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Network neighborhood for query Sequence : WWP2_MOUSE

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WWP2_MOUSE
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITCH_HUMAN
θ value	0 (rank : 1)	NC score	0.983732 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	76
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0 (rank : 2)	NC score	0.991499 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	127	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0 (rank : 3)	NC score	0.983562 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	262	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	0 (rank : 4)	NC score	0.991677 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	0 (rank : 5)	NC score	0.994554 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	92
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NEDD4_HUMAN
θ value	2.42647e-146 (rank : 7)	NC score	0.914036 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	214	Shared Neighborhood Hits	80
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
θ value	1.52337e-140 (rank : 8)	NC score	0.897837 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	238	Shared Neighborhood Hits	82
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	1.52337e-140 (rank : 9)	NC score	0.898841 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	231	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SMUF2_HUMAN
θ value	2.689e-137 (rank : 10)	NC score	0.963000 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NEDD4_MOUSE
θ value	2.97304e-136 (rank : 11)	NC score	0.917542 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	81
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF1_HUMAN
θ value	9.26343e-130 (rank : 12)	NC score	0.951515 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	4.75757e-126 (rank : 13)	NC score	0.955063 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

HUWE1_HUMAN
θ value	1.14559e-87 (rank : 14)	NC score	0.868436 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	1.14559e-87 (rank : 15)	NC score	0.869926 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	406	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

UBE3A_HUMAN
θ value	1.66964e-54 (rank : 16)	NC score	0.879144 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HECD2_MOUSE
θ value	1.41344e-53 (rank : 17)	NC score	0.885291 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
θ value	5.93839e-52 (rank : 18)	NC score	0.882429 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
θ value	5.02714e-51 (rank : 19)	NC score	0.879201 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	2.49495e-50 (rank : 20)	NC score	0.878636 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_MOUSE
θ value	3.2585e-50 (rank : 21)	NC score	0.872780 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HERC3_HUMAN
θ value	7.77379e-44 (rank : 22)	NC score	0.728225 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

UBE3C_HUMAN
θ value	1.32601e-43 (rank : 23)	NC score	0.860329 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	1.91475e-42 (rank : 24)	NC score	0.858723 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
θ value	2.77131e-33 (rank : 25)	NC score	0.797781 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
θ value	3.61944e-33 (rank : 26)	NC score	0.731582 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC2_MOUSE
θ value	5.77852e-31 (rank : 27)	NC score	0.620410 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	38
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
θ value	2.19584e-30 (rank : 28)	NC score	0.616294 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
θ value	6.84181e-24 (rank : 29)	NC score	0.563211 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	371	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD3_MOUSE
θ value	1.058e-16 (rank : 30)	NC score	0.696137 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	6.85773e-16 (rank : 31)	NC score	0.690792 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_HUMAN
θ value	9.90251e-15 (rank : 32)	NC score	0.652649 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	9.90251e-15 (rank : 33)	NC score	0.654237 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	36
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

MAGI1_HUMAN
θ value	3.76295e-14 (rank : 34)	NC score	0.309802 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	388	Shared Neighborhood Hits	49
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

WWC1_HUMAN
θ value	8.38298e-14 (rank : 35)	NC score	0.448802 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	8.38298e-14 (rank : 36)	NC score	0.447809 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

YAP1_MOUSE
θ value	1.86753e-13 (rank : 37)	NC score	0.557338 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

MAGI2_MOUSE
θ value	3.18553e-13 (rank : 38)	NC score	0.329031 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	370	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

WWOX_HUMAN
θ value	4.16044e-13 (rank : 39)	NC score	0.399357 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	4.16044e-13 (rank : 40)	NC score	0.395927 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

MAGI1_MOUSE
θ value	1.02475e-11 (rank : 41)	NC score	0.308926 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	403	Shared Neighborhood Hits	54
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

SAV1_HUMAN
θ value	5.08577e-11 (rank : 42)	NC score	0.532411 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	5.08577e-11 (rank : 43)	NC score	0.531921 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

MAGI2_HUMAN
θ value	1.47974e-10 (rank : 44)	NC score	0.315036 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	373	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

PKHA5_HUMAN
θ value	3.08544e-08 (rank : 45)	NC score	0.284196 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

APBB2_HUMAN
θ value	1.17247e-07 (rank : 46)	NC score	0.194846 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

