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Network neighborhood for query Sequence : SAV1_MOUSE

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SAV1_MOUSE
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SAV1_HUMAN
θ value	0 (rank : 1)	NC score	0.998967 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAGI2_HUMAN
θ value	1.09485e-13 (rank : 3)	NC score	0.461672 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	373	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	1.09485e-13 (rank : 4)	NC score	0.469224 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	370	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI1_MOUSE
θ value	2.69671e-12 (rank : 5)	NC score	0.436515 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	403	Shared Neighborhood Hits	39
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
θ value	3.52202e-12 (rank : 6)	NC score	0.437451 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	388	Shared Neighborhood Hits	39
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

ITCH_HUMAN
θ value	7.84624e-12 (rank : 7)	NC score	0.525672 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	7.84624e-12 (rank : 8)	NC score	0.528728 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	1.74796e-11 (rank : 9)	NC score	0.528156 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	1.74796e-11 (rank : 10)	NC score	0.533664 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	5.08577e-11 (rank : 11)	NC score	0.530832 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	5.08577e-11 (rank : 12)	NC score	0.531921 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWC1_HUMAN
θ value	2.13673e-09 (rank : 13)	NC score	0.542652 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	2.13673e-09 (rank : 14)	NC score	0.540240 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

NEDD4_MOUSE
θ value	4.76016e-09 (rank : 15)	NC score	0.477033 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	212	Shared Neighborhood Hits	41
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NED4L_HUMAN
θ value	8.11959e-09 (rank : 16)	NC score	0.469811 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	8.11959e-09 (rank : 17)	NC score	0.470361 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

WWOX_HUMAN
θ value	3.08544e-08 (rank : 18)	NC score	0.449809 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	115	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	3.08544e-08 (rank : 19)	NC score	0.445957 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	40
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

NEDD4_HUMAN
θ value	6.87365e-08 (rank : 20)	NC score	0.473214 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

YAP1_MOUSE
θ value	1.53129e-07 (rank : 21)	NC score	0.603615 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

PKHA5_HUMAN
θ value	1.69304e-06 (rank : 22)	NC score	0.339723 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SMUF1_MOUSE
θ value	1.69304e-06 (rank : 23)	NC score	0.473772 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	7.1131e-05 (rank : 24)	NC score	0.473292 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
θ value	0.00020696 (rank : 25)	NC score	0.454782 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

GAS7_HUMAN
θ value	0.000270298 (rank : 26)	NC score	0.299722 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

WWTR1_HUMAN
θ value	0.000602161 (rank : 27)	NC score	0.462862 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	0.000786445 (rank : 28)	NC score	0.466323 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

GAS7_MOUSE
θ value	0.00390308 (rank : 29)	NC score	0.286773 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

YAP1_HUMAN
θ value	0.00509761 (rank : 30)	NC score	0.446855 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	173	Shared Neighborhood Hits	41
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

STXB4_HUMAN
θ value	0.00665767 (rank : 31)	NC score	0.234997 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	616	Shared Neighborhood Hits	40
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00665767 (rank : 32)	NC score	0.236583 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	629	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

BAG3_HUMAN
θ value	0.0148317 (rank : 33)	NC score	0.362565 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	314	Shared Neighborhood Hits	37
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	0.0148317 (rank : 34)	NC score	0.317286 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	513	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PIN1_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.336782 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	36
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	0.365318 (rank : 36)	NC score	0.340021 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	0.47712 (rank : 37)	NC score	0.387810 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WNK2_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.005462 (rank : 120)
Query Neighborhood Hits	48	Target Neighborhood Hits	1407	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

APBB3_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.086904 (rank : 63)
Query Neighborhood Hits	48	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

ERBB2_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.002166 (rank : 122)
Query Neighborhood Hits	48	Target Neighborhood Hits	1073	Shared Neighborhood Hits	6
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

STK4_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.002854 (rank : 121)
Query Neighborhood Hits	48	Target Neighborhood Hits	870	Shared Neighborhood Hits	7
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

TRIP6_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.012216 (rank : 119)
Query Neighborhood Hits	48	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

STK3_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.002056 (rank : 124)
Query Neighborhood Hits	48	Target Neighborhood Hits	869	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.002095 (rank : 123)
Query Neighborhood Hits	48	Target Neighborhood Hits	873	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

