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Network neighborhood for query Sequence : FRM4A_HUMAN

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FRM4A_HUMAN
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FRM4A_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	110	Target Neighborhood Hits	110	Shared Neighborhood Hits	110
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_MOUSE
θ value	0 (rank : 2)	NC score	0.998472 (rank : 2)
Query Neighborhood Hits	110	Target Neighborhood Hits	108	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
θ value	0 (rank : 3)	NC score	0.981749 (rank : 3)
Query Neighborhood Hits	110	Target Neighborhood Hits	117	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
θ value	0 (rank : 4)	NC score	0.981184 (rank : 4)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	54
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

RADI_HUMAN
θ value	1.12514e-34 (rank : 5)	NC score	0.712851 (rank : 26)
Query Neighborhood Hits	110	Target Neighborhood Hits	741	Shared Neighborhood Hits	59
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	1.12514e-34 (rank : 6)	NC score	0.709541 (rank : 27)
Query Neighborhood Hits	110	Target Neighborhood Hits	773	Shared Neighborhood Hits	61
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

MOES_HUMAN
θ value	1.46948e-34 (rank : 7)	NC score	0.671513 (rank : 30)
Query Neighborhood Hits	110	Target Neighborhood Hits	892	Shared Neighborhood Hits	64
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	7.29293e-34 (rank : 8)	NC score	0.663124 (rank : 31)
Query Neighborhood Hits	110	Target Neighborhood Hits	923	Shared Neighborhood Hits	64
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CA106_HUMAN
θ value	4.72714e-33 (rank : 9)	NC score	0.479261 (rank : 42)
Query Neighborhood Hits	110	Target Neighborhood Hits	124	Shared Neighborhood Hits	7
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

EZRI_MOUSE
θ value	8.06329e-33 (rank : 10)	NC score	0.724190 (rank : 25)
Query Neighborhood Hits	110	Target Neighborhood Hits	693	Shared Neighborhood Hits	60
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_HUMAN
θ value	5.22648e-32 (rank : 11)	NC score	0.727589 (rank : 24)
Query Neighborhood Hits	110	Target Neighborhood Hits	663	Shared Neighborhood Hits	60
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MERL_HUMAN
θ value	1.16434e-31 (rank : 12)	NC score	0.759674 (rank : 19)
Query Neighborhood Hits	110	Target Neighborhood Hits	532	Shared Neighborhood Hits	59
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	4.42448e-31 (rank : 13)	NC score	0.759545 (rank : 20)
Query Neighborhood Hits	110	Target Neighborhood Hits	524	Shared Neighborhood Hits	60
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

CA106_MOUSE
θ value	3.74554e-30 (rank : 14)	NC score	0.475202 (rank : 43)
Query Neighborhood Hits	110	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

E41L5_HUMAN
θ value	1.37858e-24 (rank : 15)	NC score	0.803744 (rank : 9)
Query Neighborhood Hits	110	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

FRMD5_HUMAN
θ value	8.93572e-24 (rank : 16)	NC score	0.810581 (rank : 6)
Query Neighborhood Hits	110	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	2.59989e-23 (rank : 17)	NC score	0.810832 (rank : 5)
Query Neighborhood Hits	110	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_HUMAN
θ value	7.56453e-23 (rank : 18)	NC score	0.778024 (rank : 13)
Query Neighborhood Hits	110	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41LA_HUMAN
θ value	7.56453e-23 (rank : 19)	NC score	0.804877 (rank : 7)
Query Neighborhood Hits	110	Target Neighborhood Hits	87	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	7.56453e-23 (rank : 20)	NC score	0.804510 (rank : 8)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L1_MOUSE
θ value	1.6852e-22 (rank : 21)	NC score	0.781780 (rank : 12)
Query Neighborhood Hits	110	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

PTN21_MOUSE
θ value	1.09232e-21 (rank : 22)	NC score	0.556769 (rank : 37)
Query Neighborhood Hits	110	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

FARP1_HUMAN
θ value	4.15078e-21 (rank : 23)	NC score	0.660479 (rank : 32)
Query Neighborhood Hits	110	Target Neighborhood Hits	241	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

E41LB_MOUSE
θ value	1.2077e-20 (rank : 24)	NC score	0.795793 (rank : 10)
Query Neighborhood Hits	110	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

PTN21_HUMAN
θ value	2.06002e-20 (rank : 25)	NC score	0.553426 (rank : 38)
Query Neighborhood Hits	110	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

FARP2_HUMAN
θ value	3.51386e-20 (rank : 26)	NC score	0.642894 (rank : 33)
Query Neighborhood Hits	110	Target Neighborhood Hits	240	Shared Neighborhood Hits	46
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

E41LB_HUMAN
θ value	4.58923e-20 (rank : 27)	NC score	0.787557 (rank : 11)
Query Neighborhood Hits	110	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

FARP2_MOUSE
θ value	1.02238e-19 (rank : 28)	NC score	0.632588 (rank : 34)
Query Neighborhood Hits	110	Target Neighborhood Hits	209	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

E41L3_HUMAN
θ value	1.74391e-19 (rank : 29)	NC score	0.777230 (rank : 14)
Query Neighborhood Hits	110	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

PTN13_MOUSE
θ value	1.74391e-19 (rank : 30)	NC score	0.450834 (rank : 44)
Query Neighborhood Hits	110	Target Neighborhood Hits	426	Shared Neighborhood Hits	54
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN14_HUMAN
θ value	2.27762e-19 (rank : 31)	NC score	0.538186 (rank : 41)
Query Neighborhood Hits	110	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
θ value	2.27762e-19 (rank : 32)	NC score	0.544584 (rank : 40)
Query Neighborhood Hits	110	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

E41L3_MOUSE
θ value	2.97466e-19 (rank : 33)	NC score	0.763638 (rank : 16)
Query Neighborhood Hits	110	Target Neighborhood Hits	250	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L2_HUMAN
θ value	3.88503e-19 (rank : 34)	NC score	0.760621 (rank : 18)
Query Neighborhood Hits	110	Target Neighborhood Hits	287	Shared Neighborhood Hits	57
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

PTN4_HUMAN
θ value	3.88503e-19 (rank : 35)	NC score	0.558314 (rank : 36)
Query Neighborhood Hits	110	Target Neighborhood Hits	303	Shared Neighborhood Hits	51
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN13_HUMAN
θ value	1.13037e-18 (rank : 36)	NC score	0.441566 (rank : 45)
Query Neighborhood Hits	110	Target Neighborhood Hits	471	Shared Neighborhood Hits	52
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