PRP40_MOUSE
θ value	1.43324e-05 (rank : 47)	NC score	0.219500 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	447	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

BAG3_HUMAN
θ value	2.44474e-05 (rank : 48)	NC score	0.353806 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	2.44474e-05 (rank : 49)	NC score	0.305791 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	513	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PINL_HUMAN
θ value	3.19293e-05 (rank : 50)	NC score	0.452552 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWTR1_HUMAN
θ value	3.19293e-05 (rank : 51)	NC score	0.381136 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	3.19293e-05 (rank : 52)	NC score	0.383664 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

APBB2_MOUSE
θ value	4.1701e-05 (rank : 53)	NC score	0.182589 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

PRP40_HUMAN
θ value	4.1701e-05 (rank : 54)	NC score	0.220938 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	442	Shared Neighborhood Hits	46
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PIN1_HUMAN
θ value	5.44631e-05 (rank : 55)	NC score	0.388833 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	5.44631e-05 (rank : 56)	NC score	0.391441 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

GAS7_HUMAN
θ value	9.29e-05 (rank : 57)	NC score	0.266146 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	258	Shared Neighborhood Hits	48
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

YAP1_HUMAN
θ value	9.29e-05 (rank : 58)	NC score	0.378511 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	52
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

GAS7_MOUSE
θ value	0.000158464 (rank : 59)	NC score	0.264170 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	259	Shared Neighborhood Hits	46
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

RHG12_MOUSE
θ value	0.000158464 (rank : 60)	NC score	0.124337 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_HUMAN
θ value	0.00102713 (rank : 61)	NC score	0.110192 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	190	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

STXB4_HUMAN
θ value	0.00134147 (rank : 62)	NC score	0.178512 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	616	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00175202 (rank : 63)	NC score	0.179267 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	629	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

CEP68_HUMAN
θ value	0.00298849 (rank : 64)	NC score	0.045611 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	128	Shared Neighborhood Hits	10
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

SETD2_HUMAN
θ value	0.0113563 (rank : 65)	NC score	0.137519 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

TGON2_HUMAN
θ value	0.0736092 (rank : 66)	NC score	0.037723 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

APBB1_HUMAN
θ value	0.0961366 (rank : 67)	NC score	0.110924 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	23
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	0.0961366 (rank : 68)	NC score	0.110383 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

MAP1B_MOUSE
θ value	0.0961366 (rank : 69)	NC score	0.027426 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	977	Shared Neighborhood Hits	22
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

APBB3_HUMAN
θ value	0.163984 (rank : 70)	NC score	0.146243 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	0.163984 (rank : 71)	NC score	0.145584 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

MAP1B_HUMAN
θ value	0.163984 (rank : 72)	NC score	0.028009 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	903	Shared Neighborhood Hits	28
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

NU214_HUMAN
θ value	0.163984 (rank : 73)	NC score	0.040247 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	657	Shared Neighborhood Hits	20
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

SOX6_MOUSE
θ value	0.21417 (rank : 74)	NC score	0.014873 (rank : 145)
Query Neighborhood Hits	118	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

DMD_HUMAN
θ value	0.279714 (rank : 75)	NC score	0.046980 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	0.279714 (rank : 76)	NC score	0.042908 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	1111	Shared Neighborhood Hits	42
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

TCRG1_MOUSE
θ value	0.279714 (rank : 77)	NC score	0.080844 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

ERCC6_HUMAN
θ value	0.365318 (rank : 78)	NC score	0.008803 (rank : 153)
Query Neighborhood Hits	118	Target Neighborhood Hits	247	Shared Neighborhood Hits	9
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

MORN3_HUMAN
θ value	0.365318 (rank : 79)	NC score	0.026314 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MAGE1_HUMAN
θ value	0.47712 (rank : 80)	NC score	0.028142 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	1389	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

UTRO_HUMAN
θ value	0.47712 (rank : 81)	NC score	0.038803 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	960	Shared Neighborhood Hits	37
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

WBP4_MOUSE
θ value	0.62314 (rank : 82)	NC score	0.118548 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	33
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

KI67_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.022392 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	581	Shared Neighborhood Hits	17
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

DRP2_HUMAN
θ value	1.06291 (rank : 84)	NC score	0.091627 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	186	Shared Neighborhood Hits	26
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