UB7I1_MOUSE
θ value	6.88961 (rank : 45)	NC score	0.018473 (rank : 118)
Query Neighborhood Hits	48	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

DMD_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.036383 (rank : 115)
Query Neighborhood Hits	48	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.033623 (rank : 116)
Query Neighborhood Hits	48	Target Neighborhood Hits	1111	Shared Neighborhood Hits	28
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

UTRO_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.029799 (rank : 117)
Query Neighborhood Hits	48	Target Neighborhood Hits	960	Shared Neighborhood Hits	25
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

APBA3_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.050472 (rank : 111)
Query Neighborhood Hits	48	Target Neighborhood Hits	174	Shared Neighborhood Hits	6
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBB2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.094256 (rank : 61)
Query Neighborhood Hits	48	Target Neighborhood Hits	96	Shared Neighborhood Hits	22
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.077971 (rank : 64)
Query Neighborhood Hits	48	Target Neighborhood Hits	88	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB3_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.071540 (rank : 65)
Query Neighborhood Hits	48	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

CNKR2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.060427 (rank : 81)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.060549 (rank : 80)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DHRSX_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.053837 (rank : 96)
Query Neighborhood Hits	48	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

DRP2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.061809 (rank : 74)
Query Neighborhood Hits	48	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

EDD1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.190589 (rank : 54)
Query Neighborhood Hits	48	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.190821 (rank : 53)
Query Neighborhood Hits	48	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

FA62A_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.052256 (rank : 103)
Query Neighborhood Hits	48	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

GRIP1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.055582 (rank : 92)
Query Neighborhood Hits	48	Target Neighborhood Hits	231	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.052806 (rank : 101)
Query Neighborhood Hits	48	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP2_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.056342 (rank : 91)
Query Neighborhood Hits	48	Target Neighborhood Hits	256	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

HECD1_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.173769 (rank : 57)
Query Neighborhood Hits	48	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.276688 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.278289 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.191355 (rank : 52)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.194712 (rank : 51)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.179896 (rank : 56)
Query Neighborhood Hits	48	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.181978 (rank : 55)
Query Neighborhood Hits	48	Target Neighborhood Hits	167	Shared Neighborhood Hits	16
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.225043 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.230934 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.281502 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.281955 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

IL16_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.053313 (rank : 97)
Query Neighborhood Hits	48	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INADL_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.060175 (rank : 82)
Query Neighborhood Hits	48	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.060584 (rank : 79)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

K0317_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.291260 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.291089 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K1849_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.070382 (rank : 66)
Query Neighborhood Hits	48	Target Neighborhood Hits	220	Shared Neighborhood Hits	7
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

K1849_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.063964 (rank : 72)
Query Neighborhood Hits	48	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LIN7A_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.057446 (rank : 88)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.057416 (rank : 89)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7B_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.059564 (rank : 83)
Query Neighborhood Hits	48	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.060692 (rank : 78)
Query Neighborhood Hits	48	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.061127 (rank : 76)
Query Neighborhood Hits	48	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.061127 (rank : 77)
Query Neighborhood Hits	48	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LNX2_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.052405 (rank : 102)
Query Neighborhood Hits	48	Target Neighborhood Hits	389	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

MPDZ_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.065491 (rank : 70)
Query Neighborhood Hits	48	Target Neighborhood Hits	261	Shared Neighborhood Hits	6
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.061179 (rank : 75)
Query Neighborhood Hits	48	Target Neighborhood Hits	298	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

NHERF_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.050260 (rank : 112)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.052838 (rank : 100)
Query Neighborhood Hits	48	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.059263 (rank : 84)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	4
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.059090 (rank : 85)
Query Neighborhood Hits	48	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PAR3L_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.058569 (rank : 86)
Query Neighborhood Hits	48	Target Neighborhood Hits	297	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PARD3_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.065693 (rank : 69)
Query Neighborhood Hits	48	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.066797 (rank : 68)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDLI2_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.052962 (rank : 98)
Query Neighborhood Hits	48	Target Neighborhood Hits	245	Shared Neighborhood Hits	7
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PDZ11_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.051182 (rank : 108)
Query Neighborhood Hits	48	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.050089 (rank : 114)
Query Neighborhood Hits	48	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZD1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.054490 (rank : 93)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.057157 (rank : 90)
Query Neighborhood Hits	48	Target Neighborhood Hits	191	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD7_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.054322 (rank : 94)
Query Neighborhood Hits	48	Target Neighborhood Hits	181	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PRP40_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.115755 (rank : 58)
Query Neighborhood Hits	48	Target Neighborhood Hits	442	Shared Neighborhood Hits	28
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.112504 (rank : 59)
Query Neighborhood Hits	48	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

