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Network neighborhood for query Sequence : PI4KB_HUMAN

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PI4KB_HUMAN
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PI4KB_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	79	Target Neighborhood Hits	79	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	0 (rank : 2)	NC score	0.996567 (rank : 2)
Query Neighborhood Hits	79	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KA_HUMAN
θ value	3.60269e-49 (rank : 3)	NC score	0.856250 (rank : 3)
Query Neighborhood Hits	79	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PK3CG_HUMAN
θ value	3.50572e-28 (rank : 4)	NC score	0.792846 (rank : 6)
Query Neighborhood Hits	79	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	1.02001e-27 (rank : 5)	NC score	0.791219 (rank : 7)
Query Neighborhood Hits	79	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3C3_MOUSE
θ value	2.96777e-27 (rank : 6)	NC score	0.805089 (rank : 4)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
θ value	1.12775e-26 (rank : 7)	NC score	0.803833 (rank : 5)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CA_HUMAN
θ value	2.77775e-25 (rank : 8)	NC score	0.776610 (rank : 8)
Query Neighborhood Hits	79	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	3.62785e-25 (rank : 9)	NC score	0.776189 (rank : 9)
Query Neighborhood Hits	79	Target Neighborhood Hits	48	Shared Neighborhood Hits	29
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2B_HUMAN
θ value	6.18819e-25 (rank : 10)	NC score	0.666821 (rank : 18)
Query Neighborhood Hits	79	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

P3C2G_MOUSE
θ value	1.37858e-24 (rank : 11)	NC score	0.762576 (rank : 15)
Query Neighborhood Hits	79	Target Neighborhood Hits	113	Shared Neighborhood Hits	30
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_HUMAN
θ value	1.5242e-23 (rank : 12)	NC score	0.762984 (rank : 14)
Query Neighborhood Hits	79	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_HUMAN
θ value	1.99067e-23 (rank : 13)	NC score	0.682624 (rank : 17)
Query Neighborhood Hits	79	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	4.43474e-23 (rank : 14)	NC score	0.685129 (rank : 16)
Query Neighborhood Hits	79	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

PK3CB_HUMAN
θ value	2.87452e-22 (rank : 15)	NC score	0.765674 (rank : 11)
Query Neighborhood Hits	79	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	2.87452e-22 (rank : 16)	NC score	0.765917 (rank : 10)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_MOUSE
θ value	4.15078e-21 (rank : 17)	NC score	0.765129 (rank : 13)
Query Neighborhood Hits	79	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
θ value	5.42112e-21 (rank : 18)	NC score	0.765207 (rank : 12)
Query Neighborhood Hits	79	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

FRAP_HUMAN
θ value	5.81887e-07 (rank : 19)	NC score	0.428972 (rank : 19)
Query Neighborhood Hits	79	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	9.92553e-07 (rank : 20)	NC score	0.428603 (rank : 20)
Query Neighborhood Hits	79	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

PRKDC_MOUSE
θ value	1.43324e-05 (rank : 21)	NC score	0.394248 (rank : 21)
Query Neighborhood Hits	79	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ATM_MOUSE
θ value	1.87187e-05 (rank : 22)	NC score	0.367484 (rank : 26)
Query Neighborhood Hits	79	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATM_HUMAN
θ value	2.44474e-05 (rank : 23)	NC score	0.372818 (rank : 25)
Query Neighborhood Hits	79	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATR_HUMAN
θ value	2.44474e-05 (rank : 24)	NC score	0.376881 (rank : 23)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

PRKDC_HUMAN
θ value	2.44474e-05 (rank : 25)	NC score	0.384119 (rank : 22)
Query Neighborhood Hits	79	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATR_MOUSE
θ value	3.19293e-05 (rank : 26)	NC score	0.376479 (rank : 24)
Query Neighborhood Hits	79	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

