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Network neighborhood for query Sequence : DICER_MOUSE

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DICER_MOUSE
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DICER_HUMAN
θ value	0 (rank : 1)	NC score	0.994583 (rank : 2)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	140	Target Neighborhood Hits	140	Shared Neighborhood Hits	140
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DDX58_HUMAN
θ value	1.37858e-24 (rank : 3)	NC score	0.587644 (rank : 4)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	56
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
θ value	1.38178e-16 (rank : 4)	NC score	0.565354 (rank : 8)
Query Neighborhood Hits	140	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

LGP2_HUMAN
θ value	1.80466e-16 (rank : 5)	NC score	0.588540 (rank : 3)
Query Neighborhood Hits	140	Target Neighborhood Hits	94	Shared Neighborhood Hits	75
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_MOUSE
θ value	1.52774e-15 (rank : 6)	NC score	0.573400 (rank : 7)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

IFIH1_HUMAN
θ value	2.60593e-15 (rank : 7)	NC score	0.580286 (rank : 5)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
θ value	2.0648e-12 (rank : 8)	NC score	0.574109 (rank : 6)
Query Neighborhood Hits	140	Target Neighborhood Hits	86	Shared Neighborhood Hits	72
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

FANCM_HUMAN
θ value	1.9326e-10 (rank : 9)	NC score	0.494386 (rank : 9)
Query Neighborhood Hits	140	Target Neighborhood Hits	210	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

RNC_HUMAN
θ value	1.25267e-09 (rank : 10)	NC score	0.271927 (rank : 80)
Query Neighborhood Hits	140	Target Neighborhood Hits	176	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

FANCM_MOUSE
θ value	6.21693e-09 (rank : 11)	NC score	0.487765 (rank : 10)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

DDX47_HUMAN
θ value	2.21117e-06 (rank : 12)	NC score	0.430701 (rank : 19)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	2.21117e-06 (rank : 13)	NC score	0.430552 (rank : 20)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX3X_HUMAN
θ value	4.92598e-06 (rank : 14)	NC score	0.431607 (rank : 15)
Query Neighborhood Hits	140	Target Neighborhood Hits	122	Shared Neighborhood Hits	82
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	8.40245e-06 (rank : 15)	NC score	0.430860 (rank : 16)
Query Neighborhood Hits	140	Target Neighborhood Hits	117	Shared Neighborhood Hits	82
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

PL10_MOUSE
θ value	8.40245e-06 (rank : 16)	NC score	0.429178 (rank : 21)
Query Neighborhood Hits	140	Target Neighborhood Hits	120	Shared Neighborhood Hits	82
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3Y_HUMAN
θ value	1.87187e-05 (rank : 17)	NC score	0.428984 (rank : 22)
Query Neighborhood Hits	140	Target Neighborhood Hits	121	Shared Neighborhood Hits	82
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