41_HUMAN
θ value	1.47631e-18 (rank : 37)	NC score	0.769396 (rank : 15)
Query Neighborhood Hits	110	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L2_MOUSE
θ value	1.24977e-17 (rank : 38)	NC score	0.738831 (rank : 22)
Query Neighborhood Hits	110	Target Neighborhood Hits	459	Shared Neighborhood Hits	54
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

41_MOUSE
θ value	4.74913e-17 (rank : 39)	NC score	0.763612 (rank : 17)
Query Neighborhood Hits	110	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

PTN3_HUMAN
θ value	4.74913e-17 (rank : 40)	NC score	0.547302 (rank : 39)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	50
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

MYLIP_MOUSE
θ value	8.38298e-14 (rank : 41)	NC score	0.751439 (rank : 21)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
θ value	1.86753e-13 (rank : 42)	NC score	0.734696 (rank : 23)
Query Neighborhood Hits	110	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

FRMD6_HUMAN
θ value	2.0648e-12 (rank : 43)	NC score	0.683559 (rank : 28)
Query Neighborhood Hits	110	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
θ value	1.9326e-10 (rank : 44)	NC score	0.677833 (rank : 29)
Query Neighborhood Hits	110	Target Neighborhood Hits	63	Shared Neighborhood Hits	43
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

TLN2_MOUSE
θ value	0.000121331 (rank : 45)	NC score	0.371338 (rank : 46)
Query Neighborhood Hits	110	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN2_HUMAN
θ value	0.00020696 (rank : 46)	NC score	0.365201 (rank : 48)
Query Neighborhood Hits	110	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

MYO10_HUMAN
θ value	0.000270298 (rank : 47)	NC score	0.058442 (rank : 105)
Query Neighborhood Hits	110	Target Neighborhood Hits	920	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TLN1_HUMAN
θ value	0.00035302 (rank : 48)	NC score	0.367096 (rank : 47)
Query Neighborhood Hits	110	Target Neighborhood Hits	218	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	0.00035302 (rank : 49)	NC score	0.364651 (rank : 49)
Query Neighborhood Hits	110	Target Neighborhood Hits	213	Shared Neighborhood Hits	45
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

FRMD1_HUMAN
θ value	0.00175202 (rank : 50)	NC score	0.617569 (rank : 35)
Query Neighborhood Hits	110	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

ROCK2_HUMAN
θ value	0.0736092 (rank : 51)	NC score	0.019557 (rank : 142)
Query Neighborhood Hits	110	Target Neighborhood Hits	2073	Shared Neighborhood Hits	33
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MAST1_HUMAN
θ value	0.0961366 (rank : 52)	NC score	0.007677 (rank : 163)
Query Neighborhood Hits	110	Target Neighborhood Hits	1146	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0.125558 (rank : 53)	NC score	0.007205 (rank : 165)
Query Neighborhood Hits	110	Target Neighborhood Hits	1123	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

GOGB1_HUMAN
θ value	0.163984 (rank : 54)	NC score	0.041913 (rank : 124)
Query Neighborhood Hits	110	Target Neighborhood Hits	2297	Shared Neighborhood Hits	40
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ROCK2_MOUSE
θ value	0.163984 (rank : 55)	NC score	0.017759 (rank : 147)
Query Neighborhood Hits	110	Target Neighborhood Hits	2072	Shared Neighborhood Hits	34
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SP1_HUMAN
θ value	0.163984 (rank : 56)	NC score	0.000093 (rank : 176)
Query Neighborhood Hits	110	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

KRIT1_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.120005 (rank : 50)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	21
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

EXOC1_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.040511 (rank : 125)
Query Neighborhood Hits	110	Target Neighborhood Hits	183	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NV70, Q8WUE7, Q96T15, Q9NZE4	Gene names	EXOC1, SEC3, SEC3L1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

GOGA4_HUMAN
θ value	0.47712 (rank : 59)	NC score	0.045692 (rank : 121)
Query Neighborhood Hits	110	Target Neighborhood Hits	2034	Shared Neighborhood Hits	38
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PHF20_MOUSE
θ value	0.62314 (rank : 60)	NC score	0.036307 (rank : 127)
Query Neighborhood Hits	110	Target Neighborhood Hits	513	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

KIFC3_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.027809 (rank : 132)
Query Neighborhood Hits	110	Target Neighborhood Hits	619	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

PCGF4_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.022014 (rank : 139)
Query Neighborhood Hits	110	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

EXOC1_MOUSE
θ value	1.38821 (rank : 63)	NC score	0.034738 (rank : 129)
Query Neighborhood Hits	110	Target Neighborhood Hits	190	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R3S6	Gene names	Exoc1, Sec3, Sec3l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

CCD13_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.043256 (rank : 122)
Query Neighborhood Hits	110	Target Neighborhood Hits	721	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

GA2L1_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.019129 (rank : 143)
Query Neighborhood Hits	110	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

LEPR_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.026258 (rank : 135)
Query Neighborhood Hits	110	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

NIPBL_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.035727 (rank : 128)
Query Neighborhood Hits	110	Target Neighborhood Hits	1311	Shared Neighborhood Hits	30
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NPBL_MOUSE
θ value	1.81305 (rank : 68)	NC score	0.032977 (rank : 130)
Query Neighborhood Hits	110	Target Neighborhood Hits	1041	Shared Neighborhood Hits	22
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

NR5A2_MOUSE
θ value	1.81305 (rank : 69)	NC score	0.005085 (rank : 170)
Query Neighborhood Hits	110	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

TRI59_MOUSE
θ value	1.81305 (rank : 70)	NC score	0.015276 (rank : 152)
Query Neighborhood Hits	110	Target Neighborhood Hits	292	Shared Neighborhood Hits	11
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

VP13B_HUMAN
θ value	1.81305 (rank : 71)	NC score	0.025755 (rank : 137)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

CBR2_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.012484 (rank : 159)
Query Neighborhood Hits	110	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

CDC27_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.018621 (rank : 145)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

CENPE_HUMAN
θ value	2.36792 (rank : 74)	NC score	0.036523 (rank : 126)
Query Neighborhood Hits	110	Target Neighborhood Hits	2060	Shared Neighborhood Hits	40
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

