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Network neighborhood for query Sequence : ATM_MOUSE

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ATM_MOUSE
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATM_HUMAN
θ value	0 (rank : 1)	NC score	0.990469 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	78	Shared Neighborhood Hits	43
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATR_MOUSE
θ value	2.64101e-84 (rank : 3)	NC score	0.812630 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
θ value	2.23575e-83 (rank : 4)	NC score	0.800833 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

FRAP_MOUSE
θ value	1.73182e-43 (rank : 5)	NC score	0.728834 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
θ value	2.95404e-43 (rank : 6)	NC score	0.728033 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_HUMAN
θ value	4.71619e-41 (rank : 7)	NC score	0.684398 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	4.71619e-41 (rank : 8)	NC score	0.689278 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

PRKDC_MOUSE
θ value	3.06405e-32 (rank : 9)	NC score	0.661853 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	2.59387e-31 (rank : 10)	NC score	0.655754 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PK3C3_HUMAN
θ value	8.38298e-14 (rank : 11)	NC score	0.469612 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	5.43371e-13 (rank : 12)	NC score	0.469515 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CB_HUMAN
θ value	1.80886e-08 (rank : 13)	NC score	0.370256 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	3.08544e-08 (rank : 14)	NC score	0.369746 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_HUMAN
θ value	2.21117e-06 (rank : 15)	NC score	0.355535 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	2.21117e-06 (rank : 16)	NC score	0.356312 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PI4KB_HUMAN
θ value	1.87187e-05 (rank : 17)	NC score	0.367484 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PK3CG_HUMAN
θ value	1.87187e-05 (rank : 18)	NC score	0.349645 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
θ value	1.87187e-05 (rank : 19)	NC score	0.347880 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

P3C2G_MOUSE
θ value	2.44474e-05 (rank : 20)	NC score	0.308731 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KB_MOUSE
θ value	3.19293e-05 (rank : 21)	NC score	0.363740 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

TRRAP_HUMAN
θ value	0.000121331 (rank : 22)	NC score	0.325332 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

P3C2G_HUMAN
θ value	0.000270298 (rank : 23)	NC score	0.298416 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

TRRAP_MOUSE
θ value	0.00035302 (rank : 24)	NC score	0.328758 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PK3CA_HUMAN
θ value	0.000461057 (rank : 25)	NC score	0.314936 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0.000461057 (rank : 26)	NC score	0.314750 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

DAPK1_MOUSE
θ value	0.0113563 (rank : 27)	NC score	0.009216 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	1138	Shared Neighborhood Hits	7
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_HUMAN
θ value	0.0252991 (rank : 28)	NC score	0.008859 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	1130	Shared Neighborhood Hits	7
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KI21B_HUMAN
θ value	0.0431538 (rank : 29)	NC score	0.029128 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	1017	Shared Neighborhood Hits	26
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

KI21B_MOUSE
θ value	0.0431538 (rank : 30)	NC score	0.029126 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	997	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

PI4KA_HUMAN
θ value	0.0431538 (rank : 31)	NC score	0.304689 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

CN145_HUMAN
θ value	0.0961366 (rank : 32)	NC score	0.024509 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	1196	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

SMC2_MOUSE
θ value	0.163984 (rank : 33)	NC score	0.034706 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	1131	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

MYH13_HUMAN
θ value	0.279714 (rank : 34)	NC score	0.018566 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	1504	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYO10_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.017198 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	920	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

KI21A_HUMAN
θ value	0.47712 (rank : 36)	NC score	0.025738 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	1543	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

SMC2_HUMAN
θ value	0.47712 (rank : 37)	NC score	0.034905 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	1405	Shared Neighborhood Hits	34
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

GBP1_MOUSE
θ value	0.813845 (rank : 38)	NC score	0.017940 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

ITSN1_MOUSE
θ value	1.06291 (rank : 39)	NC score	0.023204 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	1669	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	1.06291 (rank : 40)	NC score	0.017628 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	1173	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

KI21A_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.025014 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	1317	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

RADI_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.021965 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	741	Shared Neighborhood Hits	25
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

GIMA7_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.020325 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NHV1	Gene names	GIMAP7, IAN7
Domain Architecture	No domain graphic available
Description	GTPase, IMAP family member 7 (Immunity-associated nucleotide 7 protein).