PSCBP_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.050654 (rank : 110)
Query Neighborhood Hits	48	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

RDH12_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.050171 (rank : 113)
Query Neighborhood Hits	48	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

RDH12_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.051781 (rank : 106)
Query Neighborhood Hits	48	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH14_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.051895 (rank : 104)
Query Neighborhood Hits	48	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH14_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.051308 (rank : 107)
Query Neighborhood Hits	48	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RHG12_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.058126 (rank : 87)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.068989 (rank : 67)
Query Neighborhood Hits	48	Target Neighborhood Hits	204	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SETD2_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.093543 (rank : 62)
Query Neighborhood Hits	48	Target Neighborhood Hits	412	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SYJ2B_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.065357 (rank : 71)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

TRIPC_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.250125 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	319	Shared Neighborhood Hits	14
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.269552 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.266004 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.266006 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.265007 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WBP4_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.062968 (rank : 73)
Query Neighborhood Hits	48	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WHRN_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.051060 (rank : 109)
Query Neighborhood Hits	48	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.052872 (rank : 99)
Query Neighborhood Hits	48	Target Neighborhood Hits	412	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WWC3_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.105043 (rank : 60)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

ZO3_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.053881 (rank : 95)
Query Neighborhood Hits	48	Target Neighborhood Hits	219	Shared Neighborhood Hits	6
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.051875 (rank : 105)
Query Neighborhood Hits	48	Target Neighborhood Hits	224	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

Hits sorted by NC score

SAV1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.998967 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

YAP1_MOUSE
NC score	0.603615 (rank : 3)	θ value	1.53129e-07 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

WWC1_HUMAN
NC score	0.542652 (rank : 4)	θ value	2.13673e-09 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.540240 (rank : 5)	θ value	2.13673e-09 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWP1_MOUSE
NC score	0.533664 (rank : 6)	θ value	1.74796e-11 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.531921 (rank : 7)	θ value	5.08577e-11 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.530832 (rank : 8)	θ value	5.08577e-11 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	177	Shared Neighborhood Hits	41
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

ITCH_MOUSE
NC score	0.528728 (rank : 9)	θ value	7.84624e-12 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
NC score	0.528156 (rank : 10)	θ value	1.74796e-11 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_HUMAN
NC score	0.525672 (rank : 11)	θ value	7.84624e-12 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NEDD4_MOUSE
NC score	0.477033 (rank : 12)	θ value	4.76016e-09 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	212	Shared Neighborhood Hits	41
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF1_MOUSE
NC score	0.473772 (rank : 13)	θ value	1.69304e-06 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.473292 (rank : 14)	θ value	7.1131e-05 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NEDD4_HUMAN
NC score	0.473214 (rank : 15)	θ value	6.87365e-08 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.470361 (rank : 16)	θ value	8.11959e-09 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.469811 (rank : 17)	θ value	8.11959e-09 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

MAGI2_MOUSE
NC score	0.469224 (rank : 18)	θ value	1.09485e-13 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	370	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

WWTR1_MOUSE
NC score	0.466323 (rank : 19)	θ value	0.000786445 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.462862 (rank : 20)	θ value	0.000602161 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

MAGI2_HUMAN
NC score	0.461672 (rank : 21)	θ value	1.09485e-13 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	373	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SMUF1_HUMAN
NC score	0.454782 (rank : 22)	θ value	0.00020696 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

WWOX_HUMAN
NC score	0.449809 (rank : 23)	θ value	3.08544e-08 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	115	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

YAP1_HUMAN
NC score	0.446855 (rank : 24)	θ value	0.00509761 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	173	Shared Neighborhood Hits	41
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

WWOX_MOUSE
NC score	0.445957 (rank : 25)	θ value	3.08544e-08 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	40
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

