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Network neighborhood for query Sequence : RUNX1_MOUSE

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RUNX1_MOUSE
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RUNX1_HUMAN
θ value	0 (rank : 1)	NC score	0.985454 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX2_HUMAN
θ value	1.68038e-147 (rank : 3)	NC score	0.964163 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX2_MOUSE
θ value	1.20424e-145 (rank : 4)	NC score	0.959613 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	119	Shared Neighborhood Hits	26
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX3_MOUSE
θ value	1.33764e-128 (rank : 5)	NC score	0.955203 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	19
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

RUNX3_HUMAN
θ value	1.47893e-127 (rank : 6)	NC score	0.960016 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

ARI1A_HUMAN
θ value	0.00175202 (rank : 7)	NC score	0.097695 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	787	Shared Neighborhood Hits	36
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

MILK1_MOUSE
θ value	0.00390308 (rank : 8)	NC score	0.061389 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	788	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SC24A_MOUSE
θ value	0.0113563 (rank : 9)	NC score	0.064549 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	394	Shared Neighborhood Hits	23
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

NPAS2_HUMAN
θ value	0.0431538 (rank : 10)	NC score	0.041745 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

BRD8_MOUSE
θ value	0.0736092 (rank : 11)	NC score	0.036434 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	422	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

ATX2L_HUMAN
θ value	0.125558 (rank : 12)	NC score	0.069998 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	443	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

RPB1_MOUSE
θ value	0.125558 (rank : 13)	NC score	0.074242 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	363	Shared Neighborhood Hits	19
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

PRRT3_MOUSE
θ value	0.163984 (rank : 14)	NC score	0.044868 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RPB1_HUMAN
θ value	0.21417 (rank : 15)	NC score	0.073263 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	362	Shared Neighborhood Hits	19
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SRRM2_HUMAN
θ value	0.279714 (rank : 16)	NC score	0.064126 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	1296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ATN1_HUMAN
θ value	0.365318 (rank : 17)	NC score	0.061677 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	676	Shared Neighborhood Hits	28
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

DIAP1_HUMAN
θ value	0.365318 (rank : 18)	NC score	0.022565 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	784	Shared Neighborhood Hits	14
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

UBL7_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.065044 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q96S82, Q96I03	Gene names	UBL7, BMSCUBP
Domain Architecture
Description	Ubiquitin-like protein 7 (Ubiquitin-like protein SB132) (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP).

UBL7_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.065651 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

DYN1_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.018117 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

RBBP6_HUMAN
θ value	0.47712 (rank : 22)	NC score	0.019684 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

PCDH1_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.005660 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q08174	Gene names	PCDH1
Domain Architecture
Description	Protocadherin-1 precursor (Protocadherin-42) (PC42) (Cadherin-like protein 1).

SRRM2_MOUSE
θ value	0.62314 (rank : 24)	NC score	0.064445 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	1470	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TBX15_MOUSE
θ value	0.62314 (rank : 25)	NC score	0.017661 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	O70306, O54840	Gene names	Tbx15, Tbx14, Tbx8
Domain Architecture
Description	T-box transcription factor TBX15 (T-box protein 15) (MmTBx8).

DOT1L_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.056683 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	660	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

SF01_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.053002 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	287	Shared Neighborhood Hits	19
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

MBD6_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.051385 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MUC2_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.048734 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

RUSC2_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.026227 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	305	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TMM28_HUMAN
θ value	1.06291 (rank : 31)	NC score	0.041043 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O75949	Gene names	TMEM28, TED
Domain Architecture	No domain graphic available
Description	Transmembrane protein 28 (TED protein).

EYA1_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.016163 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

HGS_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.033204 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SF01_MOUSE
θ value	1.38821 (rank : 34)	NC score	0.050227 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SFPQ_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.015739 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	986	Shared Neighborhood Hits	20
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

ZN645_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.068058 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

ATX2L_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.066503 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	30
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

EP400_MOUSE
θ value	1.81305 (rank : 38)	NC score	0.025214 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MLL2_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.031586 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	1788	Shared Neighborhood Hits	52
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TBX15_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.016206 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SF7, Q5T9S7	Gene names	TBX15, TBX14
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX15 (T-box protein 15).

