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Network neighborhood for query Sequence : PGFRL_MOUSE

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PGFRL_MOUSE
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PGFRL_HUMAN
θ value	0 (rank : 1)	NC score	0.986898 (rank : 2)
Query Neighborhood Hits	106	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PGFRL_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	106	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

VGFR1_MOUSE
θ value	5.99374e-20 (rank : 3)	NC score	0.333338 (rank : 4)
Query Neighborhood Hits	106	Target Neighborhood Hits	1118	Shared Neighborhood Hits	98
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR1_HUMAN
θ value	5.07402e-19 (rank : 4)	NC score	0.336544 (rank : 3)
Query Neighborhood Hits	106	Target Neighborhood Hits	1109	Shared Neighborhood Hits	97
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR2_MOUSE
θ value	1.52774e-15 (rank : 5)	NC score	0.328401 (rank : 6)
Query Neighborhood Hits	106	Target Neighborhood Hits	1089	Shared Neighborhood Hits	96
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

PGFRA_MOUSE
θ value	3.76295e-14 (rank : 6)	NC score	0.312416 (rank : 12)
Query Neighborhood Hits	106	Target Neighborhood Hits	975	Shared Neighborhood Hits	84
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VGFR2_HUMAN
θ value	6.41864e-14 (rank : 7)	NC score	0.331126 (rank : 5)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	98
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

PGFRB_HUMAN
θ value	1.42992e-13 (rank : 8)	NC score	0.309712 (rank : 13)
Query Neighborhood Hits	106	Target Neighborhood Hits	962	Shared Neighborhood Hits	81
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	1.42992e-13 (rank : 9)	NC score	0.312551 (rank : 11)
Query Neighborhood Hits	106	Target Neighborhood Hits	960	Shared Neighborhood Hits	81
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VGFR3_HUMAN
θ value	7.09661e-13 (rank : 10)	NC score	0.321263 (rank : 8)
Query Neighborhood Hits	106	Target Neighborhood Hits	1037	Shared Neighborhood Hits	94
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	1.58096e-12 (rank : 11)	NC score	0.322212 (rank : 7)
Query Neighborhood Hits	106	Target Neighborhood Hits	1056	Shared Neighborhood Hits	94
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

PGFRA_HUMAN
θ value	2.0648e-12 (rank : 12)	NC score	0.308827 (rank : 14)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	86
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

KIT_MOUSE
θ value	8.67504e-11 (rank : 13)	NC score	0.299223 (rank : 18)
Query Neighborhood Hits	106	Target Neighborhood Hits	949	Shared Neighborhood Hits	85
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_HUMAN
θ value	9.59137e-10 (rank : 14)	NC score	0.293512 (rank : 21)
Query Neighborhood Hits	106	Target Neighborhood Hits	953	Shared Neighborhood Hits	86
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CSF1R_MOUSE
θ value	1.87187e-05 (rank : 15)	NC score	0.288436 (rank : 23)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	89
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_HUMAN
θ value	7.1131e-05 (rank : 16)	NC score	0.283031 (rank : 25)
Query Neighborhood Hits	106	Target Neighborhood Hits	943	Shared Neighborhood Hits	83
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

NCAM2_MOUSE
θ value	9.29e-05 (rank : 17)	NC score	0.315323 (rank : 9)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	97
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

TITIN_HUMAN
θ value	0.00102713 (rank : 18)	NC score	0.190734 (rank : 136)
Query Neighborhood Hits	106	Target Neighborhood Hits	2923	Shared Neighborhood Hits	100
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MYPN_HUMAN
θ value	0.00228821 (rank : 19)	NC score	0.300200 (rank : 17)
Query Neighborhood Hits	106	Target Neighborhood Hits	418	Shared Neighborhood Hits	97
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NCAM2_HUMAN
θ value	0.00228821 (rank : 20)	NC score	0.312917 (rank : 10)
Query Neighborhood Hits	106	Target Neighborhood Hits	441	Shared Neighborhood Hits	98
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

ROBO3_MOUSE
θ value	0.00228821 (rank : 21)	NC score	0.264807 (rank : 29)
Query Neighborhood Hits	106	Target Neighborhood Hits	524	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

MYPN_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.299048 (rank : 19)
Query Neighborhood Hits	106	Target Neighborhood Hits	421	Shared Neighborhood Hits	95
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

PGBM_HUMAN
θ value	0.00390308 (rank : 23)	NC score	0.229849 (rank : 76)
Query Neighborhood Hits	106	Target Neighborhood Hits	1113	Shared Neighborhood Hits	98
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

HMCN1_HUMAN
θ value	0.00509761 (rank : 24)	NC score	0.231982 (rank : 74)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

OBSCN_HUMAN
θ value	0.00509761 (rank : 25)	NC score	0.150431 (rank : 201)
Query Neighborhood Hits	106	Target Neighborhood Hits	1931	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SDK2_MOUSE
θ value	0.00509761 (rank : 26)	NC score	0.236228 (rank : 60)
Query Neighborhood Hits	106	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

OBSL1_HUMAN
θ value	0.00869519 (rank : 27)	NC score	0.276736 (rank : 26)
Query Neighborhood Hits	106	Target Neighborhood Hits	354	Shared Neighborhood Hits	94
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ROR2_HUMAN
θ value	0.00869519 (rank : 28)	NC score	0.183966 (rank : 153)
Query Neighborhood Hits	106	Target Neighborhood Hits	1014	Shared Neighborhood Hits	91
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

DSCL1_HUMAN
θ value	0.0113563 (rank : 29)	NC score	0.283058 (rank : 24)
Query Neighborhood Hits	106	Target Neighborhood Hits	589	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

ROR2_MOUSE
θ value	0.0252991 (rank : 30)	NC score	0.187289 (rank : 144)
Query Neighborhood Hits	106	Target Neighborhood Hits	1000	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

DSCAM_HUMAN
θ value	0.0330416 (rank : 31)	NC score	0.271881 (rank : 27)
Query Neighborhood Hits	106	Target Neighborhood Hits	524	Shared Neighborhood Hits	98
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

CNTN6_HUMAN
θ value	0.0431538 (rank : 32)	NC score	0.235025 (rank : 66)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

SN_HUMAN
θ value	0.0431538 (rank : 33)	NC score	0.249477 (rank : 39)
Query Neighborhood Hits	106	Target Neighborhood Hits	434	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

PGBM_MOUSE
θ value	0.0736092 (rank : 34)	NC score	0.212532 (rank : 94)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	98
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

L1CAM_MOUSE
θ value	0.0961366 (rank : 35)	NC score	0.251252 (rank : 38)
Query Neighborhood Hits	106	Target Neighborhood Hits	457	Shared Neighborhood Hits	97
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LRRN1_HUMAN
θ value	0.125558 (rank : 36)	NC score	0.126328 (rank : 240)
Query Neighborhood Hits	106	Target Neighborhood Hits	518	Shared Neighborhood Hits	90
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

MYLK_MOUSE
θ value	0.125558 (rank : 37)	NC score	0.132815 (rank : 230)
Query Neighborhood Hits	106	Target Neighborhood Hits	1489	Shared Neighborhood Hits	97
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NEO1_MOUSE
θ value	0.125558 (rank : 38)	NC score	0.230265 (rank : 75)
Query Neighborhood Hits	106	Target Neighborhood Hits	523	Shared Neighborhood Hits	97
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

CNTN3_HUMAN
θ value	0.163984 (rank : 39)	NC score	0.235748 (rank : 64)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	98
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

GPA33_MOUSE
θ value	0.163984 (rank : 40)	NC score	0.184756 (rank : 148)
Query Neighborhood Hits	106	Target Neighborhood Hits	294	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

ROR1_HUMAN
θ value	0.163984 (rank : 41)	NC score	0.174062 (rank : 161)
Query Neighborhood Hits	106	Target Neighborhood Hits	1018	Shared Neighborhood Hits	93
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

LRRN1_MOUSE
θ value	0.21417 (rank : 42)	NC score	0.120674 (rank : 262)
Query Neighborhood Hits	106	Target Neighborhood Hits	508	Shared Neighborhood Hits	89
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

ROR1_MOUSE
θ value	0.21417 (rank : 43)	NC score	0.171942 (rank : 166)
Query Neighborhood Hits	106	Target Neighborhood Hits	1025	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

CNTN6_MOUSE
θ value	0.279714 (rank : 44)	NC score	0.237171 (rank : 58)
Query Neighborhood Hits	106	Target Neighborhood Hits	429	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

LRRN5_HUMAN
θ value	0.279714 (rank : 45)	NC score	0.109961 (rank : 330)
Query Neighborhood Hits	106	Target Neighborhood Hits	493	Shared Neighborhood Hits	86
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

NTRK2_HUMAN
θ value	0.279714 (rank : 46)	NC score	0.171571 (rank : 167)
Query Neighborhood Hits	106	Target Neighborhood Hits	1081	Shared Neighborhood Hits	95
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

CD166_MOUSE
θ value	0.365318 (rank : 47)	NC score	0.223052 (rank : 86)
Query Neighborhood Hits	106	Target Neighborhood Hits	252	Shared Neighborhood Hits	77
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

NTRK2_MOUSE
θ value	0.365318 (rank : 48)	NC score	0.170973 (rank : 169)
Query Neighborhood Hits	106	Target Neighborhood Hits	1088	Shared Neighborhood Hits	95
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

SDK2_HUMAN
θ value	0.365318 (rank : 49)	NC score	0.234518 (rank : 67)
Query Neighborhood Hits	106	Target Neighborhood Hits	495	Shared Neighborhood Hits	98
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CNTN5_MOUSE
θ value	0.47712 (rank : 50)	NC score	0.244082 (rank : 47)
Query Neighborhood Hits	106	Target Neighborhood Hits	434	Shared Neighborhood Hits	98
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

LRIG1_HUMAN
θ value	0.47712 (rank : 51)	NC score	0.192873 (rank : 131)
Query Neighborhood Hits	106	Target Neighborhood Hits	654	Shared Neighborhood Hits	97
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

NEO1_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.229471 (rank : 78)
Query Neighborhood Hits	106	Target Neighborhood Hits	530	Shared Neighborhood Hits	96
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

PTPRF_HUMAN
θ value	0.62314 (rank : 53)	NC score	0.163282 (rank : 185)
Query Neighborhood Hits	106	Target Neighborhood Hits	489	Shared Neighborhood Hits	97
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

SIG12_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.122413 (rank : 254)
Query Neighborhood Hits	106	Target Neighborhood Hits	245	Shared Neighborhood Hits	79
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

SN_MOUSE
θ value	0.62314 (rank : 55)	NC score	0.247400 (rank : 41)
Query Neighborhood Hits	106	Target Neighborhood Hits	416	Shared Neighborhood Hits	95
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

MAMC1_HUMAN
θ value	0.813845 (rank : 56)	NC score	0.264420 (rank : 30)
Query Neighborhood Hits	106	Target Neighborhood Hits	357	Shared Neighborhood Hits	97
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.265131 (rank : 28)
Query Neighborhood Hits	106	Target Neighborhood Hits	357	Shared Neighborhood Hits	97
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MFA3L_MOUSE
θ value	0.813845 (rank : 58)	NC score	0.192825 (rank : 132)
Query Neighborhood Hits	106	Target Neighborhood Hits	214	Shared Neighborhood Hits	82
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

LRIG1_MOUSE
θ value	1.06291 (rank : 59)	NC score	0.186031 (rank : 145)
Query Neighborhood Hits	106	Target Neighborhood Hits	627	Shared Neighborhood Hits	97
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MFA3L_HUMAN
θ value	1.06291 (rank : 60)	NC score	0.219406 (rank : 89)
Query Neighborhood Hits	106	Target Neighborhood Hits	230	Shared Neighborhood Hits	86
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

SIGL8_HUMAN
θ value	1.38821 (rank : 61)	NC score	0.135038 (rank : 228)
Query Neighborhood Hits	106	Target Neighborhood Hits	252	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

CD166_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.210631 (rank : 98)
Query Neighborhood Hits	106	Target Neighborhood Hits	247	Shared Neighborhood Hits	76
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CNTN3_MOUSE
θ value	1.81305 (rank : 63)	NC score	0.218978 (rank : 90)
Query Neighborhood Hits	106	Target Neighborhood Hits	447	Shared Neighborhood Hits	97
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

DCC_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.237330 (rank : 57)
Query Neighborhood Hits	106	Target Neighborhood Hits	583	Shared Neighborhood Hits	98
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

NCA11_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.298699 (rank : 20)
Query Neighborhood Hits	106	Target Neighborhood Hits	443	Shared Neighborhood Hits	98
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA11_MOUSE
θ value	1.81305 (rank : 66)	NC score	0.292756 (rank : 22)
Query Neighborhood Hits	106	Target Neighborhood Hits	661	Shared Neighborhood Hits	97
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.300289 (rank : 16)
Query Neighborhood Hits	106	Target Neighborhood Hits	437	Shared Neighborhood Hits	97
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA12_MOUSE
θ value	1.81305 (rank : 68)	NC score	0.300319 (rank : 15)
Query Neighborhood Hits	106	Target Neighborhood Hits	399	Shared Neighborhood Hits	97
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

SPEG_MOUSE
θ value	1.81305 (rank : 69)	NC score	0.137257 (rank : 224)
Query Neighborhood Hits	106	Target Neighborhood Hits	1959	Shared Neighborhood Hits	98
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

LRC24_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.087559 (rank : 405)
Query Neighborhood Hits	106	Target Neighborhood Hits	387	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

NPTN_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.208283 (rank : 99)
Query Neighborhood Hits	106	Target Neighborhood Hits	212	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

SPEG_HUMAN
θ value	2.36792 (rank : 72)	NC score	0.135592 (rank : 227)
Query Neighborhood Hits	106	Target Neighborhood Hits	1762	Shared Neighborhood Hits	98
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CHL1_MOUSE
θ value	3.0926 (rank : 73)	NC score	0.223044 (rank : 87)
Query Neighborhood Hits	106	Target Neighborhood Hits	402	Shared Neighborhood Hits	96
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

IGS4B_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.181304 (rank : 154)
Query Neighborhood Hits	106	Target Neighborhood Hits	328	Shared Neighborhood Hits	85
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

L1CAM_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.239003 (rank : 55)
Query Neighborhood Hits	106	Target Neighborhood Hits	457	Shared Neighborhood Hits	98
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

MYLK_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.132905 (rank : 229)
Query Neighborhood Hits	106	Target Neighborhood Hits	1328	Shared Neighborhood Hits	97
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CAN2_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.012358 (rank : 765)
Query Neighborhood Hits	106	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O08529, O35518, O54843	Gene names	Capn2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (80 kDa M-calpain subunit) (CALP80).

CNTN5_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.239853 (rank : 51)
Query Neighborhood Hits	106	Target Neighborhood Hits	446	Shared Neighborhood Hits	98
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN1_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.232835 (rank : 72)
Query Neighborhood Hits	106	Target Neighborhood Hits	431	Shared Neighborhood Hits	97
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.232696 (rank : 73)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	98
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN4_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.236209 (rank : 61)
Query Neighborhood Hits	106	Target Neighborhood Hits	449	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_MOUSE
θ value	5.27518 (rank : 82)	NC score	0.237911 (rank : 56)
Query Neighborhood Hits	106	Target Neighborhood Hits	445	Shared Neighborhood Hits	98
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

FCRL5_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.181003 (rank : 157)
Query Neighborhood Hits	106	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

MYOM1_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.199748 (rank : 112)
Query Neighborhood Hits	106	Target Neighborhood Hits	415	Shared Neighborhood Hits	88
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

NPBL_MOUSE
θ value	5.27518 (rank : 85)	NC score	0.007756 (rank : 769)
Query Neighborhood Hits	106	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

NRG2_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.189349 (rank : 140)
Query Neighborhood Hits	106	Target Neighborhood Hits	419	Shared Neighborhood Hits	86
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PTPRD_HUMAN
θ value	5.27518 (rank : 87)	NC score	0.159412 (rank : 190)
Query Neighborhood Hits	106	Target Neighborhood Hits	485	Shared Neighborhood Hits	94
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

ROBO2_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.239347 (rank : 53)
Query Neighborhood Hits	106	Target Neighborhood Hits	504	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CAN2_HUMAN
θ value	6.88961 (rank : 89)	NC score	0.009240 (rank : 766)
Query Neighborhood Hits	106	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	P17655, Q16738, Q6PJT3, Q8WU26, Q9HBB1	Gene names	CAPN2, CANPL2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2).

CI094_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.172001 (rank : 165)
Query Neighborhood Hits	106	Target Neighborhood Hits	310	Shared Neighborhood Hits	83
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CSMD2_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.004885 (rank : 770)
Query Neighborhood Hits	106	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

LRC24_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.085263 (rank : 412)
Query Neighborhood Hits	106	Target Neighborhood Hits	404	Shared Neighborhood Hits	77
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

NFKB2_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.008832 (rank : 768)
Query Neighborhood Hits	106	Target Neighborhood Hits	325	Shared Neighborhood Hits	5
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NFKB2_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.009106 (rank : 767)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NRG2_MOUSE
θ value	6.88961 (rank : 95)	NC score	0.184428 (rank : 149)
Query Neighborhood Hits	106	Target Neighborhood Hits	392	Shared Neighborhood Hits	86
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

DCC_MOUSE
θ value	8.99809 (rank : 96)	NC score	0.229543 (rank : 77)
Query Neighborhood Hits	106	Target Neighborhood Hits	896	Shared Neighborhood Hits	98
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

FGRL1_MOUSE
θ value	8.99809 (rank : 97)	NC score	0.257017 (rank : 32)
Query Neighborhood Hits	106	Target Neighborhood Hits	325	Shared Neighborhood Hits	97
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

JAML1_MOUSE
θ value	8.99809 (rank : 98)	NC score	0.079745 (rank : 431)
Query Neighborhood Hits	106	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

KIRR2_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.177753 (rank : 159)
Query Neighborhood Hits	106	Target Neighborhood Hits	321	Shared Neighborhood Hits	88
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

LSAMP_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.253452 (rank : 34)
Query Neighborhood Hits	106	Target Neighborhood Hits	347	Shared Neighborhood Hits	97
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_MOUSE
θ value	8.99809 (rank : 101)	NC score	0.251687 (rank : 37)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

PTPRD_MOUSE
θ value	8.99809 (rank : 102)	NC score	0.161785 (rank : 187)
Query Neighborhood Hits	106	Target Neighborhood Hits	491	Shared Neighborhood Hits	95
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.158420 (rank : 192)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	95
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

REL_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.016612 (rank : 763)
Query Neighborhood Hits	106	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

REL_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.016552 (rank : 764)
Query Neighborhood Hits	106	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

ROBO3_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.248299 (rank : 40)
Query Neighborhood Hits	106	Target Neighborhood Hits	570	Shared Neighborhood Hits	96
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

AAK1_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.057172 (rank : 615)
Query Neighborhood Hits	106	Target Neighborhood Hits	1077	Shared Neighborhood Hits	26
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.057725 (rank : 602)
Query Neighborhood Hits	106	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAPK1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.050609 (rank : 749)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.050361 (rank : 755)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.119177 (rank : 270)
Query Neighborhood Hits	106	Target Neighborhood Hits	1243	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.121591 (rank : 259)
Query Neighborhood Hits	106	Target Neighborhood Hits	942	Shared Neighborhood Hits	27
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.109767 (rank : 333)
Query Neighborhood Hits	106	Target Neighborhood Hits	1220	Shared Neighborhood Hits	27
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.109400 (rank : 334)
Query Neighborhood Hits	106	Target Neighborhood Hits	1178	Shared Neighborhood Hits	28
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.110890 (rank : 325)
Query Neighborhood Hits	106	Target Neighborhood Hits	1045	Shared Neighborhood Hits	26
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.123208 (rank : 252)
Query Neighborhood Hits	106	Target Neighborhood Hits	1140	Shared Neighborhood Hits	27
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.123965 (rank : 248)
Query Neighborhood Hits	106	Target Neighborhood Hits	1080	Shared Neighborhood Hits	27
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACVL1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.061369 (rank : 548)
Query Neighborhood Hits	106	Target Neighborhood Hits	716	Shared Neighborhood Hits	21
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.062834 (rank : 533)
Query Neighborhood Hits	106	Target Neighborhood Hits	739	Shared Neighborhood Hits	22
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.051532 (rank : 727)
Query Neighborhood Hits	106	Target Neighborhood Hits	760	Shared Neighborhood Hits	25
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.051973 (rank : 719)
Query Neighborhood Hits	106	Target Neighborhood Hits	768	Shared Neighborhood Hits	25
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AL2S7_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.052512 (rank : 710)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.136624 (rank : 225)
Query Neighborhood Hits	106	Target Neighborhood Hits	795	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.137395 (rank : 223)
Query Neighborhood Hits	106	Target Neighborhood Hits	811	Shared Neighborhood Hits	27
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.050292 (rank : 758)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	21
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.063077 (rank : 529)
Query Neighborhood Hits	106	Target Neighborhood Hits	1075	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.066700 (rank : 493)
Query Neighborhood Hits	106	Target Neighborhood Hits	1072	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.077374 (rank : 444)
Query Neighborhood Hits	106	Target Neighborhood Hits	612	Shared Neighborhood Hits	22
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.072651 (rank : 467)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	22
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.069576 (rank : 479)
Query Neighborhood Hits	106	Target Neighborhood Hits	646	Shared Neighborhood Hits	21
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.067674 (rank : 489)
Query Neighborhood Hits	106	Target Neighborhood Hits	607	Shared Neighborhood Hits	21
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.084158 (rank : 420)
Query Neighborhood Hits	106	Target Neighborhood Hits	924	Shared Neighborhood Hits	26
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.084226 (rank : 418)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ATL3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.145132 (rank : 209)
Query Neighborhood Hits	106	Target Neighborhood Hits	414	Shared Neighborhood Hits	92
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

BASI_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.188493 (rank : 142)
Query Neighborhood Hits	106	Target Neighborhood Hits	211	Shared Neighborhood Hits	82
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

BASI_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.198150 (rank : 116)
Query Neighborhood Hits	106	Target Neighborhood Hits	238	Shared Neighborhood Hits	89
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

