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Network neighborhood for query Sequence : S3TC2_HUMAN

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S3TC2_HUMAN
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

S3TC2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC2_MOUSE
θ value	0 (rank : 2)	NC score	0.986787 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC1_HUMAN
θ value	2.17438e-179 (rank : 3)	NC score	0.928880 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

TTC28_HUMAN
θ value	7.59969e-07 (rank : 4)	NC score	0.294556 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
θ value	1.29631e-06 (rank : 5)	NC score	0.304060 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	194	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

GPSM1_MOUSE
θ value	2.21117e-06 (rank : 6)	NC score	0.303943 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q6IR34, Q61366, Q8BUK4, Q8BX78, Q8R0R9	Gene names	Gpsm1, Ags3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM2_MOUSE
θ value	6.43352e-06 (rank : 7)	NC score	0.289466 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDU0, Q8BLX3	Gene names	Gpsm2, Lgn, Pins
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 2 (Pins homolog).

GPSM1_HUMAN
θ value	1.09739e-05 (rank : 8)	NC score	0.296022 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YR5, Q86SR5, Q969T1, Q9UFS8	Gene names	GPSM1, AGS3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM2_HUMAN
θ value	3.19293e-05 (rank : 9)	NC score	0.291787 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P81274, Q8N0Z5	Gene names	GPSM2, LGN
Domain Architecture
Description	G-protein signaling modulator 2 (Mosaic protein LGN).

DNMBP_MOUSE
θ value	0.00175202 (rank : 10)	NC score	0.120208 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
θ value	0.00390308 (rank : 11)	NC score	0.113363 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SPTN2_HUMAN
θ value	0.0330416 (rank : 12)	NC score	0.020094 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	535	Shared Neighborhood Hits	5
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

FYN_HUMAN
θ value	0.0736092 (rank : 13)	NC score	0.043947 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	1078	Shared Neighborhood Hits	39
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0736092 (rank : 14)	NC score	0.044805 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	1073	Shared Neighborhood Hits	39
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
θ value	0.0736092 (rank : 15)	NC score	0.044353 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	1058	Shared Neighborhood Hits	39
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.125558 (rank : 16)	NC score	0.043205 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	1033	Shared Neighborhood Hits	40
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

LCK_HUMAN
θ value	0.163984 (rank : 17)	NC score	0.038207 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	0.163984 (rank : 18)	NC score	0.038021 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	981	Shared Neighborhood Hits	39
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SNAG_HUMAN
θ value	0.163984 (rank : 19)	NC score	0.095147 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SNAG_MOUSE
θ value	0.163984 (rank : 20)	NC score	0.093721 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

FGR_MOUSE
θ value	0.279714 (rank : 21)	NC score	0.044416 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_HUMAN
θ value	0.365318 (rank : 22)	NC score	0.044010 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	1067	Shared Neighborhood Hits	39
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

CF118_HUMAN
θ value	0.47712 (rank : 23)	NC score	0.080513 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T5N4, Q8TC11	Gene names	C6orf118
Domain Architecture	No domain graphic available
Description	Protein C6orf118.

KLC3_MOUSE
θ value	0.62314 (rank : 24)	NC score	0.031537 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	135	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W40, Q3TZ56	Gene names	Klc3
Domain Architecture	No domain graphic available
Description	Kinesin light chain 3.

ANC5_HUMAN
θ value	0.813845 (rank : 25)	NC score	0.051646 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJX4, Q8N4H7, Q9BQD4	Gene names	ANAPC5, APC5
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5).

CDC27_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.068660 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

SH3K1_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.075117 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	1.06291 (rank : 28)	NC score	0.076303 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	332	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STS2_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.043588 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

FYB_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.040108 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	194	Shared Neighborhood Hits	5
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MARK3_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.014536 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	919	Shared Neighborhood Hits	19
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

SRBS1_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.069490 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	409	Shared Neighborhood Hits	34
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

MARK3_HUMAN
θ value	1.81305 (rank : 33)	NC score	0.014841 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	893	Shared Neighborhood Hits	19
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

SH3G1_HUMAN
θ value	1.81305 (rank : 34)	NC score	0.056346 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SRBS1_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.067965 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	396	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

YES_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.041129 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.041423 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	1052	Shared Neighborhood Hits	40
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CD2AP_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.074605 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

EPHA2_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.022874 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	1021	Shared Neighborhood Hits	19
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

FYB_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.034906 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	379	Shared Neighborhood Hits	10
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PACN3_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.051526 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	385	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

VINEX_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.070244 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	270	Shared Neighborhood Hits	35
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.068264 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	286	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRAP2_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.065545 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	304	Shared Neighborhood Hits	34
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.071801 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	297	Shared Neighborhood Hits	35
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