TREF1_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.030298 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	682	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

VAX1_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.015036 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	355	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SQQ9, Q6ZSX0	Gene names	VAX1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

VAX1_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.013211 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	351	Shared Neighborhood Hits	8
SwissProt Accessions	Q2NKI2, O88880	Gene names	Vax1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

ZN318_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.019535 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	642	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

CDSN_HUMAN
θ value	2.36792 (rank : 45)	NC score	0.036034 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

CRSP2_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.055096 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

ETV6_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.024541 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

HCN4_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.026035 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	284	Shared Neighborhood Hits	20
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

LTB1L_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.004709 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	514	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

DIAP1_MOUSE
θ value	3.0926 (rank : 50)	NC score	0.017370 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	839	Shared Neighborhood Hits	12
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

MARK3_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.004824 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	893	Shared Neighborhood Hits	11
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.004368 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	919	Shared Neighborhood Hits	12
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PTN23_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.016401 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	726	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SC24D_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.041139 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

SF3A2_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.033005 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	263	Shared Neighborhood Hits	9
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

CD248_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.028459 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	578	Shared Neighborhood Hits	29
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

FOXC1_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.006619 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

P53_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.020543 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

PGCA_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.008175 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	821	Shared Neighborhood Hits	16
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PO6F2_MOUSE
θ value	4.03905 (rank : 60)	NC score	0.026876 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	639	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

RL12_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.041637 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P30050	Gene names	RPL12
Domain Architecture
Description	60S ribosomal protein L12.

RL12_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.041637 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P35979, Q9CQK4	Gene names	Rpl12
Domain Architecture
Description	60S ribosomal protein L12.

SOS1_MOUSE
θ value	4.03905 (rank : 63)	NC score	0.026653 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

WNK2_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.005814 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	1407	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

BAG3_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.014535 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

CUTL1_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.008902 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	1620	Shared Neighborhood Hits	31
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

KCNH3_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.007645 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

NDF4_MOUSE
θ value	5.27518 (rank : 68)	NC score	0.007414 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

RBM14_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.025661 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PK6, O75932, Q53GV1, Q68DQ9, Q96PK5	Gene names	RBM14, SIP
Domain Architecture	No domain graphic available
Description	RNA-binding protein 14 (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein).

RFIP1_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.012310 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	152	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SUOX_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.021549 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P51687	Gene names	SUOX
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

APS_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.007630 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ATX2_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.054899 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	31
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

CRF_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.016665 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P06850	Gene names	CRH
Domain Architecture
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

DMRT1_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.011650 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5R6, Q8IW77	Gene names	DMRT1, DMT1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1).

FOXC1_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.007351 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

M3K9_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.004368 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	1123	Shared Neighborhood Hits	16
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NED4L_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.005325 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PHLA1_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.029785 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

PSL1_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.024893 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RBM14_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.024838 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C2Q3, Q3TJB6, Q91Z21, Q9DBI6	Gene names	Rbm14
Domain Architecture	No domain graphic available
Description	RNA-binding protein 14 (RNA-binding motif protein 14).

US6NL_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.031030 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	201	Shared Neighborhood Hits	16
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

WNK4_HUMAN
θ value	6.88961 (rank : 83)	NC score	0.009800 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	1043	Shared Neighborhood Hits	22
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

3BP1_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.006007 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AMPH_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.016361 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.016656 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	291	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

BCL9_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.033346 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	1008	Shared Neighborhood Hits	50
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

EHMT2_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.005733 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	750	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

M4K4_MOUSE
θ value	8.99809 (rank : 89)	NC score	-0.000268 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	1560	Shared Neighborhood Hits	16
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MYST3_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.019126 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	688	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

PO6F2_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.020799 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	618	Shared Neighborhood Hits	24
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