BLK_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.111435 (rank : 319)
Query Neighborhood Hits	106	Target Neighborhood Hits	994	Shared Neighborhood Hits	26
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.111493 (rank : 318)
Query Neighborhood Hits	106	Target Neighborhood Hits	992	Shared Neighborhood Hits	26
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMP2K_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.054662 (rank : 669)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.051438 (rank : 730)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMPR2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.051948 (rank : 721)
Query Neighborhood Hits	106	Target Neighborhood Hits	736	Shared Neighborhood Hits	23
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMR1A_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.052455 (rank : 714)
Query Neighborhood Hits	106	Target Neighborhood Hits	759	Shared Neighborhood Hits	25
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.052468 (rank : 713)
Query Neighborhood Hits	106	Target Neighborhood Hits	758	Shared Neighborhood Hits	25
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.053355 (rank : 693)
Query Neighborhood Hits	106	Target Neighborhood Hits	760	Shared Neighborhood Hits	23
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.056778 (rank : 624)
Query Neighborhood Hits	106	Target Neighborhood Hits	758	Shared Neighborhood Hits	23
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.112028 (rank : 317)
Query Neighborhood Hits	106	Target Neighborhood Hits	942	Shared Neighborhood Hits	26
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.112661 (rank : 312)
Query Neighborhood Hits	106	Target Neighborhood Hits	912	Shared Neighborhood Hits	26
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BOC_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.235781 (rank : 62)
Query Neighborhood Hits	106	Target Neighborhood Hits	543	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.233916 (rank : 70)
Query Neighborhood Hits	106	Target Neighborhood Hits	433	Shared Neighborhood Hits	95
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BRAF1_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.081797 (rank : 428)
Query Neighborhood Hits	106	Target Neighborhood Hits	883	Shared Neighborhood Hits	26
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BTK_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.107282 (rank : 346)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	26
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.107246 (rank : 347)
Query Neighborhood Hits	106	Target Neighborhood Hits	1017	Shared Neighborhood Hits	26
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CCRK_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.058241 (rank : 594)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.056537 (rank : 629)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD22_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.198363 (rank : 115)
Query Neighborhood Hits	106	Target Neighborhood Hits	365	Shared Neighborhood Hits	83
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD22_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.184949 (rank : 147)
Query Neighborhood Hits	106	Target Neighborhood Hits	331	Shared Neighborhood Hits	87
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD276_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.083630 (rank : 422)
Query Neighborhood Hits	106	Target Neighborhood Hits	261	Shared Neighborhood Hits	51
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

CD276_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.059676 (rank : 570)
Query Neighborhood Hits	106	Target Neighborhood Hits	243	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD2L5_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.056849 (rank : 620)
Query Neighborhood Hits	106	Target Neighborhood Hits	987	Shared Neighborhood Hits	27
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.056806 (rank : 622)
Query Neighborhood Hits	106	Target Neighborhood Hits	1011	Shared Neighborhood Hits	27
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.058881 (rank : 580)
Query Neighborhood Hits	106	Target Neighborhood Hits	1275	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD4_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.072421 (rank : 470)
Query Neighborhood Hits	106	Target Neighborhood Hits	122	Shared Neighborhood Hits	32
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CD79A_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.076171 (rank : 451)
Query Neighborhood Hits	106	Target Neighborhood Hits	102	Shared Neighborhood Hits	37
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD80_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.082676 (rank : 425)
Query Neighborhood Hits	106	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CD80_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.103760 (rank : 367)
Query Neighborhood Hits	106	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CDC2_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.051653 (rank : 724)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.051268 (rank : 737)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.051364 (rank : 733)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.053742 (rank : 682)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK4_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.064188 (rank : 524)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.061983 (rank : 544)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.065689 (rank : 503)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.065924 (rank : 502)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.065438 (rank : 505)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.065246 (rank : 509)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.053490 (rank : 690)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.053645 (rank : 684)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDKL1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.059309 (rank : 574)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.055994 (rank : 640)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.065315 (rank : 508)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.058890 (rank : 579)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.060469 (rank : 561)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.057598 (rank : 607)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.056865 (rank : 618)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.057310 (rank : 611)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.057696 (rank : 603)
Query Neighborhood Hits	106	Target Neighborhood Hits	967	Shared Neighborhood Hits	26
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CDON_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.246401 (rank : 42)
Query Neighborhood Hits	106	Target Neighborhood Hits	412	Shared Neighborhood Hits	96
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.239898 (rank : 50)
Query Neighborhood Hits	106	Target Neighborhood Hits	410	Shared Neighborhood Hits	95
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CEA20_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.168551 (rank : 177)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	69
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

CEAM1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.175188 (rank : 160)
Query Neighborhood Hits	106	Target Neighborhood Hits	348	Shared Neighborhood Hits	82
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

CEAM1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.189836 (rank : 139)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	90
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

CEAM5_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.193962 (rank : 128)
Query Neighborhood Hits	106	Target Neighborhood Hits	343	Shared Neighborhood Hits	90
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CEAM6_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.141045 (rank : 214)
Query Neighborhood Hits	106	Target Neighborhood Hits	308	Shared Neighborhood Hits	88
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CEAM7_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.075981 (rank : 453)
Query Neighborhood Hits	106	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

CEAM8_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.118089 (rank : 279)
Query Neighborhood Hits	106	Target Neighborhood Hits	264	Shared Neighborhood Hits	79
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

CHL1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.213147 (rank : 93)
Query Neighborhood Hits	106	Target Neighborhood Hits	413	Shared Neighborhood Hits	94
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CI096_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.055938 (rank : 645)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CILP1_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.103552 (rank : 370)
Query Neighborhood Hits	106	Target Neighborhood Hits	266	Shared Neighborhood Hits	69
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP1_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.106883 (rank : 350)
Query Neighborhood Hits	106	Target Neighborhood Hits	282	Shared Neighborhood Hits	73
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP2_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.111001 (rank : 323)
Query Neighborhood Hits	106	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CNTN2_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.235588 (rank : 65)
Query Neighborhood Hits	106	Target Neighborhood Hits	440	Shared Neighborhood Hits	97
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.236321 (rank : 59)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	97
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CSK_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.113527 (rank : 309)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.110928 (rank : 324)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CXAR_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.111133 (rank : 321)
Query Neighborhood Hits	106	Target Neighborhood Hits	245	Shared Neighborhood Hits	57
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CXAR_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.097646 (rank : 382)
Query Neighborhood Hits	106	Target Neighborhood Hits	250	Shared Neighborhood Hits	59
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

DAPK2_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.056044 (rank : 639)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.055444 (rank : 654)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.053921 (rank : 679)
Query Neighborhood Hits	106	Target Neighborhood Hits	945	Shared Neighborhood Hits	26
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.053252 (rank : 697)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DDR1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.132223 (rank : 231)
Query Neighborhood Hits	106	Target Neighborhood Hits	819	Shared Neighborhood Hits	27
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.136528 (rank : 226)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	27
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.126158 (rank : 241)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	26
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.127192 (rank : 239)
Query Neighborhood Hits	106	Target Neighborhood Hits	813	Shared Neighborhood Hits	26
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DUET_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.079522 (rank : 432)
Query Neighborhood Hits	106	Target Neighborhood Hits	1220	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

E2AK1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.074885 (rank : 458)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.072432 (rank : 469)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.077630 (rank : 443)
Query Neighborhood Hits	106	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.065624 (rank : 504)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.082827 (rank : 424)
Query Neighborhood Hits	106	Target Neighborhood Hits	859	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.083525 (rank : 423)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK4_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.050112 (rank : 761)
Query Neighborhood Hits	106	Target Neighborhood Hits	1012	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.120870 (rank : 261)
Query Neighborhood Hits	106	Target Neighborhood Hits	939	Shared Neighborhood Hits	27
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.120969 (rank : 260)
Query Neighborhood Hits	106	Target Neighborhood Hits	927	Shared Neighborhood Hits	28
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMB_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.074097 (rank : 460)
Query Neighborhood Hits	106	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

EMB_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.116607 (rank : 290)
Query Neighborhood Hits	106	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

EPHA1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.115906 (rank : 293)
Query Neighborhood Hits	106	Target Neighborhood Hits	997	Shared Neighborhood Hits	50
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.116774 (rank : 289)
Query Neighborhood Hits	106	Target Neighborhood Hits	958	Shared Neighborhood Hits	52
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.118414 (rank : 274)
Query Neighborhood Hits	106	Target Neighborhood Hits	1021	Shared Neighborhood Hits	58
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.119036 (rank : 272)
Query Neighborhood Hits	106	Target Neighborhood Hits	1020	Shared Neighborhood Hits	59
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.117765 (rank : 283)
Query Neighborhood Hits	106	Target Neighborhood Hits	1005	Shared Neighborhood Hits	64
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.117744 (rank : 284)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.116920 (rank : 287)
Query Neighborhood Hits	106	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.117379 (rank : 286)
Query Neighborhood Hits	106	Target Neighborhood Hits	982	Shared Neighborhood Hits	58
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.115796 (rank : 296)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.119259 (rank : 269)
Query Neighborhood Hits	106	Target Neighborhood Hits	950	Shared Neighborhood Hits	57
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.123655 (rank : 250)
Query Neighborhood Hits	106	Target Neighborhood Hits	959	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.121613 (rank : 258)
Query Neighborhood Hits	106	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.118605 (rank : 273)
Query Neighborhood Hits	106	Target Neighborhood Hits	1053	Shared Neighborhood Hits	59
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.118217 (rank : 278)
Query Neighborhood Hits	106	Target Neighborhood Hits	1025	Shared Neighborhood Hits	58
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.118026 (rank : 281)
Query Neighborhood Hits	106	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.118246 (rank : 276)
Query Neighborhood Hits	106	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.112126 (rank : 315)
Query Neighborhood Hits	106	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.115395 (rank : 301)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	56
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.114572 (rank : 304)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.114617 (rank : 303)
Query Neighborhood Hits	106	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.119291 (rank : 268)
Query Neighborhood Hits	106	Target Neighborhood Hits	996	Shared Neighborhood Hits	61
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.119779 (rank : 265)
Query Neighborhood Hits	106	Target Neighborhood Hits	996	Shared Neighborhood Hits	60
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.118038 (rank : 280)
Query Neighborhood Hits	106	Target Neighborhood Hits	1056	Shared Neighborhood Hits	61
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.118223 (rank : 277)
Query Neighborhood Hits	106	Target Neighborhood Hits	1013	Shared Neighborhood Hits	63
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.113694 (rank : 308)
Query Neighborhood Hits	106	Target Neighborhood Hits	912	Shared Neighborhood Hits	63
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.114906 (rank : 302)
Query Neighborhood Hits	106	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.122119 (rank : 257)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	27
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.122250 (rank : 256)
Query Neighborhood Hits	106	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.125342 (rank : 244)
Query Neighborhood Hits	106	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.125564 (rank : 243)
Query Neighborhood Hits	106	Target Neighborhood Hits	898	Shared Neighborhood Hits	26
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.117872 (rank : 282)
Query Neighborhood Hits	106	Target Neighborhood Hits	910	Shared Neighborhood Hits	28
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERN1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.053530 (rank : 688)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.055664 (rank : 649)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ESAM_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.118412 (rank : 275)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	67
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

ESAM_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.091180 (rank : 399)
Query Neighborhood Hits	106	Target Neighborhood Hits	222	Shared Neighborhood Hits	63
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FAK1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.119335 (rank : 267)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.119159 (rank : 271)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.123940 (rank : 249)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.122664 (rank : 253)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FCERA_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.084763 (rank : 414)
Query Neighborhood Hits	106	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCERA_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.062679 (rank : 537)
Query Neighborhood Hits	106	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCGR1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.055290 (rank : 658)
Query Neighborhood Hits	106	Target Neighborhood Hits	145	Shared Neighborhood Hits	45
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

FCRL2_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.166816 (rank : 180)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	74
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

FER_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.116196 (rank : 291)
Query Neighborhood Hits	106	Target Neighborhood Hits	1278	Shared Neighborhood Hits	26
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.115543 (rank : 300)
Query Neighborhood Hits	106	Target Neighborhood Hits	978	Shared Neighborhood Hits	26
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.115701 (rank : 299)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.195749 (rank : 121)
Query Neighborhood Hits	106	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.195624 (rank : 122)
Query Neighborhood Hits	106	Target Neighborhood Hits	1068	Shared Neighborhood Hits	93
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.194242 (rank : 126)
Query Neighborhood Hits	106	Target Neighborhood Hits	1062	Shared Neighborhood Hits	91
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.192697 (rank : 133)
Query Neighborhood Hits	106	Target Neighborhood Hits	1062	Shared Neighborhood Hits	91
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.195245 (rank : 123)
Query Neighborhood Hits	106	Target Neighborhood Hits	1042	Shared Neighborhood Hits	91
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.197011 (rank : 119)
Query Neighborhood Hits	106	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.195014 (rank : 124)
Query Neighborhood Hits	106	Target Neighborhood Hits	1037	Shared Neighborhood Hits	94
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.198496 (rank : 114)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FGRL1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.246162 (rank : 43)
Query Neighborhood Hits	106	Target Neighborhood Hits	335	Shared Neighborhood Hits	96
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGR_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.105696 (rank : 359)
Query Neighborhood Hits	106	Target Neighborhood Hits	1067	Shared Neighborhood Hits	26
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.107313 (rank : 345)
Query Neighborhood Hits	106	Target Neighborhood Hits	1069	Shared Neighborhood Hits	26
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FINC_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.064765 (rank : 515)
Query Neighborhood Hits	106	Target Neighborhood Hits	302	Shared Neighborhood Hits	42
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

FINC_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.067611 (rank : 490)
Query Neighborhood Hits	106	Target Neighborhood Hits	309	Shared Neighborhood Hits	41
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FLT3_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.233495 (rank : 71)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.239114 (rank : 54)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FNDC3_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.101238 (rank : 374)
Query Neighborhood Hits	106	Target Neighborhood Hits	196	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.100532 (rank : 378)
Query Neighborhood Hits	106	Target Neighborhood Hits	207	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FRK_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.108389 (rank : 342)
Query Neighborhood Hits	106	Target Neighborhood Hits	1058	Shared Neighborhood Hits	26
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FSTL4_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.211105 (rank : 97)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	95
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.207162 (rank : 102)
Query Neighborhood Hits	106	Target Neighborhood Hits	333	Shared Neighborhood Hits	93
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL5_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.194002 (rank : 127)
Query Neighborhood Hits	106	Target Neighborhood Hits	347	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL5_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.197534 (rank : 117)
Query Neighborhood Hits	106	Target Neighborhood Hits	355	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

FYN_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.104937 (rank : 363)
Query Neighborhood Hits	106	Target Neighborhood Hits	1078	Shared Neighborhood Hits	26
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.106003 (rank : 355)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	26
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.051010 (rank : 742)
Query Neighborhood Hits	106	Target Neighborhood Hits	1028	Shared Neighborhood Hits	26
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GAK_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.053307 (rank : 694)
Query Neighborhood Hits	106	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GPA33_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.143669 (rank : 210)
Query Neighborhood Hits	106	Target Neighborhood Hits	273	Shared Neighborhood Hits	62
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

GRK4_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.054125 (rank : 676)
Query Neighborhood Hits	106	Target Neighborhood Hits	822	Shared Neighborhood Hits	26
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.053638 (rank : 685)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK6_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.051534 (rank : 726)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.050773 (rank : 747)
Query Neighborhood Hits	106	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GSK3A_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.058201 (rank : 596)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	24
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.057650 (rank : 604)
Query Neighborhood Hits	106	Target Neighborhood Hits	801	Shared Neighborhood Hits	24
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.057649 (rank : 605)
Query Neighborhood Hits	106	Target Neighborhood Hits	800	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GUC2C_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.097349 (rank : 384)
Query Neighborhood Hits	106	Target Neighborhood Hits	624	Shared Neighborhood Hits	23
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.069346 (rank : 480)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.070897 (rank : 474)
Query Neighborhood Hits	106	Target Neighborhood Hits	692	Shared Neighborhood Hits	25
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.090773 (rank : 400)
Query Neighborhood Hits	106	Target Neighborhood Hits	740	Shared Neighborhood Hits	25
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.051527 (rank : 728)
Query Neighborhood Hits	106	Target Neighborhood Hits	644	Shared Neighborhood Hits	24
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCK_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.112784 (rank : 311)
Query Neighborhood Hits	106	Target Neighborhood Hits	1035	Shared Neighborhood Hits	26
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.113167 (rank : 310)
Query Neighborhood Hits	106	Target Neighborhood Hits	1029	Shared Neighborhood Hits	26
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HHLA2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.054745 (rank : 667)
Query Neighborhood Hits	106	Target Neighborhood Hits	140	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

IBP7_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.129891 (rank : 234)
Query Neighborhood Hits	106	Target Neighborhood Hits	220	Shared Neighborhood Hits	70
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.130254 (rank : 233)
Query Neighborhood Hits	106	Target Neighborhood Hits	230	Shared Neighborhood Hits	70
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

ICAM1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.055002 (rank : 663)
Query Neighborhood Hits	106	Target Neighborhood Hits	99	Shared Neighborhood Hits	39
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ICAM5_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.170318 (rank : 170)
Query Neighborhood Hits	106	Target Neighborhood Hits	276	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

ICAM5_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.172322 (rank : 164)
Query Neighborhood Hits	106	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

ICK_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.061574 (rank : 546)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.060520 (rank : 560)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IGF1R_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.138313 (rank : 221)
Query Neighborhood Hits	106	Target Neighborhood Hits	977	Shared Neighborhood Hits	46
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.139755 (rank : 216)
Query Neighborhood Hits	106	Target Neighborhood Hits	973	Shared Neighborhood Hits	46
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGS21_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.062751 (rank : 536)
Query Neighborhood Hits	106	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS21_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.065222 (rank : 510)
Query Neighborhood Hits	106	Target Neighborhood Hits	118	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS4B_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.166842 (rank : 179)
Query Neighborhood Hits	106	Target Neighborhood Hits	305	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

IGSF2_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.066622 (rank : 494)
Query Neighborhood Hits	106	Target Neighborhood Hits	208	Shared Neighborhood Hits	39
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

IKKA_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.058891 (rank : 578)
Query Neighborhood Hits	106	Target Neighborhood Hits	863	Shared Neighborhood Hits	26
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.059180 (rank : 576)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.053400 (rank : 692)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.053215 (rank : 698)
Query Neighborhood Hits	106	Target Neighborhood Hits	984	Shared Neighborhood Hits	26
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IL1R1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.077682 (rank : 442)
Query Neighborhood Hits	106	Target Neighborhood Hits	140	Shared Neighborhood Hits	53
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IL1R1_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.072668 (rank : 466)
Query Neighborhood Hits	106	Target Neighborhood Hits	142	Shared Neighborhood Hits	55
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

IL1R2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.152768 (rank : 200)
Query Neighborhood Hits	106	Target Neighborhood Hits	153	Shared Neighborhood Hits	60
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

IL1R2_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.105921 (rank : 357)
Query Neighborhood Hits	106	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

IL6RB_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.056409 (rank : 632)
Query Neighborhood Hits	106	Target Neighborhood Hits	181	Shared Neighborhood Hits	35
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IL6RB_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.050303 (rank : 757)
Query Neighborhood Hits	106	Target Neighborhood Hits	168	Shared Neighborhood Hits	36
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.077207 (rank : 445)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.073237 (rank : 463)
Query Neighborhood Hits	106	Target Neighborhood Hits	848	Shared Neighborhood Hits	26
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.078406 (rank : 437)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.067532 (rank : 491)
Query Neighborhood Hits	106	Target Neighborhood Hits	167	Shared Neighborhood Hits	49
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

ILRL1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.058462 (rank : 589)
Query Neighborhood Hits	106	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

ILRL2_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.091647 (rank : 395)
Query Neighborhood Hits	106	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

INSRR_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.138561 (rank : 219)
Query Neighborhood Hits	106	Target Neighborhood Hits	950	Shared Neighborhood Hits	47
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.140781 (rank : 215)
Query Neighborhood Hits	106	Target Neighborhood Hits	961	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.138376 (rank : 220)
Query Neighborhood Hits	106	Target Neighborhood Hits	963	Shared Neighborhood Hits	42
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.138765 (rank : 218)
Query Neighborhood Hits	106	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK4_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.076505 (rank : 449)
Query Neighborhood Hits	106	Target Neighborhood Hits	816	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.072486 (rank : 468)
Query Neighborhood Hits	106	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

IRPL1_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.095071 (rank : 390)
Query Neighborhood Hits	106	Target Neighborhood Hits	196	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

IRPL1_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.095587 (rank : 387)
Query Neighborhood Hits	106	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

IRPL2_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.103563 (rank : 369)
Query Neighborhood Hits	106	Target Neighborhood Hits	194	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL2_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.101827 (rank : 373)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

ITB4_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.051263 (rank : 738)
Query Neighborhood Hits	106	Target Neighborhood Hits	458	Shared Neighborhood Hits	37
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

ITK_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.109146 (rank : 336)
Query Neighborhood Hits	106	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.110199 (rank : 328)
Query Neighborhood Hits	106	Target Neighborhood Hits	985	Shared Neighborhood Hits	26
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.108722 (rank : 339)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.109783 (rank : 332)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.106001 (rank : 356)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.105921 (rank : 358)
Query Neighborhood Hits	106	Target Neighborhood Hits	839	Shared Neighborhood Hits	26
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.114145 (rank : 306)
Query Neighborhood Hits	106	Target Neighborhood Hits	827	Shared Neighborhood Hits	26
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.107968 (rank : 343)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JAM1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.197197 (rank : 118)
Query Neighborhood Hits	106	Target Neighborhood Hits	294	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

JAM1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.184111 (rank : 152)
Query Neighborhood Hits	106	Target Neighborhood Hits	287	Shared Neighborhood Hits	81
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

JAM2_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.207358 (rank : 101)
Query Neighborhood Hits	106	Target Neighborhood Hits	304	Shared Neighborhood Hits	88
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JAM2_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.189958 (rank : 138)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JAM3_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.169594 (rank : 173)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

JAM3_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.181289 (rank : 156)
Query Neighborhood Hits	106	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

