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Network neighborhood for query Sequence : UN13D_HUMAN

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UN13D_HUMAN
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UN13D_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

BAIP3_HUMAN
θ value	9.85132e-148 (rank : 2)	NC score	0.937723 (rank : 2)
Query Neighborhood Hits	117	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
θ value	2.35023e-141 (rank : 3)	NC score	0.936288 (rank : 3)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

UN13B_HUMAN
θ value	1.85889e-29 (rank : 4)	NC score	0.598864 (rank : 12)
Query Neighborhood Hits	117	Target Neighborhood Hits	217	Shared Neighborhood Hits	88
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
θ value	7.0802e-21 (rank : 5)	NC score	0.578258 (rank : 24)
Query Neighborhood Hits	117	Target Neighborhood Hits	285	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_MOUSE
θ value	9.56915e-18 (rank : 6)	NC score	0.574829 (rank : 28)
Query Neighborhood Hits	117	Target Neighborhood Hits	210	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT2_MOUSE
θ value	2.52405e-10 (rank : 7)	NC score	0.597529 (rank : 14)
Query Neighborhood Hits	117	Target Neighborhood Hits	143	Shared Neighborhood Hits	98
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT5_HUMAN
θ value	3.29651e-10 (rank : 8)	NC score	0.607940 (rank : 6)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	98
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT2_HUMAN
θ value	7.34386e-10 (rank : 9)	NC score	0.596855 (rank : 17)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT1_HUMAN
θ value	1.25267e-09 (rank : 10)	NC score	0.603786 (rank : 7)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	1.25267e-09 (rank : 11)	NC score	0.603765 (rank : 8)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT7_MOUSE
θ value	2.13673e-09 (rank : 12)	NC score	0.608907 (rank : 5)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_HUMAN
θ value	2.79066e-09 (rank : 13)	NC score	0.608975 (rank : 4)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT6_HUMAN
θ value	6.21693e-09 (rank : 14)	NC score	0.597521 (rank : 15)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	96
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	8.11959e-09 (rank : 15)	NC score	0.597479 (rank : 16)
Query Neighborhood Hits	117	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT3_HUMAN
θ value	1.06045e-08 (rank : 16)	NC score	0.602073 (rank : 9)
Query Neighborhood Hits	117	Target Neighborhood Hits	145	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	3.08544e-08 (rank : 17)	NC score	0.600557 (rank : 11)
Query Neighborhood Hits	117	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

NED4L_HUMAN
θ value	8.97725e-08 (rank : 18)	NC score	0.322161 (rank : 70)
Query Neighborhood Hits	117	Target Neighborhood Hits	238	Shared Neighborhood Hits	94
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	8.97725e-08 (rank : 19)	NC score	0.319022 (rank : 71)
Query Neighborhood Hits	117	Target Neighborhood Hits	231	Shared Neighborhood Hits	93
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SYT10_HUMAN
θ value	8.97725e-08 (rank : 20)	NC score	0.595392 (rank : 18)
Query Neighborhood Hits	117	Target Neighborhood Hits	134	Shared Neighborhood Hits	96
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

KPCA_MOUSE
θ value	1.17247e-07 (rank : 21)	NC score	0.171345 (rank : 105)
Query Neighborhood Hits	117	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_HUMAN
θ value	1.99992e-07 (rank : 22)	NC score	0.173191 (rank : 104)
Query Neighborhood Hits	117	Target Neighborhood Hits	1070	Shared Neighborhood Hits	98
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SYT9_HUMAN
θ value	5.81887e-07 (rank : 23)	NC score	0.591089 (rank : 19)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	97
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT10_MOUSE
θ value	7.59969e-07 (rank : 24)	NC score	0.597938 (rank : 13)
Query Neighborhood Hits	117	Target Neighborhood Hits	133	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT4_MOUSE
θ value	7.59969e-07 (rank : 25)	NC score	0.576483 (rank : 25)
Query Neighborhood Hits	117	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT8_MOUSE
θ value	1.29631e-06 (rank : 26)	NC score	0.512302 (rank : 34)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	77
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

DOC2G_MOUSE
θ value	2.21117e-06 (rank : 27)	NC score	0.576066 (rank : 26)
Query Neighborhood Hits	117	Target Neighborhood Hits	125	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT5_MOUSE
θ value	2.21117e-06 (rank : 28)	NC score	0.601195 (rank : 10)
Query Neighborhood Hits	117	Target Neighborhood Hits	140	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

RASL2_HUMAN
θ value	2.88788e-06 (rank : 29)	NC score	0.498293 (rank : 37)
Query Neighborhood Hits	117	Target Neighborhood Hits	161	Shared Neighborhood Hits	96
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SYT11_HUMAN
θ value	2.88788e-06 (rank : 30)	NC score	0.568363 (rank : 31)
Query Neighborhood Hits	117	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	2.88788e-06 (rank : 31)	NC score	0.569390 (rank : 30)
Query Neighborhood Hits	117	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

PCLO_MOUSE
θ value	6.43352e-06 (rank : 32)	NC score	0.358353 (rank : 64)
Query Neighborhood Hits	117	Target Neighborhood Hits	2275	Shared Neighborhood Hits	100
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SYT4_HUMAN
θ value	1.09739e-05 (rank : 33)	NC score	0.570018 (rank : 29)
Query Neighborhood Hits	117	Target Neighborhood Hits	121	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT9_MOUSE
θ value	1.43324e-05 (rank : 34)	NC score	0.585406 (rank : 20)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

PCLO_HUMAN
θ value	1.87187e-05 (rank : 35)	NC score	0.377415 (rank : 58)
Query Neighborhood Hits	117	Target Neighborhood Hits	2046	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

KPCG_HUMAN
θ value	3.19293e-05 (rank : 36)	NC score	0.183991 (rank : 100)
Query Neighborhood Hits	117	Target Neighborhood Hits	1126	Shared Neighborhood Hits	96
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	3.19293e-05 (rank : 37)	NC score	0.183556 (rank : 101)
Query Neighborhood Hits	117	Target Neighborhood Hits	1123	Shared Neighborhood Hits	96
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

RP3A_MOUSE
θ value	4.1701e-05 (rank : 38)	NC score	0.553134 (rank : 33)
Query Neighborhood Hits	117	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

KPCB_MOUSE
θ value	5.44631e-05 (rank : 39)	NC score	0.170336 (rank : 106)
Query Neighborhood Hits	117	Target Neighborhood Hits	1117	Shared Neighborhood Hits	97
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