KIFC3_MOUSE
θ value	2.36792 (rank : 75)	NC score	0.025759 (rank : 136)
Query Neighborhood Hits	110	Target Neighborhood Hits	571	Shared Neighborhood Hits	18
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KS6A4_MOUSE
θ value	2.36792 (rank : 76)	NC score	0.000523 (rank : 174)
Query Neighborhood Hits	110	Target Neighborhood Hits	866	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

ALEX_HUMAN
θ value	3.0926 (rank : 77)	NC score	0.014808 (rank : 155)
Query Neighborhood Hits	110	Target Neighborhood Hits	361	Shared Neighborhood Hits	6
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

CRTC1_MOUSE
θ value	3.0926 (rank : 78)	NC score	0.018624 (rank : 144)
Query Neighborhood Hits	110	Target Neighborhood Hits	230	Shared Neighborhood Hits	6
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

MTSS1_HUMAN
θ value	3.0926 (rank : 79)	NC score	0.027164 (rank : 133)
Query Neighborhood Hits	110	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

NCOA3_HUMAN
θ value	3.0926 (rank : 80)	NC score	0.008148 (rank : 162)
Query Neighborhood Hits	110	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PCGF4_HUMAN
θ value	3.0926 (rank : 81)	NC score	0.014489 (rank : 156)
Query Neighborhood Hits	110	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

PTPRD_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.061013 (rank : 102)
Query Neighborhood Hits	110	Target Neighborhood Hits	485	Shared Neighborhood Hits	14
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

ZIMP7_HUMAN
θ value	3.0926 (rank : 83)	NC score	0.007045 (rank : 166)
Query Neighborhood Hits	110	Target Neighborhood Hits	290	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

AKAP1_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.016730 (rank : 149)
Query Neighborhood Hits	110	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

ANK2_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.005960 (rank : 167)
Query Neighborhood Hits	110	Target Neighborhood Hits	1615	Shared Neighborhood Hits	24
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

GRAP1_MOUSE
θ value	4.03905 (rank : 86)	NC score	0.042369 (rank : 123)
Query Neighborhood Hits	110	Target Neighborhood Hits	1234	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

IQGA1_HUMAN
θ value	4.03905 (rank : 87)	NC score	0.016993 (rank : 148)
Query Neighborhood Hits	110	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

IQGA1_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.020224 (rank : 141)
Query Neighborhood Hits	110	Target Neighborhood Hits	219	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

MARK2_MOUSE
θ value	4.03905 (rank : 89)	NC score	0.000122 (rank : 175)
Query Neighborhood Hits	110	Target Neighborhood Hits	1018	Shared Neighborhood Hits	12
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MBTP1_MOUSE
θ value	4.03905 (rank : 90)	NC score	0.010750 (rank : 160)
Query Neighborhood Hits	110	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

BIG1_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.005143 (rank : 168)
Query Neighborhood Hits	110	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CJ012_HUMAN
θ value	5.27518 (rank : 92)	NC score	0.013803 (rank : 158)
Query Neighborhood Hits	110	Target Neighborhood Hits	467	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

GRAP1_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.023976 (rank : 138)
Query Neighborhood Hits	110	Target Neighborhood Hits	944	Shared Neighborhood Hits	26
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

NCOA7_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.020498 (rank : 140)
Query Neighborhood Hits	110	Target Neighborhood Hits	160	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NI08, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4	Gene names	NCOA7, ERAP140, ESNA1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1).

STC2_HUMAN
θ value	5.27518 (rank : 95)	NC score	0.009859 (rank : 161)
Query Neighborhood Hits	110	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	O76061	Gene names	STC2
Domain Architecture
Description	Stanniocalcin-2 precursor (STC-2) (Stanniocalcin-related protein) (STCRP) (STC-related protein).

TARA_MOUSE
θ value	5.27518 (rank : 96)	NC score	0.026690 (rank : 134)
Query Neighborhood Hits	110	Target Neighborhood Hits	1133	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CF072_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.016350 (rank : 150)
Query Neighborhood Hits	110	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NU53	Gene names	C6orf72
Domain Architecture	No domain graphic available
Description	Protein C6orf72 precursor.

DYH9_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.007343 (rank : 164)
Query Neighborhood Hits	110	Target Neighborhood Hits	291	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

FSBP_MOUSE
θ value	6.88961 (rank : 99)	NC score	0.017970 (rank : 146)
Query Neighborhood Hits	110	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKE5, Q8BJX8	Gene names	Fsbp
Domain Architecture	No domain graphic available
Description	Fibrinogen silencer-binding protein.

HNRPK_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.015112 (rank : 153)
Query Neighborhood Hits	110	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
θ value	6.88961 (rank : 101)	NC score	0.015112 (rank : 154)
Query Neighborhood Hits	110	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

MTSS1_MOUSE
θ value	6.88961 (rank : 102)	NC score	0.016042 (rank : 151)
Query Neighborhood Hits	110	Target Neighborhood Hits	592	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MYO3A_MOUSE
θ value	6.88961 (rank : 103)	NC score	0.001451 (rank : 173)
Query Neighborhood Hits	110	Target Neighborhood Hits	902	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PTPRD_MOUSE
θ value	6.88961 (rank : 104)	NC score	0.058405 (rank : 106)
Query Neighborhood Hits	110	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SP1_MOUSE
θ value	6.88961 (rank : 105)	NC score	-0.002118 (rank : 177)
Query Neighborhood Hits	110	Target Neighborhood Hits	730	Shared Neighborhood Hits	3
SwissProt Accessions	O89090, O89087, Q62251, Q64167	Gene names	Sp1
Domain Architecture
Description	Transcription factor Sp1.

IL1R1_MOUSE
θ value	8.99809 (rank : 106)	NC score	0.004411 (rank : 171)
Query Neighborhood Hits	110	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

LEPR_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.014302 (rank : 157)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

NR5A2_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.003022 (rank : 172)
Query Neighborhood Hits	110	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

PARD3_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.031206 (rank : 131)
Query Neighborhood Hits	110	Target Neighborhood Hits	290	Shared Neighborhood Hits	12
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

TISD_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.005112 (rank : 169)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

CCD11_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.055294 (rank : 112)
Query Neighborhood Hits	110	Target Neighborhood Hits	822	Shared Neighborhood Hits	19
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD50_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.057139 (rank : 110)
Query Neighborhood Hits	110	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

CD45_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.087767 (rank : 86)
Query Neighborhood Hits	110	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CD45_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.090795 (rank : 75)
Query Neighborhood Hits	110	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

CDC37_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.050807 (rank : 120)
Query Neighborhood Hits	110	Target Neighborhood Hits	506	Shared Neighborhood Hits	17
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CLCB_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.052227 (rank : 116)
Query Neighborhood Hits	110	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q6IRU5, Q8BR04, Q8CDX9, Q9CV35	Gene names	Cltb
Domain Architecture	No domain graphic available
Description	Clathrin light chain B (Lcb).

