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Network neighborhood for query Sequence : PARVG_HUMAN

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PARVG_HUMAN
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PARVG_HUMAN
θ value	6.77497e-173 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

PARVG_MOUSE
θ value	1.68428e-139 (rank : 2)	NC score	0.984222 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERD8, Q91X89	Gene names	Parvg
Domain Architecture
Description	Gamma-parvin.

PARVA_HUMAN
θ value	5.00389e-67 (rank : 3)	NC score	0.935559 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NVD7, Q96C85, Q9HA48	Gene names	PARVA
Domain Architecture
Description	Alpha-parvin (Calponin-like integrin-linked kinase-binding protein) (CH-ILKBP).

PARVA_MOUSE
θ value	5.00389e-67 (rank : 4)	NC score	0.935300 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EPC1, Q9JJ65	Gene names	Parva, Actp
Domain Architecture
Description	Alpha-parvin (Actopaxin).

PARVB_HUMAN
θ value	3.96481e-64 (rank : 5)	NC score	0.941038 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

PARVB_MOUSE
θ value	1.84173e-61 (rank : 6)	NC score	0.935719 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ES46	Gene names	Parvb
Domain Architecture
Description	Beta-parvin.

ACTN4_HUMAN
θ value	4.1701e-05 (rank : 7)	NC score	0.238783 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_MOUSE
θ value	4.1701e-05 (rank : 8)	NC score	0.238641 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	276	Shared Neighborhood Hits	35
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN1_HUMAN
θ value	0.000270298 (rank : 9)	NC score	0.234697 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	221	Shared Neighborhood Hits	33
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_MOUSE
θ value	0.000270298 (rank : 10)	NC score	0.235084 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	216	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ASPM_HUMAN
θ value	0.00102713 (rank : 11)	NC score	0.156623 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

FLNB_MOUSE
θ value	0.0193708 (rank : 12)	NC score	0.224973 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	126	Shared Neighborhood Hits	30
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

FLNC_HUMAN
θ value	0.0252991 (rank : 13)	NC score	0.218346 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	116	Shared Neighborhood Hits	30
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

SPTN4_HUMAN
θ value	0.0330416 (rank : 14)	NC score	0.178453 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	570	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

FLNA_HUMAN
θ value	0.0563607 (rank : 15)	NC score	0.219915 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNA_MOUSE
θ value	0.0563607 (rank : 16)	NC score	0.219305 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

SPTB2_HUMAN
θ value	0.0563607 (rank : 17)	NC score	0.167271 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	748	Shared Neighborhood Hits	35
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	0.0563607 (rank : 18)	NC score	0.166756 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	770	Shared Neighborhood Hits	35
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FLNB_HUMAN
θ value	0.0736092 (rank : 19)	NC score	0.211835 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	111	Shared Neighborhood Hits	30
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

ASPM_MOUSE
θ value	0.125558 (rank : 20)	NC score	0.145617 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	150	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

SPTB1_MOUSE
θ value	0.365318 (rank : 21)	NC score	0.166462 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	543	Shared Neighborhood Hits	36
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

BPA1_MOUSE
θ value	0.47712 (rank : 22)	NC score	0.123075 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	1477	Shared Neighborhood Hits	37
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SPTB1_HUMAN
θ value	0.47712 (rank : 23)	NC score	0.171805 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	541	Shared Neighborhood Hits	36
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

DAAM2_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.017696 (rank : 66)
Query Neighborhood Hits	44	Target Neighborhood Hits	350	Shared Neighborhood Hits	7
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DMD_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.095383 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	1111	Shared Neighborhood Hits	34
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

CUL4B_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.014775 (rank : 70)
Query Neighborhood Hits	44	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

MACF1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.127847 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	1341	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF1_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.131186 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	1313	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

ACTN2_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.219388 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	295	Shared Neighborhood Hits	34
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN2_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.219920 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	287	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ATM_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.019674 (rank : 64)
Query Neighborhood Hits	44	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ACTN3_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.223196 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	272	Shared Neighborhood Hits	33
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
θ value	3.0926 (rank : 33)	NC score	0.222996 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	265	Shared Neighborhood Hits	34
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

EEA1_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.024520 (rank : 63)
Query Neighborhood Hits	44	Target Neighborhood Hits	1796	Shared Neighborhood Hits	26
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TRAP1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.016007 (rank : 68)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

KTN1_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.030135 (rank : 61)
Query Neighborhood Hits	44	Target Neighborhood Hits	1324	Shared Neighborhood Hits	27
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

