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Network neighborhood for query Sequence : ATM_HUMAN

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ATM_HUMAN
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	78	Target Neighborhood Hits	78	Shared Neighborhood Hits	78
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	0 (rank : 2)	NC score	0.990469 (rank : 2)
Query Neighborhood Hits	78	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_MOUSE
θ value	1.18549e-84 (rank : 3)	NC score	0.806565 (rank : 3)
Query Neighborhood Hits	78	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
θ value	1.7238e-59 (rank : 4)	NC score	0.794003 (rank : 4)
Query Neighborhood Hits	78	Target Neighborhood Hits	71	Shared Neighborhood Hits	32
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

FRAP_HUMAN
θ value	1.32601e-43 (rank : 5)	NC score	0.732260 (rank : 6)
Query Neighborhood Hits	78	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	1.32601e-43 (rank : 6)	NC score	0.732867 (rank : 5)
Query Neighborhood Hits	78	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_HUMAN
θ value	3.85808e-43 (rank : 7)	NC score	0.689247 (rank : 8)
Query Neighborhood Hits	78	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	3.85808e-43 (rank : 8)	NC score	0.694780 (rank : 7)
Query Neighborhood Hits	78	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

PRKDC_MOUSE
θ value	6.17384e-33 (rank : 9)	NC score	0.666895 (rank : 9)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	4.42448e-31 (rank : 10)	NC score	0.660001 (rank : 10)
Query Neighborhood Hits	78	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PK3C3_MOUSE
θ value	1.2105e-12 (rank : 11)	NC score	0.474439 (rank : 12)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
θ value	2.0648e-12 (rank : 12)	NC score	0.474562 (rank : 11)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CB_HUMAN
θ value	1.80886e-08 (rank : 13)	NC score	0.379977 (rank : 13)
Query Neighborhood Hits	78	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	2.36244e-08 (rank : 14)	NC score	0.379506 (rank : 14)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	9.92553e-07 (rank : 15)	NC score	0.365132 (rank : 18)
Query Neighborhood Hits	78	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	9.92553e-07 (rank : 16)	NC score	0.365909 (rank : 17)
Query Neighborhood Hits	78	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
θ value	2.88788e-06 (rank : 17)	NC score	0.359790 (rank : 19)
Query Neighborhood Hits	78	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	3.77169e-06 (rank : 18)	NC score	0.357971 (rank : 20)
Query Neighborhood Hits	78	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

TRRAP_HUMAN
θ value	3.77169e-06 (rank : 19)	NC score	0.337551 (rank : 22)
Query Neighborhood Hits	78	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

TRRAP_MOUSE
θ value	1.09739e-05 (rank : 20)	NC score	0.341426 (rank : 21)
Query Neighborhood Hits	78	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PI4KB_HUMAN
θ value	2.44474e-05 (rank : 21)	NC score	0.372818 (rank : 15)
Query Neighborhood Hits	78	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

P3C2G_MOUSE
θ value	4.1701e-05 (rank : 22)	NC score	0.317618 (rank : 25)
Query Neighborhood Hits	78	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KB_MOUSE
θ value	4.1701e-05 (rank : 23)	NC score	0.369049 (rank : 16)
Query Neighborhood Hits	78	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CA_HUMAN
θ value	0.000158464 (rank : 24)	NC score	0.325151 (rank : 23)
Query Neighborhood Hits	78	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0.000158464 (rank : 25)	NC score	0.324958 (rank : 24)
Query Neighborhood Hits	78	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_HUMAN
θ value	0.00020696 (rank : 26)	NC score	0.307354 (rank : 27)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
θ value	0.0252991 (rank : 27)	NC score	0.312126 (rank : 26)
Query Neighborhood Hits	78	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

CCD46_MOUSE
θ value	0.0563607 (rank : 28)	NC score	0.023056 (rank : 43)
Query Neighborhood Hits	78	Target Neighborhood Hits	1405	Shared Neighborhood Hits	23
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CJ118_MOUSE
θ value	0.0563607 (rank : 29)	NC score	0.027254 (rank : 35)
Query Neighborhood Hits	78	Target Neighborhood Hits	1132	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

ST17A_HUMAN
θ value	0.125558 (rank : 30)	NC score	0.004471 (rank : 71)
Query Neighborhood Hits	78	Target Neighborhood Hits	843	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

DMD_MOUSE
θ value	0.365318 (rank : 31)	NC score	0.026224 (rank : 39)
Query Neighborhood Hits	78	Target Neighborhood Hits	1111	Shared Neighborhood Hits	26
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