REPS2_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.018954 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SF3B4_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.009113 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

ZN207_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.051404 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	326	Shared Neighborhood Hits	8
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

Hits sorted by NC score

RUNX1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX1_HUMAN
NC score	0.985454 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX2_HUMAN
NC score	0.964163 (rank : 3)	θ value	1.68038e-147 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX3_HUMAN
NC score	0.960016 (rank : 4)	θ value	1.47893e-127 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

RUNX2_MOUSE
NC score	0.959613 (rank : 5)	θ value	1.20424e-145 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	119	Shared Neighborhood Hits	26
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX3_MOUSE
NC score	0.955203 (rank : 6)	θ value	1.33764e-128 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	19
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

ARI1A_HUMAN
NC score	0.097695 (rank : 7)	θ value	0.00175202 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	787	Shared Neighborhood Hits	36
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

RPB1_MOUSE
NC score	0.074242 (rank : 8)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	363	Shared Neighborhood Hits	19
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_HUMAN
NC score	0.073263 (rank : 9)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	362	Shared Neighborhood Hits	19
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

ATX2L_HUMAN
NC score	0.069998 (rank : 10)	θ value	0.125558 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	443	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

ZN645_HUMAN
NC score	0.068058 (rank : 11)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	26
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

ATX2L_MOUSE
NC score	0.066503 (rank : 12)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	30
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

UBL7_MOUSE
NC score	0.065651 (rank : 13)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q91W67, Q9D7P5	Gene names	Ubl7
Domain Architecture
Description	Ubiquitin-like protein 7.

UBL7_HUMAN
NC score	0.065044 (rank : 14)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	Q96S82, Q96I03	Gene names	UBL7, BMSCUBP
Domain Architecture
Description	Ubiquitin-like protein 7 (Ubiquitin-like protein SB132) (Bone marrow stromal cell ubiquitin-like protein) (BMSC-UbP).

SC24A_MOUSE
NC score	0.064549 (rank : 15)	θ value	0.0113563 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	394	Shared Neighborhood Hits	23
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SRRM2_MOUSE
NC score	0.064445 (rank : 16)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	1470	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SRRM2_HUMAN
NC score	0.064126 (rank : 17)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	1296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ATN1_HUMAN
NC score	0.061677 (rank : 18)	θ value	0.365318 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	676	Shared Neighborhood Hits	28
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

MILK1_MOUSE
NC score	0.061389 (rank : 19)	θ value	0.00390308 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	788	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

DOT1L_HUMAN
NC score	0.056683 (rank : 20)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	660	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

CRSP2_HUMAN
NC score	0.055096 (rank : 21)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

ATX2_MOUSE
NC score	0.054899 (rank : 22)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	31
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

SF01_HUMAN
NC score	0.053002 (rank : 23)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	287	Shared Neighborhood Hits	19
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

ZN207_HUMAN
NC score	0.051404 (rank : 24)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	326	Shared Neighborhood Hits	8
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

MBD6_HUMAN
NC score	0.051385 (rank : 25)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

SF01_MOUSE
NC score	0.050227 (rank : 26)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	240	Shared Neighborhood Hits	13
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

MUC2_HUMAN
NC score	0.048734 (rank : 27)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	906	Shared Neighborhood Hits	30
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

PRRT3_MOUSE
NC score	0.044868 (rank : 28)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

NPAS2_HUMAN
NC score	0.041745 (rank : 29)	θ value	0.0431538 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

RL12_HUMAN
NC score	0.041637 (rank : 30)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P30050	Gene names	RPL12
Domain Architecture
Description	60S ribosomal protein L12.

RL12_MOUSE
NC score	0.041637 (rank : 31)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P35979, Q9CQK4	Gene names	Rpl12
Domain Architecture
Description	60S ribosomal protein L12.

SC24D_HUMAN
NC score	0.041139 (rank : 32)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

TMM28_HUMAN
NC score	0.041043 (rank : 33)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O75949	Gene names	TMEM28, TED
Domain Architecture	No domain graphic available
Description	Transmembrane protein 28 (TED protein).