ATR_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.015465 (rank : 69)
Query Neighborhood Hits	44	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

JAK1_HUMAN
θ value	5.27518 (rank : 38)	NC score	-0.000491 (rank : 73)
Query Neighborhood Hits	44	Target Neighborhood Hits	858	Shared Neighborhood Hits	2
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

NFM_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.006570 (rank : 72)
Query Neighborhood Hits	44	Target Neighborhood Hits	1159	Shared Neighborhood Hits	16
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

PRR8_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.016707 (rank : 67)
Query Neighborhood Hits	44	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

KTN1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.026667 (rank : 62)
Query Neighborhood Hits	44	Target Neighborhood Hits	1197	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MMRN1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.010236 (rank : 71)
Query Neighborhood Hits	44	Target Neighborhood Hits	636	Shared Neighborhood Hits	10
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

RAD50_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.018004 (rank : 65)
Query Neighborhood Hits	44	Target Neighborhood Hits	1317	Shared Neighborhood Hits	21
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SPTN5_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.133325 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

BPAEA_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.050590 (rank : 60)
Query Neighborhood Hits	44	Target Neighborhood Hits	1369	Shared Neighborhood Hits	24
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CLMN_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.170722 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

CLMN_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.178893 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	180	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

CYTSA_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.053481 (rank : 58)
Query Neighborhood Hits	44	Target Neighborhood Hits	1138	Shared Neighborhood Hits	32
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.052125 (rank : 59)
Query Neighborhood Hits	44	Target Neighborhood Hits	1104	Shared Neighborhood Hits	32
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DMD_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.099258 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

MICA1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.064443 (rank : 56)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.067251 (rank : 55)
Query Neighborhood Hits	44	Target Neighborhood Hits	400	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.083345 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

MICA2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.071145 (rank : 50)
Query Neighborhood Hits	44	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

MICA3_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.075781 (rank : 49)
Query Neighborhood Hits	44	Target Neighborhood Hits	160	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

MICA3_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.078239 (rank : 48)
Query Neighborhood Hits	44	Target Neighborhood Hits	104	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

MILK1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.094196 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	427	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.082659 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	788	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK2_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.095076 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	457	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

PLEC1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.110545 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	1326	Shared Neighborhood Hits	37
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PLSI_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.061623 (rank : 57)
Query Neighborhood Hits	44	Target Neighborhood Hits	209	Shared Neighborhood Hits	23
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

PLSL_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.067483 (rank : 54)
Query Neighborhood Hits	44	Target Neighborhood Hits	168	Shared Neighborhood Hits	23
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

PLSL_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.069311 (rank : 52)
Query Neighborhood Hits	44	Target Neighborhood Hits	170	Shared Neighborhood Hits	23
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

PLST_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.069339 (rank : 51)
Query Neighborhood Hits	44	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	P13797, Q86YI6	Gene names	PLS3
Domain Architecture
Description	Plastin-3 (T-plastin).

PLST_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.069228 (rank : 53)
Query Neighborhood Hits	44	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q99K51	Gene names	Pls3
Domain Architecture	No domain graphic available
Description	Plastin-3 (T-plastin).

SMOO_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.102029 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	391	Shared Neighborhood Hits	23
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SPTA1_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.093624 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.097133 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	675	Shared Neighborhood Hits	23
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.097038 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	888	Shared Neighborhood Hits	24
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTN2_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.166105 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	535	Shared Neighborhood Hits	34
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SYNE1_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.088198 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	1484	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYNE2_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.087772 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	1323	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

UTRO_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.102643 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	960	Shared Neighborhood Hits	33
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

Hits sorted by NC score

PARVG_HUMAN
NC score	0.999962 (rank : 1)	θ value	6.77497e-173 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

PARVG_MOUSE
NC score	0.984222 (rank : 2)	θ value	1.68428e-139 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	41	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERD8, Q91X89	Gene names	Parvg
Domain Architecture
Description	Gamma-parvin.

PARVB_HUMAN
NC score	0.941038 (rank : 3)	θ value	3.96481e-64 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

PARVB_MOUSE
NC score	0.935719 (rank : 4)	θ value	1.84173e-61 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ES46	Gene names	Parvb
Domain Architecture
Description	Beta-parvin.