SMC2_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.026391 (rank : 38)
Query Neighborhood Hits	78	Target Neighborhood Hits	1405	Shared Neighborhood Hits	24
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CJ118_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.025008 (rank : 41)
Query Neighborhood Hits	78	Target Neighborhood Hits	937	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

SYMPK_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.039717 (rank : 31)
Query Neighborhood Hits	78	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

WNK4_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.004638 (rank : 70)
Query Neighborhood Hits	78	Target Neighborhood Hits	1043	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

DMD_HUMAN
θ value	0.813845 (rank : 36)	NC score	0.026600 (rank : 37)
Query Neighborhood Hits	78	Target Neighborhood Hits	1135	Shared Neighborhood Hits	24
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

P3C2A_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.248711 (rank : 29)
Query Neighborhood Hits	78	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	1.06291 (rank : 38)	NC score	0.250589 (rank : 28)
Query Neighborhood Hits	78	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2B_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.232768 (rank : 30)
Query Neighborhood Hits	78	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

SYMPK_HUMAN
θ value	1.06291 (rank : 40)	NC score	0.037723 (rank : 33)
Query Neighborhood Hits	78	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

NUF2_MOUSE
θ value	1.38821 (rank : 41)	NC score	0.023062 (rank : 42)
Query Neighborhood Hits	78	Target Neighborhood Hits	585	Shared Neighborhood Hits	19
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

BPAEA_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.015238 (rank : 51)
Query Neighborhood Hits	78	Target Neighborhood Hits	1369	Shared Neighborhood Hits	21
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CENPF_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.013464 (rank : 55)
Query Neighborhood Hits	78	Target Neighborhood Hits	1932	Shared Neighborhood Hits	24
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

LYST_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.012914 (rank : 58)
Query Neighborhood Hits	78	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MYO1A_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.008429 (rank : 65)
Query Neighborhood Hits	78	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

ROCK1_MOUSE
θ value	1.81305 (rank : 46)	NC score	0.005943 (rank : 67)
Query Neighborhood Hits	78	Target Neighborhood Hits	2126	Shared Neighborhood Hits	28
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ITSN1_MOUSE
θ value	2.36792 (rank : 47)	NC score	0.015296 (rank : 50)
Query Neighborhood Hits	78	Target Neighborhood Hits	1669	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ORC4_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.022428 (rank : 45)
Query Neighborhood Hits	78	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	O88708, Q9QYX1	Gene names	Orc4l, Orc4
Domain Architecture
Description	Origin recognition complex subunit 4.

PAG1_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.038428 (rank : 32)
Query Neighborhood Hits	78	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

ACOX1_MOUSE
θ value	3.0926 (rank : 50)	NC score	0.012814 (rank : 59)
Query Neighborhood Hits	78	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0H0, O35616, Q3TDG0	Gene names	Acox1, Acox, Paox
Domain Architecture
Description	Acyl-coenzyme A oxidase 1, peroxisomal (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (AOX).

CE152_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.017035 (rank : 47)
Query Neighborhood Hits	78	Target Neighborhood Hits	976	Shared Neighborhood Hits	21
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

VPS18_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.032501 (rank : 34)
Query Neighborhood Hits	78	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R307, Q8BGV6, Q8BZX6, Q8C126	Gene names	Vps18
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18.

ERR2_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.003503 (rank : 72)
Query Neighborhood Hits	78	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

IPO8_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.011066 (rank : 62)
Query Neighborhood Hits	78	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

NIM1_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.003254 (rank : 73)
Query Neighborhood Hits	78	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SYGP1_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.016294 (rank : 49)
Query Neighborhood Hits	78	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

FACD2_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.013055 (rank : 57)
Query Neighborhood Hits	78	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

ROBO1_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.001259 (rank : 77)
Query Neighborhood Hits	78	Target Neighborhood Hits	559	Shared Neighborhood Hits	2
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

SRP14_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.022864 (rank : 44)
Query Neighborhood Hits	78	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P16254, Q3TIK2	Gene names	Srp14
Domain Architecture
Description	Signal recognition particle 14 kDa protein (SRP14).

ZN517_HUMAN
θ value	5.27518 (rank : 60)	NC score	-0.002571 (rank : 78)
Query Neighborhood Hits	78	Target Neighborhood Hits	732	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZMY9	Gene names	ZNF517
Domain Architecture	No domain graphic available
Description	Zinc finger protein 517.

IF_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.011513 (rank : 60)
Query Neighborhood Hits	78	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P52787	Gene names	Gif
Domain Architecture
Description	Gastric intrinsic factor precursor (Intrinsic factor) (IF) (INF).