DOC2B_MOUSE
θ value	7.1131e-05 (rank : 40)	NC score	0.583775 (rank : 22)
Query Neighborhood Hits	117	Target Neighborhood Hits	169	Shared Neighborhood Hits	97
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RP3A_HUMAN
θ value	7.1131e-05 (rank : 41)	NC score	0.556586 (rank : 32)
Query Neighborhood Hits	117	Target Neighborhood Hits	305	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYTL1_HUMAN
θ value	0.000121331 (rank : 42)	NC score	0.486066 (rank : 39)
Query Neighborhood Hits	117	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYT12_MOUSE
θ value	0.000158464 (rank : 43)	NC score	0.510833 (rank : 35)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

DOC2B_HUMAN
θ value	0.00020696 (rank : 44)	NC score	0.585280 (rank : 21)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	97
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_HUMAN
θ value	0.000270298 (rank : 45)	NC score	0.579311 (rank : 23)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	97
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

NEDD4_HUMAN
θ value	0.000270298 (rank : 46)	NC score	0.294176 (rank : 73)
Query Neighborhood Hits	117	Target Neighborhood Hits	214	Shared Neighborhood Hits	94
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

OTOF_HUMAN
θ value	0.000270298 (rank : 47)	NC score	0.362078 (rank : 61)
Query Neighborhood Hits	117	Target Neighborhood Hits	168	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

KPCB_HUMAN
θ value	0.00035302 (rank : 48)	NC score	0.166514 (rank : 110)
Query Neighborhood Hits	117	Target Neighborhood Hits	1121	Shared Neighborhood Hits	97
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

OTOF_MOUSE
θ value	0.00035302 (rank : 49)	NC score	0.358568 (rank : 63)
Query Neighborhood Hits	117	Target Neighborhood Hits	196	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

DOC2A_MOUSE
θ value	0.000461057 (rank : 50)	NC score	0.575682 (rank : 27)
Query Neighborhood Hits	117	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

SYTL5_HUMAN
θ value	0.000461057 (rank : 51)	NC score	0.455399 (rank : 45)
Query Neighborhood Hits	117	Target Neighborhood Hits	237	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL1_MOUSE
θ value	0.000602161 (rank : 52)	NC score	0.433604 (rank : 49)
Query Neighborhood Hits	117	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

NEDD4_MOUSE
θ value	0.000786445 (rank : 53)	NC score	0.290107 (rank : 74)
Query Neighborhood Hits	117	Target Neighborhood Hits	212	Shared Neighborhood Hits	94
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SYT12_HUMAN
θ value	0.00175202 (rank : 54)	NC score	0.499320 (rank : 36)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

DYSF_MOUSE
θ value	0.00228821 (rank : 55)	NC score	0.365045 (rank : 59)
Query Neighborhood Hits	117	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

RIMS2_MOUSE
θ value	0.00509761 (rank : 56)	NC score	0.361029 (rank : 62)
Query Neighborhood Hits	117	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SYTL5_MOUSE
θ value	0.00665767 (rank : 57)	NC score	0.453158 (rank : 46)
Query Neighborhood Hits	117	Target Neighborhood Hits	154	Shared Neighborhood Hits	90
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

MYOF_HUMAN
θ value	0.0113563 (rank : 58)	NC score	0.377926 (rank : 57)
Query Neighborhood Hits	117	Target Neighborhood Hits	147	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

PA24D_MOUSE
θ value	0.0113563 (rank : 59)	NC score	0.310988 (rank : 72)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

CPNE8_HUMAN
θ value	0.0148317 (rank : 60)	NC score	0.207394 (rank : 88)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	68
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

DYSF_HUMAN
θ value	0.0148317 (rank : 61)	NC score	0.358265 (rank : 65)
Query Neighborhood Hits	117	Target Neighborhood Hits	170	Shared Neighborhood Hits	97
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

RIMS2_HUMAN
θ value	0.0148317 (rank : 62)	NC score	0.363759 (rank : 60)
Query Neighborhood Hits	117	Target Neighborhood Hits	342	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

FA62A_HUMAN
θ value	0.0193708 (rank : 63)	NC score	0.467249 (rank : 43)
Query Neighborhood Hits	117	Target Neighborhood Hits	168	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RASL1_HUMAN
θ value	0.0193708 (rank : 64)	NC score	0.424033 (rank : 50)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	90
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

FA62A_MOUSE
θ value	0.0252991 (rank : 65)	NC score	0.479886 (rank : 40)
Query Neighborhood Hits	117	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

ITSN2_HUMAN
θ value	0.0330416 (rank : 66)	NC score	0.169336 (rank : 107)
Query Neighborhood Hits	117	Target Neighborhood Hits	1173	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RASL1_MOUSE
θ value	0.0431538 (rank : 67)	NC score	0.404982 (rank : 53)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYTL4_MOUSE
θ value	0.0431538 (rank : 68)	NC score	0.473968 (rank : 42)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_HUMAN
θ value	0.0563607 (rank : 69)	NC score	0.478604 (rank : 41)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

ITSN2_MOUSE
θ value	0.0736092 (rank : 70)	NC score	0.157595 (rank : 112)
Query Neighborhood Hits	117	Target Neighborhood Hits	1371	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PA24D_HUMAN
θ value	0.0736092 (rank : 71)	NC score	0.273215 (rank : 77)
Query Neighborhood Hits	117	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RIMS1_HUMAN
θ value	0.0736092 (rank : 72)	NC score	0.347284 (rank : 67)
Query Neighborhood Hits	117	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

CPNE8_MOUSE
θ value	0.125558 (rank : 73)	NC score	0.198768 (rank : 95)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

RFIP2_HUMAN
θ value	0.163984 (rank : 74)	NC score	0.352371 (rank : 66)
Query Neighborhood Hits	117	Target Neighborhood Hits	97	Shared Neighborhood Hits	72
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

ITSN1_HUMAN
θ value	0.21417 (rank : 75)	NC score	0.116297 (rank : 128)
Query Neighborhood Hits	117	Target Neighborhood Hits	1757	Shared Neighborhood Hits	90
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.21417 (rank : 76)	NC score	0.117560 (rank : 127)
Query Neighborhood Hits	117	Target Neighborhood Hits	1669	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CPNE5_HUMAN
θ value	0.365318 (rank : 77)	NC score	0.201599 (rank : 93)
Query Neighborhood Hits	117	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	0.365318 (rank : 78)	NC score	0.202168 (rank : 91)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

RASA3_MOUSE
θ value	0.365318 (rank : 79)	NC score	0.251892 (rank : 79)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RASA3_HUMAN
θ value	0.47712 (rank : 80)	NC score	0.287878 (rank : 75)
Query Neighborhood Hits	117	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

SYT15_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.495361 (rank : 38)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

CPNE2_MOUSE
θ value	0.813845 (rank : 82)	NC score	0.191050 (rank : 96)
Query Neighborhood Hits	117	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

K0100_MOUSE
θ value	0.813845 (rank : 83)	NC score	0.026927 (rank : 160)
Query Neighborhood Hits	117	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

SYNE1_HUMAN
θ value	0.813845 (rank : 84)	NC score	0.010491 (rank : 169)
Query Neighborhood Hits	117	Target Neighborhood Hits	1484	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CDC16_HUMAN
θ value	1.06291 (rank : 85)	NC score	0.026505 (rank : 161)
Query Neighborhood Hits	117	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q13042, Q96AE6, Q9Y564	Gene names	CDC16
Domain Architecture
Description	Cell division cycle protein 16 homolog (CDC16Hs) (Anaphase-promoting complex subunit 6) (APC6) (Cyclosome subunit 6).

