI_MOUSE
θ value	0.365318 (rank : 143)	NC score	0.081711 (rank : 445)
Query Neighborhood Hits	288	Target Neighborhood Hits	620	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MATK_HUMAN
θ value	0.365318 (rank : 144)	NC score	0.141296 (rank : 206)
Query Neighborhood Hits	288	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PLCG2_HUMAN
θ value	0.365318 (rank : 145)	NC score	0.324573 (rank : 69)
Query Neighborhood Hits	288	Target Neighborhood Hits	280	Shared Neighborhood Hits	146
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SNX18_MOUSE
θ value	0.365318 (rank : 146)	NC score	0.250647 (rank : 119)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	0.365318 (rank : 147)	NC score	0.196986 (rank : 149)
Query Neighborhood Hits	288	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

UBP34_MOUSE
θ value	0.365318 (rank : 148)	NC score	0.035663 (rank : 980)
Query Neighborhood Hits	288	Target Neighborhood Hits	189	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

VAV3_HUMAN
θ value	0.365318 (rank : 149)	NC score	0.314254 (rank : 78)
Query Neighborhood Hits	288	Target Neighborhood Hits	398	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VINEX_MOUSE
θ value	0.365318 (rank : 150)	NC score	0.415006 (rank : 31)
Query Neighborhood Hits	288	Target Neighborhood Hits	286	Shared Neighborhood Hits	158
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ARHG6_MOUSE
θ value	0.47712 (rank : 151)	NC score	0.313837 (rank : 79)
Query Neighborhood Hits	288	Target Neighborhood Hits	394	Shared Neighborhood Hits	175
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

OSTF1_HUMAN
θ value	0.47712 (rank : 152)	NC score	0.322581 (rank : 72)
Query Neighborhood Hits	288	Target Neighborhood Hits	466	Shared Neighborhood Hits	159
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RUSC1_HUMAN
θ value	0.47712 (rank : 153)	NC score	0.262767 (rank : 117)
Query Neighborhood Hits	288	Target Neighborhood Hits	226	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STAC_MOUSE
θ value	0.47712 (rank : 154)	NC score	0.364515 (rank : 50)
Query Neighborhood Hits	288	Target Neighborhood Hits	268	Shared Neighborhood Hits	146
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG9_MOUSE
θ value	0.62314 (rank : 155)	NC score	0.228720 (rank : 124)
Query Neighborhood Hits	288	Target Neighborhood Hits	234	Shared Neighborhood Hits	132
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CCD19_HUMAN
θ value	0.62314 (rank : 156)	NC score	0.073735 (rank : 494)
Query Neighborhood Hits	288	Target Neighborhood Hits	639	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CE290_HUMAN
θ value	0.62314 (rank : 157)	NC score	0.073503 (rank : 496)
Query Neighborhood Hits	288	Target Neighborhood Hits	1553	Shared Neighborhood Hits	96
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

GCC2_MOUSE
θ value	0.62314 (rank : 158)	NC score	0.069014 (rank : 548)
Query Neighborhood Hits	288	Target Neighborhood Hits	1619	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGB1_HUMAN
θ value	0.62314 (rank : 159)	NC score	0.073289 (rank : 500)
Query Neighborhood Hits	288	Target Neighborhood Hits	2297	Shared Neighborhood Hits	111
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

OSTF1_MOUSE
θ value	0.62314 (rank : 160)	NC score	0.307450 (rank : 83)
Query Neighborhood Hits	288	Target Neighborhood Hits	467	Shared Neighborhood Hits	159
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

VAV3_MOUSE
θ value	0.62314 (rank : 161)	NC score	0.307349 (rank : 84)
Query Neighborhood Hits	288	Target Neighborhood Hits	404	Shared Neighborhood Hits	157
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ADA30_HUMAN
θ value	0.813845 (rank : 162)	NC score	0.009996 (rank : 1011)
Query Neighborhood Hits	288	Target Neighborhood Hits	391	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

CC47_MOUSE
θ value	0.813845 (rank : 163)	NC score	0.042684 (rank : 972)
Query Neighborhood Hits	288	Target Neighborhood Hits	245	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

CCHCR_HUMAN
θ value	0.813845 (rank : 164)	NC score	0.068573 (rank : 556)
Query Neighborhood Hits	288	Target Neighborhood Hits	717	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CP250_HUMAN
θ value	0.813845 (rank : 165)	NC score	0.074449 (rank : 487)
Query Neighborhood Hits	288	Target Neighborhood Hits	1805	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

EEA1_MOUSE
θ value	0.813845 (rank : 166)	NC score	0.070140 (rank : 532)
Query Neighborhood Hits	288	Target Neighborhood Hits	1637	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PACN2_HUMAN
θ value	0.813845 (rank : 167)	NC score	0.385218 (rank : 37)
Query Neighborhood Hits	288	Target Neighborhood Hits	339	Shared Neighborhood Hits	171
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SLAP2_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.312991 (rank : 80)
Query Neighborhood Hits	288	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLY_MOUSE
θ value	0.813845 (rank : 169)	NC score	0.125773 (rank : 224)
Query Neighborhood Hits	288	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

CP250_MOUSE
θ value	1.06291 (rank : 170)	NC score	0.075000 (rank : 484)
Query Neighborhood Hits	288	Target Neighborhood Hits	1583	Shared Neighborhood Hits	98
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

FYB_MOUSE
θ value	1.06291 (rank : 171)	NC score	0.088183 (rank : 395)
Query Neighborhood Hits	288	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

HCLS1_HUMAN
θ value	1.06291 (rank : 172)	NC score	0.372413 (rank : 47)
Query Neighborhood Hits	288	Target Neighborhood Hits	358	Shared Neighborhood Hits	140
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

INVO_HUMAN
θ value	1.06291 (rank : 173)	NC score	0.070343 (rank : 530)
Query Neighborhood Hits	288	Target Neighborhood Hits	636	Shared Neighborhood Hits	58
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

ITK_MOUSE
θ value	1.06291 (rank : 174)	NC score	0.175136 (rank : 180)
Query Neighborhood Hits	288	Target Neighborhood Hits	985	Shared Neighborhood Hits	125
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ARHG7_MOUSE
θ value	1.38821 (rank : 175)	NC score	0.346855 (rank : 56)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	178
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

BSCL2_MOUSE
θ value	1.38821 (rank : 176)	NC score	0.031305 (rank : 988)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

EFS_HUMAN
θ value	1.38821 (rank : 177)	NC score	0.271857 (rank : 113)
Query Neighborhood Hits	288	Target Neighborhood Hits	348	Shared Neighborhood Hits	130
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	1.38821 (rank : 178)	NC score	0.275548 (rank : 108)
Query Neighborhood Hits	288	Target Neighborhood Hits	389	Shared Neighborhood Hits	133
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MATK_MOUSE
θ value	1.38821 (rank : 179)	NC score	0.142334 (rank : 201)
Query Neighborhood Hits	288	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MY18A_MOUSE
θ value	1.38821 (rank : 180)	NC score	0.066274 (rank : 576)
Query Neighborhood Hits	288	Target Neighborhood Hits	1989	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH10_HUMAN
θ value	1.38821 (rank : 181)	NC score	0.070088 (rank : 533)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	108
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	1.38821 (rank : 182)	NC score	0.071274 (rank : 521)
Query Neighborhood Hits	288	Target Neighborhood Hits	1612	Shared Neighborhood Hits	108
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NCOA7_MOUSE
θ value	1.38821 (rank : 183)	NC score	0.031618 (rank : 987)
Query Neighborhood Hits	288	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

OXR1_MOUSE
θ value	1.38821 (rank : 184)	NC score	0.040713 (rank : 974)
Query Neighborhood Hits	288	Target Neighborhood Hits	516	Shared Neighborhood Hits	36
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

PHF14_MOUSE
θ value	1.38821 (rank : 185)	NC score	0.030017 (rank : 991)
Query Neighborhood Hits	288	Target Neighborhood Hits	342	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

RASA1_HUMAN
θ value	1.38821 (rank : 186)	NC score	0.203845 (rank : 144)
Query Neighborhood Hits	288	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SMRC2_HUMAN
θ value	1.38821 (rank : 187)	NC score	0.031738 (rank : 986)
Query Neighborhood Hits	288	Target Neighborhood Hits	499	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

CACB3_HUMAN
θ value	1.81305 (rank : 188)	NC score	0.041038 (rank : 973)
Query Neighborhood Hits	288	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

EI2BE_MOUSE
θ value	1.81305 (rank : 189)	NC score	0.024855 (rank : 997)
Query Neighborhood Hits	288	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHW4, Q3TU39	Gene names	Eif2b5
Domain Architecture	No domain graphic available
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

HNRPC_HUMAN
θ value	1.81305 (rank : 190)	NC score	0.034730 (rank : 981)
Query Neighborhood Hits	288	Target Neighborhood Hits	210	Shared Neighborhood Hits	23
SwissProt Accessions	P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3	Gene names	HNRPC
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

JIP3_HUMAN
θ value	1.81305 (rank : 191)	NC score	0.050563 (rank : 939)
Query Neighborhood Hits	288	Target Neighborhood Hits	1039	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

MYH13_HUMAN
θ value	1.81305 (rank : 192)	NC score	0.069246 (rank : 547)
Query Neighborhood Hits	288	Target Neighborhood Hits	1504	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PHF14_HUMAN
θ value	1.81305 (rank : 193)	NC score	0.033814 (rank : 985)
Query Neighborhood Hits	288	Target Neighborhood Hits	447	Shared Neighborhood Hits	41
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PPIP2_MOUSE
θ value	1.81305 (rank : 194)	NC score	0.132133 (rank : 215)
Query Neighborhood Hits	288	Target Neighborhood Hits	308	Shared Neighborhood Hits	57
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SRMS_HUMAN
θ value	1.81305 (rank : 195)	NC score	0.149259 (rank : 194)
Query Neighborhood Hits	288	Target Neighborhood Hits	946	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

T3JAM_MOUSE
θ value	1.81305 (rank : 196)	NC score	0.053870 (rank : 816)
Query Neighborhood Hits	288	Target Neighborhood Hits	535	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TPR_HUMAN
θ value	1.81305 (rank : 197)	NC score	0.065310 (rank : 593)
Query Neighborhood Hits	288	Target Neighborhood Hits	1921	Shared Neighborhood Hits	102
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

AKAP9_HUMAN
θ value	2.36792 (rank : 198)	NC score	0.069394 (rank : 543)
Query Neighborhood Hits	288	Target Neighborhood Hits	1710	Shared Neighborhood Hits	96
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BRE1B_HUMAN
θ value	2.36792 (rank : 199)	NC score	0.064273 (rank : 607)
Query Neighborhood Hits	288	Target Neighborhood Hits	1040	Shared Neighborhood Hits	71
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	2.36792 (rank : 200)	NC score	0.056477 (rank : 752)
Query Neighborhood Hits	288	Target Neighborhood Hits	970	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CENPE_HUMAN
θ value	2.36792 (rank : 201)	NC score	0.062723 (rank : 635)
Query Neighborhood Hits	288	Target Neighborhood Hits	2060	Shared Neighborhood Hits	107
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CTTB2_HUMAN
θ value	2.36792 (rank : 202)	NC score	0.034727 (rank : 982)
Query Neighborhood Hits	288	Target Neighborhood Hits	1061	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DBNL_HUMAN
θ value	2.36792 (rank : 203)	NC score	0.298444 (rank : 90)
Query Neighborhood Hits	288	Target Neighborhood Hits	244	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	2.36792 (rank : 204)	NC score	0.292942 (rank : 99)
Query Neighborhood Hits	288	Target Neighborhood Hits	306	Shared Neighborhood Hits	133
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DESP_HUMAN
θ value	2.36792 (rank : 205)	NC score	0.065877 (rank : 582)
Query Neighborhood Hits	288	Target Neighborhood Hits	1470	Shared Neighborhood Hits	90
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GOGA4_MOUSE
θ value	2.36792 (rank : 206)	NC score	0.069469 (rank : 542)
Query Neighborhood Hits	288	Target Neighborhood Hits	1939	Shared Neighborhood Hits	105
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

KMHN1_HUMAN
θ value	2.36792 (rank : 207)	NC score	0.060235 (rank : 665)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

OS9_HUMAN
θ value	2.36792 (rank : 208)	NC score	0.034528 (rank : 983)
Query Neighborhood Hits	288	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

SH3G2_HUMAN
θ value	2.36792 (rank : 209)	NC score	0.321243 (rank : 75)
Query Neighborhood Hits	288	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
θ value	2.36792 (rank : 210)	NC score	0.316030 (rank : 77)
Query Neighborhood Hits	288	Target Neighborhood Hits	236	Shared Neighborhood Hits	153
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ARHG4_HUMAN
θ value	3.0926 (rank : 211)	NC score	0.243217 (rank : 123)
Query Neighborhood Hits	288	Target Neighborhood Hits	242	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	3.0926 (rank : 212)	NC score	0.227103 (rank : 125)
Query Neighborhood Hits	288	Target Neighborhood Hits	235	Shared Neighborhood Hits	131
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

BPAEA_MOUSE
θ value	3.0926 (rank : 213)	NC score	0.063709 (rank : 614)
Query Neighborhood Hits	288	Target Neighborhood Hits	1480	Shared Neighborhood Hits	91
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GCC2_HUMAN
θ value	3.0926 (rank : 214)	NC score	0.069007 (rank : 549)
Query Neighborhood Hits	288	Target Neighborhood Hits	1558	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

HNRPC_MOUSE
θ value	3.0926 (rank : 215)	NC score	0.033993 (rank : 984)
Query Neighborhood Hits	288	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z204, Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83	Gene names	Hnrpc, Hnrnpc
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

HXC10_HUMAN
θ value	3.0926 (rank : 216)	NC score	0.003340 (rank : 1015)
Query Neighborhood Hits	288	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

IFT81_MOUSE
θ value	3.0926 (rank : 217)	NC score	0.074865 (rank : 486)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	77
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

JIP3_MOUSE
θ value	3.0926 (rank : 218)	NC score	0.051913 (rank : 887)
Query Neighborhood Hits	288	Target Neighborhood Hits	759	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

LAMA2_HUMAN
θ value	3.0926 (rank : 219)	NC score	0.021282 (rank : 1002)
Query Neighborhood Hits	288	Target Neighborhood Hits	1092	Shared Neighborhood Hits	57
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

NOXO1_HUMAN
θ value	3.0926 (rank : 220)	NC score	0.216158 (rank : 138)
Query Neighborhood Hits	288	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	3.0926 (rank : 221)	NC score	0.271938 (rank : 112)
Query Neighborhood Hits	288	Target Neighborhood Hits	114	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PEG3_MOUSE
θ value	3.0926 (rank : 222)	NC score	-0.003526 (rank : 1017)
Query Neighborhood Hits	288	Target Neighborhood Hits	1101	Shared Neighborhood Hits	14
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

RBP24_HUMAN
θ value	3.0926 (rank : 223)	NC score	0.068915 (rank : 552)
Query Neighborhood Hits	288	Target Neighborhood Hits	1559	Shared Neighborhood Hits	98
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SMRC2_MOUSE
θ value	3.0926 (rank : 224)	NC score	0.029002 (rank : 993)
Query Neighborhood Hits	288	Target Neighborhood Hits	487	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SRMS_MOUSE
θ value	3.0926 (rank : 225)	NC score	0.154699 (rank : 191)
Query Neighborhood Hits	288	Target Neighborhood Hits	964	Shared Neighborhood Hits	104
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ARHG7_HUMAN
θ value	4.03905 (rank : 226)	NC score	0.331900 (rank : 64)
Query Neighborhood Hits	288	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CACB3_MOUSE
θ value	4.03905 (rank : 227)	NC score	0.040546 (rank : 975)
Query Neighborhood Hits	288	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

DMD_MOUSE
θ value	4.03905 (rank : 228)	NC score	0.064513 (rank : 604)
Query Neighborhood Hits	288	Target Neighborhood Hits	1111	Shared Neighborhood Hits	90
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

EM55_HUMAN
θ value	4.03905 (rank : 229)	NC score	0.114093 (rank : 243)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

MRCKB_MOUSE
θ value	4.03905 (rank : 230)	NC score	0.066657 (rank : 574)
Query Neighborhood Hits	288	Target Neighborhood Hits	2180	Shared Neighborhood Hits	137
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NCF4_MOUSE
θ value	4.03905 (rank : 231)	NC score	0.342294 (rank : 58)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	120
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NGEF_MOUSE
θ value	4.03905 (rank : 232)	NC score	0.137188 (rank : 209)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NUP98_HUMAN
θ value	4.03905 (rank : 233)	NC score	0.022382 (rank : 1000)
Query Neighborhood Hits	288	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

REST_HUMAN
θ value	4.03905 (rank : 234)	NC score	0.062304 (rank : 638)
Query Neighborhood Hits	288	Target Neighborhood Hits	1605	Shared Neighborhood Hits	96
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RUSC1_MOUSE
θ value	4.03905 (rank : 235)	NC score	0.218125 (rank : 136)
Query Neighborhood Hits	288	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

APLP1_MOUSE
θ value	5.27518 (rank : 236)	NC score	0.024823 (rank : 998)
Query Neighborhood Hits	288	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

BFSP2_HUMAN
θ value	5.27518 (rank : 237)	NC score	0.018406 (rank : 1005)
Query Neighborhood Hits	288	Target Neighborhood Hits	348	Shared Neighborhood Hits	41
SwissProt Accessions	Q13515, Q9HBW5	Gene names	BFSP2
Domain Architecture
Description	Phakinin (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 49) (CP49) (49 kDa cytoskeletal protein) (CP 47) (CP47) (Lens intermediate filament-like light) (LIFL-L).

CN045_HUMAN
θ value	5.27518 (rank : 238)	NC score	0.044861 (rank : 968)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

CSKP_MOUSE
θ value	5.27518 (rank : 239)	NC score	0.072601 (rank : 503)
Query Neighborhood Hits	288	Target Neighborhood Hits	1027	Shared Neighborhood Hits	119
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DMD_HUMAN
θ value	5.27518 (rank : 240)	NC score	0.063640 (rank : 618)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	90
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

HIP1R_HUMAN
θ value	5.27518 (rank : 241)	NC score	0.061196 (rank : 650)
Query Neighborhood Hits	288	Target Neighborhood Hits	809	Shared Neighborhood Hits	72
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

KIF4A_HUMAN
θ value	5.27518 (rank : 242)	NC score	0.043963 (rank : 971)
Query Neighborhood Hits	288	Target Neighborhood Hits	1159	Shared Neighborhood Hits	80
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MPP4_HUMAN
θ value	5.27518 (rank : 243)	NC score	0.100170 (rank : 281)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	59
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MYRIP_HUMAN
θ value	5.27518 (rank : 244)	NC score	0.018676 (rank : 1004)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

OPTN_HUMAN
θ value	5.27518 (rank : 245)	NC score	0.057723 (rank : 716)
Query Neighborhood Hits	288	Target Neighborhood Hits	827	Shared Neighborhood Hits	72
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

RILP_MOUSE
θ value	5.27518 (rank : 246)	NC score	0.044353 (rank : 970)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RRP5_HUMAN
θ value	5.27518 (rank : 247)	NC score	0.029559 (rank : 992)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

SH3G3_HUMAN
θ value	5.27518 (rank : 248)	NC score	0.297630 (rank : 92)
Query Neighborhood Hits	288	Target Neighborhood Hits	222	Shared Neighborhood Hits	148
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SM1L2_MOUSE
θ value	5.27518 (rank : 249)	NC score	0.069795 (rank : 538)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	78
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SMC1A_HUMAN
θ value	5.27518 (rank : 250)	NC score	0.067212 (rank : 565)
Query Neighborhood Hits	288	Target Neighborhood Hits	1346	Shared Neighborhood Hits	87
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	5.27518 (rank : 251)	NC score	0.067128 (rank : 566)
Query Neighborhood Hits	288	Target Neighborhood Hits	1384	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

TRI22_HUMAN
θ value	5.27518 (rank : 252)	NC score	0.003641 (rank : 1014)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

UBP37_HUMAN
θ value	5.27518 (rank : 253)	NC score	0.012418 (rank : 1008)
Query Neighborhood Hits	288	Target Neighborhood Hits	208	Shared Neighborhood Hits	13
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

ZFY2_MOUSE
θ value	5.27518 (rank : 254)	NC score	-0.007342 (rank : 1018)
Query Neighborhood Hits	288	Target Neighborhood Hits	795	Shared Neighborhood Hits	4
SwissProt Accessions	P20662	Gene names	Zfy2, Zfy-2
Domain Architecture
Description	Zinc finger Y-chromosomal protein 2.

CACB2_HUMAN
θ value	6.88961 (rank : 255)	NC score	0.026928 (rank : 996)
Query Neighborhood Hits	288	Target Neighborhood Hits	99	Shared Neighborhood Hits	18
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

DEN2A_HUMAN
θ value	6.88961 (rank : 256)	NC score	0.008852 (rank : 1012)
Query Neighborhood Hits	288	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

HMMR_HUMAN
θ value	6.88961 (rank : 257)	NC score	0.061337 (rank : 645)
Query Neighborhood Hits	288	Target Neighborhood Hits	1082	Shared Neighborhood Hits	83
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HNRCL_HUMAN
θ value	6.88961 (rank : 258)	NC score	0.037438 (rank : 978)
Query Neighborhood Hits	288	Target Neighborhood Hits	232	Shared Neighborhood Hits	27
SwissProt Accessions	O60812	Gene names	HNRPCL1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP core protein C-like 1).

LEO1_HUMAN
θ value	6.88961 (rank : 259)	NC score	0.015926 (rank : 1006)
Query Neighborhood Hits	288	Target Neighborhood Hits	958	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MAD4_HUMAN
θ value	6.88961 (rank : 260)	NC score	0.012021 (rank : 1009)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	9
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MINK1_HUMAN
θ value	6.88961 (rank : 261)	NC score	0.063701 (rank : 615)
Query Neighborhood Hits	288	Target Neighborhood Hits	1477	Shared Neighborhood Hits	104
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	6.88961 (rank : 262)	NC score	0.063560 (rank : 620)
Query Neighborhood Hits	288	Target Neighborhood Hits	1451	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYH9_HUMAN
θ value	6.88961 (rank : 263)	NC score	0.065566 (rank : 588)
Query Neighborhood Hits	288	Target Neighborhood Hits	1762	Shared Neighborhood Hits	116
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PRP40_HUMAN
θ value	6.88961 (rank : 264)	NC score	0.024618 (rank : 999)
Query Neighborhood Hits	288	Target Neighborhood Hits	442	Shared Neighborhood Hits	42
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

RPGR_HUMAN
θ value	6.88961 (rank : 265)	NC score	0.012900 (rank : 1007)
Query Neighborhood Hits	288	Target Neighborhood Hits	279	Shared Neighborhood Hits	18
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RRBP1_HUMAN
θ value	6.88961 (rank : 266)	NC score	0.054333 (rank : 807)
Query Neighborhood Hits	288	Target Neighborhood Hits	1306	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SEC20_MOUSE
θ value	6.88961 (rank : 267)	NC score	0.050178 (rank : 961)
Query Neighborhood Hits	288	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

SKIL_MOUSE
θ value	6.88961 (rank : 268)	NC score	0.044404 (rank : 969)
Query Neighborhood Hits	288	Target Neighborhood Hits	719	Shared Neighborhood Hits	68
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SMRC1_MOUSE
θ value	6.88961 (rank : 269)	NC score	0.030229 (rank : 990)
Query Neighborhood Hits	288	Target Neighborhood Hits	459	Shared Neighborhood Hits	31
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

TCAL5_HUMAN
θ value	6.88961 (rank : 270)	NC score	0.019172 (rank : 1003)
Query Neighborhood Hits	288	Target Neighborhood Hits	806	Shared Neighborhood Hits	37
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

AKA12_HUMAN
θ value	8.99809 (rank : 271)	NC score	0.030450 (rank : 989)
Query Neighborhood Hits	288	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

AMPH_HUMAN
θ value	8.99809 (rank : 272)	NC score	0.096235 (rank : 329)
Query Neighborhood Hits	288	Target Neighborhood Hits	455	Shared Neighborhood Hits	83
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ARHG4_MOUSE
θ value	8.99809 (rank : 273)	NC score	0.175994 (rank : 178)
Query Neighborhood Hits	288	Target Neighborhood Hits	185	Shared Neighborhood Hits	93
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	8.99809 (rank : 274)	NC score	0.299398 (rank : 88)
Query Neighborhood Hits	288	Target Neighborhood Hits	376	Shared Neighborhood Hits	169
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CA082_HUMAN
θ value	8.99809 (rank : 275)	NC score	0.011946 (rank : 1010)
Query Neighborhood Hits	288	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXW5, Q49AS7, Q9H8Y2	Gene names	C1orf82
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82.

CEP55_MOUSE
θ value	8.99809 (rank : 276)	NC score	0.058944 (rank : 682)
Query Neighborhood Hits	288	Target Neighborhood Hits	693	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CSKP_HUMAN
θ value	8.99809 (rank : 277)	NC score	0.073492 (rank : 497)
Query Neighborhood Hits	288	Target Neighborhood Hits	1022	Shared Neighborhood Hits	114
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

FA50A_MOUSE
θ value	8.99809 (rank : 278)	NC score	0.038153 (rank : 977)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

GOGA1_HUMAN
θ value	8.99809 (rank : 279)	NC score	0.060293 (rank : 664)
Query Neighborhood Hits	288	Target Neighborhood Hits	1222	Shared Neighborhood Hits	85
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

HXC10_MOUSE
θ value	8.99809 (rank : 280)	NC score	0.001520 (rank : 1016)
Query Neighborhood Hits	288	Target Neighborhood Hits	417	Shared Neighborhood Hits	6
SwissProt Accessions	P31257, P31312, Q7TMT7	Gene names	Hoxc10, Hox-3.6, Hoxc-10
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C10 (Hox-3.6).

MORC2_HUMAN
θ value	8.99809 (rank : 281)	NC score	0.028445 (rank : 994)
Query Neighborhood Hits	288	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

MYH6_MOUSE
θ value	8.99809 (rank : 282)	NC score	0.066159 (rank : 580)
Query Neighborhood Hits	288	Target Neighborhood Hits	1501	Shared Neighborhood Hits	102
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

NGEF_HUMAN
θ value	8.99809 (rank : 283)	NC score	0.130687 (rank : 219)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RRBP1_MOUSE
θ value	8.99809 (rank : 284)	NC score	0.057434 (rank : 724)
Query Neighborhood Hits	288	Target Neighborhood Hits	1650	Shared Neighborhood Hits	95
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

SH3G2_MOUSE
θ value	8.99809 (rank : 285)	NC score	0.309149 (rank : 82)
Query Neighborhood Hits	288	Target Neighborhood Hits	319	Shared Neighborhood Hits	166
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SPTN2_HUMAN
θ value	8.99809 (rank : 286)	NC score	0.040370 (rank : 976)
Query Neighborhood Hits	288	Target Neighborhood Hits	535	Shared Neighborhood Hits	51
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

TCEA3_MOUSE
θ value	8.99809 (rank : 287)	NC score	0.007147 (rank : 1013)
Query Neighborhood Hits	288	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P23881, O88710, Q9CTZ8, Q9DCZ5	Gene names	Tcea3, Tfiish
Domain Architecture
Description	Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h).