ITSN1_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.011115 (rank : 61)
Query Neighborhood Hits	78	Target Neighborhood Hits	1757	Shared Neighborhood Hits	23
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

RBCC1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.013885 (rank : 54)
Query Neighborhood Hits	78	Target Neighborhood Hits	1048	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

ROCK1_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.005077 (rank : 69)
Query Neighborhood Hits	78	Target Neighborhood Hits	2000	Shared Neighborhood Hits	28
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

RT31_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.014438 (rank : 53)
Query Neighborhood Hits	78	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q61733, Q3TSP5, Q8VEH4, Q9D045	Gene names	Mrps31, Imogn38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

VPS18_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.025595 (rank : 40)
Query Neighborhood Hits	78	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P253, Q8TCG0, Q96DI3, Q9H268	Gene names	VPS18, KIAA1475
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18 (hVPS18).

CDKN3_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.016465 (rank : 48)
Query Neighborhood Hits	78	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

DOCK9_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.005612 (rank : 68)
Query Neighborhood Hits	78	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

GOGA4_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.014700 (rank : 52)
Query Neighborhood Hits	78	Target Neighborhood Hits	2034	Shared Neighborhood Hits	24
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

HELC1_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.007852 (rank : 66)
Query Neighborhood Hits	78	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

KLH23_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.001419 (rank : 76)
Query Neighborhood Hits	78	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NBE8, Q8N9B9, Q96FT8	Gene names	KLHL23
Domain Architecture	No domain graphic available
Description	Kelch-like protein 23.

NIM1_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.002407 (rank : 75)
Query Neighborhood Hits	78	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PLXA3_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.003198 (rank : 74)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	P51805	Gene names	PLXNA3, PLXN4, SEX
Domain Architecture
Description	Plexin-A3 precursor (Plexin-4) (Semaphorin receptor SEX).

RPGR1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.013454 (rank : 56)
Query Neighborhood Hits	78	Target Neighborhood Hits	578	Shared Neighborhood Hits	20
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SF3B1_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.009928 (rank : 63)
Query Neighborhood Hits	78	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.009905 (rank : 64)
Query Neighborhood Hits	78	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SMC2_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.026684 (rank : 36)
Query Neighborhood Hits	78	Target Neighborhood Hits	1131	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SYNE2_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.019002 (rank : 46)
Query Neighborhood Hits	78	Target Neighborhood Hits	1323	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

Hits sorted by NC score

ATM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	78	Target Neighborhood Hits	78	Shared Neighborhood Hits	78
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.990469 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	78	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_MOUSE
NC score	0.806565 (rank : 3)	θ value	1.18549e-84 (rank : 3)
Query Neighborhood Hits	78	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
NC score	0.794003 (rank : 4)	θ value	1.7238e-59 (rank : 4)
Query Neighborhood Hits	78	Target Neighborhood Hits	71	Shared Neighborhood Hits	32
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

FRAP_MOUSE
NC score	0.732867 (rank : 5)	θ value	1.32601e-43 (rank : 6)
Query Neighborhood Hits	78	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.732260 (rank : 6)	θ value	1.32601e-43 (rank : 5)
Query Neighborhood Hits	78	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_MOUSE
NC score	0.694780 (rank : 7)	θ value	3.85808e-43 (rank : 8)
Query Neighborhood Hits	78	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.689247 (rank : 8)	θ value	3.85808e-43 (rank : 7)
Query Neighborhood Hits	78	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PRKDC_MOUSE
NC score	0.666895 (rank : 9)	θ value	6.17384e-33 (rank : 9)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.660001 (rank : 10)	θ value	4.42448e-31 (rank : 10)
Query Neighborhood Hits	78	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PK3C3_HUMAN
NC score	0.474562 (rank : 11)	θ value	2.0648e-12 (rank : 12)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.474439 (rank : 12)	θ value	1.2105e-12 (rank : 11)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CB_HUMAN
NC score	0.379977 (rank : 13)	θ value	1.80886e-08 (rank : 13)
Query Neighborhood Hits	78	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
NC score	0.379506 (rank : 14)	θ value	2.36244e-08 (rank : 14)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PI4KB_HUMAN
NC score	0.372818 (rank : 15)	θ value	2.44474e-05 (rank : 21)
Query Neighborhood Hits	78	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.369049 (rank : 16)	θ value	4.1701e-05 (rank : 23)
Query Neighborhood Hits	78	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CD_MOUSE
NC score	0.365909 (rank : 17)	θ value	9.92553e-07 (rank : 16)
Query Neighborhood Hits	78	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
NC score	0.365132 (rank : 18)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	78	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
NC score	0.359790 (rank : 19)	θ value	2.88788e-06 (rank : 17)
Query Neighborhood Hits	78	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.357971 (rank : 20)	θ value	3.77169e-06 (rank : 18)
Query Neighborhood Hits	78	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

