Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : K1333_MOUSE

For an explanation of this page, click here

K1333_MOUSE
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

K1333_HUMAN
θ value	0 (rank : 1)	NC score	0.990227 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	50	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

K1333_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PHF7_HUMAN
θ value	3.4653e-68 (rank : 3)	NC score	0.880752 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

PHF7_MOUSE
θ value	1.31681e-67 (rank : 4)	NC score	0.891432 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DAG9, Q6PG81	Gene names	Phf7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

PHF6_MOUSE
θ value	8.10077e-17 (rank : 5)	NC score	0.644002 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	39	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D4J7, Q80T86, Q8BYT8, Q8C1B5	Gene names	Phf6, Kiaa1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6.

PHF6_HUMAN
θ value	1.80466e-16 (rank : 6)	NC score	0.647647 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWS0, Q96JK3, Q9BRU0	Gene names	PHF6, KIAA1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6 (PHD-like zinc finger protein).

PHF11_HUMAN
θ value	3.29651e-10 (rank : 7)	NC score	0.623407 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	42	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

MLL4_HUMAN
θ value	7.34386e-10 (rank : 8)	NC score	0.323191 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	722	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

HRX_HUMAN
θ value	2.13673e-09 (rank : 9)	NC score	0.316996 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

TCF20_HUMAN
θ value	4.0297e-08 (rank : 10)	NC score	0.355483 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	323	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TCF20_MOUSE
θ value	1.99992e-07 (rank : 11)	NC score	0.336054 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	396	Shared Neighborhood Hits	29
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

MLL3_HUMAN
θ value	2.88788e-06 (rank : 12)	NC score	0.233839 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	1644	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	2.88788e-06 (rank : 13)	NC score	0.246861 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	1399	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

RAI1_HUMAN
θ value	3.77169e-06 (rank : 14)	NC score	0.346815 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	360	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RAI1_MOUSE
θ value	1.43324e-05 (rank : 15)	NC score	0.340988 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	344	Shared Neighborhood Hits	31
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

MLL2_HUMAN
θ value	7.1131e-05 (rank : 16)	NC score	0.212806 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	1788	Shared Neighborhood Hits	35
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

K0317_HUMAN
θ value	0.00020696 (rank : 17)	NC score	0.139063 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	0.00020696 (rank : 18)	NC score	0.139132 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

JADE1_HUMAN
θ value	0.00175202 (rank : 19)	NC score	0.213233 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	140	Shared Neighborhood Hits	35
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

JADE1_MOUSE
θ value	0.00175202 (rank : 20)	NC score	0.212953 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

NEDD4_HUMAN
θ value	0.00298849 (rank : 21)	NC score	0.095465 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

JADE3_MOUSE
θ value	0.0113563 (rank : 22)	NC score	0.191790 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	174	Shared Neighborhood Hits	35
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

UBE3C_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.110691 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

JADE2_HUMAN
θ value	0.0252991 (rank : 24)	NC score	0.185642 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	199	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

JADE3_HUMAN
θ value	0.0330416 (rank : 25)	NC score	0.189627 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

UBE3C_MOUSE
θ value	0.0736092 (rank : 26)	NC score	0.105982 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

NEDD4_MOUSE
θ value	0.125558 (rank : 27)	NC score	0.078139 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	212	Shared Neighborhood Hits	12
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

JADE2_MOUSE
θ value	0.163984 (rank : 28)	NC score	0.166983 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	560	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

SMUF1_HUMAN
θ value	0.21417 (rank : 29)	NC score	0.080568 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

MSMB_HUMAN
θ value	0.279714 (rank : 30)	NC score	0.071634 (rank : 56)
Query Neighborhood Hits	53	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	P08118, P11999, Q13125, Q9UC59	Gene names	MSMB, PRSP
Domain Architecture
Description	Beta-microseminoprotein precursor (Prostate secreted seminal plasma protein) (Prostate secretory protein PSP94) (PSP-94) (Seminal plasma beta-inhibin) (Immunoglobulin-binding factor) (IGBF) (PN44).