TSP3_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.013516 (rank : 165)
Query Neighborhood Hits	117	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

MMGL_MOUSE
θ value	1.38821 (rank : 87)	NC score	0.009603 (rank : 170)
Query Neighborhood Hits	117	Target Neighborhood Hits	270	Shared Neighborhood Hits	3
SwissProt Accessions	P49300	Gene names	Mgl1, Mgl
Domain Architecture
Description	Macrophage asialoglycoprotein-binding protein 1 (M-ASGP-BP) (Macrophage galactose/N-acetylgalactosamine-specific lectin) (MMGL).

RFIP1_MOUSE
θ value	1.38821 (rank : 88)	NC score	0.163859 (rank : 111)
Query Neighborhood Hits	117	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

TSP3_MOUSE
θ value	1.81305 (rank : 89)	NC score	0.012542 (rank : 168)
Query Neighborhood Hits	117	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

BAIP2_HUMAN
θ value	2.36792 (rank : 90)	NC score	0.031767 (rank : 158)
Query Neighborhood Hits	117	Target Neighborhood Hits	192	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

K0528_HUMAN
θ value	2.36792 (rank : 91)	NC score	0.328663 (rank : 68)
Query Neighborhood Hits	117	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
θ value	2.36792 (rank : 92)	NC score	0.328160 (rank : 69)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

NOP14_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.017205 (rank : 162)
Query Neighborhood Hits	117	Target Neighborhood Hits	573	Shared Neighborhood Hits	8
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

PLCD1_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.135838 (rank : 120)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

SYTL2_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.442741 (rank : 47)
Query Neighborhood Hits	117	Target Neighborhood Hits	248	Shared Neighborhood Hits	87
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TULP4_HUMAN
θ value	2.36792 (rank : 96)	NC score	0.016951 (rank : 163)
Query Neighborhood Hits	117	Target Neighborhood Hits	426	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

BAIP2_MOUSE
θ value	3.0926 (rank : 97)	NC score	0.030871 (rank : 159)
Query Neighborhood Hits	117	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

CO7A1_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.002280 (rank : 173)
Query Neighborhood Hits	117	Target Neighborhood Hits	807	Shared Neighborhood Hits	4
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CPNE2_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.188448 (rank : 99)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

GPC6A_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.007641 (rank : 171)
Query Neighborhood Hits	117	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Z6, Q5DK51, Q5DK52	Gene names	Gprc6a
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor.

PA24E_MOUSE
θ value	3.0926 (rank : 101)	NC score	0.190431 (rank : 97)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	75
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

SYTL2_MOUSE
θ value	3.0926 (rank : 102)	NC score	0.438466 (rank : 48)
Query Neighborhood Hits	117	Target Neighborhood Hits	253	Shared Neighborhood Hits	90
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

CPNE3_HUMAN
θ value	4.03905 (rank : 103)	NC score	0.202732 (rank : 90)
Query Neighborhood Hits	117	Target Neighborhood Hits	90	Shared Neighborhood Hits	67
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CROCC_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.005253 (rank : 172)
Query Neighborhood Hits	117	Target Neighborhood Hits	1409	Shared Neighborhood Hits	17
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CPNE3_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.200565 (rank : 94)
Query Neighborhood Hits	117	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

DZIP3_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.013884 (rank : 164)
Query Neighborhood Hits	117	Target Neighborhood Hits	414	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

POTE8_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.002228 (rank : 174)
Query Neighborhood Hits	117	Target Neighborhood Hits	337	Shared Neighborhood Hits	3
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

SYT14_MOUSE
θ value	5.27518 (rank : 108)	NC score	0.393025 (rank : 55)
Query Neighborhood Hits	117	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYTL3_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.397276 (rank : 54)
Query Neighborhood Hits	117	Target Neighborhood Hits	110	Shared Neighborhood Hits	70
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

DZIP3_HUMAN
θ value	6.88961 (rank : 110)	NC score	0.013274 (rank : 166)
Query Neighborhood Hits	117	Target Neighborhood Hits	399	Shared Neighborhood Hits	7
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

HD_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.013096 (rank : 167)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

MIB2_HUMAN
θ value	6.88961 (rank : 112)	NC score	0.001047 (rank : 175)
Query Neighborhood Hits	117	Target Neighborhood Hits	438	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

PCDBF_HUMAN
θ value	6.88961 (rank : 113)	NC score	-0.000426 (rank : 176)
Query Neighborhood Hits	117	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5E8, Q8IUX5	Gene names	PCDHB15
Domain Architecture
Description	Protocadherin beta 15 precursor (PCDH-beta15).

PA24A_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.167897 (rank : 109)
Query Neighborhood Hits	117	Target Neighborhood Hits	88	Shared Neighborhood Hits	71
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24A_MOUSE
θ value	8.99809 (rank : 115)	NC score	0.179214 (rank : 103)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PA24E_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.179397 (rank : 102)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	72
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

SYT14_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.386848 (rank : 56)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

CHIN_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.053824 (rank : 151)
Query Neighborhood Hits	117	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.054284 (rank : 148)
Query Neighborhood Hits	117	Target Neighborhood Hits	229	Shared Neighborhood Hits	9
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.054984 (rank : 146)
Query Neighborhood Hits	117	Target Neighborhood Hits	220	Shared Neighborhood Hits	9
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.058249 (rank : 142)
Query Neighborhood Hits	117	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CPNE1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.150642 (rank : 115)
Query Neighborhood Hits	117	Target Neighborhood Hits	70	Shared Neighborhood Hits	59
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE1_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.169183 (rank : 108)
Query Neighborhood Hits	117	Target Neighborhood Hits	83	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

CPNE4_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.127350 (rank : 123)
Query Neighborhood Hits	117	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.126076 (rank : 124)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

CPNE6_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.135636 (rank : 121)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.134774 (rank : 122)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE7_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.151627 (rank : 114)
Query Neighborhood Hits	117	Target Neighborhood Hits	92	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