TRRAP_MOUSE
NC score	0.341426 (rank : 21)	θ value	1.09739e-05 (rank : 20)
Query Neighborhood Hits	78	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
NC score	0.337551 (rank : 22)	θ value	3.77169e-06 (rank : 19)
Query Neighborhood Hits	78	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3CA_HUMAN
NC score	0.325151 (rank : 23)	θ value	0.000158464 (rank : 24)
Query Neighborhood Hits	78	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.324958 (rank : 24)	θ value	0.000158464 (rank : 25)
Query Neighborhood Hits	78	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
NC score	0.317618 (rank : 25)	θ value	4.1701e-05 (rank : 22)
Query Neighborhood Hits	78	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.312126 (rank : 26)	θ value	0.0252991 (rank : 27)
Query Neighborhood Hits	78	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2G_HUMAN
NC score	0.307354 (rank : 27)	θ value	0.00020696 (rank : 26)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
NC score	0.250589 (rank : 28)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	78	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.248711 (rank : 29)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	78	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.232768 (rank : 30)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	78	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

SYMPK_MOUSE
NC score	0.039717 (rank : 31)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	78	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

PAG1_HUMAN
NC score	0.038428 (rank : 32)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	78	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

SYMPK_HUMAN
NC score	0.037723 (rank : 33)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	78	Target Neighborhood Hits	90	Shared Neighborhood Hits	4
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

VPS18_MOUSE
NC score	0.032501 (rank : 34)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	78	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R307, Q8BGV6, Q8BZX6, Q8C126	Gene names	Vps18
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18.

CJ118_MOUSE
NC score	0.027254 (rank : 35)	θ value	0.0563607 (rank : 29)
Query Neighborhood Hits	78	Target Neighborhood Hits	1132	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

SMC2_MOUSE
NC score	0.026684 (rank : 36)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	78	Target Neighborhood Hits	1131	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

DMD_HUMAN
NC score	0.026600 (rank : 37)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	78	Target Neighborhood Hits	1135	Shared Neighborhood Hits	24
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

SMC2_HUMAN
NC score	0.026391 (rank : 38)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	78	Target Neighborhood Hits	1405	Shared Neighborhood Hits	24
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

DMD_MOUSE
NC score	0.026224 (rank : 39)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	78	Target Neighborhood Hits	1111	Shared Neighborhood Hits	26
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

VPS18_HUMAN
NC score	0.025595 (rank : 40)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	78	Target Neighborhood Hits	32	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P253, Q8TCG0, Q96DI3, Q9H268	Gene names	VPS18, KIAA1475
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18 (hVPS18).

CJ118_HUMAN
NC score	0.025008 (rank : 41)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	78	Target Neighborhood Hits	937	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

NUF2_MOUSE
NC score	0.023062 (rank : 42)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	78	Target Neighborhood Hits	585	Shared Neighborhood Hits	19
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

CCD46_MOUSE
NC score	0.023056 (rank : 43)	θ value	0.0563607 (rank : 28)
Query Neighborhood Hits	78	Target Neighborhood Hits	1405	Shared Neighborhood Hits	23
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

SRP14_MOUSE
NC score	0.022864 (rank : 44)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	78	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	P16254, Q3TIK2	Gene names	Srp14
Domain Architecture
Description	Signal recognition particle 14 kDa protein (SRP14).

ORC4_MOUSE
NC score	0.022428 (rank : 45)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	78	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	O88708, Q9QYX1	Gene names	Orc4l, Orc4
Domain Architecture
Description	Origin recognition complex subunit 4.

SYNE2_HUMAN
NC score	0.019002 (rank : 46)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	78	Target Neighborhood Hits	1323	Shared Neighborhood Hits	26
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

CE152_HUMAN
NC score	0.017035 (rank : 47)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	78	Target Neighborhood Hits	976	Shared Neighborhood Hits	21
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CDKN3_HUMAN
NC score	0.016465 (rank : 48)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	78	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q16667, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C047, Q9C049, Q9C051, Q9C053	Gene names	CDKN3, CDI1, CIP2, KAP
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.48) (EC 3.1.3.16) (CDK2- associated dual-specificity phosphatase) (Kinase-associated phosphatase) (Cyclin-dependent kinase-interacting protein 2) (Cyclin- dependent kinase interactor 1).