BRPF3_HUMAN
θ value	0.47712 (rank : 31)	NC score	0.143599 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	217	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

HECD1_HUMAN
θ value	0.62314 (rank : 32)	NC score	0.066018 (rank : 60)
Query Neighborhood Hits	53	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

SMUF1_MOUSE
θ value	0.813845 (rank : 33)	NC score	0.077950 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

TRIPC_HUMAN
θ value	1.06291 (rank : 34)	NC score	0.079001 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	319	Shared Neighborhood Hits	15
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

PF21A_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.077213 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	303	Shared Neighborhood Hits	23
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PF21A_MOUSE
θ value	1.38821 (rank : 36)	NC score	0.081006 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

BRPF1_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.138491 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	259	Shared Neighborhood Hits	33
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

JHD3B_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.104405 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	128	Shared Neighborhood Hits	30
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

ZN662_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.002376 (rank : 103)
Query Neighborhood Hits	53	Target Neighborhood Hits	738	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZS27, Q6ZNF8, Q6ZQW8	Gene names	ZNF662
Domain Architecture	No domain graphic available
Description	Zinc finger protein 662.

BRD1_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.140027 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	O95696	Gene names	BRD1, BRL, BRPF2
Domain Architecture
Description	Bromodomain-containing protein 1 (BR140-like protein).

JHD3B_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.100042 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

SMUF2_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.074991 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ZN600_HUMAN
θ value	4.03905 (rank : 43)	NC score	-0.000628 (rank : 104)
Query Neighborhood Hits	53	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZNG1, Q6MZR0	Gene names	ZNF600
Domain Architecture	No domain graphic available
Description	Zinc finger protein 600.

DICER_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.011705 (rank : 100)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

TRI63_HUMAN
θ value	5.27518 (rank : 45)	NC score	0.005610 (rank : 101)
Query Neighborhood Hits	53	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

CHD3_HUMAN
θ value	6.88961 (rank : 46)	NC score	0.037098 (rank : 99)
Query Neighborhood Hits	53	Target Neighborhood Hits	397	Shared Neighborhood Hits	26
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD5_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.038753 (rank : 98)
Query Neighborhood Hits	53	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

JHD3A_MOUSE
θ value	6.88961 (rank : 48)	NC score	0.089064 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BW72, Q3UKM5, Q3UM81, Q3UWV2, Q6ZQ72, Q8K137	Gene names	Jmjd2a, Jhdm3a, Jmjd2, Kiaa0677
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

JHD3A_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.088723 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	78	Shared Neighborhood Hits	25
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

KR101_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.004172 (rank : 102)
Query Neighborhood Hits	53	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

NSD1_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.102896 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	427	Shared Neighborhood Hits	29
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
θ value	8.99809 (rank : 52)	NC score	0.105395 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	472	Shared Neighborhood Hits	30
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

ZN699_HUMAN
θ value	8.99809 (rank : 53)	NC score	-0.000985 (rank : 105)
Query Neighborhood Hits	53	Target Neighborhood Hits	773	Shared Neighborhood Hits	6
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).

AF10_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.094949 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

AF10_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.094916 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	182	Shared Neighborhood Hits	27
SwissProt Accessions	O54826	Gene names	Mllt10, Af10
Domain Architecture
Description	Protein AF-10.

AF17_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.103252 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	230	Shared Neighborhood Hits	27
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

AIRE_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.053309 (rank : 95)
Query Neighborhood Hits	53	Target Neighborhood Hits	196	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

DPF1_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.058954 (rank : 84)
Query Neighborhood Hits	53	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

DPF1_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.057723 (rank : 85)
Query Neighborhood Hits	53	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QX66, Q9QX65, Q9QYA4	Gene names	Dpf1, Neud4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

EDD1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.054853 (rank : 94)
Query Neighborhood Hits	53	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.055631 (rank : 91)
Query Neighborhood Hits	53	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EZH1_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.064619 (rank : 68)
Query Neighborhood Hits	53	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.064535 (rank : 69)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.065221 (rank : 63)
Query Neighborhood Hits	53	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.064800 (rank : 65)
Query Neighborhood Hits	53	Target Neighborhood Hits	86	Shared Neighborhood Hits	7
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