NFH_MOUSE
θ value	1.06291 (rank : 85)	NC score	0.018094 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	2247	Shared Neighborhood Hits	37
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SOX6_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.010542 (rank : 150)
Query Neighborhood Hits	118	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

STRN3_HUMAN
θ value	1.06291 (rank : 87)	NC score	0.004753 (rank : 158)
Query Neighborhood Hits	118	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

TCRG1_HUMAN
θ value	1.06291 (rank : 88)	NC score	0.079923 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	929	Shared Neighborhood Hits	40
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

DNS2A_HUMAN
θ value	1.38821 (rank : 89)	NC score	0.012888 (rank : 146)
Query Neighborhood Hits	118	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O00115, O43910	Gene names	DNASE2, DNASE2A, DNL2
Domain Architecture
Description	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2).

MAGB6_HUMAN
θ value	1.38821 (rank : 90)	NC score	0.008995 (rank : 152)
Query Neighborhood Hits	118	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

E2AK3_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.000698 (rank : 162)
Query Neighborhood Hits	118	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

IGHA1_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.005028 (rank : 157)
Query Neighborhood Hits	118	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	P01876	Gene names	IGHA1
Domain Architecture
Description	Ig alpha-1 chain C region.

PA24A_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.041898 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

FBX46_MOUSE
θ value	3.0926 (rank : 94)	NC score	0.008326 (rank : 154)
Query Neighborhood Hits	118	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

OTOF_MOUSE
θ value	3.0926 (rank : 95)	NC score	0.036200 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

LEUK_MOUSE
θ value	4.03905 (rank : 96)	NC score	0.018296 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	P15702	Gene names	Spn
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Ly- 48) (B cell differentiation antigen LP-3) (CD43 antigen).

MTR1L_HUMAN
θ value	4.03905 (rank : 97)	NC score	-0.004935 (rank : 168)
Query Neighborhood Hits	118	Target Neighborhood Hits	1180	Shared Neighborhood Hits	8
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

PA24A_MOUSE
θ value	4.03905 (rank : 98)	NC score	0.047565 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PCLO_MOUSE
θ value	4.03905 (rank : 99)	NC score	0.054328 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	2275	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PTPRF_HUMAN
θ value	4.03905 (rank : 100)	NC score	-0.001965 (rank : 163)
Query Neighborhood Hits	118	Target Neighborhood Hits	489	Shared Neighborhood Hits	4
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

RECQ4_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.004127 (rank : 159)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

SUHW4_MOUSE
θ value	4.03905 (rank : 102)	NC score	-0.002227 (rank : 165)
Query Neighborhood Hits	118	Target Neighborhood Hits	737	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FE8, Q3T9B1, Q8BI82	Gene names	Suhw4
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

E2AK3_MOUSE
θ value	5.27518 (rank : 103)	NC score	-0.002044 (rank : 164)
Query Neighborhood Hits	118	Target Neighborhood Hits	851	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

PALM_MOUSE
θ value	5.27518 (rank : 104)	NC score	0.012229 (rank : 148)
Query Neighborhood Hits	118	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

PF21B_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.009071 (rank : 151)
Query Neighborhood Hits	118	Target Neighborhood Hits	278	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

RFIP5_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.006879 (rank : 156)
Query Neighborhood Hits	118	Target Neighborhood Hits	126	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

TARA_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.026980 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	1626	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CSPG5_MOUSE
θ value	6.88961 (rank : 108)	NC score	0.007815 (rank : 155)
Query Neighborhood Hits	118	Target Neighborhood Hits	211	Shared Neighborhood Hits	6
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

FILA_HUMAN
θ value	6.88961 (rank : 109)	NC score	0.015154 (rank : 144)
Query Neighborhood Hits	118	Target Neighborhood Hits	685	Shared Neighborhood Hits	22
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

FZD6_MOUSE
θ value	6.88961 (rank : 110)	NC score	0.002977 (rank : 161)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

GRIN1_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.017550 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

TITIN_HUMAN
θ value	6.88961 (rank : 112)	NC score	-0.002803 (rank : 167)
Query Neighborhood Hits	118	Target Neighborhood Hits	2923	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

AMOL1_MOUSE
θ value	8.99809 (rank : 113)	NC score	0.003449 (rank : 160)
Query Neighborhood Hits	118	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

DACT1_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.012548 (rank : 147)
Query Neighborhood Hits	118	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