M3K11_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.030387 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	1136	Shared Neighborhood Hits	43
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

OSTF1_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.049010 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	466	Shared Neighborhood Hits	35
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

EPHA2_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.022539 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	1020	Shared Neighborhood Hits	19
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

PACN3_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.048120 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	380	Shared Neighborhood Hits	38
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CD2AP_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.062966 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	315	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

EDAR_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.016701 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

ITSN2_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.033033 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	1371	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LYN_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.035671 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	1023	Shared Neighborhood Hits	37
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3KL4_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.029349 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	1087	Shared Neighborhood Hits	42
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

TTBK1_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.018315 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	1058	Shared Neighborhood Hits	20
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

ZN555_HUMAN
θ value	5.27518 (rank : 56)	NC score	-0.000948 (rank : 85)
Query Neighborhood Hits	70	Target Neighborhood Hits	741	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEP9, Q8NA46, Q96MP1	Gene names	ZNF555
Domain Architecture	No domain graphic available
Description	Zinc finger protein 555.

NCK2_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.059960 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	310	Shared Neighborhood Hits	35
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PK3CD_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.006394 (rank : 81)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

SYIC_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.010953 (rank : 80)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

BBS4_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.026886 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RK4, Q8NHU9, Q96H45	Gene names	BBS4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein.

CE290_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.002612 (rank : 84)
Query Neighborhood Hits	70	Target Neighborhood Hits	1553	Shared Neighborhood Hits	11
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

RB6I2_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.003244 (rank : 83)
Query Neighborhood Hits	70	Target Neighborhood Hits	1584	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.003390 (rank : 82)
Query Neighborhood Hits	70	Target Neighborhood Hits	1433	Shared Neighborhood Hits	11
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

REL1_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.015300 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

SH3G1_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.050467 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	291	Shared Neighborhood Hits	35
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TTC6_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.032493 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TZ1, Q96CE6	Gene names	TTC6
Domain Architecture
Description	Tetratricopeptide repeat protein 6 (TPR repeat protein 6).

TTC8_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.033325 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAM2, Q86SY0, Q86TV9, Q86U26, Q8NDH9, Q96DG8	Gene names	TTC8, BBS8
Domain Architecture
Description	Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet- Biedl syndrome 8 protein).

UBP5_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.012318 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.012319 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

ZFP30_HUMAN
θ value	8.99809 (rank : 70)	NC score	-0.001343 (rank : 86)
Query Neighborhood Hits	70	Target Neighborhood Hits	742	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G7, Q58EY8	Gene names	ZFP30, KIAA0961, ZNF745
Domain Architecture	No domain graphic available
Description	Zinc finger protein 30 homolog (Zfp-30) (Zinc finger protein 745).

GPSM3_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.066546 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4H4	Gene names	GPSM3, AGS4, C6orf9, G18
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3 (Activator of G-protein signaling 4) (Protein G18) (G18.1b).

GPSM3_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.056336 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U1Z5, Q3U1M8, Q3UJZ5, Q8VDF9	Gene names	Gpsm3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3.

GRAP_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.062787 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.060786 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	309	Shared Neighborhood Hits	33
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.054016 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	310	Shared Neighborhood Hits	33
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.053891 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.052210 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCK1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.053353 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PCP2_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.077209 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVA1, Q3KRG7	Gene names	PCP2
Domain Architecture
Description	Purkinje cell protein 2 homolog.

PCP2_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.075178 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

RAPSN_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.067034 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

RAPSN_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.077054 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

SLAP1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.053517 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.053000 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.054581 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.052891 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	136	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

Hits sorted by NC score

S3TC2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC2_MOUSE
NC score	0.986787 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC1_HUMAN
NC score	0.928880 (rank : 3)	θ value	2.17438e-179 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

TTC28_MOUSE
NC score	0.304060 (rank : 4)	θ value	1.29631e-06 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	194	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

GPSM1_MOUSE
NC score	0.303943 (rank : 5)	θ value	2.21117e-06 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q6IR34, Q61366, Q8BUK4, Q8BX78, Q8R0R9	Gene names	Gpsm1, Ags3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM1_HUMAN
NC score	0.296022 (rank : 6)	θ value	1.09739e-05 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YR5, Q86SR5, Q969T1, Q9UFS8	Gene names	GPSM1, AGS3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

TTC28_HUMAN
NC score	0.294556 (rank : 7)	θ value	7.59969e-07 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

GPSM2_HUMAN
NC score	0.291787 (rank : 8)	θ value	3.19293e-05 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P81274, Q8N0Z5	Gene names	GPSM2, LGN
Domain Architecture
Description	G-protein signaling modulator 2 (Mosaic protein LGN).