CT2NL_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.055149 (rank : 113)
Query Neighborhood Hits	110	Target Neighborhood Hits	1059	Shared Neighborhood Hits	24
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.054867 (rank : 114)
Query Neighborhood Hits	110	Target Neighborhood Hits	902	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

HIP1R_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.060919 (rank : 103)
Query Neighborhood Hits	110	Target Neighborhood Hits	809	Shared Neighborhood Hits	26
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HIP1R_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.057517 (rank : 109)
Query Neighborhood Hits	110	Target Neighborhood Hits	959	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

HIP1_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.061276 (rank : 101)
Query Neighborhood Hits	110	Target Neighborhood Hits	1016	Shared Neighborhood Hits	28
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

KRIT1_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.099325 (rank : 59)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

NAF1_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.058043 (rank : 108)
Query Neighborhood Hits	110	Target Neighborhood Hits	937	Shared Neighborhood Hits	27
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NEB2_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.052098 (rank : 117)
Query Neighborhood Hits	110	Target Neighborhood Hits	883	Shared Neighborhood Hits	24
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PTN11_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.090304 (rank : 78)
Query Neighborhood Hits	110	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.090294 (rank : 79)
Query Neighborhood Hits	110	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.095905 (rank : 66)
Query Neighborhood Hits	110	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.095959 (rank : 65)
Query Neighborhood Hits	110	Target Neighborhood Hits	123	Shared Neighborhood Hits	12
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN18_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.103141 (rank : 54)
Query Neighborhood Hits	110	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.100030 (rank : 56)
Query Neighborhood Hits	110	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.103296 (rank : 53)
Query Neighborhood Hits	110	Target Neighborhood Hits	84	Shared Neighborhood Hits	10
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.103593 (rank : 52)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.097172 (rank : 60)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.095731 (rank : 67)
Query Neighborhood Hits	110	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.089738 (rank : 81)
Query Neighborhood Hits	110	Target Neighborhood Hits	646	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN23_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.088563 (rank : 84)
Query Neighborhood Hits	110	Target Neighborhood Hits	726	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTN2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.103131 (rank : 55)
Query Neighborhood Hits	110	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.104270 (rank : 51)
Query Neighborhood Hits	110	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN5_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.090674 (rank : 76)
Query Neighborhood Hits	110	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.090549 (rank : 77)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.096063 (rank : 63)
Query Neighborhood Hits	110	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.095991 (rank : 64)
Query Neighborhood Hits	110	Target Neighborhood Hits	225	Shared Neighborhood Hits	10
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.096196 (rank : 62)
Query Neighborhood Hits	110	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.097144 (rank : 61)
Query Neighborhood Hits	110	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.099965 (rank : 57)
Query Neighborhood Hits	110	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.099647 (rank : 58)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.092581 (rank : 72)
Query Neighborhood Hits	110	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.092772 (rank : 71)
Query Neighborhood Hits	110	Target Neighborhood Hits	120	Shared Neighborhood Hits	11
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.084645 (rank : 88)
Query Neighborhood Hits	110	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.084379 (rank : 90)
Query Neighborhood Hits	110	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRB_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.088080 (rank : 85)
Query Neighborhood Hits	110	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

PTPRE_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.084807 (rank : 87)
Query Neighborhood Hits	110	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.084449 (rank : 89)
Query Neighborhood Hits	110	Target Neighborhood Hits	86	Shared Neighborhood Hits	10
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRF_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.058119 (rank : 107)
Query Neighborhood Hits	110	Target Neighborhood Hits	489	Shared Neighborhood Hits	13
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRG_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.074959 (rank : 94)
Query Neighborhood Hits	110	Target Neighborhood Hits	231	Shared Neighborhood Hits	13
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.074949 (rank : 95)
Query Neighborhood Hits	110	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRJ_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.089722 (rank : 82)
Query Neighborhood Hits	110	Target Neighborhood Hits	207	Shared Neighborhood Hits	11
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.089999 (rank : 80)
Query Neighborhood Hits	110	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTPRK_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.075691 (rank : 92)
Query Neighborhood Hits	110	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.076346 (rank : 91)
Query Neighborhood Hits	110	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRM_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.071296 (rank : 99)
Query Neighborhood Hits	110	Target Neighborhood Hits	244	Shared Neighborhood Hits	10
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.071652 (rank : 98)
Query Neighborhood Hits	110	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRN_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.093212 (rank : 69)
Query Neighborhood Hits	110	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.093062 (rank : 70)
Query Neighborhood Hits	110	Target Neighborhood Hits	240	Shared Neighborhood Hits	12
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRO_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.093715 (rank : 68)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.092133 (rank : 74)
Query Neighborhood Hits	110	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.092402 (rank : 73)
Query Neighborhood Hits	110	Target Neighborhood Hits	84	Shared Neighborhood Hits	10
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRS_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.060652 (rank : 104)
Query Neighborhood Hits	110	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PTPRT_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.073355 (rank : 96)
Query Neighborhood Hits	110	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.073270 (rank : 97)
Query Neighborhood Hits	110	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRU_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.071230 (rank : 100)
Query Neighborhood Hits	110	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRV_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.089453 (rank : 83)
Query Neighborhood Hits	110	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.075469 (rank : 93)
Query Neighborhood Hits	110	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RIMB1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.051565 (rank : 118)
Query Neighborhood Hits	110	Target Neighborhood Hits	1376	Shared Neighborhood Hits	26
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPC24_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.055394 (rank : 111)
Query Neighborhood Hits	110	Target Neighborhood Hits	324	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

STXB4_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.051164 (rank : 119)
Query Neighborhood Hits	110	Target Neighborhood Hits	616	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TPM4_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.054490 (rank : 115)
Query Neighborhood Hits	110	Target Neighborhood Hits	703	Shared Neighborhood Hits	23
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

Hits sorted by NC score

FRM4A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	110	Target Neighborhood Hits	110	Shared Neighborhood Hits	110
SwissProt Accessions	Q9P2Q2	Gene names	FRMD4A, FRMD4, KIAA1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4A_MOUSE
NC score	0.998472 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	110	Target Neighborhood Hits	108	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BIE6, Q6PDJ4, Q8CHA6	Gene names	Frmd4a, Frmd4, Kiaa1294
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4A.