IF4A2_HUMAN
θ value	2.44474e-05 (rank : 18)	NC score	0.432829 (rank : 11)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	2.44474e-05 (rank : 19)	NC score	0.432829 (rank : 12)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A1_HUMAN
θ value	4.1701e-05 (rank : 20)	NC score	0.432620 (rank : 13)
Query Neighborhood Hits	140	Target Neighborhood Hits	106	Shared Neighborhood Hits	82
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	4.1701e-05 (rank : 21)	NC score	0.432620 (rank : 14)
Query Neighborhood Hits	140	Target Neighborhood Hits	106	Shared Neighborhood Hits	82
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX48_HUMAN
θ value	5.44631e-05 (rank : 22)	NC score	0.430795 (rank : 18)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	5.44631e-05 (rank : 23)	NC score	0.430798 (rank : 17)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX27_HUMAN
θ value	7.1131e-05 (rank : 24)	NC score	0.424975 (rank : 26)
Query Neighborhood Hits	140	Target Neighborhood Hits	197	Shared Neighborhood Hits	84
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX3Y_MOUSE
θ value	7.1131e-05 (rank : 25)	NC score	0.427071 (rank : 24)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX4_MOUSE
θ value	0.000158464 (rank : 26)	NC score	0.427412 (rank : 23)
Query Neighborhood Hits	140	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX27_MOUSE
θ value	0.00020696 (rank : 27)	NC score	0.421117 (rank : 27)
Query Neighborhood Hits	140	Target Neighborhood Hits	174	Shared Neighborhood Hits	84
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX4_HUMAN
θ value	0.000270298 (rank : 28)	NC score	0.425101 (rank : 25)
Query Neighborhood Hits	140	Target Neighborhood Hits	123	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX21_HUMAN
θ value	0.000786445 (rank : 29)	NC score	0.415306 (rank : 36)
Query Neighborhood Hits	140	Target Neighborhood Hits	308	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX55_HUMAN
θ value	0.000786445 (rank : 30)	NC score	0.409618 (rank : 41)
Query Neighborhood Hits	140	Target Neighborhood Hits	122	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
θ value	0.000786445 (rank : 31)	NC score	0.409222 (rank : 44)
Query Neighborhood Hits	140	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX24_HUMAN
θ value	0.00102713 (rank : 32)	NC score	0.401518 (rank : 51)
Query Neighborhood Hits	140	Target Neighborhood Hits	190	Shared Neighborhood Hits	81
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX41_HUMAN
θ value	0.00102713 (rank : 33)	NC score	0.416583 (rank : 34)
Query Neighborhood Hits	140	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	0.00102713 (rank : 34)	NC score	0.416609 (rank : 33)
Query Neighborhood Hits	140	Target Neighborhood Hits	115	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

U520_HUMAN
θ value	0.00102713 (rank : 35)	NC score	0.206236 (rank : 83)
Query Neighborhood Hits	140	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

DDX21_MOUSE
θ value	0.00134147 (rank : 36)	NC score	0.409351 (rank : 43)
Query Neighborhood Hits	140	Target Neighborhood Hits	350	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX43_HUMAN
θ value	0.00134147 (rank : 37)	NC score	0.415346 (rank : 35)
Query Neighborhood Hits	140	Target Neighborhood Hits	120	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX50_HUMAN
θ value	0.00134147 (rank : 38)	NC score	0.418611 (rank : 30)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
θ value	0.00134147 (rank : 39)	NC score	0.416874 (rank : 32)
Query Neighborhood Hits	140	Target Neighborhood Hits	137	Shared Neighborhood Hits	82
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX52_MOUSE
θ value	0.00134147 (rank : 40)	NC score	0.420450 (rank : 28)
Query Neighborhood Hits	140	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX46_HUMAN
θ value	0.00175202 (rank : 41)	NC score	0.411599 (rank : 39)
Query Neighborhood Hits	140	Target Neighborhood Hits	357	Shared Neighborhood Hits	85
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	0.00175202 (rank : 42)	NC score	0.410566 (rank : 40)
Query Neighborhood Hits	140	Target Neighborhood Hits	358	Shared Neighborhood Hits	85
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX51_MOUSE
θ value	0.00228821 (rank : 43)	NC score	0.418579 (rank : 31)
Query Neighborhood Hits	140	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX20_MOUSE
θ value	0.00298849 (rank : 44)	NC score	0.395905 (rank : 57)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX20_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.397431 (rank : 56)
Query Neighborhood Hits	140	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX52_HUMAN
θ value	0.00390308 (rank : 46)	NC score	0.419207 (rank : 29)
Query Neighborhood Hits	140	Target Neighborhood Hits	107	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX17_HUMAN
θ value	0.00509761 (rank : 47)	NC score	0.412604 (rank : 38)
Query Neighborhood Hits	140	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	0.00509761 (rank : 48)	NC score	0.412673 (rank : 37)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	82
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX25_HUMAN
θ value	0.00509761 (rank : 49)	NC score	0.402259 (rank : 49)
Query Neighborhood Hits	140	Target Neighborhood Hits	93	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	0.00509761 (rank : 50)	NC score	0.403720 (rank : 48)
Query Neighborhood Hits	140	Target Neighborhood Hits	98	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX51_HUMAN
θ value	0.00509761 (rank : 51)	NC score	0.409479 (rank : 42)
Query Neighborhood Hits	140	Target Neighborhood Hits	332	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX24_MOUSE
θ value	0.00665767 (rank : 52)	NC score	0.397817 (rank : 54)
Query Neighborhood Hits	140	Target Neighborhood Hits	147	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