OXSR1_HUMAN
θ value	8.99809 (rank : 115)	NC score	-0.006219 (rank : 169)
Query Neighborhood Hits	118	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

SSPO_MOUSE
θ value	8.99809 (rank : 116)	NC score	-0.002725 (rank : 166)
Query Neighborhood Hits	118	Target Neighborhood Hits	800	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SYT13_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.016039 (rank : 143)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	8.99809 (rank : 118)	NC score	0.011698 (rank : 149)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

ALS2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.054736 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.053052 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CUL7_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.057695 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

DGCR8_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.063374 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.061463 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DOC2A_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.061900 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	144	Shared Neighborhood Hits	14
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.066067 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.063593 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.062441 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.050114 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

FA62A_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.075089 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.089884 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

K1333_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.063931 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

MYOF_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.050253 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

PA24B_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.059677 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PCLO_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.051324 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	2046	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RASL1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.070951 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.066971 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.063542 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RCBT1_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.060942 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.062575 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.067069 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.067988 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.081952 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.079933 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.084536 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.084066 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RIMS2_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.062274 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	342	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.061736 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	376	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RP3A_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.052289 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	305	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RPGR_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.084798 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.080708 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SRGEF_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.087886 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.085529 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SYT10_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.052611 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.051146 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.053961 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.053960 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT5_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.055281 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	15
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT7_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.052767 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	13
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.052260 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

TOLIP_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.063005 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

TOLIP_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.067632 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

UN13A_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.078503 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.081363 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.081300 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	210	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13D_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.056023 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WBP4_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.053483 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	86	Shared Neighborhood Hits	18
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WBS16_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.077754 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.079430 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWC3_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.053837 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

Hits sorted by NC score

WWP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.994554 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	92
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_MOUSE
NC score	0.991677 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
NC score	0.991499 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	127	Shared Neighborhood Hits	74
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.983732 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	76
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_HUMAN
NC score	0.983562 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	262	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

SMUF2_HUMAN
NC score	0.963000 (rank : 7)	θ value	2.689e-137 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.955063 (rank : 8)	θ value	4.75757e-126 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
NC score	0.951515 (rank : 9)	θ value	9.26343e-130 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_MOUSE
NC score	0.917542 (rank : 10)	θ value	2.97304e-136 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	81
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.914036 (rank : 11)	θ value	2.42647e-146 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	214	Shared Neighborhood Hits	80
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.898841 (rank : 12)	θ value	1.52337e-140 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	231	Shared Neighborhood Hits	81
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.897837 (rank : 13)	θ value	1.52337e-140 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	238	Shared Neighborhood Hits	82
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HECD2_MOUSE
NC score	0.885291 (rank : 14)	θ value	1.41344e-53 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.882429 (rank : 15)	θ value	5.93839e-52 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	33
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
NC score	0.879201 (rank : 16)	θ value	5.02714e-51 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_HUMAN
NC score	0.879144 (rank : 17)	θ value	1.66964e-54 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

K0317_MOUSE
NC score	0.878636 (rank : 18)	θ value	2.49495e-50 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	43	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

UBE3A_MOUSE
NC score	0.872780 (rank : 19)	θ value	3.2585e-50 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HUWE1_MOUSE
NC score	0.869926 (rank : 20)	θ value	1.14559e-87 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	406	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.868436 (rank : 21)	θ value	1.14559e-87 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	45
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

UBE3C_HUMAN
NC score	0.860329 (rank : 22)	θ value	1.32601e-43 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.858723 (rank : 23)	θ value	1.91475e-42 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	33
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.797781 (rank : 24)	θ value	2.77131e-33 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.731582 (rank : 25)	θ value	3.61944e-33 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.728225 (rank : 26)	θ value	7.77379e-44 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.696137 (rank : 27)	θ value	1.058e-16 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.690792 (rank : 28)	θ value	6.85773e-16 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.654237 (rank : 29)	θ value	9.90251e-15 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	36
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.652649 (rank : 30)	θ value	9.90251e-15 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	170	Shared Neighborhood Hits	34
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.620410 (rank : 31)	θ value	5.77852e-31 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	38
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.616294 (rank : 32)	θ value	2.19584e-30 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.563211 (rank : 33)	θ value	6.84181e-24 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	371	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.557338 (rank : 34)	θ value	1.86753e-13 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.532411 (rank : 35)	θ value	5.08577e-11 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.531921 (rank : 36)	θ value	5.08577e-11 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