HECD2_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.067628 (rank : 58)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.062425 (rank : 80)
Query Neighborhood Hits	53	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.050047 (rank : 97)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	11
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HUWE1_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.064511 (rank : 70)
Query Neighborhood Hits	53	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.065846 (rank : 61)
Query Neighborhood Hits	53	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITCH_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.064070 (rank : 73)
Query Neighborhood Hits	53	Target Neighborhood Hits	162	Shared Neighborhood Hits	12
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.064765 (rank : 66)
Query Neighborhood Hits	53	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

JHD3C_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.076902 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

JHD3C_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.081743 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	84	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VCD7, Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1	Gene names	Jmjd2c, Jhdm3c, Kiaa0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C).

MTF2_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.064384 (rank : 71)
Query Neighborhood Hits	53	Target Neighborhood Hits	119	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y483, Q9UES9, Q9UP40	Gene names	MTF2
Domain Architecture
Description	Metal-response element-binding transcription factor 2 (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MTF2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.063894 (rank : 75)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	20
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MYST3_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.057581 (rank : 87)
Query Neighborhood Hits	53	Target Neighborhood Hits	772	Shared Neighborhood Hits	24
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MYST3_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.056909 (rank : 88)
Query Neighborhood Hits	53	Target Neighborhood Hits	688	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

MYST4_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.064183 (rank : 72)
Query Neighborhood Hits	53	Target Neighborhood Hits	671	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MYST4_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.066436 (rank : 59)
Query Neighborhood Hits	53	Target Neighborhood Hits	416	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

NED4L_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.065131 (rank : 64)
Query Neighborhood Hits	53	Target Neighborhood Hits	238	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.065222 (rank : 62)
Query Neighborhood Hits	53	Target Neighborhood Hits	231	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PHF10_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.079613 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	151	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

PHF10_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.078916 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

PHF14_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.108856 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	447	Shared Neighborhood Hits	31
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PHF14_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.111145 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

PHF1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.060605 (rank : 81)
Query Neighborhood Hits	53	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	O43189, O60929, Q96KM7	Gene names	PHF1
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1).

PHF1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.060486 (rank : 82)
Query Neighborhood Hits	53	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1B8, O54808	Gene names	Phf1, Tctex-3, Tctex3
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1) (T-complex testis-expressed 3) (Polycomblike 1) (mPCl1).

REQU_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.056225 (rank : 90)
Query Neighborhood Hits	53	Target Neighborhood Hits	523	Shared Neighborhood Hits	23
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

REQU_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.055222 (rank : 93)
Query Neighborhood Hits	53	Target Neighborhood Hits	519	Shared Neighborhood Hits	23
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

SET1A_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.093615 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	690	Shared Neighborhood Hits	11
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SETB2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.051467 (rank : 96)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

SETD2_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.076740 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	412	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SETD8_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.074954 (rank : 55)
Query Neighborhood Hits	53	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

SETD8_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.071197 (rank : 57)
Query Neighborhood Hits	53	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

SUV91_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.056543 (rank : 89)
Query Neighborhood Hits	53	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

SUV91_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.055561 (rank : 92)
Query Neighborhood Hits	53	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

SUV92_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.059344 (rank : 83)
Query Neighborhood Hits	53	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

SUV92_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.057719 (rank : 86)
Query Neighborhood Hits	53	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

UBE3A_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.064664 (rank : 67)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.063358 (rank : 77)
Query Neighborhood Hits	53	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

WWP1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.062959 (rank : 79)
Query Neighborhood Hits	53	Target Neighborhood Hits	262	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.063216 (rank : 78)
Query Neighborhood Hits	53	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.063777 (rank : 76)
Query Neighborhood Hits	53	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.063931 (rank : 74)
Query Neighborhood Hits	53	Target Neighborhood Hits	118	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

K1333_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	53	Target Neighborhood Hits	53	Shared Neighborhood Hits	53
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