KAZD1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.130364 (rank : 232)
Query Neighborhood Hits	106	Target Neighborhood Hits	248	Shared Neighborhood Hits	70
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.149837 (rank : 202)
Query Neighborhood Hits	106	Target Neighborhood Hits	281	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KGP1A_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.051368 (rank : 732)
Query Neighborhood Hits	106	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.051316 (rank : 735)
Query Neighborhood Hits	106	Target Neighborhood Hits	921	Shared Neighborhood Hits	26
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.051314 (rank : 736)
Query Neighborhood Hits	106	Target Neighborhood Hits	922	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KIRR1_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.192165 (rank : 134)
Query Neighborhood Hits	106	Target Neighborhood Hits	401	Shared Neighborhood Hits	86
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR1_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.184182 (rank : 151)
Query Neighborhood Hits	106	Target Neighborhood Hits	403	Shared Neighborhood Hits	86
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR2_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.173273 (rank : 163)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

KIRR3_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.167559 (rank : 178)
Query Neighborhood Hits	106	Target Neighborhood Hits	302	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

KIRR3_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.169762 (rank : 172)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

KKCC1_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.051394 (rank : 731)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.050570 (rank : 750)
Query Neighborhood Hits	106	Target Neighborhood Hits	866	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.055159 (rank : 661)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.055121 (rank : 662)
Query Neighborhood Hits	106	Target Neighborhood Hits	855	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.050165 (rank : 760)
Query Neighborhood Hits	106	Target Neighborhood Hits	1067	Shared Neighborhood Hits	26
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.051901 (rank : 722)
Query Neighborhood Hits	106	Target Neighborhood Hits	1121	Shared Neighborhood Hits	26
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.052148 (rank : 716)
Query Neighborhood Hits	106	Target Neighborhood Hits	1117	Shared Neighborhood Hits	26
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.059929 (rank : 567)
Query Neighborhood Hits	106	Target Neighborhood Hits	900	Shared Neighborhood Hits	26
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.059275 (rank : 575)
Query Neighborhood Hits	106	Target Neighborhood Hits	888	Shared Neighborhood Hits	26
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.055376 (rank : 656)
Query Neighborhood Hits	106	Target Neighborhood Hits	897	Shared Neighborhood Hits	26
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.054689 (rank : 668)
Query Neighborhood Hits	106	Target Neighborhood Hits	895	Shared Neighborhood Hits	26
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KS6A1_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.054160 (rank : 674)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.053914 (rank : 680)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.052853 (rank : 705)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.054321 (rank : 672)
Query Neighborhood Hits	106	Target Neighborhood Hits	859	Shared Neighborhood Hits	26
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.054313 (rank : 673)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.051987 (rank : 718)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KSR1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.078981 (rank : 434)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.077058 (rank : 447)
Query Neighborhood Hits	106	Target Neighborhood Hits	870	Shared Neighborhood Hits	28
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.068075 (rank : 485)
Query Neighborhood Hits	106	Target Neighborhood Hits	920	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.115896 (rank : 294)
Query Neighborhood Hits	106	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.115759 (rank : 298)
Query Neighborhood Hits	106	Target Neighborhood Hits	944	Shared Neighborhood Hits	26
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAG3_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.056944 (rank : 616)
Query Neighborhood Hits	106	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LCK_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.110083 (rank : 329)
Query Neighborhood Hits	106	Target Neighborhood Hits	987	Shared Neighborhood Hits	26
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.108907 (rank : 337)
Query Neighborhood Hits	106	Target Neighborhood Hits	981	Shared Neighborhood Hits	26
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIFR_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.050400 (rank : 754)
Query Neighborhood Hits	106	Target Neighborhood Hits	130	Shared Neighborhood Hits	28
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

LIMK1_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.078121 (rank : 439)
Query Neighborhood Hits	106	Target Neighborhood Hits	1005	Shared Neighborhood Hits	26
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.079392 (rank : 433)
Query Neighborhood Hits	106	Target Neighborhood Hits	1008	Shared Neighborhood Hits	27
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.067904 (rank : 487)
Query Neighborhood Hits	106	Target Neighborhood Hits	986	Shared Neighborhood Hits	26
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.067690 (rank : 488)
Query Neighborhood Hits	106	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRC21_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.095174 (rank : 389)
Query Neighborhood Hits	106	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRC21_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.095439 (rank : 388)
Query Neighborhood Hits	106	Target Neighborhood Hits	462	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRC4B_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.073515 (rank : 462)
Query Neighborhood Hits	106	Target Neighborhood Hits	479	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.074338 (rank : 459)
Query Neighborhood Hits	106	Target Neighborhood Hits	484	Shared Neighborhood Hits	87
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRFN2_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.111394 (rank : 320)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.112589 (rank : 313)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	86
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN3_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.089326 (rank : 401)
Query Neighborhood Hits	106	Target Neighborhood Hits	444	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRFN3_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.097263 (rank : 385)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRFN4_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.098778 (rank : 380)
Query Neighborhood Hits	106	Target Neighborhood Hits	462	Shared Neighborhood Hits	84
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN4_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.099002 (rank : 379)
Query Neighborhood Hits	106	Target Neighborhood Hits	442	Shared Neighborhood Hits	84
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN5_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.100986 (rank : 375)
Query Neighborhood Hits	106	Target Neighborhood Hits	464	Shared Neighborhood Hits	88
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRFN5_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.103837 (rank : 366)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRIG2_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.181298 (rank : 155)
Query Neighborhood Hits	106	Target Neighborhood Hits	595	Shared Neighborhood Hits	95
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG2_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.179330 (rank : 158)
Query Neighborhood Hits	106	Target Neighborhood Hits	586	Shared Neighborhood Hits	95
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRIG3_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.164046 (rank : 183)
Query Neighborhood Hits	106	Target Neighborhood Hits	601	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

LRIG3_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.169070 (rank : 175)
Query Neighborhood Hits	106	Target Neighborhood Hits	611	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

LRRC4_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.066083 (rank : 500)
Query Neighborhood Hits	106	Target Neighborhood Hits	444	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

LRRC4_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.057220 (rank : 612)
Query Neighborhood Hits	106	Target Neighborhood Hits	412	Shared Neighborhood Hits	73
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

LRRK1_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.080956 (rank : 430)
Query Neighborhood Hits	106	Target Neighborhood Hits	1237	Shared Neighborhood Hits	33
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.078791 (rank : 435)
Query Neighborhood Hits	106	Target Neighborhood Hits	1267	Shared Neighborhood Hits	33
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.066375 (rank : 497)
Query Neighborhood Hits	106	Target Neighborhood Hits	1382	Shared Neighborhood Hits	31
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.065966 (rank : 501)
Query Neighborhood Hits	106	Target Neighborhood Hits	1359	Shared Neighborhood Hits	30
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRRN3_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.102233 (rank : 372)
Query Neighborhood Hits	106	Target Neighborhood Hits	461	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LRRN3_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.097604 (rank : 383)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LTK_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.139377 (rank : 217)
Query Neighborhood Hits	106	Target Neighborhood Hits	774	Shared Neighborhood Hits	27
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.141419 (rank : 213)
Query Neighborhood Hits	106	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LU_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.207695 (rank : 100)
Query Neighborhood Hits	106	Target Neighborhood Hits	283	Shared Neighborhood Hits	92
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

LYN_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.108410 (rank : 341)
Query Neighborhood Hits	106	Target Neighborhood Hits	1022	Shared Neighborhood Hits	26
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.108565 (rank : 340)
Query Neighborhood Hits	106	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.092128 (rank : 394)
Query Neighborhood Hits	106	Target Neighborhood Hits	1071	Shared Neighborhood Hits	27
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.094539 (rank : 392)
Query Neighborhood Hits	106	Target Neighborhood Hits	1136	Shared Neighborhood Hits	27
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.091424 (rank : 396)
Query Neighborhood Hits	106	Target Neighborhood Hits	940	Shared Neighborhood Hits	26
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.091412 (rank : 397)
Query Neighborhood Hits	106	Target Neighborhood Hits	957	Shared Neighborhood Hits	26
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.086814 (rank : 408)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.050735 (rank : 748)
Query Neighborhood Hits	106	Target Neighborhood Hits	914	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.054972 (rank : 665)
Query Neighborhood Hits	106	Target Neighborhood Hits	952	Shared Neighborhood Hits	28
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K3_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.050227 (rank : 759)
Query Neighborhood Hits	106	Target Neighborhood Hits	885	Shared Neighborhood Hits	27
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.053687 (rank : 683)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.051897 (rank : 723)
Query Neighborhood Hits	106	Target Neighborhood Hits	924	Shared Neighborhood Hits	26
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K7_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.085515 (rank : 410)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.084966 (rank : 413)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.054761 (rank : 666)
Query Neighborhood Hits	106	Target Neighborhood Hits	807	Shared Neighborhood Hits	24
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.052713 (rank : 706)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	24
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.092870 (rank : 393)
Query Neighborhood Hits	106	Target Neighborhood Hits	1123	Shared Neighborhood Hits	26
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.097652 (rank : 381)
Query Neighborhood Hits	106	Target Neighborhood Hits	1087	Shared Neighborhood Hits	26
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K4_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.052928 (rank : 704)
Query Neighborhood Hits	106	Target Neighborhood Hits	1589	Shared Neighborhood Hits	27
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.057195 (rank : 613)
Query Neighborhood Hits	106	Target Neighborhood Hits	1560	Shared Neighborhood Hits	27
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAG_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.211814 (rank : 95)
Query Neighborhood Hits	106	Target Neighborhood Hits	278	Shared Neighborhood Hits	90
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.211777 (rank : 96)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	89
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAK_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.064391 (rank : 521)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.063754 (rank : 525)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MALT1_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.195004 (rank : 125)
Query Neighborhood Hits	106	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MATK_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.120071 (rank : 263)
Query Neighborhood Hits	106	Target Neighborhood Hits	954	Shared Neighborhood Hits	26
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.119341 (rank : 266)
Query Neighborhood Hits	106	Target Neighborhood Hits	952	Shared Neighborhood Hits	26
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MDGA1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.257611 (rank : 31)
Query Neighborhood Hits	106	Target Neighborhood Hits	358	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MERTK_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.163759 (rank : 184)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	86
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.160816 (rank : 188)
Query Neighborhood Hits	106	Target Neighborhood Hits	974	Shared Neighborhood Hits	82
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.128920 (rank : 237)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	25
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.129290 (rank : 236)
Query Neighborhood Hits	106	Target Neighborhood Hits	844	Shared Neighborhood Hits	25
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MFAP3_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.066980 (rank : 492)
Query Neighborhood Hits	106	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.055771 (rank : 648)
Query Neighborhood Hits	106	Target Neighborhood Hits	97	Shared Neighborhood Hits	37
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MINK1_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.056304 (rank : 634)
Query Neighborhood Hits	106	Target Neighborhood Hits	1477	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.056203 (rank : 636)
Query Neighborhood Hits	106	Target Neighborhood Hits	1451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.066290 (rank : 499)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.066312 (rank : 498)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.063728 (rank : 526)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.064250 (rank : 523)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.059499 (rank : 571)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	24
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.060454 (rank : 562)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	25
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.055452 (rank : 653)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	24
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.055616 (rank : 650)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	24
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.054992 (rank : 664)
Query Neighborhood Hits	106	Target Neighborhood Hits	1087	Shared Neighborhood Hits	26
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.055271 (rank : 659)
Query Neighborhood Hits	106	Target Neighborhood Hits	1054	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK11_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.053079 (rank : 701)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK14_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.050976 (rank : 743)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.050818 (rank : 745)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK15_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.053853 (rank : 681)
Query Neighborhood Hits	106	Target Neighborhood Hits	1038	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK15_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.053200 (rank : 699)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MLKL_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.075316 (rank : 456)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.072890 (rank : 464)
Query Neighborhood Hits	106	Target Neighborhood Hits	707	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.094952 (rank : 391)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.095603 (rank : 386)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOK_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.062139 (rank : 543)
Query Neighborhood Hits	106	Target Neighborhood Hits	807	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.061152 (rank : 553)
Query Neighborhood Hits	106	Target Neighborhood Hits	796	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOS_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.084393 (rank : 417)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.086776 (rank : 409)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOX2R_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.071093 (rank : 473)
Query Neighborhood Hits	106	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MP2K1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.055977 (rank : 642)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.056080 (rank : 637)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.058318 (rank : 592)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.057596 (rank : 608)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.062488 (rank : 539)
Query Neighborhood Hits	106	Target Neighborhood Hits	825	Shared Neighborhood Hits	26
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.061385 (rank : 547)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.065030 (rank : 512)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.064957 (rank : 513)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.068723 (rank : 481)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.074995 (rank : 457)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.061180 (rank : 551)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.060295 (rank : 566)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.062763 (rank : 535)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.062998 (rank : 530)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.062815 (rank : 534)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUC18_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.192139 (rank : 135)
Query Neighborhood Hits	106	Target Neighborhood Hits	275	Shared Neighborhood Hits	81
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

MUC18_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.203606 (rank : 106)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MUSK_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.201556 (rank : 109)
Query Neighborhood Hits	106	Target Neighborhood Hits	1074	Shared Neighborhood Hits	95
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.202822 (rank : 107)
Query Neighborhood Hits	106	Target Neighborhood Hits	1057	Shared Neighborhood Hits	93
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYBPH_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.192993 (rank : 130)
Query Neighborhood Hits	106	Target Neighborhood Hits	256	Shared Neighborhood Hits	87
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYBPH_MOUSE
θ value	θ > 10 (rank : 516)	NC score	0.187558 (rank : 143)
Query Neighborhood Hits	106	Target Neighborhood Hits	290	Shared Neighborhood Hits	85
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYLK2_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.058537 (rank : 587)
Query Neighborhood Hits	106	Target Neighborhood Hits	920	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYOM1_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.184274 (rank : 150)
Query Neighborhood Hits	106	Target Neighborhood Hits	405	Shared Neighborhood Hits	87
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.189019 (rank : 141)
Query Neighborhood Hits	106	Target Neighborhood Hits	341	Shared Neighborhood Hits	85
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOTI_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.252908 (rank : 35)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.245236 (rank : 45)
Query Neighborhood Hits	106	Target Neighborhood Hits	297	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC1_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.193108 (rank : 129)
Query Neighborhood Hits	106	Target Neighborhood Hits	303	Shared Neighborhood Hits	85
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYPC2_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.190435 (rank : 137)
Query Neighborhood Hits	106	Target Neighborhood Hits	316	Shared Neighborhood Hits	89
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.185151 (rank : 146)
Query Neighborhood Hits	106	Target Neighborhood Hits	297	Shared Neighborhood Hits	87
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC3_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.173451 (rank : 162)
Query Neighborhood Hits	106	Target Neighborhood Hits	318	Shared Neighborhood Hits	83
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.171439 (rank : 168)
Query Neighborhood Hits	106	Target Neighborhood Hits	310	Shared Neighborhood Hits	80
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NEGR1_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.228225 (rank : 80)
Query Neighborhood Hits	106	Target Neighborhood Hits	346	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NEGR1_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.224378 (rank : 84)
Query Neighborhood Hits	106	Target Neighborhood Hits	349	Shared Neighborhood Hits	96
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NEK11_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.064421 (rank : 520)
Query Neighborhood Hits	106	Target Neighborhood Hits	1043	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.064535 (rank : 517)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.053528 (rank : 689)
Query Neighborhood Hits	106	Target Neighborhood Hits	1129	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.053971 (rank : 678)
Query Neighborhood Hits	106	Target Neighborhood Hits	1311	Shared Neighborhood Hits	26
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.060899 (rank : 556)
Query Neighborhood Hits	106	Target Neighborhood Hits	908	Shared Neighborhood Hits	26
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.053300 (rank : 696)
Query Neighborhood Hits	106	Target Neighborhood Hits	876	Shared Neighborhood Hits	26
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.056856 (rank : 619)
Query Neighborhood Hits	106	Target Neighborhood Hits	865	Shared Neighborhood Hits	26
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.053145 (rank : 700)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.065436 (rank : 506)
Query Neighborhood Hits	106	Target Neighborhood Hits	883	Shared Neighborhood Hits	26
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.065095 (rank : 511)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.064451 (rank : 519)
Query Neighborhood Hits	106	Target Neighborhood Hits	848	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.064643 (rank : 516)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.068511 (rank : 482)
Query Neighborhood Hits	106	Target Neighborhood Hits	846	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.068068 (rank : 486)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.054369 (rank : 671)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.054585 (rank : 670)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.063432 (rank : 527)
Query Neighborhood Hits	106	Target Neighborhood Hits	900	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 546)	NC score	0.062179 (rank : 542)
Query Neighborhood Hits	106	Target Neighborhood Hits	890	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NFASC_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.223363 (rank : 85)
Query Neighborhood Hits	106	Target Neighborhood Hits	497	Shared Neighborhood Hits	96
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.226995 (rank : 82)
Query Neighborhood Hits	106	Target Neighborhood Hits	475	Shared Neighborhood Hits	96
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NGL1_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.075825 (rank : 454)
Query Neighborhood Hits	106	Target Neighborhood Hits	511	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.076092 (rank : 452)
Query Neighborhood Hits	106	Target Neighborhood Hits	512	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NLK_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.060693 (rank : 558)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.060692 (rank : 559)
Query Neighborhood Hits	106	Target Neighborhood Hits	839	Shared Neighborhood Hits	26
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NPHN_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.198589 (rank : 113)
Query Neighborhood Hits	106	Target Neighborhood Hits	362	Shared Neighborhood Hits	90
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NPHN_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.196599 (rank : 120)
Query Neighborhood Hits	106	Target Neighborhood Hits	370	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NPTN_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.200963 (rank : 110)
Query Neighborhood Hits	106	Target Neighborhood Hits	216	Shared Neighborhood Hits	80
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

NRCAM_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.213631 (rank : 92)
Query Neighborhood Hits	106	Target Neighborhood Hits	439	Shared Neighborhood Hits	95
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.221159 (rank : 88)
Query Neighborhood Hits	106	Target Neighborhood Hits	432	Shared Neighborhood Hits	96
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NRG1_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.142259 (rank : 211)
Query Neighborhood Hits	106	Target Neighborhood Hits	285	Shared Neighborhood Hits	68
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NRK_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.061161 (rank : 552)
Query Neighborhood Hits	106	Target Neighborhood Hits	931	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.061256 (rank : 549)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NTRI_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.241254 (rank : 49)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	96
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NTRI_MOUSE
θ value	θ > 10 (rank : 562)	NC score	0.243777 (rank : 48)
Query Neighborhood Hits	106	Target Neighborhood Hits	342	Shared Neighborhood Hits	96
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

NTRK1_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.149277 (rank : 203)
Query Neighborhood Hits	106	Target Neighborhood Hits	1023	Shared Neighborhood Hits	70
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK3_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.163107 (rank : 186)
Query Neighborhood Hits	106	Target Neighborhood Hits	1115	Shared Neighborhood Hits	90
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OPCM_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.251984 (rank : 36)
Query Neighborhood Hits	106	Target Neighborhood Hits	332	Shared Neighborhood Hits	96
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

OX2G_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.057176 (rank : 614)
Query Neighborhood Hits	106	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OX2G_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.064321 (rank : 522)
Query Neighborhood Hits	106	Target Neighborhood Hits	105	Shared Neighborhood Hits	38
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

OXSR1_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.060748 (rank : 557)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.060322 (rank : 565)
Query Neighborhood Hits	106	Target Neighborhood Hits	865	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.057872 (rank : 600)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	28
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.058130 (rank : 598)
Query Neighborhood Hits	106	Target Neighborhood Hits	878	Shared Neighborhood Hits	28
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.056272 (rank : 635)
Query Neighborhood Hits	106	Target Neighborhood Hits	862	Shared Neighborhood Hits	26
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.056445 (rank : 631)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.055806 (rank : 647)
Query Neighborhood Hits	106	Target Neighborhood Hits	887	Shared Neighborhood Hits	26
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.055881 (rank : 646)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK6_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.056586 (rank : 628)
Query Neighborhood Hits	106	Target Neighborhood Hits	915	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 577)	NC score	0.053043 (rank : 703)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.052489 (rank : 712)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PCTK1_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.055162 (rank : 660)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.055348 (rank : 657)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	27
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.058458 (rank : 590)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.058354 (rank : 591)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.054144 (rank : 675)
Query Neighborhood Hits	106	Target Neighborhood Hits	827	Shared Neighborhood Hits	26
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.055972 (rank : 643)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.056062 (rank : 638)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.056732 (rank : 626)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDL1_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.091213 (rank : 398)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL1_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.078572 (rank : 436)
Query Neighborhood Hits	106	Target Neighborhood Hits	168	Shared Neighborhood Hits	52
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDL2_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.084677 (rank : 415)
Query Neighborhood Hits	106	Target Neighborhood Hits	116	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDPK1_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.050026 (rank : 762)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PECA1_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.119810 (rank : 264)
Query Neighborhood Hits	106	Target Neighborhood Hits	178	Shared Neighborhood Hits	60
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PECA1_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.081897 (rank : 427)
Query Neighborhood Hits	106	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

PFTK1_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.052129 (rank : 717)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.052382 (rank : 715)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PIGR_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.081960 (rank : 426)
Query Neighborhood Hits	106	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PIGR_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.100794 (rank : 377)
Query Neighborhood Hits	106	Target Neighborhood Hits	214	Shared Neighborhood Hits	53
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PIM2_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.050784 (rank : 746)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PINK1_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.056489 (rank : 630)
Query Neighborhood Hits	106	Target Neighborhood Hits	726	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.062987 (rank : 531)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.062526 (rank : 538)
Query Neighborhood Hits	106	Target Neighborhood Hits	888	Shared Neighborhood Hits	26
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.058505 (rank : 588)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.058292 (rank : 593)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.053556 (rank : 686)
Query Neighborhood Hits	106	Target Neighborhood Hits	893	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.053982 (rank : 677)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.060416 (rank : 563)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.058647 (rank : 585)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.051635 (rank : 725)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.051205 (rank : 740)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.055568 (rank : 651)
Query Neighborhood Hits	106	Target Neighborhood Hits	884	Shared Neighborhood Hits	28
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.055961 (rank : 644)
Query Neighborhood Hits	106	Target Neighborhood Hits	879	Shared Neighborhood Hits	26
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PRP4B_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.061194 (rank : 550)
Query Neighborhood Hits	106	Target Neighborhood Hits	1030	Shared Neighborhood Hits	27
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.060979 (rank : 554)
Query Neighborhood Hits	106	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PSG10_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.107142 (rank : 348)
Query Neighborhood Hits	106	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG11_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.111039 (rank : 322)
Query Neighborhood Hits	106	Target Neighborhood Hits	223	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG1_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.117443 (rank : 285)
Query Neighborhood Hits	106	Target Neighborhood Hits	232	Shared Neighborhood Hits	75
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG2_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.114364 (rank : 305)
Query Neighborhood Hits	106	Target Neighborhood Hits	229	Shared Neighborhood Hits	78
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

