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Network neighborhood for query Sequence : SOCS5_MOUSE

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SOCS5_MOUSE
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SOCS5_HUMAN
θ value	0 (rank : 1)	NC score	0.998968 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS4_HUMAN
θ value	2.2151e-115 (rank : 3)	NC score	0.967102 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	1.48581e-111 (rank : 4)	NC score	0.965996 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	59
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS6_HUMAN
θ value	1.09232e-21 (rank : 5)	NC score	0.707999 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	126	Shared Neighborhood Hits	66
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	1.09232e-21 (rank : 6)	NC score	0.706133 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	146	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS2_HUMAN
θ value	8.38298e-14 (rank : 7)	NC score	0.665908 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	104	Shared Neighborhood Hits	61
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS7_MOUSE
θ value	1.86753e-13 (rank : 8)	NC score	0.678441 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOCS2_MOUSE
θ value	3.18553e-13 (rank : 9)	NC score	0.662627 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	60
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CISH_MOUSE
θ value	1.02475e-11 (rank : 10)	NC score	0.644326 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CISH_HUMAN
θ value	2.28291e-11 (rank : 11)	NC score	0.646597 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SOCS1_MOUSE
θ value	4.45536e-07 (rank : 12)	NC score	0.573108 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS1_HUMAN
θ value	5.81887e-07 (rank : 13)	NC score	0.570419 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	57
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

NCK1_HUMAN
θ value	1.43324e-05 (rank : 14)	NC score	0.221921 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	67
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SOCS3_HUMAN
θ value	9.29e-05 (rank : 15)	NC score	0.519662 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	0.000121331 (rank : 16)	NC score	0.512531 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	72	Shared Neighborhood Hits	46
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

P55G_MOUSE
θ value	0.000270298 (rank : 17)	NC score	0.311040 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	70
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
θ value	0.00035302 (rank : 18)	NC score	0.307549 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CRK_HUMAN
θ value	0.00134147 (rank : 19)	NC score	0.238013 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	308	Shared Neighborhood Hits	72
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.00134147 (rank : 20)	NC score	0.235160 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_MOUSE
θ value	0.00134147 (rank : 21)	NC score	0.280502 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NCK2_HUMAN
θ value	0.00134147 (rank : 22)	NC score	0.214013 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	73
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

P85A_HUMAN
θ value	0.00509761 (rank : 23)	NC score	0.262166 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	479	Shared Neighborhood Hits	71
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	0.00509761 (rank : 24)	NC score	0.264213 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

DAPP1_HUMAN
θ value	0.0113563 (rank : 25)	NC score	0.265015 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P85B_HUMAN
θ value	0.0113563 (rank : 26)	NC score	0.275733 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	543	Shared Neighborhood Hits	74
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0.0148317 (rank : 27)	NC score	0.276034 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	519	Shared Neighborhood Hits	73
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BRWD1_HUMAN
θ value	0.0431538 (rank : 28)	NC score	0.031664 (rank : 108)
Query Neighborhood Hits	93	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

VAV3_HUMAN
θ value	0.0736092 (rank : 29)	NC score	0.154161 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	398	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.153980 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	404	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG2_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.147453 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	280	Shared Neighborhood Hits	64
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

HSH2D_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.186647 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

VAV2_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.132204 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	453	Shared Neighborhood Hits	70
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.21417 (rank : 34)	NC score	0.131228 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CRKL_HUMAN
θ value	0.365318 (rank : 35)	NC score	0.191465 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	313	Shared Neighborhood Hits	70
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

FYV1_HUMAN
θ value	0.365318 (rank : 36)	NC score	0.024436 (rank : 116)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RB40A_HUMAN
θ value	0.365318 (rank : 37)	NC score	0.040878 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXH6, O00407, Q6DK06, Q8TF06	Gene names	RAB40A
Domain Architecture
Description	Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2).

CHIO_HUMAN
θ value	0.47712 (rank : 38)	NC score	0.068229 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	220	Shared Neighborhood Hits	51
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CRKL_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.193419 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FGR_MOUSE
θ value	0.813845 (rank : 40)	NC score	0.051648 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	1069	Shared Neighborhood Hits	74
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

VAV_HUMAN
θ value	0.813845 (rank : 41)	NC score	0.144156 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	452	Shared Neighborhood Hits	66
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ABL1_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.050830 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	1220	Shared Neighborhood Hits	72
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	1.06291 (rank : 43)	NC score	0.050575 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	1178	Shared Neighborhood Hits	71
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	1.06291 (rank : 44)	NC score	0.053501 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	1045	Shared Neighborhood Hits	72
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

RB40C_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.037739 (rank : 104)
Query Neighborhood Hits	93	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S21, O60795, Q4TT41	Gene names	RAB40C, RARL, RASL8C
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3) (Rar- like protein).