K1333_HUMAN
NC score	0.990227 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	53	Target Neighborhood Hits	50	Shared Neighborhood Hits	34
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PHF7_MOUSE
NC score	0.891432 (rank : 3)	θ value	1.31681e-67 (rank : 4)
Query Neighborhood Hits	53	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DAG9, Q6PG81	Gene names	Phf7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

PHF7_HUMAN
NC score	0.880752 (rank : 4)	θ value	3.4653e-68 (rank : 3)
Query Neighborhood Hits	53	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

PHF6_HUMAN
NC score	0.647647 (rank : 5)	θ value	1.80466e-16 (rank : 6)
Query Neighborhood Hits	53	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWS0, Q96JK3, Q9BRU0	Gene names	PHF6, KIAA1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6 (PHD-like zinc finger protein).

PHF6_MOUSE
NC score	0.644002 (rank : 6)	θ value	8.10077e-17 (rank : 5)
Query Neighborhood Hits	53	Target Neighborhood Hits	39	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D4J7, Q80T86, Q8BYT8, Q8C1B5	Gene names	Phf6, Kiaa1823
Domain Architecture	No domain graphic available
Description	PHD finger protein 6.

PHF11_HUMAN
NC score	0.623407 (rank : 7)	θ value	3.29651e-10 (rank : 7)
Query Neighborhood Hits	53	Target Neighborhood Hits	42	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UIL8, Q9Y5A2	Gene names	PHF11, BCAP
Domain Architecture	No domain graphic available
Description	PHD finger protein 11 (BRCA1 C-terminus-associated protein) (NY-REN-34 antigen).

TCF20_HUMAN
NC score	0.355483 (rank : 8)	θ value	4.0297e-08 (rank : 10)
Query Neighborhood Hits	53	Target Neighborhood Hits	323	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

RAI1_HUMAN
NC score	0.346815 (rank : 9)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	53	Target Neighborhood Hits	360	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RAI1_MOUSE
NC score	0.340988 (rank : 10)	θ value	1.43324e-05 (rank : 15)
Query Neighborhood Hits	53	Target Neighborhood Hits	344	Shared Neighborhood Hits	31
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

TCF20_MOUSE
NC score	0.336054 (rank : 11)	θ value	1.99992e-07 (rank : 11)
Query Neighborhood Hits	53	Target Neighborhood Hits	396	Shared Neighborhood Hits	29
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

MLL4_HUMAN
NC score	0.323191 (rank : 12)	θ value	7.34386e-10 (rank : 8)
Query Neighborhood Hits	53	Target Neighborhood Hits	722	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

HRX_HUMAN
NC score	0.316996 (rank : 13)	θ value	2.13673e-09 (rank : 9)
Query Neighborhood Hits	53	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MLL3_MOUSE
NC score	0.246861 (rank : 14)	θ value	2.88788e-06 (rank : 13)
Query Neighborhood Hits	53	Target Neighborhood Hits	1399	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MLL3_HUMAN
NC score	0.233839 (rank : 15)	θ value	2.88788e-06 (rank : 12)
Query Neighborhood Hits	53	Target Neighborhood Hits	1644	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

JADE1_HUMAN
NC score	0.213233 (rank : 16)	θ value	0.00175202 (rank : 19)
Query Neighborhood Hits	53	Target Neighborhood Hits	140	Shared Neighborhood Hits	35
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

JADE1_MOUSE
NC score	0.212953 (rank : 17)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	53	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

MLL2_HUMAN
NC score	0.212806 (rank : 18)	θ value	7.1131e-05 (rank : 16)
Query Neighborhood Hits	53	Target Neighborhood Hits	1788	Shared Neighborhood Hits	35
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

JADE3_MOUSE
NC score	0.191790 (rank : 19)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	53	Target Neighborhood Hits	174	Shared Neighborhood Hits	35
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

JADE3_HUMAN
NC score	0.189627 (rank : 20)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	53	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

JADE2_HUMAN
NC score	0.185642 (rank : 21)	θ value	0.0252991 (rank : 24)
Query Neighborhood Hits	53	Target Neighborhood Hits	199	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

JADE2_MOUSE
NC score	0.166983 (rank : 22)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	53	Target Neighborhood Hits	560	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

BRPF3_HUMAN
NC score	0.143599 (rank : 23)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	53	Target Neighborhood Hits	217	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

BRD1_HUMAN
NC score	0.140027 (rank : 24)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	53	Target Neighborhood Hits	188	Shared Neighborhood Hits	32
SwissProt Accessions	O95696	Gene names	BRD1, BRL, BRPF2
Domain Architecture
Description	Bromodomain-containing protein 1 (BR140-like protein).