PSG3_HUMAN
θ value	θ > 10 (rank : 617)	NC score	0.122368 (rank : 255)
Query Neighborhood Hits	106	Target Neighborhood Hits	242	Shared Neighborhood Hits	76
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

PSG4_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.124336 (rank : 247)
Query Neighborhood Hits	106	Target Neighborhood Hits	243	Shared Neighborhood Hits	74
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

PSG5_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.110632 (rank : 326)
Query Neighborhood Hits	106	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

PSG6_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.108827 (rank : 338)
Query Neighborhood Hits	106	Target Neighborhood Hits	231	Shared Neighborhood Hits	75
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PSG7_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.113860 (rank : 307)
Query Neighborhood Hits	106	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PSG8_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.124815 (rank : 246)
Query Neighborhood Hits	106	Target Neighborhood Hits	239	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG9_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.104571 (rank : 365)
Query Neighborhood Hits	106	Target Neighborhood Hits	221	Shared Neighborhood Hits	69
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

PTK6_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.112542 (rank : 314)
Query Neighborhood Hits	106	Target Neighborhood Hits	1020	Shared Neighborhood Hits	26
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.115788 (rank : 297)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	26
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTK7_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.202269 (rank : 108)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	96
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PUNC_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.234106 (rank : 68)
Query Neighborhood Hits	106	Target Neighborhood Hits	449	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.234100 (rank : 69)
Query Neighborhood Hits	106	Target Neighborhood Hits	501	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PVRL1_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.069857 (rank : 478)
Query Neighborhood Hits	106	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PVRL1_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.072764 (rank : 465)
Query Neighborhood Hits	106	Target Neighborhood Hits	201	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL2_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.078057 (rank : 440)
Query Neighborhood Hits	106	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVRL2_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.077757 (rank : 441)
Query Neighborhood Hits	106	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVRL3_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.102396 (rank : 371)
Query Neighborhood Hits	106	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PVRL3_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.100852 (rank : 376)
Query Neighborhood Hits	106	Target Neighborhood Hits	212	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PVR_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.071874 (rank : 472)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	46
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

RAF1_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.083969 (rank : 421)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.084586 (rank : 416)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAGE_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.204425 (rank : 105)
Query Neighborhood Hits	106	Target Neighborhood Hits	269	Shared Neighborhood Hits	85
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RAGE_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.206212 (rank : 103)
Query Neighborhood Hits	106	Target Neighborhood Hits	295	Shared Neighborhood Hits	83
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RET_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.156731 (rank : 196)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.157799 (rank : 194)
Query Neighborhood Hits	106	Target Neighborhood Hits	884	Shared Neighborhood Hits	29
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.085477 (rank : 411)
Query Neighborhood Hits	106	Target Neighborhood Hits	891	Shared Neighborhood Hits	26
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.088620 (rank : 403)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.057866 (rank : 601)
Query Neighborhood Hits	106	Target Neighborhood Hits	774	Shared Neighborhood Hits	25
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.062901 (rank : 532)
Query Neighborhood Hits	106	Target Neighborhood Hits	776	Shared Neighborhood Hits	26
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.078316 (rank : 438)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.060399 (rank : 564)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.060945 (rank : 555)
Query Neighborhood Hits	106	Target Neighborhood Hits	1094	Shared Neighborhood Hits	27
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.105109 (rank : 362)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.104633 (rank : 364)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RK_MOUSE
θ value	θ > 10 (rank : 651)	NC score	0.053531 (rank : 687)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROBO1_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.245579 (rank : 44)
Query Neighborhood Hits	106	Target Neighborhood Hits	529	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.245206 (rank : 46)
Query Neighborhood Hits	106	Target Neighborhood Hits	559	Shared Neighborhood Hits	96
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.235756 (rank : 63)
Query Neighborhood Hits	106	Target Neighborhood Hits	479	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO4_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.200612 (rank : 111)
Query Neighborhood Hits	106	Target Neighborhood Hits	364	Shared Neighborhood Hits	82
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

ROBO4_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.205910 (rank : 104)
Query Neighborhood Hits	106	Target Neighborhood Hits	358	Shared Neighborhood Hits	79
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

RON_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.127723 (rank : 238)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	25
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.129324 (rank : 235)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	25
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROS_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.145623 (rank : 207)
Query Neighborhood Hits	106	Target Neighborhood Hits	907	Shared Neighborhood Hits	60
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.146681 (rank : 206)
Query Neighborhood Hits	106	Target Neighborhood Hits	701	Shared Neighborhood Hits	24
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 661)	NC score	0.145253 (rank : 208)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	24
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SCYL2_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.076294 (rank : 450)
Query Neighborhood Hits	106	Target Neighborhood Hits	632	Shared Neighborhood Hits	24
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.076527 (rank : 448)
Query Neighborhood Hits	106	Target Neighborhood Hits	603	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SDK1_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.229350 (rank : 79)
Query Neighborhood Hits	106	Target Neighborhood Hits	511	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.228215 (rank : 81)
Query Neighborhood Hits	106	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SHPS1_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.059853 (rank : 569)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	46
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SIG10_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.168726 (rank : 176)
Query Neighborhood Hits	106	Target Neighborhood Hits	363	Shared Neighborhood Hits	81
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

SIG11_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.165019 (rank : 182)
Query Neighborhood Hits	106	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

SIG12_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.106061 (rank : 354)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

SIGL5_HUMAN
θ value	θ > 10 (rank : 670)	NC score	0.123243 (rank : 251)
Query Neighborhood Hits	106	Target Neighborhood Hits	246	Shared Neighborhood Hits	70
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

SIGL5_MOUSE
θ value	θ > 10 (rank : 671)	NC score	0.157610 (rank : 195)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	90
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

SIGL6_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.110222 (rank : 327)
Query Neighborhood Hits	106	Target Neighborhood Hits	233	Shared Neighborhood Hits	76
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

SIGL7_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.084193 (rank : 419)
Query Neighborhood Hits	106	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

SIRB1_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.057380 (rank : 609)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	41
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

SLK_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.050355 (rank : 756)
Query Neighborhood Hits	106	Target Neighborhood Hits	1775	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SRC_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.106670 (rank : 351)
Query Neighborhood Hits	106	Target Neighborhood Hits	1058	Shared Neighborhood Hits	26
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 677)	NC score	0.107525 (rank : 344)
Query Neighborhood Hits	106	Target Neighborhood Hits	1033	Shared Neighborhood Hits	26
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.116916 (rank : 288)
Query Neighborhood Hits	106	Target Neighborhood Hits	946	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 679)	NC score	0.115857 (rank : 295)
Query Neighborhood Hits	106	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17A_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.056705 (rank : 627)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.051214 (rank : 739)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.052530 (rank : 709)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK10_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.051972 (rank : 720)
Query Neighborhood Hits	106	Target Neighborhood Hits	1921	Shared Neighborhood Hits	28
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.050965 (rank : 744)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK24_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.064778 (rank : 514)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.064489 (rank : 518)
Query Neighborhood Hits	106	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.062289 (rank : 540)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.062235 (rank : 541)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK35_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.058770 (rank : 583)
Query Neighborhood Hits	106	Target Neighborhood Hits	825	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.059439 (rank : 572)
Query Neighborhood Hits	106	Target Neighborhood Hits	896	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.058695 (rank : 584)
Query Neighborhood Hits	106	Target Neighborhood Hits	877	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.058881 (rank : 581)
Query Neighborhood Hits	106	Target Neighborhood Hits	882	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.058791 (rank : 582)
Query Neighborhood Hits	106	Target Neighborhood Hits	915	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.056769 (rank : 625)
Query Neighborhood Hits	106	Target Neighborhood Hits	861	Shared Neighborhood Hits	26
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.057317 (rank : 610)
Query Neighborhood Hits	106	Target Neighborhood Hits	869	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.056393 (rank : 633)
Query Neighborhood Hits	106	Target Neighborhood Hits	870	Shared Neighborhood Hits	26
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.056786 (rank : 623)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.052561 (rank : 708)
Query Neighborhood Hits	106	Target Neighborhood Hits	916	Shared Neighborhood Hits	26
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STYK1_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.137670 (rank : 222)
Query Neighborhood Hits	106	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.141771 (rank : 212)
Query Neighborhood Hits	106	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK1_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.050497 (rank : 752)
Query Neighborhood Hits	106	Target Neighborhood Hits	1734	Shared Neighborhood Hits	27
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 702)	NC score	0.050407 (rank : 753)
Query Neighborhood Hits	106	Target Neighborhood Hits	1720	Shared Neighborhood Hits	27
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.057621 (rank : 606)
Query Neighborhood Hits	106	Target Neighborhood Hits	1172	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.055990 (rank : 641)
Query Neighborhood Hits	106	Target Neighborhood Hits	1373	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.051452 (rank : 729)
Query Neighborhood Hits	106	Target Neighborhood Hits	1494	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.050503 (rank : 751)
Query Neighborhood Hits	106	Target Neighborhood Hits	1458	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TEC_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.106901 (rank : 349)
Query Neighborhood Hits	106	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.105603 (rank : 361)
Query Neighborhood Hits	106	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.071902 (rank : 471)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.070127 (rank : 477)
Query Neighborhood Hits	106	Target Neighborhood Hits	862	Shared Neighborhood Hits	27
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.081737 (rank : 429)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.077059 (rank : 446)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.063372 (rank : 528)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.070222 (rank : 476)
Query Neighborhood Hits	106	Target Neighborhood Hits	1333	Shared Neighborhood Hits	25
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR2_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.061616 (rank : 545)
Query Neighborhood Hits	106	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.058959 (rank : 577)
Query Neighborhood Hits	106	Target Neighborhood Hits	748	Shared Neighborhood Hits	26
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TIE1_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.153411 (rank : 199)
Query Neighborhood Hits	106	Target Neighborhood Hits	1241	Shared Neighborhood Hits	73
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.153557 (rank : 198)
Query Neighborhood Hits	106	Target Neighborhood Hits	1266	Shared Neighborhood Hits	77
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.148529 (rank : 204)
Query Neighborhood Hits	106	Target Neighborhood Hits	1192	Shared Neighborhood Hits	65
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.148440 (rank : 205)
Query Neighborhood Hits	106	Target Neighborhood Hits	1204	Shared Neighborhood Hits	65
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TMIGD_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.216622 (rank : 91)
Query Neighborhood Hits	106	Target Neighborhood Hits	240	Shared Neighborhood Hits	83
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TMIGD_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.226095 (rank : 83)
Query Neighborhood Hits	106	Target Neighborhood Hits	234	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TNI3K_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.073528 (rank : 461)
Query Neighborhood Hits	106	Target Neighborhood Hits	1084	Shared Neighborhood Hits	27
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.075467 (rank : 455)
Query Neighborhood Hits	106	Target Neighborhood Hits	1079	Shared Neighborhood Hits	28
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.053461 (rank : 691)
Query Neighborhood Hits	106	Target Neighborhood Hits	1570	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.125861 (rank : 242)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	26
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.125184 (rank : 245)
Query Neighborhood Hits	106	Target Neighborhood Hits	806	Shared Neighborhood Hits	27
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.087548 (rank : 406)
Query Neighborhood Hits	106	Target Neighborhood Hits	605	Shared Neighborhood Hits	22
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.087806 (rank : 404)
Query Neighborhood Hits	106	Target Neighborhood Hits	618	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.070675 (rank : 475)
Query Neighborhood Hits	106	Target Neighborhood Hits	1580	Shared Neighborhood Hits	93
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TTK_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.068133 (rank : 484)
Query Neighborhood Hits	106	Target Neighborhood Hits	816	Shared Neighborhood Hits	26
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.068391 (rank : 483)
Query Neighborhood Hits	106	Target Neighborhood Hits	803	Shared Neighborhood Hits	26
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TXK_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.109261 (rank : 335)
Query Neighborhood Hits	106	Target Neighborhood Hits	971	Shared Neighborhood Hits	26
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 734)	NC score	0.109817 (rank : 331)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.103597 (rank : 368)
Query Neighborhood Hits	106	Target Neighborhood Hits	841	Shared Neighborhood Hits	26
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.105661 (rank : 360)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.170274 (rank : 171)
Query Neighborhood Hits	106	Target Neighborhood Hits	995	Shared Neighborhood Hits	87
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.169395 (rank : 174)
Query Neighborhood Hits	106	Target Neighborhood Hits	1007	Shared Neighborhood Hits	88
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.156206 (rank : 197)
Query Neighborhood Hits	106	Target Neighborhood Hits	981	Shared Neighborhood Hits	78
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.157831 (rank : 193)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	83
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

UHMK1_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.066377 (rank : 496)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.066604 (rank : 495)
Query Neighborhood Hits	106	Target Neighborhood Hits	809	Shared Neighborhood Hits	24
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.053304 (rank : 695)
Query Neighborhood Hits	106	Target Neighborhood Hits	1121	Shared Neighborhood Hits	27
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.052576 (rank : 707)
Query Neighborhood Hits	106	Target Neighborhood Hits	1214	Shared Neighborhood Hits	27
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.055441 (rank : 655)
Query Neighborhood Hits	106	Target Neighborhood Hits	979	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.055452 (rank : 652)
Query Neighborhood Hits	106	Target Neighborhood Hits	943	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.058190 (rank : 597)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.056893 (rank : 617)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

UNC5A_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.059416 (rank : 573)
Query Neighborhood Hits	106	Target Neighborhood Hits	198	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.052496 (rank : 711)
Query Neighborhood Hits	106	Target Neighborhood Hits	203	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5B_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.053055 (rank : 702)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.051360 (rank : 734)
Query Neighborhood Hits	106	Target Neighborhood Hits	226	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5C_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.058554 (rank : 586)
Query Neighborhood Hits	106	Target Neighborhood Hits	226	Shared Neighborhood Hits	57
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.058230 (rank : 595)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5D_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.087270 (rank : 407)
Query Neighborhood Hits	106	Target Neighborhood Hits	267	Shared Neighborhood Hits	73
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.089151 (rank : 402)
Query Neighborhood Hits	106	Target Neighborhood Hits	268	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

USH2A_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.059911 (rank : 568)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.056843 (rank : 621)
Query Neighborhood Hits	106	Target Neighborhood Hits	626	Shared Neighborhood Hits	43
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VCAM1_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.255898 (rank : 33)
Query Neighborhood Hits	106	Target Neighborhood Hits	352	Shared Neighborhood Hits	92
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

VCAM1_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.239464 (rank : 52)
Query Neighborhood Hits	106	Target Neighborhood Hits	320	Shared Neighborhood Hits	90
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

VSIG2_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.159657 (rank : 189)
Query Neighborhood Hits	106	Target Neighborhood Hits	321	Shared Neighborhood Hits	86
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

VSIG2_MOUSE
θ value	θ > 10 (rank : 762)	NC score	0.158613 (rank : 191)
Query Neighborhood Hits	106	Target Neighborhood Hits	316	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

VSIG4_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.166473 (rank : 181)
Query Neighborhood Hits	106	Target Neighborhood Hits	236	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

WEE1_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.051170 (rank : 741)
Query Neighborhood Hits	106	Target Neighborhood Hits	777	Shared Neighborhood Hits	22
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WEE1_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.058015 (rank : 599)
Query Neighborhood Hits	106	Target Neighborhood Hits	794	Shared Neighborhood Hits	26
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

YES_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.106390 (rank : 353)
Query Neighborhood Hits	106	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.106493 (rank : 352)
Query Neighborhood Hits	106	Target Neighborhood Hits	1052	Shared Neighborhood Hits	26
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.065328 (rank : 507)
Query Neighborhood Hits	106	Target Neighborhood Hits	921	Shared Neighborhood Hits	26
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.112086 (rank : 316)
Query Neighborhood Hits	106	Target Neighborhood Hits	893	Shared Neighborhood Hits	26
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.116144 (rank : 292)
Query Neighborhood Hits	106	Target Neighborhood Hits	905	Shared Neighborhood Hits	26
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

PGFRL_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	106	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PGFRL_HUMAN
NC score	0.986898 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	106	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

VGFR1_HUMAN
NC score	0.336544 (rank : 3)	θ value	5.07402e-19 (rank : 4)
Query Neighborhood Hits	106	Target Neighborhood Hits	1109	Shared Neighborhood Hits	97
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
NC score	0.333338 (rank : 4)	θ value	5.99374e-20 (rank : 3)
Query Neighborhood Hits	106	Target Neighborhood Hits	1118	Shared Neighborhood Hits	98
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
NC score	0.331126 (rank : 5)	θ value	6.41864e-14 (rank : 7)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	98
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
NC score	0.328401 (rank : 6)	θ value	1.52774e-15 (rank : 5)
Query Neighborhood Hits	106	Target Neighborhood Hits	1089	Shared Neighborhood Hits	96
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_MOUSE
NC score	0.322212 (rank : 7)	θ value	1.58096e-12 (rank : 11)
Query Neighborhood Hits	106	Target Neighborhood Hits	1056	Shared Neighborhood Hits	94
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_HUMAN
NC score	0.321263 (rank : 8)	θ value	7.09661e-13 (rank : 10)
Query Neighborhood Hits	106	Target Neighborhood Hits	1037	Shared Neighborhood Hits	94
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

NCAM2_MOUSE
NC score	0.315323 (rank : 9)	θ value	9.29e-05 (rank : 17)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	97
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCAM2_HUMAN
NC score	0.312917 (rank : 10)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	106	Target Neighborhood Hits	441	Shared Neighborhood Hits	98
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

PGFRB_MOUSE
NC score	0.312551 (rank : 11)	θ value	1.42992e-13 (rank : 9)
Query Neighborhood Hits	106	Target Neighborhood Hits	960	Shared Neighborhood Hits	81
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRA_MOUSE
NC score	0.312416 (rank : 12)	θ value	3.76295e-14 (rank : 6)
Query Neighborhood Hits	106	Target Neighborhood Hits	975	Shared Neighborhood Hits	84
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
NC score	0.309712 (rank : 13)	θ value	1.42992e-13 (rank : 8)
Query Neighborhood Hits	106	Target Neighborhood Hits	962	Shared Neighborhood Hits	81
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRA_HUMAN
NC score	0.308827 (rank : 14)	θ value	2.0648e-12 (rank : 12)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	86
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

NCA12_MOUSE
NC score	0.300319 (rank : 15)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	106	Target Neighborhood Hits	399	Shared Neighborhood Hits	97
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA12_HUMAN
NC score	0.300289 (rank : 16)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	106	Target Neighborhood Hits	437	Shared Neighborhood Hits	97
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

MYPN_HUMAN
NC score	0.300200 (rank : 17)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	106	Target Neighborhood Hits	418	Shared Neighborhood Hits	97
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

KIT_MOUSE
NC score	0.299223 (rank : 18)	θ value	8.67504e-11 (rank : 13)
Query Neighborhood Hits	106	Target Neighborhood Hits	949	Shared Neighborhood Hits	85
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MYPN_MOUSE
NC score	0.299048 (rank : 19)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	106	Target Neighborhood Hits	421	Shared Neighborhood Hits	95
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCA11_HUMAN
NC score	0.298699 (rank : 20)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	106	Target Neighborhood Hits	443	Shared Neighborhood Hits	98
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

KIT_HUMAN
NC score	0.293512 (rank : 21)	θ value	9.59137e-10 (rank : 14)
Query Neighborhood Hits	106	Target Neighborhood Hits	953	Shared Neighborhood Hits	86
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

NCA11_MOUSE
NC score	0.292756 (rank : 22)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	106	Target Neighborhood Hits	661	Shared Neighborhood Hits	97
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CSF1R_MOUSE
NC score	0.288436 (rank : 23)	θ value	1.87187e-05 (rank : 15)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	89
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DSCL1_HUMAN
NC score	0.283058 (rank : 24)	θ value	0.0113563 (rank : 29)
Query Neighborhood Hits	106	Target Neighborhood Hits	589	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

CSF1R_HUMAN
NC score	0.283031 (rank : 25)	θ value	7.1131e-05 (rank : 16)
Query Neighborhood Hits	106	Target Neighborhood Hits	943	Shared Neighborhood Hits	83
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

OBSL1_HUMAN
NC score	0.276736 (rank : 26)	θ value	0.00869519 (rank : 27)
Query Neighborhood Hits	106	Target Neighborhood Hits	354	Shared Neighborhood Hits	94
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

DSCAM_HUMAN
NC score	0.271881 (rank : 27)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	106	Target Neighborhood Hits	524	Shared Neighborhood Hits	98
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

MAMC1_MOUSE
NC score	0.265131 (rank : 28)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	106	Target Neighborhood Hits	357	Shared Neighborhood Hits	97
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ROBO3_MOUSE
NC score	0.264807 (rank : 29)	θ value	0.00228821 (rank : 21)
Query Neighborhood Hits	106	Target Neighborhood Hits	524	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

MAMC1_HUMAN
NC score	0.264420 (rank : 30)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	106	Target Neighborhood Hits	357	Shared Neighborhood Hits	97
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MDGA1_HUMAN
NC score	0.257611 (rank : 31)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	106	Target Neighborhood Hits	358	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

FGRL1_MOUSE
NC score	0.257017 (rank : 32)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	106	Target Neighborhood Hits	325	Shared Neighborhood Hits	97
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

VCAM1_HUMAN
NC score	0.255898 (rank : 33)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	106	Target Neighborhood Hits	352	Shared Neighborhood Hits	92
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

LSAMP_HUMAN
NC score	0.253452 (rank : 34)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	106	Target Neighborhood Hits	347	Shared Neighborhood Hits	97
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYOTI_HUMAN
NC score	0.252908 (rank : 35)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

OPCM_HUMAN
NC score	0.251984 (rank : 36)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	106	Target Neighborhood Hits	332	Shared Neighborhood Hits	96
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

LSAMP_MOUSE
NC score	0.251687 (rank : 37)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

L1CAM_MOUSE
NC score	0.251252 (rank : 38)	θ value	0.0961366 (rank : 35)
Query Neighborhood Hits	106	Target Neighborhood Hits	457	Shared Neighborhood Hits	97
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

SN_HUMAN
NC score	0.249477 (rank : 39)	θ value	0.0431538 (rank : 33)
Query Neighborhood Hits	106	Target Neighborhood Hits	434	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