DGKQ_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.063257 (rank : 135)
Query Neighborhood Hits	117	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

GRP3_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.097023 (rank : 129)
Query Neighborhood Hits	117	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.051295 (rank : 155)
Query Neighborhood Hits	117	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.051345 (rank : 154)
Query Neighborhood Hits	117	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITCH_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.062539 (rank : 137)
Query Neighborhood Hits	117	Target Neighborhood Hits	162	Shared Neighborhood Hits	24
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.060658 (rank : 139)
Query Neighborhood Hits	117	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

K0317_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.053957 (rank : 150)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.054038 (rank : 149)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

MYRIP_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.051502 (rank : 153)
Query Neighborhood Hits	117	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

P3C2A_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.204188 (rank : 89)
Query Neighborhood Hits	117	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.201809 (rank : 92)
Query Neighborhood Hits	117	Target Neighborhood Hits	181	Shared Neighborhood Hits	63
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.239687 (rank : 83)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.053593 (rank : 152)
Query Neighborhood Hits	117	Target Neighborhood Hits	113	Shared Neighborhood Hits	51
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PA24B_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.190388 (rank : 98)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	66
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24B_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.248536 (rank : 81)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	71
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

PA24F_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.125466 (rank : 126)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	61
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PA24F_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.153807 (rank : 113)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

PDZD8_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.059493 (rank : 141)
Query Neighborhood Hits	117	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PERF_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.058082 (rank : 143)
Query Neighborhood Hits	117	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PERF_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.057684 (rank : 144)
Query Neighborhood Hits	117	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

PLCD1_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.092100 (rank : 131)
Query Neighborhood Hits	117	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

RASA2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.272228 (rank : 78)
Query Neighborhood Hits	117	Target Neighborhood Hits	157	Shared Neighborhood Hits	71
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA2_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.279173 (rank : 76)
Query Neighborhood Hits	117	Target Neighborhood Hits	159	Shared Neighborhood Hits	74
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASF1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.063126 (rank : 136)
Query Neighborhood Hits	117	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.076693 (rank : 133)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	9
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RFIP1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.140693 (rank : 116)
Query Neighborhood Hits	117	Target Neighborhood Hits	236	Shared Neighborhood Hits	39
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RGS3_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.126055 (rank : 125)
Query Neighborhood Hits	117	Target Neighborhood Hits	1375	Shared Neighborhood Hits	67
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RIMS3_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.216393 (rank : 86)
Query Neighborhood Hits	117	Target Neighborhood Hits	66	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.209036 (rank : 87)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS4_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.248358 (rank : 82)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.249916 (rank : 80)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SMUF1_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.137531 (rank : 117)
Query Neighborhood Hits	117	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.136779 (rank : 118)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.136130 (rank : 119)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

STAC_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.051085 (rank : 156)
Query Neighborhood Hits	117	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYT13_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.415976 (rank : 51)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.409000 (rank : 52)
Query Neighborhood Hits	117	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT15_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.459933 (rank : 44)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYT8_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.090539 (rank : 132)
Query Neighborhood Hits	117	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

TAC2N_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.230015 (rank : 84)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.226538 (rank : 85)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TOLIP_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.050243 (rank : 157)
Query Neighborhood Hits	117	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

WWC1_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.071418 (rank : 134)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.093820 (rank : 130)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWP1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.060107 (rank : 140)
Query Neighborhood Hits	117	Target Neighborhood Hits	262	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.060982 (rank : 138)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.054915 (rank : 147)
Query Neighborhood Hits	117	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.056023 (rank : 145)
Query Neighborhood Hits	117	Target Neighborhood Hits	118	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

UN13D_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

BAIP3_HUMAN
NC score	0.937723 (rank : 2)	θ value	9.85132e-148 (rank : 2)
Query Neighborhood Hits	117	Target Neighborhood Hits	108	Shared Neighborhood Hits	80
SwissProt Accessions	O94812, O94839, Q2M226, Q658J2, Q76N05, Q96RZ3, Q9UJK1	Gene names	BAIAP3, KIAA0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

BAIP3_MOUSE
NC score	0.936288 (rank : 3)	θ value	2.35023e-141 (rank : 3)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

SYT7_HUMAN
NC score	0.608975 (rank : 4)	θ value	2.79066e-09 (rank : 13)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
NC score	0.608907 (rank : 5)	θ value	2.13673e-09 (rank : 12)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT5_HUMAN
NC score	0.607940 (rank : 6)	θ value	3.29651e-10 (rank : 8)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	98
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT1_HUMAN
NC score	0.603786 (rank : 7)	θ value	1.25267e-09 (rank : 10)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.603765 (rank : 8)	θ value	1.25267e-09 (rank : 11)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	98
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT3_HUMAN
NC score	0.602073 (rank : 9)	θ value	1.06045e-08 (rank : 16)
Query Neighborhood Hits	117	Target Neighborhood Hits	145	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT5_MOUSE
NC score	0.601195 (rank : 10)	θ value	2.21117e-06 (rank : 28)
Query Neighborhood Hits	117	Target Neighborhood Hits	140	Shared Neighborhood Hits	98
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT3_MOUSE
NC score	0.600557 (rank : 11)	θ value	3.08544e-08 (rank : 17)
Query Neighborhood Hits	117	Target Neighborhood Hits	147	Shared Neighborhood Hits	98
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

UN13B_HUMAN
NC score	0.598864 (rank : 12)	θ value	1.85889e-29 (rank : 4)
Query Neighborhood Hits	117	Target Neighborhood Hits	217	Shared Neighborhood Hits	88
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT10_MOUSE
NC score	0.597938 (rank : 13)	θ value	7.59969e-07 (rank : 24)
Query Neighborhood Hits	117	Target Neighborhood Hits	133	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT2_MOUSE
NC score	0.597529 (rank : 14)	θ value	2.52405e-10 (rank : 7)
Query Neighborhood Hits	117	Target Neighborhood Hits	143	Shared Neighborhood Hits	98
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT6_HUMAN
NC score	0.597521 (rank : 15)	θ value	6.21693e-09 (rank : 14)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	96
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
NC score	0.597479 (rank : 16)	θ value	8.11959e-09 (rank : 15)
Query Neighborhood Hits	117	Target Neighborhood Hits	132	Shared Neighborhood Hits	96
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT2_HUMAN
NC score	0.596855 (rank : 17)	θ value	7.34386e-10 (rank : 9)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT10_HUMAN
NC score	0.595392 (rank : 18)	θ value	8.97725e-08 (rank : 20)
Query Neighborhood Hits	117	Target Neighborhood Hits	134	Shared Neighborhood Hits	96
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT9_HUMAN
NC score	0.591089 (rank : 19)	θ value	5.81887e-07 (rank : 23)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	97
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.585406 (rank : 20)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	97
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