VIME_HUMAN
θ value	8.99809 (rank : 288)	NC score	0.022130 (rank : 1001)
Query Neighborhood Hits	288	Target Neighborhood Hits	706	Shared Neighborhood Hits	63
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

AAPK1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.050205 (rank : 959)
Query Neighborhood Hits	288	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.099376 (rank : 288)
Query Neighborhood Hits	288	Target Neighborhood Hits	1243	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.102832 (rank : 266)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABR_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.060756 (rank : 656)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	27
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.112611 (rank : 245)
Query Neighborhood Hits	288	Target Neighborhood Hits	1140	Shared Neighborhood Hits	77
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.113289 (rank : 244)
Query Neighborhood Hits	288	Target Neighborhood Hits	1080	Shared Neighborhood Hits	78
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.071393 (rank : 516)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.071370 (rank : 517)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.072591 (rank : 504)
Query Neighborhood Hits	288	Target Neighborhood Hits	709	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.072775 (rank : 502)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.073416 (rank : 498)
Query Neighborhood Hits	288	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.073386 (rank : 499)
Query Neighborhood Hits	288	Target Neighborhood Hits	739	Shared Neighborhood Hits	43
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.067728 (rank : 562)
Query Neighborhood Hits	288	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.068112 (rank : 559)
Query Neighborhood Hits	288	Target Neighborhood Hits	768	Shared Neighborhood Hits	43
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AL2S2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.055229 (rank : 781)
Query Neighborhood Hits	288	Target Neighborhood Hits	727	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.057758 (rank : 714)
Query Neighborhood Hits	288	Target Neighborhood Hits	709	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.053154 (rank : 841)
Query Neighborhood Hits	288	Target Neighborhood Hits	831	Shared Neighborhood Hits	44
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.105774 (rank : 260)
Query Neighborhood Hits	288	Target Neighborhood Hits	795	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.106349 (rank : 257)
Query Neighborhood Hits	288	Target Neighborhood Hits	811	Shared Neighborhood Hits	45
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.065651 (rank : 586)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMPH_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.082130 (rank : 441)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANKK1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.065600 (rank : 587)
Query Neighborhood Hits	288	Target Neighborhood Hits	1075	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.065482 (rank : 589)
Query Neighborhood Hits	288	Target Neighborhood Hits	1072	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.087405 (rank : 404)
Query Neighborhood Hits	288	Target Neighborhood Hits	612	Shared Neighborhood Hits	40
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.087547 (rank : 402)
Query Neighborhood Hits	288	Target Neighborhood Hits	600	Shared Neighborhood Hits	42
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.084277 (rank : 424)
Query Neighborhood Hits	288	Target Neighborhood Hits	646	Shared Neighborhood Hits	42
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.084838 (rank : 417)
Query Neighborhood Hits	288	Target Neighborhood Hits	607	Shared Neighborhood Hits	42
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANR26_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.051471 (rank : 907)
Query Neighborhood Hits	288	Target Neighborhood Hits	1614	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APS_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.138182 (rank : 208)
Query Neighborhood Hits	288	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.109839 (rank : 248)
Query Neighborhood Hits	288	Target Neighborhood Hits	134	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARAF_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.084062 (rank : 431)
Query Neighborhood Hits	288	Target Neighborhood Hits	924	Shared Neighborhood Hits	50
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.084673 (rank : 418)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	49
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.063538 (rank : 623)
Query Neighborhood Hits	288	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.057903 (rank : 711)
Query Neighborhood Hits	288	Target Neighborhood Hits	266	Shared Neighborhood Hits	19
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.054413 (rank : 803)
Query Neighborhood Hits	288	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.054351 (rank : 805)
Query Neighborhood Hits	288	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.080374 (rank : 450)
Query Neighborhood Hits	288	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.079907 (rank : 453)
Query Neighborhood Hits	288	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.110944 (rank : 246)
Query Neighborhood Hits	288	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.076120 (rank : 476)
Query Neighborhood Hits	288	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.077712 (rank : 467)
Query Neighborhood Hits	288	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.072568 (rank : 505)
Query Neighborhood Hits	288	Target Neighborhood Hits	187	Shared Neighborhood Hits	33
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.071910 (rank : 513)
Query Neighborhood Hits	288	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.063437 (rank : 626)
Query Neighborhood Hits	288	Target Neighborhood Hits	375	Shared Neighborhood Hits	34
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.063262 (rank : 629)
Query Neighborhood Hits	288	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.062286 (rank : 640)
Query Neighborhood Hits	288	Target Neighborhood Hits	344	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.058665 (rank : 694)
Query Neighborhood Hits	288	Target Neighborhood Hits	214	Shared Neighborhood Hits	21
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.080105 (rank : 452)
Query Neighborhood Hits	288	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.093157 (rank : 356)
Query Neighborhood Hits	288	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.192346 (rank : 159)
Query Neighborhood Hits	288	Target Neighborhood Hits	956	Shared Neighborhood Hits	170
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.188403 (rank : 164)
Query Neighborhood Hits	288	Target Neighborhood Hits	1244	Shared Neighborhood Hits	179
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.155999 (rank : 189)
Query Neighborhood Hits	288	Target Neighborhood Hits	1156	Shared Neighborhood Hits	173
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AVR2A_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.056619 (rank : 747)
Query Neighborhood Hits	288	Target Neighborhood Hits	767	Shared Neighborhood Hits	44
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.056621 (rank : 745)
Query Neighborhood Hits	288	Target Neighborhood Hits	767	Shared Neighborhood Hits	44
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.057402 (rank : 725)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.057535 (rank : 722)
Query Neighborhood Hits	288	Target Neighborhood Hits	749	Shared Neighborhood Hits	44
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AZI1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.062652 (rank : 636)
Query Neighborhood Hits	288	Target Neighborhood Hits	1000	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

AZI1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.056421 (rank : 753)
Query Neighborhood Hits	288	Target Neighborhood Hits	990	Shared Neighborhood Hits	83
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BAIP2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.059728 (rank : 672)
Query Neighborhood Hits	288	Target Neighborhood Hits	192	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.062294 (rank : 639)
Query Neighborhood Hits	288	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.090064 (rank : 380)
Query Neighborhood Hits	288	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.087612 (rank : 401)
Query Neighborhood Hits	288	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.070998 (rank : 526)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.072104 (rank : 510)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.055557 (rank : 770)
Query Neighborhood Hits	288	Target Neighborhood Hits	197	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BICD1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.051472 (rank : 906)
Query Neighborhood Hits	288	Target Neighborhood Hits	844	Shared Neighborhood Hits	69
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD2_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.051352 (rank : 910)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.051287 (rank : 914)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	73
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BIN1_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.081413 (rank : 446)
Query Neighborhood Hits	288	Target Neighborhood Hits	335	Shared Neighborhood Hits	68
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.084657 (rank : 420)
Query Neighborhood Hits	288	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLNK_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.074214 (rank : 489)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.075880 (rank : 479)
Query Neighborhood Hits	288	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMP2K_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.051243 (rank : 915)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMPR2_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.057094 (rank : 733)
Query Neighborhood Hits	288	Target Neighborhood Hits	736	Shared Neighborhood Hits	44
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.056620 (rank : 746)
Query Neighborhood Hits	288	Target Neighborhood Hits	738	Shared Neighborhood Hits	44
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.078208 (rank : 466)
Query Neighborhood Hits	288	Target Neighborhood Hits	759	Shared Neighborhood Hits	45
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.078388 (rank : 464)
Query Neighborhood Hits	288	Target Neighborhood Hits	758	Shared Neighborhood Hits	44
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.080514 (rank : 449)
Query Neighborhood Hits	288	Target Neighborhood Hits	760	Shared Neighborhood Hits	41
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.080713 (rank : 448)
Query Neighborhood Hits	288	Target Neighborhood Hits	758	Shared Neighborhood Hits	41
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.130930 (rank : 218)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	64
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.131770 (rank : 216)
Query Neighborhood Hits	288	Target Neighborhood Hits	912	Shared Neighborhood Hits	62
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BPA1_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.056862 (rank : 738)
Query Neighborhood Hits	288	Target Neighborhood Hits	1477	Shared Neighborhood Hits	85
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.058087 (rank : 707)
Query Neighborhood Hits	288	Target Neighborhood Hits	1369	Shared Neighborhood Hits	86
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRAF1_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.084136 (rank : 428)
Query Neighborhood Hits	288	Target Neighborhood Hits	883	Shared Neighborhood Hits	50
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRE1A_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.057181 (rank : 730)
Query Neighborhood Hits	288	Target Neighborhood Hits	1071	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.055907 (rank : 762)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	86
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

BRSK1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.050724 (rank : 927)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.052352 (rank : 865)
Query Neighborhood Hits	288	Target Neighborhood Hits	897	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CALD1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.053763 (rank : 821)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	77
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CARD9_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.055614 (rank : 767)
Query Neighborhood Hits	288	Target Neighborhood Hits	602	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CASP_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.056490 (rank : 751)
Query Neighborhood Hits	288	Target Neighborhood Hits	1131	Shared Neighborhood Hits	89
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.058918 (rank : 683)
Query Neighborhood Hits	288	Target Neighborhood Hits	1152	Shared Neighborhood Hits	95
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD11_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.056602 (rank : 748)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	73
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD11_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.050286 (rank : 951)
Query Neighborhood Hits	288	Target Neighborhood Hits	498	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD13_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.056205 (rank : 756)
Query Neighborhood Hits	288	Target Neighborhood Hits	721	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD21_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.055747 (rank : 764)
Query Neighborhood Hits	288	Target Neighborhood Hits	1228	Shared Neighborhood Hits	89
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.053758 (rank : 823)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD27_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.053966 (rank : 813)
Query Neighborhood Hits	288	Target Neighborhood Hits	594	Shared Neighborhood Hits	66
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD27_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.050190 (rank : 960)
Query Neighborhood Hits	288	Target Neighborhood Hits	461	Shared Neighborhood Hits	64
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD39_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.054348 (rank : 806)
Query Neighborhood Hits	288	Target Neighborhood Hits	868	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD39_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.062031 (rank : 642)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.057372 (rank : 726)
Query Neighborhood Hits	288	Target Neighborhood Hits	1139	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD41_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.060512 (rank : 661)
Query Neighborhood Hits	288	Target Neighborhood Hits	1399	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCD46_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.066481 (rank : 575)
Query Neighborhood Hits	288	Target Neighborhood Hits	1430	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD46_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.064959 (rank : 599)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	98
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CCD62_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.050255 (rank : 953)
Query Neighborhood Hits	288	Target Neighborhood Hits	631	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CCD91_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.066949 (rank : 571)
Query Neighborhood Hits	288	Target Neighborhood Hits	868	Shared Neighborhood Hits	74
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CCD91_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.054472 (rank : 802)
Query Neighborhood Hits	288	Target Neighborhood Hits	699	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CCD96_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.059094 (rank : 679)
Query Neighborhood Hits	288	Target Neighborhood Hits	595	Shared Neighborhood Hits	64
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.058700 (rank : 691)
Query Neighborhood Hits	288	Target Neighborhood Hits	704	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.051356 (rank : 909)
Query Neighborhood Hits	288	Target Neighborhood Hits	723	Shared Neighborhood Hits	68
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.060568 (rank : 660)
Query Neighborhood Hits	288	Target Neighborhood Hits	932	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CD2L1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.052664 (rank : 858)
Query Neighborhood Hits	288	Target Neighborhood Hits	1467	Shared Neighborhood Hits	107
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.053633 (rank : 829)
Query Neighborhood Hits	288	Target Neighborhood Hits	1463	Shared Neighborhood Hits	108
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.051331 (rank : 913)
Query Neighborhood Hits	288	Target Neighborhood Hits	1439	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L5_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.052812 (rank : 853)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	50
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.052749 (rank : 856)
Query Neighborhood Hits	288	Target Neighborhood Hits	1011	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.054120 (rank : 812)
Query Neighborhood Hits	288	Target Neighborhood Hits	1275	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDK9_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.050455 (rank : 946)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.050587 (rank : 938)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CE152_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.065443 (rank : 590)
Query Neighborhood Hits	288	Target Neighborhood Hits	976	Shared Neighborhood Hits	79
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CENPF_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.069340 (rank : 545)
Query Neighborhood Hits	288	Target Neighborhood Hits	1932	Shared Neighborhood Hits	110
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CEP63_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.066222 (rank : 578)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	83
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.059254 (rank : 677)
Query Neighborhood Hits	288	Target Neighborhood Hits	1270	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CHIN_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.084096 (rank : 429)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.087198 (rank : 406)
Query Neighborhood Hits	288	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.084088 (rank : 430)
Query Neighborhood Hits	288	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI039_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.058691 (rank : 692)
Query Neighborhood Hits	288	Target Neighborhood Hits	1171	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CI093_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.065816 (rank : 584)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	83
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CI096_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.063540 (rank : 622)
Query Neighborhood Hits	288	Target Neighborhood Hits	821	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CING_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.055580 (rank : 768)
Query Neighborhood Hits	288	Target Neighborhood Hits	1275	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CING_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.062865 (rank : 631)
Query Neighborhood Hits	288	Target Neighborhood Hits	1432	Shared Neighborhood Hits	87
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CISH_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.071919 (rank : 512)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.070476 (rank : 528)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CJ118_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.055131 (rank : 785)
Query Neighborhood Hits	288	Target Neighborhood Hits	1132	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CK5P2_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.055922 (rank : 761)
Query Neighborhood Hits	288	Target Neighborhood Hits	1433	Shared Neighborhood Hits	94
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CK5P2_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.051628 (rank : 900)
Query Neighborhood Hits	288	Target Neighborhood Hits	1151	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CN145_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.055830 (rank : 763)
Query Neighborhood Hits	288	Target Neighborhood Hits	1196	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CN145_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.050618 (rank : 935)
Query Neighborhood Hits	288	Target Neighborhood Hits	916	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNTRB_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.055692 (rank : 766)
Query Neighborhood Hits	288	Target Neighborhood Hits	1029	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.058892 (rank : 685)
Query Neighborhood Hits	288	Target Neighborhood Hits	1290	Shared Neighborhood Hits	85
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP135_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.060894 (rank : 654)
Query Neighborhood Hits	288	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CR034_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.057058 (rank : 736)
Query Neighborhood Hits	288	Target Neighborhood Hits	538	Shared Neighborhood Hits	68
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

CROCC_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.057345 (rank : 727)
Query Neighborhood Hits	288	Target Neighborhood Hits	1409	Shared Neighborhood Hits	92
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CROCC_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.058319 (rank : 702)
Query Neighborhood Hits	288	Target Neighborhood Hits	1460	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CSF1R_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.098486 (rank : 301)
Query Neighborhood Hits	288	Target Neighborhood Hits	943	Shared Neighborhood Hits	44
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.095378 (rank : 337)
Query Neighborhood Hits	288	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CT032_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.257513 (rank : 118)
Query Neighborhood Hits	288	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT2NL_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.054924 (rank : 790)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	79
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.054227 (rank : 809)
Query Neighborhood Hits	288	Target Neighborhood Hits	902	Shared Neighborhood Hits	76
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CTRO_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.064754 (rank : 601)
Query Neighborhood Hits	288	Target Neighborhood Hits	2092	Shared Neighborhood Hits	124
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.066216 (rank : 579)
Query Neighborhood Hits	288	Target Neighborhood Hits	2344	Shared Neighborhood Hits	135
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CUTL1_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.051013 (rank : 922)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	94
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CYLN2_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.058230 (rank : 705)
Query Neighborhood Hits	288	Target Neighborhood Hits	1004	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CYLN2_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.058373 (rank : 700)
Query Neighborhood Hits	288	Target Neighborhood Hits	1002	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CYTSA_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.050085 (rank : 966)
Query Neighborhood Hits	288	Target Neighborhood Hits	1104	Shared Neighborhood Hits	80
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DAPP1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.166690 (rank : 183)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.166122 (rank : 184)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.131241 (rank : 217)
Query Neighborhood Hits	288	Target Neighborhood Hits	592	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.118288 (rank : 237)
Query Neighborhood Hits	288	Target Neighborhood Hits	599	Shared Neighborhood Hits	129
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.118690 (rank : 236)
Query Neighborhood Hits	288	Target Neighborhood Hits	625	Shared Neighborhood Hits	127
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDR1_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.101588 (rank : 272)
Query Neighborhood Hits	288	Target Neighborhood Hits	819	Shared Neighborhood Hits	44
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.102190 (rank : 270)
Query Neighborhood Hits	288	Target Neighborhood Hits	818	Shared Neighborhood Hits	44
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.097117 (rank : 312)
Query Neighborhood Hits	288	Target Neighborhood Hits	818	Shared Neighborhood Hits	46
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.096598 (rank : 322)
Query Neighborhood Hits	288	Target Neighborhood Hits	813	Shared Neighborhood Hits	44
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DLG1_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.068449 (rank : 558)
Query Neighborhood Hits	288	Target Neighborhood Hits	290	Shared Neighborhood Hits	65
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.066101 (rank : 581)
Query Neighborhood Hits	288	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG2_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.069007 (rank : 550)
Query Neighborhood Hits	288	Target Neighborhood Hits	279	Shared Neighborhood Hits	72
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.076307 (rank : 475)
Query Neighborhood Hits	288	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG3_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.063391 (rank : 627)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.062608 (rank : 637)
Query Neighborhood Hits	288	Target Neighborhood Hits	274	Shared Neighborhood Hits	63
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG4_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.068679 (rank : 553)
Query Neighborhood Hits	288	Target Neighborhood Hits	286	Shared Neighborhood Hits	70
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.063687 (rank : 616)
Query Neighborhood Hits	288	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG5_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.074161 (rank : 490)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	103
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DOCK1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.088878 (rank : 388)
Query Neighborhood Hits	288	Target Neighborhood Hits	191	Shared Neighborhood Hits	96
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DUET_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.060071 (rank : 667)
Query Neighborhood Hits	288	Target Neighborhood Hits	1220	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

E2AK1_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.052438 (rank : 864)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.051335 (rank : 911)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	46
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.055492 (rank : 775)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	44
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ECT2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.057876 (rank : 712)
Query Neighborhood Hits	288	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.060612 (rank : 659)
Query Neighborhood Hits	288	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EGFR_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.096162 (rank : 331)
Query Neighborhood Hits	288	Target Neighborhood Hits	939	Shared Neighborhood Hits	46
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.096203 (rank : 330)
Query Neighborhood Hits	288	Target Neighborhood Hits	927	Shared Neighborhood Hits	46
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EM55_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.102193 (rank : 269)
Query Neighborhood Hits	288	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EP15R_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.065162 (rank : 595)
Query Neighborhood Hits	288	Target Neighborhood Hits	1083	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.065414 (rank : 592)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	81
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.063953 (rank : 610)
Query Neighborhood Hits	288	Target Neighborhood Hits	1021	Shared Neighborhood Hits	77
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.065135 (rank : 596)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPHA1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.096242 (rank : 328)
Query Neighborhood Hits	288	Target Neighborhood Hits	997	Shared Neighborhood Hits	45
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.096592 (rank : 323)
Query Neighborhood Hits	288	Target Neighborhood Hits	958	Shared Neighborhood Hits	45
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.095024 (rank : 340)
Query Neighborhood Hits	288	Target Neighborhood Hits	1021	Shared Neighborhood Hits	46
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.095232 (rank : 338)
Query Neighborhood Hits	288	Target Neighborhood Hits	1020	Shared Neighborhood Hits	46
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.092060 (rank : 366)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.092149 (rank : 365)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.093502 (rank : 353)
Query Neighborhood Hits	288	Target Neighborhood Hits	975	Shared Neighborhood Hits	44
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.093458 (rank : 354)
Query Neighborhood Hits	288	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.092893 (rank : 359)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	46
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.096838 (rank : 316)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	44
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.097639 (rank : 307)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.097561 (rank : 308)
Query Neighborhood Hits	288	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.091390 (rank : 371)
Query Neighborhood Hits	288	Target Neighborhood Hits	1053	Shared Neighborhood Hits	46
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.091526 (rank : 369)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	46
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.093828 (rank : 350)
Query Neighborhood Hits	288	Target Neighborhood Hits	956	Shared Neighborhood Hits	44
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.093986 (rank : 348)
Query Neighborhood Hits	288	Target Neighborhood Hits	969	Shared Neighborhood Hits	45
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.100511 (rank : 278)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.092663 (rank : 361)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.093633 (rank : 352)
Query Neighborhood Hits	288	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.093659 (rank : 351)
Query Neighborhood Hits	288	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.094326 (rank : 343)
Query Neighborhood Hits	288	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.094532 (rank : 342)
Query Neighborhood Hits	288	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.094238 (rank : 345)
Query Neighborhood Hits	288	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.093831 (rank : 349)
Query Neighborhood Hits	288	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.100843 (rank : 276)
Query Neighborhood Hits	288	Target Neighborhood Hits	912	Shared Neighborhood Hits	45
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.098779 (rank : 298)
Query Neighborhood Hits	288	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.099787 (rank : 284)
Query Neighborhood Hits	288	Target Neighborhood Hits	1073	Shared Neighborhood Hits	48
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.099715 (rank : 286)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	45
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.099766 (rank : 285)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.099315 (rank : 292)
Query Neighborhood Hits	288	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.099334 (rank : 291)
Query Neighborhood Hits	288	Target Neighborhood Hits	910	Shared Neighborhood Hits	50
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERC2_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.058391 (rank : 699)
Query Neighborhood Hits	288	Target Neighborhood Hits	1156	Shared Neighborhood Hits	86
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.058010 (rank : 710)
Query Neighborhood Hits	288	Target Neighborhood Hits	1166	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

EVPL_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.057729 (rank : 715)
Query Neighborhood Hits	288	Target Neighborhood Hits	895	Shared Neighborhood Hits	77
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.053686 (rank : 826)
Query Neighborhood Hits	288	Target Neighborhood Hits	952	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FAK1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.097212 (rank : 311)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.097222 (rank : 310)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.101814 (rank : 271)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.101450 (rank : 273)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FER_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.136075 (rank : 210)
Query Neighborhood Hits	288	Target Neighborhood Hits	1278	Shared Neighborhood Hits	124
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.110685 (rank : 247)
Query Neighborhood Hits	288	Target Neighborhood Hits	978	Shared Neighborhood Hits	71
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.108113 (rank : 252)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	71
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.051992 (rank : 884)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.051502 (rank : 905)
Query Neighborhood Hits	288	Target Neighborhood Hits	249	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.053331 (rank : 837)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.052013 (rank : 882)
Query Neighborhood Hits	288	Target Neighborhood Hits	219	Shared Neighborhood Hits	31
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.050282 (rank : 952)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGFR1_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.088647 (rank : 392)
Query Neighborhood Hits	288	Target Neighborhood Hits	1069	Shared Neighborhood Hits	44
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.088658 (rank : 391)
Query Neighborhood Hits	288	Target Neighborhood Hits	1068	Shared Neighborhood Hits	44
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.089245 (rank : 384)
Query Neighborhood Hits	288	Target Neighborhood Hits	1062	Shared Neighborhood Hits	44
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.089688 (rank : 382)
Query Neighborhood Hits	288	Target Neighborhood Hits	1062	Shared Neighborhood Hits	44
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.090107 (rank : 379)
Query Neighborhood Hits	288	Target Neighborhood Hits	1042	Shared Neighborhood Hits	44
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.089636 (rank : 383)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	44
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.092253 (rank : 364)
Query Neighborhood Hits	288	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.093993 (rank : 347)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLIP1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.059319 (rank : 676)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	89
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.056739 (rank : 743)
Query Neighborhood Hits	288	Target Neighborhood Hits	1176	Shared Neighborhood Hits	81
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLT3_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.099525 (rank : 287)
Query Neighborhood Hits	288	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.100382 (rank : 279)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	44
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FYCO1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.051675 (rank : 897)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GAS7_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.068544 (rank : 557)
Query Neighborhood Hits	288	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.065419 (rank : 591)
Query Neighborhood Hits	288	Target Neighborhood Hits	259	Shared Neighborhood Hits	43
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS8_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.056373 (rank : 754)
Query Neighborhood Hits	288	Target Neighborhood Hits	819	Shared Neighborhood Hits	67
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GAS8_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.050618 (rank : 934)
Query Neighborhood Hits	288	Target Neighborhood Hits	622	Shared Neighborhood Hits	58
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GOGA1_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.058847 (rank : 686)
Query Neighborhood Hits	288	Target Neighborhood Hits	994	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.056815 (rank : 739)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.059970 (rank : 668)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.059530 (rank : 674)
Query Neighborhood Hits	288	Target Neighborhood Hits	1317	Shared Neighborhood Hits	91
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.064635 (rank : 602)
Query Neighborhood Hits	288	Target Neighborhood Hits	1437	Shared Neighborhood Hits	90
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA4_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.067246 (rank : 564)
Query Neighborhood Hits	288	Target Neighborhood Hits	2034	Shared Neighborhood Hits	114
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GOGA5_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.054541 (rank : 799)
Query Neighborhood Hits	288	Target Neighborhood Hits	1168	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

GOGA5_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.056653 (rank : 744)
Query Neighborhood Hits	288	Target Neighborhood Hits	1434	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGA6_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.056005 (rank : 759)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GRAP1_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.058805 (rank : 688)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	80
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.057069 (rank : 735)
Query Neighborhood Hits	288	Target Neighborhood Hits	1234	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRB10_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.100932 (rank : 275)
Query Neighborhood Hits	288	Target Neighborhood Hits	147	Shared Neighborhood Hits	55
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.102239 (rank : 268)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	54
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.139365 (rank : 207)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.145864 (rank : 198)
Query Neighborhood Hits	288	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.116560 (rank : 239)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.125768 (rank : 225)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GUC2C_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.086997 (rank : 409)
Query Neighborhood Hits	288	Target Neighborhood Hits	624	Shared Neighborhood Hits	40
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.082019 (rank : 443)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.081298 (rank : 447)
Query Neighborhood Hits	288	Target Neighborhood Hits	692	Shared Neighborhood Hits	40
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.091417 (rank : 370)
Query Neighborhood Hits	288	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.084569 (rank : 421)
Query Neighborhood Hits	288	Target Neighborhood Hits	644	Shared Neighborhood Hits	41
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAPIP_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.083123 (rank : 439)
Query Neighborhood Hits	288	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HIP1_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.056536 (rank : 749)
Query Neighborhood Hits	288	Target Neighborhood Hits	1016	Shared Neighborhood Hits	77
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HMMR_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.060814 (rank : 655)
Query Neighborhood Hits	288	Target Neighborhood Hits	1178	Shared Neighborhood Hits	89
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HOOK1_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.050104 (rank : 964)
Query Neighborhood Hits	288	Target Neighborhood Hits	910	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

HOOK3_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.054917 (rank : 791)
Query Neighborhood Hits	288	Target Neighborhood Hits	1070	Shared Neighborhood Hits	85
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.055119 (rank : 786)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

HSH2D_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.141587 (rank : 203)
Query Neighborhood Hits	288	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.087943 (rank : 399)
Query Neighborhood Hits	288	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ICK_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.053947 (rank : 814)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.053805 (rank : 820)
Query Neighborhood Hits	288	Target Neighborhood Hits	860	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IF3A_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.051798 (rank : 891)
Query Neighborhood Hits	288	Target Neighborhood Hits	875	Shared Neighborhood Hits	70
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.053835 (rank : 819)
Query Neighborhood Hits	288	Target Neighborhood Hits	871	Shared Neighborhood Hits	73
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IFT74_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.060394 (rank : 663)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	78
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT74_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.056970 (rank : 737)
Query Neighborhood Hits	288	Target Neighborhood Hits	939	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.063983 (rank : 609)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IGF1R_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.099787 (rank : 283)
Query Neighborhood Hits	288	Target Neighborhood Hits	977	Shared Neighborhood Hits	44
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.099894 (rank : 282)
Query Neighborhood Hits	288	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKKA_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.053182 (rank : 840)
Query Neighborhood Hits	288	Target Neighborhood Hits	863	Shared Neighborhood Hits	49
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.052138 (rank : 874)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	49
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.053761 (rank : 822)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	72
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 583)	NC score	0.053067 (rank : 846)
Query Neighborhood Hits	288	Target Neighborhood Hits	984	Shared Neighborhood Hits	77
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.050740 (rank : 925)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	48
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 585)	NC score	0.052446 (rank : 863)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ILK1_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.091600 (rank : 368)
Query Neighborhood Hits	288	Target Neighborhood Hits	857	Shared Neighborhood Hits	47
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.090607 (rank : 373)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.092297 (rank : 363)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	47
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INCE_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.054786 (rank : 794)
Query Neighborhood Hits	288	Target Neighborhood Hits	978	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.052077 (rank : 877)
Query Neighborhood Hits	288	Target Neighborhood Hits	903	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INSRR_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.099154 (rank : 294)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.098863 (rank : 297)
Query Neighborhood Hits	288	Target Neighborhood Hits	961	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.097339 (rank : 309)
Query Neighborhood Hits	288	Target Neighborhood Hits	963	Shared Neighborhood Hits	45
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.096946 (rank : 314)
Query Neighborhood Hits	288	Target Neighborhood Hits	968	Shared Neighborhood Hits	46
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INVO_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.050108 (rank : 963)
Query Neighborhood Hits	288	Target Neighborhood Hits	474	Shared Neighborhood Hits	50
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK1_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.073915 (rank : 492)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.078505 (rank : 462)
Query Neighborhood Hits	288	Target Neighborhood Hits	784	Shared Neighborhood Hits	42
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.074907 (rank : 485)
Query Neighborhood Hits	288	Target Neighborhood Hits	714	Shared Neighborhood Hits	43
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.079544 (rank : 456)
Query Neighborhood Hits	288	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.085445 (rank : 416)
Query Neighborhood Hits	288	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.075715 (rank : 481)
Query Neighborhood Hits	288	Target Neighborhood Hits	816	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.073032 (rank : 501)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

JAK1_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.087922 (rank : 400)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.088006 (rank : 398)
Query Neighborhood Hits	288	Target Neighborhood Hits	854	Shared Neighborhood Hits	45
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.083668 (rank : 436)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.084018 (rank : 434)
Query Neighborhood Hits	288	Target Neighborhood Hits	839	Shared Neighborhood Hits	45
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.086637 (rank : 410)
Query Neighborhood Hits	288	Target Neighborhood Hits	827	Shared Neighborhood Hits	44
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.083874 (rank : 435)
Query Neighborhood Hits	288	Target Neighborhood Hits	821	Shared Neighborhood Hits	44
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K0555_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.054907 (rank : 792)
Query Neighborhood Hits	288	Target Neighborhood Hits	880	Shared Neighborhood Hits	70
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

KIT_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.095408 (rank : 336)
Query Neighborhood Hits	288	Target Neighborhood Hits	953	Shared Neighborhood Hits	44
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.096499 (rank : 326)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	45
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KMHN1_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.058243 (rank : 704)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	80
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KPCA_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.050594 (rank : 937)
Query Neighborhood Hits	288	Target Neighborhood Hits	1070	Shared Neighborhood Hits	56
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.050936 (rank : 924)
Query Neighborhood Hits	288	Target Neighborhood Hits	1067	Shared Neighborhood Hits	57
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.052268 (rank : 867)
Query Neighborhood Hits	288	Target Neighborhood Hits	1121	Shared Neighborhood Hits	56
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.052658 (rank : 859)
Query Neighborhood Hits	288	Target Neighborhood Hits	1117	Shared Neighborhood Hits	56
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KSR1_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.079343 (rank : 458)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.078212 (rank : 465)
Query Neighborhood Hits	288	Target Neighborhood Hits	870	Shared Neighborhood Hits	45
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.079856 (rank : 454)
Query Neighborhood Hits	288	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.114473 (rank : 242)
Query Neighborhood Hits	288	Target Neighborhood Hits	901	Shared Neighborhood Hits	66
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.115943 (rank : 241)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	67
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KTN1_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.055336 (rank : 779)
Query Neighborhood Hits	288	Target Neighborhood Hits	1197	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

KTN1_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.058716 (rank : 690)
Query Neighborhood Hits	288	Target Neighborhood Hits	1324	Shared Neighborhood Hits	87
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LASP1_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.274275 (rank : 109)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	127
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.271292 (rank : 114)
Query Neighborhood Hits	288	Target Neighborhood Hits	297	Shared Neighborhood Hits	127
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.055259 (rank : 780)
Query Neighborhood Hits	288	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.088282 (rank : 394)
Query Neighborhood Hits	288	Target Neighborhood Hits	531	Shared Neighborhood Hits	49
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.096691 (rank : 318)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIMK1_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.072307 (rank : 509)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	48
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.072443 (rank : 507)
Query Neighborhood Hits	288	Target Neighborhood Hits	1008	Shared Neighborhood Hits	49
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.069477 (rank : 541)
Query Neighborhood Hits	288	Target Neighborhood Hits	986	Shared Neighborhood Hits	48
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.069257 (rank : 546)
Query Neighborhood Hits	288	Target Neighborhood Hits	998	Shared Neighborhood Hits	48
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIPA1_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.053256 (rank : 838)
Query Neighborhood Hits	288	Target Neighborhood Hits	1294	Shared Neighborhood Hits	91
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