RB40C_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.037762 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHQ4	Gene names	Rab40c
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3).

SH22A_HUMAN
θ value	1.38821 (rank : 47)	NC score	0.123449 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SHE_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.176380 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	164	Shared Neighborhood Hits	66
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	1.38821 (rank : 49)	NC score	0.184054 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

HSH2D_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.170010 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	159	Shared Neighborhood Hits	72
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PLCG1_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.149885 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	293	Shared Neighborhood Hits	68
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.148147 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	68
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PTN6_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.067314 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RB40L_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.032841 (rank : 107)
Query Neighborhood Hits	93	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P0C0E4	Gene names	RAB40AL
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-40A-like.

VAV_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.128461 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ZCPW1_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.025854 (rank : 115)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

GRAP2_HUMAN
θ value	2.36792 (rank : 57)	NC score	0.098576 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	304	Shared Neighborhood Hits	60
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NEUL2_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.046392 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BR09, Q3KR34	Gene names	NEURL2, C20orf163
Domain Architecture
Description	Neuralized-like protein 2.

PTN6_MOUSE
θ value	2.36792 (rank : 59)	NC score	0.070509 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SH2D3_HUMAN
θ value	2.36792 (rank : 60)	NC score	0.073517 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SHD_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.161397 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ABLM1_MOUSE
θ value	3.0926 (rank : 62)	NC score	0.009467 (rank : 121)
Query Neighborhood Hits	93	Target Neighborhood Hits	356	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

FGR_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.044337 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	1067	Shared Neighborhood Hits	70
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.040375 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	1078	Shared Neighborhood Hits	69
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	3.0926 (rank : 65)	NC score	0.041231 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	1073	Shared Neighborhood Hits	69
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MATK_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.044217 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	954	Shared Neighborhood Hits	70
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PKCB1_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.014383 (rank : 119)
Query Neighborhood Hits	93	Target Neighborhood Hits	488	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

RB40B_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.027709 (rank : 110)
Query Neighborhood Hits	93	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q12829, Q8WVG3	Gene names	RAB40B, SEC4L
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Rar protein).

SH21B_MOUSE
θ value	3.0926 (rank : 69)	NC score	0.113754 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH23A_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.087224 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SLAP2_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.118888 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	136	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

EVG1_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.021224 (rank : 118)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9S1	Gene names
Domain Architecture
Description	UPF0193 protein EVG1 homolog.

GRAP2_MOUSE
θ value	4.03905 (rank : 73)	NC score	0.096641 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	297	Shared Neighborhood Hits	60
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

RB40B_MOUSE
θ value	4.03905 (rank : 74)	NC score	0.027985 (rank : 109)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHP8	Gene names	Rab40b
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR).

SHC3_MOUSE
θ value	4.03905 (rank : 75)	NC score	0.119262 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	151	Shared Neighborhood Hits	60
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

BLNK_MOUSE
θ value	5.27518 (rank : 76)	NC score	0.060866 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	296	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

GRK5_MOUSE
θ value	5.27518 (rank : 77)	NC score	0.003435 (rank : 123)
Query Neighborhood Hits	93	Target Neighborhood Hits	823	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

SHB_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.169598 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.094752 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.101016 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ATL2_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.007198 (rank : 122)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

RIMB1_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.013415 (rank : 120)
Query Neighborhood Hits	93	Target Neighborhood Hits	1376	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SHD_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.153938 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MATK_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.041750 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	952	Shared Neighborhood Hits	67
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SHB_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.164340 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	66
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SLAP2_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.109424 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

STA5A_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.026569 (rank : 112)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

STA5A_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.026711 (rank : 111)
Query Neighborhood Hits	93	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

STA5B_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.026110 (rank : 113)
Query Neighborhood Hits	93	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STA5B_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.026034 (rank : 114)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	18
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

WSB1_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.021742 (rank : 117)
Query Neighborhood Hits	93	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

YES_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.035562 (rank : 106)
Query Neighborhood Hits	93	Target Neighborhood Hits	1059	Shared Neighborhood Hits	62
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.035671 (rank : 105)
Query Neighborhood Hits	93	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

