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Network neighborhood for query Sequence : TOLIP_HUMAN

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TOLIP_HUMAN
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOLIP_HUMAN
θ value	3.89193e-128 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

TOLIP_MOUSE
θ value	3.52827e-121 (rank : 2)	NC score	0.994504 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

NED4L_MOUSE
θ value	0.00102713 (rank : 3)	NC score	0.122959 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

ITSN2_HUMAN
θ value	0.00869519 (rank : 4)	NC score	0.080955 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	1173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CUED1_HUMAN
θ value	0.0113563 (rank : 5)	NC score	0.224534 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

CUED1_MOUSE
θ value	0.0113563 (rank : 6)	NC score	0.225295 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

ITSN2_MOUSE
θ value	0.0193708 (rank : 7)	NC score	0.076151 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	1371	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITCH_HUMAN
θ value	0.163984 (rank : 8)	NC score	0.092315 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NED4L_HUMAN
θ value	0.163984 (rank : 9)	NC score	0.106785 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

RFIP1_MOUSE
θ value	0.21417 (rank : 10)	NC score	0.092913 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

FA62A_MOUSE
θ value	0.279714 (rank : 11)	NC score	0.125518 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASA1_HUMAN
θ value	0.365318 (rank : 12)	NC score	0.052427 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PA24F_MOUSE
θ value	0.47712 (rank : 13)	NC score	0.047924 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

SYT9_HUMAN
θ value	0.47712 (rank : 14)	NC score	0.062329 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	0.47712 (rank : 15)	NC score	0.062421 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

NEDD4_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.102635 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

FA62A_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.115785 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

NEDD4_MOUSE
θ value	1.38821 (rank : 18)	NC score	0.099845 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	212	Shared Neighborhood Hits	15
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

PAR14_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.024278 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

ITCH_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.077660 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

HECD2_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.052357 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.052462 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HUWE1_HUMAN
θ value	θ > 10 (rank : 23)	NC score	0.054265 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	443	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.054366 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.057873 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.057940 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

RASL2_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.050435 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SMUF1_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.064384 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.064174 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.065306 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

UBE3A_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.051653 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.051197 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.051868 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.051858 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWP1_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.064856 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.064334 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.062819 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.063005 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

TOLIP_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.89193e-128 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

TOLIP_MOUSE
NC score	0.994504 (rank : 2)	θ value	3.52827e-121 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

CUED1_MOUSE
NC score	0.225295 (rank : 3)	θ value	0.0113563 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

CUED1_HUMAN
NC score	0.224534 (rank : 4)	θ value	0.0113563 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

FA62A_MOUSE
NC score	0.125518 (rank : 5)	θ value	0.279714 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

NED4L_MOUSE
NC score	0.122959 (rank : 6)	θ value	0.00102713 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

FA62A_HUMAN
NC score	0.115785 (rank : 7)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

NED4L_HUMAN
NC score	0.106785 (rank : 8)	θ value	0.163984 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	238	Shared Neighborhood Hits	15
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
NC score	0.102635 (rank : 9)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
NC score	0.099845 (rank : 10)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	212	Shared Neighborhood Hits	15
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

RFIP1_MOUSE
NC score	0.092913 (rank : 11)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ITCH_HUMAN
NC score	0.092315 (rank : 12)	θ value	0.163984 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITSN2_HUMAN
NC score	0.080955 (rank : 13)	θ value	0.00869519 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	1173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITCH_MOUSE
NC score	0.077660 (rank : 14)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITSN2_MOUSE
NC score	0.076151 (rank : 15)	θ value	0.0193708 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	1371	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SMUF2_HUMAN
NC score	0.065306 (rank : 16)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

WWP1_HUMAN
NC score	0.064856 (rank : 17)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

SMUF1_HUMAN
NC score	0.064384 (rank : 18)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

WWP1_MOUSE
NC score	0.064334 (rank : 19)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

SMUF1_MOUSE
NC score	0.064174 (rank : 20)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

WWP2_MOUSE
NC score	0.063005 (rank : 21)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.062819 (rank : 22)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

SYT9_MOUSE
NC score	0.062421 (rank : 23)	θ value	0.47712 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

SYT9_HUMAN
NC score	0.062329 (rank : 24)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

K0317_MOUSE
NC score	0.057940 (rank : 25)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.057873 (rank : 26)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_MOUSE
NC score	0.054366 (rank : 27)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.054265 (rank : 28)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	443	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.052462 (rank : 29)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

RASA1_HUMAN
NC score	0.052427 (rank : 30)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

HECD2_HUMAN
NC score	0.052357 (rank : 31)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3C_HUMAN
NC score	0.051868 (rank : 32)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.051858 (rank : 33)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_HUMAN
NC score	0.051653 (rank : 34)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.051197 (rank : 35)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

RASL2_HUMAN
NC score	0.050435 (rank : 36)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

PA24F_MOUSE
NC score	0.047924 (rank : 37)	θ value	0.47712 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PAR14_MOUSE
NC score	0.024278 (rank : 38)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).