PARVA_HUMAN
NC score	0.935559 (rank : 5)	θ value	5.00389e-67 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NVD7, Q96C85, Q9HA48	Gene names	PARVA
Domain Architecture
Description	Alpha-parvin (Calponin-like integrin-linked kinase-binding protein) (CH-ILKBP).

PARVA_MOUSE
NC score	0.935300 (rank : 6)	θ value	5.00389e-67 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EPC1, Q9JJ65	Gene names	Parva, Actp
Domain Architecture
Description	Alpha-parvin (Actopaxin).

ACTN4_HUMAN
NC score	0.238783 (rank : 7)	θ value	4.1701e-05 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN4_MOUSE
NC score	0.238641 (rank : 8)	θ value	4.1701e-05 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	276	Shared Neighborhood Hits	35
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN1_MOUSE
NC score	0.235084 (rank : 9)	θ value	0.000270298 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	216	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_HUMAN
NC score	0.234697 (rank : 10)	θ value	0.000270298 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	221	Shared Neighborhood Hits	33
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

FLNB_MOUSE
NC score	0.224973 (rank : 11)	θ value	0.0193708 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	126	Shared Neighborhood Hits	30
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

ACTN3_HUMAN
NC score	0.223196 (rank : 12)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	272	Shared Neighborhood Hits	33
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
NC score	0.222996 (rank : 13)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	265	Shared Neighborhood Hits	34
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN2_MOUSE
NC score	0.219920 (rank : 14)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	287	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

FLNA_HUMAN
NC score	0.219915 (rank : 15)	θ value	0.0563607 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

ACTN2_HUMAN
NC score	0.219388 (rank : 16)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	295	Shared Neighborhood Hits	34
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

FLNA_MOUSE
NC score	0.219305 (rank : 17)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	142	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNC_HUMAN
NC score	0.218346 (rank : 18)	θ value	0.0252991 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	116	Shared Neighborhood Hits	30
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

FLNB_HUMAN
NC score	0.211835 (rank : 19)	θ value	0.0736092 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	111	Shared Neighborhood Hits	30
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

CLMN_MOUSE
NC score	0.178893 (rank : 20)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	44	Target Neighborhood Hits	180	Shared Neighborhood Hits	30
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

SPTN4_HUMAN
NC score	0.178453 (rank : 21)	θ value	0.0330416 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	570	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTB1_HUMAN
NC score	0.171805 (rank : 22)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	541	Shared Neighborhood Hits	36
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

CLMN_HUMAN
NC score	0.170722 (rank : 23)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	44	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

SPTB2_HUMAN
NC score	0.167271 (rank : 24)	θ value	0.0563607 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	748	Shared Neighborhood Hits	35
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
NC score	0.166756 (rank : 25)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	770	Shared Neighborhood Hits	35
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB1_MOUSE
NC score	0.166462 (rank : 26)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	543	Shared Neighborhood Hits	36
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTN2_HUMAN
NC score	0.166105 (rank : 27)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	44	Target Neighborhood Hits	535	Shared Neighborhood Hits	34
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

ASPM_HUMAN
NC score	0.156623 (rank : 28)	θ value	0.00102713 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

ASPM_MOUSE
NC score	0.145617 (rank : 29)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	150	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

SPTN5_HUMAN
NC score	0.133325 (rank : 30)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

MACF1_MOUSE
NC score	0.131186 (rank : 31)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	1313	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF1_HUMAN
NC score	0.127847 (rank : 32)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	1341	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

BPA1_MOUSE
NC score	0.123075 (rank : 33)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	1477	Shared Neighborhood Hits	37
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PLEC1_HUMAN
NC score	0.110545 (rank : 34)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	44	Target Neighborhood Hits	1326	Shared Neighborhood Hits	37
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

UTRO_HUMAN
NC score	0.102643 (rank : 35)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	44	Target Neighborhood Hits	960	Shared Neighborhood Hits	33
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

SMOO_HUMAN
NC score	0.102029 (rank : 36)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	44	Target Neighborhood Hits	391	Shared Neighborhood Hits	23
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

DMD_HUMAN
NC score	0.099258 (rank : 37)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	44	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

SPTA1_MOUSE
NC score	0.097133 (rank : 38)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	44	Target Neighborhood Hits	675	Shared Neighborhood Hits	23
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
NC score	0.097038 (rank : 39)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	44	Target Neighborhood Hits	888	Shared Neighborhood Hits	24
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DMD_MOUSE
NC score	0.095383 (rank : 40)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	1111	Shared Neighborhood Hits	34
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