APS_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.067966 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.052937 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BCAR3_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.073849 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	129	Shared Neighborhood Hits	49
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.068534 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CHIN_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.052123 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.054026 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

GRAP_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.096953 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	56
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.098029 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	309	Shared Neighborhood Hits	57
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB14_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.060554 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	53
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.062097 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.101839 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.103505 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.054285 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LCP2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.068671 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.086023 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.074811 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.080691 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	132	Shared Neighborhood Hits	53
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.061983 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.061991 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RASA1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.083184 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.062736 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.096515 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.056922 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.070578 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	326	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.062604 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHC2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.092517 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.097909 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.115606 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	155	Shared Neighborhood Hits	61
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SLAP1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.077235 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	54
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.080539 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	54
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

Hits sorted by NC score

SOCS5_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS5_HUMAN
NC score	0.998968 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	91	Shared Neighborhood Hits	88
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS4_HUMAN
NC score	0.967102 (rank : 3)	θ value	2.2151e-115 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	59
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
NC score	0.965996 (rank : 4)	θ value	1.48581e-111 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	69	Shared Neighborhood Hits	59
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS6_HUMAN
NC score	0.707999 (rank : 5)	θ value	1.09232e-21 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	126	Shared Neighborhood Hits	66
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.706133 (rank : 6)	θ value	1.09232e-21 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	146	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
NC score	0.678441 (rank : 7)	θ value	1.86753e-13 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	65
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOCS2_HUMAN
NC score	0.665908 (rank : 8)	θ value	8.38298e-14 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	104	Shared Neighborhood Hits	61
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
NC score	0.662627 (rank : 9)	θ value	3.18553e-13 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	60
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CISH_HUMAN
NC score	0.646597 (rank : 10)	θ value	2.28291e-11 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CISH_MOUSE
NC score	0.644326 (rank : 11)	θ value	1.02475e-11 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SOCS1_MOUSE
NC score	0.573108 (rank : 12)	θ value	4.45536e-07 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	82	Shared Neighborhood Hits	57
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS1_HUMAN
NC score	0.570419 (rank : 13)	θ value	5.81887e-07 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	79	Shared Neighborhood Hits	57
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS3_HUMAN
NC score	0.519662 (rank : 14)	θ value	9.29e-05 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
NC score	0.512531 (rank : 15)	θ value	0.000121331 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	72	Shared Neighborhood Hits	46
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

P55G_MOUSE
NC score	0.311040 (rank : 16)	θ value	0.000270298 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	401	Shared Neighborhood Hits	70
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
NC score	0.307549 (rank : 17)	θ value	0.00035302 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	451	Shared Neighborhood Hits	70
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.280502 (rank : 18)	θ value	0.00134147 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P85B_MOUSE
NC score	0.276034 (rank : 19)	θ value	0.0148317 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	519	Shared Neighborhood Hits	73
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_HUMAN
NC score	0.275733 (rank : 20)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	543	Shared Neighborhood Hits	74
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DAPP1_HUMAN
NC score	0.265015 (rank : 21)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P85A_MOUSE
NC score	0.264213 (rank : 22)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
NC score	0.262166 (rank : 23)	θ value	0.00509761 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	479	Shared Neighborhood Hits	71
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CRK_HUMAN
NC score	0.238013 (rank : 24)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	308	Shared Neighborhood Hits	72
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.235160 (rank : 25)	θ value	0.00134147 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCK1_HUMAN
NC score	0.221921 (rank : 26)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	67
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.214013 (rank : 27)	θ value	0.00134147 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	73
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CRKL_MOUSE
NC score	0.193419 (rank : 28)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	71
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.191465 (rank : 29)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	313	Shared Neighborhood Hits	70
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

HSH2D_MOUSE
NC score	0.186647 (rank : 30)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHE_MOUSE
NC score	0.184054 (rank : 31)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	169	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_HUMAN
NC score	0.176380 (rank : 32)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	164	Shared Neighborhood Hits	66
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

HSH2D_HUMAN
NC score	0.170010 (rank : 33)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	159	Shared Neighborhood Hits	72
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHB_HUMAN
NC score	0.169598 (rank : 34)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
NC score	0.164340 (rank : 35)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	66
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_HUMAN
NC score	0.161397 (rank : 36)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	204	Shared Neighborhood Hits	65
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