PINL_HUMAN
NC score	0.452552 (rank : 37)	θ value	3.19293e-05 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	44
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWC1_HUMAN
NC score	0.448802 (rank : 38)	θ value	8.38298e-14 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.447809 (rank : 39)	θ value	8.38298e-14 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
NC score	0.399357 (rank : 40)	θ value	4.16044e-13 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.395927 (rank : 41)	θ value	4.16044e-13 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PIN1_MOUSE
NC score	0.391441 (rank : 42)	θ value	5.44631e-05 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	60	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.388833 (rank : 43)	θ value	5.44631e-05 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWTR1_MOUSE
NC score	0.383664 (rank : 44)	θ value	3.19293e-05 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.381136 (rank : 45)	θ value	3.19293e-05 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.378511 (rank : 46)	θ value	9.29e-05 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	52
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_HUMAN
NC score	0.353806 (rank : 47)	θ value	2.44474e-05 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

MAGI2_MOUSE
NC score	0.329031 (rank : 48)	θ value	3.18553e-13 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	370	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.315036 (rank : 49)	θ value	1.47974e-10 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	373	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_HUMAN
NC score	0.309802 (rank : 50)	θ value	3.76295e-14 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	388	Shared Neighborhood Hits	49
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.308926 (rank : 51)	θ value	1.02475e-11 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	403	Shared Neighborhood Hits	54
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

BAG3_MOUSE
NC score	0.305791 (rank : 52)	θ value	2.44474e-05 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	513	Shared Neighborhood Hits	48
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PKHA5_HUMAN
NC score	0.284196 (rank : 53)	θ value	3.08544e-08 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	455	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAS7_HUMAN
NC score	0.266146 (rank : 54)	θ value	9.29e-05 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	258	Shared Neighborhood Hits	48
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.264170 (rank : 55)	θ value	0.000158464 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	259	Shared Neighborhood Hits	46
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PRP40_HUMAN
NC score	0.220938 (rank : 56)	θ value	4.1701e-05 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	442	Shared Neighborhood Hits	46
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.219500 (rank : 57)	θ value	1.43324e-05 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	447	Shared Neighborhood Hits	45
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

APBB2_HUMAN
NC score	0.194846 (rank : 58)	θ value	1.17247e-07 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	31
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
NC score	0.182589 (rank : 59)	θ value	4.1701e-05 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

STXB4_MOUSE
NC score	0.179267 (rank : 60)	θ value	0.00175202 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	629	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.178512 (rank : 61)	θ value	0.00134147 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	616	Shared Neighborhood Hits	44
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBB3_HUMAN
NC score	0.146243 (rank : 62)	θ value	0.163984 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.145584 (rank : 63)	θ value	0.163984 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

SETD2_HUMAN
NC score	0.137519 (rank : 64)	θ value	0.0113563 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	412	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

RHG12_MOUSE
NC score	0.124337 (rank : 65)	θ value	0.000158464 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	204	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

WBP4_MOUSE
NC score	0.118548 (rank : 66)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	33
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

APBB1_HUMAN
NC score	0.110924 (rank : 67)	θ value	0.0961366 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	23
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.110383 (rank : 68)	θ value	0.0961366 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

RHG12_HUMAN
NC score	0.110192 (rank : 69)	θ value	0.00102713 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	190	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DRP2_HUMAN
NC score	0.091627 (rank : 70)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	186	Shared Neighborhood Hits	26
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

FA62A_MOUSE
NC score	0.089884 (rank : 71)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SRGEF_HUMAN
NC score	0.087886 (rank : 72)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	118	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
NC score	0.085529 (rank : 73)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RPGR_HUMAN
NC score	0.084798 (rank : 74)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	118	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCC2_HUMAN
NC score	0.084536 (rank : 75)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	118	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
NC score	0.084066 (rank : 76)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RCC1_HUMAN
NC score	0.081952 (rank : 77)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

UN13B_HUMAN
NC score	0.081363 (rank : 78)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	118	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
NC score	0.081300 (rank : 79)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	118	Target Neighborhood Hits	210	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

TCRG1_MOUSE
NC score	0.080844 (rank : 80)	θ value	0.279714 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	947	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

RPGR_MOUSE
NC score	0.080708 (rank : 81)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	118	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RCC1_MOUSE
NC score	0.079933 (rank : 82)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	118	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