SRRM2_HUMAN
θ value	0.0431538 (rank : 27)	NC score	0.035509 (rank : 41)
Query Neighborhood Hits	79	Target Neighborhood Hits	1296	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SMG1_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.281844 (rank : 28)
Query Neighborhood Hits	79	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	0.0736092 (rank : 29)	NC score	0.285072 (rank : 27)
Query Neighborhood Hits	79	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SRRM2_MOUSE
θ value	0.163984 (rank : 30)	NC score	0.031046 (rank : 42)
Query Neighborhood Hits	79	Target Neighborhood Hits	1470	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MYH8_HUMAN
θ value	0.21417 (rank : 31)	NC score	0.016617 (rank : 50)
Query Neighborhood Hits	79	Target Neighborhood Hits	1610	Shared Neighborhood Hits	17
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RPP25_MOUSE
θ value	0.47712 (rank : 32)	NC score	0.069486 (rank : 31)
Query Neighborhood Hits	79	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WE3	Gene names	Rpp25
Domain Architecture	No domain graphic available
Description	Ribonuclease P protein subunit p25 (EC 3.1.26.5) (RNase P protein subunit p25).

MYH4_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.018057 (rank : 47)
Query Neighborhood Hits	79	Target Neighborhood Hits	1377	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH4_MOUSE
θ value	0.813845 (rank : 34)	NC score	0.016357 (rank : 51)
Query Neighborhood Hits	79	Target Neighborhood Hits	1476	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

RBP1_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.020537 (rank : 46)
Query Neighborhood Hits	79	Target Neighborhood Hits	493	Shared Neighborhood Hits	10
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

NUAK2_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.006974 (rank : 71)
Query Neighborhood Hits	79	Target Neighborhood Hits	874	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

AF9_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.021960 (rank : 44)
Query Neighborhood Hits	79	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

G3BP_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.014272 (rank : 56)
Query Neighborhood Hits	79	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

MYH1_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.015544 (rank : 53)
Query Neighborhood Hits	79	Target Neighborhood Hits	1478	Shared Neighborhood Hits	16
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

NUMB_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.021271 (rank : 45)
Query Neighborhood Hits	79	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

SOS1_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.017490 (rank : 48)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

CD2L7_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.006139 (rank : 77)
Query Neighborhood Hits	79	Target Neighborhood Hits	1275	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MYH8_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.013896 (rank : 57)
Query Neighborhood Hits	79	Target Neighborhood Hits	1600	Shared Neighborhood Hits	15
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SGK1_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.006752 (rank : 72)
Query Neighborhood Hits	79	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

MARK2_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.005901 (rank : 78)
Query Neighborhood Hits	79	Target Neighborhood Hits	1056	Shared Neighborhood Hits	20
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MCM3_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.015203 (rank : 54)
Query Neighborhood Hits	79	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

NUAK2_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.006298 (rank : 76)
Query Neighborhood Hits	79	Target Neighborhood Hits	878	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PRKY_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.006355 (rank : 75)
Query Neighborhood Hits	79	Target Neighborhood Hits	844	Shared Neighborhood Hits	16
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

SGK1_MOUSE
θ value	3.0926 (rank : 49)	NC score	0.006461 (rank : 73)
Query Neighborhood Hits	79	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

ATS9_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.005178 (rank : 83)
Query Neighborhood Hits	79	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CHD2_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.005086 (rank : 84)
Query Neighborhood Hits	79	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

LAP2_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.003449 (rank : 87)
Query Neighborhood Hits	79	Target Neighborhood Hits	482	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

SIRT5_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.025563 (rank : 43)
Query Neighborhood Hits	79	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

SYTL2_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.052355 (rank : 38)
Query Neighborhood Hits	79	Target Neighborhood Hits	248	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

KGP2_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.006365 (rank : 74)
Query Neighborhood Hits	79	Target Neighborhood Hits	1023	Shared Neighborhood Hits	22
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PRKX_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.005791 (rank : 79)
Query Neighborhood Hits	79	Target Neighborhood Hits	846	Shared Neighborhood Hits	16
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

RSNL2_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.008840 (rank : 66)
Query Neighborhood Hits	79	Target Neighborhood Hits	129	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

ZBTB6_HUMAN
θ value	5.27518 (rank : 58)	NC score	-0.001994 (rank : 89)
Query Neighborhood Hits	79	Target Neighborhood Hits	805	Shared Neighborhood Hits	7
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).