DOC2B_HUMAN
NC score	0.585280 (rank : 21)	θ value	0.00020696 (rank : 44)
Query Neighborhood Hits	117	Target Neighborhood Hits	150	Shared Neighborhood Hits	97
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
NC score	0.583775 (rank : 22)	θ value	7.1131e-05 (rank : 40)
Query Neighborhood Hits	117	Target Neighborhood Hits	169	Shared Neighborhood Hits	97
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2A_HUMAN
NC score	0.579311 (rank : 23)	θ value	0.000270298 (rank : 45)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	97
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

UN13A_HUMAN
NC score	0.578258 (rank : 24)	θ value	7.0802e-21 (rank : 5)
Query Neighborhood Hits	117	Target Neighborhood Hits	285	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SYT4_MOUSE
NC score	0.576483 (rank : 25)	θ value	7.59969e-07 (rank : 25)
Query Neighborhood Hits	117	Target Neighborhood Hits	123	Shared Neighborhood Hits	92
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

DOC2G_MOUSE
NC score	0.576066 (rank : 26)	θ value	2.21117e-06 (rank : 27)
Query Neighborhood Hits	117	Target Neighborhood Hits	125	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

DOC2A_MOUSE
NC score	0.575682 (rank : 27)	θ value	0.000461057 (rank : 50)
Query Neighborhood Hits	117	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

UN13B_MOUSE
NC score	0.574829 (rank : 28)	θ value	9.56915e-18 (rank : 6)
Query Neighborhood Hits	117	Target Neighborhood Hits	210	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SYT4_HUMAN
NC score	0.570018 (rank : 29)	θ value	1.09739e-05 (rank : 33)
Query Neighborhood Hits	117	Target Neighborhood Hits	121	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT11_MOUSE
NC score	0.569390 (rank : 30)	θ value	2.88788e-06 (rank : 31)
Query Neighborhood Hits	117	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_HUMAN
NC score	0.568363 (rank : 31)	θ value	2.88788e-06 (rank : 30)
Query Neighborhood Hits	117	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

RP3A_HUMAN
NC score	0.556586 (rank : 32)	θ value	7.1131e-05 (rank : 41)
Query Neighborhood Hits	117	Target Neighborhood Hits	305	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
NC score	0.553134 (rank : 33)	θ value	4.1701e-05 (rank : 38)
Query Neighborhood Hits	117	Target Neighborhood Hits	510	Shared Neighborhood Hits	99
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT8_MOUSE
NC score	0.512302 (rank : 34)	θ value	1.29631e-06 (rank : 26)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	77
SwissProt Accessions	Q9R0N6, Q64366, Q8C6E7	Gene names	Syt8
Domain Architecture
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

SYT12_MOUSE
NC score	0.510833 (rank : 35)	θ value	0.000158464 (rank : 43)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q920N7	Gene names	Syt12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

SYT12_HUMAN
NC score	0.499320 (rank : 36)	θ value	0.00175202 (rank : 54)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IV01	Gene names	SYT12
Domain Architecture
Description	Synaptotagmin-12 (Synaptotagmin XII) (SytXII).

RASL2_HUMAN
NC score	0.498293 (rank : 37)	θ value	2.88788e-06 (rank : 29)
Query Neighborhood Hits	117	Target Neighborhood Hits	161	Shared Neighborhood Hits	96
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SYT15_HUMAN
NC score	0.495361 (rank : 38)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYTL1_HUMAN
NC score	0.486066 (rank : 39)	θ value	0.000121331 (rank : 42)
Query Neighborhood Hits	117	Target Neighborhood Hits	227	Shared Neighborhood Hits	82
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

FA62A_MOUSE
NC score	0.479886 (rank : 40)	θ value	0.0252991 (rank : 65)
Query Neighborhood Hits	117	Target Neighborhood Hits	155	Shared Neighborhood Hits	93
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL4_HUMAN
NC score	0.478604 (rank : 41)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	79
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

SYTL4_MOUSE
NC score	0.473968 (rank : 42)	θ value	0.0431538 (rank : 68)
Query Neighborhood Hits	117	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

FA62A_HUMAN
NC score	0.467249 (rank : 43)	θ value	0.0193708 (rank : 63)
Query Neighborhood Hits	117	Target Neighborhood Hits	168	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT15_MOUSE
NC score	0.459933 (rank : 44)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C6N3, Q7TN81, Q7TN82, Q8C999	Gene names	Syt15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV).

SYTL5_HUMAN
NC score	0.455399 (rank : 45)	θ value	0.000461057 (rank : 51)
Query Neighborhood Hits	117	Target Neighborhood Hits	237	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL5_MOUSE
NC score	0.453158 (rank : 46)	θ value	0.00665767 (rank : 57)
Query Neighborhood Hits	117	Target Neighborhood Hits	154	Shared Neighborhood Hits	90
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL2_HUMAN
NC score	0.442741 (rank : 47)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	117	Target Neighborhood Hits	248	Shared Neighborhood Hits	87
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL2_MOUSE
NC score	0.438466 (rank : 48)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	117	Target Neighborhood Hits	253	Shared Neighborhood Hits	90
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL1_MOUSE
NC score	0.433604 (rank : 49)	θ value	0.000602161 (rank : 52)
Query Neighborhood Hits	117	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q99N80, Q99J26	Gene names	Sytl1, Slp1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7).

RASL1_HUMAN
NC score	0.424033 (rank : 50)	θ value	0.0193708 (rank : 64)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	90
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYT13_HUMAN
NC score	0.415976 (rank : 51)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	63
SwissProt Accessions	Q7L8C5, Q9BQS3, Q9H041, Q9P2C0	Gene names	SYT13, KIAA1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

SYT13_MOUSE
NC score	0.409000 (rank : 52)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	117	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q9EQT6, Q6ZPR2, Q8BRK6	Gene names	Syt13, Kiaa1427
Domain Architecture	No domain graphic available
Description	Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII).

RASL1_MOUSE
NC score	0.404982 (rank : 53)	θ value	0.0431538 (rank : 67)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

SYTL3_MOUSE
NC score	0.397276 (rank : 54)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	117	Target Neighborhood Hits	110	Shared Neighborhood Hits	70
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYT14_MOUSE
NC score	0.393025 (rank : 55)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	117	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TN84	Gene names	Syt14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

SYT14_HUMAN
NC score	0.386848 (rank : 56)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	55
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

MYOF_HUMAN
NC score	0.377926 (rank : 57)	θ value	0.0113563 (rank : 58)
Query Neighborhood Hits	117	Target Neighborhood Hits	147	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM1, Q9HBU3, Q9NZM0, Q9ULL3, Q9Y4U4	Gene names	FER1L3, KIAA1207, MYOF
Domain Architecture
Description	Myoferlin (Fer-1-like protein 3).