GPSM2_MOUSE
NC score	0.289466 (rank : 9)	θ value	6.43352e-06 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDU0, Q8BLX3	Gene names	Gpsm2, Lgn, Pins
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 2 (Pins homolog).

DNMBP_MOUSE
NC score	0.120208 (rank : 10)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.113363 (rank : 11)	θ value	0.00390308 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SNAG_HUMAN
NC score	0.095147 (rank : 12)	θ value	0.163984 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q99747, Q9BUV1	Gene names	NAPG, SNAPG
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

SNAG_MOUSE
NC score	0.093721 (rank : 13)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWZ7, Q3TPT4	Gene names	Napg, Snapg
Domain Architecture	No domain graphic available
Description	Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide- sensitive factor attachment protein, gamma).

CF118_HUMAN
NC score	0.080513 (rank : 14)	θ value	0.47712 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T5N4, Q8TC11	Gene names	C6orf118
Domain Architecture	No domain graphic available
Description	Protein C6orf118.

PCP2_HUMAN
NC score	0.077209 (rank : 15)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVA1, Q3KRG7	Gene names	PCP2
Domain Architecture
Description	Purkinje cell protein 2 homolog.

RAPSN_MOUSE
NC score	0.077054 (rank : 16)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

SH3K1_MOUSE
NC score	0.076303 (rank : 17)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	332	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

PCP2_MOUSE
NC score	0.075178 (rank : 18)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	70	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

SH3K1_HUMAN
NC score	0.075117 (rank : 19)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	341	Shared Neighborhood Hits	36
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_MOUSE
NC score	0.074605 (rank : 20)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	336	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GRAP2_MOUSE
NC score	0.071801 (rank : 21)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	297	Shared Neighborhood Hits	35
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

VINEX_HUMAN
NC score	0.070244 (rank : 22)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	270	Shared Neighborhood Hits	35
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SRBS1_MOUSE
NC score	0.069490 (rank : 23)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	409	Shared Neighborhood Hits	34
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CDC27_HUMAN
NC score	0.068660 (rank : 24)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

VINEX_MOUSE
NC score	0.068264 (rank : 25)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	286	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_HUMAN
NC score	0.067965 (rank : 26)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	396	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

RAPSN_HUMAN
NC score	0.067034 (rank : 27)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	70	Target Neighborhood Hits	84	Shared Neighborhood Hits	6
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

GPSM3_HUMAN
NC score	0.066546 (rank : 28)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4H4	Gene names	GPSM3, AGS4, C6orf9, G18
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3 (Activator of G-protein signaling 4) (Protein G18) (G18.1b).

GRAP2_HUMAN
NC score	0.065545 (rank : 29)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	304	Shared Neighborhood Hits	34
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CD2AP_HUMAN
NC score	0.062966 (rank : 30)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	315	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP_HUMAN
NC score	0.062787 (rank : 31)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.060786 (rank : 32)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	309	Shared Neighborhood Hits	33
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.059960 (rank : 33)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	310	Shared Neighborhood Hits	35
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3G1_HUMAN
NC score	0.056346 (rank : 34)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	307	Shared Neighborhood Hits	34
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GPSM3_MOUSE
NC score	0.056336 (rank : 35)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U1Z5, Q3U1M8, Q3UJZ5, Q8VDF9	Gene names	Gpsm3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3.

SLAP2_HUMAN
NC score	0.054581 (rank : 36)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRB2_HUMAN
NC score	0.054016 (rank : 37)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	310	Shared Neighborhood Hits	33
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.053891 (rank : 38)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SLAP1_HUMAN
NC score	0.053517 (rank : 39)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	14
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

NCK1_HUMAN
NC score	0.053353 (rank : 40)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SLAP1_MOUSE
NC score	0.053000 (rank : 41)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	70	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_MOUSE
NC score	0.052891 (rank : 42)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	70	Target Neighborhood Hits	136	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

NCF1_HUMAN
NC score	0.052210 (rank : 43)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ANC5_HUMAN
NC score	0.051646 (rank : 44)	θ value	0.813845 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJX4, Q8N4H7, Q9BQD4	Gene names	ANAPC5, APC5
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5).