RADI_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.020867 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	773	Shared Neighborhood Hits	24
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

PAG1_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.039146 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

DMD_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.021688 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	31
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

MOES_MOUSE
θ value	2.36792 (rank : 47)	NC score	0.019533 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	923	Shared Neighborhood Hits	27
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

NIM1_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.004896 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PARVG_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.019674 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

WDR67_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.021168 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	476	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

DDX3Y_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.010282 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

ITSN1_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.017529 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	1757	Shared Neighborhood Hits	30
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MOES_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.019709 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYO1A_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.014242 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

NIM1_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.004053 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

OM34_HUMAN
θ value	3.0926 (rank : 56)	NC score	0.010763 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

P3C2A_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.239667 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.241132 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

REST_MOUSE
θ value	3.0926 (rank : 59)	NC score	0.021971 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	1506	Shared Neighborhood Hits	35
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TESC_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.016622 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BS2	Gene names	TESC
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

VPS18_MOUSE
θ value	3.0926 (rank : 61)	NC score	0.032607 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R307, Q8BGV6, Q8BZX6, Q8C126	Gene names	Vps18
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18.

ABCAD_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.005375 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SSE9, Q80T20, Q8BHZ2, Q8CB91	Gene names	Abca13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

DMD_MOUSE
θ value	4.03905 (rank : 63)	NC score	0.021827 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	1111	Shared Neighborhood Hits	35
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

ICK_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.001647 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

OFD1_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.015451 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	753	Shared Neighborhood Hits	23
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

SYGP1_HUMAN
θ value	4.03905 (rank : 66)	NC score	0.018828 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	589	Shared Neighborhood Hits	24
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

TAOK2_MOUSE
θ value	4.03905 (rank : 67)	NC score	0.004863 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	1373	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TIF1A_HUMAN
θ value	4.03905 (rank : 68)	NC score	0.006608 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	327	Shared Neighborhood Hits	6
SwissProt Accessions	O15164, O95854	Gene names	TRIM24, RNF82, TIF1, TIF1A
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24) (RING finger protein 82).

CE110_MOUSE
θ value	5.27518 (rank : 69)	NC score	0.013346 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CEBPZ_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.013183 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

LRBA_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.007755 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	3
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

MCES_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.015005 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

MORC4_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.011515 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

NICN1_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.017863 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQM0	Gene names	Nicn1
Domain Architecture	No domain graphic available
Description	Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24).

P3C2B_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.223266 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

DDX3X_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.008921 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.008946 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.009047 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

PL10_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.008890 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

VPS18_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.025754 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P253, Q8TCG0, Q96DI3, Q9H268	Gene names	VPS18, KIAA1475
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18 (hVPS18).

AF10_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.004879 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

CENPQ_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.014827 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7L2Z9, Q6IN61, Q9NVS5	Gene names	CENPQ, C6orf139
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

CG030_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.012678 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWV0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C7orf30 homolog.

FSTL4_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.002233 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

ITSN2_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.015009 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	1371	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MY18A_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.012847 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	1929	Shared Neighborhood Hits	31
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PB1_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.006979 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

SSRA_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.016039 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P43307, Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2, Q9UN49	Gene names	SSR1, TRAPA
Domain Architecture
Description	Translocon-associated protein subunit alpha precursor (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha).

SSRA_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.016205 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CY50, Q3TIM3, Q99MP2	Gene names	Ssr1
Domain Architecture	No domain graphic available
Description	Translocon-associated protein subunit alpha precursor (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha).

THSD1_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.006463 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TNIP3_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.015480 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	511	Shared Neighborhood Hits	23
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

UBP46_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.005089 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.005089 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

Hits sorted by NC score

ATM_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATM_HUMAN
NC score	0.990469 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	78	Shared Neighborhood Hits	43
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATR_MOUSE
NC score	0.812630 (rank : 3)	θ value	2.64101e-84 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATR_HUMAN
NC score	0.800833 (rank : 4)	θ value	2.23575e-83 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