PCLO_HUMAN
NC score	0.377415 (rank : 58)	θ value	1.87187e-05 (rank : 35)
Query Neighborhood Hits	117	Target Neighborhood Hits	2046	Shared Neighborhood Hits	96
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

DYSF_MOUSE
NC score	0.365045 (rank : 59)	θ value	0.00228821 (rank : 55)
Query Neighborhood Hits	117	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESD7, Q9QXC0	Gene names	Dysf, Fer1l1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

RIMS2_HUMAN
NC score	0.363759 (rank : 60)	θ value	0.0148317 (rank : 62)
Query Neighborhood Hits	117	Target Neighborhood Hits	342	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

OTOF_HUMAN
NC score	0.362078 (rank : 61)	θ value	0.000270298 (rank : 47)
Query Neighborhood Hits	117	Target Neighborhood Hits	168	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HC10, Q9HC08, Q9HC09, Q9Y650	Gene names	OTOF, FER1L2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

RIMS2_MOUSE
NC score	0.361029 (rank : 62)	θ value	0.00509761 (rank : 56)
Query Neighborhood Hits	117	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

OTOF_MOUSE
NC score	0.358568 (rank : 63)	θ value	0.00035302 (rank : 49)
Query Neighborhood Hits	117	Target Neighborhood Hits	196	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PCLO_MOUSE
NC score	0.358353 (rank : 64)	θ value	6.43352e-06 (rank : 32)
Query Neighborhood Hits	117	Target Neighborhood Hits	2275	Shared Neighborhood Hits	100
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

DYSF_HUMAN
NC score	0.358265 (rank : 65)	θ value	0.0148317 (rank : 61)
Query Neighborhood Hits	117	Target Neighborhood Hits	170	Shared Neighborhood Hits	97
SwissProt Accessions	O75923, O75696, Q9UEN7	Gene names	DYSF, FER1L1
Domain Architecture
Description	Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1).

RFIP2_HUMAN
NC score	0.352371 (rank : 66)	θ value	0.163984 (rank : 74)
Query Neighborhood Hits	117	Target Neighborhood Hits	97	Shared Neighborhood Hits	72
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

RIMS1_HUMAN
NC score	0.347284 (rank : 67)	θ value	0.0736092 (rank : 72)
Query Neighborhood Hits	117	Target Neighborhood Hits	437	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

K0528_HUMAN
NC score	0.328663 (rank : 68)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	117	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q86YS7, O60280, Q7Z619, Q86SU3	Gene names	KIAA0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K0528_MOUSE
NC score	0.328160 (rank : 69)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

NED4L_HUMAN
NC score	0.322161 (rank : 70)	θ value	8.97725e-08 (rank : 18)
Query Neighborhood Hits	117	Target Neighborhood Hits	238	Shared Neighborhood Hits	94
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.319022 (rank : 71)	θ value	8.97725e-08 (rank : 19)
Query Neighborhood Hits	117	Target Neighborhood Hits	231	Shared Neighborhood Hits	93
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PA24D_MOUSE
NC score	0.310988 (rank : 72)	θ value	0.0113563 (rank : 59)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	Q50L43, Q3TJC5	Gene names	Pla2g4d
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

NEDD4_HUMAN
NC score	0.294176 (rank : 73)	θ value	0.000270298 (rank : 46)
Query Neighborhood Hits	117	Target Neighborhood Hits	214	Shared Neighborhood Hits	94
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
NC score	0.290107 (rank : 74)	θ value	0.000786445 (rank : 53)
Query Neighborhood Hits	117	Target Neighborhood Hits	212	Shared Neighborhood Hits	94
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

RASA3_HUMAN
NC score	0.287878 (rank : 75)	θ value	0.47712 (rank : 80)
Query Neighborhood Hits	117	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RASA2_MOUSE
NC score	0.279173 (rank : 76)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	117	Target Neighborhood Hits	159	Shared Neighborhood Hits	74
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

PA24D_HUMAN
NC score	0.273215 (rank : 77)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	117	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q86XP0, Q8N176	Gene names	PLA2G4D
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 delta (EC 3.1.1.4) (cPLA2-delta) (Phospholipase A2 group IVD).

RASA2_HUMAN
NC score	0.272228 (rank : 78)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	117	Target Neighborhood Hits	157	Shared Neighborhood Hits	71
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RASA3_MOUSE
NC score	0.251892 (rank : 79)	θ value	0.365318 (rank : 79)
Query Neighborhood Hits	117	Target Neighborhood Hits	144	Shared Neighborhood Hits	69
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RIMS4_MOUSE
NC score	0.249916 (rank : 80)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

PA24B_MOUSE
NC score	0.248536 (rank : 81)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	117	Target Neighborhood Hits	102	Shared Neighborhood Hits	71
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RIMS4_HUMAN
NC score	0.248358 (rank : 82)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

P3C2B_HUMAN
NC score	0.239687 (rank : 83)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	117	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

TAC2N_HUMAN
NC score	0.230015 (rank : 84)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N9U0	Gene names	MTAC2D1, C14orf47
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

TAC2N_MOUSE
NC score	0.226538 (rank : 85)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q91XT6, Q9D4A0	Gene names	Mtac2d1
Domain Architecture
Description	Membrane targeting tandem C2 domain-containing protein 1 (Tandem C2 protein in nucleus) (Tac2-N).

RIMS3_HUMAN
NC score	0.216393 (rank : 86)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	117	Target Neighborhood Hits	66	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UJD0, Q92511	Gene names	RIMS3, KIAA0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

RIMS3_MOUSE
NC score	0.209036 (rank : 87)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q80U57	Gene names	Rims3, Kiaa0237
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 3 (Nim3) (Rab-3- interacting molecule 3) (RIM 3) (RIM3 gamma).