TCRG1_HUMAN
NC score	0.079923 (rank : 83)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	929	Shared Neighborhood Hits	40
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

WBS16_MOUSE
NC score	0.079430 (rank : 84)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

UN13A_HUMAN
NC score	0.078503 (rank : 85)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	118	Target Neighborhood Hits	285	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

WBS16_HUMAN
NC score	0.077754 (rank : 86)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	118	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

FA62A_HUMAN
NC score	0.075089 (rank : 87)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	168	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL1_HUMAN
NC score	0.070951 (rank : 88)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RCBT2_MOUSE
NC score	0.067988 (rank : 89)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

TOLIP_MOUSE
NC score	0.067632 (rank : 90)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	118	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

RCBT2_HUMAN
NC score	0.067069 (rank : 91)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RASL1_MOUSE
NC score	0.066971 (rank : 92)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

DOC2A_MOUSE
NC score	0.066067 (rank : 93)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

K1333_MOUSE
NC score	0.063931 (rank : 94)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

DOC2B_HUMAN
NC score	0.063593 (rank : 95)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RASL2_HUMAN
NC score	0.063542 (rank : 96)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

DGCR8_HUMAN
NC score	0.063374 (rank : 97)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

TOLIP_HUMAN
NC score	0.063005 (rank : 98)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	118	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

RCBT1_MOUSE
NC score	0.062575 (rank : 99)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

DOC2B_MOUSE
NC score	0.062441 (rank : 100)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	17
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RIMS2_HUMAN
NC score	0.062274 (rank : 101)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	118	Target Neighborhood Hits	342	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

DOC2A_HUMAN
NC score	0.061900 (rank : 102)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	144	Shared Neighborhood Hits	14
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

RIMS2_MOUSE
NC score	0.061736 (rank : 103)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	118	Target Neighborhood Hits	376	Shared Neighborhood Hits	25
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

DGCR8_MOUSE
NC score	0.061463 (rank : 104)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

RCBT1_HUMAN
NC score	0.060942 (rank : 105)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

PA24B_MOUSE
NC score	0.059677 (rank : 106)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CUL7_HUMAN
NC score	0.057695 (rank : 107)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

UN13D_HUMAN
NC score	0.056023 (rank : 108)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	118	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

SYT5_HUMAN
NC score	0.055281 (rank : 109)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	15
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

ALS2_HUMAN
NC score	0.054736 (rank : 110)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

PCLO_MOUSE
NC score	0.054328 (rank : 111)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	2275	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT1_HUMAN
NC score	0.053961 (rank : 112)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.053960 (rank : 113)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	118	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

WWC3_HUMAN
NC score	0.053837 (rank : 114)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	118	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

WBP4_HUMAN
NC score	0.053483 (rank : 115)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	118	Target Neighborhood Hits	86	Shared Neighborhood Hits	18
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

ALS2_MOUSE
NC score	0.053052 (rank : 116)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	111	Shared Neighborhood Hits	5
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SYT7_HUMAN
NC score	0.052767 (rank : 117)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	13
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT10_HUMAN
NC score	0.052611 (rank : 118)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	118	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

RP3A_HUMAN
NC score	0.052289 (rank : 119)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	118	Target Neighborhood Hits	305	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT7_MOUSE
NC score	0.052260 (rank : 120)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

PCLO_HUMAN
NC score	0.051324 (rank : 121)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	2046	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYT10_MOUSE
NC score	0.051146 (rank : 122)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

MYOF_HUMAN
NC score	0.050253 (rank : 123)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

DOC2G_MOUSE
NC score	0.050114 (rank : 124)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

PA24A_MOUSE
NC score	0.047565 (rank : 125)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

DMD_HUMAN
NC score	0.046980 (rank : 126)	θ value	0.279714 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

CEP68_HUMAN
NC score	0.045611 (rank : 127)	θ value	0.00298849 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	128	Shared Neighborhood Hits	10
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

DMD_MOUSE
NC score	0.042908 (rank : 128)	θ value	0.279714 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	1111	Shared Neighborhood Hits	42
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

PA24A_HUMAN
NC score	0.041898 (rank : 129)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

NU214_HUMAN
NC score	0.040247 (rank : 130)	θ value	0.163984 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	657	Shared Neighborhood Hits	20
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

UTRO_HUMAN
NC score	0.038803 (rank : 131)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	960	Shared Neighborhood Hits	37
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