FRAP_MOUSE
NC score	0.728834 (rank : 5)	θ value	1.73182e-43 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.728033 (rank : 6)	θ value	2.95404e-43 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_MOUSE
NC score	0.689278 (rank : 7)	θ value	4.71619e-41 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.684398 (rank : 8)	θ value	4.71619e-41 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PRKDC_MOUSE
NC score	0.661853 (rank : 9)	θ value	3.06405e-32 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.655754 (rank : 10)	θ value	2.59387e-31 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PK3C3_HUMAN
NC score	0.469612 (rank : 11)	θ value	8.38298e-14 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.469515 (rank : 12)	θ value	5.43371e-13 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CB_HUMAN
NC score	0.370256 (rank : 13)	θ value	1.80886e-08 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
NC score	0.369746 (rank : 14)	θ value	3.08544e-08 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PI4KB_HUMAN
NC score	0.367484 (rank : 15)	θ value	1.87187e-05 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.363740 (rank : 16)	θ value	3.19293e-05 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CD_MOUSE
NC score	0.356312 (rank : 17)	θ value	2.21117e-06 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
NC score	0.355535 (rank : 18)	θ value	2.21117e-06 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CG_HUMAN
NC score	0.349645 (rank : 19)	θ value	1.87187e-05 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.347880 (rank : 20)	θ value	1.87187e-05 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

TRRAP_MOUSE
NC score	0.328758 (rank : 21)	θ value	0.00035302 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
NC score	0.325332 (rank : 22)	θ value	0.000121331 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3CA_HUMAN
NC score	0.314936 (rank : 23)	θ value	0.000461057 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.314750 (rank : 24)	θ value	0.000461057 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
NC score	0.308731 (rank : 25)	θ value	2.44474e-05 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.304689 (rank : 26)	θ value	0.0431538 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2G_HUMAN
NC score	0.298416 (rank : 27)	θ value	0.000270298 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
NC score	0.241132 (rank : 28)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.239667 (rank : 29)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.223266 (rank : 30)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PAG1_HUMAN
NC score	0.039146 (rank : 31)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

SMC2_HUMAN
NC score	0.034905 (rank : 32)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	1405	Shared Neighborhood Hits	34
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SMC2_MOUSE
NC score	0.034706 (rank : 33)	θ value	0.163984 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	1131	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

VPS18_MOUSE
NC score	0.032607 (rank : 34)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R307, Q8BGV6, Q8BZX6, Q8C126	Gene names	Vps18
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18.

KI21B_HUMAN
NC score	0.029128 (rank : 35)	θ value	0.0431538 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	1017	Shared Neighborhood Hits	26
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

KI21B_MOUSE
NC score	0.029126 (rank : 36)	θ value	0.0431538 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	997	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXL1, P97424	Gene names	Kif21b, Kif6
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B (Kinesin-like protein KIF6).

VPS18_HUMAN
NC score	0.025754 (rank : 37)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P253, Q8TCG0, Q96DI3, Q9H268	Gene names	VPS18, KIAA1475
Domain Architecture
Description	Vacuolar protein sorting-associated protein 18 (hVPS18).

KI21A_HUMAN
NC score	0.025738 (rank : 38)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	1543	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

KI21A_MOUSE
NC score	0.025014 (rank : 39)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	1317	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

CN145_HUMAN
NC score	0.024509 (rank : 40)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	1196	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

ITSN1_MOUSE
NC score	0.023204 (rank : 41)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	1669	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

REST_MOUSE
NC score	0.021971 (rank : 42)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	1506	Shared Neighborhood Hits	35
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RADI_HUMAN
NC score	0.021965 (rank : 43)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	741	Shared Neighborhood Hits	25
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

DMD_MOUSE
NC score	0.021827 (rank : 44)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	1111	Shared Neighborhood Hits	35
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DMD_HUMAN
NC score	0.021688 (rank : 45)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	31
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

WDR67_MOUSE
NC score	0.021168 (rank : 46)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	476	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

RADI_MOUSE
NC score	0.020867 (rank : 47)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	773	Shared Neighborhood Hits	24
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

GIMA7_HUMAN
NC score	0.020325 (rank : 48)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NHV1	Gene names	GIMAP7, IAN7
Domain Architecture	No domain graphic available
Description	GTPase, IMAP family member 7 (Immunity-associated nucleotide 7 protein).

MOES_HUMAN
NC score	0.019709 (rank : 49)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	892	Shared Neighborhood Hits	26
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

PARVG_HUMAN
NC score	0.019674 (rank : 50)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

MOES_MOUSE
NC score	0.019533 (rank : 51)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	923	Shared Neighborhood Hits	27
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

SYGP1_HUMAN
NC score	0.018828 (rank : 52)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	589	Shared Neighborhood Hits	24
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

MYH13_HUMAN
NC score	0.018566 (rank : 53)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	1504	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

GBP1_MOUSE
NC score	0.017940 (rank : 54)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

NICN1_MOUSE
NC score	0.017863 (rank : 55)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQM0	Gene names	Nicn1
Domain Architecture	No domain graphic available
Description	Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24).