LIPA2_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.053632 (rank : 830)
Query Neighborhood Hits	288	Target Neighborhood Hits	1282	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LNK_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.128573 (rank : 220)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.126329 (rank : 223)
Query Neighborhood Hits	288	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC45_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.051133 (rank : 918)
Query Neighborhood Hits	288	Target Neighborhood Hits	933	Shared Neighborhood Hits	71
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.053842 (rank : 818)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF2_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.052037 (rank : 880)
Query Neighborhood Hits	288	Target Neighborhood Hits	791	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.060182 (rank : 666)
Query Neighborhood Hits	288	Target Neighborhood Hits	1237	Shared Neighborhood Hits	47
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.061363 (rank : 644)
Query Neighborhood Hits	288	Target Neighborhood Hits	1267	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.062899 (rank : 630)
Query Neighborhood Hits	288	Target Neighborhood Hits	1382	Shared Neighborhood Hits	48
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.062816 (rank : 634)
Query Neighborhood Hits	288	Target Neighborhood Hits	1359	Shared Neighborhood Hits	48
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.107297 (rank : 254)
Query Neighborhood Hits	288	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.106333 (rank : 258)
Query Neighborhood Hits	288	Target Neighborhood Hits	770	Shared Neighborhood Hits	45
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K11_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.145240 (rank : 199)
Query Neighborhood Hits	288	Target Neighborhood Hits	1136	Shared Neighborhood Hits	155
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 647)	NC score	0.078520 (rank : 461)
Query Neighborhood Hits	288	Target Neighborhood Hits	940	Shared Neighborhood Hits	47
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.078417 (rank : 463)
Query Neighborhood Hits	288	Target Neighborhood Hits	957	Shared Neighborhood Hits	46
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.078578 (rank : 460)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	45
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.051029 (rank : 921)
Query Neighborhood Hits	288	Target Neighborhood Hits	914	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K2_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.050711 (rank : 931)
Query Neighborhood Hits	288	Target Neighborhood Hits	849	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.052257 (rank : 868)
Query Neighborhood Hits	288	Target Neighborhood Hits	885	Shared Neighborhood Hits	48
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.052029 (rank : 881)
Query Neighborhood Hits	288	Target Neighborhood Hits	876	Shared Neighborhood Hits	46
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K7_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.077517 (rank : 469)
Query Neighborhood Hits	288	Target Neighborhood Hits	892	Shared Neighborhood Hits	55
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.077613 (rank : 468)
Query Neighborhood Hits	288	Target Neighborhood Hits	892	Shared Neighborhood Hits	56
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K9_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.141475 (rank : 204)
Query Neighborhood Hits	288	Target Neighborhood Hits	1123	Shared Neighborhood Hits	160
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.152825 (rank : 192)
Query Neighborhood Hits	288	Target Neighborhood Hits	1087	Shared Neighborhood Hits	170
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.050480 (rank : 944)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	44
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K4_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.069570 (rank : 540)
Query Neighborhood Hits	288	Target Neighborhood Hits	1560	Shared Neighborhood Hits	107
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MACF1_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.052224 (rank : 869)
Query Neighborhood Hits	288	Target Neighborhood Hits	1341	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF1_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.052042 (rank : 879)
Query Neighborhood Hits	288	Target Neighborhood Hits	1313	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF4_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.057227 (rank : 729)
Query Neighborhood Hits	288	Target Neighborhood Hits	1321	Shared Neighborhood Hits	80
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MAK_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.053142 (rank : 843)
Query Neighborhood Hits	288	Target Neighborhood Hits	857	Shared Neighborhood Hits	46
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.054220 (rank : 810)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	46
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MARK3_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.050087 (rank : 965)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK4_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.050444 (rank : 948)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	45
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.050455 (rank : 945)
Query Neighborhood Hits	288	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MCF2L_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.100556 (rank : 277)
Query Neighborhood Hits	288	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.071244 (rank : 522)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	35
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MD1L1_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.055514 (rank : 773)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MD1L1_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.056176 (rank : 758)
Query Neighborhood Hits	288	Target Neighborhood Hits	1001	Shared Neighborhood Hits	73
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MERTK_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.098053 (rank : 302)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	41
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.098502 (rank : 300)
Query Neighborhood Hits	288	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.095924 (rank : 332)
Query Neighborhood Hits	288	Target Neighborhood Hits	831	Shared Neighborhood Hits	44
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.096512 (rank : 325)
Query Neighborhood Hits	288	Target Neighborhood Hits	844	Shared Neighborhood Hits	44
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MK04_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.050248 (rank : 954)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	46
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK11_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.050239 (rank : 955)
Query Neighborhood Hits	288	Target Neighborhood Hits	823	Shared Neighborhood Hits	44
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MLKL_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.090468 (rank : 374)
Query Neighborhood Hits	288	Target Neighborhood Hits	600	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.087355 (rank : 405)
Query Neighborhood Hits	288	Target Neighborhood Hits	707	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.084142 (rank : 427)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 681)	NC score	0.084033 (rank : 433)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 682)	NC score	0.082832 (rank : 440)
Query Neighborhood Hits	288	Target Neighborhood Hits	829	Shared Neighborhood Hits	44
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 683)	NC score	0.082021 (rank : 442)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.051763 (rank : 892)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 685)	NC score	0.051923 (rank : 886)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 686)	NC score	0.053655 (rank : 827)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 687)	NC score	0.053913 (rank : 815)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.051568 (rank : 903)
Query Neighborhood Hits	288	Target Neighborhood Hits	825	Shared Neighborhood Hits	44
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 689)	NC score	0.052344 (rank : 866)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.050735 (rank : 926)
Query Neighborhood Hits	288	Target Neighborhood Hits	832	Shared Neighborhood Hits	44
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.050721 (rank : 930)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.052448 (rank : 862)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	44
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.054581 (rank : 797)
Query Neighborhood Hits	288	Target Neighborhood Hits	840	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.052071 (rank : 878)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.051859 (rank : 889)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.054401 (rank : 804)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MPP2_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.097930 (rank : 303)
Query Neighborhood Hits	288	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.097064 (rank : 313)
Query Neighborhood Hits	288	Target Neighborhood Hits	189	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.067067 (rank : 568)
Query Neighborhood Hits	288	Target Neighborhood Hits	171	Shared Neighborhood Hits	33
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.066695 (rank : 573)
Query Neighborhood Hits	288	Target Neighborhood Hits	165	Shared Neighborhood Hits	31
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.098877 (rank : 296)
Query Neighborhood Hits	288	Target Neighborhood Hits	188	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MRCKA_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.061535 (rank : 643)
Query Neighborhood Hits	288	Target Neighborhood Hits	1999	Shared Neighborhood Hits	122
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKB_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.064429 (rank : 606)
Query Neighborhood Hits	288	Target Neighborhood Hits	2239	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MST4_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.058677 (rank : 693)
Query Neighborhood Hits	288	Target Neighborhood Hits	852	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.058575 (rank : 697)
Query Neighborhood Hits	288	Target Neighborhood Hits	860	Shared Neighborhood Hits	45
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.089987 (rank : 381)
Query Neighborhood Hits	288	Target Neighborhood Hits	1074	Shared Neighborhood Hits	44
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.090263 (rank : 377)
Query Neighborhood Hits	288	Target Neighborhood Hits	1057	Shared Neighborhood Hits	44
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MY18A_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.067506 (rank : 563)
Query Neighborhood Hits	288	Target Neighborhood Hits	1929	Shared Neighborhood Hits	116
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18B_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.058988 (rank : 680)
Query Neighborhood Hits	288	Target Neighborhood Hits	1299	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH11_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.067007 (rank : 570)
Query Neighborhood Hits	288	Target Neighborhood Hits	1806	Shared Neighborhood Hits	112
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.065799 (rank : 585)
Query Neighborhood Hits	288	Target Neighborhood Hits	1777	Shared Neighborhood Hits	110
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH14_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.054843 (rank : 793)
Query Neighborhood Hits	288	Target Neighborhood Hits	995	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH14_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.057600 (rank : 719)
Query Neighborhood Hits	288	Target Neighborhood Hits	1225	Shared Neighborhood Hits	86
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH1_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.065876 (rank : 583)
Query Neighborhood Hits	288	Target Neighborhood Hits	1478	Shared Neighborhood Hits	104
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.068679 (rank : 554)
Query Neighborhood Hits	288	Target Neighborhood Hits	1461	Shared Neighborhood Hits	107
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH2_HUMAN
θ value	θ > 10 (rank : 716)	NC score	0.065112 (rank : 597)
Query Neighborhood Hits	288	Target Neighborhood Hits	1491	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.069004 (rank : 551)
Query Neighborhood Hits	288	Target Neighborhood Hits	1660	Shared Neighborhood Hits	112
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH4_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.062864 (rank : 632)
Query Neighborhood Hits	288	Target Neighborhood Hits	1377	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.065244 (rank : 594)
Query Neighborhood Hits	288	Target Neighborhood Hits	1476	Shared Neighborhood Hits	102
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH6_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.062122 (rank : 641)
Query Neighborhood Hits	288	Target Neighborhood Hits	1426	Shared Neighborhood Hits	94
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.064480 (rank : 605)
Query Neighborhood Hits	288	Target Neighborhood Hits	1559	Shared Neighborhood Hits	98
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH8_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.067045 (rank : 569)
Query Neighborhood Hits	288	Target Neighborhood Hits	1610	Shared Neighborhood Hits	105
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.067823 (rank : 561)
Query Neighborhood Hits	288	Target Neighborhood Hits	1600	Shared Neighborhood Hits	105
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.063549 (rank : 621)
Query Neighborhood Hits	288	Target Neighborhood Hits	1829	Shared Neighborhood Hits	110
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYLK2_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.056759 (rank : 742)
Query Neighborhood Hits	288	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYO3A_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.059876 (rank : 671)
Query Neighborhood Hits	288	Target Neighborhood Hits	1033	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.057123 (rank : 732)
Query Neighborhood Hits	288	Target Neighborhood Hits	902	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3B_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.051567 (rank : 904)
Query Neighborhood Hits	288	Target Neighborhood Hits	923	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MYO5A_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.051401 (rank : 908)
Query Neighborhood Hits	288	Target Neighborhood Hits	1092	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5C_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.057602 (rank : 718)
Query Neighborhood Hits	288	Target Neighborhood Hits	1206	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NAF1_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.053519 (rank : 833)
Query Neighborhood Hits	288	Target Neighborhood Hits	937	Shared Neighborhood Hits	71
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NAF1_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.053755 (rank : 824)
Query Neighborhood Hits	288	Target Neighborhood Hits	852	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

NCF4_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.296193 (rank : 94)
Query Neighborhood Hits	288	Target Neighborhood Hits	161	Shared Neighborhood Hits	109
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.281868 (rank : 107)
Query Neighborhood Hits	288	Target Neighborhood Hits	457	Shared Neighborhood Hits	164
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEK11_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.063914 (rank : 611)
Query Neighborhood Hits	288	Target Neighborhood Hits	1043	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.060755 (rank : 657)
Query Neighborhood Hits	288	Target Neighborhood Hits	875	Shared Neighborhood Hits	49
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.054964 (rank : 789)
Query Neighborhood Hits	288	Target Neighborhood Hits	1129	Shared Neighborhood Hits	79
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.055063 (rank : 787)
Query Neighborhood Hits	288	Target Neighborhood Hits	1311	Shared Neighborhood Hits	81
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.051707 (rank : 894)
Query Neighborhood Hits	288	Target Neighborhood Hits	908	Shared Neighborhood Hits	58
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.050233 (rank : 956)
Query Neighborhood Hits	288	Target Neighborhood Hits	876	Shared Neighborhood Hits	49
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.054255 (rank : 808)
Query Neighborhood Hits	288	Target Neighborhood Hits	865	Shared Neighborhood Hits	47
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.052942 (rank : 849)
Query Neighborhood Hits	288	Target Neighborhood Hits	854	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.053561 (rank : 831)
Query Neighborhood Hits	288	Target Neighborhood Hits	883	Shared Neighborhood Hits	45
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.054545 (rank : 798)
Query Neighborhood Hits	288	Target Neighborhood Hits	899	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.055160 (rank : 783)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.055157 (rank : 784)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.055559 (rank : 769)
Query Neighborhood Hits	288	Target Neighborhood Hits	846	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.055475 (rank : 776)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK9_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.050219 (rank : 958)
Query Neighborhood Hits	288	Target Neighborhood Hits	900	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEMO_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.055166 (rank : 782)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEMO_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.053395 (rank : 835)
Query Neighborhood Hits	288	Target Neighborhood Hits	658	Shared Neighborhood Hits	65
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NIM1_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.050618 (rank : 936)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.050543 (rank : 941)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIN_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.058897 (rank : 684)
Query Neighborhood Hits	288	Target Neighborhood Hits	1416	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NIN_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.058843 (rank : 687)
Query Neighborhood Hits	288	Target Neighborhood Hits	1376	Shared Neighborhood Hits	89
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

NTRK1_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.099368 (rank : 289)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.092946 (rank : 358)
Query Neighborhood Hits	288	Target Neighborhood Hits	1081	Shared Neighborhood Hits	44
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.092948 (rank : 357)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	44
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.096745 (rank : 317)
Query Neighborhood Hits	288	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NUAK1_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.051722 (rank : 893)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.051825 (rank : 890)
Query Neighborhood Hits	288	Target Neighborhood Hits	881	Shared Neighborhood Hits	45
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.050618 (rank : 933)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUMA1_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.063608 (rank : 619)
Query Neighborhood Hits	288	Target Neighborhood Hits	1523	Shared Neighborhood Hits	94
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

OFD1_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.051331 (rank : 912)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	66
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

OPTN_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.059352 (rank : 675)
Query Neighborhood Hits	288	Target Neighborhood Hits	1120	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

OXSR1_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.060448 (rank : 662)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.060710 (rank : 658)
Query Neighborhood Hits	288	Target Neighborhood Hits	865	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

P55G_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.162818 (rank : 186)
Query Neighborhood Hits	288	Target Neighborhood Hits	451	Shared Neighborhood Hits	102
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.157520 (rank : 188)
Query Neighborhood Hits	288	Target Neighborhood Hits	401	Shared Neighborhood Hits	98
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.177098 (rank : 175)
Query Neighborhood Hits	288	Target Neighborhood Hits	479	Shared Neighborhood Hits	126
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.181136 (rank : 168)
Query Neighborhood Hits	288	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.170103 (rank : 181)
Query Neighborhood Hits	288	Target Neighborhood Hits	543	Shared Neighborhood Hits	113
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.168619 (rank : 182)
Query Neighborhood Hits	288	Target Neighborhood Hits	519	Shared Neighborhood Hits	114
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCNT_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.064003 (rank : 608)
Query Neighborhood Hits	288	Target Neighborhood Hits	1551	Shared Neighborhood Hits	103
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCNT_MOUSE
θ value	θ > 10 (rank : 775)	NC score	0.052134 (rank : 875)
Query Neighborhood Hits	288	Target Neighborhood Hits	1207	Shared Neighborhood Hits	84
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PEPL_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.056187 (rank : 757)
Query Neighborhood Hits	288	Target Neighborhood Hits	1141	Shared Neighborhood Hits	79
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEPL_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.056495 (rank : 750)
Query Neighborhood Hits	288	Target Neighborhood Hits	1105	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PEX13_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.218929 (rank : 134)
Query Neighborhood Hits	288	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.216099 (rank : 139)
Query Neighborhood Hits	288	Target Neighborhood Hits	126	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PFTK1_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.050139 (rank : 962)
Query Neighborhood Hits	288	Target Neighborhood Hits	834	Shared Neighborhood Hits	45
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.050556 (rank : 940)
Query Neighborhood Hits	288	Target Neighborhood Hits	835	Shared Neighborhood Hits	46
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PGFRA_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.096578 (rank : 324)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	48
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.096672 (rank : 319)
Query Neighborhood Hits	288	Target Neighborhood Hits	975	Shared Neighborhood Hits	44
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.096645 (rank : 321)
Query Neighborhood Hits	288	Target Neighborhood Hits	962	Shared Neighborhood Hits	44
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.096853 (rank : 315)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PIBF1_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.065006 (rank : 598)
Query Neighborhood Hits	288	Target Neighborhood Hits	1041	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PININ_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.051189 (rank : 917)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.077029 (rank : 471)
Query Neighborhood Hits	288	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCB4_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.053221 (rank : 839)
Query Neighborhood Hits	288	Target Neighborhood Hits	658	Shared Neighborhood Hits	64
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLEC1_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.051237 (rank : 916)
Query Neighborhood Hits	288	Target Neighborhood Hits	1326	Shared Neighborhood Hits	84
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.124322 (rank : 227)
Query Neighborhood Hits	288	Target Neighborhood Hits	254	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PREX1_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.073889 (rank : 493)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP4B_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.055533 (rank : 772)
Query Neighborhood Hits	288	Target Neighborhood Hits	1030	Shared Neighborhood Hits	70
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.054994 (rank : 788)
Query Neighborhood Hits	288	Target Neighborhood Hits	1040	Shared Neighborhood Hits	66
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.088173 (rank : 396)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	46
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PTN11_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.103322 (rank : 265)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 797)	NC score	0.103336 (rank : 264)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.086106 (rank : 413)
Query Neighborhood Hits	288	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.087526 (rank : 403)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RABE1_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.060924 (rank : 653)
Query Neighborhood Hits	288	Target Neighborhood Hits	1104	Shared Neighborhood Hits	84
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	θ > 10 (rank : 801)	NC score	0.057072 (rank : 734)
Query Neighborhood Hits	288	Target Neighborhood Hits	1105	Shared Neighborhood Hits	82
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RAD50_HUMAN
θ value	θ > 10 (rank : 802)	NC score	0.061033 (rank : 652)
Query Neighborhood Hits	288	Target Neighborhood Hits	1317	Shared Neighborhood Hits	83
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 803)	NC score	0.061235 (rank : 649)
Query Neighborhood Hits	288	Target Neighborhood Hits	1366	Shared Neighborhood Hits	85
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RAF1_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.084532 (rank : 422)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.084049 (rank : 432)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RB6I2_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.058067 (rank : 709)
Query Neighborhood Hits	288	Target Neighborhood Hits	1584	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	θ > 10 (rank : 807)	NC score	0.057832 (rank : 713)
Query Neighborhood Hits	288	Target Neighborhood Hits	1433	Shared Neighborhood Hits	91
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBCC1_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.055382 (rank : 778)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RBCC1_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.054198 (rank : 811)
Query Neighborhood Hits	288	Target Neighborhood Hits	1048	Shared Neighborhood Hits	77
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RBP1_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.051111 (rank : 920)
Query Neighborhood Hits	288	Target Neighborhood Hits	521	Shared Neighborhood Hits	55
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.050447 (rank : 947)
Query Neighborhood Hits	288	Target Neighborhood Hits	493	Shared Neighborhood Hits	50
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

REST_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.059201 (rank : 678)
Query Neighborhood Hits	288	Target Neighborhood Hits	1506	Shared Neighborhood Hits	92
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RET_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.095924 (rank : 333)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	44
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.095092 (rank : 339)
Query Neighborhood Hits	288	Target Neighborhood Hits	884	Shared Neighborhood Hits	44
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RFIP3_HUMAN
θ value	θ > 10 (rank : 815)	NC score	0.052587 (rank : 860)
Query Neighborhood Hits	288	Target Neighborhood Hits	1055	Shared Neighborhood Hits	76
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RGNEF_MOUSE
θ value	θ > 10 (rank : 816)	NC score	0.068661 (rank : 555)
Query Neighborhood Hits	288	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.070075 (rank : 534)
Query Neighborhood Hits	288	Target Neighborhood Hits	186	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.076479 (rank : 474)
Query Neighborhood Hits	288	Target Neighborhood Hits	190	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 819)	NC score	0.079821 (rank : 455)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.050648 (rank : 932)
Query Neighborhood Hits	288	Target Neighborhood Hits	550	Shared Neighborhood Hits	57
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG26_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.158367 (rank : 187)
Query Neighborhood Hits	288	Target Neighborhood Hits	281	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 822)	NC score	0.142897 (rank : 200)
Query Neighborhood Hits	288	Target Neighborhood Hits	1479	Shared Neighborhood Hits	180
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 823)	NC score	0.148546 (rank : 195)
Query Neighborhood Hits	288	Target Neighborhood Hits	1376	Shared Neighborhood Hits	195
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_MOUSE
θ value	θ > 10 (rank : 824)	NC score	0.190927 (rank : 161)
Query Neighborhood Hits	288	Target Neighborhood Hits	246	Shared Neighborhood Hits	106
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIPK1_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.079519 (rank : 457)
Query Neighborhood Hits	288	Target Neighborhood Hits	891	Shared Neighborhood Hits	45
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.080197 (rank : 451)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	45
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 827)	NC score	0.076058 (rank : 477)
Query Neighborhood Hits	288	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.076688 (rank : 473)
Query Neighborhood Hits	288	Target Neighborhood Hits	776	Shared Neighborhood Hits	44
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.075548 (rank : 482)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.076744 (rank : 472)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.063648 (rank : 617)
Query Neighborhood Hits	288	Target Neighborhood Hits	1094	Shared Neighborhood Hits	49
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.070293 (rank : 531)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.070349 (rank : 529)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ROCK1_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.059905 (rank : 670)
Query Neighborhood Hits	288	Target Neighborhood Hits	2000	Shared Neighborhood Hits	123
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.061317 (rank : 646)
Query Neighborhood Hits	288	Target Neighborhood Hits	2126	Shared Neighborhood Hits	128
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK2_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.058978 (rank : 681)
Query Neighborhood Hits	288	Target Neighborhood Hits	2073	Shared Neighborhood Hits	121
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.059675 (rank : 673)
Query Neighborhood Hits	288	Target Neighborhood Hits	2072	Shared Neighborhood Hits	122
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RON_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.097912 (rank : 304)
Query Neighborhood Hits	288	Target Neighborhood Hits	842	Shared Neighborhood Hits	44
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.099282 (rank : 293)
Query Neighborhood Hits	288	Target Neighborhood Hits	836	Shared Neighborhood Hits	44
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.094210 (rank : 346)
Query Neighborhood Hits	288	Target Neighborhood Hits	1018	Shared Neighborhood Hits	44
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 841)	NC score	0.094638 (rank : 341)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.095626 (rank : 335)
Query Neighborhood Hits	288	Target Neighborhood Hits	1014	Shared Neighborhood Hits	45
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 843)	NC score	0.097662 (rank : 306)
Query Neighborhood Hits	288	Target Neighborhood Hits	1000	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.104298 (rank : 262)
Query Neighborhood Hits	288	Target Neighborhood Hits	907	Shared Neighborhood Hits	45
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RPGR1_MOUSE
θ value	θ > 10 (rank : 845)	NC score	0.054735 (rank : 795)
Query Neighborhood Hits	288	Target Neighborhood Hits	713	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RUFY2_HUMAN
θ value	θ > 10 (rank : 846)	NC score	0.052816 (rank : 852)
Query Neighborhood Hits	288	Target Neighborhood Hits	1208	Shared Neighborhood Hits	83
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUSC2_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.098987 (rank : 295)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.073603 (rank : 495)
Query Neighborhood Hits	288	Target Neighborhood Hits	305	Shared Neighborhood Hits	59
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RYK_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.106895 (rank : 256)
Query Neighborhood Hits	288	Target Neighborhood Hits	701	Shared Neighborhood Hits	41
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 850)	NC score	0.105988 (rank : 259)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAMN1_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.058279 (rank : 703)
Query Neighborhood Hits	288	Target Neighborhood Hits	74	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.052512 (rank : 861)
Query Neighborhood Hits	288	Target Neighborhood Hits	69	Shared Neighborhood Hits	35
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.063770 (rank : 613)
Query Neighborhood Hits	288	Target Neighborhood Hits	292	Shared Neighborhood Hits	50
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.061262 (rank : 648)
Query Neighborhood Hits	288	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SBK1_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.052719 (rank : 857)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.053394 (rank : 836)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SDCG8_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.058770 (rank : 689)
Query Neighborhood Hits	288	Target Neighborhood Hits	1002	Shared Neighborhood Hits	75
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SDCG8_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.050524 (rank : 943)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	71
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SH21A_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.155831 (rank : 190)
Query Neighborhood Hits	288	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.163132 (rank : 185)
Query Neighborhood Hits	288	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.179722 (rank : 171)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 862)	NC score	0.193526 (rank : 157)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 863)	NC score	0.086410 (rank : 411)
Query Neighborhood Hits	288	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.096663 (rank : 320)
Query Neighborhood Hits	288	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.083244 (rank : 438)
Query Neighborhood Hits	288	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.124009 (rank : 228)
Query Neighborhood Hits	288	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.088505 (rank : 393)
Query Neighborhood Hits	288	Target Neighborhood Hits	326	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.104256 (rank : 263)
Query Neighborhood Hits	288	Target Neighborhood Hits	188	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 869)	NC score	0.107215 (rank : 255)
Query Neighborhood Hits	288	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G1_HUMAN
θ value	θ > 10 (rank : 870)	NC score	0.287241 (rank : 104)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 871)	NC score	0.289541 (rank : 102)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	167
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SHAN2_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.116258 (rank : 240)
Query Neighborhood Hits	288	Target Neighborhood Hits	446	Shared Neighborhood Hits	92
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.132511 (rank : 214)
Query Neighborhood Hits	288	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.136003 (rank : 211)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.134102 (rank : 212)
Query Neighborhood Hits	288	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 876)	NC score	0.132777 (rank : 213)
Query Neighborhood Hits	288	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 877)	NC score	0.126835 (rank : 222)
Query Neighborhood Hits	288	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 878)	NC score	0.124409 (rank : 226)
Query Neighborhood Hits	288	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.119068 (rank : 234)
Query Neighborhood Hits	288	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.128486 (rank : 221)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.123660 (rank : 230)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 882)	NC score	0.123767 (rank : 229)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 883)	NC score	0.142333 (rank : 202)
Query Neighborhood Hits	288	Target Neighborhood Hits	164	Shared Neighborhood Hits	55
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.148293 (rank : 196)
Query Neighborhood Hits	288	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.094261 (rank : 344)
Query Neighborhood Hits	288	Target Neighborhood Hits	96	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.097713 (rank : 305)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.089109 (rank : 386)
Query Neighborhood Hits	288	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 888)	NC score	0.091664 (rank : 367)
Query Neighborhood Hits	288	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.273390 (rank : 110)
Query Neighborhood Hits	288	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.269780 (rank : 116)
Query Neighborhood Hits	288	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLK_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.063517 (rank : 624)
Query Neighborhood Hits	288	Target Neighborhood Hits	1775	Shared Neighborhood Hits	118
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.062846 (rank : 633)
Query Neighborhood Hits	288	Target Neighborhood Hits	1798	Shared Neighborhood Hits	123
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SLY_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.089054 (rank : 387)
Query Neighborhood Hits	288	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SMC2_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.057149 (rank : 731)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	93
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SMC2_MOUSE
θ value	θ > 10 (rank : 895)	NC score	0.051681 (rank : 896)
Query Neighborhood Hits	288	Target Neighborhood Hits	1131	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC3_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.058081 (rank : 708)
Query Neighborhood Hits	288	Target Neighborhood Hits	1186	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	θ > 10 (rank : 897)	NC score	0.058329 (rank : 701)
Query Neighborhood Hits	288	Target Neighborhood Hits	1187	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC4_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.055936 (rank : 760)
Query Neighborhood Hits	288	Target Neighborhood Hits	937	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SMC4_MOUSE
θ value	θ > 10 (rank : 899)	NC score	0.051128 (rank : 919)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SN1L1_HUMAN
θ value	θ > 10 (rank : 900)	NC score	0.050535 (rank : 942)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	44
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.051654 (rank : 899)
Query Neighborhood Hits	288	Target Neighborhood Hits	895	Shared Neighborhood Hits	47
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.053083 (rank : 845)
Query Neighborhood Hits	288	Target Neighborhood Hits	964	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 903)	NC score	0.052841 (rank : 851)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SOCS2_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.067091 (rank : 567)
Query Neighborhood Hits	288	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 905)	NC score	0.074084 (rank : 491)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS3_HUMAN
θ value	θ > 10 (rank : 906)	NC score	0.053485 (rank : 834)
Query Neighborhood Hits	288	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	θ > 10 (rank : 907)	NC score	0.050723 (rank : 928)
Query Neighborhood Hits	288	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS6_HUMAN
θ value	θ > 10 (rank : 908)	NC score	0.075109 (rank : 483)
Query Neighborhood Hits	288	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 909)	NC score	0.075781 (rank : 480)
Query Neighborhood Hits	288	Target Neighborhood Hits	146	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.102826 (rank : 267)
Query Neighborhood Hits	288	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPTB2_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.055536 (rank : 771)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	65
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.057540 (rank : 721)
Query Neighborhood Hits	288	Target Neighborhood Hits	770	Shared Neighborhood Hits	69
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