IF16_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.010485 (rank : 63)
Query Neighborhood Hits	79	Target Neighborhood Hits	182	Shared Neighborhood Hits	6
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

KCNT1_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.009709 (rank : 64)
Query Neighborhood Hits	79	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JUK3, Q9P2C5	Gene names	KCNT1, KIAA1422
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily T member 1 (KCa4.1).

KS6A4_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.005378 (rank : 81)
Query Neighborhood Hits	79	Target Neighborhood Hits	868	Shared Neighborhood Hits	17
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.005302 (rank : 82)
Query Neighborhood Hits	79	Target Neighborhood Hits	866	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MYH1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.014960 (rank : 55)
Query Neighborhood Hits	79	Target Neighborhood Hits	1461	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

NUMB_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.017307 (rank : 49)
Query Neighborhood Hits	79	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

P3H3_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.011668 (rank : 61)
Query Neighborhood Hits	79	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVL6, Q13512, Q15740, Q66K32, Q6NX61, Q7L2T1	Gene names	LEPREL2, P3H3
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 3 precursor (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B).

PGFRB_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.002617 (rank : 88)
Query Neighborhood Hits	79	Target Neighborhood Hits	960	Shared Neighborhood Hits	17
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PRG4_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.007275 (rank : 70)
Query Neighborhood Hits	79	Target Neighborhood Hits	624	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ZCH10_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.016317 (rank : 52)
Query Neighborhood Hits	79	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

CP11A_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.004606 (rank : 86)
Query Neighborhood Hits	79	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

GP143_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.010707 (rank : 62)
Query Neighborhood Hits	79	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P51810	Gene names	GPR143, OA1
Domain Architecture
Description	G-protein coupled receptor 143 (Ocular albinism type 1 protein).

HSF2_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.012825 (rank : 59)
Query Neighborhood Hits	79	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q03933, Q9H445	Gene names	HSF2, HSTF2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

HSF2_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.012851 (rank : 58)
Query Neighborhood Hits	79	Target Neighborhood Hits	153	Shared Neighborhood Hits	9
SwissProt Accessions	P38533, Q64157, Q8VEJ0, Q9Z2L8	Gene names	Hsf2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

KGP2_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.005591 (rank : 80)
Query Neighborhood Hits	79	Target Neighborhood Hits	1029	Shared Neighborhood Hits	21
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

LAD1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.012650 (rank : 60)
Query Neighborhood Hits	79	Target Neighborhood Hits	441	Shared Neighborhood Hits	9
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

NOL8_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.007667 (rank : 69)
Query Neighborhood Hits	79	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.

NOLC1_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.008208 (rank : 67)
Query Neighborhood Hits	79	Target Neighborhood Hits	452	Shared Neighborhood Hits	7
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PHF20_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.007951 (rank : 68)
Query Neighborhood Hits	79	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

PRKX_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.005019 (rank : 85)
Query Neighborhood Hits	79	Target Neighborhood Hits	847	Shared Neighborhood Hits	16
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRP40_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.009000 (rank : 65)
Query Neighborhood Hits	79	Target Neighborhood Hits	447	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

FA62A_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.058193 (rank : 37)
Query Neighborhood Hits	79	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.065060 (rank : 34)
Query Neighborhood Hits	79	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RIMS1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.058423 (rank : 36)
Query Neighborhood Hits	79	Target Neighborhood Hits	437	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS4_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.066807 (rank : 33)
Query Neighborhood Hits	79	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.066816 (rank : 32)
Query Neighborhood Hits	79	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

SYTL1_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.050795 (rank : 40)
Query Neighborhood Hits	79	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SYTL3_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.059359 (rank : 35)
Query Neighborhood Hits	79	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

SYTL5_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.051180 (rank : 39)
Query Neighborhood Hits	79	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TRRAP_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.071677 (rank : 29)
Query Neighborhood Hits	79	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.070747 (rank : 30)
Query Neighborhood Hits	79	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