TGON2_HUMAN
NC score	0.037723 (rank : 132)	θ value	0.0736092 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

OTOF_MOUSE
NC score	0.036200 (rank : 133)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	196	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

MAGE1_HUMAN
NC score	0.028142 (rank : 134)	θ value	0.47712 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	1389	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP1B_HUMAN
NC score	0.028009 (rank : 135)	θ value	0.163984 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	903	Shared Neighborhood Hits	28
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MAP1B_MOUSE
NC score	0.027426 (rank : 136)	θ value	0.0961366 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	977	Shared Neighborhood Hits	22
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

TARA_HUMAN
NC score	0.026980 (rank : 137)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	1626	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MORN3_HUMAN
NC score	0.026314 (rank : 138)	θ value	0.365318 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

KI67_HUMAN
NC score	0.022392 (rank : 139)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	581	Shared Neighborhood Hits	17
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

LEUK_MOUSE
NC score	0.018296 (rank : 140)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	147	Shared Neighborhood Hits	12
SwissProt Accessions	P15702	Gene names	Spn
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Ly- 48) (B cell differentiation antigen LP-3) (CD43 antigen).

NFH_MOUSE
NC score	0.018094 (rank : 141)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	2247	Shared Neighborhood Hits	37
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

GRIN1_HUMAN
NC score	0.017550 (rank : 142)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	681	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SYT13_HUMAN
NC score	0.016039 (rank : 143)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

FILA_HUMAN
NC score	0.015154 (rank : 144)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	685	Shared Neighborhood Hits	22
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SOX6_MOUSE
NC score	0.014873 (rank : 145)	θ value	0.21417 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

DNS2A_HUMAN
NC score	0.012888 (rank : 146)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O00115, O43910	Gene names	DNASE2, DNASE2A, DNL2
Domain Architecture
Description	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2).

DACT1_MOUSE
NC score	0.012548 (rank : 147)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

PALM_MOUSE
NC score	0.012229 (rank : 148)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

SYT13_MOUSE
NC score	0.011698 (rank : 149)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SOX6_HUMAN
NC score	0.010542 (rank : 150)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	332	Shared Neighborhood Hits	6
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

PF21B_MOUSE
NC score	0.009071 (rank : 151)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	278	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

MAGB6_HUMAN
NC score	0.008995 (rank : 152)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

ERCC6_HUMAN
NC score	0.008803 (rank : 153)	θ value	0.365318 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	247	Shared Neighborhood Hits	9
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

FBX46_MOUSE
NC score	0.008326 (rank : 154)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

CSPG5_MOUSE
NC score	0.007815 (rank : 155)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	211	Shared Neighborhood Hits	6
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

RFIP5_MOUSE
NC score	0.006879 (rank : 156)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	126	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

IGHA1_HUMAN
NC score	0.005028 (rank : 157)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	P01876	Gene names	IGHA1
Domain Architecture
Description	Ig alpha-1 chain C region.

STRN3_HUMAN
NC score	0.004753 (rank : 158)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q13033, Q9NRA5	Gene names	STRN3, GS2NA, SG2NA
Domain Architecture
Description	Striatin-3 (Cell-cycle autoantigen SG2NA) (S/G2 antigen).

RECQ4_HUMAN
NC score	0.004127 (rank : 159)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

AMOL1_MOUSE
NC score	0.003449 (rank : 160)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

FZD6_MOUSE
NC score	0.002977 (rank : 161)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

E2AK3_HUMAN
NC score	0.000698 (rank : 162)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	859	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

PTPRF_HUMAN
NC score	-0.001965 (rank : 163)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	489	Shared Neighborhood Hits	4
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

E2AK3_MOUSE
NC score	-0.002044 (rank : 164)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	851	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

SUHW4_MOUSE
NC score	-0.002227 (rank : 165)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	737	Shared Neighborhood Hits	5
SwissProt Accessions	Q68FE8, Q3T9B1, Q8BI82	Gene names	Suhw4
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

SSPO_MOUSE
NC score	-0.002725 (rank : 166)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	800	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TITIN_HUMAN
NC score	-0.002803 (rank : 167)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	2923	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MTR1L_HUMAN
NC score	-0.004935 (rank : 168)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	1180	Shared Neighborhood Hits	8
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

OXSR1_HUMAN
NC score	-0.006219 (rank : 169)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).