STAC3_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.330679 (rank : 65)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	134
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 914)	NC score	0.325234 (rank : 68)
Query Neighborhood Hits	288	Target Neighborhood Hits	232	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STK10_HUMAN
θ value	θ > 10 (rank : 915)	NC score	0.066916 (rank : 572)
Query Neighborhood Hits	288	Target Neighborhood Hits	1921	Shared Neighborhood Hits	116
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 916)	NC score	0.069373 (rank : 544)
Query Neighborhood Hits	288	Target Neighborhood Hits	2132	Shared Neighborhood Hits	131
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK16_HUMAN
θ value	θ > 10 (rank : 917)	NC score	0.053867 (rank : 817)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 918)	NC score	0.055413 (rank : 777)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 919)	NC score	0.058090 (rank : 706)
Query Neighborhood Hits	288	Target Neighborhood Hits	853	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 920)	NC score	0.058590 (rank : 696)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	44
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 921)	NC score	0.057254 (rank : 728)
Query Neighborhood Hits	288	Target Neighborhood Hits	853	Shared Neighborhood Hits	44
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 922)	NC score	0.057504 (rank : 723)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK39_HUMAN
θ value	θ > 10 (rank : 923)	NC score	0.061291 (rank : 647)
Query Neighborhood Hits	288	Target Neighborhood Hits	882	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 924)	NC score	0.061149 (rank : 651)
Query Neighborhood Hits	288	Target Neighborhood Hits	915	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.052193 (rank : 871)
Query Neighborhood Hits	288	Target Neighborhood Hits	861	Shared Neighborhood Hits	47
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 926)	NC score	0.052107 (rank : 876)
Query Neighborhood Hits	288	Target Neighborhood Hits	869	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 927)	NC score	0.052218 (rank : 870)
Query Neighborhood Hits	288	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 928)	NC score	0.052146 (rank : 873)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STS1_HUMAN
θ value	θ > 10 (rank : 929)	NC score	0.084156 (rank : 426)
Query Neighborhood Hits	288	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 930)	NC score	0.081843 (rank : 444)
Query Neighborhood Hits	288	Target Neighborhood Hits	104	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.088106 (rank : 397)
Query Neighborhood Hits	288	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STYK1_HUMAN
θ value	θ > 10 (rank : 932)	NC score	0.109281 (rank : 249)
Query Neighborhood Hits	288	Target Neighborhood Hits	786	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 933)	NC score	0.108054 (rank : 253)
Query Neighborhood Hits	288	Target Neighborhood Hits	779	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SWP70_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.051926 (rank : 885)
Query Neighborhood Hits	288	Target Neighborhood Hits	973	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 935)	NC score	0.051613 (rank : 901)
Query Neighborhood Hits	288	Target Neighborhood Hits	1097	Shared Neighborhood Hits	81
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_HUMAN
θ value	θ > 10 (rank : 936)	NC score	0.057588 (rank : 720)
Query Neighborhood Hits	288	Target Neighborhood Hits	1313	Shared Neighborhood Hits	83
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYCP1_MOUSE
θ value	θ > 10 (rank : 937)	NC score	0.056771 (rank : 741)
Query Neighborhood Hits	288	Target Neighborhood Hits	1456	Shared Neighborhood Hits	93
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE1_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.059930 (rank : 669)
Query Neighborhood Hits	288	Target Neighborhood Hits	1484	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYNE2_HUMAN
θ value	θ > 10 (rank : 939)	NC score	0.053543 (rank : 832)
Query Neighborhood Hits	288	Target Neighborhood Hits	1323	Shared Neighborhood Hits	84
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T3JAM_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.051583 (rank : 902)
Query Neighborhood Hits	288	Target Neighborhood Hits	533	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TAOK1_HUMAN
θ value	θ > 10 (rank : 941)	NC score	0.071280 (rank : 519)
Query Neighborhood Hits	288	Target Neighborhood Hits	1734	Shared Neighborhood Hits	112
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 942)	NC score	0.071276 (rank : 520)
Query Neighborhood Hits	288	Target Neighborhood Hits	1720	Shared Neighborhood Hits	113
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 943)	NC score	0.063277 (rank : 628)
Query Neighborhood Hits	288	Target Neighborhood Hits	1172	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 944)	NC score	0.069944 (rank : 535)
Query Neighborhood Hits	288	Target Neighborhood Hits	1373	Shared Neighborhood Hits	109
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 945)	NC score	0.068064 (rank : 560)
Query Neighborhood Hits	288	Target Neighborhood Hits	1494	Shared Neighborhood Hits	105
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 946)	NC score	0.066251 (rank : 577)
Query Neighborhood Hits	288	Target Neighborhood Hits	1458	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAXB1_HUMAN
θ value	θ > 10 (rank : 947)	NC score	0.058561 (rank : 698)
Query Neighborhood Hits	288	Target Neighborhood Hits	829	Shared Neighborhood Hits	73
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TAXB1_MOUSE
θ value	θ > 10 (rank : 948)	NC score	0.056299 (rank : 755)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	76
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TBK1_HUMAN
θ value	θ > 10 (rank : 949)	NC score	0.050366 (rank : 950)
Query Neighborhood Hits	288	Target Neighborhood Hits	861	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 950)	NC score	0.050722 (rank : 929)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TCGAP_HUMAN
θ value	θ > 10 (rank : 951)	NC score	0.109201 (rank : 250)
Query Neighborhood Hits	288	Target Neighborhood Hits	872	Shared Neighborhood Hits	105
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 952)	NC score	0.122101 (rank : 231)
Query Neighborhood Hits	288	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCRG1_HUMAN
θ value	θ > 10 (rank : 953)	NC score	0.052158 (rank : 872)
Query Neighborhood Hits	288	Target Neighborhood Hits	929	Shared Neighborhood Hits	63
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 954)	NC score	0.052000 (rank : 883)
Query Neighborhood Hits	288	Target Neighborhood Hits	947	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TENS4_HUMAN
θ value	θ > 10 (rank : 955)	NC score	0.071167 (rank : 523)
Query Neighborhood Hits	288	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 956)	NC score	0.079307 (rank : 459)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TESK1_HUMAN
θ value	θ > 10 (rank : 957)	NC score	0.069808 (rank : 537)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 958)	NC score	0.069841 (rank : 536)
Query Neighborhood Hits	288	Target Neighborhood Hits	862	Shared Neighborhood Hits	44
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 959)	NC score	0.072313 (rank : 508)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	45
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 960)	NC score	0.071444 (rank : 515)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 961)	NC score	0.101392 (rank : 274)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 962)	NC score	0.104353 (rank : 261)
Query Neighborhood Hits	288	Target Neighborhood Hits	1333	Shared Neighborhood Hits	92
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 963)	NC score	0.071954 (rank : 511)
Query Neighborhood Hits	288	Target Neighborhood Hits	755	Shared Neighborhood Hits	44
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 964)	NC score	0.071862 (rank : 514)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 965)	NC score	0.052810 (rank : 854)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 966)	NC score	0.052890 (rank : 850)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIAM1_HUMAN
θ value	θ > 10 (rank : 967)	NC score	0.075930 (rank : 478)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 968)	NC score	0.077129 (rank : 470)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE1_HUMAN
θ value	θ > 10 (rank : 969)	NC score	0.090675 (rank : 372)
Query Neighborhood Hits	288	Target Neighborhood Hits	1241	Shared Neighborhood Hits	45
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 970)	NC score	0.090435 (rank : 375)
Query Neighborhood Hits	288	Target Neighborhood Hits	1266	Shared Neighborhood Hits	46
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 971)	NC score	0.090329 (rank : 376)
Query Neighborhood Hits	288	Target Neighborhood Hits	1192	Shared Neighborhood Hits	46
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 972)	NC score	0.090206 (rank : 378)
Query Neighborhood Hits	288	Target Neighborhood Hits	1204	Shared Neighborhood Hits	46
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TLK2_HUMAN
θ value	θ > 10 (rank : 973)	NC score	0.051670 (rank : 898)
Query Neighborhood Hits	288	Target Neighborhood Hits	1044	Shared Neighborhood Hits	77
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 974)	NC score	0.051911 (rank : 888)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	82
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TMF1_HUMAN
θ value	θ > 10 (rank : 975)	NC score	0.053718 (rank : 825)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	76
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TNI3K_HUMAN
θ value	θ > 10 (rank : 976)	NC score	0.070827 (rank : 527)
Query Neighborhood Hits	288	Target Neighborhood Hits	1084	Shared Neighborhood Hits	49
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 977)	NC score	0.071067 (rank : 525)
Query Neighborhood Hits	288	Target Neighborhood Hits	1079	Shared Neighborhood Hits	49
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 978)	NC score	0.063825 (rank : 612)
Query Neighborhood Hits	288	Target Neighborhood Hits	1570	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 979)	NC score	0.100217 (rank : 280)
Query Neighborhood Hits	288	Target Neighborhood Hits	815	Shared Neighborhood Hits	46
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 980)	NC score	0.099358 (rank : 290)
Query Neighborhood Hits	288	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 981)	NC score	0.071103 (rank : 524)
Query Neighborhood Hits	288	Target Neighborhood Hits	605	Shared Neighborhood Hits	42
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 982)	NC score	0.071314 (rank : 518)
Query Neighborhood Hits	288	Target Neighborhood Hits	618	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRIPB_HUMAN
θ value	θ > 10 (rank : 983)	NC score	0.063449 (rank : 625)
Query Neighborhood Hits	288	Target Neighborhood Hits	1587	Shared Neighborhood Hits	98
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TSSK4_HUMAN
θ value	θ > 10 (rank : 984)	NC score	0.051695 (rank : 895)
Query Neighborhood Hits	288	Target Neighborhood Hits	836	Shared Neighborhood Hits	44
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 985)	NC score	0.050948 (rank : 923)
Query Neighborhood Hits	288	Target Neighborhood Hits	840	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TTBK1_HUMAN
θ value	θ > 10 (rank : 986)	NC score	0.064821 (rank : 600)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	60
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 987)	NC score	0.057706 (rank : 717)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 988)	NC score	0.058616 (rank : 695)
Query Neighborhood Hits	288	Target Neighborhood Hits	811	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TUFT1_HUMAN
θ value	θ > 10 (rank : 989)	NC score	0.053647 (rank : 828)
Query Neighborhood Hits	288	Target Neighborhood Hits	686	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TUFT1_MOUSE
θ value	θ > 10 (rank : 990)	NC score	0.053046 (rank : 847)
Query Neighborhood Hits	288	Target Neighborhood Hits	732	Shared Neighborhood Hits	67
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

TYK2_HUMAN
θ value	θ > 10 (rank : 991)	NC score	0.086038 (rank : 414)
Query Neighborhood Hits	288	Target Neighborhood Hits	841	Shared Neighborhood Hits	44
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 992)	NC score	0.087163 (rank : 407)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 993)	NC score	0.092750 (rank : 360)
Query Neighborhood Hits	288	Target Neighborhood Hits	995	Shared Neighborhood Hits	43
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 994)	NC score	0.093312 (rank : 355)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UACA_MOUSE
θ value	θ > 10 (rank : 995)	NC score	0.050226 (rank : 957)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

UFO_HUMAN
θ value	θ > 10 (rank : 996)	NC score	0.096377 (rank : 327)
Query Neighborhood Hits	288	Target Neighborhood Hits	981	Shared Neighborhood Hits	44
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 997)	NC score	0.095778 (rank : 334)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ULK1_HUMAN
θ value	θ > 10 (rank : 998)	NC score	0.053032 (rank : 848)
Query Neighborhood Hits	288	Target Neighborhood Hits	1121	Shared Neighborhood Hits	51
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 999)	NC score	0.054731 (rank : 796)
Query Neighborhood Hits	288	Target Neighborhood Hits	1214	Shared Neighborhood Hits	55
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1000)	NC score	0.052767 (rank : 855)
Query Neighborhood Hits	288	Target Neighborhood Hits	979	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1001)	NC score	0.053105 (rank : 844)
Query Neighborhood Hits	288	Target Neighborhood Hits	943	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

UTRO_HUMAN
θ value	θ > 10 (rank : 1002)	NC score	0.053146 (rank : 842)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	68
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

VAV2_HUMAN
θ value	θ > 10 (rank : 1003)	NC score	0.298739 (rank : 89)
Query Neighborhood Hits	288	Target Neighborhood Hits	453	Shared Neighborhood Hits	163
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1004)	NC score	0.298443 (rank : 91)
Query Neighborhood Hits	288	Target Neighborhood Hits	456	Shared Neighborhood Hits	164
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VGFR1_HUMAN
θ value	θ > 10 (rank : 1005)	NC score	0.084528 (rank : 423)
Query Neighborhood Hits	288	Target Neighborhood Hits	1109	Shared Neighborhood Hits	44
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 1006)	NC score	0.084211 (rank : 425)
Query Neighborhood Hits	288	Target Neighborhood Hits	1118	Shared Neighborhood Hits	44
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1007)	NC score	0.085930 (rank : 415)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	44
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1008)	NC score	0.086240 (rank : 412)
Query Neighborhood Hits	288	Target Neighborhood Hits	1089	Shared Neighborhood Hits	44
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1009)	NC score	0.088799 (rank : 390)
Query Neighborhood Hits	288	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1010)	NC score	0.089224 (rank : 385)
Query Neighborhood Hits	288	Target Neighborhood Hits	1056	Shared Neighborhood Hits	44
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WNK1_HUMAN
θ value	θ > 10 (rank : 1011)	NC score	0.054522 (rank : 800)
Query Neighborhood Hits	288	Target Neighborhood Hits	1158	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 1012)	NC score	0.054485 (rank : 801)
Query Neighborhood Hits	288	Target Neighborhood Hits	1179	Shared Neighborhood Hits	53
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 1013)	NC score	0.055507 (rank : 774)
Query Neighborhood Hits	288	Target Neighborhood Hits	1407	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	θ > 10 (rank : 1014)	NC score	0.055740 (rank : 765)
Query Neighborhood Hits	288	Target Neighborhood Hits	948	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

XE7_HUMAN
θ value	θ > 10 (rank : 1015)	NC score	0.050376 (rank : 949)
Query Neighborhood Hits	288	Target Neighborhood Hits	738	Shared Neighborhood Hits	71
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

YSK4_HUMAN
θ value	θ > 10 (rank : 1016)	NC score	0.056796 (rank : 740)
Query Neighborhood Hits	288	Target Neighborhood Hits	921	Shared Neighborhood Hits	48
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 1017)	NC score	0.117457 (rank : 238)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	66
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 1018)	NC score	0.118935 (rank : 235)
Query Neighborhood Hits	288	Target Neighborhood Hits	905	Shared Neighborhood Hits	67
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

NPHP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	288	Target Neighborhood Hits	288	Shared Neighborhood Hits	288
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
NC score	0.923972 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	288	Target Neighborhood Hits	267	Shared Neighborhood Hits	186
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CRKL_HUMAN
NC score	0.537539 (rank : 3)	θ value	7.59969e-07 (rank : 5)
Query Neighborhood Hits	288	Target Neighborhood Hits	313	Shared Neighborhood Hits	173
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.534570 (rank : 4)	θ value	1.29631e-06 (rank : 7)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	170
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.527125 (rank : 5)	θ value	2.61198e-07 (rank : 4)
Query Neighborhood Hits	288	Target Neighborhood Hits	314	Shared Neighborhood Hits	168
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.525456 (rank : 6)	θ value	2.61198e-07 (rank : 3)
Query Neighborhood Hits	288	Target Neighborhood Hits	308	Shared Neighborhood Hits	169
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRB2_HUMAN
NC score	0.510268 (rank : 7)	θ value	0.00035302 (rank : 28)
Query Neighborhood Hits	288	Target Neighborhood Hits	310	Shared Neighborhood Hits	170
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.509846 (rank : 8)	θ value	0.00035302 (rank : 29)
Query Neighborhood Hits	288	Target Neighborhood Hits	312	Shared Neighborhood Hits	170
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP_HUMAN
NC score	0.506932 (rank : 9)	θ value	0.000461057 (rank : 31)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	174
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.506656 (rank : 10)	θ value	0.00134147 (rank : 44)
Query Neighborhood Hits	288	Target Neighborhood Hits	310	Shared Neighborhood Hits	172
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_MOUSE
NC score	0.501133 (rank : 11)	θ value	0.00102713 (rank : 38)
Query Neighborhood Hits	288	Target Neighborhood Hits	309	Shared Neighborhood Hits	173
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.497520 (rank : 12)	θ value	0.0330416 (rank : 83)
Query Neighborhood Hits	288	Target Neighborhood Hits	312	Shared Neighborhood Hits	169
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PPIP1_MOUSE
NC score	0.476414 (rank : 13)	θ value	6.43352e-06 (rank : 10)
Query Neighborhood Hits	288	Target Neighborhood Hits	377	Shared Neighborhood Hits	185
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PPIP1_HUMAN
NC score	0.473512 (rank : 14)	θ value	4.92598e-06 (rank : 9)
Query Neighborhood Hits	288	Target Neighborhood Hits	389	Shared Neighborhood Hits	180
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

NCF1_MOUSE
NC score	0.465287 (rank : 15)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	145
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

GRAP2_MOUSE
NC score	0.460392 (rank : 16)	θ value	0.279714 (rank : 135)
Query Neighborhood Hits	288	Target Neighborhood Hits	297	Shared Neighborhood Hits	166
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCF1_HUMAN
NC score	0.459407 (rank : 17)	θ value	0.000158464 (rank : 20)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	138
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

GRAP2_HUMAN
NC score	0.457505 (rank : 18)	θ value	0.365318 (rank : 141)
Query Neighborhood Hits	288	Target Neighborhood Hits	304	Shared Neighborhood Hits	168
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF2_HUMAN
NC score	0.448677 (rank : 19)	θ value	0.00134147 (rank : 43)
Query Neighborhood Hits	288	Target Neighborhood Hits	229	Shared Neighborhood Hits	140
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CD2AP_HUMAN
NC score	0.433705 (rank : 20)	θ value	0.0330416 (rank : 82)
Query Neighborhood Hits	288	Target Neighborhood Hits	315	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

STAM2_MOUSE
NC score	0.431412 (rank : 21)	θ value	0.00298849 (rank : 51)
Query Neighborhood Hits	288	Target Neighborhood Hits	285	Shared Neighborhood Hits	170
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.430914 (rank : 22)	θ value	0.00102713 (rank : 40)
Query Neighborhood Hits	288	Target Neighborhood Hits	288	Shared Neighborhood Hits	167
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_MOUSE
NC score	0.428482 (rank : 23)	θ value	0.00390308 (rank : 53)
Query Neighborhood Hits	288	Target Neighborhood Hits	273	Shared Neighborhood Hits	164
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.428002 (rank : 24)	θ value	0.00228821 (rank : 49)
Query Neighborhood Hits	288	Target Neighborhood Hits	271	Shared Neighborhood Hits	164
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_MOUSE
NC score	0.426690 (rank : 25)	θ value	0.00134147 (rank : 42)
Query Neighborhood Hits	288	Target Neighborhood Hits	266	Shared Neighborhood Hits	146
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CD2AP_MOUSE
NC score	0.426653 (rank : 26)	θ value	0.0563607 (rank : 93)
Query Neighborhood Hits	288	Target Neighborhood Hits	336	Shared Neighborhood Hits	170
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_HUMAN
NC score	0.422842 (rank : 27)	θ value	0.0113563 (rank : 64)
Query Neighborhood Hits	288	Target Neighborhood Hits	341	Shared Neighborhood Hits	161
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ABI2_HUMAN
NC score	0.422404 (rank : 28)	θ value	0.00134147 (rank : 41)
Query Neighborhood Hits	288	Target Neighborhood Hits	350	Shared Neighborhood Hits	147
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3K1_MOUSE
NC score	0.421060 (rank : 29)	θ value	0.0330416 (rank : 84)
Query Neighborhood Hits	288	Target Neighborhood Hits	332	Shared Neighborhood Hits	163
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

VINEX_HUMAN
NC score	0.418087 (rank : 30)	θ value	0.125558 (rank : 126)
Query Neighborhood Hits	288	Target Neighborhood Hits	270	Shared Neighborhood Hits	159
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.415006 (rank : 31)	θ value	0.365318 (rank : 150)
Query Neighborhood Hits	288	Target Neighborhood Hits	286	Shared Neighborhood Hits	158
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_HUMAN
NC score	0.406899 (rank : 32)	θ value	0.0330416 (rank : 85)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	169
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ABI1_MOUSE
NC score	0.401482 (rank : 33)	θ value	0.00665767 (rank : 57)
Query Neighborhood Hits	288	Target Neighborhood Hits	246	Shared Neighborhood Hits	140
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SRBS1_MOUSE
NC score	0.396515 (rank : 34)	θ value	0.0961366 (rank : 118)
Query Neighborhood Hits	288	Target Neighborhood Hits	409	Shared Neighborhood Hits	160
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN2_MOUSE
NC score	0.393897 (rank : 35)	θ value	0.0961366 (rank : 117)
Query Neighborhood Hits	288	Target Neighborhood Hits	382	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRC8_MOUSE
NC score	0.385718 (rank : 36)	θ value	0.00509761 (rank : 56)
Query Neighborhood Hits	288	Target Neighborhood Hits	292	Shared Neighborhood Hits	153
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PACN2_HUMAN
NC score	0.385218 (rank : 37)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	288	Target Neighborhood Hits	339	Shared Neighborhood Hits	171
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRC8_HUMAN
NC score	0.384529 (rank : 38)	θ value	0.0330416 (rank : 86)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PACN1_HUMAN
NC score	0.384123 (rank : 39)	θ value	0.0961366 (rank : 116)
Query Neighborhood Hits	288	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN3_HUMAN
NC score	0.384068 (rank : 40)	θ value	0.000786445 (rank : 35)
Query Neighborhood Hits	288	Target Neighborhood Hits	385	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN1_MOUSE
NC score	0.383831 (rank : 41)	θ value	0.0431538 (rank : 90)
Query Neighborhood Hits	288	Target Neighborhood Hits	283	Shared Neighborhood Hits	162
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABI1_HUMAN
NC score	0.382578 (rank : 42)	θ value	0.0252991 (rank : 78)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PACN3_MOUSE
NC score	0.380607 (rank : 43)	θ value	0.00175202 (rank : 46)
Query Neighborhood Hits	288	Target Neighborhood Hits	380	Shared Neighborhood Hits	167
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

STAC_HUMAN
NC score	0.377750 (rank : 44)	θ value	0.0563607 (rank : 98)
Query Neighborhood Hits	288	Target Neighborhood Hits	276	Shared Neighborhood Hits	151
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_MOUSE
NC score	0.377174 (rank : 45)	θ value	0.0252991 (rank : 79)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

HCLS1_MOUSE
NC score	0.375650 (rank : 46)	θ value	0.365318 (rank : 142)
Query Neighborhood Hits	288	Target Neighborhood Hits	329	Shared Neighborhood Hits	139
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.372413 (rank : 47)	θ value	1.06291 (rank : 172)
Query Neighborhood Hits	288	Target Neighborhood Hits	358	Shared Neighborhood Hits	140
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI3_HUMAN
NC score	0.369362 (rank : 48)	θ value	0.0563607 (rank : 92)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	124
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DNMBP_HUMAN
NC score	0.365599 (rank : 49)	θ value	0.279714 (rank : 133)
Query Neighborhood Hits	288	Target Neighborhood Hits	413	Shared Neighborhood Hits	169
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC_MOUSE
NC score	0.364515 (rank : 50)	θ value	0.47712 (rank : 154)
Query Neighborhood Hits	288	Target Neighborhood Hits	268	Shared Neighborhood Hits	146
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DNMBP_MOUSE
NC score	0.363368 (rank : 51)	θ value	0.00665767 (rank : 58)
Query Neighborhood Hits	288	Target Neighborhood Hits	435	Shared Neighborhood Hits	167
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L3_MOUSE
NC score	0.363150 (rank : 52)	θ value	0.0148317 (rank : 69)
Query Neighborhood Hits	288	Target Neighborhood Hits	168	Shared Neighborhood Hits	125
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ITSN2_HUMAN
NC score	0.361514 (rank : 53)	θ value	1.69304e-06 (rank : 8)
Query Neighborhood Hits	288	Target Neighborhood Hits	1173	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ES8L3_HUMAN
NC score	0.351180 (rank : 54)	θ value	0.0961366 (rank : 110)
Query Neighborhood Hits	288	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ITSN2_MOUSE
NC score	0.347897 (rank : 55)	θ value	9.92553e-07 (rank : 6)
Query Neighborhood Hits	288	Target Neighborhood Hits	1371	Shared Neighborhood Hits	235
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG7_MOUSE
NC score	0.346855 (rank : 56)	θ value	1.38821 (rank : 175)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	178
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

AHI1_HUMAN
NC score	0.345856 (rank : 57)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	288	Target Neighborhood Hits	537	Shared Neighborhood Hits	168
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NCF4_MOUSE
NC score	0.342294 (rank : 58)	θ value	4.03905 (rank : 231)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	120
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ITSN1_MOUSE
NC score	0.338646 (rank : 59)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	288	Target Neighborhood Hits	1669	Shared Neighborhood Hits	251
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV_HUMAN
NC score	0.337784 (rank : 60)	θ value	0.125558 (rank : 125)
Query Neighborhood Hits	288	Target Neighborhood Hits	452	Shared Neighborhood Hits	159
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_MOUSE
NC score	0.335617 (rank : 61)	θ value	0.00298849 (rank : 50)
Query Neighborhood Hits	288	Target Neighborhood Hits	496	Shared Neighborhood Hits	164
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ITSN1_HUMAN
NC score	0.335453 (rank : 62)	θ value	0.000270298 (rank : 23)
Query Neighborhood Hits	288	Target Neighborhood Hits	1757	Shared Neighborhood Hits	246
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VAV_MOUSE
NC score	0.333036 (rank : 63)	θ value	0.163984 (rank : 132)
Query Neighborhood Hits	288	Target Neighborhood Hits	430	Shared Neighborhood Hits	161
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG7_HUMAN
NC score	0.331900 (rank : 64)	θ value	4.03905 (rank : 226)
Query Neighborhood Hits	288	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

STAC3_HUMAN
NC score	0.330679 (rank : 65)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	134
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PLCG1_MOUSE
NC score	0.328466 (rank : 66)	θ value	0.125558 (rank : 120)
Query Neighborhood Hits	288	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ES8L1_MOUSE
NC score	0.325557 (rank : 67)	θ value	9.29e-05 (rank : 16)
Query Neighborhood Hits	288	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

STAC3_MOUSE
NC score	0.325234 (rank : 68)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	288	Target Neighborhood Hits	232	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PLCG2_HUMAN
NC score	0.324573 (rank : 69)	θ value	0.365318 (rank : 145)
Query Neighborhood Hits	288	Target Neighborhood Hits	280	Shared Neighborhood Hits	146
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ES8L2_HUMAN
NC score	0.323192 (rank : 70)	θ value	0.0563607 (rank : 94)
Query Neighborhood Hits	288	Target Neighborhood Hits	193	Shared Neighborhood Hits	122
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_HUMAN
NC score	0.323139 (rank : 71)	θ value	0.0193708 (rank : 74)
Query Neighborhood Hits	288	Target Neighborhood Hits	162	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

OSTF1_HUMAN
NC score	0.322581 (rank : 72)	θ value	0.47712 (rank : 152)
Query Neighborhood Hits	288	Target Neighborhood Hits	466	Shared Neighborhood Hits	159
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ES8L2_MOUSE
NC score	0.322315 (rank : 73)	θ value	0.0148317 (rank : 68)
Query Neighborhood Hits	288	Target Neighborhood Hits	169	Shared Neighborhood Hits	118
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

PLCG1_HUMAN
NC score	0.321389 (rank : 74)	θ value	0.125558 (rank : 119)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G2_HUMAN
NC score	0.321243 (rank : 75)	θ value	2.36792 (rank : 209)
Query Neighborhood Hits	288	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SLAP2_MOUSE
NC score	0.320950 (rank : 76)	θ value	0.125558 (rank : 122)
Query Neighborhood Hits	288	Target Neighborhood Hits	136	Shared Neighborhood Hits	65
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SH3G3_MOUSE
NC score	0.316030 (rank : 77)	θ value	2.36792 (rank : 210)
Query Neighborhood Hits	288	Target Neighborhood Hits	236	Shared Neighborhood Hits	153
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VAV3_HUMAN
NC score	0.314254 (rank : 78)	θ value	0.365318 (rank : 149)
Query Neighborhood Hits	288	Target Neighborhood Hits	398	Shared Neighborhood Hits	157
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG6_MOUSE
NC score	0.313837 (rank : 79)	θ value	0.47712 (rank : 151)
Query Neighborhood Hits	288	Target Neighborhood Hits	394	Shared Neighborhood Hits	175
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SLAP2_HUMAN
NC score	0.312991 (rank : 80)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	288	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ANM2_HUMAN
NC score	0.309879 (rank : 81)	θ value	0.000602161 (rank : 33)
Query Neighborhood Hits	288	Target Neighborhood Hits	175	Shared Neighborhood Hits	135
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SH3G2_MOUSE
NC score	0.309149 (rank : 82)	θ value	8.99809 (rank : 285)
Query Neighborhood Hits	288	Target Neighborhood Hits	319	Shared Neighborhood Hits	166
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

OSTF1_MOUSE
NC score	0.307450 (rank : 83)	θ value	0.62314 (rank : 160)
Query Neighborhood Hits	288	Target Neighborhood Hits	467	Shared Neighborhood Hits	159
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

VAV3_MOUSE
NC score	0.307349 (rank : 84)	θ value	0.62314 (rank : 161)
Query Neighborhood Hits	288	Target Neighborhood Hits	404	Shared Neighborhood Hits	157
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

RHG04_HUMAN
NC score	0.305813 (rank : 85)	θ value	0.0431538 (rank : 91)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	148
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SPN90_HUMAN
NC score	0.304331 (rank : 86)	θ value	0.0113563 (rank : 65)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

BCAR1_MOUSE
NC score	0.300611 (rank : 87)	θ value	0.0193708 (rank : 73)
Query Neighborhood Hits	288	Target Neighborhood Hits	438	Shared Neighborhood Hits	140
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ARHG6_HUMAN
NC score	0.299398 (rank : 88)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	288	Target Neighborhood Hits	376	Shared Neighborhood Hits	169
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV2_HUMAN
NC score	0.298739 (rank : 89)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	288	Target Neighborhood Hits	453	Shared Neighborhood Hits	163
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

DBNL_HUMAN
NC score	0.298444 (rank : 90)	θ value	2.36792 (rank : 203)
Query Neighborhood Hits	288	Target Neighborhood Hits	244	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV2_MOUSE
NC score	0.298443 (rank : 91)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	288	Target Neighborhood Hits	456	Shared Neighborhood Hits	164
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SH3G3_HUMAN
NC score	0.297630 (rank : 92)	θ value	5.27518 (rank : 248)
Query Neighborhood Hits	288	Target Neighborhood Hits	222	Shared Neighborhood Hits	148
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRGP2_MOUSE
NC score	0.296305 (rank : 93)	θ value	0.000461057 (rank : 32)
Query Neighborhood Hits	288	Target Neighborhood Hits	324	Shared Neighborhood Hits	143
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

NCF4_HUMAN
NC score	0.296193 (rank : 94)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	288	Target Neighborhood Hits	161	Shared Neighborhood Hits	109
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRGP1_HUMAN
NC score	0.295714 (rank : 95)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	288	Target Neighborhood Hits	390	Shared Neighborhood Hits	153
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ANM2_MOUSE
NC score	0.295124 (rank : 96)	θ value	0.00102713 (rank : 37)
Query Neighborhood Hits	288	Target Neighborhood Hits	175	Shared Neighborhood Hits	134
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FNBP2_HUMAN
NC score	0.294281 (rank : 97)	θ value	0.000158464 (rank : 19)
Query Neighborhood Hits	288	Target Neighborhood Hits	432	Shared Neighborhood Hits	152
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP2_HUMAN
NC score	0.294147 (rank : 98)	θ value	0.00020696 (rank : 22)
Query Neighborhood Hits	288	Target Neighborhood Hits	331	Shared Neighborhood Hits	141
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

DBNL_MOUSE
NC score	0.292942 (rank : 99)	θ value	2.36792 (rank : 204)
Query Neighborhood Hits	288	Target Neighborhood Hits	306	Shared Neighborhood Hits	133
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EPS8_MOUSE
NC score	0.292539 (rank : 100)	θ value	0.0736092 (rank : 102)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	118
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BCAR1_HUMAN
NC score	0.289943 (rank : 101)	θ value	0.0252991 (rank : 80)
Query Neighborhood Hits	288	Target Neighborhood Hits	554	Shared Neighborhood Hits	143
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SH3G1_MOUSE
NC score	0.289541 (rank : 102)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	167
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CIP4_HUMAN
NC score	0.288848 (rank : 103)	θ value	0.0961366 (rank : 108)
Query Neighborhood Hits	288	Target Neighborhood Hits	374	Shared Neighborhood Hits	118
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SH3G1_HUMAN
NC score	0.287241 (rank : 104)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	288	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