BRD8_MOUSE
NC score	0.036434 (rank : 34)	θ value	0.0736092 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	422	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

CDSN_HUMAN
NC score	0.036034 (rank : 35)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q15517, O43509, Q5SQ85, Q5STD2, Q7LA70, Q7LA71, Q86Z04, Q8IZU4, Q8IZU5, Q8IZU6, Q8N5P3, Q95IF9, Q9NP52, Q9NPE0, Q9NPG5, Q9NRH4, Q9NRH5, Q9NRH6, Q9NRH7, Q9NRH8, Q9UBH8, Q9UIN6, Q9UIN7, Q9UIN8, Q9UIN9, Q9UIP0	Gene names	CDSN
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor (S protein).

BCL9_HUMAN
NC score	0.033346 (rank : 36)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	1008	Shared Neighborhood Hits	50
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

HGS_MOUSE
NC score	0.033204 (rank : 37)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	589	Shared Neighborhood Hits	23
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SF3A2_HUMAN
NC score	0.033005 (rank : 38)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	263	Shared Neighborhood Hits	9
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

MLL2_HUMAN
NC score	0.031586 (rank : 39)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	1788	Shared Neighborhood Hits	52
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

US6NL_HUMAN
NC score	0.031030 (rank : 40)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	201	Shared Neighborhood Hits	16
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

TREF1_MOUSE
NC score	0.030298 (rank : 41)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	682	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

PHLA1_HUMAN
NC score	0.029785 (rank : 42)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WV24, Q15184, Q2TAN2, Q9NZ17	Gene names	PHLDA1, PHRIP, TDAG51
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family A member 1 (T-cell death- associated gene 51 protein) (Apoptosis-associated nuclear protein) (Proline- and histidine-rich protein) (Proline- and glutamine-rich protein) (PQ-rich protein).

CD248_MOUSE
NC score	0.028459 (rank : 43)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	578	Shared Neighborhood Hits	29
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

PO6F2_MOUSE
NC score	0.026876 (rank : 44)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	639	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

SOS1_MOUSE
NC score	0.026653 (rank : 45)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

RUSC2_MOUSE
NC score	0.026227 (rank : 46)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	305	Shared Neighborhood Hits	11
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

HCN4_MOUSE
NC score	0.026035 (rank : 47)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	284	Shared Neighborhood Hits	20
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

RBM14_HUMAN
NC score	0.025661 (rank : 48)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PK6, O75932, Q53GV1, Q68DQ9, Q96PK5	Gene names	RBM14, SIP
Domain Architecture	No domain graphic available
Description	RNA-binding protein 14 (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein).

EP400_MOUSE
NC score	0.025214 (rank : 49)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	592	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

PSL1_HUMAN
NC score	0.024893 (rank : 50)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RBM14_MOUSE
NC score	0.024838 (rank : 51)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	9
SwissProt Accessions	Q8C2Q3, Q3TJB6, Q91Z21, Q9DBI6	Gene names	Rbm14
Domain Architecture	No domain graphic available
Description	RNA-binding protein 14 (RNA-binding motif protein 14).

ETV6_HUMAN
NC score	0.024541 (rank : 52)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

DIAP1_HUMAN
NC score	0.022565 (rank : 53)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	784	Shared Neighborhood Hits	14
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

SUOX_HUMAN
NC score	0.021549 (rank : 54)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P51687	Gene names	SUOX
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

PO6F2_HUMAN
NC score	0.020799 (rank : 55)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	618	Shared Neighborhood Hits	24
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

P53_HUMAN
NC score	0.020543 (rank : 56)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

RBBP6_HUMAN
NC score	0.019684 (rank : 57)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

ZN318_MOUSE
NC score	0.019535 (rank : 58)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	642	Shared Neighborhood Hits	12
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

MYST3_MOUSE
NC score	0.019126 (rank : 59)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	688	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

REPS2_HUMAN
NC score	0.018954 (rank : 60)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

DYN1_MOUSE
NC score	0.018117 (rank : 61)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

TBX15_MOUSE
NC score	0.017661 (rank : 62)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	O70306, O54840	Gene names	Tbx15, Tbx14, Tbx8
Domain Architecture
Description	T-box transcription factor TBX15 (T-box protein 15) (MmTBx8).