VAV3_HUMAN
NC score	0.154161 (rank : 37)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	398	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.153980 (rank : 38)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	404	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SHD_MOUSE
NC score	0.153938 (rank : 39)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	63
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

PLCG1_HUMAN
NC score	0.149885 (rank : 40)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	293	Shared Neighborhood Hits	68
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.148147 (rank : 41)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	314	Shared Neighborhood Hits	68
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.147453 (rank : 42)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	280	Shared Neighborhood Hits	64
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV_HUMAN
NC score	0.144156 (rank : 43)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	452	Shared Neighborhood Hits	66
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.132204 (rank : 44)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	453	Shared Neighborhood Hits	70
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.131228 (rank : 45)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	456	Shared Neighborhood Hits	70
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.128461 (rank : 46)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SH22A_HUMAN
NC score	0.123449 (rank : 47)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SHC3_MOUSE
NC score	0.119262 (rank : 48)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	151	Shared Neighborhood Hits	60
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SLAP2_MOUSE
NC score	0.118888 (rank : 49)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	136	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SHC3_HUMAN
NC score	0.115606 (rank : 50)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	93	Target Neighborhood Hits	155	Shared Neighborhood Hits	61
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SH21B_MOUSE
NC score	0.113754 (rank : 51)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SLAP2_HUMAN
NC score	0.109424 (rank : 52)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRB2_MOUSE
NC score	0.103505 (rank : 53)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	93	Target Neighborhood Hits	312	Shared Neighborhood Hits	63
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.101839 (rank : 54)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	93	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SHC1_MOUSE
NC score	0.101016 (rank : 55)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRAP2_HUMAN
NC score	0.098576 (rank : 56)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	304	Shared Neighborhood Hits	60
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_MOUSE
NC score	0.098029 (rank : 57)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	309	Shared Neighborhood Hits	57
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SHC2_MOUSE
NC score	0.097909 (rank : 58)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	93	Target Neighborhood Hits	144	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GRAP_HUMAN
NC score	0.096953 (rank : 59)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	307	Shared Neighborhood Hits	56
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP2_MOUSE
NC score	0.096641 (rank : 60)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	297	Shared Neighborhood Hits	60
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH22A_MOUSE
NC score	0.096515 (rank : 61)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	93	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SHC1_HUMAN
NC score	0.094752 (rank : 62)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
NC score	0.092517 (rank : 63)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SH23A_HUMAN
NC score	0.087224 (rank : 64)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

LCP2_MOUSE
NC score	0.086023 (rank : 65)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	93	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

RASA1_HUMAN
NC score	0.083184 (rank : 66)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	93	Target Neighborhood Hits	258	Shared Neighborhood Hits	57
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LNK_MOUSE
NC score	0.080691 (rank : 67)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	93	Target Neighborhood Hits	132	Shared Neighborhood Hits	53
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SLAP1_MOUSE
NC score	0.080539 (rank : 68)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	54
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP1_HUMAN
NC score	0.077235 (rank : 69)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	93	Target Neighborhood Hits	113	Shared Neighborhood Hits	54
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

LNK_HUMAN
NC score	0.074811 (rank : 70)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	93	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

BCAR3_HUMAN
NC score	0.073849 (rank : 71)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	129	Shared Neighborhood Hits	49
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SH2D3_HUMAN
NC score	0.073517 (rank : 72)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH24A_MOUSE
NC score	0.070578 (rank : 73)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	93	Target Neighborhood Hits	326	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

PTN6_MOUSE
NC score	0.070509 (rank : 74)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	65
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

LCP2_HUMAN
NC score	0.068671 (rank : 75)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	93	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BCAR3_MOUSE
NC score	0.068534 (rank : 76)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CHIO_HUMAN
NC score	0.068229 (rank : 77)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	220	Shared Neighborhood Hits	51
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

APS_HUMAN
NC score	0.067966 (rank : 78)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	162	Shared Neighborhood Hits	50
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

PTN6_HUMAN
NC score	0.067314 (rank : 79)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	234	Shared Neighborhood Hits	64
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SH21B_HUMAN
NC score	0.062736 (rank : 80)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH2D3_MOUSE
NC score	0.062604 (rank : 81)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	93	Target Neighborhood Hits	174	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GRB14_MOUSE
NC score	0.062097 (rank : 82)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	149	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PTN11_MOUSE
NC score	0.061991 (rank : 83)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.061983 (rank : 84)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

BLNK_MOUSE
NC score	0.060866 (rank : 85)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	296	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