EPS8_HUMAN
NC score	0.286370 (rank : 105)	θ value	0.0736092 (rank : 101)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SPN90_MOUSE
NC score	0.281988 (rank : 106)	θ value	0.0113563 (rank : 66)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

NEBL_HUMAN
NC score	0.281868 (rank : 107)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	288	Target Neighborhood Hits	457	Shared Neighborhood Hits	164
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

EFS_MOUSE
NC score	0.275548 (rank : 108)	θ value	1.38821 (rank : 178)
Query Neighborhood Hits	288	Target Neighborhood Hits	389	Shared Neighborhood Hits	133
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

LASP1_HUMAN
NC score	0.274275 (rank : 109)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	127
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SLAP1_HUMAN
NC score	0.273390 (rank : 110)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	288	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

CASL_HUMAN
NC score	0.272159 (rank : 111)	θ value	0.0961366 (rank : 107)
Query Neighborhood Hits	288	Target Neighborhood Hits	259	Shared Neighborhood Hits	128
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NOXO1_MOUSE
NC score	0.271938 (rank : 112)	θ value	3.0926 (rank : 221)
Query Neighborhood Hits	288	Target Neighborhood Hits	114	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

EFS_HUMAN
NC score	0.271857 (rank : 113)	θ value	1.38821 (rank : 177)
Query Neighborhood Hits	288	Target Neighborhood Hits	348	Shared Neighborhood Hits	130
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

LASP1_MOUSE
NC score	0.271292 (rank : 114)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	288	Target Neighborhood Hits	297	Shared Neighborhood Hits	127
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CASL_MOUSE
NC score	0.269826 (rank : 115)	θ value	0.163984 (rank : 127)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	128
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

SLAP1_MOUSE
NC score	0.269780 (rank : 116)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	288	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

RUSC1_HUMAN
NC score	0.262767 (rank : 117)	θ value	0.47712 (rank : 153)
Query Neighborhood Hits	288	Target Neighborhood Hits	226	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CT032_HUMAN
NC score	0.257513 (rank : 118)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	288	Target Neighborhood Hits	235	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

SNX18_MOUSE
NC score	0.250647 (rank : 119)	θ value	0.365318 (rank : 146)
Query Neighborhood Hits	288	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.248018 (rank : 120)	θ value	0.279714 (rank : 138)
Query Neighborhood Hits	288	Target Neighborhood Hits	207	Shared Neighborhood Hits	112
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SPTA2_HUMAN
NC score	0.247907 (rank : 121)	θ value	0.0113563 (rank : 67)
Query Neighborhood Hits	288	Target Neighborhood Hits	888	Shared Neighborhood Hits	206
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NEBU_HUMAN
NC score	0.247833 (rank : 122)	θ value	0.279714 (rank : 137)
Query Neighborhood Hits	288	Target Neighborhood Hits	420	Shared Neighborhood Hits	157
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ARHG4_HUMAN
NC score	0.243217 (rank : 123)	θ value	3.0926 (rank : 211)
Query Neighborhood Hits	288	Target Neighborhood Hits	242	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
NC score	0.228720 (rank : 124)	θ value	0.62314 (rank : 155)
Query Neighborhood Hits	288	Target Neighborhood Hits	234	Shared Neighborhood Hits	132
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.227103 (rank : 125)	θ value	3.0926 (rank : 212)
Query Neighborhood Hits	288	Target Neighborhood Hits	235	Shared Neighborhood Hits	131
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SPTA1_HUMAN
NC score	0.226086 (rank : 126)	θ value	0.0148317 (rank : 70)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	199
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

YES_MOUSE
NC score	0.225853 (rank : 127)	θ value	0.00035302 (rank : 30)
Query Neighborhood Hits	288	Target Neighborhood Hits	1052	Shared Neighborhood Hits	172
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
NC score	0.225658 (rank : 128)	θ value	0.00228821 (rank : 47)
Query Neighborhood Hits	288	Target Neighborhood Hits	1067	Shared Neighborhood Hits	164
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.225267 (rank : 129)	θ value	0.000270298 (rank : 25)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	171
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.224749 (rank : 130)	θ value	0.00228821 (rank : 48)
Query Neighborhood Hits	288	Target Neighborhood Hits	1069	Shared Neighborhood Hits	169
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SPTA1_MOUSE
NC score	0.223926 (rank : 131)	θ value	0.279714 (rank : 139)
Query Neighborhood Hits	288	Target Neighborhood Hits	675	Shared Neighborhood Hits	184
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC_HUMAN
NC score	0.221859 (rank : 132)	θ value	0.000786445 (rank : 36)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.221555 (rank : 133)	θ value	0.00869519 (rank : 61)
Query Neighborhood Hits	288	Target Neighborhood Hits	1073	Shared Neighborhood Hits	170
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

PEX13_HUMAN
NC score	0.218929 (rank : 134)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	288	Target Neighborhood Hits	128	Shared Neighborhood Hits	96
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

FYN_HUMAN
NC score	0.218188 (rank : 135)	θ value	0.00869519 (rank : 60)
Query Neighborhood Hits	288	Target Neighborhood Hits	1078	Shared Neighborhood Hits	170
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

RUSC1_MOUSE
NC score	0.218125 (rank : 136)	θ value	4.03905 (rank : 235)
Query Neighborhood Hits	288	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

IASPP_HUMAN
NC score	0.217671 (rank : 137)	θ value	0.0736092 (rank : 103)
Query Neighborhood Hits	288	Target Neighborhood Hits	688	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NOXO1_HUMAN
NC score	0.216158 (rank : 138)	θ value	3.0926 (rank : 220)
Query Neighborhood Hits	288	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PEX13_MOUSE
NC score	0.216099 (rank : 139)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	288	Target Neighborhood Hits	126	Shared Neighborhood Hits	99
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

BTK_HUMAN
NC score	0.212859 (rank : 140)	θ value	0.000602161 (rank : 34)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	167
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.212392 (rank : 141)	θ value	0.00020696 (rank : 21)
Query Neighborhood Hits	288	Target Neighborhood Hits	1017	Shared Neighborhood Hits	163
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCK_HUMAN
NC score	0.204927 (rank : 142)	θ value	0.0961366 (rank : 111)
Query Neighborhood Hits	288	Target Neighborhood Hits	1035	Shared Neighborhood Hits	159
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.204150 (rank : 143)	θ value	0.0330416 (rank : 87)
Query Neighborhood Hits	288	Target Neighborhood Hits	1033	Shared Neighborhood Hits	154
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

RASA1_HUMAN
NC score	0.203845 (rank : 144)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	288	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RIMB2_HUMAN
NC score	0.202579 (rank : 145)	θ value	0.125558 (rank : 121)
Query Neighborhood Hits	288	Target Neighborhood Hits	263	Shared Neighborhood Hits	106
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

HCK_MOUSE
NC score	0.202166 (rank : 146)	θ value	0.0961366 (rank : 112)
Query Neighborhood Hits	288	Target Neighborhood Hits	1029	Shared Neighborhood Hits	160
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

IASPP_MOUSE
NC score	0.199715 (rank : 147)	θ value	0.163984 (rank : 128)
Query Neighborhood Hits	288	Target Neighborhood Hits	1024	Shared Neighborhood Hits	142
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TXK_MOUSE
NC score	0.197246 (rank : 148)	θ value	3.19293e-05 (rank : 13)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	142
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SNX9_HUMAN
NC score	0.196986 (rank : 149)	θ value	0.365318 (rank : 147)
Query Neighborhood Hits	288	Target Neighborhood Hits	148	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

BLK_MOUSE
NC score	0.196055 (rank : 150)	θ value	0.0736092 (rank : 100)
Query Neighborhood Hits	288	Target Neighborhood Hits	992	Shared Neighborhood Hits	132
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_HUMAN
NC score	0.196035 (rank : 151)	θ value	0.00869519 (rank : 62)
Query Neighborhood Hits	288	Target Neighborhood Hits	1022	Shared Neighborhood Hits	152
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.195399 (rank : 152)	θ value	0.0431538 (rank : 89)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	148
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TEC_HUMAN
NC score	0.195268 (rank : 153)	θ value	2.44474e-05 (rank : 11)
Query Neighborhood Hits	288	Target Neighborhood Hits	1006	Shared Neighborhood Hits	146
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
NC score	0.195244 (rank : 154)	θ value	3.19293e-05 (rank : 12)
Query Neighborhood Hits	288	Target Neighborhood Hits	1006	Shared Neighborhood Hits	145
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
NC score	0.194608 (rank : 155)	θ value	0.0736092 (rank : 99)
Query Neighborhood Hits	288	Target Neighborhood Hits	994	Shared Neighborhood Hits	138
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MYO1F_HUMAN
NC score	0.194567 (rank : 156)	θ value	0.00665767 (rank : 59)
Query Neighborhood Hits	288	Target Neighborhood Hits	275	Shared Neighborhood Hits	159
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH21B_MOUSE
NC score	0.193526 (rank : 157)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

FRK_HUMAN
NC score	0.192909 (rank : 158)	θ value	0.00509761 (rank : 54)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ASPP1_HUMAN
NC score	0.192346 (rank : 159)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	288	Target Neighborhood Hits	956	Shared Neighborhood Hits	170
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX9_MOUSE
NC score	0.191286 (rank : 160)	θ value	0.125558 (rank : 123)
Query Neighborhood Hits	288	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

RIMB2_MOUSE
NC score	0.190927 (rank : 161)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	288	Target Neighborhood Hits	246	Shared Neighborhood Hits	106
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

MYO1F_MOUSE
NC score	0.190218 (rank : 162)	θ value	0.0961366 (rank : 114)
Query Neighborhood Hits	288	Target Neighborhood Hits	262	Shared Neighborhood Hits	162
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

TXK_HUMAN
NC score	0.189316 (rank : 163)	θ value	0.000270298 (rank : 24)
Query Neighborhood Hits	288	Target Neighborhood Hits	971	Shared Neighborhood Hits	134
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ASPP1_MOUSE
NC score	0.188403 (rank : 164)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	288	Target Neighborhood Hits	1244	Shared Neighborhood Hits	179
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ITK_HUMAN
NC score	0.185988 (rank : 165)	θ value	0.0113563 (rank : 63)
Query Neighborhood Hits	288	Target Neighborhood Hits	1016	Shared Neighborhood Hits	139
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MYO1E_HUMAN
NC score	0.185766 (rank : 166)	θ value	0.0193708 (rank : 77)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	164
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

LCK_HUMAN
NC score	0.182402 (rank : 167)	θ value	0.163984 (rank : 129)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	122
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

P85A_MOUSE
NC score	0.181136 (rank : 168)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	288	Target Neighborhood Hits	435	Shared Neighborhood Hits	125
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

LCK_MOUSE
NC score	0.180670 (rank : 169)	θ value	0.163984 (rank : 130)
Query Neighborhood Hits	288	Target Neighborhood Hits	981	Shared Neighborhood Hits	121
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PTK6_MOUSE
NC score	0.180580 (rank : 170)	θ value	0.00390308 (rank : 52)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SH21B_HUMAN
NC score	0.179722 (rank : 171)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	50
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

ABL1_HUMAN
NC score	0.177570 (rank : 172)	θ value	0.0193708 (rank : 71)
Query Neighborhood Hits	288	Target Neighborhood Hits	1220	Shared Neighborhood Hits	135
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.177324 (rank : 173)	θ value	0.0193708 (rank : 72)
Query Neighborhood Hits	288	Target Neighborhood Hits	1178	Shared Neighborhood Hits	131
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.177197 (rank : 174)	θ value	0.00175202 (rank : 45)
Query Neighborhood Hits	288	Target Neighborhood Hits	1045	Shared Neighborhood Hits	122
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

P85A_HUMAN
NC score	0.177098 (rank : 175)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	288	Target Neighborhood Hits	479	Shared Neighborhood Hits	126
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CSK_MOUSE
NC score	0.177090 (rank : 176)	θ value	0.00035302 (rank : 27)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	131
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.176950 (rank : 177)	θ value	0.00035302 (rank : 26)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	131
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ARHG4_MOUSE
NC score	0.175994 (rank : 178)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	288	Target Neighborhood Hits	185	Shared Neighborhood Hits	93
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PTK6_HUMAN
NC score	0.175768 (rank : 179)	θ value	0.0736092 (rank : 105)
Query Neighborhood Hits	288	Target Neighborhood Hits	1020	Shared Neighborhood Hits	151
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ITK_MOUSE
NC score	0.175136 (rank : 180)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	288	Target Neighborhood Hits	985	Shared Neighborhood Hits	125
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

P85B_HUMAN
NC score	0.170103 (rank : 181)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	288	Target Neighborhood Hits	543	Shared Neighborhood Hits	113
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
NC score	0.168619 (rank : 182)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	288	Target Neighborhood Hits	519	Shared Neighborhood Hits	114
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DAPP1_HUMAN
NC score	0.166690 (rank : 183)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
NC score	0.166122 (rank : 184)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SH21A_MOUSE
NC score	0.163132 (rank : 185)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	288	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

P55G_HUMAN
NC score	0.162818 (rank : 186)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	288	Target Neighborhood Hits	451	Shared Neighborhood Hits	102
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

RHG26_HUMAN
NC score	0.158367 (rank : 187)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	288	Target Neighborhood Hits	281	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

P55G_MOUSE
NC score	0.157520 (rank : 188)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	288	Target Neighborhood Hits	401	Shared Neighborhood Hits	98
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ASPP2_HUMAN
NC score	0.155999 (rank : 189)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	288	Target Neighborhood Hits	1156	Shared Neighborhood Hits	173
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SH21A_HUMAN
NC score	0.155831 (rank : 190)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	288	Target Neighborhood Hits	89	Shared Neighborhood Hits	45
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SRMS_MOUSE
NC score	0.154699 (rank : 191)	θ value	3.0926 (rank : 225)
Query Neighborhood Hits	288	Target Neighborhood Hits	964	Shared Neighborhood Hits	104
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

M3KL4_HUMAN
NC score	0.152825 (rank : 192)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	288	Target Neighborhood Hits	1087	Shared Neighborhood Hits	170
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MPP6_HUMAN
NC score	0.150446 (rank : 193)	θ value	0.0193708 (rank : 75)
Query Neighborhood Hits	288	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SRMS_HUMAN
NC score	0.149259 (rank : 194)	θ value	1.81305 (rank : 195)
Query Neighborhood Hits	288	Target Neighborhood Hits	946	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

RIMB1_MOUSE
NC score	0.148546 (rank : 195)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	288	Target Neighborhood Hits	1376	Shared Neighborhood Hits	195
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHE_MOUSE
NC score	0.148293 (rank : 196)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	288	Target Neighborhood Hits	169	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MPP6_MOUSE
NC score	0.147278 (rank : 197)	θ value	0.0193708 (rank : 76)
Query Neighborhood Hits	288	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

GRB14_MOUSE
NC score	0.145864 (rank : 198)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	288	Target Neighborhood Hits	149	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

M3K11_HUMAN
NC score	0.145240 (rank : 199)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	288	Target Neighborhood Hits	1136	Shared Neighborhood Hits	155
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RIMB1_HUMAN
NC score	0.142897 (rank : 200)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	288	Target Neighborhood Hits	1479	Shared Neighborhood Hits	180
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MATK_MOUSE
NC score	0.142334 (rank : 201)	θ value	1.38821 (rank : 179)
Query Neighborhood Hits	288	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SHE_HUMAN
NC score	0.142333 (rank : 202)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	288	Target Neighborhood Hits	164	Shared Neighborhood Hits	55
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

HSH2D_HUMAN
NC score	0.141587 (rank : 203)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	288	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

M3K9_HUMAN
NC score	0.141475 (rank : 204)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	288	Target Neighborhood Hits	1123	Shared Neighborhood Hits	160
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.141386 (rank : 205)	θ value	0.0736092 (rank : 104)
Query Neighborhood Hits	288	Target Neighborhood Hits	1071	Shared Neighborhood Hits	161
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MATK_HUMAN
NC score	0.141296 (rank : 206)	θ value	0.365318 (rank : 144)
Query Neighborhood Hits	288	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

GRB14_HUMAN
NC score	0.139365 (rank : 207)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	55
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

APS_HUMAN
NC score	0.138182 (rank : 208)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	288	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NGEF_MOUSE
NC score	0.137188 (rank : 209)	θ value	4.03905 (rank : 232)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FER_HUMAN
NC score	0.136075 (rank : 210)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	288	Target Neighborhood Hits	1278	Shared Neighborhood Hits	124
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SHB_MOUSE
NC score	0.136003 (rank : 211)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
NC score	0.134102 (rank : 212)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	288	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
NC score	0.132777 (rank : 213)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	288	Target Neighborhood Hits	180	Shared Neighborhood Hits	57
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHB_HUMAN
NC score	0.132511 (rank : 214)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	288	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PPIP2_MOUSE
NC score	0.132133 (rank : 215)	θ value	1.81305 (rank : 194)
Query Neighborhood Hits	288	Target Neighborhood Hits	308	Shared Neighborhood Hits	57
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

BMX_MOUSE
NC score	0.131770 (rank : 216)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	288	Target Neighborhood Hits	912	Shared Neighborhood Hits	62
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

DDEF1_MOUSE
NC score	0.131241 (rank : 217)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	288	Target Neighborhood Hits	592	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

BMX_HUMAN
NC score	0.130930 (rank : 218)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	64
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

NGEF_HUMAN
NC score	0.130687 (rank : 219)	θ value	8.99809 (rank : 283)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

LNK_HUMAN
NC score	0.128573 (rank : 220)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHC3_MOUSE
NC score	0.128486 (rank : 221)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	55
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC2_HUMAN
NC score	0.126835 (rank : 222)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	288	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

LNK_MOUSE
NC score	0.126329 (rank : 223)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	288	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SLY_MOUSE
NC score	0.125773 (rank : 224)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	288	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

GRB7_MOUSE
NC score	0.125768 (rank : 225)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	288	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHC2_MOUSE
NC score	0.124409 (rank : 226)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	288	Target Neighborhood Hits	144	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

PPIP2_HUMAN
NC score	0.124322 (rank : 227)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	288	Target Neighborhood Hits	254	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

SH24A_HUMAN
NC score	0.124009 (rank : 228)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	288	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHD_MOUSE
NC score	0.123767 (rank : 229)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	288	Target Neighborhood Hits	137	Shared Neighborhood Hits	56
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_HUMAN
NC score	0.123660 (rank : 230)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

TCGAP_MOUSE
NC score	0.122101 (rank : 231)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	288	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MPP5_HUMAN
NC score	0.120581 (rank : 232)	θ value	0.0563607 (rank : 95)
Query Neighborhood Hits	288	Target Neighborhood Hits	231	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.119874 (rank : 233)	θ value	0.0563607 (rank : 96)
Query Neighborhood Hits	288	Target Neighborhood Hits	226	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SHC3_HUMAN
NC score	0.119068 (rank : 234)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	288	Target Neighborhood Hits	155	Shared Neighborhood Hits	49
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ZAP70_MOUSE
NC score	0.118935 (rank : 235)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	288	Target Neighborhood Hits	905	Shared Neighborhood Hits	67
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

DDEF2_MOUSE
NC score	0.118690 (rank : 236)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	288	Target Neighborhood Hits	625	Shared Neighborhood Hits	127
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.118288 (rank : 237)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	288	Target Neighborhood Hits	599	Shared Neighborhood Hits	129
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ZAP70_HUMAN
NC score	0.117457 (rank : 238)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	66
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

GRB7_HUMAN
NC score	0.116560 (rank : 239)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SHAN2_MOUSE
NC score	0.116258 (rank : 240)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	288	Target Neighborhood Hits	446	Shared Neighborhood Hits	92
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

KSYK_MOUSE
NC score	0.115943 (rank : 241)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	67
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.114473 (rank : 242)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	288	Target Neighborhood Hits	901	Shared Neighborhood Hits	66
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

EM55_HUMAN
NC score	0.114093 (rank : 243)	θ value	4.03905 (rank : 229)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ACK1_MOUSE
NC score	0.113289 (rank : 244)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	288	Target Neighborhood Hits	1080	Shared Neighborhood Hits	78
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.112611 (rank : 245)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	288	Target Neighborhood Hits	1140	Shared Neighborhood Hits	77
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ARHG5_HUMAN
NC score	0.110944 (rank : 246)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	288	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FES_HUMAN
NC score	0.110685 (rank : 247)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	288	Target Neighborhood Hits	978	Shared Neighborhood Hits	71
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

APS_MOUSE
NC score	0.109839 (rank : 248)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	288	Target Neighborhood Hits	134	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

STYK1_HUMAN
NC score	0.109281 (rank : 249)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	288	Target Neighborhood Hits	786	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

TCGAP_HUMAN
NC score	0.109201 (rank : 250)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	288	Target Neighborhood Hits	872	Shared Neighborhood Hits	105
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SHAN1_HUMAN
NC score	0.109014 (rank : 251)	θ value	0.0736092 (rank : 106)
Query Neighborhood Hits	288	Target Neighborhood Hits	1041	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

FES_MOUSE
NC score	0.108113 (rank : 252)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	71
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

STYK1_MOUSE
NC score	0.108054 (rank : 253)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	288	Target Neighborhood Hits	779	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

LTK_HUMAN
NC score	0.107297 (rank : 254)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	288	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

SH2D3_MOUSE
NC score	0.107215 (rank : 255)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	288	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

RYK_HUMAN
NC score	0.106895 (rank : 256)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	288	Target Neighborhood Hits	701	Shared Neighborhood Hits	41
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.106349 (rank : 257)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	288	Target Neighborhood Hits	811	Shared Neighborhood Hits	45
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.106333 (rank : 258)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	288	Target Neighborhood Hits	770	Shared Neighborhood Hits	45
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

RYK_MOUSE
NC score	0.105988 (rank : 259)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ALK_HUMAN
NC score	0.105774 (rank : 260)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	288	Target Neighborhood Hits	795	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

TEX14_MOUSE
NC score	0.104353 (rank : 261)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	288	Target Neighborhood Hits	1333	Shared Neighborhood Hits	92
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ROS_HUMAN
NC score	0.104298 (rank : 262)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	288	Target Neighborhood Hits	907	Shared Neighborhood Hits	45
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

SH2D3_HUMAN
NC score	0.104256 (rank : 263)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	288	Target Neighborhood Hits	188	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

PTN11_MOUSE
NC score	0.103336 (rank : 264)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.103322 (rank : 265)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	59
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

AATK_MOUSE
NC score	0.102832 (rank : 266)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

SOCS7_MOUSE
NC score	0.102826 (rank : 267)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	288	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

GRB10_MOUSE
NC score	0.102239 (rank : 268)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	54
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

EM55_MOUSE
NC score	0.102193 (rank : 269)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	288	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

DDR1_MOUSE
NC score	0.102190 (rank : 270)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	288	Target Neighborhood Hits	818	Shared Neighborhood Hits	44
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FAK2_HUMAN
NC score	0.101814 (rank : 271)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

DDR1_HUMAN
NC score	0.101588 (rank : 272)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	288	Target Neighborhood Hits	819	Shared Neighborhood Hits	44
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

FAK2_MOUSE
NC score	0.101450 (rank : 273)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TEX14_HUMAN
NC score	0.101392 (rank : 274)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GRB10_HUMAN
NC score	0.100932 (rank : 275)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	288	Target Neighborhood Hits	147	Shared Neighborhood Hits	55
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

EPHB6_HUMAN
NC score	0.100843 (rank : 276)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	288	Target Neighborhood Hits	912	Shared Neighborhood Hits	45
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

MCF2L_MOUSE
NC score	0.100556 (rank : 277)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	288	Target Neighborhood Hits	255	Shared Neighborhood Hits	63
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

EPHAA_HUMAN
NC score	0.100511 (rank : 278)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

FLT3_MOUSE
NC score	0.100382 (rank : 279)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	44
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

TNK1_HUMAN
NC score	0.100217 (rank : 280)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	288	Target Neighborhood Hits	815	Shared Neighborhood Hits	46
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

MPP4_HUMAN
NC score	0.100170 (rank : 281)	θ value	5.27518 (rank : 243)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	59
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

IGF1R_MOUSE
NC score	0.099894 (rank : 282)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	288	Target Neighborhood Hits	973	Shared Neighborhood Hits	44
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_HUMAN
NC score	0.099787 (rank : 283)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	288	Target Neighborhood Hits	977	Shared Neighborhood Hits	44
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ERBB2_HUMAN
NC score	0.099787 (rank : 284)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	288	Target Neighborhood Hits	1073	Shared Neighborhood Hits	48
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_HUMAN
NC score	0.099766 (rank : 285)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_MOUSE
NC score	0.099715 (rank : 286)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	45
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

FLT3_HUMAN
NC score	0.099525 (rank : 287)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	288	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

AATK_HUMAN
NC score	0.099376 (rank : 288)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	288	Target Neighborhood Hits	1243	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

NTRK1_HUMAN
NC score	0.099368 (rank : 289)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

TNK1_MOUSE
NC score	0.099358 (rank : 290)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	288	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

ERBB4_HUMAN
NC score	0.099334 (rank : 291)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	288	Target Neighborhood Hits	910	Shared Neighborhood Hits	50
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERBB3_MOUSE
NC score	0.099315 (rank : 292)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	288	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

RON_MOUSE
NC score	0.099282 (rank : 293)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	288	Target Neighborhood Hits	836	Shared Neighborhood Hits	44
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

INSRR_HUMAN
NC score	0.099154 (rank : 294)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

RUSC2_HUMAN
NC score	0.098987 (rank : 295)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

MPP4_MOUSE
NC score	0.098877 (rank : 296)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	288	Target Neighborhood Hits	188	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

INSRR_MOUSE
NC score	0.098863 (rank : 297)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	288	Target Neighborhood Hits	961	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

EPHB6_MOUSE
NC score	0.098779 (rank : 298)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	288	Target Neighborhood Hits	906	Shared Neighborhood Hits	44
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

FYB_HUMAN
NC score	0.098663 (rank : 299)	θ value	0.279714 (rank : 134)
Query Neighborhood Hits	288	Target Neighborhood Hits	379	Shared Neighborhood Hits	34
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MERTK_MOUSE
NC score	0.098502 (rank : 300)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	288	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

CSF1R_HUMAN
NC score	0.098486 (rank : 301)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	288	Target Neighborhood Hits	943	Shared Neighborhood Hits	44
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

MERTK_HUMAN
NC score	0.098053 (rank : 302)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	41
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MPP2_HUMAN
NC score	0.097930 (rank : 303)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	288	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

RON_HUMAN
NC score	0.097912 (rank : 304)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	288	Target Neighborhood Hits	842	Shared Neighborhood Hits	44
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

SHLB1_MOUSE
NC score	0.097713 (rank : 305)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	288	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ROR2_MOUSE
NC score	0.097662 (rank : 306)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	288	Target Neighborhood Hits	1000	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

EPHA6_HUMAN
NC score	0.097639 (rank : 307)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
NC score	0.097561 (rank : 308)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	288	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

INSR_HUMAN
NC score	0.097339 (rank : 309)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	288	Target Neighborhood Hits	963	Shared Neighborhood Hits	45
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

FAK1_MOUSE
NC score	0.097222 (rank : 310)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK1_HUMAN
NC score	0.097212 (rank : 311)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

DDR2_HUMAN
NC score	0.097117 (rank : 312)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	288	Target Neighborhood Hits	818	Shared Neighborhood Hits	46
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

MPP2_MOUSE
NC score	0.097064 (rank : 313)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	288	Target Neighborhood Hits	189	Shared Neighborhood Hits	66
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

INSR_MOUSE
NC score	0.096946 (rank : 314)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	288	Target Neighborhood Hits	968	Shared Neighborhood Hits	46
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

PGFRB_MOUSE
NC score	0.096853 (rank : 315)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHA5_MOUSE
NC score	0.096838 (rank : 316)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	44
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

NTRK3_HUMAN
NC score	0.096745 (rank : 317)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	288	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

LCP2_MOUSE
NC score	0.096691 (rank : 318)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PGFRA_MOUSE
NC score	0.096672 (rank : 319)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	288	Target Neighborhood Hits	975	Shared Neighborhood Hits	44
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

SH22A_MOUSE
NC score	0.096663 (rank : 320)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	288	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

PGFRB_HUMAN
NC score	0.096645 (rank : 321)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	288	Target Neighborhood Hits	962	Shared Neighborhood Hits	44
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

DDR2_MOUSE
NC score	0.096598 (rank : 322)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	288	Target Neighborhood Hits	813	Shared Neighborhood Hits	44
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA1_MOUSE
NC score	0.096592 (rank : 323)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	288	Target Neighborhood Hits	958	Shared Neighborhood Hits	45
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PGFRA_HUMAN
NC score	0.096578 (rank : 324)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	48
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

MET_MOUSE
NC score	0.096512 (rank : 325)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	288	Target Neighborhood Hits	844	Shared Neighborhood Hits	44
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

KIT_MOUSE
NC score	0.096499 (rank : 326)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	45
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

UFO_HUMAN
NC score	0.096377 (rank : 327)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	288	Target Neighborhood Hits	981	Shared Neighborhood Hits	44
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHA1_HUMAN
NC score	0.096242 (rank : 328)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	288	Target Neighborhood Hits	997	Shared Neighborhood Hits	45
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

AMPH_HUMAN
NC score	0.096235 (rank : 329)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	288	Target Neighborhood Hits	455	Shared Neighborhood Hits	83
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

EGFR_MOUSE
NC score	0.096203 (rank : 330)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	288	Target Neighborhood Hits	927	Shared Neighborhood Hits	46
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EGFR_HUMAN
NC score	0.096162 (rank : 331)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	288	Target Neighborhood Hits	939	Shared Neighborhood Hits	46
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

MET_HUMAN
NC score	0.095924 (rank : 332)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	288	Target Neighborhood Hits	831	Shared Neighborhood Hits	44
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RET_HUMAN
NC score	0.095924 (rank : 333)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	44
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

UFO_MOUSE
NC score	0.095778 (rank : 334)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ROR2_HUMAN
NC score	0.095626 (rank : 335)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	288	Target Neighborhood Hits	1014	Shared Neighborhood Hits	45
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