DIAP1_MOUSE
NC score	0.017370 (rank : 63)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	839	Shared Neighborhood Hits	12
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

CRF_HUMAN
NC score	0.016665 (rank : 64)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P06850	Gene names	CRH
Domain Architecture
Description	Corticoliberin precursor (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone).

AMPH_MOUSE
NC score	0.016656 (rank : 65)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	291	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

PTN23_MOUSE
NC score	0.016401 (rank : 66)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	726	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

AMPH_HUMAN
NC score	0.016361 (rank : 67)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

TBX15_HUMAN
NC score	0.016206 (rank : 68)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SF7, Q5T9S7	Gene names	TBX15, TBX14
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX15 (T-box protein 15).

EYA1_MOUSE
NC score	0.016163 (rank : 69)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	P97767, O08818	Gene names	Eya1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

SFPQ_HUMAN
NC score	0.015739 (rank : 70)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	986	Shared Neighborhood Hits	20
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

VAX1_HUMAN
NC score	0.015036 (rank : 71)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	355	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SQQ9, Q6ZSX0	Gene names	VAX1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

BAG3_HUMAN
NC score	0.014535 (rank : 72)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

VAX1_MOUSE
NC score	0.013211 (rank : 73)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	351	Shared Neighborhood Hits	8
SwissProt Accessions	Q2NKI2, O88880	Gene names	Vax1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

RFIP1_MOUSE
NC score	0.012310 (rank : 74)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	152	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

DMRT1_HUMAN
NC score	0.011650 (rank : 75)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5R6, Q8IW77	Gene names	DMRT1, DMT1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1).

WNK4_HUMAN
NC score	0.009800 (rank : 76)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	1043	Shared Neighborhood Hits	22
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

SF3B4_HUMAN
NC score	0.009113 (rank : 77)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

CUTL1_MOUSE
NC score	0.008902 (rank : 78)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	1620	Shared Neighborhood Hits	31
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

PGCA_HUMAN
NC score	0.008175 (rank : 79)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	821	Shared Neighborhood Hits	16
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

KCNH3_MOUSE
NC score	0.007645 (rank : 80)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	133	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

APS_HUMAN
NC score	0.007630 (rank : 81)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NDF4_MOUSE
NC score	0.007414 (rank : 82)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

FOXC1_HUMAN
NC score	0.007351 (rank : 83)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	208	Shared Neighborhood Hits	11
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

FOXC1_MOUSE
NC score	0.006619 (rank : 84)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

3BP1_MOUSE
NC score	0.006007 (rank : 85)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	6
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

WNK2_HUMAN
NC score	0.005814 (rank : 86)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	1407	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

EHMT2_MOUSE
NC score	0.005733 (rank : 87)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	750	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

PCDH1_HUMAN
NC score	0.005660 (rank : 88)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q08174	Gene names	PCDH1
Domain Architecture
Description	Protocadherin-1 precursor (Protocadherin-42) (PC42) (Cadherin-like protein 1).

NED4L_HUMAN
NC score	0.005325 (rank : 89)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

MARK3_HUMAN
NC score	0.004824 (rank : 90)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	893	Shared Neighborhood Hits	11
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

LTB1L_MOUSE
NC score	0.004709 (rank : 91)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	514	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

M3K9_HUMAN
NC score	0.004368 (rank : 92)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	1123	Shared Neighborhood Hits	16
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MARK3_MOUSE
NC score	0.004368 (rank : 93)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	919	Shared Neighborhood Hits	12
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

M4K4_MOUSE
NC score	-0.000268 (rank : 94)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	1560	Shared Neighborhood Hits	16
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).