ROBO3_HUMAN
NC score	0.248299 (rank : 40)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	106	Target Neighborhood Hits	570	Shared Neighborhood Hits	96
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

SN_MOUSE
NC score	0.247400 (rank : 41)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	106	Target Neighborhood Hits	416	Shared Neighborhood Hits	95
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

CDON_HUMAN
NC score	0.246401 (rank : 42)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	106	Target Neighborhood Hits	412	Shared Neighborhood Hits	96
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

FGRL1_HUMAN
NC score	0.246162 (rank : 43)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	106	Target Neighborhood Hits	335	Shared Neighborhood Hits	96
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

ROBO1_HUMAN
NC score	0.245579 (rank : 44)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	106	Target Neighborhood Hits	529	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

MYOTI_MOUSE
NC score	0.245236 (rank : 45)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	106	Target Neighborhood Hits	297	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

ROBO1_MOUSE
NC score	0.245206 (rank : 46)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	106	Target Neighborhood Hits	559	Shared Neighborhood Hits	96
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

CNTN5_MOUSE
NC score	0.244082 (rank : 47)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	106	Target Neighborhood Hits	434	Shared Neighborhood Hits	98
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

NTRI_MOUSE
NC score	0.243777 (rank : 48)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	106	Target Neighborhood Hits	342	Shared Neighborhood Hits	96
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

NTRI_HUMAN
NC score	0.241254 (rank : 49)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	96
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

CDON_MOUSE
NC score	0.239898 (rank : 50)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	106	Target Neighborhood Hits	410	Shared Neighborhood Hits	95
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CNTN5_HUMAN
NC score	0.239853 (rank : 51)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	106	Target Neighborhood Hits	446	Shared Neighborhood Hits	98
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

VCAM1_MOUSE
NC score	0.239464 (rank : 52)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	106	Target Neighborhood Hits	320	Shared Neighborhood Hits	90
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

ROBO2_MOUSE
NC score	0.239347 (rank : 53)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	106	Target Neighborhood Hits	504	Shared Neighborhood Hits	98
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

FLT3_MOUSE
NC score	0.239114 (rank : 54)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	52
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

L1CAM_HUMAN
NC score	0.239003 (rank : 55)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	106	Target Neighborhood Hits	457	Shared Neighborhood Hits	98
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN4_MOUSE
NC score	0.237911 (rank : 56)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	106	Target Neighborhood Hits	445	Shared Neighborhood Hits	98
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

DCC_HUMAN
NC score	0.237330 (rank : 57)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	106	Target Neighborhood Hits	583	Shared Neighborhood Hits	98
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

CNTN6_MOUSE
NC score	0.237171 (rank : 58)	θ value	0.279714 (rank : 44)
Query Neighborhood Hits	106	Target Neighborhood Hits	429	Shared Neighborhood Hits	98
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTN2_MOUSE
NC score	0.236321 (rank : 59)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	97
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

SDK2_MOUSE
NC score	0.236228 (rank : 60)	θ value	0.00509761 (rank : 26)
Query Neighborhood Hits	106	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CNTN4_HUMAN
NC score	0.236209 (rank : 61)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	106	Target Neighborhood Hits	449	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

BOC_HUMAN
NC score	0.235781 (rank : 62)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	106	Target Neighborhood Hits	543	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

ROBO2_HUMAN
NC score	0.235756 (rank : 63)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	106	Target Neighborhood Hits	479	Shared Neighborhood Hits	96
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CNTN3_HUMAN
NC score	0.235748 (rank : 64)	θ value	0.163984 (rank : 39)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	98
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN2_HUMAN
NC score	0.235588 (rank : 65)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	106	Target Neighborhood Hits	440	Shared Neighborhood Hits	97
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN6_HUMAN
NC score	0.235025 (rank : 66)	θ value	0.0431538 (rank : 32)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

SDK2_HUMAN
NC score	0.234518 (rank : 67)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	106	Target Neighborhood Hits	495	Shared Neighborhood Hits	98
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

PUNC_HUMAN
NC score	0.234106 (rank : 68)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	106	Target Neighborhood Hits	449	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PUNC_MOUSE
NC score	0.234100 (rank : 69)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	106	Target Neighborhood Hits	501	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

BOC_MOUSE
NC score	0.233916 (rank : 70)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	106	Target Neighborhood Hits	433	Shared Neighborhood Hits	95
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

FLT3_HUMAN
NC score	0.233495 (rank : 71)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	44
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

CNTN1_HUMAN
NC score	0.232835 (rank : 72)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	106	Target Neighborhood Hits	431	Shared Neighborhood Hits	97
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
NC score	0.232696 (rank : 73)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	98
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

HMCN1_HUMAN
NC score	0.231982 (rank : 74)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

NEO1_MOUSE
NC score	0.230265 (rank : 75)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	106	Target Neighborhood Hits	523	Shared Neighborhood Hits	97
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

PGBM_HUMAN
NC score	0.229849 (rank : 76)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	106	Target Neighborhood Hits	1113	Shared Neighborhood Hits	98
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

DCC_MOUSE
NC score	0.229543 (rank : 77)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	106	Target Neighborhood Hits	896	Shared Neighborhood Hits	98
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NEO1_HUMAN
NC score	0.229471 (rank : 78)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	106	Target Neighborhood Hits	530	Shared Neighborhood Hits	96
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

SDK1_HUMAN
NC score	0.229350 (rank : 79)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	106	Target Neighborhood Hits	511	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

NEGR1_HUMAN
NC score	0.228225 (rank : 80)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	106	Target Neighborhood Hits	346	Shared Neighborhood Hits	96
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

SDK1_MOUSE
NC score	0.228215 (rank : 81)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	106	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

NFASC_MOUSE
NC score	0.226995 (rank : 82)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	106	Target Neighborhood Hits	475	Shared Neighborhood Hits	96
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

TMIGD_MOUSE
NC score	0.226095 (rank : 83)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	106	Target Neighborhood Hits	234	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

NEGR1_MOUSE
NC score	0.224378 (rank : 84)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	106	Target Neighborhood Hits	349	Shared Neighborhood Hits	96
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NFASC_HUMAN
NC score	0.223363 (rank : 85)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	106	Target Neighborhood Hits	497	Shared Neighborhood Hits	96
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

CD166_MOUSE
NC score	0.223052 (rank : 86)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	106	Target Neighborhood Hits	252	Shared Neighborhood Hits	77
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CHL1_MOUSE
NC score	0.223044 (rank : 87)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	106	Target Neighborhood Hits	402	Shared Neighborhood Hits	96
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

NRCAM_MOUSE
NC score	0.221159 (rank : 88)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	106	Target Neighborhood Hits	432	Shared Neighborhood Hits	96
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

MFA3L_HUMAN
NC score	0.219406 (rank : 89)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	106	Target Neighborhood Hits	230	Shared Neighborhood Hits	86
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

CNTN3_MOUSE
NC score	0.218978 (rank : 90)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	106	Target Neighborhood Hits	447	Shared Neighborhood Hits	97
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

TMIGD_HUMAN
NC score	0.216622 (rank : 91)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	106	Target Neighborhood Hits	240	Shared Neighborhood Hits	83
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

NRCAM_HUMAN
NC score	0.213631 (rank : 92)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	106	Target Neighborhood Hits	439	Shared Neighborhood Hits	95
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

CHL1_HUMAN
NC score	0.213147 (rank : 93)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	106	Target Neighborhood Hits	413	Shared Neighborhood Hits	94
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

PGBM_MOUSE
NC score	0.212532 (rank : 94)	θ value	0.0736092 (rank : 34)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	98
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

MAG_HUMAN
NC score	0.211814 (rank : 95)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	106	Target Neighborhood Hits	278	Shared Neighborhood Hits	90
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_MOUSE
NC score	0.211777 (rank : 96)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	89
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

FSTL4_HUMAN
NC score	0.211105 (rank : 97)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	106	Target Neighborhood Hits	344	Shared Neighborhood Hits	95
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

CD166_HUMAN
NC score	0.210631 (rank : 98)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	106	Target Neighborhood Hits	247	Shared Neighborhood Hits	76
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

NPTN_HUMAN
NC score	0.208283 (rank : 99)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	106	Target Neighborhood Hits	212	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

LU_HUMAN
NC score	0.207695 (rank : 100)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	106	Target Neighborhood Hits	283	Shared Neighborhood Hits	92
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

JAM2_HUMAN
NC score	0.207358 (rank : 101)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	106	Target Neighborhood Hits	304	Shared Neighborhood Hits	88
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

FSTL4_MOUSE
NC score	0.207162 (rank : 102)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	106	Target Neighborhood Hits	333	Shared Neighborhood Hits	93
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

RAGE_MOUSE
NC score	0.206212 (rank : 103)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	106	Target Neighborhood Hits	295	Shared Neighborhood Hits	83
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

ROBO4_MOUSE
NC score	0.205910 (rank : 104)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	106	Target Neighborhood Hits	358	Shared Neighborhood Hits	79
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

RAGE_HUMAN
NC score	0.204425 (rank : 105)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	106	Target Neighborhood Hits	269	Shared Neighborhood Hits	85
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

MUC18_MOUSE
NC score	0.203606 (rank : 106)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MUSK_MOUSE
NC score	0.202822 (rank : 107)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	106	Target Neighborhood Hits	1057	Shared Neighborhood Hits	93
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PTK7_HUMAN
NC score	0.202269 (rank : 108)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	96
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

MUSK_HUMAN
NC score	0.201556 (rank : 109)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	106	Target Neighborhood Hits	1074	Shared Neighborhood Hits	95
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

NPTN_MOUSE
NC score	0.200963 (rank : 110)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	106	Target Neighborhood Hits	216	Shared Neighborhood Hits	80
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

ROBO4_HUMAN
NC score	0.200612 (rank : 111)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	106	Target Neighborhood Hits	364	Shared Neighborhood Hits	82
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

MYOM1_MOUSE
NC score	0.199748 (rank : 112)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	106	Target Neighborhood Hits	415	Shared Neighborhood Hits	88
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

NPHN_HUMAN
NC score	0.198589 (rank : 113)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	106	Target Neighborhood Hits	362	Shared Neighborhood Hits	90
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

FGFR4_MOUSE
NC score	0.198496 (rank : 114)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	94
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

CD22_HUMAN
NC score	0.198363 (rank : 115)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	106	Target Neighborhood Hits	365	Shared Neighborhood Hits	83
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

BASI_MOUSE
NC score	0.198150 (rank : 116)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	106	Target Neighborhood Hits	238	Shared Neighborhood Hits	89
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

FSTL5_MOUSE
NC score	0.197534 (rank : 117)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	106	Target Neighborhood Hits	355	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

JAM1_HUMAN
NC score	0.197197 (rank : 118)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	106	Target Neighborhood Hits	294	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

FGFR3_MOUSE
NC score	0.197011 (rank : 119)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	106	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

NPHN_MOUSE
NC score	0.196599 (rank : 120)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	106	Target Neighborhood Hits	370	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

FGFR1_HUMAN
NC score	0.195749 (rank : 121)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	106	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
NC score	0.195624 (rank : 122)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	106	Target Neighborhood Hits	1068	Shared Neighborhood Hits	93
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR3_HUMAN
NC score	0.195245 (rank : 123)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	106	Target Neighborhood Hits	1042	Shared Neighborhood Hits	91
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR4_HUMAN
NC score	0.195014 (rank : 124)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	106	Target Neighborhood Hits	1037	Shared Neighborhood Hits	94
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

MALT1_HUMAN
NC score	0.195004 (rank : 125)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	106	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

FGFR2_HUMAN
NC score	0.194242 (rank : 126)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	106	Target Neighborhood Hits	1062	Shared Neighborhood Hits	91
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FSTL5_HUMAN
NC score	0.194002 (rank : 127)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	106	Target Neighborhood Hits	347	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

CEAM5_HUMAN
NC score	0.193962 (rank : 128)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	106	Target Neighborhood Hits	343	Shared Neighborhood Hits	90
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

MYPC1_HUMAN
NC score	0.193108 (rank : 129)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	106	Target Neighborhood Hits	303	Shared Neighborhood Hits	85
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYBPH_HUMAN
NC score	0.192993 (rank : 130)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	106	Target Neighborhood Hits	256	Shared Neighborhood Hits	87
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

LRIG1_HUMAN
NC score	0.192873 (rank : 131)	θ value	0.47712 (rank : 51)
Query Neighborhood Hits	106	Target Neighborhood Hits	654	Shared Neighborhood Hits	97
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MFA3L_MOUSE
NC score	0.192825 (rank : 132)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	106	Target Neighborhood Hits	214	Shared Neighborhood Hits	82
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

FGFR2_MOUSE
NC score	0.192697 (rank : 133)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	106	Target Neighborhood Hits	1062	Shared Neighborhood Hits	91
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

KIRR1_HUMAN
NC score	0.192165 (rank : 134)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	106	Target Neighborhood Hits	401	Shared Neighborhood Hits	86
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

MUC18_HUMAN
NC score	0.192139 (rank : 135)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	106	Target Neighborhood Hits	275	Shared Neighborhood Hits	81
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

TITIN_HUMAN
NC score	0.190734 (rank : 136)	θ value	0.00102713 (rank : 18)
Query Neighborhood Hits	106	Target Neighborhood Hits	2923	Shared Neighborhood Hits	100
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MYPC2_HUMAN
NC score	0.190435 (rank : 137)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	106	Target Neighborhood Hits	316	Shared Neighborhood Hits	89
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

JAM2_MOUSE
NC score	0.189958 (rank : 138)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

CEAM1_MOUSE
NC score	0.189836 (rank : 139)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	90
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

NRG2_HUMAN
NC score	0.189349 (rank : 140)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	106	Target Neighborhood Hits	419	Shared Neighborhood Hits	86
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

MYOM2_HUMAN
NC score	0.189019 (rank : 141)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	106	Target Neighborhood Hits	341	Shared Neighborhood Hits	85
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

BASI_HUMAN
NC score	0.188493 (rank : 142)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	106	Target Neighborhood Hits	211	Shared Neighborhood Hits	82
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

MYBPH_MOUSE
NC score	0.187558 (rank : 143)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	106	Target Neighborhood Hits	290	Shared Neighborhood Hits	85
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

ROR2_MOUSE
NC score	0.187289 (rank : 144)	θ value	0.0252991 (rank : 30)
Query Neighborhood Hits	106	Target Neighborhood Hits	1000	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

LRIG1_MOUSE
NC score	0.186031 (rank : 145)	θ value	1.06291 (rank : 59)
Query Neighborhood Hits	106	Target Neighborhood Hits	627	Shared Neighborhood Hits	97
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYPC2_MOUSE
NC score	0.185151 (rank : 146)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	106	Target Neighborhood Hits	297	Shared Neighborhood Hits	87
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

CD22_MOUSE
NC score	0.184949 (rank : 147)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	106	Target Neighborhood Hits	331	Shared Neighborhood Hits	87
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

GPA33_MOUSE
NC score	0.184756 (rank : 148)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	106	Target Neighborhood Hits	294	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

NRG2_MOUSE
NC score	0.184428 (rank : 149)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	106	Target Neighborhood Hits	392	Shared Neighborhood Hits	86
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

MYOM1_HUMAN
NC score	0.184274 (rank : 150)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	106	Target Neighborhood Hits	405	Shared Neighborhood Hits	87
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

KIRR1_MOUSE
NC score	0.184182 (rank : 151)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	106	Target Neighborhood Hits	403	Shared Neighborhood Hits	86
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

JAM1_MOUSE
NC score	0.184111 (rank : 152)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	106	Target Neighborhood Hits	287	Shared Neighborhood Hits	81
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

ROR2_HUMAN
NC score	0.183966 (rank : 153)	θ value	0.00869519 (rank : 28)
Query Neighborhood Hits	106	Target Neighborhood Hits	1014	Shared Neighborhood Hits	91
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

IGS4B_MOUSE
NC score	0.181304 (rank : 154)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	106	Target Neighborhood Hits	328	Shared Neighborhood Hits	85
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

LRIG2_HUMAN
NC score	0.181298 (rank : 155)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	106	Target Neighborhood Hits	595	Shared Neighborhood Hits	95
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

JAM3_MOUSE
NC score	0.181289 (rank : 156)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	106	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

FCRL5_HUMAN
NC score	0.181003 (rank : 157)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	106	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

LRIG2_MOUSE
NC score	0.179330 (rank : 158)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	106	Target Neighborhood Hits	586	Shared Neighborhood Hits	95
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

KIRR2_HUMAN
NC score	0.177753 (rank : 159)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	106	Target Neighborhood Hits	321	Shared Neighborhood Hits	88
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

CEAM1_HUMAN
NC score	0.175188 (rank : 160)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	106	Target Neighborhood Hits	348	Shared Neighborhood Hits	82
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

ROR1_HUMAN
NC score	0.174062 (rank : 161)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	106	Target Neighborhood Hits	1018	Shared Neighborhood Hits	93
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

MYPC3_HUMAN
NC score	0.173451 (rank : 162)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	106	Target Neighborhood Hits	318	Shared Neighborhood Hits	83
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

KIRR2_MOUSE
NC score	0.173273 (rank : 163)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

ICAM5_MOUSE
NC score	0.172322 (rank : 164)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	106	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

CI094_HUMAN
NC score	0.172001 (rank : 165)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	106	Target Neighborhood Hits	310	Shared Neighborhood Hits	83
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

ROR1_MOUSE
NC score	0.171942 (rank : 166)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	106	Target Neighborhood Hits	1025	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

NTRK2_HUMAN
NC score	0.171571 (rank : 167)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	106	Target Neighborhood Hits	1081	Shared Neighborhood Hits	95
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

MYPC3_MOUSE
NC score	0.171439 (rank : 168)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	106	Target Neighborhood Hits	310	Shared Neighborhood Hits	80
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NTRK2_MOUSE
NC score	0.170973 (rank : 169)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	106	Target Neighborhood Hits	1088	Shared Neighborhood Hits	95
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ICAM5_HUMAN
NC score	0.170318 (rank : 170)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	106	Target Neighborhood Hits	276	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

TYRO3_HUMAN
NC score	0.170274 (rank : 171)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	106	Target Neighborhood Hits	995	Shared Neighborhood Hits	87
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

KIRR3_MOUSE
NC score	0.169762 (rank : 172)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	106	Target Neighborhood Hits	292	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

JAM3_HUMAN
NC score	0.169594 (rank : 173)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	83
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

TYRO3_MOUSE
NC score	0.169395 (rank : 174)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	106	Target Neighborhood Hits	1007	Shared Neighborhood Hits	88
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

LRIG3_MOUSE
NC score	0.169070 (rank : 175)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	106	Target Neighborhood Hits	611	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

SIG10_HUMAN
NC score	0.168726 (rank : 176)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	106	Target Neighborhood Hits	363	Shared Neighborhood Hits	81
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

CEA20_HUMAN
NC score	0.168551 (rank : 177)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	69
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

KIRR3_HUMAN
NC score	0.167559 (rank : 178)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	106	Target Neighborhood Hits	302	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

IGS4B_HUMAN
NC score	0.166842 (rank : 179)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	106	Target Neighborhood Hits	305	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

FCRL2_HUMAN
NC score	0.166816 (rank : 180)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	74
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

VSIG4_HUMAN
NC score	0.166473 (rank : 181)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	106	Target Neighborhood Hits	236	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

SIG11_HUMAN
NC score	0.165019 (rank : 182)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	106	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

LRIG3_HUMAN
NC score	0.164046 (rank : 183)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	106	Target Neighborhood Hits	601	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

MERTK_HUMAN
NC score	0.163759 (rank : 184)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	86
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PTPRF_HUMAN
NC score	0.163282 (rank : 185)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	106	Target Neighborhood Hits	489	Shared Neighborhood Hits	97
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

NTRK3_HUMAN
NC score	0.163107 (rank : 186)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	106	Target Neighborhood Hits	1115	Shared Neighborhood Hits	90
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PTPRD_MOUSE
NC score	0.161785 (rank : 187)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	106	Target Neighborhood Hits	491	Shared Neighborhood Hits	95
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

MERTK_MOUSE
NC score	0.160816 (rank : 188)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	106	Target Neighborhood Hits	974	Shared Neighborhood Hits	82
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

VSIG2_HUMAN
NC score	0.159657 (rank : 189)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	106	Target Neighborhood Hits	321	Shared Neighborhood Hits	86
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

PTPRD_HUMAN
NC score	0.159412 (rank : 190)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	106	Target Neighborhood Hits	485	Shared Neighborhood Hits	94
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

VSIG2_MOUSE
NC score	0.158613 (rank : 191)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	106	Target Neighborhood Hits	316	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

PTPRS_HUMAN
NC score	0.158420 (rank : 192)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	95
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

UFO_MOUSE
NC score	0.157831 (rank : 193)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	83
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

RET_MOUSE
NC score	0.157799 (rank : 194)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	106	Target Neighborhood Hits	884	Shared Neighborhood Hits	29
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

SIGL5_MOUSE
NC score	0.157610 (rank : 195)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	106	Target Neighborhood Hits	271	Shared Neighborhood Hits	90
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

RET_HUMAN
NC score	0.156731 (rank : 196)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

UFO_HUMAN
NC score	0.156206 (rank : 197)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	106	Target Neighborhood Hits	981	Shared Neighborhood Hits	78
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

TIE1_MOUSE
NC score	0.153557 (rank : 198)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	106	Target Neighborhood Hits	1266	Shared Neighborhood Hits	77
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_HUMAN
NC score	0.153411 (rank : 199)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	106	Target Neighborhood Hits	1241	Shared Neighborhood Hits	73
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

IL1R2_HUMAN
NC score	0.152768 (rank : 200)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	106	Target Neighborhood Hits	153	Shared Neighborhood Hits	60
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

OBSCN_HUMAN
NC score	0.150431 (rank : 201)	θ value	0.00509761 (rank : 25)
Query Neighborhood Hits	106	Target Neighborhood Hits	1931	Shared Neighborhood Hits	97
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

KAZD1_MOUSE
NC score	0.149837 (rank : 202)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	106	Target Neighborhood Hits	281	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

NTRK1_HUMAN
NC score	0.149277 (rank : 203)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	106	Target Neighborhood Hits	1023	Shared Neighborhood Hits	70
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