KIT_HUMAN
NC score	0.095408 (rank : 336)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	288	Target Neighborhood Hits	953	Shared Neighborhood Hits	44
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CSF1R_MOUSE
NC score	0.095378 (rank : 337)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	288	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHA2_MOUSE
NC score	0.095232 (rank : 338)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	288	Target Neighborhood Hits	1020	Shared Neighborhood Hits	46
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

RET_MOUSE
NC score	0.095092 (rank : 339)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	288	Target Neighborhood Hits	884	Shared Neighborhood Hits	44
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHA2_HUMAN
NC score	0.095024 (rank : 340)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	288	Target Neighborhood Hits	1021	Shared Neighborhood Hits	46
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ROR1_MOUSE
NC score	0.094638 (rank : 341)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

EPHB3_MOUSE
NC score	0.094532 (rank : 342)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	288	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB3_HUMAN
NC score	0.094326 (rank : 343)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	288	Target Neighborhood Hits	996	Shared Neighborhood Hits	48
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

SHLB1_HUMAN
NC score	0.094261 (rank : 344)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	288	Target Neighborhood Hits	96	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

EPHB4_HUMAN
NC score	0.094238 (rank : 345)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	288	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ROR1_HUMAN
NC score	0.094210 (rank : 346)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	288	Target Neighborhood Hits	1018	Shared Neighborhood Hits	44
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

FGFR4_MOUSE
NC score	0.093993 (rank : 347)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA8_MOUSE
NC score	0.093986 (rank : 348)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	288	Target Neighborhood Hits	969	Shared Neighborhood Hits	45
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB4_MOUSE
NC score	0.093831 (rank : 349)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	288	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA8_HUMAN
NC score	0.093828 (rank : 350)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	288	Target Neighborhood Hits	956	Shared Neighborhood Hits	44
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB2_MOUSE
NC score	0.093659 (rank : 351)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	288	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.093633 (rank : 352)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	288	Target Neighborhood Hits	983	Shared Neighborhood Hits	44
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA4_HUMAN
NC score	0.093502 (rank : 353)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	288	Target Neighborhood Hits	975	Shared Neighborhood Hits	44
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.093458 (rank : 354)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	288	Target Neighborhood Hits	982	Shared Neighborhood Hits	44
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

TYRO3_MOUSE
NC score	0.093312 (rank : 355)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	45
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ARHGG_MOUSE
NC score	0.093157 (rank : 356)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	288	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NTRK2_MOUSE
NC score	0.092948 (rank : 357)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	44
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.092946 (rank : 358)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	288	Target Neighborhood Hits	1081	Shared Neighborhood Hits	44
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

EPHA5_HUMAN
NC score	0.092893 (rank : 359)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	46
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

TYRO3_HUMAN
NC score	0.092750 (rank : 360)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	288	Target Neighborhood Hits	995	Shared Neighborhood Hits	43
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHB1_HUMAN
NC score	0.092663 (rank : 361)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	288	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TRIO_HUMAN
NC score	0.092532 (rank : 362)	θ value	0.0330416 (rank : 88)
Query Neighborhood Hits	288	Target Neighborhood Hits	1580	Shared Neighborhood Hits	132
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ILK_MOUSE
NC score	0.092297 (rank : 363)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	47
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

FGFR4_HUMAN
NC score	0.092253 (rank : 364)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	288	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

EPHA3_MOUSE
NC score	0.092149 (rank : 365)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	288	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA3_HUMAN
NC score	0.092060 (rank : 366)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

SHLB2_MOUSE
NC score	0.091664 (rank : 367)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	288	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ILK1_HUMAN
NC score	0.091600 (rank : 368)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	288	Target Neighborhood Hits	857	Shared Neighborhood Hits	47
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

EPHA7_MOUSE
NC score	0.091526 (rank : 369)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	46
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

GUC2F_HUMAN
NC score	0.091417 (rank : 370)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	288	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

EPHA7_HUMAN
NC score	0.091390 (rank : 371)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	288	Target Neighborhood Hits	1053	Shared Neighborhood Hits	46
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

TIE1_HUMAN
NC score	0.090675 (rank : 372)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	288	Target Neighborhood Hits	1241	Shared Neighborhood Hits	45
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ILK2_HUMAN
NC score	0.090607 (rank : 373)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MLKL_HUMAN
NC score	0.090468 (rank : 374)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	288	Target Neighborhood Hits	600	Shared Neighborhood Hits	46
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TIE1_MOUSE
NC score	0.090435 (rank : 375)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	288	Target Neighborhood Hits	1266	Shared Neighborhood Hits	46
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
NC score	0.090329 (rank : 376)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	288	Target Neighborhood Hits	1192	Shared Neighborhood Hits	46
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

MUSK_MOUSE
NC score	0.090263 (rank : 377)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	288	Target Neighborhood Hits	1057	Shared Neighborhood Hits	44
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

TIE2_MOUSE
NC score	0.090206 (rank : 378)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	288	Target Neighborhood Hits	1204	Shared Neighborhood Hits	46
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

FGFR3_HUMAN
NC score	0.090107 (rank : 379)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	288	Target Neighborhood Hits	1042	Shared Neighborhood Hits	44
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

BCAR3_HUMAN
NC score	0.090064 (rank : 380)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	288	Target Neighborhood Hits	129	Shared Neighborhood Hits	42
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

MUSK_HUMAN
NC score	0.089987 (rank : 381)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	288	Target Neighborhood Hits	1074	Shared Neighborhood Hits	44
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

FGFR2_MOUSE
NC score	0.089688 (rank : 382)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	288	Target Neighborhood Hits	1062	Shared Neighborhood Hits	44
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_MOUSE
NC score	0.089636 (rank : 383)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	44
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR2_HUMAN
NC score	0.089245 (rank : 384)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	288	Target Neighborhood Hits	1062	Shared Neighborhood Hits	44
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

VGFR3_MOUSE
NC score	0.089224 (rank : 385)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	288	Target Neighborhood Hits	1056	Shared Neighborhood Hits	44
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

SHLB2_HUMAN
NC score	0.089109 (rank : 386)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	288	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLY_HUMAN
NC score	0.089054 (rank : 387)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	288	Target Neighborhood Hits	81	Shared Neighborhood Hits	46
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

DOCK1_HUMAN
NC score	0.088878 (rank : 388)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	288	Target Neighborhood Hits	191	Shared Neighborhood Hits	96
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SEC63_HUMAN
NC score	0.088857 (rank : 389)	θ value	0.00102713 (rank : 39)
Query Neighborhood Hits	288	Target Neighborhood Hits	586	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

VGFR3_HUMAN
NC score	0.088799 (rank : 390)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	288	Target Neighborhood Hits	1037	Shared Neighborhood Hits	44
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.088658 (rank : 391)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	288	Target Neighborhood Hits	1068	Shared Neighborhood Hits	44
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.088647 (rank : 392)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	288	Target Neighborhood Hits	1069	Shared Neighborhood Hits	44
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

SH24A_MOUSE
NC score	0.088505 (rank : 393)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	288	Target Neighborhood Hits	326	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

LCP2_HUMAN
NC score	0.088282 (rank : 394)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	288	Target Neighborhood Hits	531	Shared Neighborhood Hits	49
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

FYB_MOUSE
NC score	0.088183 (rank : 395)	θ value	1.06291 (rank : 171)
Query Neighborhood Hits	288	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PTK7_HUMAN
NC score	0.088173 (rank : 396)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	46
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

STS2_HUMAN
NC score	0.088106 (rank : 397)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	288	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

JAK1_MOUSE
NC score	0.088006 (rank : 398)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	288	Target Neighborhood Hits	854	Shared Neighborhood Hits	45
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

HSH2D_MOUSE
NC score	0.087943 (rank : 399)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	288	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

JAK1_HUMAN
NC score	0.087922 (rank : 400)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	46
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

BCAR3_MOUSE
NC score	0.087612 (rank : 401)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	288	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ANPRA_MOUSE
NC score	0.087547 (rank : 402)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	288	Target Neighborhood Hits	600	Shared Neighborhood Hits	42
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

PTN6_MOUSE
NC score	0.087526 (rank : 403)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

ANPRA_HUMAN
NC score	0.087405 (rank : 404)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	288	Target Neighborhood Hits	612	Shared Neighborhood Hits	40
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

MLKL_MOUSE
NC score	0.087355 (rank : 405)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	288	Target Neighborhood Hits	707	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

CHIN_MOUSE
NC score	0.087198 (rank : 406)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	288	Target Neighborhood Hits	229	Shared Neighborhood Hits	52
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

TYK2_MOUSE
NC score	0.087163 (rank : 407)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

SEC63_MOUSE
NC score	0.087084 (rank : 408)	θ value	0.00509761 (rank : 55)
Query Neighborhood Hits	288	Target Neighborhood Hits	601	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

GUC2C_HUMAN
NC score	0.086997 (rank : 409)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	288	Target Neighborhood Hits	624	Shared Neighborhood Hits	40
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

JAK3_HUMAN
NC score	0.086637 (rank : 410)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	288	Target Neighborhood Hits	827	Shared Neighborhood Hits	44
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

SH22A_HUMAN
NC score	0.086410 (rank : 411)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	288	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

VGFR2_MOUSE
NC score	0.086240 (rank : 412)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	288	Target Neighborhood Hits	1089	Shared Neighborhood Hits	44
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

PTN6_HUMAN
NC score	0.086106 (rank : 413)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	288	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

TYK2_HUMAN
NC score	0.086038 (rank : 414)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	288	Target Neighborhood Hits	841	Shared Neighborhood Hits	44
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

VGFR2_HUMAN
NC score	0.085930 (rank : 415)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	288	Target Neighborhood Hits	1103	Shared Neighborhood Hits	44
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

IRAK3_MOUSE
NC score	0.085445 (rank : 416)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	288	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ANPRB_MOUSE
NC score	0.084838 (rank : 417)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	288	Target Neighborhood Hits	607	Shared Neighborhood Hits	42
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_MOUSE
NC score	0.084673 (rank : 418)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	49
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

MACOI_HUMAN
NC score	0.084666 (rank : 419)	θ value	0.163984 (rank : 131)
Query Neighborhood Hits	288	Target Neighborhood Hits	650	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

BIN1_MOUSE
NC score	0.084657 (rank : 420)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	288	Target Neighborhood Hits	283	Shared Neighborhood Hits	75
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

GUC2G_MOUSE
NC score	0.084569 (rank : 421)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	288	Target Neighborhood Hits	644	Shared Neighborhood Hits	41
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

RAF1_HUMAN
NC score	0.084532 (rank : 422)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

VGFR1_HUMAN
NC score	0.084528 (rank : 423)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	288	Target Neighborhood Hits	1109	Shared Neighborhood Hits	44
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ANPRB_HUMAN
NC score	0.084277 (rank : 424)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	288	Target Neighborhood Hits	646	Shared Neighborhood Hits	42
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

VGFR1_MOUSE
NC score	0.084211 (rank : 425)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	288	Target Neighborhood Hits	1118	Shared Neighborhood Hits	44
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

STS1_HUMAN
NC score	0.084156 (rank : 426)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	288	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

MLTK_HUMAN
NC score	0.084142 (rank : 427)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

BRAF1_HUMAN
NC score	0.084136 (rank : 428)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	288	Target Neighborhood Hits	883	Shared Neighborhood Hits	50
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CHIN_HUMAN
NC score	0.084096 (rank : 429)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.084088 (rank : 430)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	288	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

ARAF_HUMAN
NC score	0.084062 (rank : 431)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	288	Target Neighborhood Hits	924	Shared Neighborhood Hits	50
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RAF1_MOUSE
NC score	0.084049 (rank : 432)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MLTK_MOUSE
NC score	0.084033 (rank : 433)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

JAK2_MOUSE
NC score	0.084018 (rank : 434)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	288	Target Neighborhood Hits	839	Shared Neighborhood Hits	45
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_MOUSE
NC score	0.083874 (rank : 435)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	288	Target Neighborhood Hits	821	Shared Neighborhood Hits	44
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JAK2_HUMAN
NC score	0.083668 (rank : 436)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

SM1L2_HUMAN
NC score	0.083585 (rank : 437)	θ value	0.0563607 (rank : 97)
Query Neighborhood Hits	288	Target Neighborhood Hits	1019	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SH23A_HUMAN
NC score	0.083244 (rank : 438)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	288	Target Neighborhood Hits	149	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

HAPIP_HUMAN
NC score	0.083123 (rank : 439)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	288	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MOS_HUMAN
NC score	0.082832 (rank : 440)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	288	Target Neighborhood Hits	829	Shared Neighborhood Hits	44
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

AMPH_MOUSE
NC score	0.082130 (rank : 441)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	74
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

MOS_MOUSE
NC score	0.082021 (rank : 442)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

GUC2D_HUMAN
NC score	0.082019 (rank : 443)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

STS1_MOUSE
NC score	0.081843 (rank : 444)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	288	Target Neighborhood Hits	104	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

MACOI_MOUSE
NC score	0.081711 (rank : 445)	θ value	0.365318 (rank : 143)
Query Neighborhood Hits	288	Target Neighborhood Hits	620	Shared Neighborhood Hits	63
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

BIN1_HUMAN
NC score	0.081413 (rank : 446)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	288	Target Neighborhood Hits	335	Shared Neighborhood Hits	68
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

GUC2E_MOUSE
NC score	0.081298 (rank : 447)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	288	Target Neighborhood Hits	692	Shared Neighborhood Hits	40
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

BMR1B_MOUSE
NC score	0.080713 (rank : 448)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	288	Target Neighborhood Hits	758	Shared Neighborhood Hits	41
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.080514 (rank : 449)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	288	Target Neighborhood Hits	760	Shared Neighborhood Hits	41
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

ARHG3_HUMAN
NC score	0.080374 (rank : 450)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	288	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

RIPK1_MOUSE
NC score	0.080197 (rank : 451)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	45
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ARHGG_HUMAN
NC score	0.080105 (rank : 452)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	288	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_MOUSE
NC score	0.079907 (rank : 453)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	288	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

KSR2_HUMAN
NC score	0.079856 (rank : 454)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	288	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RHG12_MOUSE
NC score	0.079821 (rank : 455)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

IRAK3_HUMAN
NC score	0.079544 (rank : 456)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	288	Target Neighborhood Hits	644	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK1_HUMAN
NC score	0.079519 (rank : 457)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	288	Target Neighborhood Hits	891	Shared Neighborhood Hits	45
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

KSR1_HUMAN
NC score	0.079343 (rank : 458)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TENS4_MOUSE
NC score	0.079307 (rank : 459)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

M3K13_HUMAN
NC score	0.078578 (rank : 460)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	45
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K12_HUMAN
NC score	0.078520 (rank : 461)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	288	Target Neighborhood Hits	940	Shared Neighborhood Hits	47
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

IRAK1_MOUSE
NC score	0.078505 (rank : 462)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	288	Target Neighborhood Hits	784	Shared Neighborhood Hits	42
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

M3K12_MOUSE
NC score	0.078417 (rank : 463)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	288	Target Neighborhood Hits	957	Shared Neighborhood Hits	46
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

BMR1A_MOUSE
NC score	0.078388 (rank : 464)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	288	Target Neighborhood Hits	758	Shared Neighborhood Hits	44
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

KSR1_MOUSE
NC score	0.078212 (rank : 465)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	288	Target Neighborhood Hits	870	Shared Neighborhood Hits	45
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

BMR1A_HUMAN
NC score	0.078208 (rank : 466)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	288	Target Neighborhood Hits	759	Shared Neighborhood Hits	45
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

ARHG8_MOUSE
NC score	0.077712 (rank : 467)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	288	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

M3K7_MOUSE
NC score	0.077613 (rank : 468)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	288	Target Neighborhood Hits	892	Shared Neighborhood Hits	56
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.077517 (rank : 469)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	288	Target Neighborhood Hits	892	Shared Neighborhood Hits	55
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TIAM1_MOUSE
NC score	0.077129 (rank : 470)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	288	Target Neighborhood Hits	205	Shared Neighborhood Hits	29
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHG1_HUMAN
NC score	0.077029 (rank : 471)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	288	Target Neighborhood Hits	174	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RIPK3_MOUSE
NC score	0.076744 (rank : 472)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK2_MOUSE
NC score	0.076688 (rank : 473)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	288	Target Neighborhood Hits	776	Shared Neighborhood Hits	44
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RHG12_HUMAN
NC score	0.076479 (rank : 474)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	288	Target Neighborhood Hits	190	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DLG2_MOUSE
NC score	0.076307 (rank : 475)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	288	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

ARHG8_HUMAN
NC score	0.076120 (rank : 476)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	288	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

RIPK2_HUMAN
NC score	0.076058 (rank : 477)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	288	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TIAM1_HUMAN
NC score	0.075930 (rank : 478)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	288	Target Neighborhood Hits	225	Shared Neighborhood Hits	29
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

BLNK_MOUSE
NC score	0.075880 (rank : 479)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	288	Target Neighborhood Hits	296	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

SOCS6_MOUSE
NC score	0.075781 (rank : 480)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	288	Target Neighborhood Hits	146	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

IRAK4_HUMAN
NC score	0.075715 (rank : 481)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	288	Target Neighborhood Hits	816	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

RIPK3_HUMAN
NC score	0.075548 (rank : 482)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

SOCS6_HUMAN
NC score	0.075109 (rank : 483)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	288	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

CP250_MOUSE
NC score	0.075000 (rank : 484)	θ value	1.06291 (rank : 170)
Query Neighborhood Hits	288	Target Neighborhood Hits	1583	Shared Neighborhood Hits	98
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

IRAK2_HUMAN
NC score	0.074907 (rank : 485)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	288	Target Neighborhood Hits	714	Shared Neighborhood Hits	43
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IFT81_MOUSE
NC score	0.074865 (rank : 486)	θ value	3.0926 (rank : 217)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	77
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CP250_HUMAN
NC score	0.074449 (rank : 487)	θ value	0.813845 (rank : 165)
Query Neighborhood Hits	288	Target Neighborhood Hits	1805	Shared Neighborhood Hits	102
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

EEA1_HUMAN
NC score	0.074270 (rank : 488)	θ value	0.0961366 (rank : 109)
Query Neighborhood Hits	288	Target Neighborhood Hits	1796	Shared Neighborhood Hits	102
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

BLNK_HUMAN
NC score	0.074214 (rank : 489)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	288	Target Neighborhood Hits	228	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DLG5_HUMAN
NC score	0.074161 (rank : 490)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	103
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

SOCS2_MOUSE
NC score	0.074084 (rank : 491)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

IRAK1_HUMAN
NC score	0.073915 (rank : 492)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

PREX1_HUMAN
NC score	0.073889 (rank : 493)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	288	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CCD19_HUMAN
NC score	0.073735 (rank : 494)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	288	Target Neighborhood Hits	639	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

RUSC2_MOUSE
NC score	0.073603 (rank : 495)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	288	Target Neighborhood Hits	305	Shared Neighborhood Hits	59
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CE290_HUMAN
NC score	0.073503 (rank : 496)	θ value	0.62314 (rank : 157)
Query Neighborhood Hits	288	Target Neighborhood Hits	1553	Shared Neighborhood Hits	96
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CSKP_HUMAN
NC score	0.073492 (rank : 497)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	288	Target Neighborhood Hits	1022	Shared Neighborhood Hits	114
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

ACVL1_HUMAN
NC score	0.073416 (rank : 498)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	288	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
NC score	0.073386 (rank : 499)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	288	Target Neighborhood Hits	739	Shared Neighborhood Hits	43
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

GOGB1_HUMAN
NC score	0.073289 (rank : 500)	θ value	0.62314 (rank : 159)
Query Neighborhood Hits	288	Target Neighborhood Hits	2297	Shared Neighborhood Hits	111
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

IRAK4_MOUSE
NC score	0.073032 (rank : 501)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ACV1C_MOUSE
NC score	0.072775 (rank : 502)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CSKP_MOUSE
NC score	0.072601 (rank : 503)	θ value	5.27518 (rank : 239)
Query Neighborhood Hits	288	Target Neighborhood Hits	1027	Shared Neighborhood Hits	119
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

ACV1C_HUMAN
NC score	0.072591 (rank : 504)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	288	Target Neighborhood Hits	709	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ARHGA_HUMAN
NC score	0.072568 (rank : 505)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	288	Target Neighborhood Hits	187	Shared Neighborhood Hits	33
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

TRHY_HUMAN
NC score	0.072540 (rank : 506)	θ value	0.125558 (rank : 124)
Query Neighborhood Hits	288	Target Neighborhood Hits	1385	Shared Neighborhood Hits	99
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

LIMK1_MOUSE
NC score	0.072443 (rank : 507)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	288	Target Neighborhood Hits	1008	Shared Neighborhood Hits	49
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

TESK2_HUMAN
NC score	0.072313 (rank : 508)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	45
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LIMK1_HUMAN
NC score	0.072307 (rank : 509)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	48
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

BI2L1_HUMAN
NC score	0.072104 (rank : 510)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	288	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TGFR1_HUMAN
NC score	0.071954 (rank : 511)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	288	Target Neighborhood Hits	755	Shared Neighborhood Hits	44
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

CISH_HUMAN
NC score	0.071919 (rank : 512)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

ARHGA_MOUSE
NC score	0.071910 (rank : 513)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	288	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

TGFR1_MOUSE
NC score	0.071862 (rank : 514)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TESK2_MOUSE
NC score	0.071444 (rank : 515)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ACV1B_HUMAN
NC score	0.071393 (rank : 516)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
NC score	0.071370 (rank : 517)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	44
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

TOPK_MOUSE
NC score	0.071314 (rank : 518)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	288	Target Neighborhood Hits	618	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TAOK1_HUMAN
NC score	0.071280 (rank : 519)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	288	Target Neighborhood Hits	1734	Shared Neighborhood Hits	112
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
NC score	0.071276 (rank : 520)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	288	Target Neighborhood Hits	1720	Shared Neighborhood Hits	113
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

MYH10_MOUSE
NC score	0.071274 (rank : 521)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	288	Target Neighborhood Hits	1612	Shared Neighborhood Hits	108
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MCF2_HUMAN
NC score	0.071244 (rank : 522)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	35
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TENS4_HUMAN
NC score	0.071167 (rank : 523)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	288	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TOPK_HUMAN
NC score	0.071103 (rank : 524)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	288	Target Neighborhood Hits	605	Shared Neighborhood Hits	42
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TNI3K_MOUSE
NC score	0.071067 (rank : 525)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	288	Target Neighborhood Hits	1079	Shared Neighborhood Hits	49
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

BCR_HUMAN
NC score	0.070998 (rank : 526)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	288	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

TNI3K_HUMAN
NC score	0.070827 (rank : 527)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	288	Target Neighborhood Hits	1084	Shared Neighborhood Hits	49
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CISH_MOUSE
NC score	0.070476 (rank : 528)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

RIPK5_MOUSE
NC score	0.070349 (rank : 529)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

INVO_HUMAN
NC score	0.070343 (rank : 530)	θ value	1.06291 (rank : 173)
Query Neighborhood Hits	288	Target Neighborhood Hits	636	Shared Neighborhood Hits	58
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

RIPK5_HUMAN
NC score	0.070293 (rank : 531)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	46
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

EEA1_MOUSE
NC score	0.070140 (rank : 532)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	288	Target Neighborhood Hits	1637	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYH10_HUMAN
NC score	0.070088 (rank : 533)	θ value	1.38821 (rank : 181)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	108
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RHG09_HUMAN
NC score	0.070075 (rank : 534)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	288	Target Neighborhood Hits	186	Shared Neighborhood Hits	42
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

TAOK2_MOUSE
NC score	0.069944 (rank : 535)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	288	Target Neighborhood Hits	1373	Shared Neighborhood Hits	109
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TESK1_MOUSE
NC score	0.069841 (rank : 536)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	288	Target Neighborhood Hits	862	Shared Neighborhood Hits	44
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_HUMAN
NC score	0.069808 (rank : 537)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

SM1L2_MOUSE
NC score	0.069795 (rank : 538)	θ value	5.27518 (rank : 249)
Query Neighborhood Hits	288	Target Neighborhood Hits	918	Shared Neighborhood Hits	78
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

M4K4_HUMAN
NC score	0.069602 (rank : 539)	θ value	0.0961366 (rank : 113)
Query Neighborhood Hits	288	Target Neighborhood Hits	1589	Shared Neighborhood Hits	111
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
NC score	0.069570 (rank : 540)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	288	Target Neighborhood Hits	1560	Shared Neighborhood Hits	107
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

LIMK2_HUMAN
NC score	0.069477 (rank : 541)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	288	Target Neighborhood Hits	986	Shared Neighborhood Hits	48
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

GOGA4_MOUSE
NC score	0.069469 (rank : 542)	θ value	2.36792 (rank : 206)
Query Neighborhood Hits	288	Target Neighborhood Hits	1939	Shared Neighborhood Hits	105
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

AKAP9_HUMAN
NC score	0.069394 (rank : 543)	θ value	2.36792 (rank : 198)
Query Neighborhood Hits	288	Target Neighborhood Hits	1710	Shared Neighborhood Hits	96
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

STK10_MOUSE
NC score	0.069373 (rank : 544)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	288	Target Neighborhood Hits	2132	Shared Neighborhood Hits	131
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CENPF_HUMAN
NC score	0.069340 (rank : 545)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	288	Target Neighborhood Hits	1932	Shared Neighborhood Hits	110
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

LIMK2_MOUSE
NC score	0.069257 (rank : 546)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	288	Target Neighborhood Hits	998	Shared Neighborhood Hits	48
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MYH13_HUMAN
NC score	0.069246 (rank : 547)	θ value	1.81305 (rank : 192)
Query Neighborhood Hits	288	Target Neighborhood Hits	1504	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

GCC2_MOUSE
NC score	0.069014 (rank : 548)	θ value	0.62314 (rank : 158)
Query Neighborhood Hits	288	Target Neighborhood Hits	1619	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GCC2_HUMAN
NC score	0.069007 (rank : 549)	θ value	3.0926 (rank : 214)
Query Neighborhood Hits	288	Target Neighborhood Hits	1558	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

DLG2_HUMAN
NC score	0.069007 (rank : 550)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	288	Target Neighborhood Hits	279	Shared Neighborhood Hits	72
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MYH3_HUMAN
NC score	0.069004 (rank : 551)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	288	Target Neighborhood Hits	1660	Shared Neighborhood Hits	112
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

RBP24_HUMAN
NC score	0.068915 (rank : 552)	θ value	3.0926 (rank : 223)
Query Neighborhood Hits	288	Target Neighborhood Hits	1559	Shared Neighborhood Hits	98
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

DLG4_HUMAN
NC score	0.068679 (rank : 553)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	288	Target Neighborhood Hits	286	Shared Neighborhood Hits	70
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MYH1_MOUSE
NC score	0.068679 (rank : 554)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	288	Target Neighborhood Hits	1461	Shared Neighborhood Hits	107
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

RGNEF_MOUSE
NC score	0.068661 (rank : 555)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	288	Target Neighborhood Hits	641	Shared Neighborhood Hits	66
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CCHCR_HUMAN
NC score	0.068573 (rank : 556)	θ value	0.813845 (rank : 164)
Query Neighborhood Hits	288	Target Neighborhood Hits	717	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

GAS7_HUMAN
NC score	0.068544 (rank : 557)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	288	Target Neighborhood Hits	258	Shared Neighborhood Hits	44
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

DLG1_HUMAN
NC score	0.068449 (rank : 558)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	288	Target Neighborhood Hits	290	Shared Neighborhood Hits	65
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

ACVR1_MOUSE
NC score	0.068112 (rank : 559)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	288	Target Neighborhood Hits	768	Shared Neighborhood Hits	43
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

TAOK3_HUMAN
NC score	0.068064 (rank : 560)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	288	Target Neighborhood Hits	1494	Shared Neighborhood Hits	105
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

MYH8_MOUSE
NC score	0.067823 (rank : 561)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	288	Target Neighborhood Hits	1600	Shared Neighborhood Hits	105
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

ACVR1_HUMAN
NC score	0.067728 (rank : 562)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	288	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

MY18A_HUMAN
NC score	0.067506 (rank : 563)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	288	Target Neighborhood Hits	1929	Shared Neighborhood Hits	116
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

GOGA4_HUMAN
NC score	0.067246 (rank : 564)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	288	Target Neighborhood Hits	2034	Shared Neighborhood Hits	114
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SMC1A_HUMAN
NC score	0.067212 (rank : 565)	θ value	5.27518 (rank : 250)
Query Neighborhood Hits	288	Target Neighborhood Hits	1346	Shared Neighborhood Hits	87
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
NC score	0.067128 (rank : 566)	θ value	5.27518 (rank : 251)
Query Neighborhood Hits	288	Target Neighborhood Hits	1384	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SOCS2_HUMAN
NC score	0.067091 (rank : 567)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	288	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

MPP3_HUMAN
NC score	0.067067 (rank : 568)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	288	Target Neighborhood Hits	171	Shared Neighborhood Hits	33
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MYH8_HUMAN
NC score	0.067045 (rank : 569)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	288	Target Neighborhood Hits	1610	Shared Neighborhood Hits	105
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH11_HUMAN
NC score	0.067007 (rank : 570)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	288	Target Neighborhood Hits	1806	Shared Neighborhood Hits	112
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CCD91_HUMAN
NC score	0.066949 (rank : 571)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	288	Target Neighborhood Hits	868	Shared Neighborhood Hits	74
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

STK10_HUMAN
NC score	0.066916 (rank : 572)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	288	Target Neighborhood Hits	1921	Shared Neighborhood Hits	116
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MPP3_MOUSE
NC score	0.066695 (rank : 573)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	288	Target Neighborhood Hits	165	Shared Neighborhood Hits	31
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MRCKB_MOUSE
NC score	0.066657 (rank : 574)	θ value	4.03905 (rank : 230)
Query Neighborhood Hits	288	Target Neighborhood Hits	2180	Shared Neighborhood Hits	137
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

CCD46_HUMAN
NC score	0.066481 (rank : 575)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	288	Target Neighborhood Hits	1430	Shared Neighborhood Hits	97
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

MY18A_MOUSE
NC score	0.066274 (rank : 576)	θ value	1.38821 (rank : 180)
Query Neighborhood Hits	288	Target Neighborhood Hits	1989	Shared Neighborhood Hits	113
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TAOK3_MOUSE
NC score	0.066251 (rank : 577)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	288	Target Neighborhood Hits	1458	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CEP63_HUMAN
NC score	0.066222 (rank : 578)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	288	Target Neighborhood Hits	1005	Shared Neighborhood Hits	83
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CTRO_MOUSE
NC score	0.066216 (rank : 579)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	288	Target Neighborhood Hits	2344	Shared Neighborhood Hits	135
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MYH6_MOUSE
NC score	0.066159 (rank : 580)	θ value	8.99809 (rank : 282)
Query Neighborhood Hits	288	Target Neighborhood Hits	1501	Shared Neighborhood Hits	102
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