K0317_MOUSE
NC score	0.139132 (rank : 25)	θ value	0.00020696 (rank : 18)
Query Neighborhood Hits	53	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.139063 (rank : 26)	θ value	0.00020696 (rank : 17)
Query Neighborhood Hits	53	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

BRPF1_HUMAN
NC score	0.138491 (rank : 27)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	53	Target Neighborhood Hits	259	Shared Neighborhood Hits	33
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

PHF14_MOUSE
NC score	0.111145 (rank : 28)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	53	Target Neighborhood Hits	342	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

UBE3C_HUMAN
NC score	0.110691 (rank : 29)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	53	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

PHF14_HUMAN
NC score	0.108856 (rank : 30)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	53	Target Neighborhood Hits	447	Shared Neighborhood Hits	31
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

UBE3C_MOUSE
NC score	0.105982 (rank : 31)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	53	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

NSD1_MOUSE
NC score	0.105395 (rank : 32)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	53	Target Neighborhood Hits	472	Shared Neighborhood Hits	30
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

JHD3B_HUMAN
NC score	0.104405 (rank : 33)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	53	Target Neighborhood Hits	128	Shared Neighborhood Hits	30
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

AF17_HUMAN
NC score	0.103252 (rank : 34)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	53	Target Neighborhood Hits	230	Shared Neighborhood Hits	27
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

NSD1_HUMAN
NC score	0.102896 (rank : 35)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	53	Target Neighborhood Hits	427	Shared Neighborhood Hits	29
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

JHD3B_MOUSE
NC score	0.100042 (rank : 36)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	53	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

NEDD4_HUMAN
NC score	0.095465 (rank : 37)	θ value	0.00298849 (rank : 21)
Query Neighborhood Hits	53	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

AF10_HUMAN
NC score	0.094949 (rank : 38)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	53	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

AF10_MOUSE
NC score	0.094916 (rank : 39)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	53	Target Neighborhood Hits	182	Shared Neighborhood Hits	27
SwissProt Accessions	O54826	Gene names	Mllt10, Af10
Domain Architecture
Description	Protein AF-10.

SET1A_HUMAN
NC score	0.093615 (rank : 40)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	53	Target Neighborhood Hits	690	Shared Neighborhood Hits	11
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

JHD3A_MOUSE
NC score	0.089064 (rank : 41)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	53	Target Neighborhood Hits	85	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BW72, Q3UKM5, Q3UM81, Q3UWV2, Q6ZQ72, Q8K137	Gene names	Jmjd2a, Jhdm3a, Jmjd2, Kiaa0677
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

JHD3A_HUMAN
NC score	0.088723 (rank : 42)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	53	Target Neighborhood Hits	78	Shared Neighborhood Hits	25
SwissProt Accessions	O75164, Q5VVB1	Gene names	JMJD2A, JHDM3A, JMJD2, KIAA0677
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3A (EC 1.14.11.-) (Jumonji domain-containing protein 2A).

JHD3C_MOUSE
NC score	0.081743 (rank : 43)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	53	Target Neighborhood Hits	84	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VCD7, Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1	Gene names	Jmjd2c, Jhdm3c, Kiaa0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C).