TIE2_HUMAN
NC score	0.148529 (rank : 204)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	106	Target Neighborhood Hits	1192	Shared Neighborhood Hits	65
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.148440 (rank : 205)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	106	Target Neighborhood Hits	1204	Shared Neighborhood Hits	65
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

RYK_HUMAN
NC score	0.146681 (rank : 206)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	106	Target Neighborhood Hits	701	Shared Neighborhood Hits	24
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ROS_HUMAN
NC score	0.145623 (rank : 207)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	106	Target Neighborhood Hits	907	Shared Neighborhood Hits	60
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_MOUSE
NC score	0.145253 (rank : 208)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	24
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ATL3_HUMAN
NC score	0.145132 (rank : 209)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	106	Target Neighborhood Hits	414	Shared Neighborhood Hits	92
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

GPA33_HUMAN
NC score	0.143669 (rank : 210)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	106	Target Neighborhood Hits	273	Shared Neighborhood Hits	62
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

NRG1_HUMAN
NC score	0.142259 (rank : 211)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	106	Target Neighborhood Hits	285	Shared Neighborhood Hits	68
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

STYK1_MOUSE
NC score	0.141771 (rank : 212)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	106	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

LTK_MOUSE
NC score	0.141419 (rank : 213)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	106	Target Neighborhood Hits	770	Shared Neighborhood Hits	26
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

CEAM6_HUMAN
NC score	0.141045 (rank : 214)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	106	Target Neighborhood Hits	308	Shared Neighborhood Hits	88
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

INSRR_MOUSE
NC score	0.140781 (rank : 215)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	106	Target Neighborhood Hits	961	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IGF1R_MOUSE
NC score	0.139755 (rank : 216)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	106	Target Neighborhood Hits	973	Shared Neighborhood Hits	46
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LTK_HUMAN
NC score	0.139377 (rank : 217)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	106	Target Neighborhood Hits	774	Shared Neighborhood Hits	27
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

INSR_MOUSE
NC score	0.138765 (rank : 218)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	106	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSRR_HUMAN
NC score	0.138561 (rank : 219)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	106	Target Neighborhood Hits	950	Shared Neighborhood Hits	47
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
NC score	0.138376 (rank : 220)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	106	Target Neighborhood Hits	963	Shared Neighborhood Hits	42
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IGF1R_HUMAN
NC score	0.138313 (rank : 221)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	106	Target Neighborhood Hits	977	Shared Neighborhood Hits	46
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

STYK1_HUMAN
NC score	0.137670 (rank : 222)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	106	Target Neighborhood Hits	786	Shared Neighborhood Hits	26
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ALK_MOUSE
NC score	0.137395 (rank : 223)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	106	Target Neighborhood Hits	811	Shared Neighborhood Hits	27
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

SPEG_MOUSE
NC score	0.137257 (rank : 224)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	106	Target Neighborhood Hits	1959	Shared Neighborhood Hits	98
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ALK_HUMAN
NC score	0.136624 (rank : 225)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	106	Target Neighborhood Hits	795	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

DDR1_MOUSE
NC score	0.136528 (rank : 226)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	27
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

SPEG_HUMAN
NC score	0.135592 (rank : 227)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	106	Target Neighborhood Hits	1762	Shared Neighborhood Hits	98
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SIGL8_HUMAN
NC score	0.135038 (rank : 228)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	106	Target Neighborhood Hits	252	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

MYLK_HUMAN
NC score	0.132905 (rank : 229)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	106	Target Neighborhood Hits	1328	Shared Neighborhood Hits	97
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
NC score	0.132815 (rank : 230)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	106	Target Neighborhood Hits	1489	Shared Neighborhood Hits	97
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DDR1_HUMAN
NC score	0.132223 (rank : 231)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	106	Target Neighborhood Hits	819	Shared Neighborhood Hits	27
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

KAZD1_HUMAN
NC score	0.130364 (rank : 232)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	106	Target Neighborhood Hits	248	Shared Neighborhood Hits	70
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

IBP7_MOUSE
NC score	0.130254 (rank : 233)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	106	Target Neighborhood Hits	230	Shared Neighborhood Hits	70
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IBP7_HUMAN
NC score	0.129891 (rank : 234)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	106	Target Neighborhood Hits	220	Shared Neighborhood Hits	70
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

RON_MOUSE
NC score	0.129324 (rank : 235)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	25
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

MET_MOUSE
NC score	0.129290 (rank : 236)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	106	Target Neighborhood Hits	844	Shared Neighborhood Hits	25
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_HUMAN
NC score	0.128920 (rank : 237)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	25
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RON_HUMAN
NC score	0.127723 (rank : 238)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	25
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DDR2_MOUSE
NC score	0.127192 (rank : 239)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	106	Target Neighborhood Hits	813	Shared Neighborhood Hits	26
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

LRRN1_HUMAN
NC score	0.126328 (rank : 240)	θ value	0.125558 (rank : 36)
Query Neighborhood Hits	106	Target Neighborhood Hits	518	Shared Neighborhood Hits	90
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

DDR2_HUMAN
NC score	0.126158 (rank : 241)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	26
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

TNK1_HUMAN
NC score	0.125861 (rank : 242)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	26
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

ERBB3_MOUSE
NC score	0.125564 (rank : 243)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	106	Target Neighborhood Hits	898	Shared Neighborhood Hits	26
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB3_HUMAN
NC score	0.125342 (rank : 244)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	106	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

TNK1_MOUSE
NC score	0.125184 (rank : 245)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	106	Target Neighborhood Hits	806	Shared Neighborhood Hits	27
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

PSG8_HUMAN
NC score	0.124815 (rank : 246)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	106	Target Neighborhood Hits	239	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG4_HUMAN
NC score	0.124336 (rank : 247)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	106	Target Neighborhood Hits	243	Shared Neighborhood Hits	74
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

ACK1_MOUSE
NC score	0.123965 (rank : 248)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	106	Target Neighborhood Hits	1080	Shared Neighborhood Hits	27
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FAK2_HUMAN
NC score	0.123940 (rank : 249)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHA6_HUMAN
NC score	0.123655 (rank : 250)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	106	Target Neighborhood Hits	959	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

SIGL5_HUMAN
NC score	0.123243 (rank : 251)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	106	Target Neighborhood Hits	246	Shared Neighborhood Hits	70
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

ACK1_HUMAN
NC score	0.123208 (rank : 252)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	106	Target Neighborhood Hits	1140	Shared Neighborhood Hits	27
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

FAK2_MOUSE
NC score	0.122664 (rank : 253)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

SIG12_HUMAN
NC score	0.122413 (rank : 254)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	106	Target Neighborhood Hits	245	Shared Neighborhood Hits	79
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

PSG3_HUMAN
NC score	0.122368 (rank : 255)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	106	Target Neighborhood Hits	242	Shared Neighborhood Hits	76
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

ERBB2_MOUSE
NC score	0.122250 (rank : 256)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	106	Target Neighborhood Hits	918	Shared Neighborhood Hits	27
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB2_HUMAN
NC score	0.122119 (rank : 257)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	27
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHA6_MOUSE
NC score	0.121613 (rank : 258)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	106	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

AATK_MOUSE
NC score	0.121591 (rank : 259)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	106	Target Neighborhood Hits	942	Shared Neighborhood Hits	27
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

EGFR_MOUSE
NC score	0.120969 (rank : 260)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	106	Target Neighborhood Hits	927	Shared Neighborhood Hits	28
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EGFR_HUMAN
NC score	0.120870 (rank : 261)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	106	Target Neighborhood Hits	939	Shared Neighborhood Hits	27
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

LRRN1_MOUSE
NC score	0.120674 (rank : 262)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	106	Target Neighborhood Hits	508	Shared Neighborhood Hits	89
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

MATK_HUMAN
NC score	0.120071 (rank : 263)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	106	Target Neighborhood Hits	954	Shared Neighborhood Hits	26
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PECA1_HUMAN
NC score	0.119810 (rank : 264)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	106	Target Neighborhood Hits	178	Shared Neighborhood Hits	60
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

EPHB3_MOUSE
NC score	0.119779 (rank : 265)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	106	Target Neighborhood Hits	996	Shared Neighborhood Hits	60
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MATK_MOUSE
NC score	0.119341 (rank : 266)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	106	Target Neighborhood Hits	952	Shared Neighborhood Hits	26
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FAK1_HUMAN
NC score	0.119335 (rank : 267)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

EPHB3_HUMAN
NC score	0.119291 (rank : 268)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	106	Target Neighborhood Hits	996	Shared Neighborhood Hits	61
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA5_MOUSE
NC score	0.119259 (rank : 269)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	106	Target Neighborhood Hits	950	Shared Neighborhood Hits	57
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

AATK_HUMAN
NC score	0.119177 (rank : 270)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	106	Target Neighborhood Hits	1243	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

FAK1_MOUSE
NC score	0.119159 (rank : 271)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

EPHA2_MOUSE
NC score	0.119036 (rank : 272)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	106	Target Neighborhood Hits	1020	Shared Neighborhood Hits	59
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA7_HUMAN
NC score	0.118605 (rank : 273)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	106	Target Neighborhood Hits	1053	Shared Neighborhood Hits	59
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA2_HUMAN
NC score	0.118414 (rank : 274)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	106	Target Neighborhood Hits	1021	Shared Neighborhood Hits	58
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ESAM_HUMAN
NC score	0.118412 (rank : 275)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	106	Target Neighborhood Hits	251	Shared Neighborhood Hits	67
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

EPHA8_MOUSE
NC score	0.118246 (rank : 276)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	106	Target Neighborhood Hits	969	Shared Neighborhood Hits	63
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB4_MOUSE
NC score	0.118223 (rank : 277)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	106	Target Neighborhood Hits	1013	Shared Neighborhood Hits	63
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA7_MOUSE
NC score	0.118217 (rank : 278)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	106	Target Neighborhood Hits	1025	Shared Neighborhood Hits	58
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

CEAM8_HUMAN
NC score	0.118089 (rank : 279)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	106	Target Neighborhood Hits	264	Shared Neighborhood Hits	79
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

EPHB4_HUMAN
NC score	0.118038 (rank : 280)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	106	Target Neighborhood Hits	1056	Shared Neighborhood Hits	61
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA8_HUMAN
NC score	0.118026 (rank : 281)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	106	Target Neighborhood Hits	956	Shared Neighborhood Hits	62
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ERBB4_HUMAN
NC score	0.117872 (rank : 282)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	106	Target Neighborhood Hits	910	Shared Neighborhood Hits	28
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EPHA3_HUMAN
NC score	0.117765 (rank : 283)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	106	Target Neighborhood Hits	1005	Shared Neighborhood Hits	64
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
NC score	0.117744 (rank : 284)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	63
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

PSG1_HUMAN
NC score	0.117443 (rank : 285)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	106	Target Neighborhood Hits	232	Shared Neighborhood Hits	75
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

EPHA4_MOUSE
NC score	0.117379 (rank : 286)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	106	Target Neighborhood Hits	982	Shared Neighborhood Hits	58
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.116920 (rank : 287)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	106	Target Neighborhood Hits	975	Shared Neighborhood Hits	58
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

SRMS_HUMAN
NC score	0.116916 (rank : 288)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	106	Target Neighborhood Hits	946	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

EPHA1_MOUSE
NC score	0.116774 (rank : 289)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	106	Target Neighborhood Hits	958	Shared Neighborhood Hits	52
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EMB_MOUSE
NC score	0.116607 (rank : 290)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	106	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

FER_HUMAN
NC score	0.116196 (rank : 291)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	106	Target Neighborhood Hits	1278	Shared Neighborhood Hits	26
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ZAP70_MOUSE
NC score	0.116144 (rank : 292)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	106	Target Neighborhood Hits	905	Shared Neighborhood Hits	26
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EPHA1_HUMAN
NC score	0.115906 (rank : 293)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	106	Target Neighborhood Hits	997	Shared Neighborhood Hits	50
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KSYK_HUMAN
NC score	0.115896 (rank : 294)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	106	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SRMS_MOUSE
NC score	0.115857 (rank : 295)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	106	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

EPHA5_HUMAN
NC score	0.115796 (rank : 296)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PTK6_MOUSE
NC score	0.115788 (rank : 297)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	26
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

KSYK_MOUSE
NC score	0.115759 (rank : 298)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	106	Target Neighborhood Hits	944	Shared Neighborhood Hits	26
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FES_MOUSE
NC score	0.115701 (rank : 299)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.115543 (rank : 300)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	106	Target Neighborhood Hits	978	Shared Neighborhood Hits	26
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

EPHB1_HUMAN
NC score	0.115395 (rank : 301)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	106	Target Neighborhood Hits	988	Shared Neighborhood Hits	56
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB6_MOUSE
NC score	0.114906 (rank : 302)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	106	Target Neighborhood Hits	906	Shared Neighborhood Hits	58
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHB2_MOUSE
NC score	0.114617 (rank : 303)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	106	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.114572 (rank : 304)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	106	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

PSG2_HUMAN
NC score	0.114364 (rank : 305)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	106	Target Neighborhood Hits	229	Shared Neighborhood Hits	78
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

JAK3_HUMAN
NC score	0.114145 (rank : 306)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	106	Target Neighborhood Hits	827	Shared Neighborhood Hits	26
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

PSG7_HUMAN
NC score	0.113860 (rank : 307)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	106	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

EPHB6_HUMAN
NC score	0.113694 (rank : 308)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	106	Target Neighborhood Hits	912	Shared Neighborhood Hits	63
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

CSK_HUMAN
NC score	0.113527 (rank : 309)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

HCK_MOUSE
NC score	0.113167 (rank : 310)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	106	Target Neighborhood Hits	1029	Shared Neighborhood Hits	26
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.112784 (rank : 311)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	106	Target Neighborhood Hits	1035	Shared Neighborhood Hits	26
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BMX_MOUSE
NC score	0.112661 (rank : 312)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	106	Target Neighborhood Hits	912	Shared Neighborhood Hits	26
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

LRFN2_MOUSE
NC score	0.112589 (rank : 313)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	86
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PTK6_HUMAN
NC score	0.112542 (rank : 314)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	106	Target Neighborhood Hits	1020	Shared Neighborhood Hits	26
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

EPHAA_HUMAN
NC score	0.112126 (rank : 315)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	106	Target Neighborhood Hits	960	Shared Neighborhood Hits	52
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ZAP70_HUMAN
NC score	0.112086 (rank : 316)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	106	Target Neighborhood Hits	893	Shared Neighborhood Hits	26
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BMX_HUMAN
NC score	0.112028 (rank : 317)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	106	Target Neighborhood Hits	942	Shared Neighborhood Hits	26
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BLK_MOUSE
NC score	0.111493 (rank : 318)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	106	Target Neighborhood Hits	992	Shared Neighborhood Hits	26
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_HUMAN
NC score	0.111435 (rank : 319)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	106	Target Neighborhood Hits	994	Shared Neighborhood Hits	26
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LRFN2_HUMAN
NC score	0.111394 (rank : 320)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	106	Target Neighborhood Hits	450	Shared Neighborhood Hits	84
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

CXAR_HUMAN
NC score	0.111133 (rank : 321)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	106	Target Neighborhood Hits	245	Shared Neighborhood Hits	57
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

PSG11_HUMAN
NC score	0.111039 (rank : 322)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	106	Target Neighborhood Hits	223	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

CILP2_HUMAN
NC score	0.111001 (rank : 323)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	106	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CSK_MOUSE
NC score	0.110928 (rank : 324)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ABL2_HUMAN
NC score	0.110890 (rank : 325)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	106	Target Neighborhood Hits	1045	Shared Neighborhood Hits	26
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

PSG5_HUMAN
NC score	0.110632 (rank : 326)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	106	Target Neighborhood Hits	231	Shared Neighborhood Hits	73
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

SIGL6_HUMAN
NC score	0.110222 (rank : 327)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	106	Target Neighborhood Hits	233	Shared Neighborhood Hits	76
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

ITK_MOUSE
NC score	0.110199 (rank : 328)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	106	Target Neighborhood Hits	985	Shared Neighborhood Hits	26
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LCK_HUMAN
NC score	0.110083 (rank : 329)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	106	Target Neighborhood Hits	987	Shared Neighborhood Hits	26
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LRRN5_HUMAN
NC score	0.109961 (rank : 330)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	106	Target Neighborhood Hits	493	Shared Neighborhood Hits	86
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

TXK_MOUSE
NC score	0.109817 (rank : 331)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

JAK1_MOUSE
NC score	0.109783 (rank : 332)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ABL1_HUMAN
NC score	0.109767 (rank : 333)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	106	Target Neighborhood Hits	1220	Shared Neighborhood Hits	27
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.109400 (rank : 334)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	106	Target Neighborhood Hits	1178	Shared Neighborhood Hits	28
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TXK_HUMAN
NC score	0.109261 (rank : 335)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	106	Target Neighborhood Hits	971	Shared Neighborhood Hits	26
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ITK_HUMAN
NC score	0.109146 (rank : 336)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	106	Target Neighborhood Hits	1016	Shared Neighborhood Hits	26
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LCK_MOUSE
NC score	0.108907 (rank : 337)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	106	Target Neighborhood Hits	981	Shared Neighborhood Hits	26
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

PSG6_HUMAN
NC score	0.108827 (rank : 338)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	106	Target Neighborhood Hits	231	Shared Neighborhood Hits	75
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

JAK1_HUMAN
NC score	0.108722 (rank : 339)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

LYN_MOUSE
NC score	0.108565 (rank : 340)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	106	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.108410 (rank : 341)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	106	Target Neighborhood Hits	1022	Shared Neighborhood Hits	26
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FRK_HUMAN
NC score	0.108389 (rank : 342)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	106	Target Neighborhood Hits	1058	Shared Neighborhood Hits	26
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

JAK3_MOUSE
NC score	0.107968 (rank : 343)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

SRC_MOUSE
NC score	0.107525 (rank : 344)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	106	Target Neighborhood Hits	1033	Shared Neighborhood Hits	26
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FGR_MOUSE
NC score	0.107313 (rank : 345)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	106	Target Neighborhood Hits	1069	Shared Neighborhood Hits	26
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BTK_HUMAN
NC score	0.107282 (rank : 346)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	106	Target Neighborhood Hits	1026	Shared Neighborhood Hits	26
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.107246 (rank : 347)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	106	Target Neighborhood Hits	1017	Shared Neighborhood Hits	26
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PSG10_HUMAN
NC score	0.107142 (rank : 348)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	106	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

TEC_HUMAN
NC score	0.106901 (rank : 349)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	106	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CILP1_MOUSE
NC score	0.106883 (rank : 350)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	106	Target Neighborhood Hits	282	Shared Neighborhood Hits	73
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

SRC_HUMAN
NC score	0.106670 (rank : 351)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	106	Target Neighborhood Hits	1058	Shared Neighborhood Hits	26
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_MOUSE
NC score	0.106493 (rank : 352)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	106	Target Neighborhood Hits	1052	Shared Neighborhood Hits	26
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.106390 (rank : 353)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	106	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SIG12_MOUSE
NC score	0.106061 (rank : 354)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

FYN_MOUSE
NC score	0.106003 (rank : 355)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	106	Target Neighborhood Hits	1073	Shared Neighborhood Hits	26
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

JAK2_HUMAN
NC score	0.106001 (rank : 356)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

IL1R2_MOUSE
NC score	0.105921 (rank : 357)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	106	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

JAK2_MOUSE
NC score	0.105921 (rank : 358)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	106	Target Neighborhood Hits	839	Shared Neighborhood Hits	26
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

FGR_HUMAN
NC score	0.105696 (rank : 359)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	106	Target Neighborhood Hits	1067	Shared Neighborhood Hits	26
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TYK2_MOUSE
NC score	0.105661 (rank : 360)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	106	Target Neighborhood Hits	850	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TEC_MOUSE
NC score	0.105603 (rank : 361)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	106	Target Neighborhood Hits	1006	Shared Neighborhood Hits	26
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RIPK5_HUMAN
NC score	0.105109 (rank : 362)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

FYN_HUMAN
NC score	0.104937 (rank : 363)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	106	Target Neighborhood Hits	1078	Shared Neighborhood Hits	26
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

RIPK5_MOUSE
NC score	0.104633 (rank : 364)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

PSG9_HUMAN
NC score	0.104571 (rank : 365)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	106	Target Neighborhood Hits	221	Shared Neighborhood Hits	69
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

LRFN5_MOUSE
NC score	0.103837 (rank : 366)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	106	Target Neighborhood Hits	472	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

CD80_MOUSE
NC score	0.103760 (rank : 367)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	106	Target Neighborhood Hits	136	Shared Neighborhood Hits	35
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

TYK2_HUMAN
NC score	0.103597 (rank : 368)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	106	Target Neighborhood Hits	841	Shared Neighborhood Hits	26
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

IRPL2_HUMAN
NC score	0.103563 (rank : 369)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	106	Target Neighborhood Hits	194	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

CILP1_HUMAN
NC score	0.103552 (rank : 370)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	106	Target Neighborhood Hits	266	Shared Neighborhood Hits	69
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PVRL3_HUMAN
NC score	0.102396 (rank : 371)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	106	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

LRRN3_HUMAN
NC score	0.102233 (rank : 372)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	106	Target Neighborhood Hits	461	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

IRPL2_MOUSE
NC score	0.101827 (rank : 373)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

FNDC3_HUMAN
NC score	0.101238 (rank : 374)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	106	Target Neighborhood Hits	196	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

LRFN5_HUMAN
NC score	0.100986 (rank : 375)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	106	Target Neighborhood Hits	464	Shared Neighborhood Hits	88
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PVRL3_MOUSE
NC score	0.100852 (rank : 376)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	106	Target Neighborhood Hits	212	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PIGR_MOUSE
NC score	0.100794 (rank : 377)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	106	Target Neighborhood Hits	214	Shared Neighborhood Hits	53
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

FNDC3_MOUSE
NC score	0.100532 (rank : 378)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	106	Target Neighborhood Hits	207	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

LRFN4_MOUSE
NC score	0.099002 (rank : 379)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	106	Target Neighborhood Hits	442	Shared Neighborhood Hits	84
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN4_HUMAN
NC score	0.098778 (rank : 380)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	106	Target Neighborhood Hits	462	Shared Neighborhood Hits	84
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

M3KL4_HUMAN
NC score	0.097652 (rank : 381)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	106	Target Neighborhood Hits	1087	Shared Neighborhood Hits	26
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CXAR_MOUSE
NC score	0.097646 (rank : 382)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	106	Target Neighborhood Hits	250	Shared Neighborhood Hits	59
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