DLG1_MOUSE
NC score	0.066101 (rank : 581)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	288	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DESP_HUMAN
NC score	0.065877 (rank : 582)	θ value	2.36792 (rank : 205)
Query Neighborhood Hits	288	Target Neighborhood Hits	1470	Shared Neighborhood Hits	90
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

MYH1_HUMAN
NC score	0.065876 (rank : 583)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	288	Target Neighborhood Hits	1478	Shared Neighborhood Hits	104
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

CI093_HUMAN
NC score	0.065816 (rank : 584)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	83
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

MYH11_MOUSE
NC score	0.065799 (rank : 585)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	288	Target Neighborhood Hits	1777	Shared Neighborhood Hits	110
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

AMHR2_HUMAN
NC score	0.065651 (rank : 586)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	288	Target Neighborhood Hits	715	Shared Neighborhood Hits	41
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
NC score	0.065600 (rank : 587)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	288	Target Neighborhood Hits	1075	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

MYH9_HUMAN
NC score	0.065566 (rank : 588)	θ value	6.88961 (rank : 263)
Query Neighborhood Hits	288	Target Neighborhood Hits	1762	Shared Neighborhood Hits	116
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

ANKK1_MOUSE
NC score	0.065482 (rank : 589)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	288	Target Neighborhood Hits	1072	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

CE152_HUMAN
NC score	0.065443 (rank : 590)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	288	Target Neighborhood Hits	976	Shared Neighborhood Hits	79
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

GAS7_MOUSE
NC score	0.065419 (rank : 591)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	288	Target Neighborhood Hits	259	Shared Neighborhood Hits	43
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

EP15R_MOUSE
NC score	0.065414 (rank : 592)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	81
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

TPR_HUMAN
NC score	0.065310 (rank : 593)	θ value	1.81305 (rank : 197)
Query Neighborhood Hits	288	Target Neighborhood Hits	1921	Shared Neighborhood Hits	102
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

MYH4_MOUSE
NC score	0.065244 (rank : 594)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	288	Target Neighborhood Hits	1476	Shared Neighborhood Hits	102
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

EP15R_HUMAN
NC score	0.065162 (rank : 595)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	288	Target Neighborhood Hits	1083	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15_MOUSE
NC score	0.065135 (rank : 596)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	70
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MYH2_HUMAN
NC score	0.065112 (rank : 597)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	288	Target Neighborhood Hits	1491	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

PIBF1_HUMAN
NC score	0.065006 (rank : 598)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	288	Target Neighborhood Hits	1041	Shared Neighborhood Hits	79
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

CCD46_MOUSE
NC score	0.064959 (rank : 599)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	98
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

TTBK1_HUMAN
NC score	0.064821 (rank : 600)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	288	Target Neighborhood Hits	1058	Shared Neighborhood Hits	60
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

CTRO_HUMAN
NC score	0.064754 (rank : 601)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	288	Target Neighborhood Hits	2092	Shared Neighborhood Hits	124
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GOGA3_MOUSE
NC score	0.064635 (rank : 602)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	288	Target Neighborhood Hits	1437	Shared Neighborhood Hits	90
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

HIP1R_MOUSE
NC score	0.064619 (rank : 603)	θ value	0.279714 (rank : 136)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

DMD_MOUSE
NC score	0.064513 (rank : 604)	θ value	4.03905 (rank : 228)
Query Neighborhood Hits	288	Target Neighborhood Hits	1111	Shared Neighborhood Hits	90
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

MYH7_HUMAN
NC score	0.064480 (rank : 605)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	288	Target Neighborhood Hits	1559	Shared Neighborhood Hits	98
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MRCKB_HUMAN
NC score	0.064429 (rank : 606)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	288	Target Neighborhood Hits	2239	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

BRE1B_HUMAN
NC score	0.064273 (rank : 607)	θ value	2.36792 (rank : 199)
Query Neighborhood Hits	288	Target Neighborhood Hits	1040	Shared Neighborhood Hits	71
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

PCNT_HUMAN
NC score	0.064003 (rank : 608)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	288	Target Neighborhood Hits	1551	Shared Neighborhood Hits	103
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

IFT81_HUMAN
NC score	0.063983 (rank : 609)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

EP15_HUMAN
NC score	0.063953 (rank : 610)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	288	Target Neighborhood Hits	1021	Shared Neighborhood Hits	77
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

NEK11_HUMAN
NC score	0.063914 (rank : 611)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	288	Target Neighborhood Hits	1043	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TNIK_HUMAN
NC score	0.063825 (rank : 612)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	288	Target Neighborhood Hits	1570	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

SASH1_HUMAN
NC score	0.063770 (rank : 613)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	288	Target Neighborhood Hits	292	Shared Neighborhood Hits	50
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

BPAEA_MOUSE
NC score	0.063709 (rank : 614)	θ value	3.0926 (rank : 213)
Query Neighborhood Hits	288	Target Neighborhood Hits	1480	Shared Neighborhood Hits	91
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MINK1_HUMAN
NC score	0.063701 (rank : 615)	θ value	6.88961 (rank : 261)
Query Neighborhood Hits	288	Target Neighborhood Hits	1477	Shared Neighborhood Hits	104
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

DLG4_MOUSE
NC score	0.063687 (rank : 616)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	288	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

RIPK4_HUMAN
NC score	0.063648 (rank : 617)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	288	Target Neighborhood Hits	1094	Shared Neighborhood Hits	49
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

DMD_HUMAN
NC score	0.063640 (rank : 618)	θ value	5.27518 (rank : 240)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	90
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

NUMA1_HUMAN
NC score	0.063608 (rank : 619)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	288	Target Neighborhood Hits	1523	Shared Neighborhood Hits	94
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

MINK1_MOUSE
NC score	0.063560 (rank : 620)	θ value	6.88961 (rank : 262)
Query Neighborhood Hits	288	Target Neighborhood Hits	1451	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYH9_MOUSE
NC score	0.063549 (rank : 621)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	288	Target Neighborhood Hits	1829	Shared Neighborhood Hits	110
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CI096_HUMAN
NC score	0.063540 (rank : 622)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	288	Target Neighborhood Hits	821	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

ARHG1_HUMAN
NC score	0.063538 (rank : 623)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	288	Target Neighborhood Hits	176	Shared Neighborhood Hits	21
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SLK_HUMAN
NC score	0.063517 (rank : 624)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	288	Target Neighborhood Hits	1775	Shared Neighborhood Hits	118
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

TRIPB_HUMAN
NC score	0.063449 (rank : 625)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	288	Target Neighborhood Hits	1587	Shared Neighborhood Hits	98
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ARHGB_HUMAN
NC score	0.063437 (rank : 626)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	288	Target Neighborhood Hits	375	Shared Neighborhood Hits	34
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DLG3_HUMAN
NC score	0.063391 (rank : 627)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

TAOK2_HUMAN
NC score	0.063277 (rank : 628)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	288	Target Neighborhood Hits	1172	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

ARHGC_HUMAN
NC score	0.063262 (rank : 629)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	288	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LRRK2_HUMAN
NC score	0.062899 (rank : 630)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	288	Target Neighborhood Hits	1382	Shared Neighborhood Hits	48
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

CING_MOUSE
NC score	0.062865 (rank : 631)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	288	Target Neighborhood Hits	1432	Shared Neighborhood Hits	87
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

MYH4_HUMAN
NC score	0.062864 (rank : 632)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	288	Target Neighborhood Hits	1377	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

SLK_MOUSE
NC score	0.062846 (rank : 633)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	288	Target Neighborhood Hits	1798	Shared Neighborhood Hits	123
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

LRRK2_MOUSE
NC score	0.062816 (rank : 634)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	288	Target Neighborhood Hits	1359	Shared Neighborhood Hits	48
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

CENPE_HUMAN
NC score	0.062723 (rank : 635)	θ value	2.36792 (rank : 201)
Query Neighborhood Hits	288	Target Neighborhood Hits	2060	Shared Neighborhood Hits	107
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

AZI1_HUMAN
NC score	0.062652 (rank : 636)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	288	Target Neighborhood Hits	1000	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

DLG3_MOUSE
NC score	0.062608 (rank : 637)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	288	Target Neighborhood Hits	274	Shared Neighborhood Hits	63
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

REST_HUMAN
NC score	0.062304 (rank : 638)	θ value	4.03905 (rank : 234)
Query Neighborhood Hits	288	Target Neighborhood Hits	1605	Shared Neighborhood Hits	96
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

BAIP2_MOUSE
NC score	0.062294 (rank : 639)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	288	Target Neighborhood Hits	185	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ARHGC_MOUSE
NC score	0.062286 (rank : 640)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	288	Target Neighborhood Hits	344	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MYH6_HUMAN
NC score	0.062122 (rank : 641)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	288	Target Neighborhood Hits	1426	Shared Neighborhood Hits	94
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CCD39_MOUSE
NC score	0.062031 (rank : 642)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	288	Target Neighborhood Hits	1026	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

MRCKA_HUMAN
NC score	0.061535 (rank : 643)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	288	Target Neighborhood Hits	1999	Shared Neighborhood Hits	122
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

LRRK1_MOUSE
NC score	0.061363 (rank : 644)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	288	Target Neighborhood Hits	1267	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

HMMR_HUMAN
NC score	0.061337 (rank : 645)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	288	Target Neighborhood Hits	1082	Shared Neighborhood Hits	83
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

ROCK1_MOUSE
NC score	0.061317 (rank : 646)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	288	Target Neighborhood Hits	2126	Shared Neighborhood Hits	128
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

STK39_HUMAN
NC score	0.061291 (rank : 647)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	288	Target Neighborhood Hits	882	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

SASH1_MOUSE
NC score	0.061262 (rank : 648)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	288	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

RAD50_MOUSE
NC score	0.061235 (rank : 649)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	288	Target Neighborhood Hits	1366	Shared Neighborhood Hits	85
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

HIP1R_HUMAN
NC score	0.061196 (rank : 650)	θ value	5.27518 (rank : 241)
Query Neighborhood Hits	288	Target Neighborhood Hits	809	Shared Neighborhood Hits	72
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

STK39_MOUSE
NC score	0.061149 (rank : 651)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	288	Target Neighborhood Hits	915	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

RAD50_HUMAN
NC score	0.061033 (rank : 652)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	288	Target Neighborhood Hits	1317	Shared Neighborhood Hits	83
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RABE1_HUMAN
NC score	0.060924 (rank : 653)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	288	Target Neighborhood Hits	1104	Shared Neighborhood Hits	84
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

CP135_MOUSE
NC score	0.060894 (rank : 654)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	288	Target Neighborhood Hits	1278	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

HMMR_MOUSE
NC score	0.060814 (rank : 655)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	288	Target Neighborhood Hits	1178	Shared Neighborhood Hits	89
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

ABR_HUMAN
NC score	0.060756 (rank : 656)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	288	Target Neighborhood Hits	166	Shared Neighborhood Hits	27
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

NEK11_MOUSE
NC score	0.060755 (rank : 657)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	288	Target Neighborhood Hits	875	Shared Neighborhood Hits	49
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

OXSR1_MOUSE
NC score	0.060710 (rank : 658)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	288	Target Neighborhood Hits	865	Shared Neighborhood Hits	44
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ECT2_MOUSE
NC score	0.060612 (rank : 659)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	288	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

CCHCR_MOUSE
NC score	0.060568 (rank : 660)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	288	Target Neighborhood Hits	932	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CCD41_MOUSE
NC score	0.060512 (rank : 661)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	288	Target Neighborhood Hits	1399	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

OXSR1_HUMAN
NC score	0.060448 (rank : 662)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

IFT74_HUMAN
NC score	0.060394 (rank : 663)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	78
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

GOGA1_HUMAN
NC score	0.060293 (rank : 664)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	288	Target Neighborhood Hits	1222	Shared Neighborhood Hits	85
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KMHN1_HUMAN
NC score	0.060235 (rank : 665)	θ value	2.36792 (rank : 207)
Query Neighborhood Hits	288	Target Neighborhood Hits	950	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

LRRK1_HUMAN
NC score	0.060182 (rank : 666)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	288	Target Neighborhood Hits	1237	Shared Neighborhood Hits	47
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

DUET_HUMAN
NC score	0.060071 (rank : 667)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	288	Target Neighborhood Hits	1220	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GOGA2_MOUSE
NC score	0.059970 (rank : 668)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	75
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

SYNE1_HUMAN
NC score	0.059930 (rank : 669)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	288	Target Neighborhood Hits	1484	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ROCK1_HUMAN
NC score	0.059905 (rank : 670)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	288	Target Neighborhood Hits	2000	Shared Neighborhood Hits	123
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

MYO3A_HUMAN
NC score	0.059876 (rank : 671)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	288	Target Neighborhood Hits	1033	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

BAIP2_HUMAN
NC score	0.059728 (rank : 672)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	288	Target Neighborhood Hits	192	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ROCK2_MOUSE
NC score	0.059675 (rank : 673)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	288	Target Neighborhood Hits	2072	Shared Neighborhood Hits	122
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

GOGA3_HUMAN
NC score	0.059530 (rank : 674)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	288	Target Neighborhood Hits	1317	Shared Neighborhood Hits	91
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

OPTN_MOUSE
NC score	0.059352 (rank : 675)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	288	Target Neighborhood Hits	1120	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

FLIP1_HUMAN
NC score	0.059319 (rank : 676)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	89
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CF060_HUMAN
NC score	0.059254 (rank : 677)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	288	Target Neighborhood Hits	1270	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

REST_MOUSE
NC score	0.059201 (rank : 678)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	288	Target Neighborhood Hits	1506	Shared Neighborhood Hits	92
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

CCD96_HUMAN
NC score	0.059094 (rank : 679)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	288	Target Neighborhood Hits	595	Shared Neighborhood Hits	64
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

MY18B_HUMAN
NC score	0.058988 (rank : 680)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	288	Target Neighborhood Hits	1299	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

ROCK2_HUMAN
NC score	0.058978 (rank : 681)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	288	Target Neighborhood Hits	2073	Shared Neighborhood Hits	121
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CEP55_MOUSE
NC score	0.058944 (rank : 682)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	288	Target Neighborhood Hits	693	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CASP_MOUSE
NC score	0.058918 (rank : 683)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	288	Target Neighborhood Hits	1152	Shared Neighborhood Hits	95
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

NIN_HUMAN
NC score	0.058897 (rank : 684)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	288	Target Neighborhood Hits	1416	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

CP135_HUMAN
NC score	0.058892 (rank : 685)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	288	Target Neighborhood Hits	1290	Shared Neighborhood Hits	85
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GOGA1_MOUSE
NC score	0.058847 (rank : 686)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	288	Target Neighborhood Hits	994	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

NIN_MOUSE
NC score	0.058843 (rank : 687)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	288	Target Neighborhood Hits	1376	Shared Neighborhood Hits	89
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

GRAP1_HUMAN
NC score	0.058805 (rank : 688)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	80
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

SDCG8_HUMAN
NC score	0.058770 (rank : 689)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	288	Target Neighborhood Hits	1002	Shared Neighborhood Hits	75
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

KTN1_MOUSE
NC score	0.058716 (rank : 690)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	288	Target Neighborhood Hits	1324	Shared Neighborhood Hits	87
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CCD96_MOUSE
NC score	0.058700 (rank : 691)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	288	Target Neighborhood Hits	704	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CI039_HUMAN
NC score	0.058691 (rank : 692)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	288	Target Neighborhood Hits	1171	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

MST4_HUMAN
NC score	0.058677 (rank : 693)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	288	Target Neighborhood Hits	852	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

ARHGF_HUMAN
NC score	0.058665 (rank : 694)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	288	Target Neighborhood Hits	214	Shared Neighborhood Hits	21
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

TTBK2_MOUSE
NC score	0.058616 (rank : 695)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	288	Target Neighborhood Hits	811	Shared Neighborhood Hits	44
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

STK24_MOUSE
NC score	0.058590 (rank : 696)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	44
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

MST4_MOUSE
NC score	0.058575 (rank : 697)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	288	Target Neighborhood Hits	860	Shared Neighborhood Hits	45
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

TAXB1_HUMAN
NC score	0.058561 (rank : 698)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	288	Target Neighborhood Hits	829	Shared Neighborhood Hits	73
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

ERC2_HUMAN
NC score	0.058391 (rank : 699)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	288	Target Neighborhood Hits	1156	Shared Neighborhood Hits	86
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

CYLN2_MOUSE
NC score	0.058373 (rank : 700)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	288	Target Neighborhood Hits	1002	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

SMC3_MOUSE
NC score	0.058329 (rank : 701)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	288	Target Neighborhood Hits	1187	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

CROCC_MOUSE
NC score	0.058319 (rank : 702)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	288	Target Neighborhood Hits	1460	Shared Neighborhood Hits	92
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

SAMN1_HUMAN
NC score	0.058279 (rank : 703)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	288	Target Neighborhood Hits	74	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

KMHN1_MOUSE
NC score	0.058243 (rank : 704)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	288	Target Neighborhood Hits	949	Shared Neighborhood Hits	80
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

CYLN2_HUMAN
NC score	0.058230 (rank : 705)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	288	Target Neighborhood Hits	1004	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

STK24_HUMAN
NC score	0.058090 (rank : 706)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	288	Target Neighborhood Hits	853	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

BPAEA_HUMAN
NC score	0.058087 (rank : 707)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	288	Target Neighborhood Hits	1369	Shared Neighborhood Hits	86
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SMC3_HUMAN
NC score	0.058081 (rank : 708)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	288	Target Neighborhood Hits	1186	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

RB6I2_HUMAN
NC score	0.058067 (rank : 709)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	288	Target Neighborhood Hits	1584	Shared Neighborhood Hits	98
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ERC2_MOUSE
NC score	0.058010 (rank : 710)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	288	Target Neighborhood Hits	1166	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ARHG1_MOUSE
NC score	0.057903 (rank : 711)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	288	Target Neighborhood Hits	266	Shared Neighborhood Hits	19
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ECT2_HUMAN
NC score	0.057876 (rank : 712)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	288	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RB6I2_MOUSE
NC score	0.057832 (rank : 713)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	288	Target Neighborhood Hits	1433	Shared Neighborhood Hits	91
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

AL2S2_MOUSE
NC score	0.057758 (rank : 714)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	288	Target Neighborhood Hits	709	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

EVPL_HUMAN
NC score	0.057729 (rank : 715)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	288	Target Neighborhood Hits	895	Shared Neighborhood Hits	77
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

OPTN_HUMAN
NC score	0.057723 (rank : 716)	θ value	5.27518 (rank : 245)
Query Neighborhood Hits	288	Target Neighborhood Hits	827	Shared Neighborhood Hits	72
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

TTBK2_HUMAN
NC score	0.057706 (rank : 717)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

MYO5C_HUMAN
NC score	0.057602 (rank : 718)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	288	Target Neighborhood Hits	1206	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYH14_MOUSE
NC score	0.057600 (rank : 719)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	288	Target Neighborhood Hits	1225	Shared Neighborhood Hits	86
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

SYCP1_HUMAN
NC score	0.057588 (rank : 720)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	288	Target Neighborhood Hits	1313	Shared Neighborhood Hits	83
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SPTB2_MOUSE
NC score	0.057540 (rank : 721)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	288	Target Neighborhood Hits	770	Shared Neighborhood Hits	69
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

AVR2B_MOUSE
NC score	0.057535 (rank : 722)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	288	Target Neighborhood Hits	749	Shared Neighborhood Hits	44
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

STK25_MOUSE
NC score	0.057504 (rank : 723)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

RRBP1_MOUSE
NC score	0.057434 (rank : 724)	θ value	8.99809 (rank : 284)
Query Neighborhood Hits	288	Target Neighborhood Hits	1650	Shared Neighborhood Hits	95
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

AVR2B_HUMAN
NC score	0.057402 (rank : 725)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CCD41_HUMAN
NC score	0.057372 (rank : 726)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	288	Target Neighborhood Hits	1139	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CROCC_HUMAN
NC score	0.057345 (rank : 727)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	288	Target Neighborhood Hits	1409	Shared Neighborhood Hits	92
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

STK25_HUMAN
NC score	0.057254 (rank : 728)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	288	Target Neighborhood Hits	853	Shared Neighborhood Hits	44
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MACF4_HUMAN
NC score	0.057227 (rank : 729)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	288	Target Neighborhood Hits	1321	Shared Neighborhood Hits	80
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

BRE1A_HUMAN
NC score	0.057181 (rank : 730)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	288	Target Neighborhood Hits	1071	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

SMC2_HUMAN
NC score	0.057149 (rank : 731)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	288	Target Neighborhood Hits	1405	Shared Neighborhood Hits	93
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

MYO3A_MOUSE
NC score	0.057123 (rank : 732)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	288	Target Neighborhood Hits	902	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

BMPR2_HUMAN
NC score	0.057094 (rank : 733)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	288	Target Neighborhood Hits	736	Shared Neighborhood Hits	44
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

RABE1_MOUSE
NC score	0.057072 (rank : 734)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	288	Target Neighborhood Hits	1105	Shared Neighborhood Hits	82
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

GRAP1_MOUSE
NC score	0.057069 (rank : 735)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	288	Target Neighborhood Hits	1234	Shared Neighborhood Hits	84
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

CR034_HUMAN
NC score	0.057058 (rank : 736)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	288	Target Neighborhood Hits	538	Shared Neighborhood Hits	68
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

IFT74_MOUSE
NC score	0.056970 (rank : 737)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	288	Target Neighborhood Hits	939	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

BPA1_MOUSE
NC score	0.056862 (rank : 738)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	288	Target Neighborhood Hits	1477	Shared Neighborhood Hits	85
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GOGA2_HUMAN
NC score	0.056815 (rank : 739)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

YSK4_HUMAN
NC score	0.056796 (rank : 740)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	288	Target Neighborhood Hits	921	Shared Neighborhood Hits	48
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

SYCP1_MOUSE
NC score	0.056771 (rank : 741)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	288	Target Neighborhood Hits	1456	Shared Neighborhood Hits	93
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

MYLK2_HUMAN
NC score	0.056759 (rank : 742)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	288	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

FLIP1_MOUSE
NC score	0.056739 (rank : 743)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	288	Target Neighborhood Hits	1176	Shared Neighborhood Hits	81
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGA5_MOUSE
NC score	0.056653 (rank : 744)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	288	Target Neighborhood Hits	1434	Shared Neighborhood Hits	94
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

AVR2A_MOUSE
NC score	0.056621 (rank : 745)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	288	Target Neighborhood Hits	767	Shared Neighborhood Hits	44
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BMPR2_MOUSE
NC score	0.056620 (rank : 746)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	288	Target Neighborhood Hits	738	Shared Neighborhood Hits	44
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

AVR2A_HUMAN
NC score	0.056619 (rank : 747)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	288	Target Neighborhood Hits	767	Shared Neighborhood Hits	44
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

CCD11_HUMAN
NC score	0.056602 (rank : 748)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	73
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

HIP1_HUMAN
NC score	0.056536 (rank : 749)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	288	Target Neighborhood Hits	1016	Shared Neighborhood Hits	77
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

PEPL_MOUSE
NC score	0.056495 (rank : 750)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	288	Target Neighborhood Hits	1105	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

CASP_HUMAN
NC score	0.056490 (rank : 751)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	288	Target Neighborhood Hits	1131	Shared Neighborhood Hits	89
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

BRE1B_MOUSE
NC score	0.056477 (rank : 752)	θ value	2.36792 (rank : 200)
Query Neighborhood Hits	288	Target Neighborhood Hits	970	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

AZI1_MOUSE
NC score	0.056421 (rank : 753)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	288	Target Neighborhood Hits	990	Shared Neighborhood Hits	83
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

GAS8_HUMAN
NC score	0.056373 (rank : 754)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	288	Target Neighborhood Hits	819	Shared Neighborhood Hits	67
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

TAXB1_MOUSE
NC score	0.056299 (rank : 755)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	76
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

CCD13_HUMAN
NC score	0.056205 (rank : 756)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	288	Target Neighborhood Hits	721	Shared Neighborhood Hits	66
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

PEPL_HUMAN
NC score	0.056187 (rank : 757)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	288	Target Neighborhood Hits	1141	Shared Neighborhood Hits	79
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

MD1L1_MOUSE
NC score	0.056176 (rank : 758)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	288	Target Neighborhood Hits	1001	Shared Neighborhood Hits	73
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

GOGA6_HUMAN
NC score	0.056005 (rank : 759)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

SMC4_HUMAN
NC score	0.055936 (rank : 760)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	288	Target Neighborhood Hits	937	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CK5P2_HUMAN
NC score	0.055922 (rank : 761)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	288	Target Neighborhood Hits	1433	Shared Neighborhood Hits	94
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

BRE1A_MOUSE
NC score	0.055907 (rank : 762)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	288	Target Neighborhood Hits	1025	Shared Neighborhood Hits	86
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CN145_HUMAN
NC score	0.055830 (rank : 763)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	288	Target Neighborhood Hits	1196	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CCD21_HUMAN
NC score	0.055747 (rank : 764)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	288	Target Neighborhood Hits	1228	Shared Neighborhood Hits	89
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

WNK3_HUMAN
NC score	0.055740 (rank : 765)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	288	Target Neighborhood Hits	948	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

CNTRB_MOUSE
NC score	0.055692 (rank : 766)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	288	Target Neighborhood Hits	1029	Shared Neighborhood Hits	76
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CARD9_HUMAN
NC score	0.055614 (rank : 767)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	288	Target Neighborhood Hits	602	Shared Neighborhood Hits	65
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CING_HUMAN
NC score	0.055580 (rank : 768)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	288	Target Neighborhood Hits	1275	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

NEK7_HUMAN
NC score	0.055559 (rank : 769)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	288	Target Neighborhood Hits	846	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

BI2L1_MOUSE
NC score	0.055557 (rank : 770)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	288	Target Neighborhood Hits	197	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SPTB2_HUMAN
NC score	0.055536 (rank : 771)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	65
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PRP4B_HUMAN
NC score	0.055533 (rank : 772)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	288	Target Neighborhood Hits	1030	Shared Neighborhood Hits	70
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

MD1L1_HUMAN
NC score	0.055514 (rank : 773)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

WNK2_HUMAN
NC score	0.055507 (rank : 774)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	288	Target Neighborhood Hits	1407	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

E2AK2_MOUSE
NC score	0.055492 (rank : 775)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	44
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

NEK7_MOUSE
NC score	0.055475 (rank : 776)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	288	Target Neighborhood Hits	847	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

STK16_MOUSE
NC score	0.055413 (rank : 777)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

RBCC1_HUMAN
NC score	0.055382 (rank : 778)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	288	Target Neighborhood Hits	1023	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

KTN1_HUMAN
NC score	0.055336 (rank : 779)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	288	Target Neighborhood Hits	1197	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

LBC_HUMAN
NC score	0.055259 (rank : 780)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	288	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

AL2S2_HUMAN
NC score	0.055229 (rank : 781)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	288	Target Neighborhood Hits	727	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

NEMO_HUMAN
NC score	0.055166 (rank : 782)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	288	Target Neighborhood Hits	820	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEK6_HUMAN
NC score	0.055160 (rank : 783)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.055157 (rank : 784)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	288	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

CJ118_MOUSE
NC score	0.055131 (rank : 785)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	288	Target Neighborhood Hits	1132	Shared Neighborhood Hits	77
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

HOOK3_MOUSE
NC score	0.055119 (rank : 786)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	288	Target Neighborhood Hits	1007	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

NEK1_MOUSE
NC score	0.055063 (rank : 787)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	288	Target Neighborhood Hits	1311	Shared Neighborhood Hits	81
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PRP4B_MOUSE
NC score	0.054994 (rank : 788)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	288	Target Neighborhood Hits	1040	Shared Neighborhood Hits	66
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

NEK1_HUMAN
NC score	0.054964 (rank : 789)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	288	Target Neighborhood Hits	1129	Shared Neighborhood Hits	79
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

CT2NL_HUMAN
NC score	0.054924 (rank : 790)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	79
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

HOOK3_HUMAN
NC score	0.054917 (rank : 791)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	288	Target Neighborhood Hits	1070	Shared Neighborhood Hits	85
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

K0555_HUMAN
NC score	0.054907 (rank : 792)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	288	Target Neighborhood Hits	880	Shared Neighborhood Hits	70
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

MYH14_HUMAN
NC score	0.054843 (rank : 793)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	288	Target Neighborhood Hits	995	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

INCE_HUMAN
NC score	0.054786 (rank : 794)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	288	Target Neighborhood Hits	978	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

RPGR1_MOUSE
NC score	0.054735 (rank : 795)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	288	Target Neighborhood Hits	713	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

ULK1_MOUSE
NC score	0.054731 (rank : 796)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	288	Target Neighborhood Hits	1214	Shared Neighborhood Hits	55
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

MP2K5_MOUSE
NC score	0.054581 (rank : 797)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	288	Target Neighborhood Hits	840	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK4_MOUSE
NC score	0.054545 (rank : 798)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	288	Target Neighborhood Hits	899	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

GOGA5_HUMAN
NC score	0.054541 (rank : 799)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	288	Target Neighborhood Hits	1168	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

WNK1_HUMAN
NC score	0.054522 (rank : 800)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	288	Target Neighborhood Hits	1158	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
NC score	0.054485 (rank : 801)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	288	Target Neighborhood Hits	1179	Shared Neighborhood Hits	53
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CCD91_MOUSE
NC score	0.054472 (rank : 802)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	288	Target Neighborhood Hits	699	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

ARHG2_HUMAN
NC score	0.054413 (rank : 803)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	288	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

MP2K7_HUMAN
NC score	0.054401 (rank : 804)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

ARHG2_MOUSE
NC score	0.054351 (rank : 805)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	288	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CCD39_HUMAN
NC score	0.054348 (rank : 806)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	288	Target Neighborhood Hits	868	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

RRBP1_HUMAN
NC score	0.054333 (rank : 807)	θ value	6.88961 (rank : 266)
Query Neighborhood Hits	288	Target Neighborhood Hits	1306	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

NEK3_HUMAN
NC score	0.054255 (rank : 808)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	288	Target Neighborhood Hits	865	Shared Neighborhood Hits	47
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

CT2NL_MOUSE
NC score	0.054227 (rank : 809)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	288	Target Neighborhood Hits	902	Shared Neighborhood Hits	76
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MAK_MOUSE
NC score	0.054220 (rank : 810)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	46
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