PACN3_HUMAN
NC score	0.051526 (rank : 45)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	385	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

SH3G1_MOUSE
NC score	0.050467 (rank : 46)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	291	Shared Neighborhood Hits	35
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

OSTF1_HUMAN
NC score	0.049010 (rank : 47)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	466	Shared Neighborhood Hits	35
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PACN3_MOUSE
NC score	0.048120 (rank : 48)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	380	Shared Neighborhood Hits	38
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

FYN_MOUSE
NC score	0.044805 (rank : 49)	θ value	0.0736092 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	1073	Shared Neighborhood Hits	39
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGR_MOUSE
NC score	0.044416 (rank : 50)	θ value	0.279714 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.044353 (rank : 51)	θ value	0.0736092 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	1058	Shared Neighborhood Hits	39
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_HUMAN
NC score	0.044010 (rank : 52)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	1067	Shared Neighborhood Hits	39
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
NC score	0.043947 (rank : 53)	θ value	0.0736092 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	1078	Shared Neighborhood Hits	39
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

STS2_HUMAN
NC score	0.043588 (rank : 54)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	108	Shared Neighborhood Hits	22
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SRC_MOUSE
NC score	0.043205 (rank : 55)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	1033	Shared Neighborhood Hits	40
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_MOUSE
NC score	0.041423 (rank : 56)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	1052	Shared Neighborhood Hits	40
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.041129 (rank : 57)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	1059	Shared Neighborhood Hits	40
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYB_MOUSE
NC score	0.040108 (rank : 58)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	194	Shared Neighborhood Hits	5
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

LCK_HUMAN
NC score	0.038207 (rank : 59)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
NC score	0.038021 (rank : 60)	θ value	0.163984 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	981	Shared Neighborhood Hits	39
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_MOUSE
NC score	0.035671 (rank : 61)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	1023	Shared Neighborhood Hits	37
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FYB_HUMAN
NC score	0.034906 (rank : 62)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	379	Shared Neighborhood Hits	10
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

TTC8_HUMAN
NC score	0.033325 (rank : 63)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TAM2, Q86SY0, Q86TV9, Q86U26, Q8NDH9, Q96DG8	Gene names	TTC8, BBS8
Domain Architecture
Description	Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet- Biedl syndrome 8 protein).

ITSN2_MOUSE
NC score	0.033033 (rank : 64)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	1371	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

TTC6_HUMAN
NC score	0.032493 (rank : 65)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q86TZ1, Q96CE6	Gene names	TTC6
Domain Architecture
Description	Tetratricopeptide repeat protein 6 (TPR repeat protein 6).

KLC3_MOUSE
NC score	0.031537 (rank : 66)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	135	Shared Neighborhood Hits	7
SwissProt Accessions	Q91W40, Q3TZ56	Gene names	Klc3
Domain Architecture	No domain graphic available
Description	Kinesin light chain 3.

M3K11_HUMAN
NC score	0.030387 (rank : 67)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	1136	Shared Neighborhood Hits	43
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3KL4_HUMAN
NC score	0.029349 (rank : 68)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	1087	Shared Neighborhood Hits	42
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

BBS4_HUMAN
NC score	0.026886 (rank : 69)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q96RK4, Q8NHU9, Q96H45	Gene names	BBS4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein.

EPHA2_HUMAN
NC score	0.022874 (rank : 70)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	1021	Shared Neighborhood Hits	19
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
NC score	0.022539 (rank : 71)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	1020	Shared Neighborhood Hits	19
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

SPTN2_HUMAN
NC score	0.020094 (rank : 72)	θ value	0.0330416 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	535	Shared Neighborhood Hits	5
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

TTBK1_HUMAN
NC score	0.018315 (rank : 73)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	1058	Shared Neighborhood Hits	20
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EDAR_HUMAN
NC score	0.016701 (rank : 74)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNE0, Q9UND9	Gene names	EDAR, DL
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (EDA- A1 receptor) (Ectodermal dysplasia receptor) (Downless homolog).

REL1_MOUSE
NC score	0.015300 (rank : 75)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

MARK3_HUMAN
NC score	0.014841 (rank : 76)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	893	Shared Neighborhood Hits	19
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
NC score	0.014536 (rank : 77)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	919	Shared Neighborhood Hits	19
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

UBP5_MOUSE
NC score	0.012319 (rank : 78)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_HUMAN
NC score	0.012318 (rank : 79)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

SYIC_HUMAN
NC score	0.010953 (rank : 80)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

PK3CD_MOUSE
NC score	0.006394 (rank : 81)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

RB6I2_MOUSE
NC score	0.003390 (rank : 82)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	1433	Shared Neighborhood Hits	11
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RB6I2_HUMAN
NC score	0.003244 (rank : 83)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	1584	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

CE290_HUMAN
NC score	0.002612 (rank : 84)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	1553	Shared Neighborhood Hits	11
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

ZN555_HUMAN
NC score	-0.000948 (rank : 85)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	741	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEP9, Q8NA46, Q96MP1	Gene names	ZNF555
Domain Architecture	No domain graphic available
Description	Zinc finger protein 555.

ZFP30_HUMAN
NC score	-0.001343 (rank : 86)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	742	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G7, Q58EY8	Gene names	ZFP30, KIAA0961, ZNF745
Domain Architecture	No domain graphic available
Description	Zinc finger protein 30 homolog (Zfp-30) (Zinc finger protein 745).