MAGI1_HUMAN
NC score	0.437451 (rank : 26)	θ value	3.52202e-12 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	388	Shared Neighborhood Hits	39
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.436515 (rank : 27)	θ value	2.69671e-12 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	403	Shared Neighborhood Hits	39
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PINL_HUMAN
NC score	0.387810 (rank : 28)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

BAG3_HUMAN
NC score	0.362565 (rank : 29)	θ value	0.0148317 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	314	Shared Neighborhood Hits	37
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

PIN1_MOUSE
NC score	0.340021 (rank : 30)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PKHA5_HUMAN
NC score	0.339723 (rank : 31)	θ value	1.69304e-06 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PIN1_HUMAN
NC score	0.336782 (rank : 32)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	36
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

BAG3_MOUSE
NC score	0.317286 (rank : 33)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	513	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

GAS7_HUMAN
NC score	0.299722 (rank : 34)	θ value	0.000270298 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

K0317_HUMAN
NC score	0.291260 (rank : 35)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	48	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.291089 (rank : 36)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	48	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

GAS7_MOUSE
NC score	0.286773 (rank : 37)	θ value	0.00390308 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

HUWE1_MOUSE
NC score	0.281955 (rank : 38)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	48	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.281502 (rank : 39)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	48	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.278289 (rank : 40)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	48	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.276688 (rank : 41)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	48	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.269552 (rank : 42)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
NC score	0.266006 (rank : 43)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	48	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
NC score	0.266004 (rank : 44)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_MOUSE
NC score	0.265007 (rank : 45)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.250125 (rank : 46)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	48	Target Neighborhood Hits	319	Shared Neighborhood Hits	14
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

STXB4_MOUSE
NC score	0.236583 (rank : 47)	θ value	0.00665767 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	629	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.234997 (rank : 48)	θ value	0.00665767 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	616	Shared Neighborhood Hits	40
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

HERC5_HUMAN
NC score	0.230934 (rank : 49)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	48	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.225043 (rank : 50)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.194712 (rank : 51)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	48	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.191355 (rank : 52)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	48	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.190821 (rank : 53)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	48	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.190589 (rank : 54)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	48	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.181978 (rank : 55)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	48	Target Neighborhood Hits	167	Shared Neighborhood Hits	16
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.179896 (rank : 56)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	48	Target Neighborhood Hits	163	Shared Neighborhood Hits	16
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.173769 (rank : 57)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	48	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

PRP40_HUMAN
NC score	0.115755 (rank : 58)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	48	Target Neighborhood Hits	442	Shared Neighborhood Hits	28
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.112504 (rank : 59)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	48	Target Neighborhood Hits	447	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

WWC3_HUMAN
NC score	0.105043 (rank : 60)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

APBB2_HUMAN
NC score	0.094256 (rank : 61)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	96	Shared Neighborhood Hits	22
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

SETD2_HUMAN
NC score	0.093543 (rank : 62)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	48	Target Neighborhood Hits	412	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

APBB3_HUMAN
NC score	0.086904 (rank : 63)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB2_MOUSE
NC score	0.077971 (rank : 64)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	48	Target Neighborhood Hits	88	Shared Neighborhood Hits	18
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB3_MOUSE
NC score	0.071540 (rank : 65)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	48	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

K1849_HUMAN
NC score	0.070382 (rank : 66)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	48	Target Neighborhood Hits	220	Shared Neighborhood Hits	7
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

RHG12_MOUSE
NC score	0.068989 (rank : 67)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	48	Target Neighborhood Hits	204	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PARD3_MOUSE
NC score	0.066797 (rank : 68)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
NC score	0.065693 (rank : 69)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	48	Target Neighborhood Hits	312	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

MPDZ_HUMAN
NC score	0.065491 (rank : 70)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	48	Target Neighborhood Hits	261	Shared Neighborhood Hits	6
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

SYJ2B_HUMAN
NC score	0.065357 (rank : 71)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	6
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

K1849_MOUSE
NC score	0.063964 (rank : 72)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	48	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

WBP4_MOUSE
NC score	0.062968 (rank : 73)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	48	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

DRP2_HUMAN
NC score	0.061809 (rank : 74)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	48	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

MPDZ_MOUSE
NC score	0.061179 (rank : 75)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	48	Target Neighborhood Hits	298	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

LIN7C_HUMAN
NC score	0.061127 (rank : 76)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	48	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.061127 (rank : 77)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	48	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7B_MOUSE
NC score	0.060692 (rank : 78)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	48	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