FRM4B_HUMAN
NC score	0.981749 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	110	Target Neighborhood Hits	117	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

FRM4B_MOUSE
NC score	0.981184 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	54
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

FRMD5_MOUSE
NC score	0.810832 (rank : 5)	θ value	2.59989e-23 (rank : 17)
Query Neighborhood Hits	110	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_HUMAN
NC score	0.810581 (rank : 6)	θ value	8.93572e-24 (rank : 16)
Query Neighborhood Hits	110	Target Neighborhood Hits	55	Shared Neighborhood Hits	48
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41LA_HUMAN
NC score	0.804877 (rank : 7)	θ value	7.56453e-23 (rank : 19)
Query Neighborhood Hits	110	Target Neighborhood Hits	87	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
NC score	0.804510 (rank : 8)	θ value	7.56453e-23 (rank : 20)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41L5_HUMAN
NC score	0.803744 (rank : 9)	θ value	1.37858e-24 (rank : 15)
Query Neighborhood Hits	110	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.795793 (rank : 10)	θ value	1.2077e-20 (rank : 24)
Query Neighborhood Hits	110	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41LB_HUMAN
NC score	0.787557 (rank : 11)	θ value	4.58923e-20 (rank : 27)
Query Neighborhood Hits	110	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41L1_MOUSE
NC score	0.781780 (rank : 12)	θ value	1.6852e-22 (rank : 21)
Query Neighborhood Hits	110	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_HUMAN
NC score	0.778024 (rank : 13)	θ value	7.56453e-23 (rank : 18)
Query Neighborhood Hits	110	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L3_HUMAN
NC score	0.777230 (rank : 14)	θ value	1.74391e-19 (rank : 29)
Query Neighborhood Hits	110	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

41_HUMAN
NC score	0.769396 (rank : 15)	θ value	1.47631e-18 (rank : 37)
Query Neighborhood Hits	110	Target Neighborhood Hits	157	Shared Neighborhood Hits	53
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L3_MOUSE
NC score	0.763638 (rank : 16)	θ value	2.97466e-19 (rank : 33)
Query Neighborhood Hits	110	Target Neighborhood Hits	250	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

41_MOUSE
NC score	0.763612 (rank : 17)	θ value	4.74913e-17 (rank : 39)
Query Neighborhood Hits	110	Target Neighborhood Hits	184	Shared Neighborhood Hits	52
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L2_HUMAN
NC score	0.760621 (rank : 18)	θ value	3.88503e-19 (rank : 34)
Query Neighborhood Hits	110	Target Neighborhood Hits	287	Shared Neighborhood Hits	57
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MERL_HUMAN
NC score	0.759674 (rank : 19)	θ value	1.16434e-31 (rank : 12)
Query Neighborhood Hits	110	Target Neighborhood Hits	532	Shared Neighborhood Hits	59
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
NC score	0.759545 (rank : 20)	θ value	4.42448e-31 (rank : 13)
Query Neighborhood Hits	110	Target Neighborhood Hits	524	Shared Neighborhood Hits	60
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MYLIP_MOUSE
NC score	0.751439 (rank : 21)	θ value	8.38298e-14 (rank : 41)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

E41L2_MOUSE
NC score	0.738831 (rank : 22)	θ value	1.24977e-17 (rank : 38)
Query Neighborhood Hits	110	Target Neighborhood Hits	459	Shared Neighborhood Hits	54
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MYLIP_HUMAN
NC score	0.734696 (rank : 23)	θ value	1.86753e-13 (rank : 42)
Query Neighborhood Hits	110	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

EZRI_HUMAN
NC score	0.727589 (rank : 24)	θ value	5.22648e-32 (rank : 11)
Query Neighborhood Hits	110	Target Neighborhood Hits	663	Shared Neighborhood Hits	60
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
NC score	0.724190 (rank : 25)	θ value	8.06329e-33 (rank : 10)
Query Neighborhood Hits	110	Target Neighborhood Hits	693	Shared Neighborhood Hits	60
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RADI_HUMAN
NC score	0.712851 (rank : 26)	θ value	1.12514e-34 (rank : 5)
Query Neighborhood Hits	110	Target Neighborhood Hits	741	Shared Neighborhood Hits	59
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
NC score	0.709541 (rank : 27)	θ value	1.12514e-34 (rank : 6)
Query Neighborhood Hits	110	Target Neighborhood Hits	773	Shared Neighborhood Hits	61
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

FRMD6_HUMAN
NC score	0.683559 (rank : 28)	θ value	2.0648e-12 (rank : 43)
Query Neighborhood Hits	110	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q96NE9, Q5HYF2, Q8N2X1, Q8WUH7	Gene names	FRMD6, C14orf31
Domain Architecture
Description	FERM domain-containing protein 6 (Willin).

FRMD6_MOUSE
NC score	0.677833 (rank : 29)	θ value	1.9326e-10 (rank : 44)
Query Neighborhood Hits	110	Target Neighborhood Hits	63	Shared Neighborhood Hits	43
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

MOES_HUMAN
NC score	0.671513 (rank : 30)	θ value	1.46948e-34 (rank : 7)
Query Neighborhood Hits	110	Target Neighborhood Hits	892	Shared Neighborhood Hits	64
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
NC score	0.663124 (rank : 31)	θ value	7.29293e-34 (rank : 8)
Query Neighborhood Hits	110	Target Neighborhood Hits	923	Shared Neighborhood Hits	64
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FARP1_HUMAN
NC score	0.660479 (rank : 32)	θ value	4.15078e-21 (rank : 23)
Query Neighborhood Hits	110	Target Neighborhood Hits	241	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
NC score	0.642894 (rank : 33)	θ value	3.51386e-20 (rank : 26)
Query Neighborhood Hits	110	Target Neighborhood Hits	240	Shared Neighborhood Hits	46
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.632588 (rank : 34)	θ value	1.02238e-19 (rank : 28)
Query Neighborhood Hits	110	Target Neighborhood Hits	209	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FRMD1_HUMAN
NC score	0.617569 (rank : 35)	θ value	0.00175202 (rank : 50)
Query Neighborhood Hits	110	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N878, Q5SZU7, Q9UFB0	Gene names	FRMD1
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 1.