MILK2_HUMAN
NC score	0.095076 (rank : 41)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	44	Target Neighborhood Hits	457	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MILK1_HUMAN
NC score	0.094196 (rank : 42)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	44	Target Neighborhood Hits	427	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SPTA1_HUMAN
NC score	0.093624 (rank : 43)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	44	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SYNE1_HUMAN
NC score	0.088198 (rank : 44)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	44	Target Neighborhood Hits	1484	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYNE2_HUMAN
NC score	0.087772 (rank : 45)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	44	Target Neighborhood Hits	1323	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MICA2_HUMAN
NC score	0.083345 (rank : 46)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	44	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

MILK1_MOUSE
NC score	0.082659 (rank : 47)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	44	Target Neighborhood Hits	788	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MICA3_MOUSE
NC score	0.078239 (rank : 48)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	44	Target Neighborhood Hits	104	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

MICA3_HUMAN
NC score	0.075781 (rank : 49)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	44	Target Neighborhood Hits	160	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

MICA2_MOUSE
NC score	0.071145 (rank : 50)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	44	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BML1, Q3UPU6	Gene names	Mical2
Domain Architecture
Description	Protein MICAL-2.

PLST_HUMAN
NC score	0.069339 (rank : 51)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	44	Target Neighborhood Hits	161	Shared Neighborhood Hits	23
SwissProt Accessions	P13797, Q86YI6	Gene names	PLS3
Domain Architecture
Description	Plastin-3 (T-plastin).

PLSL_MOUSE
NC score	0.069311 (rank : 52)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	44	Target Neighborhood Hits	170	Shared Neighborhood Hits	23
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

PLST_MOUSE
NC score	0.069228 (rank : 53)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	44	Target Neighborhood Hits	156	Shared Neighborhood Hits	23
SwissProt Accessions	Q99K51	Gene names	Pls3
Domain Architecture	No domain graphic available
Description	Plastin-3 (T-plastin).

PLSL_HUMAN
NC score	0.067483 (rank : 54)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	44	Target Neighborhood Hits	168	Shared Neighborhood Hits	23
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

MICA1_MOUSE
NC score	0.067251 (rank : 55)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	44	Target Neighborhood Hits	400	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA1_HUMAN
NC score	0.064443 (rank : 56)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

PLSI_HUMAN
NC score	0.061623 (rank : 57)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	44	Target Neighborhood Hits	209	Shared Neighborhood Hits	23
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

CYTSA_HUMAN
NC score	0.053481 (rank : 58)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	44	Target Neighborhood Hits	1138	Shared Neighborhood Hits	32
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
NC score	0.052125 (rank : 59)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	44	Target Neighborhood Hits	1104	Shared Neighborhood Hits	32
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

BPAEA_HUMAN
NC score	0.050590 (rank : 60)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	44	Target Neighborhood Hits	1369	Shared Neighborhood Hits	24
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

KTN1_MOUSE
NC score	0.030135 (rank : 61)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	1324	Shared Neighborhood Hits	27
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

KTN1_HUMAN
NC score	0.026667 (rank : 62)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	1197	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

EEA1_HUMAN
NC score	0.024520 (rank : 63)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	1796	Shared Neighborhood Hits	26
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ATM_MOUSE
NC score	0.019674 (rank : 64)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	93	Shared Neighborhood Hits	4
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

RAD50_HUMAN
NC score	0.018004 (rank : 65)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	1317	Shared Neighborhood Hits	21
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

DAAM2_HUMAN
NC score	0.017696 (rank : 66)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	350	Shared Neighborhood Hits	7
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

PRR8_HUMAN
NC score	0.016707 (rank : 67)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

TRAP1_HUMAN
NC score	0.016007 (rank : 68)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q12931, O43642, O75235, Q9UHL5	Gene names	TRAP1, HSP75
Domain Architecture
Description	Heat shock protein 75 kDa, mitochondrial precursor (HSP 75) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) (TNFR- associated protein 1).

ATR_HUMAN
NC score	0.015465 (rank : 69)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

CUL4B_HUMAN
NC score	0.014775 (rank : 70)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

MMRN1_HUMAN
NC score	0.010236 (rank : 71)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	636	Shared Neighborhood Hits	10
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

NFM_MOUSE
NC score	0.006570 (rank : 72)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1159	Shared Neighborhood Hits	16
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

JAK1_HUMAN
NC score	-0.000491 (rank : 73)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	858	Shared Neighborhood Hits	2
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).