ITSN2_HUMAN
NC score	0.017628 (rank : 56)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	1173	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
NC score	0.017529 (rank : 57)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	1757	Shared Neighborhood Hits	30
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MYO10_HUMAN
NC score	0.017198 (rank : 58)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	920	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

TESC_HUMAN
NC score	0.016622 (rank : 59)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BS2	Gene names	TESC
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

SSRA_MOUSE
NC score	0.016205 (rank : 60)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CY50, Q3TIM3, Q99MP2	Gene names	Ssr1
Domain Architecture	No domain graphic available
Description	Translocon-associated protein subunit alpha precursor (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha).

SSRA_HUMAN
NC score	0.016039 (rank : 61)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P43307, Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2, Q9UN49	Gene names	SSR1, TRAPA
Domain Architecture
Description	Translocon-associated protein subunit alpha precursor (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha).

TNIP3_HUMAN
NC score	0.015480 (rank : 62)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	511	Shared Neighborhood Hits	23
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

OFD1_HUMAN
NC score	0.015451 (rank : 63)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	753	Shared Neighborhood Hits	23
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

ITSN2_MOUSE
NC score	0.015009 (rank : 64)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	1371	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MCES_HUMAN
NC score	0.015005 (rank : 65)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

CENPQ_HUMAN
NC score	0.014827 (rank : 66)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7L2Z9, Q6IN61, Q9NVS5	Gene names	CENPQ, C6orf139
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

MYO1A_HUMAN
NC score	0.014242 (rank : 67)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

CE110_MOUSE
NC score	0.013346 (rank : 68)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CEBPZ_MOUSE
NC score	0.013183 (rank : 69)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	P53569, Q3TXW5, Q3TYA8, Q3UWQ7	Gene names	Cebpz, Cbf2, Cebpa-rs1
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

MY18A_HUMAN
NC score	0.012847 (rank : 70)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	1929	Shared Neighborhood Hits	31
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CG030_MOUSE
NC score	0.012678 (rank : 71)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	3	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWV0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C7orf30 homolog.

MORC4_HUMAN
NC score	0.011515 (rank : 72)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TE76, Q5JUK7, Q96MZ2, Q9HAI7	Gene names	MORC4, ZCWCC2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

OM34_HUMAN
NC score	0.010763 (rank : 73)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

DDX3Y_MOUSE
NC score	0.010282 (rank : 74)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DAPK1_MOUSE
NC score	0.009216 (rank : 75)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	1138	Shared Neighborhood Hits	7
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DDX3Y_HUMAN
NC score	0.009047 (rank : 76)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX3X_MOUSE
NC score	0.008946 (rank : 77)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3X_HUMAN
NC score	0.008921 (rank : 78)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

PL10_MOUSE
NC score	0.008890 (rank : 79)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	6
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DAPK1_HUMAN
NC score	0.008859 (rank : 80)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	1130	Shared Neighborhood Hits	7
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

LRBA_HUMAN
NC score	0.007755 (rank : 81)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	196	Shared Neighborhood Hits	3
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

PB1_HUMAN
NC score	0.006979 (rank : 82)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

TIF1A_HUMAN
NC score	0.006608 (rank : 83)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	327	Shared Neighborhood Hits	6
SwissProt Accessions	O15164, O95854	Gene names	TRIM24, RNF82, TIF1, TIF1A
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24) (RING finger protein 82).

THSD1_HUMAN
NC score	0.006463 (rank : 84)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ABCAD_MOUSE
NC score	0.005375 (rank : 85)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SSE9, Q80T20, Q8BHZ2, Q8CB91	Gene names	Abca13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

UBP46_HUMAN
NC score	0.005089 (rank : 86)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P62068, Q80V95, Q9H7U4, Q9H9T8	Gene names	USP46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

UBP46_MOUSE
NC score	0.005089 (rank : 87)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	P62069, Q80V95, Q9H7U4, Q9H9T8	Gene names	Usp46
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.1.2.15) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) (Deubiquitinating enzyme 46).

NIM1_MOUSE
NC score	0.004896 (rank : 88)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

AF10_HUMAN
NC score	0.004879 (rank : 89)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

TAOK2_MOUSE
NC score	0.004863 (rank : 90)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	1373	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

NIM1_HUMAN
NC score	0.004053 (rank : 91)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

FSTL4_HUMAN
NC score	0.002233 (rank : 92)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

ICK_HUMAN
NC score	0.001647 (rank : 93)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	867	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).