INADL_MOUSE
NC score	0.060584 (rank : 79)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

CNKR2_MOUSE
NC score	0.060549 (rank : 80)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.060427 (rank : 81)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

INADL_HUMAN
NC score	0.060175 (rank : 82)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	48	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LIN7B_HUMAN
NC score	0.059564 (rank : 83)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	48	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

NHRF2_HUMAN
NC score	0.059263 (rank : 84)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	48	Target Neighborhood Hits	197	Shared Neighborhood Hits	4
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.059090 (rank : 85)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	48	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PAR3L_HUMAN
NC score	0.058569 (rank : 86)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	48	Target Neighborhood Hits	297	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

RHG12_HUMAN
NC score	0.058126 (rank : 87)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

LIN7A_HUMAN
NC score	0.057446 (rank : 88)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.057416 (rank : 89)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	48	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

PDZD1_MOUSE
NC score	0.057157 (rank : 90)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	48	Target Neighborhood Hits	191	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

GRIP2_HUMAN
NC score	0.056342 (rank : 91)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	48	Target Neighborhood Hits	256	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRIP1_HUMAN
NC score	0.055582 (rank : 92)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	48	Target Neighborhood Hits	231	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

PDZD1_HUMAN
NC score	0.054490 (rank : 93)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD7_HUMAN
NC score	0.054322 (rank : 94)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	48	Target Neighborhood Hits	181	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

ZO3_HUMAN
NC score	0.053881 (rank : 95)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	48	Target Neighborhood Hits	219	Shared Neighborhood Hits	6
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

DHRSX_HUMAN
NC score	0.053837 (rank : 96)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	48	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

IL16_HUMAN
NC score	0.053313 (rank : 97)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	48	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PDLI2_HUMAN
NC score	0.052962 (rank : 98)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	48	Target Neighborhood Hits	245	Shared Neighborhood Hits	7
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

WHRN_MOUSE
NC score	0.052872 (rank : 99)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	48	Target Neighborhood Hits	412	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

NHERF_MOUSE
NC score	0.052838 (rank : 100)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	48	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

GRIP1_MOUSE
NC score	0.052806 (rank : 101)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	48	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LNX2_HUMAN
NC score	0.052405 (rank : 102)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	48	Target Neighborhood Hits	389	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

FA62A_MOUSE
NC score	0.052256 (rank : 103)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	48	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RDH14_HUMAN
NC score	0.051895 (rank : 104)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	48	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

ZO3_MOUSE
NC score	0.051875 (rank : 105)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	48	Target Neighborhood Hits	224	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

RDH12_MOUSE
NC score	0.051781 (rank : 106)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	48	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH14_MOUSE
NC score	0.051308 (rank : 107)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	48	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

PDZ11_HUMAN
NC score	0.051182 (rank : 108)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	48	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

WHRN_HUMAN
NC score	0.051060 (rank : 109)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	48	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

PSCBP_HUMAN
NC score	0.050654 (rank : 110)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	48	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

APBA3_MOUSE
NC score	0.050472 (rank : 111)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	174	Shared Neighborhood Hits	6
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

NHERF_HUMAN
NC score	0.050260 (rank : 112)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	48	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

RDH12_HUMAN
NC score	0.050171 (rank : 113)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	48	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

PDZ11_MOUSE
NC score	0.050089 (rank : 114)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	48	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

DMD_HUMAN
NC score	0.036383 (rank : 115)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
NC score	0.033623 (rank : 116)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	1111	Shared Neighborhood Hits	28
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

UTRO_HUMAN
NC score	0.029799 (rank : 117)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	960	Shared Neighborhood Hits	25
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

UB7I1_MOUSE
NC score	0.018473 (rank : 118)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

TRIP6_HUMAN
NC score	0.012216 (rank : 119)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

WNK2_HUMAN
NC score	0.005462 (rank : 120)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	1407	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

STK4_HUMAN
NC score	0.002854 (rank : 121)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	870	Shared Neighborhood Hits	7
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

ERBB2_HUMAN
NC score	0.002166 (rank : 122)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	1073	Shared Neighborhood Hits	6
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

STK4_MOUSE
NC score	0.002095 (rank : 123)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	873	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK3_MOUSE
NC score	0.002056 (rank : 124)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	869	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).