RBCC1_MOUSE
NC score	0.054198 (rank : 811)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	288	Target Neighborhood Hits	1048	Shared Neighborhood Hits	77
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

CD2L7_HUMAN
NC score	0.054120 (rank : 812)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	288	Target Neighborhood Hits	1275	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CCD27_HUMAN
NC score	0.053966 (rank : 813)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	288	Target Neighborhood Hits	594	Shared Neighborhood Hits	66
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

ICK_HUMAN
NC score	0.053947 (rank : 814)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MP2K2_MOUSE
NC score	0.053913 (rank : 815)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

T3JAM_MOUSE
NC score	0.053870 (rank : 816)	θ value	1.81305 (rank : 196)
Query Neighborhood Hits	288	Target Neighborhood Hits	535	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

STK16_HUMAN
NC score	0.053867 (rank : 817)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

LRC45_MOUSE
NC score	0.053842 (rank : 818)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

IF3A_MOUSE
NC score	0.053835 (rank : 819)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	288	Target Neighborhood Hits	871	Shared Neighborhood Hits	73
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

ICK_MOUSE
NC score	0.053805 (rank : 820)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	288	Target Neighborhood Hits	860	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

CALD1_HUMAN
NC score	0.053763 (rank : 821)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	288	Target Neighborhood Hits	959	Shared Neighborhood Hits	77
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

IKKB_HUMAN
NC score	0.053761 (rank : 822)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	288	Target Neighborhood Hits	980	Shared Neighborhood Hits	72
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CCD21_MOUSE
NC score	0.053758 (rank : 823)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	288	Target Neighborhood Hits	1135	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

NAF1_MOUSE
NC score	0.053755 (rank : 824)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	288	Target Neighborhood Hits	852	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

TMF1_HUMAN
NC score	0.053718 (rank : 825)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	76
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

EVPL_MOUSE
NC score	0.053686 (rank : 826)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	288	Target Neighborhood Hits	952	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

MP2K2_HUMAN
NC score	0.053655 (rank : 827)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

TUFT1_HUMAN
NC score	0.053647 (rank : 828)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	288	Target Neighborhood Hits	686	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

CD2L1_MOUSE
NC score	0.053633 (rank : 829)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	288	Target Neighborhood Hits	1463	Shared Neighborhood Hits	108
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

LIPA2_MOUSE
NC score	0.053632 (rank : 830)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	288	Target Neighborhood Hits	1282	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

NEK4_HUMAN
NC score	0.053561 (rank : 831)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	288	Target Neighborhood Hits	883	Shared Neighborhood Hits	45
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

SYNE2_HUMAN
NC score	0.053543 (rank : 832)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	288	Target Neighborhood Hits	1323	Shared Neighborhood Hits	84
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

NAF1_HUMAN
NC score	0.053519 (rank : 833)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	288	Target Neighborhood Hits	937	Shared Neighborhood Hits	71
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

SOCS3_HUMAN
NC score	0.053485 (rank : 834)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	288	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

NEMO_MOUSE
NC score	0.053395 (rank : 835)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	288	Target Neighborhood Hits	658	Shared Neighborhood Hits	65
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

SBK1_MOUSE
NC score	0.053394 (rank : 836)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	288	Target Neighborhood Hits	824	Shared Neighborhood Hits	44
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

FGD3_MOUSE
NC score	0.053331 (rank : 837)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	23
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

LIPA1_HUMAN
NC score	0.053256 (rank : 838)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	288	Target Neighborhood Hits	1294	Shared Neighborhood Hits	91
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

PLCB4_HUMAN
NC score	0.053221 (rank : 839)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	288	Target Neighborhood Hits	658	Shared Neighborhood Hits	64
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

IKKA_HUMAN
NC score	0.053182 (rank : 840)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	288	Target Neighborhood Hits	863	Shared Neighborhood Hits	49
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

AL2S7_HUMAN
NC score	0.053154 (rank : 841)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	288	Target Neighborhood Hits	831	Shared Neighborhood Hits	44
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

UTRO_HUMAN
NC score	0.053146 (rank : 842)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	288	Target Neighborhood Hits	960	Shared Neighborhood Hits	68
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

MAK_HUMAN
NC score	0.053142 (rank : 843)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	288	Target Neighborhood Hits	857	Shared Neighborhood Hits	46
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

ULK2_MOUSE
NC score	0.053105 (rank : 844)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	288	Target Neighborhood Hits	943	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

SN1L2_HUMAN
NC score	0.053083 (rank : 845)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	288	Target Neighborhood Hits	964	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

IKKB_MOUSE
NC score	0.053067 (rank : 846)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	288	Target Neighborhood Hits	984	Shared Neighborhood Hits	77
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

TUFT1_MOUSE
NC score	0.053046 (rank : 847)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	288	Target Neighborhood Hits	732	Shared Neighborhood Hits	67
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

ULK1_HUMAN
NC score	0.053032 (rank : 848)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	288	Target Neighborhood Hits	1121	Shared Neighborhood Hits	51
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

NEK3_MOUSE
NC score	0.052942 (rank : 849)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	288	Target Neighborhood Hits	854	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

TGFR2_MOUSE
NC score	0.052890 (rank : 850)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

SN1L2_MOUSE
NC score	0.052841 (rank : 851)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	288	Target Neighborhood Hits	944	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

RUFY2_HUMAN
NC score	0.052816 (rank : 852)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	288	Target Neighborhood Hits	1208	Shared Neighborhood Hits	83
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

CD2L5_HUMAN
NC score	0.052812 (rank : 853)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	288	Target Neighborhood Hits	987	Shared Neighborhood Hits	50
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

TGFR2_HUMAN
NC score	0.052810 (rank : 854)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	288	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ULK2_HUMAN
NC score	0.052767 (rank : 855)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	288	Target Neighborhood Hits	979	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CD2L5_MOUSE
NC score	0.052749 (rank : 856)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	288	Target Neighborhood Hits	1011	Shared Neighborhood Hits	49
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

SBK1_HUMAN
NC score	0.052719 (rank : 857)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	288	Target Neighborhood Hits	828	Shared Neighborhood Hits	44
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

CD2L1_HUMAN
NC score	0.052664 (rank : 858)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	288	Target Neighborhood Hits	1467	Shared Neighborhood Hits	107
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

KPCB_MOUSE
NC score	0.052658 (rank : 859)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	288	Target Neighborhood Hits	1117	Shared Neighborhood Hits	56
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RFIP3_HUMAN
NC score	0.052587 (rank : 860)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	288	Target Neighborhood Hits	1055	Shared Neighborhood Hits	76
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SAMN1_MOUSE
NC score	0.052512 (rank : 861)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	288	Target Neighborhood Hits	69	Shared Neighborhood Hits	35
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

MP2K5_HUMAN
NC score	0.052448 (rank : 862)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	44
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

IKKE_MOUSE
NC score	0.052446 (rank : 863)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	288	Target Neighborhood Hits	848	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

E2AK1_HUMAN
NC score	0.052438 (rank : 864)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

BRSK2_HUMAN
NC score	0.052352 (rank : 865)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	288	Target Neighborhood Hits	897	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MP2K3_MOUSE
NC score	0.052344 (rank : 866)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

KPCB_HUMAN
NC score	0.052268 (rank : 867)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	288	Target Neighborhood Hits	1121	Shared Neighborhood Hits	56
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

M3K3_HUMAN
NC score	0.052257 (rank : 868)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	288	Target Neighborhood Hits	885	Shared Neighborhood Hits	48
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MACF1_HUMAN
NC score	0.052224 (rank : 869)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	288	Target Neighborhood Hits	1341	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

STK4_HUMAN
NC score	0.052218 (rank : 870)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	288	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK3_HUMAN
NC score	0.052193 (rank : 871)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	288	Target Neighborhood Hits	861	Shared Neighborhood Hits	47
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

TCRG1_HUMAN
NC score	0.052158 (rank : 872)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	288	Target Neighborhood Hits	929	Shared Neighborhood Hits	63
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

STK4_MOUSE
NC score	0.052146 (rank : 873)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	288	Target Neighborhood Hits	873	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

IKKA_MOUSE
NC score	0.052138 (rank : 874)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	49
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

PCNT_MOUSE
NC score	0.052134 (rank : 875)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	288	Target Neighborhood Hits	1207	Shared Neighborhood Hits	84
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

STK3_MOUSE
NC score	0.052107 (rank : 876)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	288	Target Neighborhood Hits	869	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

INCE_MOUSE
NC score	0.052077 (rank : 877)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	288	Target Neighborhood Hits	903	Shared Neighborhood Hits	75
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

MP2K6_HUMAN
NC score	0.052071 (rank : 878)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MACF1_MOUSE
NC score	0.052042 (rank : 879)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	288	Target Neighborhood Hits	1313	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

LRRF2_HUMAN
NC score	0.052037 (rank : 880)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	288	Target Neighborhood Hits	791	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

M3K3_MOUSE
NC score	0.052029 (rank : 881)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	288	Target Neighborhood Hits	876	Shared Neighborhood Hits	46
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

FGD4_HUMAN
NC score	0.052013 (rank : 882)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	288	Target Neighborhood Hits	219	Shared Neighborhood Hits	31
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

TCRG1_MOUSE
NC score	0.052000 (rank : 883)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	288	Target Neighborhood Hits	947	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

FGD2_HUMAN
NC score	0.051992 (rank : 884)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	288	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

SWP70_HUMAN
NC score	0.051926 (rank : 885)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	288	Target Neighborhood Hits	973	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MP2K1_MOUSE
NC score	0.051923 (rank : 886)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

JIP3_MOUSE
NC score	0.051913 (rank : 887)	θ value	3.0926 (rank : 218)
Query Neighborhood Hits	288	Target Neighborhood Hits	759	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

TLK2_MOUSE
NC score	0.051911 (rank : 888)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	288	Target Neighborhood Hits	1088	Shared Neighborhood Hits	82
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

MP2K6_MOUSE
NC score	0.051859 (rank : 889)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	44
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NUAK1_MOUSE
NC score	0.051825 (rank : 890)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	288	Target Neighborhood Hits	881	Shared Neighborhood Hits	45
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

IF3A_HUMAN
NC score	0.051798 (rank : 891)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	288	Target Neighborhood Hits	875	Shared Neighborhood Hits	70
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

MP2K1_HUMAN
NC score	0.051763 (rank : 892)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	288	Target Neighborhood Hits	826	Shared Neighborhood Hits	44
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NUAK1_HUMAN
NC score	0.051722 (rank : 893)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	44
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NEK2_HUMAN
NC score	0.051707 (rank : 894)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	288	Target Neighborhood Hits	908	Shared Neighborhood Hits	58
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

TSSK4_HUMAN
NC score	0.051695 (rank : 895)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	288	Target Neighborhood Hits	836	Shared Neighborhood Hits	44
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

SMC2_MOUSE
NC score	0.051681 (rank : 896)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	288	Target Neighborhood Hits	1131	Shared Neighborhood Hits	80
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

FYCO1_MOUSE
NC score	0.051675 (rank : 897)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	288	Target Neighborhood Hits	1059	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TLK2_HUMAN
NC score	0.051670 (rank : 898)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	288	Target Neighborhood Hits	1044	Shared Neighborhood Hits	77
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

SN1L1_MOUSE
NC score	0.051654 (rank : 899)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	288	Target Neighborhood Hits	895	Shared Neighborhood Hits	47
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

CK5P2_MOUSE
NC score	0.051628 (rank : 900)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	288	Target Neighborhood Hits	1151	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

SWP70_MOUSE
NC score	0.051613 (rank : 901)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	288	Target Neighborhood Hits	1097	Shared Neighborhood Hits	81
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

T3JAM_HUMAN
NC score	0.051583 (rank : 902)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	288	Target Neighborhood Hits	533	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

MP2K3_HUMAN
NC score	0.051568 (rank : 903)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	288	Target Neighborhood Hits	825	Shared Neighborhood Hits	44
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MYO3B_HUMAN
NC score	0.051567 (rank : 904)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	288	Target Neighborhood Hits	923	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

FGD3_HUMAN
NC score	0.051502 (rank : 905)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	288	Target Neighborhood Hits	249	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

BICD1_HUMAN
NC score	0.051472 (rank : 906)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	288	Target Neighborhood Hits	844	Shared Neighborhood Hits	69
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

ANR26_HUMAN
NC score	0.051471 (rank : 907)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	288	Target Neighborhood Hits	1614	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

MYO5A_HUMAN
NC score	0.051401 (rank : 908)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	288	Target Neighborhood Hits	1092	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

CCDC6_HUMAN
NC score	0.051356 (rank : 909)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	288	Target Neighborhood Hits	723	Shared Neighborhood Hits	68
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

BICD2_HUMAN
NC score	0.051352 (rank : 910)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

E2AK2_HUMAN
NC score	0.051335 (rank : 911)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	288	Target Neighborhood Hits	856	Shared Neighborhood Hits	46
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

OFD1_HUMAN
NC score	0.051331 (rank : 912)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	66
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

CD2L2_HUMAN
NC score	0.051331 (rank : 913)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	288	Target Neighborhood Hits	1439	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

BICD2_MOUSE
NC score	0.051287 (rank : 914)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	288	Target Neighborhood Hits	864	Shared Neighborhood Hits	73
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BMP2K_HUMAN
NC score	0.051243 (rank : 915)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	288	Target Neighborhood Hits	867	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

PLEC1_HUMAN
NC score	0.051237 (rank : 916)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	288	Target Neighborhood Hits	1326	Shared Neighborhood Hits	84
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PININ_HUMAN
NC score	0.051189 (rank : 917)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	288	Target Neighborhood Hits	753	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

LRC45_HUMAN
NC score	0.051133 (rank : 918)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	288	Target Neighborhood Hits	933	Shared Neighborhood Hits	71
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

SMC4_MOUSE
NC score	0.051128 (rank : 919)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	288	Target Neighborhood Hits	830	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

RBP1_HUMAN
NC score	0.051111 (rank : 920)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	288	Target Neighborhood Hits	521	Shared Neighborhood Hits	55
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

M3K15_HUMAN
NC score	0.051029 (rank : 921)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	288	Target Neighborhood Hits	914	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

CUTL1_MOUSE
NC score	0.051013 (rank : 922)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	94
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

TSSK4_MOUSE
NC score	0.050948 (rank : 923)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	288	Target Neighborhood Hits	840	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KPCA_MOUSE
NC score	0.050936 (rank : 924)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	288	Target Neighborhood Hits	1067	Shared Neighborhood Hits	57
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

IKKE_HUMAN
NC score	0.050740 (rank : 925)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	48
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MP2K4_HUMAN
NC score	0.050735 (rank : 926)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	288	Target Neighborhood Hits	832	Shared Neighborhood Hits	44
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

BRSK1_HUMAN
NC score	0.050724 (rank : 927)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	288	Target Neighborhood Hits	942	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

SOCS3_MOUSE
NC score	0.050723 (rank : 928)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	288	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

TBK1_MOUSE
NC score	0.050722 (rank : 929)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MP2K4_MOUSE
NC score	0.050721 (rank : 930)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	288	Target Neighborhood Hits	833	Shared Neighborhood Hits	44
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

M3K2_HUMAN
NC score	0.050711 (rank : 931)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	288	Target Neighborhood Hits	849	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

RHG25_HUMAN
NC score	0.050648 (rank : 932)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	288	Target Neighborhood Hits	550	Shared Neighborhood Hits	57
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

NUAK2_HUMAN
NC score	0.050618 (rank : 933)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	288	Target Neighborhood Hits	874	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

GAS8_MOUSE
NC score	0.050618 (rank : 934)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	288	Target Neighborhood Hits	622	Shared Neighborhood Hits	58
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

CN145_MOUSE
NC score	0.050618 (rank : 935)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	288	Target Neighborhood Hits	916	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

NIM1_HUMAN
NC score	0.050618 (rank : 936)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KPCA_HUMAN
NC score	0.050594 (rank : 937)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	288	Target Neighborhood Hits	1070	Shared Neighborhood Hits	56
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

CDK9_MOUSE
NC score	0.050587 (rank : 938)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

JIP3_HUMAN
NC score	0.050563 (rank : 939)	θ value	1.81305 (rank : 191)
Query Neighborhood Hits	288	Target Neighborhood Hits	1039	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

PFTK1_MOUSE
NC score	0.050556 (rank : 940)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	288	Target Neighborhood Hits	835	Shared Neighborhood Hits	46
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

NIM1_MOUSE
NC score	0.050543 (rank : 941)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	288	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SN1L1_HUMAN
NC score	0.050535 (rank : 942)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	288	Target Neighborhood Hits	911	Shared Neighborhood Hits	44
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SDCG8_MOUSE
NC score	0.050524 (rank : 943)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	71
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

M4K1_MOUSE
NC score	0.050480 (rank : 944)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	288	Target Neighborhood Hits	858	Shared Neighborhood Hits	44
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MARK4_MOUSE
NC score	0.050455 (rank : 945)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	288	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

CDK9_HUMAN
NC score	0.050455 (rank : 946)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	288	Target Neighborhood Hits	822	Shared Neighborhood Hits	44
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

RBP1_MOUSE
NC score	0.050447 (rank : 947)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	288	Target Neighborhood Hits	493	Shared Neighborhood Hits	50
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

MARK4_HUMAN
NC score	0.050444 (rank : 948)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	288	Target Neighborhood Hits	886	Shared Neighborhood Hits	45
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

XE7_HUMAN
NC score	0.050376 (rank : 949)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	288	Target Neighborhood Hits	738	Shared Neighborhood Hits	71
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

TBK1_HUMAN
NC score	0.050366 (rank : 950)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	288	Target Neighborhood Hits	861	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CCD11_MOUSE
NC score	0.050286 (rank : 951)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	288	Target Neighborhood Hits	498	Shared Neighborhood Hits	58
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

FGD4_MOUSE
NC score	0.050282 (rank : 952)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

CCD62_HUMAN
NC score	0.050255 (rank : 953)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	288	Target Neighborhood Hits	631	Shared Neighborhood Hits	60
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

MK04_HUMAN
NC score	0.050248 (rank : 954)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	288	Target Neighborhood Hits	837	Shared Neighborhood Hits	46
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK11_HUMAN
NC score	0.050239 (rank : 955)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	288	Target Neighborhood Hits	823	Shared Neighborhood Hits	44
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

NEK2_MOUSE
NC score	0.050233 (rank : 956)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	288	Target Neighborhood Hits	876	Shared Neighborhood Hits	49
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

UACA_MOUSE
NC score	0.050226 (rank : 957)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	288	Target Neighborhood Hits	1620	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

NEK9_HUMAN
NC score	0.050219 (rank : 958)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	288	Target Neighborhood Hits	900	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

AAPK1_HUMAN
NC score	0.050205 (rank : 959)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	288	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

CCD27_MOUSE
NC score	0.050190 (rank : 960)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	288	Target Neighborhood Hits	461	Shared Neighborhood Hits	64
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

SEC20_MOUSE
NC score	0.050178 (rank : 961)	θ value	6.88961 (rank : 267)
Query Neighborhood Hits	288	Target Neighborhood Hits	323	Shared Neighborhood Hits	46
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

PFTK1_HUMAN
NC score	0.050139 (rank : 962)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	288	Target Neighborhood Hits	834	Shared Neighborhood Hits	45
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

INVO_MOUSE
NC score	0.050108 (rank : 963)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	288	Target Neighborhood Hits	474	Shared Neighborhood Hits	50
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

HOOK1_MOUSE
NC score	0.050104 (rank : 964)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	288	Target Neighborhood Hits	910	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MARK3_HUMAN
NC score	0.050087 (rank : 965)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	288	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

CYTSA_MOUSE
NC score	0.050085 (rank : 966)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	288	Target Neighborhood Hits	1104	Shared Neighborhood Hits	80
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

MOR2A_MOUSE
NC score	0.046005 (rank : 967)	θ value	0.0252991 (rank : 81)
Query Neighborhood Hits	288	Target Neighborhood Hits	220	Shared Neighborhood Hits	17
SwissProt Accessions	Q69ZX6, Q5QNQ7, Q6P547	Gene names	Morc2a, Kiaa0852, Zcwcc1
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2A (Zinc finger CW-type coiled-coil domain protein 1).

CN045_HUMAN
NC score	0.044861 (rank : 968)	θ value	5.27518 (rank : 238)
Query Neighborhood Hits	288	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

SKIL_MOUSE
NC score	0.044404 (rank : 969)	θ value	6.88961 (rank : 268)
Query Neighborhood Hits	288	Target Neighborhood Hits	719	Shared Neighborhood Hits	68
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

RILP_MOUSE
NC score	0.044353 (rank : 970)	θ value	5.27518 (rank : 246)
Query Neighborhood Hits	288	Target Neighborhood Hits	257	Shared Neighborhood Hits	37
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

KIF4A_HUMAN
NC score	0.043963 (rank : 971)	θ value	5.27518 (rank : 242)
Query Neighborhood Hits	288	Target Neighborhood Hits	1159	Shared Neighborhood Hits	80
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CC47_MOUSE
NC score	0.042684 (rank : 972)	θ value	0.813845 (rank : 163)
Query Neighborhood Hits	288	Target Neighborhood Hits	245	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

CACB3_HUMAN
NC score	0.041038 (rank : 973)	θ value	1.81305 (rank : 188)
Query Neighborhood Hits	288	Target Neighborhood Hits	45	Shared Neighborhood Hits	14
SwissProt Accessions	P54284, Q13913	Gene names	CACNB3, CACNLB3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3).

OXR1_MOUSE
NC score	0.040713 (rank : 974)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	288	Target Neighborhood Hits	516	Shared Neighborhood Hits	36
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

CACB3_MOUSE
NC score	0.040546 (rank : 975)	θ value	4.03905 (rank : 227)
Query Neighborhood Hits	288	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

SPTN2_HUMAN
NC score	0.040370 (rank : 976)	θ value	8.99809 (rank : 286)
Query Neighborhood Hits	288	Target Neighborhood Hits	535	Shared Neighborhood Hits	51
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

FA50A_MOUSE
NC score	0.038153 (rank : 977)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	288	Target Neighborhood Hits	293	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

HNRCL_HUMAN
NC score	0.037438 (rank : 978)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	288	Target Neighborhood Hits	232	Shared Neighborhood Hits	27
SwissProt Accessions	O60812	Gene names	HNRPCL1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP core protein C-like 1).

UBP34_HUMAN
NC score	0.036929 (rank : 979)	θ value	0.279714 (rank : 140)
Query Neighborhood Hits	288	Target Neighborhood Hits	210	Shared Neighborhood Hits	15
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

UBP34_MOUSE
NC score	0.035663 (rank : 980)	θ value	0.365318 (rank : 148)
Query Neighborhood Hits	288	Target Neighborhood Hits	189	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

HNRPC_HUMAN
NC score	0.034730 (rank : 981)	θ value	1.81305 (rank : 190)
Query Neighborhood Hits	288	Target Neighborhood Hits	210	Shared Neighborhood Hits	23
SwissProt Accessions	P07910, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3	Gene names	HNRPC
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

CTTB2_HUMAN
NC score	0.034727 (rank : 982)	θ value	2.36792 (rank : 202)
Query Neighborhood Hits	288	Target Neighborhood Hits	1061	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

OS9_HUMAN
NC score	0.034528 (rank : 983)	θ value	2.36792 (rank : 208)
Query Neighborhood Hits	288	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

HNRPC_MOUSE
NC score	0.033993 (rank : 984)	θ value	3.0926 (rank : 215)
Query Neighborhood Hits	288	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z204, Q3TLB5, Q501Q3, Q8C2G5, Q99KE2, Q9CQT3, Q9CY83	Gene names	Hnrpc, Hnrnpc
Domain Architecture
Description	Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2).

PHF14_HUMAN
NC score	0.033814 (rank : 985)	θ value	1.81305 (rank : 193)
Query Neighborhood Hits	288	Target Neighborhood Hits	447	Shared Neighborhood Hits	41
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

SMRC2_HUMAN
NC score	0.031738 (rank : 986)	θ value	1.38821 (rank : 187)
Query Neighborhood Hits	288	Target Neighborhood Hits	499	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

NCOA7_MOUSE
NC score	0.031618 (rank : 987)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	288	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q6DFV7, Q3TAR1, Q3UNB3, Q66K05, Q6ZQM4, Q8BJ15, Q8BJ39	Gene names	Ncoa7
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7.

BSCL2_MOUSE
NC score	0.031305 (rank : 988)	θ value	1.38821 (rank : 176)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

AKA12_HUMAN
NC score	0.030450 (rank : 989)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	288	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

SMRC1_MOUSE
NC score	0.030229 (rank : 990)	θ value	6.88961 (rank : 269)
Query Neighborhood Hits	288	Target Neighborhood Hits	459	Shared Neighborhood Hits	31
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

PHF14_MOUSE
NC score	0.030017 (rank : 991)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	288	Target Neighborhood Hits	342	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

RRP5_HUMAN
NC score	0.029559 (rank : 992)	θ value	5.27518 (rank : 247)
Query Neighborhood Hits	288	Target Neighborhood Hits	291	Shared Neighborhood Hits	27
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

SMRC2_MOUSE
NC score	0.029002 (rank : 993)	θ value	3.0926 (rank : 224)
Query Neighborhood Hits	288	Target Neighborhood Hits	487	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

MORC2_HUMAN
NC score	0.028445 (rank : 994)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	288	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

OXRP_HUMAN
NC score	0.028241 (rank : 995)	θ value	0.0961366 (rank : 115)
Query Neighborhood Hits	288	Target Neighborhood Hits	544	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

CACB2_HUMAN
NC score	0.026928 (rank : 996)	θ value	6.88961 (rank : 255)
Query Neighborhood Hits	288	Target Neighborhood Hits	99	Shared Neighborhood Hits	18
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

EI2BE_MOUSE
NC score	0.024855 (rank : 997)	θ value	1.81305 (rank : 189)
Query Neighborhood Hits	288	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHW4, Q3TU39	Gene names	Eif2b5
Domain Architecture	No domain graphic available
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

APLP1_MOUSE
NC score	0.024823 (rank : 998)	θ value	5.27518 (rank : 236)
Query Neighborhood Hits	288	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

PRP40_HUMAN
NC score	0.024618 (rank : 999)	θ value	6.88961 (rank : 264)
Query Neighborhood Hits	288	Target Neighborhood Hits	442	Shared Neighborhood Hits	42
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

NUP98_HUMAN
NC score	0.022382 (rank : 1000)	θ value	4.03905 (rank : 233)
Query Neighborhood Hits	288	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

VIME_HUMAN
NC score	0.022130 (rank : 1001)	θ value	8.99809 (rank : 288)
Query Neighborhood Hits	288	Target Neighborhood Hits	706	Shared Neighborhood Hits	63
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

LAMA2_HUMAN
NC score	0.021282 (rank : 1002)	θ value	3.0926 (rank : 219)
Query Neighborhood Hits	288	Target Neighborhood Hits	1092	Shared Neighborhood Hits	57
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

TCAL5_HUMAN
NC score	0.019172 (rank : 1003)	θ value	6.88961 (rank : 270)
Query Neighborhood Hits	288	Target Neighborhood Hits	806	Shared Neighborhood Hits	37
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

MYRIP_HUMAN
NC score	0.018676 (rank : 1004)	θ value	5.27518 (rank : 244)
Query Neighborhood Hits	288	Target Neighborhood Hits	269	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

BFSP2_HUMAN
NC score	0.018406 (rank : 1005)	θ value	5.27518 (rank : 237)
Query Neighborhood Hits	288	Target Neighborhood Hits	348	Shared Neighborhood Hits	41
SwissProt Accessions	Q13515, Q9HBW5	Gene names	BFSP2
Domain Architecture
Description	Phakinin (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 49) (CP49) (49 kDa cytoskeletal protein) (CP 47) (CP47) (Lens intermediate filament-like light) (LIFL-L).

LEO1_HUMAN
NC score	0.015926 (rank : 1006)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	288	Target Neighborhood Hits	958	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

RPGR_HUMAN
NC score	0.012900 (rank : 1007)	θ value	6.88961 (rank : 265)
Query Neighborhood Hits	288	Target Neighborhood Hits	279	Shared Neighborhood Hits	18
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

UBP37_HUMAN
NC score	0.012418 (rank : 1008)	θ value	5.27518 (rank : 253)
Query Neighborhood Hits	288	Target Neighborhood Hits	208	Shared Neighborhood Hits	13
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

MAD4_HUMAN
NC score	0.012021 (rank : 1009)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	288	Target Neighborhood Hits	94	Shared Neighborhood Hits	9
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

CA082_HUMAN
NC score	0.011946 (rank : 1010)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	288	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXW5, Q49AS7, Q9H8Y2	Gene names	C1orf82
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82.

ADA30_HUMAN
NC score	0.009996 (rank : 1011)	θ value	0.813845 (rank : 162)
Query Neighborhood Hits	288	Target Neighborhood Hits	391	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

DEN2A_HUMAN
NC score	0.008852 (rank : 1012)	θ value	6.88961 (rank : 256)
Query Neighborhood Hits	288	Target Neighborhood Hits	83	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

TCEA3_MOUSE
NC score	0.007147 (rank : 1013)	θ value	8.99809 (rank : 287)
Query Neighborhood Hits	288	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	P23881, O88710, Q9CTZ8, Q9DCZ5	Gene names	Tcea3, Tfiish
Domain Architecture
Description	Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h).

TRI22_HUMAN
NC score	0.003641 (rank : 1014)	θ value	5.27518 (rank : 252)
Query Neighborhood Hits	288	Target Neighborhood Hits	396	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

HXC10_HUMAN
NC score	0.003340 (rank : 1015)	θ value	3.0926 (rank : 216)
Query Neighborhood Hits	288	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

HXC10_MOUSE
NC score	0.001520 (rank : 1016)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	288	Target Neighborhood Hits	417	Shared Neighborhood Hits	6
SwissProt Accessions	P31257, P31312, Q7TMT7	Gene names	Hoxc10, Hox-3.6, Hoxc-10
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C10 (Hox-3.6).

PEG3_MOUSE
NC score	-0.003526 (rank : 1017)	θ value	3.0926 (rank : 222)
Query Neighborhood Hits	288	Target Neighborhood Hits	1101	Shared Neighborhood Hits	14
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

ZFY2_MOUSE
NC score	-0.007342 (rank : 1018)	θ value	5.27518 (rank : 254)
Query Neighborhood Hits	288	Target Neighborhood Hits	795	Shared Neighborhood Hits	4
SwissProt Accessions	P20662	Gene names	Zfy2, Zfy-2
Domain Architecture
Description	Zinc finger Y-chromosomal protein 2.