PTN4_HUMAN
NC score	0.558314 (rank : 36)	θ value	3.88503e-19 (rank : 35)
Query Neighborhood Hits	110	Target Neighborhood Hits	303	Shared Neighborhood Hits	51
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN21_MOUSE
NC score	0.556769 (rank : 37)	θ value	1.09232e-21 (rank : 22)
Query Neighborhood Hits	110	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN21_HUMAN
NC score	0.553426 (rank : 38)	θ value	2.06002e-20 (rank : 25)
Query Neighborhood Hits	110	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN3_HUMAN
NC score	0.547302 (rank : 39)	θ value	4.74913e-17 (rank : 40)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	50
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN14_MOUSE
NC score	0.544584 (rank : 40)	θ value	2.27762e-19 (rank : 32)
Query Neighborhood Hits	110	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN14_HUMAN
NC score	0.538186 (rank : 41)	θ value	2.27762e-19 (rank : 31)
Query Neighborhood Hits	110	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

CA106_HUMAN
NC score	0.479261 (rank : 42)	θ value	4.72714e-33 (rank : 9)
Query Neighborhood Hits	110	Target Neighborhood Hits	124	Shared Neighborhood Hits	7
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CA106_MOUSE
NC score	0.475202 (rank : 43)	θ value	3.74554e-30 (rank : 14)
Query Neighborhood Hits	110	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

PTN13_MOUSE
NC score	0.450834 (rank : 44)	θ value	1.74391e-19 (rank : 30)
Query Neighborhood Hits	110	Target Neighborhood Hits	426	Shared Neighborhood Hits	54
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.441566 (rank : 45)	θ value	1.13037e-18 (rank : 36)
Query Neighborhood Hits	110	Target Neighborhood Hits	471	Shared Neighborhood Hits	52
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TLN2_MOUSE
NC score	0.371338 (rank : 46)	θ value	0.000121331 (rank : 45)
Query Neighborhood Hits	110	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q71LX4, Q8BWK0	Gene names	Tln2
Domain Architecture	No domain graphic available
Description	Talin-2.

TLN1_HUMAN
NC score	0.367096 (rank : 47)	θ value	0.00035302 (rank : 48)
Query Neighborhood Hits	110	Target Neighborhood Hits	218	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN2_HUMAN
NC score	0.365201 (rank : 48)	θ value	0.00020696 (rank : 46)
Query Neighborhood Hits	110	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

TLN1_MOUSE
NC score	0.364651 (rank : 49)	θ value	0.00035302 (rank : 49)
Query Neighborhood Hits	110	Target Neighborhood Hits	213	Shared Neighborhood Hits	45
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

KRIT1_HUMAN
NC score	0.120005 (rank : 50)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	21
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

PTN2_MOUSE
NC score	0.104270 (rank : 51)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	110	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN1_MOUSE
NC score	0.103593 (rank : 52)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN1_HUMAN
NC score	0.103296 (rank : 53)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	110	Target Neighborhood Hits	84	Shared Neighborhood Hits	10
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN18_HUMAN
NC score	0.103141 (rank : 54)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	110	Target Neighborhood Hits	73	Shared Neighborhood Hits	10
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN2_HUMAN
NC score	0.103131 (rank : 55)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	110	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN18_MOUSE
NC score	0.100030 (rank : 56)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	110	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN9_HUMAN
NC score	0.099965 (rank : 57)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	110	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
NC score	0.099647 (rank : 58)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	10
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

KRIT1_MOUSE
NC score	0.099325 (rank : 59)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	110	Target Neighborhood Hits	258	Shared Neighborhood Hits	23
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

PTN22_HUMAN
NC score	0.097172 (rank : 60)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN7_MOUSE
NC score	0.097144 (rank : 61)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	110	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN7_HUMAN
NC score	0.096196 (rank : 62)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	110	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN6_HUMAN
NC score	0.096063 (rank : 63)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	110	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
NC score	0.095991 (rank : 64)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	110	Target Neighborhood Hits	225	Shared Neighborhood Hits	10
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN12_MOUSE
NC score	0.095959 (rank : 65)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	110	Target Neighborhood Hits	123	Shared Neighborhood Hits	12
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN12_HUMAN
NC score	0.095905 (rank : 66)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	110	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN22_MOUSE
NC score	0.095731 (rank : 67)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	110	Target Neighborhood Hits	179	Shared Neighborhood Hits	10
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTPRO_HUMAN
NC score	0.093715 (rank : 68)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

PTPRN_HUMAN
NC score	0.093212 (rank : 69)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	110	Target Neighborhood Hits	156	Shared Neighborhood Hits	12
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
NC score	0.093062 (rank : 70)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	110	Target Neighborhood Hits	240	Shared Neighborhood Hits	12
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPR2_MOUSE
NC score	0.092772 (rank : 71)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	110	Target Neighborhood Hits	120	Shared Neighborhood Hits	11
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPR2_HUMAN
NC score	0.092581 (rank : 72)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	110	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPRR_MOUSE
NC score	0.092402 (rank : 73)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	110	Target Neighborhood Hits	84	Shared Neighborhood Hits	10
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRR_HUMAN
NC score	0.092133 (rank : 74)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	110	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

CD45_MOUSE
NC score	0.090795 (rank : 75)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	110	Target Neighborhood Hits	178	Shared Neighborhood Hits	15
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

PTN5_HUMAN
NC score	0.090674 (rank : 76)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	110	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
NC score	0.090549 (rank : 77)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	110	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN11_HUMAN
NC score	0.090304 (rank : 78)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	110	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
NC score	0.090294 (rank : 79)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	110	Target Neighborhood Hits	227	Shared Neighborhood Hits	11
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTPRJ_MOUSE
NC score	0.089999 (rank : 80)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	110	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PTN23_HUMAN
NC score	0.089738 (rank : 81)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	110	Target Neighborhood Hits	646	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTPRJ_HUMAN
NC score	0.089722 (rank : 82)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	110	Target Neighborhood Hits	207	Shared Neighborhood Hits	11
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRV_MOUSE
NC score	0.089453 (rank : 83)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	110	Target Neighborhood Hits	179	Shared Neighborhood Hits	11
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

PTN23_MOUSE
NC score	0.088563 (rank : 84)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	110	Target Neighborhood Hits	726	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTPRB_HUMAN
NC score	0.088080 (rank : 85)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	110	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

CD45_HUMAN
NC score	0.087767 (rank : 86)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	110	Target Neighborhood Hits	243	Shared Neighborhood Hits	11
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