PF21A_MOUSE
NC score	0.081006 (rank : 44)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	53	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

SMUF1_HUMAN
NC score	0.080568 (rank : 45)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	53	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

PHF10_HUMAN
NC score	0.079613 (rank : 46)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	53	Target Neighborhood Hits	151	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

TRIPC_HUMAN
NC score	0.079001 (rank : 47)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	53	Target Neighborhood Hits	319	Shared Neighborhood Hits	15
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

PHF10_MOUSE
NC score	0.078916 (rank : 48)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	53	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

NEDD4_MOUSE
NC score	0.078139 (rank : 49)	θ value	0.125558 (rank : 27)
Query Neighborhood Hits	53	Target Neighborhood Hits	212	Shared Neighborhood Hits	12
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF1_MOUSE
NC score	0.077950 (rank : 50)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	53	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

PF21A_HUMAN
NC score	0.077213 (rank : 51)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	53	Target Neighborhood Hits	303	Shared Neighborhood Hits	23
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

JHD3C_HUMAN
NC score	0.076902 (rank : 52)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	53	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

SETD2_HUMAN
NC score	0.076740 (rank : 53)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	53	Target Neighborhood Hits	412	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SMUF2_HUMAN
NC score	0.074991 (rank : 54)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	53	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SETD8_HUMAN
NC score	0.074954 (rank : 55)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	53	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

MSMB_HUMAN
NC score	0.071634 (rank : 56)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	53	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	P08118, P11999, Q13125, Q9UC59	Gene names	MSMB, PRSP
Domain Architecture
Description	Beta-microseminoprotein precursor (Prostate secreted seminal plasma protein) (Prostate secretory protein PSP94) (PSP-94) (Seminal plasma beta-inhibin) (Immunoglobulin-binding factor) (IGBF) (PN44).

SETD8_MOUSE
NC score	0.071197 (rank : 57)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	53	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

HECD2_HUMAN
NC score	0.067628 (rank : 58)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	53	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

MYST4_MOUSE
NC score	0.066436 (rank : 59)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	53	Target Neighborhood Hits	416	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

HECD1_HUMAN
NC score	0.066018 (rank : 60)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	53	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HUWE1_MOUSE
NC score	0.065846 (rank : 61)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	53	Target Neighborhood Hits	406	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NED4L_MOUSE
NC score	0.065222 (rank : 62)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	53	Target Neighborhood Hits	231	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

EZH2_HUMAN
NC score	0.065221 (rank : 63)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	53	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

NED4L_HUMAN
NC score	0.065131 (rank : 64)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	53	Target Neighborhood Hits	238	Shared Neighborhood Hits	12
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

EZH2_MOUSE
NC score	0.064800 (rank : 65)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	53	Target Neighborhood Hits	86	Shared Neighborhood Hits	7
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

ITCH_MOUSE
NC score	0.064765 (rank : 66)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	53	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

UBE3A_HUMAN
NC score	0.064664 (rank : 67)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	53	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

EZH1_HUMAN
NC score	0.064619 (rank : 68)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	53	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

EZH1_MOUSE
NC score	0.064535 (rank : 69)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

HUWE1_HUMAN
NC score	0.064511 (rank : 70)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	53	Target Neighborhood Hits	443	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

MTF2_HUMAN
NC score	0.064384 (rank : 71)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	53	Target Neighborhood Hits	119	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y483, Q9UES9, Q9UP40	Gene names	MTF2
Domain Architecture
Description	Metal-response element-binding transcription factor 2 (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MYST4_HUMAN
NC score	0.064183 (rank : 72)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	53	Target Neighborhood Hits	671	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

ITCH_HUMAN
NC score	0.064070 (rank : 73)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	53	Target Neighborhood Hits	162	Shared Neighborhood Hits	12
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP2_MOUSE
NC score	0.063931 (rank : 74)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	53	Target Neighborhood Hits	118	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

MTF2_MOUSE
NC score	0.063894 (rank : 75)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	20
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

WWP2_HUMAN
NC score	0.063777 (rank : 76)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	53	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

UBE3A_MOUSE
NC score	0.063358 (rank : 77)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	53	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

WWP1_MOUSE
NC score	0.063216 (rank : 78)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	53	Target Neighborhood Hits	138	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP1_HUMAN
NC score	0.062959 (rank : 79)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	53	Target Neighborhood Hits	262	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

HECD2_MOUSE
NC score	0.062425 (rank : 80)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	53	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

PHF1_HUMAN
NC score	0.060605 (rank : 81)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	53	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	O43189, O60929, Q96KM7	Gene names	PHF1
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1).