CPNE8_HUMAN
NC score	0.207394 (rank : 88)	θ value	0.0148317 (rank : 60)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	68
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

P3C2A_HUMAN
NC score	0.204188 (rank : 89)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	117	Target Neighborhood Hits	188	Shared Neighborhood Hits	62
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

CPNE3_HUMAN
NC score	0.202732 (rank : 90)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	117	Target Neighborhood Hits	90	Shared Neighborhood Hits	67
SwissProt Accessions	O75131, Q8IYA1	Gene names	CPNE3, CPN3, KIAA0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE5_MOUSE
NC score	0.202168 (rank : 91)	θ value	0.365318 (rank : 78)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

P3C2A_MOUSE
NC score	0.201809 (rank : 92)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	117	Target Neighborhood Hits	181	Shared Neighborhood Hits	63
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

CPNE5_HUMAN
NC score	0.201599 (rank : 93)	θ value	0.365318 (rank : 77)
Query Neighborhood Hits	117	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE3_MOUSE
NC score	0.200565 (rank : 94)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	117	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BT60, Q5CZX9, Q5DU22	Gene names	Cpne3, Kiaa0636
Domain Architecture
Description	Copine-3 (Copine III).

CPNE8_MOUSE
NC score	0.198768 (rank : 95)	θ value	0.125558 (rank : 73)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

CPNE2_MOUSE
NC score	0.191050 (rank : 96)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	117	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	P59108, Q8K1D7	Gene names	Cpne2
Domain Architecture
Description	Copine-2 (Copine II).

PA24E_MOUSE
NC score	0.190431 (rank : 97)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	75
SwissProt Accessions	Q50L42, Q8BX44	Gene names	Pla2g4e
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24B_HUMAN
NC score	0.190388 (rank : 98)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	66
SwissProt Accessions	O95712, Q59GF9, Q8TB10, Q9UKV7	Gene names	PLA2G4B
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CPNE2_HUMAN
NC score	0.188448 (rank : 99)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	60
SwissProt Accessions	Q96FN4, Q68D19, Q86XP9	Gene names	CPNE2
Domain Architecture
Description	Copine-2 (Copine II).

KPCG_HUMAN
NC score	0.183991 (rank : 100)	θ value	3.19293e-05 (rank : 36)
Query Neighborhood Hits	117	Target Neighborhood Hits	1126	Shared Neighborhood Hits	96
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
NC score	0.183556 (rank : 101)	θ value	3.19293e-05 (rank : 37)
Query Neighborhood Hits	117	Target Neighborhood Hits	1123	Shared Neighborhood Hits	96
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PA24E_HUMAN
NC score	0.179397 (rank : 102)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	72
SwissProt Accessions	Q3MJ16, Q6ZSC0	Gene names	PLA2G4E
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 epsilon (EC 3.1.1.4) (cPLA2-epsilon) (Phospholipase A2 group IVE).

PA24A_MOUSE
NC score	0.179214 (rank : 103)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

KPCA_HUMAN
NC score	0.173191 (rank : 104)	θ value	1.99992e-07 (rank : 22)
Query Neighborhood Hits	117	Target Neighborhood Hits	1070	Shared Neighborhood Hits	98
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
NC score	0.171345 (rank : 105)	θ value	1.17247e-07 (rank : 21)
Query Neighborhood Hits	117	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_MOUSE
NC score	0.170336 (rank : 106)	θ value	5.44631e-05 (rank : 39)
Query Neighborhood Hits	117	Target Neighborhood Hits	1117	Shared Neighborhood Hits	97
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

ITSN2_HUMAN
NC score	0.169336 (rank : 107)	θ value	0.0330416 (rank : 66)
Query Neighborhood Hits	117	Target Neighborhood Hits	1173	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CPNE1_MOUSE
NC score	0.169183 (rank : 108)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	117	Target Neighborhood Hits	83	Shared Neighborhood Hits	64
SwissProt Accessions	Q8C166, Q925K4, Q925K5	Gene names	Cpne1
Domain Architecture
Description	Copine-1 (Copine I).

PA24A_HUMAN
NC score	0.167897 (rank : 109)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	117	Target Neighborhood Hits	88	Shared Neighborhood Hits	71
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

KPCB_HUMAN
NC score	0.166514 (rank : 110)	θ value	0.00035302 (rank : 48)
Query Neighborhood Hits	117	Target Neighborhood Hits	1121	Shared Neighborhood Hits	97
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

RFIP1_MOUSE
NC score	0.163859 (rank : 111)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	117	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ITSN2_MOUSE
NC score	0.157595 (rank : 112)	θ value	0.0736092 (rank : 70)
Query Neighborhood Hits	117	Target Neighborhood Hits	1371	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PA24F_MOUSE
NC score	0.153807 (rank : 113)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q50L41, Q80VQ8, Q80VV9	Gene names	Pla2g4f
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

CPNE7_HUMAN
NC score	0.151627 (rank : 114)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	117	Target Neighborhood Hits	92	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UBL6	Gene names	CPNE7
Domain Architecture
Description	Copine-7 (Copine VII).

CPNE1_HUMAN
NC score	0.150642 (rank : 115)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	117	Target Neighborhood Hits	70	Shared Neighborhood Hits	59
SwissProt Accessions	Q99829, Q6IBL3, Q9H243, Q9NTZ7	Gene names	CPNE1, CPN1
Domain Architecture
Description	Copine-1 (Copine I).

RFIP1_HUMAN
NC score	0.140693 (rank : 116)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	117	Target Neighborhood Hits	236	Shared Neighborhood Hits	39
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SMUF1_HUMAN
NC score	0.137531 (rank : 117)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	117	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.136779 (rank : 118)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	58
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.136130 (rank : 119)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	117	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

PLCD1_HUMAN
NC score	0.135838 (rank : 120)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	52
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

CPNE6_HUMAN
NC score	0.135636 (rank : 121)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	59
SwissProt Accessions	O95741, Q53HA6, Q8WVG1	Gene names	CPNE6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE6_MOUSE
NC score	0.134774 (rank : 122)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Z140	Gene names	Cpne6
Domain Architecture
Description	Copine-6 (Copine VI) (Neuronal-copine) (N-copine).

CPNE4_HUMAN
NC score	0.127350 (rank : 123)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	117	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	Q96A23, Q8TEX1	Gene names	CPNE4
Domain Architecture
Description	Copine-4 (Copine IV) (Copine-8).

CPNE4_MOUSE
NC score	0.126076 (rank : 124)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BLR2	Gene names	Cpne4
Domain Architecture	No domain graphic available
Description	Copine-4 (Copine IV).

RGS3_HUMAN
NC score	0.126055 (rank : 125)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	117	Target Neighborhood Hits	1375	Shared Neighborhood Hits	67
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

PA24F_HUMAN
NC score	0.125466 (rank : 126)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	61
SwissProt Accessions	Q68DD2, Q6ZMC8	Gene names	PLA2G4F
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 zeta (EC 3.1.1.4) (cPLA2-zeta) (Phospholipase A2 group IVF).