PTPRE_HUMAN
NC score	0.084807 (rank : 87)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	110	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
NC score	0.084645 (rank : 88)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	110	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_MOUSE
NC score	0.084449 (rank : 89)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	110	Target Neighborhood Hits	86	Shared Neighborhood Hits	10
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_MOUSE
NC score	0.084379 (rank : 90)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	110	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRK_MOUSE
NC score	0.076346 (rank : 91)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	110	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_HUMAN
NC score	0.075691 (rank : 92)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	110	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRZ_HUMAN
NC score	0.075469 (rank : 93)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	110	Target Neighborhood Hits	255	Shared Neighborhood Hits	11
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PTPRG_HUMAN
NC score	0.074959 (rank : 94)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	110	Target Neighborhood Hits	231	Shared Neighborhood Hits	13
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
NC score	0.074949 (rank : 95)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	110	Target Neighborhood Hits	260	Shared Neighborhood Hits	12
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRT_HUMAN
NC score	0.073355 (rank : 96)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	110	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.073270 (rank : 97)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	110	Target Neighborhood Hits	219	Shared Neighborhood Hits	10
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PTPRM_MOUSE
NC score	0.071652 (rank : 98)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	110	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_HUMAN
NC score	0.071296 (rank : 99)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	110	Target Neighborhood Hits	244	Shared Neighborhood Hits	10
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRU_HUMAN
NC score	0.071230 (rank : 100)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	110	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

HIP1_HUMAN
NC score	0.061276 (rank : 101)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	110	Target Neighborhood Hits	1016	Shared Neighborhood Hits	28
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

PTPRD_HUMAN
NC score	0.061013 (rank : 102)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	110	Target Neighborhood Hits	485	Shared Neighborhood Hits	14
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

HIP1R_HUMAN
NC score	0.060919 (rank : 103)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	110	Target Neighborhood Hits	809	Shared Neighborhood Hits	26
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

PTPRS_HUMAN
NC score	0.060652 (rank : 104)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	110	Target Neighborhood Hits	472	Shared Neighborhood Hits	11
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

MYO10_HUMAN
NC score	0.058442 (rank : 105)	θ value	0.000270298 (rank : 47)
Query Neighborhood Hits	110	Target Neighborhood Hits	920	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PTPRD_MOUSE
NC score	0.058405 (rank : 106)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	110	Target Neighborhood Hits	491	Shared Neighborhood Hits	12
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
NC score	0.058119 (rank : 107)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	110	Target Neighborhood Hits	489	Shared Neighborhood Hits	13
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

NAF1_HUMAN
NC score	0.058043 (rank : 108)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	110	Target Neighborhood Hits	937	Shared Neighborhood Hits	27
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

HIP1R_MOUSE
NC score	0.057517 (rank : 109)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	110	Target Neighborhood Hits	959	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

CCD50_HUMAN
NC score	0.057139 (rank : 110)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	110	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IVM0, Q86VH7	Gene names	CCDC50, C3orf6
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

SPC24_HUMAN
NC score	0.055394 (rank : 111)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	110	Target Neighborhood Hits	324	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

CCD11_HUMAN
NC score	0.055294 (rank : 112)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	110	Target Neighborhood Hits	822	Shared Neighborhood Hits	19
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CT2NL_HUMAN
NC score	0.055149 (rank : 113)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	110	Target Neighborhood Hits	1059	Shared Neighborhood Hits	24
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
NC score	0.054867 (rank : 114)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	110	Target Neighborhood Hits	902	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

TPM4_MOUSE
NC score	0.054490 (rank : 115)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	110	Target Neighborhood Hits	703	Shared Neighborhood Hits	23
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

CLCB_MOUSE
NC score	0.052227 (rank : 116)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	110	Target Neighborhood Hits	119	Shared Neighborhood Hits	10
SwissProt Accessions	Q6IRU5, Q8BR04, Q8CDX9, Q9CV35	Gene names	Cltb
Domain Architecture	No domain graphic available
Description	Clathrin light chain B (Lcb).

NEB2_HUMAN
NC score	0.052098 (rank : 117)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	110	Target Neighborhood Hits	883	Shared Neighborhood Hits	24
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

RIMB1_MOUSE
NC score	0.051565 (rank : 118)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	110	Target Neighborhood Hits	1376	Shared Neighborhood Hits	26
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

STXB4_HUMAN
NC score	0.051164 (rank : 119)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	110	Target Neighborhood Hits	616	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

CDC37_HUMAN
NC score	0.050807 (rank : 120)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	110	Target Neighborhood Hits	506	Shared Neighborhood Hits	17
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

GOGA4_HUMAN
NC score	0.045692 (rank : 121)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	110	Target Neighborhood Hits	2034	Shared Neighborhood Hits	38
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CCD13_HUMAN
NC score	0.043256 (rank : 122)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	110	Target Neighborhood Hits	721	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

GRAP1_MOUSE
NC score	0.042369 (rank : 123)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	110	Target Neighborhood Hits	1234	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GOGB1_HUMAN
NC score	0.041913 (rank : 124)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	110	Target Neighborhood Hits	2297	Shared Neighborhood Hits	40
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

EXOC1_HUMAN
NC score	0.040511 (rank : 125)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	110	Target Neighborhood Hits	183	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NV70, Q8WUE7, Q96T15, Q9NZE4	Gene names	EXOC1, SEC3, SEC3L1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

CENPE_HUMAN
NC score	0.036523 (rank : 126)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	110	Target Neighborhood Hits	2060	Shared Neighborhood Hits	40
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

PHF20_MOUSE
NC score	0.036307 (rank : 127)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	110	Target Neighborhood Hits	513	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

NIPBL_HUMAN
NC score	0.035727 (rank : 128)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	110	Target Neighborhood Hits	1311	Shared Neighborhood Hits	30
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

EXOC1_MOUSE
NC score	0.034738 (rank : 129)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	110	Target Neighborhood Hits	190	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R3S6	Gene names	Exoc1, Sec3, Sec3l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 1 (Exocyst complex component Sec3).