PHF1_MOUSE
NC score	0.060486 (rank : 82)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	53	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z1B8, O54808	Gene names	Phf1, Tctex-3, Tctex3
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1) (T-complex testis-expressed 3) (Polycomblike 1) (mPCl1).

SUV92_HUMAN
NC score	0.059344 (rank : 83)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	53	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H5I1	Gene names	SUV39H2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

DPF1_HUMAN
NC score	0.058954 (rank : 84)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	53	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

DPF1_MOUSE
NC score	0.057723 (rank : 85)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	53	Target Neighborhood Hits	491	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QX66, Q9QX65, Q9QYA4	Gene names	Dpf1, Neud4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

SUV92_MOUSE
NC score	0.057719 (rank : 86)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	53	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQQ0, Q9CUK3, Q9JLP7	Gene names	Suv39h2
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 2 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2).

MYST3_HUMAN
NC score	0.057581 (rank : 87)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	53	Target Neighborhood Hits	772	Shared Neighborhood Hits	24
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MYST3_MOUSE
NC score	0.056909 (rank : 88)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	53	Target Neighborhood Hits	688	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

SUV91_HUMAN
NC score	0.056543 (rank : 89)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	53	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	O43463, Q53G60, Q6FHK6	Gene names	SUV39H1, SUV39H
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1).

REQU_HUMAN
NC score	0.056225 (rank : 90)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	53	Target Neighborhood Hits	523	Shared Neighborhood Hits	23
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

EDD1_MOUSE
NC score	0.055631 (rank : 91)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	53	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

SUV91_MOUSE
NC score	0.055561 (rank : 92)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	53	Target Neighborhood Hits	69	Shared Neighborhood Hits	7
SwissProt Accessions	O54864, Q9JLC7, Q9JLP8	Gene names	Suv39h1, Suv39h
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 1 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1) (Position-effect variegation 3-9 homolog).

REQU_MOUSE
NC score	0.055222 (rank : 93)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	53	Target Neighborhood Hits	519	Shared Neighborhood Hits	23
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

EDD1_HUMAN
NC score	0.054853 (rank : 94)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	53	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

AIRE_MOUSE
NC score	0.053309 (rank : 95)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	53	Target Neighborhood Hits	196	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

SETB2_HUMAN
NC score	0.051467 (rank : 96)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T68, Q86UD6, Q96AI6	Gene names	SETDB2, CLLD8
Domain Architecture
Description	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific (EC 2.1.1.43) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (SET domain bifurcated 2) (Chronic lymphocytic leukemia deletion region gene 8 protein).

HERC3_HUMAN
NC score	0.050047 (rank : 97)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	53	Target Neighborhood Hits	62	Shared Neighborhood Hits	11
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

CHD5_HUMAN
NC score	0.038753 (rank : 98)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	53	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CHD3_HUMAN
NC score	0.037098 (rank : 99)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	53	Target Neighborhood Hits	397	Shared Neighborhood Hits	26
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

DICER_HUMAN
NC score	0.011705 (rank : 100)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	53	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

TRI63_HUMAN
NC score	0.005610 (rank : 101)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	53	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

KR101_HUMAN
NC score	0.004172 (rank : 102)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	53	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

ZN662_HUMAN
NC score	0.002376 (rank : 103)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	53	Target Neighborhood Hits	738	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZS27, Q6ZNF8, Q6ZQW8	Gene names	ZNF662
Domain Architecture	No domain graphic available
Description	Zinc finger protein 662.

ZN600_HUMAN
NC score	-0.000628 (rank : 104)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	53	Target Neighborhood Hits	774	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZNG1, Q6MZR0	Gene names	ZNF600
Domain Architecture	No domain graphic available
Description	Zinc finger protein 600.

ZN699_HUMAN
NC score	-0.000985 (rank : 105)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	53	Target Neighborhood Hits	773	Shared Neighborhood Hits	6
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).