Hits sorted by NC score

PI4KB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	79	Target Neighborhood Hits	79	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.996567 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	79	Target Neighborhood Hits	67	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PI4KA_HUMAN
NC score	0.856250 (rank : 3)	θ value	3.60269e-49 (rank : 3)
Query Neighborhood Hits	79	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PK3C3_MOUSE
NC score	0.805089 (rank : 4)	θ value	2.96777e-27 (rank : 6)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.803833 (rank : 5)	θ value	1.12775e-26 (rank : 7)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CG_HUMAN
NC score	0.792846 (rank : 6)	θ value	3.50572e-28 (rank : 4)
Query Neighborhood Hits	79	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.791219 (rank : 7)	θ value	1.02001e-27 (rank : 5)
Query Neighborhood Hits	79	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_HUMAN
NC score	0.776610 (rank : 8)	θ value	2.77775e-25 (rank : 8)
Query Neighborhood Hits	79	Target Neighborhood Hits	45	Shared Neighborhood Hits	29
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.776189 (rank : 9)	θ value	3.62785e-25 (rank : 9)
Query Neighborhood Hits	79	Target Neighborhood Hits	48	Shared Neighborhood Hits	29
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CB_MOUSE
NC score	0.765917 (rank : 10)	θ value	2.87452e-22 (rank : 16)
Query Neighborhood Hits	79	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.765674 (rank : 11)	θ value	2.87452e-22 (rank : 15)
Query Neighborhood Hits	79	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
NC score	0.765207 (rank : 12)	θ value	5.42112e-21 (rank : 18)
Query Neighborhood Hits	79	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
NC score	0.765129 (rank : 13)	θ value	4.15078e-21 (rank : 17)
Query Neighborhood Hits	79	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

P3C2G_HUMAN
NC score	0.762984 (rank : 14)	θ value	1.5242e-23 (rank : 12)
Query Neighborhood Hits	79	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
NC score	0.762576 (rank : 15)	θ value	1.37858e-24 (rank : 11)
Query Neighborhood Hits	79	Target Neighborhood Hits	113	Shared Neighborhood Hits	30
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
NC score	0.685129 (rank : 16)	θ value	4.43474e-23 (rank : 14)
Query Neighborhood Hits	79	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.682624 (rank : 17)	θ value	1.99067e-23 (rank : 13)
Query Neighborhood Hits	79	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.666821 (rank : 18)	θ value	6.18819e-25 (rank : 10)
Query Neighborhood Hits	79	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

FRAP_HUMAN
NC score	0.428972 (rank : 19)	θ value	5.81887e-07 (rank : 19)
Query Neighborhood Hits	79	Target Neighborhood Hits	83	Shared Neighborhood Hits	28
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
NC score	0.428603 (rank : 20)	θ value	9.92553e-07 (rank : 20)
Query Neighborhood Hits	79	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

PRKDC_MOUSE
NC score	0.394248 (rank : 21)	θ value	1.43324e-05 (rank : 21)
Query Neighborhood Hits	79	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.384119 (rank : 22)	θ value	2.44474e-05 (rank : 25)
Query Neighborhood Hits	79	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

ATR_HUMAN
NC score	0.376881 (rank : 23)	θ value	2.44474e-05 (rank : 24)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.376479 (rank : 24)	θ value	3.19293e-05 (rank : 26)
Query Neighborhood Hits	79	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
NC score	0.372818 (rank : 25)	θ value	2.44474e-05 (rank : 23)
Query Neighborhood Hits	79	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.367484 (rank : 26)	θ value	1.87187e-05 (rank : 22)
Query Neighborhood Hits	79	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

SMG1_MOUSE
NC score	0.285072 (rank : 27)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	79	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.281844 (rank : 28)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	79	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

TRRAP_HUMAN
NC score	0.071677 (rank : 29)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	79	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
NC score	0.070747 (rank : 30)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	79	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

RPP25_MOUSE
NC score	0.069486 (rank : 31)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	79	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WE3	Gene names	Rpp25
Domain Architecture	No domain graphic available
Description	Ribonuclease P protein subunit p25 (EC 3.1.26.5) (RNase P protein subunit p25).

RIMS4_MOUSE
NC score	0.066816 (rank : 32)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	79	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	P60191	Gene names	Rims4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

RIMS4_HUMAN
NC score	0.066807 (rank : 33)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	79	Target Neighborhood Hits	76	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H426, Q5JWT7	Gene names	RIMS4
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 4 (Rab3-interacting molecule 4) (RIM 4) (RIM4 gamma).