ITSN1_MOUSE
NC score	0.117560 (rank : 127)	θ value	0.21417 (rank : 76)
Query Neighborhood Hits	117	Target Neighborhood Hits	1669	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.116297 (rank : 128)	θ value	0.21417 (rank : 75)
Query Neighborhood Hits	117	Target Neighborhood Hits	1757	Shared Neighborhood Hits	90
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

GRP3_HUMAN
NC score	0.097023 (rank : 129)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	117	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

WWC1_MOUSE
NC score	0.093820 (rank : 130)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

PLCD1_MOUSE
NC score	0.092100 (rank : 131)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	117	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

SYT8_HUMAN
NC score	0.090539 (rank : 132)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	117	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

RASF1_MOUSE
NC score	0.076693 (rank : 133)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	9
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

WWC1_HUMAN
NC score	0.071418 (rank : 134)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

DGKQ_HUMAN
NC score	0.063257 (rank : 135)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	117	Target Neighborhood Hits	131	Shared Neighborhood Hits	9
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

RASF1_HUMAN
NC score	0.063126 (rank : 136)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	117	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

ITCH_HUMAN
NC score	0.062539 (rank : 137)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	117	Target Neighborhood Hits	162	Shared Neighborhood Hits	24
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_MOUSE
NC score	0.060982 (rank : 138)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
NC score	0.060658 (rank : 139)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	117	Target Neighborhood Hits	127	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
NC score	0.060107 (rank : 140)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	117	Target Neighborhood Hits	262	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

PDZD8_HUMAN
NC score	0.059493 (rank : 141)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	117	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

CHIO_MOUSE
NC score	0.058249 (rank : 142)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	117	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

PERF_HUMAN
NC score	0.058082 (rank : 143)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	117	Target Neighborhood Hits	48	Shared Neighborhood Hits	21
SwissProt Accessions	P14222, Q86WX7	Gene names	PRF1, PFP
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (PFP) (Cytolysin).

PERF_MOUSE
NC score	0.057684 (rank : 144)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	117	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	P10820	Gene names	Prf1, Pfp
Domain Architecture
Description	Perforin-1 precursor (P1) (Lymphocyte pore-forming protein) (Cytolysin).

WWP2_MOUSE
NC score	0.056023 (rank : 145)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	117	Target Neighborhood Hits	118	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

CHIO_HUMAN
NC score	0.054984 (rank : 146)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	117	Target Neighborhood Hits	220	Shared Neighborhood Hits	9
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

WWP2_HUMAN
NC score	0.054915 (rank : 147)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	117	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

CHIN_MOUSE
NC score	0.054284 (rank : 148)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	117	Target Neighborhood Hits	229	Shared Neighborhood Hits	9
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

K0317_MOUSE
NC score	0.054038 (rank : 149)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.053957 (rank : 150)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

CHIN_HUMAN
NC score	0.053824 (rank : 151)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	117	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

P3C2G_MOUSE
NC score	0.053593 (rank : 152)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	117	Target Neighborhood Hits	113	Shared Neighborhood Hits	51
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

MYRIP_MOUSE
NC score	0.051502 (rank : 153)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	117	Target Neighborhood Hits	207	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

HUWE1_MOUSE
NC score	0.051345 (rank : 154)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	117	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.051295 (rank : 155)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	117	Target Neighborhood Hits	443	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

STAC_MOUSE
NC score	0.051085 (rank : 156)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	117	Target Neighborhood Hits	268	Shared Neighborhood Hits	13
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TOLIP_MOUSE
NC score	0.050243 (rank : 157)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	117	Target Neighborhood Hits	24	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

BAIP2_HUMAN
NC score	0.031767 (rank : 158)	θ value	2.36792 (rank : 90)
Query Neighborhood Hits	117	Target Neighborhood Hits	192	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
NC score	0.030871 (rank : 159)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	117	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

K0100_MOUSE
NC score	0.026927 (rank : 160)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	117	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q5SYL3, Q3UE65, Q66JY1, Q6DIC4, Q80U77, Q8C1W6, Q8CE06, Q8CGE3, Q9CSS8	Gene names	Kiaa0100
Domain Architecture	No domain graphic available
Description	UPF0378 family protein KIAA0100 precursor.

CDC16_HUMAN
NC score	0.026505 (rank : 161)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	117	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q13042, Q96AE6, Q9Y564	Gene names	CDC16
Domain Architecture
Description	Cell division cycle protein 16 homolog (CDC16Hs) (Anaphase-promoting complex subunit 6) (APC6) (Cyclosome subunit 6).

NOP14_HUMAN
NC score	0.017205 (rank : 162)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	117	Target Neighborhood Hits	573	Shared Neighborhood Hits	8
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

TULP4_HUMAN
NC score	0.016951 (rank : 163)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	117	Target Neighborhood Hits	426	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

DZIP3_MOUSE
NC score	0.013884 (rank : 164)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	117	Target Neighborhood Hits	414	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

TSP3_HUMAN
NC score	0.013516 (rank : 165)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	117	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

DZIP3_HUMAN
NC score	0.013274 (rank : 166)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	117	Target Neighborhood Hits	399	Shared Neighborhood Hits	7
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

HD_HUMAN
NC score	0.013096 (rank : 167)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

TSP3_MOUSE
NC score	0.012542 (rank : 168)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	117	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

SYNE1_HUMAN
NC score	0.010491 (rank : 169)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	117	Target Neighborhood Hits	1484	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

MMGL_MOUSE
NC score	0.009603 (rank : 170)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	117	Target Neighborhood Hits	270	Shared Neighborhood Hits	3
SwissProt Accessions	P49300	Gene names	Mgl1, Mgl
Domain Architecture
Description	Macrophage asialoglycoprotein-binding protein 1 (M-ASGP-BP) (Macrophage galactose/N-acetylgalactosamine-specific lectin) (MMGL).

GPC6A_MOUSE
NC score	0.007641 (rank : 171)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	117	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Z6, Q5DK51, Q5DK52	Gene names	Gprc6a
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor family C group 6 member A precursor.

CROCC_HUMAN
NC score	0.005253 (rank : 172)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	117	Target Neighborhood Hits	1409	Shared Neighborhood Hits	17
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CO7A1_HUMAN
NC score	0.002280 (rank : 173)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	117	Target Neighborhood Hits	807	Shared Neighborhood Hits	4
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

POTE8_HUMAN
NC score	0.002228 (rank : 174)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	117	Target Neighborhood Hits	337	Shared Neighborhood Hits	3
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

MIB2_HUMAN
NC score	0.001047 (rank : 175)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	117	Target Neighborhood Hits	438	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

PCDBF_HUMAN
NC score	-0.000426 (rank : 176)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	117	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5E8, Q8IUX5	Gene names	PCDHB15
Domain Architecture
Description	Protocadherin beta 15 precursor (PCDH-beta15).