GRB14_HUMAN
NC score	0.060554 (rank : 86)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	53
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH24A_HUMAN
NC score	0.056922 (rank : 87)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	93	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

GRB7_MOUSE
NC score	0.054285 (rank : 88)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	93	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CHIN_MOUSE
NC score	0.054026 (rank : 89)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ABL2_HUMAN
NC score	0.053501 (rank : 90)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	1045	Shared Neighborhood Hits	72
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

APS_MOUSE
NC score	0.052937 (rank : 91)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CHIN_HUMAN
NC score	0.052123 (rank : 92)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

FGR_MOUSE
NC score	0.051648 (rank : 93)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	1069	Shared Neighborhood Hits	74
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ABL1_HUMAN
NC score	0.050830 (rank : 94)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	1220	Shared Neighborhood Hits	72
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.050575 (rank : 95)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	1178	Shared Neighborhood Hits	71
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

NEUL2_HUMAN
NC score	0.046392 (rank : 96)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BR09, Q3KR34	Gene names	NEURL2, C20orf163
Domain Architecture
Description	Neuralized-like protein 2.

FGR_HUMAN
NC score	0.044337 (rank : 97)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	1067	Shared Neighborhood Hits	70
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MATK_HUMAN
NC score	0.044217 (rank : 98)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	954	Shared Neighborhood Hits	70
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
NC score	0.041750 (rank : 99)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	952	Shared Neighborhood Hits	67
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FYN_MOUSE
NC score	0.041231 (rank : 100)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	1073	Shared Neighborhood Hits	69
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

RB40A_HUMAN
NC score	0.040878 (rank : 101)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXH6, O00407, Q6DK06, Q8TF06	Gene names	RAB40A
Domain Architecture
Description	Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2).

FYN_HUMAN
NC score	0.040375 (rank : 102)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	1078	Shared Neighborhood Hits	69
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

RB40C_MOUSE
NC score	0.037762 (rank : 103)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHQ4	Gene names	Rab40c
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3).

RB40C_HUMAN
NC score	0.037739 (rank : 104)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S21, O60795, Q4TT41	Gene names	RAB40C, RARL, RASL8C
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3) (Rar- like protein).

YES_MOUSE
NC score	0.035671 (rank : 105)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	1052	Shared Neighborhood Hits	62
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.035562 (rank : 106)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	1059	Shared Neighborhood Hits	62
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

RB40L_HUMAN
NC score	0.032841 (rank : 107)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P0C0E4	Gene names	RAB40AL
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-40A-like.

BRWD1_HUMAN
NC score	0.031664 (rank : 108)	θ value	0.0431538 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

RB40B_MOUSE
NC score	0.027985 (rank : 109)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	265	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHP8	Gene names	Rab40b
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR).

RB40B_HUMAN
NC score	0.027709 (rank : 110)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q12829, Q8WVG3	Gene names	RAB40B, SEC4L
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Rar protein).

STA5A_MOUSE
NC score	0.026711 (rank : 111)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

STA5A_HUMAN
NC score	0.026569 (rank : 112)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

STA5B_HUMAN
NC score	0.026110 (rank : 113)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STA5B_MOUSE
NC score	0.026034 (rank : 114)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	124	Shared Neighborhood Hits	18
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

ZCPW1_HUMAN
NC score	0.025854 (rank : 115)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

FYV1_HUMAN
NC score	0.024436 (rank : 116)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

WSB1_HUMAN
NC score	0.021742 (rank : 117)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6I7, Q9NRB1, Q9UBH9, Q9UNN6	Gene names	WSB1, SWIP1
Domain Architecture
Description	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box- containing WD protein SWiP-1).

EVG1_MOUSE
NC score	0.021224 (rank : 118)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9S1	Gene names
Domain Architecture
Description	UPF0193 protein EVG1 homolog.

PKCB1_HUMAN
NC score	0.014383 (rank : 119)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	488	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

RIMB1_MOUSE
NC score	0.013415 (rank : 120)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	1376	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ABLM1_MOUSE
NC score	0.009467 (rank : 121)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	356	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4G5, Q80U86, Q8BIR9, Q8K4G3, Q8K4G4	Gene names	Ablim1, Ablim, Kiaa0059
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 1 (Actin-binding LIM protein family member 1) (abLIM-1).

ATL2_HUMAN
NC score	0.007198 (rank : 122)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

GRK5_MOUSE
NC score	0.003435 (rank : 123)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	823	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).