NPBL_MOUSE
NC score	0.032977 (rank : 130)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	110	Target Neighborhood Hits	1041	Shared Neighborhood Hits	22
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PARD3_MOUSE
NC score	0.031206 (rank : 131)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	110	Target Neighborhood Hits	290	Shared Neighborhood Hits	12
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

KIFC3_HUMAN
NC score	0.027809 (rank : 132)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	110	Target Neighborhood Hits	619	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

MTSS1_HUMAN
NC score	0.027164 (rank : 133)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	110	Target Neighborhood Hits	504	Shared Neighborhood Hits	13
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

TARA_MOUSE
NC score	0.026690 (rank : 134)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	110	Target Neighborhood Hits	1133	Shared Neighborhood Hits	26
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

LEPR_HUMAN
NC score	0.026258 (rank : 135)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	110	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

KIFC3_MOUSE
NC score	0.025759 (rank : 136)	θ value	2.36792 (rank : 75)
Query Neighborhood Hits	110	Target Neighborhood Hits	571	Shared Neighborhood Hits	18
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

VP13B_HUMAN
NC score	0.025755 (rank : 137)	θ value	1.81305 (rank : 71)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

GRAP1_HUMAN
NC score	0.023976 (rank : 138)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	110	Target Neighborhood Hits	944	Shared Neighborhood Hits	26
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

PCGF4_MOUSE
NC score	0.022014 (rank : 139)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	110	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

NCOA7_HUMAN
NC score	0.020498 (rank : 140)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	110	Target Neighborhood Hits	160	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NI08, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4	Gene names	NCOA7, ERAP140, ESNA1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1).

IQGA1_MOUSE
NC score	0.020224 (rank : 141)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	110	Target Neighborhood Hits	219	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKF1	Gene names	Iqgap1
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1.

ROCK2_HUMAN
NC score	0.019557 (rank : 142)	θ value	0.0736092 (rank : 51)
Query Neighborhood Hits	110	Target Neighborhood Hits	2073	Shared Neighborhood Hits	33
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

GA2L1_HUMAN
NC score	0.019129 (rank : 143)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	110	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

CRTC1_MOUSE
NC score	0.018624 (rank : 144)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	110	Target Neighborhood Hits	230	Shared Neighborhood Hits	6
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

CDC27_HUMAN
NC score	0.018621 (rank : 145)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	110	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

FSBP_MOUSE
NC score	0.017970 (rank : 146)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	110	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKE5, Q8BJX8	Gene names	Fsbp
Domain Architecture	No domain graphic available
Description	Fibrinogen silencer-binding protein.

ROCK2_MOUSE
NC score	0.017759 (rank : 147)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	110	Target Neighborhood Hits	2072	Shared Neighborhood Hits	34
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

IQGA1_HUMAN
NC score	0.016993 (rank : 148)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	110	Target Neighborhood Hits	250	Shared Neighborhood Hits	11
SwissProt Accessions	P46940	Gene names	IQGAP1, KIAA0051
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP1 (p195).

AKAP1_HUMAN
NC score	0.016730 (rank : 149)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	110	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

CF072_HUMAN
NC score	0.016350 (rank : 150)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	110	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NU53	Gene names	C6orf72
Domain Architecture	No domain graphic available
Description	Protein C6orf72 precursor.

MTSS1_MOUSE
NC score	0.016042 (rank : 151)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	110	Target Neighborhood Hits	592	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

TRI59_MOUSE
NC score	0.015276 (rank : 152)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	110	Target Neighborhood Hits	292	Shared Neighborhood Hits	11
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

HNRPK_HUMAN
NC score	0.015112 (rank : 153)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	110	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
NC score	0.015112 (rank : 154)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	110	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

ALEX_HUMAN
NC score	0.014808 (rank : 155)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	110	Target Neighborhood Hits	361	Shared Neighborhood Hits	6
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PCGF4_HUMAN
NC score	0.014489 (rank : 156)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	110	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

LEPR_MOUSE
NC score	0.014302 (rank : 157)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	110	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

CJ012_HUMAN
NC score	0.013803 (rank : 158)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	110	Target Neighborhood Hits	467	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CBR2_MOUSE
NC score	0.012484 (rank : 159)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	110	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

MBTP1_MOUSE
NC score	0.010750 (rank : 160)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	110	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTZ2, Q6PG67	Gene names	Mbtps1, S1p, Ski1
Domain Architecture
Description	Membrane-bound transcription factor site 1 protease precursor (EC 3.4.21.-) (S1P endopeptidase) (Site-1 protease) (Subtilisin/kexin isozyme 1) (SKI-1) (Sterol-regulated luminal protease).

STC2_HUMAN
NC score	0.009859 (rank : 161)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	110	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	O76061	Gene names	STC2
Domain Architecture
Description	Stanniocalcin-2 precursor (STC-2) (Stanniocalcin-related protein) (STCRP) (STC-related protein).

NCOA3_HUMAN
NC score	0.008148 (rank : 162)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	110	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

MAST1_HUMAN
NC score	0.007677 (rank : 163)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	110	Target Neighborhood Hits	1146	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

DYH9_HUMAN
NC score	0.007343 (rank : 164)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	110	Target Neighborhood Hits	291	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

MAST1_MOUSE
NC score	0.007205 (rank : 165)	θ value	0.125558 (rank : 53)
Query Neighborhood Hits	110	Target Neighborhood Hits	1123	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ZIMP7_HUMAN
NC score	0.007045 (rank : 166)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	110	Target Neighborhood Hits	290	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ANK2_HUMAN
NC score	0.005960 (rank : 167)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	110	Target Neighborhood Hits	1615	Shared Neighborhood Hits	24
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

BIG1_HUMAN
NC score	0.005143 (rank : 168)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	110	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

TISD_HUMAN
NC score	0.005112 (rank : 169)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	110	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

NR5A2_MOUSE
NC score	0.005085 (rank : 170)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	110	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

IL1R1_MOUSE
NC score	0.004411 (rank : 171)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	110	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

NR5A2_HUMAN
NC score	0.003022 (rank : 172)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	110	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	O00482, O95642	Gene names	NR5A2, B1F, CPF, FTF
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Alpha-1-fetoprotein transcription factor) (Hepatocytic transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Liver receptor homolog 1) (LRH-1).

MYO3A_MOUSE
NC score	0.001451 (rank : 173)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	110	Target Neighborhood Hits	902	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

KS6A4_MOUSE
NC score	0.000523 (rank : 174)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	110	Target Neighborhood Hits	866	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MARK2_MOUSE
NC score	0.000122 (rank : 175)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	110	Target Neighborhood Hits	1018	Shared Neighborhood Hits	12
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

SP1_HUMAN
NC score	0.000093 (rank : 176)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	110	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

SP1_MOUSE
NC score	-0.002118 (rank : 177)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	110	Target Neighborhood Hits	730	Shared Neighborhood Hits	3
SwissProt Accessions	O89090, O89087, Q62251, Q64167	Gene names	Sp1
Domain Architecture
Description	Transcription factor Sp1.