FA62A_MOUSE
NC score	0.065060 (rank : 34)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	79	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL3_MOUSE
NC score	0.059359 (rank : 35)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	79	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q99N48, Q8C506, Q99N47, Q99N49, Q99N54, Q99N79	Gene names	Sytl3, Slp3
Domain Architecture
Description	Synaptotagmin-like protein 3 (Exophilin-6).

RIMS1_HUMAN
NC score	0.058423 (rank : 36)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	79	Target Neighborhood Hits	437	Shared Neighborhood Hits	11
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

FA62A_HUMAN
NC score	0.058193 (rank : 37)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	79	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYTL2_HUMAN
NC score	0.052355 (rank : 38)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	79	Target Neighborhood Hits	248	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCH5, Q2YDA7, Q8ND34, Q96BJ2, Q9H768, Q9NXM1	Gene names	SYTL2, KIAA1597, SLP2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

SYTL5_HUMAN
NC score	0.051180 (rank : 39)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	79	Target Neighborhood Hits	237	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

SYTL1_HUMAN
NC score	0.050795 (rank : 40)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	79	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

SRRM2_HUMAN
NC score	0.035509 (rank : 41)	θ value	0.0431538 (rank : 27)
Query Neighborhood Hits	79	Target Neighborhood Hits	1296	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
NC score	0.031046 (rank : 42)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	79	Target Neighborhood Hits	1470	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SIRT5_MOUSE
NC score	0.025563 (rank : 43)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	79	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K2C6	Gene names	Sirt5, Sir2l5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

AF9_HUMAN
NC score	0.021960 (rank : 44)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	79	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

NUMB_HUMAN
NC score	0.021271 (rank : 45)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	79	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

RBP1_MOUSE
NC score	0.020537 (rank : 46)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	79	Target Neighborhood Hits	493	Shared Neighborhood Hits	10
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

MYH4_HUMAN
NC score	0.018057 (rank : 47)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	79	Target Neighborhood Hits	1377	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

SOS1_HUMAN
NC score	0.017490 (rank : 48)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

NUMB_MOUSE
NC score	0.017307 (rank : 49)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	79	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

MYH8_HUMAN
NC score	0.016617 (rank : 50)	θ value	0.21417 (rank : 31)
Query Neighborhood Hits	79	Target Neighborhood Hits	1610	Shared Neighborhood Hits	17
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_MOUSE
NC score	0.016357 (rank : 51)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	79	Target Neighborhood Hits	1476	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

ZCH10_MOUSE
NC score	0.016317 (rank : 52)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	79	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX48	Gene names	Zcchc10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

MYH1_HUMAN
NC score	0.015544 (rank : 53)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	79	Target Neighborhood Hits	1478	Shared Neighborhood Hits	16
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MCM3_MOUSE
NC score	0.015203 (rank : 54)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	79	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MYH1_MOUSE
NC score	0.014960 (rank : 55)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	79	Target Neighborhood Hits	1461	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

G3BP_HUMAN
NC score	0.014272 (rank : 56)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	79	Target Neighborhood Hits	219	Shared Neighborhood Hits	2
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

MYH8_MOUSE
NC score	0.013896 (rank : 57)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	79	Target Neighborhood Hits	1600	Shared Neighborhood Hits	15
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

HSF2_MOUSE
NC score	0.012851 (rank : 58)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	79	Target Neighborhood Hits	153	Shared Neighborhood Hits	9
SwissProt Accessions	P38533, Q64157, Q8VEJ0, Q9Z2L8	Gene names	Hsf2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

HSF2_HUMAN
NC score	0.012825 (rank : 59)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	79	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q03933, Q9H445	Gene names	HSF2, HSTF2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

LAD1_HUMAN
NC score	0.012650 (rank : 60)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	79	Target Neighborhood Hits	441	Shared Neighborhood Hits	9
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

P3H3_HUMAN
NC score	0.011668 (rank : 61)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	79	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVL6, Q13512, Q15740, Q66K32, Q6NX61, Q7L2T1	Gene names	LEPREL2, P3H3
Domain Architecture	No domain graphic available
Description	Prolyl 3-hydroxylase 3 precursor (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B).