LRRN3_MOUSE
NC score	0.097604 (rank : 383)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

GUC2C_HUMAN
NC score	0.097349 (rank : 384)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	106	Target Neighborhood Hits	624	Shared Neighborhood Hits	23
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

LRFN3_MOUSE
NC score	0.097263 (rank : 385)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MLTK_MOUSE
NC score	0.095603 (rank : 386)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

IRPL1_MOUSE
NC score	0.095587 (rank : 387)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	106	Target Neighborhood Hits	186	Shared Neighborhood Hits	62
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

LRC21_MOUSE
NC score	0.095439 (rank : 388)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	106	Target Neighborhood Hits	462	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRC21_HUMAN
NC score	0.095174 (rank : 389)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	106	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

IRPL1_HUMAN
NC score	0.095071 (rank : 390)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	106	Target Neighborhood Hits	196	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

MLTK_HUMAN
NC score	0.094952 (rank : 391)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

M3K11_HUMAN
NC score	0.094539 (rank : 392)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	106	Target Neighborhood Hits	1136	Shared Neighborhood Hits	27
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
NC score	0.092870 (rank : 393)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	106	Target Neighborhood Hits	1123	Shared Neighborhood Hits	26
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.092128 (rank : 394)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	106	Target Neighborhood Hits	1071	Shared Neighborhood Hits	27
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ILRL2_MOUSE
NC score	0.091647 (rank : 395)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	106	Target Neighborhood Hits	158	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

M3K12_HUMAN
NC score	0.091424 (rank : 396)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	106	Target Neighborhood Hits	940	Shared Neighborhood Hits	26
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.091412 (rank : 397)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	106	Target Neighborhood Hits	957	Shared Neighborhood Hits	26
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PDL1_HUMAN
NC score	0.091213 (rank : 398)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

ESAM_MOUSE
NC score	0.091180 (rank : 399)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	106	Target Neighborhood Hits	222	Shared Neighborhood Hits	63
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

GUC2F_HUMAN
NC score	0.090773 (rank : 400)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	106	Target Neighborhood Hits	740	Shared Neighborhood Hits	25
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

LRFN3_HUMAN
NC score	0.089326 (rank : 401)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	106	Target Neighborhood Hits	444	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

UNC5D_MOUSE
NC score	0.089151 (rank : 402)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	106	Target Neighborhood Hits	268	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

RIPK1_MOUSE
NC score	0.088620 (rank : 403)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TOPK_MOUSE
NC score	0.087806 (rank : 404)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	106	Target Neighborhood Hits	618	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

LRC24_MOUSE
NC score	0.087559 (rank : 405)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	106	Target Neighborhood Hits	387	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

TOPK_HUMAN
NC score	0.087548 (rank : 406)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	106	Target Neighborhood Hits	605	Shared Neighborhood Hits	22
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

UNC5D_HUMAN
NC score	0.087270 (rank : 407)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	106	Target Neighborhood Hits	267	Shared Neighborhood Hits	73
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

M3K13_HUMAN
NC score	0.086814 (rank : 408)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MOS_MOUSE
NC score	0.086776 (rank : 409)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

M3K7_HUMAN
NC score	0.085515 (rank : 410)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

RIPK1_HUMAN
NC score	0.085477 (rank : 411)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	106	Target Neighborhood Hits	891	Shared Neighborhood Hits	26
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

LRC24_HUMAN
NC score	0.085263 (rank : 412)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	106	Target Neighborhood Hits	404	Shared Neighborhood Hits	77
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

M3K7_MOUSE
NC score	0.084966 (rank : 413)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

FCERA_HUMAN
NC score	0.084763 (rank : 414)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	106	Target Neighborhood Hits	150	Shared Neighborhood Hits	51
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

PDL2_MOUSE
NC score	0.084677 (rank : 415)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	106	Target Neighborhood Hits	116	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

RAF1_MOUSE
NC score	0.084586 (rank : 416)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MOS_HUMAN
NC score	0.084393 (rank : 417)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ARAF_MOUSE
NC score	0.084226 (rank : 418)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

SIGL7_HUMAN
NC score	0.084193 (rank : 419)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	106	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

ARAF_HUMAN
NC score	0.084158 (rank : 420)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	106	Target Neighborhood Hits	924	Shared Neighborhood Hits	26
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RAF1_HUMAN
NC score	0.083969 (rank : 421)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CD276_HUMAN
NC score	0.083630 (rank : 422)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	106	Target Neighborhood Hits	261	Shared Neighborhood Hits	51
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

E2AK3_MOUSE
NC score	0.083525 (rank : 423)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK3_HUMAN
NC score	0.082827 (rank : 424)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	106	Target Neighborhood Hits	859	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

CD80_HUMAN
NC score	0.082676 (rank : 425)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	106	Target Neighborhood Hits	129	Shared Neighborhood Hits	43
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

PIGR_HUMAN
NC score	0.081960 (rank : 426)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	106	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PECA1_MOUSE
NC score	0.081897 (rank : 427)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	106	Target Neighborhood Hits	126	Shared Neighborhood Hits	40
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

BRAF1_HUMAN
NC score	0.081797 (rank : 428)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	106	Target Neighborhood Hits	883	Shared Neighborhood Hits	26
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

TESK2_HUMAN
NC score	0.081737 (rank : 429)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LRRK1_HUMAN
NC score	0.080956 (rank : 430)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	106	Target Neighborhood Hits	1237	Shared Neighborhood Hits	33
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

JAML1_MOUSE
NC score	0.079745 (rank : 431)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	106	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

DUET_HUMAN
NC score	0.079522 (rank : 432)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	106	Target Neighborhood Hits	1220	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

LIMK1_MOUSE
NC score	0.079392 (rank : 433)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	106	Target Neighborhood Hits	1008	Shared Neighborhood Hits	27
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

KSR1_HUMAN
NC score	0.078981 (rank : 434)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

LRRK1_MOUSE
NC score	0.078791 (rank : 435)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	106	Target Neighborhood Hits	1267	Shared Neighborhood Hits	33
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PDL1_MOUSE
NC score	0.078572 (rank : 436)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	106	Target Neighborhood Hits	168	Shared Neighborhood Hits	52
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

ILK_MOUSE
NC score	0.078406 (rank : 437)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

RIPK3_HUMAN
NC score	0.078316 (rank : 438)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

LIMK1_HUMAN
NC score	0.078121 (rank : 439)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	106	Target Neighborhood Hits	1005	Shared Neighborhood Hits	26
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

PVRL2_HUMAN
NC score	0.078057 (rank : 440)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	106	Target Neighborhood Hits	185	Shared Neighborhood Hits	46
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVRL2_MOUSE
NC score	0.077757 (rank : 441)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	106	Target Neighborhood Hits	242	Shared Neighborhood Hits	44
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

IL1R1_HUMAN
NC score	0.077682 (rank : 442)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	106	Target Neighborhood Hits	140	Shared Neighborhood Hits	53
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

E2AK2_HUMAN
NC score	0.077630 (rank : 443)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	106	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

ANPRA_HUMAN
NC score	0.077374 (rank : 444)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	106	Target Neighborhood Hits	612	Shared Neighborhood Hits	22
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ILK1_HUMAN
NC score	0.077207 (rank : 445)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

TESK2_MOUSE
NC score	0.077059 (rank : 446)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

KSR1_MOUSE
NC score	0.077058 (rank : 447)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	106	Target Neighborhood Hits	870	Shared Neighborhood Hits	28
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

SCYL2_MOUSE
NC score	0.076527 (rank : 448)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	106	Target Neighborhood Hits	603	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

IRAK4_HUMAN
NC score	0.076505 (rank : 449)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	106	Target Neighborhood Hits	816	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

SCYL2_HUMAN
NC score	0.076294 (rank : 450)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	106	Target Neighborhood Hits	632	Shared Neighborhood Hits	24
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CD79A_HUMAN
NC score	0.076171 (rank : 451)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	106	Target Neighborhood Hits	102	Shared Neighborhood Hits	37
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

NGL1_MOUSE
NC score	0.076092 (rank : 452)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	106	Target Neighborhood Hits	512	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

CEAM7_HUMAN
NC score	0.075981 (rank : 453)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	106	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

NGL1_HUMAN
NC score	0.075825 (rank : 454)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	106	Target Neighborhood Hits	511	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

TNI3K_MOUSE
NC score	0.075467 (rank : 455)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	106	Target Neighborhood Hits	1079	Shared Neighborhood Hits	28
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

MLKL_HUMAN
NC score	0.075316 (rank : 456)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MP2K5_MOUSE
NC score	0.074995 (rank : 457)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

E2AK1_HUMAN
NC score	0.074885 (rank : 458)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

LRC4B_MOUSE
NC score	0.074338 (rank : 459)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	106	Target Neighborhood Hits	484	Shared Neighborhood Hits	87
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

EMB_HUMAN
NC score	0.074097 (rank : 460)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	106	Target Neighborhood Hits	54	Shared Neighborhood Hits	24
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

TNI3K_HUMAN
NC score	0.073528 (rank : 461)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	106	Target Neighborhood Hits	1084	Shared Neighborhood Hits	27
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

LRC4B_HUMAN
NC score	0.073515 (rank : 462)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	106	Target Neighborhood Hits	479	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

ILK2_HUMAN
NC score	0.073237 (rank : 463)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	106	Target Neighborhood Hits	848	Shared Neighborhood Hits	26
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

MLKL_MOUSE
NC score	0.072890 (rank : 464)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	106	Target Neighborhood Hits	707	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

PVRL1_MOUSE
NC score	0.072764 (rank : 465)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	106	Target Neighborhood Hits	201	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

IL1R1_MOUSE
NC score	0.072668 (rank : 466)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	106	Target Neighborhood Hits	142	Shared Neighborhood Hits	55
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

ANPRA_MOUSE
NC score	0.072651 (rank : 467)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	22
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

IRAK4_MOUSE
NC score	0.072486 (rank : 468)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	106	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

E2AK1_MOUSE
NC score	0.072432 (rank : 469)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CD4_HUMAN
NC score	0.072421 (rank : 470)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	106	Target Neighborhood Hits	122	Shared Neighborhood Hits	32
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

TESK1_HUMAN
NC score	0.071902 (rank : 471)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

PVR_HUMAN
NC score	0.071874 (rank : 472)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	106	Target Neighborhood Hits	195	Shared Neighborhood Hits	46
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

MOX2R_MOUSE
NC score	0.071093 (rank : 473)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	106	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

GUC2E_MOUSE
NC score	0.070897 (rank : 474)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	106	Target Neighborhood Hits	692	Shared Neighborhood Hits	25
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

TRIO_HUMAN
NC score	0.070675 (rank : 475)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	106	Target Neighborhood Hits	1580	Shared Neighborhood Hits	93
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TEX14_MOUSE
NC score	0.070222 (rank : 476)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	106	Target Neighborhood Hits	1333	Shared Neighborhood Hits	25
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TESK1_MOUSE
NC score	0.070127 (rank : 477)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	106	Target Neighborhood Hits	862	Shared Neighborhood Hits	27
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

PVRL1_HUMAN
NC score	0.069857 (rank : 478)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	106	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

ANPRB_HUMAN
NC score	0.069576 (rank : 479)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	106	Target Neighborhood Hits	646	Shared Neighborhood Hits	21
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2D_HUMAN
NC score	0.069346 (rank : 480)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	26
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

MP2K5_HUMAN
NC score	0.068723 (rank : 481)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK7_HUMAN
NC score	0.068511 (rank : 482)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	106	Target Neighborhood Hits	846	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

TTK_MOUSE
NC score	0.068391 (rank : 483)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	106	Target Neighborhood Hits	803	Shared Neighborhood Hits	26
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TTK_HUMAN
NC score	0.068133 (rank : 484)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	106	Target Neighborhood Hits	816	Shared Neighborhood Hits	26
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

KSR2_HUMAN
NC score	0.068075 (rank : 485)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	106	Target Neighborhood Hits	920	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

NEK7_MOUSE
NC score	0.068068 (rank : 486)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	106	Target Neighborhood Hits	847	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

LIMK2_HUMAN
NC score	0.067904 (rank : 487)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	106	Target Neighborhood Hits	986	Shared Neighborhood Hits	26
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
NC score	0.067690 (rank : 488)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	106	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ANPRB_MOUSE
NC score	0.067674 (rank : 489)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	106	Target Neighborhood Hits	607	Shared Neighborhood Hits	21
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

FINC_MOUSE
NC score	0.067611 (rank : 490)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	106	Target Neighborhood Hits	309	Shared Neighborhood Hits	41
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

ILRL1_HUMAN
NC score	0.067532 (rank : 491)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	106	Target Neighborhood Hits	167	Shared Neighborhood Hits	49
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

MFAP3_HUMAN
NC score	0.066980 (rank : 492)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	106	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

ANKK1_MOUSE
NC score	0.066700 (rank : 493)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	106	Target Neighborhood Hits	1072	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

IGSF2_HUMAN
NC score	0.066622 (rank : 494)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	106	Target Neighborhood Hits	208	Shared Neighborhood Hits	39
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

UHMK1_MOUSE
NC score	0.066604 (rank : 495)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	106	Target Neighborhood Hits	809	Shared Neighborhood Hits	24
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_HUMAN
NC score	0.066377 (rank : 496)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

LRRK2_HUMAN
NC score	0.066375 (rank : 497)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	106	Target Neighborhood Hits	1382	Shared Neighborhood Hits	31
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

MK01_MOUSE
NC score	0.066312 (rank : 498)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.066290 (rank : 499)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

LRRC4_HUMAN
NC score	0.066083 (rank : 500)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	106	Target Neighborhood Hits	444	Shared Neighborhood Hits	76
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

LRRK2_MOUSE
NC score	0.065966 (rank : 501)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	106	Target Neighborhood Hits	1359	Shared Neighborhood Hits	30
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

CDK5_MOUSE
NC score	0.065924 (rank : 502)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK5_HUMAN
NC score	0.065689 (rank : 503)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

E2AK2_MOUSE
NC score	0.065624 (rank : 504)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	106	Target Neighborhood Hits	864	Shared Neighborhood Hits	26
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

CDK6_HUMAN
NC score	0.065438 (rank : 505)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

NEK4_HUMAN
NC score	0.065436 (rank : 506)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	106	Target Neighborhood Hits	883	Shared Neighborhood Hits	26
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

YSK4_HUMAN
NC score	0.065328 (rank : 507)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	106	Target Neighborhood Hits	921	Shared Neighborhood Hits	26
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CDKL2_HUMAN
NC score	0.065315 (rank : 508)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDK6_MOUSE
NC score	0.065246 (rank : 509)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

IGS21_MOUSE
NC score	0.065222 (rank : 510)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	106	Target Neighborhood Hits	118	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

NEK4_MOUSE
NC score	0.065095 (rank : 511)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

MP2K4_HUMAN
NC score	0.065030 (rank : 512)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.064957 (rank : 513)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

STK24_HUMAN
NC score	0.064778 (rank : 514)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

FINC_HUMAN
NC score	0.064765 (rank : 515)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	106	Target Neighborhood Hits	302	Shared Neighborhood Hits	42
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

NEK6_MOUSE
NC score	0.064643 (rank : 516)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK11_MOUSE
NC score	0.064535 (rank : 517)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK24_MOUSE
NC score	0.064489 (rank : 518)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	106	Target Neighborhood Hits	856	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NEK6_HUMAN
NC score	0.064451 (rank : 519)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	106	Target Neighborhood Hits	848	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK11_HUMAN
NC score	0.064421 (rank : 520)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	106	Target Neighborhood Hits	1043	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

MAK_HUMAN
NC score	0.064391 (rank : 521)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

OX2G_MOUSE
NC score	0.064321 (rank : 522)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	106	Target Neighborhood Hits	105	Shared Neighborhood Hits	38
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

MK03_MOUSE
NC score	0.064250 (rank : 523)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

CDK4_HUMAN
NC score	0.064188 (rank : 524)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MAK_MOUSE
NC score	0.063754 (rank : 525)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MK03_HUMAN
NC score	0.063728 (rank : 526)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

NEK9_HUMAN
NC score	0.063432 (rank : 527)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	106	Target Neighborhood Hits	900	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

TEX14_HUMAN
NC score	0.063372 (rank : 528)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	106	Target Neighborhood Hits	1103	Shared Neighborhood Hits	27
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANKK1_HUMAN
NC score	0.063077 (rank : 529)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	106	Target Neighborhood Hits	1075	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

MST4_HUMAN
NC score	0.062998 (rank : 530)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

PKN1_HUMAN
NC score	0.062987 (rank : 531)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	106	Target Neighborhood Hits	886	Shared Neighborhood Hits	26
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

RIPK2_MOUSE
NC score	0.062901 (rank : 532)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	106	Target Neighborhood Hits	776	Shared Neighborhood Hits	26
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

ACVL1_MOUSE
NC score	0.062834 (rank : 533)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	106	Target Neighborhood Hits	739	Shared Neighborhood Hits	22
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

MST4_MOUSE
NC score	0.062815 (rank : 534)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MP2K7_HUMAN
NC score	0.062763 (rank : 535)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

IGS21_HUMAN
NC score	0.062751 (rank : 536)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	106	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

FCERA_MOUSE
NC score	0.062679 (rank : 537)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	106	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

PKN1_MOUSE
NC score	0.062526 (rank : 538)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	106	Target Neighborhood Hits	888	Shared Neighborhood Hits	26
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

MP2K3_HUMAN
NC score	0.062488 (rank : 539)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	106	Target Neighborhood Hits	825	Shared Neighborhood Hits	26
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

STK25_HUMAN
NC score	0.062289 (rank : 540)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
NC score	0.062235 (rank : 541)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	106	Target Neighborhood Hits	851	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK9_MOUSE
NC score	0.062179 (rank : 542)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	106	Target Neighborhood Hits	890	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

MOK_HUMAN
NC score	0.062139 (rank : 543)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	106	Target Neighborhood Hits	807	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

CDK4_MOUSE
NC score	0.061983 (rank : 544)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

TGFR2_HUMAN
NC score	0.061616 (rank : 545)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	106	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ICK_HUMAN
NC score	0.061574 (rank : 546)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MP2K3_MOUSE
NC score	0.061385 (rank : 547)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

ACVL1_HUMAN
NC score	0.061369 (rank : 548)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	106	Target Neighborhood Hits	716	Shared Neighborhood Hits	21
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

NRK_MOUSE
NC score	0.061256 (rank : 549)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PRP4B_HUMAN
NC score	0.061194 (rank : 550)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	106	Target Neighborhood Hits	1030	Shared Neighborhood Hits	27
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

MP2K6_HUMAN
NC score	0.061180 (rank : 551)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NRK_HUMAN
NC score	0.061161 (rank : 552)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	106	Target Neighborhood Hits	931	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

MOK_MOUSE
NC score	0.061152 (rank : 553)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	106	Target Neighborhood Hits	796	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

PRP4B_MOUSE
NC score	0.060979 (rank : 554)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	106	Target Neighborhood Hits	1040	Shared Neighborhood Hits	27
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

RIPK4_HUMAN
NC score	0.060945 (rank : 555)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	106	Target Neighborhood Hits	1094	Shared Neighborhood Hits	27
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

NEK2_HUMAN
NC score	0.060899 (rank : 556)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	106	Target Neighborhood Hits	908	Shared Neighborhood Hits	26
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

OXSR1_HUMAN
NC score	0.060748 (rank : 557)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NLK_HUMAN
NC score	0.060693 (rank : 558)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	106	Target Neighborhood Hits	840	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.060692 (rank : 559)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	106	Target Neighborhood Hits	839	Shared Neighborhood Hits	26
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

ICK_MOUSE
NC score	0.060520 (rank : 560)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

CDKL3_HUMAN
NC score	0.060469 (rank : 561)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

MK04_MOUSE
NC score	0.060454 (rank : 562)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	25
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

PLK1_HUMAN
NC score	0.060416 (rank : 563)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

RIPK3_MOUSE
NC score	0.060399 (rank : 564)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

OXSR1_MOUSE
NC score	0.060322 (rank : 565)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	106	Target Neighborhood Hits	865	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

MP2K6_MOUSE
NC score	0.060295 (rank : 566)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

KPCD_HUMAN
NC score	0.059929 (rank : 567)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	106	Target Neighborhood Hits	900	Shared Neighborhood Hits	26
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

USH2A_HUMAN
NC score	0.059911 (rank : 568)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	106	Target Neighborhood Hits	600	Shared Neighborhood Hits	44
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

SHPS1_HUMAN
NC score	0.059853 (rank : 569)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	106	Target Neighborhood Hits	455	Shared Neighborhood Hits	46
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

CD276_MOUSE
NC score	0.059676 (rank : 570)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	106	Target Neighborhood Hits	243	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

MK04_HUMAN
NC score	0.059499 (rank : 571)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	24
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

STK36_HUMAN
NC score	0.059439 (rank : 572)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	106	Target Neighborhood Hits	896	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

UNC5A_HUMAN
NC score	0.059416 (rank : 573)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	106	Target Neighborhood Hits	198	Shared Neighborhood Hits	58
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CDKL1_HUMAN
NC score	0.059309 (rank : 574)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

KPCD_MOUSE
NC score	0.059275 (rank : 575)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	106	Target Neighborhood Hits	888	Shared Neighborhood Hits	26
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

IKKA_MOUSE
NC score	0.059180 (rank : 576)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	26
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

TGFR2_MOUSE
NC score	0.058959 (rank : 577)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	106	Target Neighborhood Hits	748	Shared Neighborhood Hits	26
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

IKKA_HUMAN
NC score	0.058891 (rank : 578)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	106	Target Neighborhood Hits	863	Shared Neighborhood Hits	26
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

CDKL2_MOUSE
NC score	0.058890 (rank : 579)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CD2L7_HUMAN
NC score	0.058881 (rank : 580)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	106	Target Neighborhood Hits	1275	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

STK39_HUMAN
NC score	0.058881 (rank : 581)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	106	Target Neighborhood Hits	882	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
NC score	0.058791 (rank : 582)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	106	Target Neighborhood Hits	915	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK35_HUMAN
NC score	0.058770 (rank : 583)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	106	Target Neighborhood Hits	825	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_MOUSE
NC score	0.058695 (rank : 584)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	106	Target Neighborhood Hits	877	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PLK1_MOUSE
NC score	0.058647 (rank : 585)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