SYGP1_HUMAN
NC score	0.016294 (rank : 49)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	78	Target Neighborhood Hits	589	Shared Neighborhood Hits	17
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

ITSN1_MOUSE
NC score	0.015296 (rank : 50)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	78	Target Neighborhood Hits	1669	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

BPAEA_HUMAN
NC score	0.015238 (rank : 51)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	78	Target Neighborhood Hits	1369	Shared Neighborhood Hits	21
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GOGA4_HUMAN
NC score	0.014700 (rank : 52)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	78	Target Neighborhood Hits	2034	Shared Neighborhood Hits	24
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

RT31_MOUSE
NC score	0.014438 (rank : 53)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	78	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q61733, Q3TSP5, Q8VEH4, Q9D045	Gene names	Mrps31, Imogn38
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S31, mitochondrial precursor (S31mt) (MRP-S31) (Imogen 38).

RBCC1_MOUSE
NC score	0.013885 (rank : 54)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	78	Target Neighborhood Hits	1048	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

CENPF_HUMAN
NC score	0.013464 (rank : 55)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	78	Target Neighborhood Hits	1932	Shared Neighborhood Hits	24
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

RPGR1_HUMAN
NC score	0.013454 (rank : 56)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	78	Target Neighborhood Hits	578	Shared Neighborhood Hits	20
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

FACD2_HUMAN
NC score	0.013055 (rank : 57)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	78	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

LYST_HUMAN
NC score	0.012914 (rank : 58)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	78	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

ACOX1_MOUSE
NC score	0.012814 (rank : 59)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	78	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0H0, O35616, Q3TDG0	Gene names	Acox1, Acox, Paox
Domain Architecture
Description	Acyl-coenzyme A oxidase 1, peroxisomal (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (AOX).

IF_MOUSE
NC score	0.011513 (rank : 60)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	78	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P52787	Gene names	Gif
Domain Architecture
Description	Gastric intrinsic factor precursor (Intrinsic factor) (IF) (INF).

ITSN1_HUMAN
NC score	0.011115 (rank : 61)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	78	Target Neighborhood Hits	1757	Shared Neighborhood Hits	23
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

IPO8_MOUSE
NC score	0.011066 (rank : 62)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	78	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TMY7, Q811I3, Q8C8A9, Q8R2P6, Q8R3V7	Gene names	Ipo8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

SF3B1_HUMAN
NC score	0.009928 (rank : 63)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	78	Target Neighborhood Hits	341	Shared Neighborhood Hits	3
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
NC score	0.009905 (rank : 64)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	78	Target Neighborhood Hits	352	Shared Neighborhood Hits	3
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

MYO1A_HUMAN
NC score	0.008429 (rank : 65)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	78	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

HELC1_HUMAN
NC score	0.007852 (rank : 66)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	78	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

ROCK1_MOUSE
NC score	0.005943 (rank : 67)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	78	Target Neighborhood Hits	2126	Shared Neighborhood Hits	28
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

DOCK9_MOUSE
NC score	0.005612 (rank : 68)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	78	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

ROCK1_HUMAN
NC score	0.005077 (rank : 69)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	78	Target Neighborhood Hits	2000	Shared Neighborhood Hits	28
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

WNK4_HUMAN
NC score	0.004638 (rank : 70)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	78	Target Neighborhood Hits	1043	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ST17A_HUMAN
NC score	0.004471 (rank : 71)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	78	Target Neighborhood Hits	843	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ERR2_MOUSE
NC score	0.003503 (rank : 72)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	78	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q61539, O09067, O09146	Gene names	Esrrb, Err-2, Err2, Nr3b2
Domain Architecture
Description	Steroid hormone receptor ERR2 (Estrogen-related receptor, beta) (ERR- beta) (Estrogen receptor-like 2).

NIM1_MOUSE
NC score	0.003254 (rank : 73)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	78	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PLXA3_HUMAN
NC score	0.003198 (rank : 74)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	P51805	Gene names	PLXNA3, PLXN4, SEX
Domain Architecture
Description	Plexin-A3 precursor (Plexin-4) (Semaphorin receptor SEX).

NIM1_HUMAN
NC score	0.002407 (rank : 75)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	78	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KLH23_HUMAN
NC score	0.001419 (rank : 76)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	78	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NBE8, Q8N9B9, Q96FT8	Gene names	KLHL23
Domain Architecture	No domain graphic available
Description	Kelch-like protein 23.

ROBO1_MOUSE
NC score	0.001259 (rank : 77)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	78	Target Neighborhood Hits	559	Shared Neighborhood Hits	2
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ZN517_HUMAN
NC score	-0.002571 (rank : 78)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	78	Target Neighborhood Hits	732	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZMY9	Gene names	ZNF517
Domain Architecture	No domain graphic available
Description	Zinc finger protein 517.