GP143_HUMAN
NC score	0.010707 (rank : 62)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	79	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P51810	Gene names	GPR143, OA1
Domain Architecture
Description	G-protein coupled receptor 143 (Ocular albinism type 1 protein).

IF16_HUMAN
NC score	0.010485 (rank : 63)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	79	Target Neighborhood Hits	182	Shared Neighborhood Hits	6
SwissProt Accessions	Q16666, Q9UH78	Gene names	IFI16, IFNGIP1
Domain Architecture
Description	Gamma-interferon-inducible protein Ifi-16 (Interferon-inducible myeloid differentiation transcriptional activator) (IFI 16).

KCNT1_HUMAN
NC score	0.009709 (rank : 64)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	79	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JUK3, Q9P2C5	Gene names	KCNT1, KIAA1422
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily T member 1 (KCa4.1).

PRP40_MOUSE
NC score	0.009000 (rank : 65)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	79	Target Neighborhood Hits	447	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RSNL2_MOUSE
NC score	0.008840 (rank : 66)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	79	Target Neighborhood Hits	129	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

NOLC1_HUMAN
NC score	0.008208 (rank : 67)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	79	Target Neighborhood Hits	452	Shared Neighborhood Hits	7
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PHF20_HUMAN
NC score	0.007951 (rank : 68)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	79	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

NOL8_MOUSE
NC score	0.007667 (rank : 69)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	79	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHX0, Q504M4, Q8CDJ7, Q9CUR0	Gene names	Nol8
Domain Architecture	No domain graphic available
Description	Nucleolar protein 8.

PRG4_MOUSE
NC score	0.007275 (rank : 70)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	79	Target Neighborhood Hits	624	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

NUAK2_HUMAN
NC score	0.006974 (rank : 71)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	79	Target Neighborhood Hits	874	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

SGK1_HUMAN
NC score	0.006752 (rank : 72)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	79	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
NC score	0.006461 (rank : 73)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	79	Target Neighborhood Hits	848	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KGP2_HUMAN
NC score	0.006365 (rank : 74)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	79	Target Neighborhood Hits	1023	Shared Neighborhood Hits	22
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PRKY_HUMAN
NC score	0.006355 (rank : 75)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	79	Target Neighborhood Hits	844	Shared Neighborhood Hits	16
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.006298 (rank : 76)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	79	Target Neighborhood Hits	878	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

CD2L7_HUMAN
NC score	0.006139 (rank : 77)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	79	Target Neighborhood Hits	1275	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MARK2_HUMAN
NC score	0.005901 (rank : 78)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	79	Target Neighborhood Hits	1056	Shared Neighborhood Hits	20
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PRKX_MOUSE
NC score	0.005791 (rank : 79)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	79	Target Neighborhood Hits	846	Shared Neighborhood Hits	16
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KGP2_MOUSE
NC score	0.005591 (rank : 80)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	79	Target Neighborhood Hits	1029	Shared Neighborhood Hits	21
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6A4_HUMAN
NC score	0.005378 (rank : 81)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	79	Target Neighborhood Hits	868	Shared Neighborhood Hits	17
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
NC score	0.005302 (rank : 82)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	79	Target Neighborhood Hits	866	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

ATS9_HUMAN
NC score	0.005178 (rank : 83)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	79	Target Neighborhood Hits	219	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CHD2_HUMAN
NC score	0.005086 (rank : 84)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	79	Target Neighborhood Hits	360	Shared Neighborhood Hits	5
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

PRKX_HUMAN
NC score	0.005019 (rank : 85)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	79	Target Neighborhood Hits	847	Shared Neighborhood Hits	16
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

CP11A_MOUSE
NC score	0.004606 (rank : 86)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	79	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

LAP2_MOUSE
NC score	0.003449 (rank : 87)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	79	Target Neighborhood Hits	482	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PGFRB_MOUSE
NC score	0.002617 (rank : 88)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	79	Target Neighborhood Hits	960	Shared Neighborhood Hits	17
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

ZBTB6_HUMAN
NC score	-0.001994 (rank : 89)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	79	Target Neighborhood Hits	805	Shared Neighborhood Hits	7
SwissProt Accessions	Q15916	Gene names	ZBTB6, ZID, ZNF482
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) (Zinc finger protein with interaction domain).