UNC5C_HUMAN
NC score	0.058554 (rank : 586)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	106	Target Neighborhood Hits	226	Shared Neighborhood Hits	57
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

MYLK2_HUMAN
NC score	0.058537 (rank : 587)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	106	Target Neighborhood Hits	920	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PKN2_HUMAN
NC score	0.058505 (rank : 588)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	106	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

ILRL1_MOUSE
NC score	0.058462 (rank : 589)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	106	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

PCTK2_HUMAN
NC score	0.058458 (rank : 590)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	106	Target Neighborhood Hits	837	Shared Neighborhood Hits	26
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
NC score	0.058354 (rank : 591)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	106	Target Neighborhood Hits	836	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MP2K2_HUMAN
NC score	0.058318 (rank : 592)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PKN2_MOUSE
NC score	0.058292 (rank : 593)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	106	Target Neighborhood Hits	899	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

CCRK_HUMAN
NC score	0.058241 (rank : 594)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

UNC5C_MOUSE
NC score	0.058230 (rank : 595)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

GSK3A_HUMAN
NC score	0.058201 (rank : 596)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	24
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

ULK3_HUMAN
NC score	0.058190 (rank : 597)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	106	Target Neighborhood Hits	830	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PAK1_MOUSE
NC score	0.058130 (rank : 598)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	106	Target Neighborhood Hits	878	Shared Neighborhood Hits	28
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

WEE1_MOUSE
NC score	0.058015 (rank : 599)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	106	Target Neighborhood Hits	794	Shared Neighborhood Hits	26
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

PAK1_HUMAN
NC score	0.057872 (rank : 600)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	28
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

RIPK2_HUMAN
NC score	0.057866 (rank : 601)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	106	Target Neighborhood Hits	774	Shared Neighborhood Hits	25
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

AAK1_MOUSE
NC score	0.057725 (rank : 602)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	106	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CDKL5_HUMAN
NC score	0.057696 (rank : 603)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	106	Target Neighborhood Hits	967	Shared Neighborhood Hits	26
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

GSK3B_HUMAN
NC score	0.057650 (rank : 604)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	106	Target Neighborhood Hits	801	Shared Neighborhood Hits	24
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.057649 (rank : 605)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	106	Target Neighborhood Hits	800	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

TAOK2_HUMAN
NC score	0.057621 (rank : 606)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	106	Target Neighborhood Hits	1172	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CDKL3_MOUSE
NC score	0.057598 (rank : 607)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MP2K2_MOUSE
NC score	0.057596 (rank : 608)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

SIRB1_HUMAN
NC score	0.057380 (rank : 609)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	106	Target Neighborhood Hits	422	Shared Neighborhood Hits	41
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

STK3_MOUSE
NC score	0.057317 (rank : 610)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	106	Target Neighborhood Hits	869	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CDKL4_MOUSE
NC score	0.057310 (rank : 611)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

LRRC4_MOUSE
NC score	0.057220 (rank : 612)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	106	Target Neighborhood Hits	412	Shared Neighborhood Hits	73
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

M4K4_MOUSE
NC score	0.057195 (rank : 613)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	106	Target Neighborhood Hits	1560	Shared Neighborhood Hits	27
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

OX2G_HUMAN
NC score	0.057176 (rank : 614)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	106	Target Neighborhood Hits	100	Shared Neighborhood Hits	30
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

AAK1_HUMAN
NC score	0.057172 (rank : 615)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	106	Target Neighborhood Hits	1077	Shared Neighborhood Hits	26
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

LAG3_HUMAN
NC score	0.056944 (rank : 616)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	106	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

ULK3_MOUSE
NC score	0.056893 (rank : 617)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CDKL4_HUMAN
NC score	0.056865 (rank : 618)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

NEK3_HUMAN
NC score	0.056856 (rank : 619)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	106	Target Neighborhood Hits	865	Shared Neighborhood Hits	26
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

CD2L5_HUMAN
NC score	0.056849 (rank : 620)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	106	Target Neighborhood Hits	987	Shared Neighborhood Hits	27
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

USH2A_MOUSE
NC score	0.056843 (rank : 621)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	106	Target Neighborhood Hits	626	Shared Neighborhood Hits	43
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

CD2L5_MOUSE
NC score	0.056806 (rank : 622)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	106	Target Neighborhood Hits	1011	Shared Neighborhood Hits	27
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

STK4_MOUSE
NC score	0.056786 (rank : 623)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	106	Target Neighborhood Hits	873	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

BMR1B_MOUSE
NC score	0.056778 (rank : 624)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	106	Target Neighborhood Hits	758	Shared Neighborhood Hits	23
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

STK3_HUMAN
NC score	0.056769 (rank : 625)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	106	Target Neighborhood Hits	861	Shared Neighborhood Hits	26
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PDK1L_MOUSE
NC score	0.056732 (rank : 626)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

ST17A_HUMAN
NC score	0.056705 (rank : 627)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

PAK6_HUMAN
NC score	0.056586 (rank : 628)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	106	Target Neighborhood Hits	915	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

CCRK_MOUSE
NC score	0.056537 (rank : 629)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

PINK1_MOUSE
NC score	0.056489 (rank : 630)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	106	Target Neighborhood Hits	726	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PAK2_MOUSE
NC score	0.056445 (rank : 631)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

IL6RB_HUMAN
NC score	0.056409 (rank : 632)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	106	Target Neighborhood Hits	181	Shared Neighborhood Hits	35
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

STK4_HUMAN
NC score	0.056393 (rank : 633)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	106	Target Neighborhood Hits	870	Shared Neighborhood Hits	26
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

MINK1_HUMAN
NC score	0.056304 (rank : 634)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	106	Target Neighborhood Hits	1477	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PAK2_HUMAN
NC score	0.056272 (rank : 635)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	106	Target Neighborhood Hits	862	Shared Neighborhood Hits	26
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

MINK1_MOUSE
NC score	0.056203 (rank : 636)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	106	Target Neighborhood Hits	1451	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MP2K1_MOUSE
NC score	0.056080 (rank : 637)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PDK1L_HUMAN
NC score	0.056062 (rank : 638)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

DAPK2_HUMAN
NC score	0.056044 (rank : 639)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CDKL1_MOUSE
NC score	0.055994 (rank : 640)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

TAOK2_MOUSE
NC score	0.055990 (rank : 641)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	106	Target Neighborhood Hits	1373	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

MP2K1_HUMAN
NC score	0.055977 (rank : 642)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	106	Target Neighborhood Hits	826	Shared Neighborhood Hits	26
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PCTK3_MOUSE
NC score	0.055972 (rank : 643)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PLK4_MOUSE
NC score	0.055961 (rank : 644)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	106	Target Neighborhood Hits	879	Shared Neighborhood Hits	26
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

CI096_HUMAN
NC score	0.055938 (rank : 645)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	106	Target Neighborhood Hits	821	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

PAK3_MOUSE
NC score	0.055881 (rank : 646)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.055806 (rank : 647)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	106	Target Neighborhood Hits	887	Shared Neighborhood Hits	26
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

MFAP3_MOUSE
NC score	0.055771 (rank : 648)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	106	Target Neighborhood Hits	97	Shared Neighborhood Hits	37
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

ERN1_MOUSE
NC score	0.055664 (rank : 649)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK06_MOUSE
NC score	0.055616 (rank : 650)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	106	Target Neighborhood Hits	818	Shared Neighborhood Hits	24
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

PLK4_HUMAN
NC score	0.055568 (rank : 651)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	106	Target Neighborhood Hits	884	Shared Neighborhood Hits	28
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

ULK2_MOUSE
NC score	0.055452 (rank : 652)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	106	Target Neighborhood Hits	943	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

MK06_HUMAN
NC score	0.055452 (rank : 653)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	24
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

DAPK2_MOUSE
NC score	0.055444 (rank : 654)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ULK2_HUMAN
NC score	0.055441 (rank : 655)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	106	Target Neighborhood Hits	979	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

KPCT_HUMAN
NC score	0.055376 (rank : 656)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	106	Target Neighborhood Hits	897	Shared Neighborhood Hits	26
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PCTK1_MOUSE
NC score	0.055348 (rank : 657)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	27
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

FCGR1_HUMAN
NC score	0.055290 (rank : 658)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	106	Target Neighborhood Hits	145	Shared Neighborhood Hits	45
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

MK07_MOUSE
NC score	0.055271 (rank : 659)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	106	Target Neighborhood Hits	1054	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PCTK1_HUMAN
NC score	0.055162 (rank : 660)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

KKCC2_HUMAN
NC score	0.055159 (rank : 661)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
NC score	0.055121 (rank : 662)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	106	Target Neighborhood Hits	855	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

ICAM1_MOUSE
NC score	0.055002 (rank : 663)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	106	Target Neighborhood Hits	99	Shared Neighborhood Hits	39
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

MK07_HUMAN
NC score	0.054992 (rank : 664)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	106	Target Neighborhood Hits	1087	Shared Neighborhood Hits	26
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

M3K1_MOUSE
NC score	0.054972 (rank : 665)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	106	Target Neighborhood Hits	952	Shared Neighborhood Hits	28
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K8_HUMAN
NC score	0.054761 (rank : 666)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	106	Target Neighborhood Hits	807	Shared Neighborhood Hits	24
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

HHLA2_HUMAN
NC score	0.054745 (rank : 667)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	106	Target Neighborhood Hits	140	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

KPCT_MOUSE
NC score	0.054689 (rank : 668)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	106	Target Neighborhood Hits	895	Shared Neighborhood Hits	26
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

BMP2K_HUMAN
NC score	0.054662 (rank : 669)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	106	Target Neighborhood Hits	867	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

NEK8_MOUSE
NC score	0.054585 (rank : 670)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK8_HUMAN
NC score	0.054369 (rank : 671)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	106	Target Neighborhood Hits	872	Shared Neighborhood Hits	26
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

KS6A3_HUMAN
NC score	0.054321 (rank : 672)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	106	Target Neighborhood Hits	859	Shared Neighborhood Hits	26
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
NC score	0.054313 (rank : 673)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	106	Target Neighborhood Hits	860	Shared Neighborhood Hits	26
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A1_HUMAN
NC score	0.054160 (rank : 674)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PCTK3_HUMAN
NC score	0.054144 (rank : 675)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	106	Target Neighborhood Hits	827	Shared Neighborhood Hits	26
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

GRK4_HUMAN
NC score	0.054125 (rank : 676)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	106	Target Neighborhood Hits	822	Shared Neighborhood Hits	26
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PKN3_MOUSE
NC score	0.053982 (rank : 677)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	106	Target Neighborhood Hits	1009	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

NEK1_MOUSE
NC score	0.053971 (rank : 678)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	106	Target Neighborhood Hits	1311	Shared Neighborhood Hits	26
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

DAPK3_HUMAN
NC score	0.053921 (rank : 679)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	106	Target Neighborhood Hits	945	Shared Neighborhood Hits	26
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KS6A2_HUMAN
NC score	0.053914 (rank : 680)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	106	Target Neighborhood Hits	857	Shared Neighborhood Hits	26
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MK15_HUMAN
NC score	0.053853 (rank : 681)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	106	Target Neighborhood Hits	1038	Shared Neighborhood Hits	28
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CDK3_HUMAN
NC score	0.053742 (rank : 682)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

M3K4_HUMAN
NC score	0.053687 (rank : 683)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	106	Target Neighborhood Hits	911	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

CDK7_MOUSE
NC score	0.053645 (rank : 684)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

GRK4_MOUSE
NC score	0.053638 (rank : 685)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

PKN3_HUMAN
NC score	0.053556 (rank : 686)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	106	Target Neighborhood Hits	893	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

RK_MOUSE
NC score	0.053531 (rank : 687)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ERN1_HUMAN
NC score	0.053530 (rank : 688)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	106	Target Neighborhood Hits	829	Shared Neighborhood Hits	26
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NEK1_HUMAN
NC score	0.053528 (rank : 689)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	106	Target Neighborhood Hits	1129	Shared Neighborhood Hits	26
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

CDK7_HUMAN
NC score	0.053490 (rank : 690)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

TNIK_HUMAN
NC score	0.053461 (rank : 691)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	106	Target Neighborhood Hits	1570	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

IKKB_HUMAN
NC score	0.053400 (rank : 692)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	106	Target Neighborhood Hits	980	Shared Neighborhood Hits	26
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

BMR1B_HUMAN
NC score	0.053355 (rank : 693)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	106	Target Neighborhood Hits	760	Shared Neighborhood Hits	23
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

GAK_MOUSE
NC score	0.053307 (rank : 694)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	106	Target Neighborhood Hits	964	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ULK1_HUMAN
NC score	0.053304 (rank : 695)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	106	Target Neighborhood Hits	1121	Shared Neighborhood Hits	27
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

NEK2_MOUSE
NC score	0.053300 (rank : 696)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	106	Target Neighborhood Hits	876	Shared Neighborhood Hits	26
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

DAPK3_MOUSE
NC score	0.053252 (rank : 697)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

IKKB_MOUSE
NC score	0.053215 (rank : 698)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	106	Target Neighborhood Hits	984	Shared Neighborhood Hits	26
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MK15_MOUSE
NC score	0.053200 (rank : 699)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

NEK3_MOUSE
NC score	0.053145 (rank : 700)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MK11_HUMAN
NC score	0.053079 (rank : 701)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

UNC5B_HUMAN
NC score	0.053055 (rank : 702)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	106	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

PAK7_HUMAN
NC score	0.053043 (rank : 703)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

M4K4_HUMAN
NC score	0.052928 (rank : 704)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	106	Target Neighborhood Hits	1589	Shared Neighborhood Hits	27
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KS6A2_MOUSE
NC score	0.052853 (rank : 705)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

M3K8_MOUSE
NC score	0.052713 (rank : 706)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	106	Target Neighborhood Hits	815	Shared Neighborhood Hits	24
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

ULK1_MOUSE
NC score	0.052576 (rank : 707)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	106	Target Neighborhood Hits	1214	Shared Neighborhood Hits	27
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

STK6_HUMAN
NC score	0.052561 (rank : 708)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	106	Target Neighborhood Hits	916	Shared Neighborhood Hits	26
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

ST17B_MOUSE
NC score	0.052530 (rank : 709)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

AL2S7_HUMAN
NC score	0.052512 (rank : 710)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

UNC5A_MOUSE
NC score	0.052496 (rank : 711)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	106	Target Neighborhood Hits	203	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

PAK7_MOUSE
NC score	0.052489 (rank : 712)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	106	Target Neighborhood Hits	875	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

BMR1A_MOUSE
NC score	0.052468 (rank : 713)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	106	Target Neighborhood Hits	758	Shared Neighborhood Hits	25
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1A_HUMAN
NC score	0.052455 (rank : 714)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	106	Target Neighborhood Hits	759	Shared Neighborhood Hits	25
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

PFTK1_MOUSE
NC score	0.052382 (rank : 715)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	106	Target Neighborhood Hits	835	Shared Neighborhood Hits	26
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KPCB_MOUSE
NC score	0.052148 (rank : 716)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	106	Target Neighborhood Hits	1117	Shared Neighborhood Hits	26
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PFTK1_HUMAN
NC score	0.052129 (rank : 717)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	106	Target Neighborhood Hits	834	Shared Neighborhood Hits	26
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KS6A6_HUMAN
NC score	0.051987 (rank : 718)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	106	Target Neighborhood Hits	853	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

ACVR1_MOUSE
NC score	0.051973 (rank : 719)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	106	Target Neighborhood Hits	768	Shared Neighborhood Hits	25
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

STK10_HUMAN
NC score	0.051972 (rank : 720)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	106	Target Neighborhood Hits	1921	Shared Neighborhood Hits	28
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

BMPR2_HUMAN
NC score	0.051948 (rank : 721)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	106	Target Neighborhood Hits	736	Shared Neighborhood Hits	23
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

KPCB_HUMAN
NC score	0.051901 (rank : 722)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	106	Target Neighborhood Hits	1121	Shared Neighborhood Hits	26
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

M3K4_MOUSE
NC score	0.051897 (rank : 723)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	106	Target Neighborhood Hits	924	Shared Neighborhood Hits	26
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

CDC2_HUMAN
NC score	0.051653 (rank : 724)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PLK2_HUMAN
NC score	0.051635 (rank : 725)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	106	Target Neighborhood Hits	854	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

GRK6_HUMAN
NC score	0.051534 (rank : 726)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	106	Target Neighborhood Hits	823	Shared Neighborhood Hits	26
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ACVR1_HUMAN
NC score	0.051532 (rank : 727)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	106	Target Neighborhood Hits	760	Shared Neighborhood Hits	25
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

GUC2G_MOUSE
NC score	0.051527 (rank : 728)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	106	Target Neighborhood Hits	644	Shared Neighborhood Hits	24
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

TAOK3_HUMAN
NC score	0.051452 (rank : 729)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	106	Target Neighborhood Hits	1494	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

BMP2K_MOUSE
NC score	0.051438 (rank : 730)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	106	Target Neighborhood Hits	874	Shared Neighborhood Hits	26
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

KKCC1_HUMAN
NC score	0.051394 (rank : 731)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	106	Target Neighborhood Hits	858	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KGP1A_HUMAN
NC score	0.051368 (rank : 732)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	106	Target Neighborhood Hits	901	Shared Neighborhood Hits	26
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

CDK2_MOUSE
NC score	0.051364 (rank : 733)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	106	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

UNC5B_MOUSE
NC score	0.051360 (rank : 734)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	106	Target Neighborhood Hits	226	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

KGP1B_HUMAN
NC score	0.051316 (rank : 735)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	106	Target Neighborhood Hits	921	Shared Neighborhood Hits	26
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
NC score	0.051314 (rank : 736)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	106	Target Neighborhood Hits	922	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CDK2_HUMAN
NC score	0.051268 (rank : 737)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	106	Target Neighborhood Hits	832	Shared Neighborhood Hits	26
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

ITB4_HUMAN
NC score	0.051263 (rank : 738)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	106	Target Neighborhood Hits	458	Shared Neighborhood Hits	37
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

ST17B_HUMAN
NC score	0.051214 (rank : 739)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	106	Target Neighborhood Hits	833	Shared Neighborhood Hits	26
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PLK2_MOUSE
NC score	0.051205 (rank : 740)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	106	Target Neighborhood Hits	849	Shared Neighborhood Hits	26
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

WEE1_HUMAN
NC score	0.051170 (rank : 741)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	106	Target Neighborhood Hits	777	Shared Neighborhood Hits	22
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

GAK_HUMAN
NC score	0.051010 (rank : 742)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	106	Target Neighborhood Hits	1028	Shared Neighborhood Hits	26
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MK14_HUMAN
NC score	0.050976 (rank : 743)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

STK11_HUMAN
NC score	0.050965 (rank : 744)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	106	Target Neighborhood Hits	831	Shared Neighborhood Hits	26
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

MK14_MOUSE
NC score	0.050818 (rank : 745)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	106	Target Neighborhood Hits	838	Shared Neighborhood Hits	26
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

PIM2_HUMAN
NC score	0.050784 (rank : 746)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	106	Target Neighborhood Hits	808	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

GRK6_MOUSE
NC score	0.050773 (rank : 747)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	106	Target Neighborhood Hits	820	Shared Neighborhood Hits	26
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

M3K15_HUMAN
NC score	0.050735 (rank : 748)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	106	Target Neighborhood Hits	914	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

AAPK1_HUMAN
NC score	0.050609 (rank : 749)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	106	Target Neighborhood Hits	842	Shared Neighborhood Hits	26
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KKCC1_MOUSE
NC score	0.050570 (rank : 750)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	106	Target Neighborhood Hits	866	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

TAOK3_MOUSE
NC score	0.050503 (rank : 751)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	106	Target Neighborhood Hits	1458	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TAOK1_HUMAN
NC score	0.050497 (rank : 752)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	106	Target Neighborhood Hits	1734	Shared Neighborhood Hits	27
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
NC score	0.050407 (rank : 753)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	106	Target Neighborhood Hits	1720	Shared Neighborhood Hits	27
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

LIFR_HUMAN
NC score	0.050400 (rank : 754)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	106	Target Neighborhood Hits	130	Shared Neighborhood Hits	28
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

AAPK1_MOUSE
NC score	0.050361 (rank : 755)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	106	Target Neighborhood Hits	843	Shared Neighborhood Hits	26
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

SLK_HUMAN
NC score	0.050355 (rank : 756)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	106	Target Neighborhood Hits	1775	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

IL6RB_MOUSE
NC score	0.050303 (rank : 757)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	106	Target Neighborhood Hits	168	Shared Neighborhood Hits	36
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

AMHR2_HUMAN
NC score	0.050292 (rank : 758)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	106	Target Neighborhood Hits	715	Shared Neighborhood Hits	21
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

M3K3_HUMAN
NC score	0.050227 (rank : 759)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	106	Target Neighborhood Hits	885	Shared Neighborhood Hits	27
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

KPCA_MOUSE
NC score	0.050165 (rank : 760)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	106	Target Neighborhood Hits	1067	Shared Neighborhood Hits	26
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

E2AK4_HUMAN
NC score	0.050112 (rank : 761)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	106	Target Neighborhood Hits	1012	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

PDPK1_MOUSE
NC score	0.050026 (rank : 762)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	106	Target Neighborhood Hits	852	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

REL_HUMAN
NC score	0.016612 (rank : 763)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	106	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

REL_MOUSE
NC score	0.016552 (rank : 764)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	106	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

CAN2_MOUSE
NC score	0.012358 (rank : 765)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	106	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O08529, O35518, O54843	Gene names	Capn2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (80 kDa M-calpain subunit) (CALP80).

CAN2_HUMAN
NC score	0.009240 (rank : 766)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	106	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	P17655, Q16738, Q6PJT3, Q8WU26, Q9HBB1	Gene names	CAPN2, CANPL2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2).

NFKB2_MOUSE
NC score	0.009106 (rank : 767)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	106	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NFKB2_HUMAN
NC score	0.008832 (rank : 768)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	106	Target Neighborhood Hits	325	Shared Neighborhood Hits	5
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

NPBL_MOUSE
NC score	0.007756 (rank : 769)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	106	Target Neighborhood Hits	1041	Shared Neighborhood Hits	9
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

CSMD2_HUMAN
NC score	0.004885 (rank : 770)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	106	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).