HELC1_HUMAN
θ value	0.00665767 (rank : 53)	NC score	0.201965 (rank : 84)
Query Neighborhood Hits	140	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

PIWL1_HUMAN
θ value	0.00665767 (rank : 54)	NC score	0.097419 (rank : 91)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J94, O95404, Q8NA60, Q8TBY5, Q96JD5	Gene names	PIWIL1, HIWI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 1.

PIWL1_MOUSE
θ value	0.00869519 (rank : 55)	NC score	0.096706 (rank : 92)
Query Neighborhood Hits	140	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMB7	Gene names	Piwil1, Miwi
Domain Architecture	No domain graphic available
Description	Piwi-like protein 1.

DDX10_HUMAN
θ value	0.0113563 (rank : 56)	NC score	0.388875 (rank : 68)
Query Neighborhood Hits	140	Target Neighborhood Hits	210	Shared Neighborhood Hits	77
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	0.0113563 (rank : 57)	NC score	0.387674 (rank : 69)
Query Neighborhood Hits	140	Target Neighborhood Hits	233	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX23_HUMAN
θ value	0.0148317 (rank : 58)	NC score	0.397450 (rank : 55)
Query Neighborhood Hits	140	Target Neighborhood Hits	486	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX28_HUMAN
θ value	0.0148317 (rank : 59)	NC score	0.384227 (rank : 70)
Query Neighborhood Hits	140	Target Neighborhood Hits	103	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

RECQ4_HUMAN
θ value	0.0193708 (rank : 60)	NC score	0.292864 (rank : 79)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

DDX5_HUMAN
θ value	0.0252991 (rank : 61)	NC score	0.406027 (rank : 46)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	0.0252991 (rank : 62)	NC score	0.406034 (rank : 45)
Query Neighborhood Hits	140	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX49_HUMAN
θ value	0.0330416 (rank : 63)	NC score	0.404950 (rank : 47)
Query Neighborhood Hits	140	Target Neighborhood Hits	223	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX6_HUMAN
θ value	0.0330416 (rank : 64)	NC score	0.400558 (rank : 52)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	0.0330416 (rank : 65)	NC score	0.399124 (rank : 53)
Query Neighborhood Hits	140	Target Neighborhood Hits	98	Shared Neighborhood Hits	82
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DD19A_MOUSE
θ value	0.0431538 (rank : 66)	NC score	0.391180 (rank : 62)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	78
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX39_HUMAN
θ value	0.0431538 (rank : 67)	NC score	0.395611 (rank : 59)
Query Neighborhood Hits	140	Target Neighborhood Hits	94	Shared Neighborhood Hits	81
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
θ value	0.0431538 (rank : 68)	NC score	0.394564 (rank : 60)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DD19A_HUMAN
θ value	0.0563607 (rank : 69)	NC score	0.390612 (rank : 63)
Query Neighborhood Hits	140	Target Neighborhood Hits	107	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
θ value	0.0563607 (rank : 70)	NC score	0.390350 (rank : 65)
Query Neighborhood Hits	140	Target Neighborhood Hits	109	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX49_MOUSE
θ value	0.0736092 (rank : 71)	NC score	0.402038 (rank : 50)
Query Neighborhood Hits	140	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX18_MOUSE
θ value	0.0961366 (rank : 72)	NC score	0.391323 (rank : 61)
Query Neighborhood Hits	140	Target Neighborhood Hits	115	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

TBL2_MOUSE
θ value	0.0961366 (rank : 73)	NC score	0.045026 (rank : 100)
Query Neighborhood Hits	140	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

UAP56_HUMAN
θ value	0.125558 (rank : 74)	NC score	0.389138 (rank : 66)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	0.125558 (rank : 75)	NC score	0.389090 (rank : 67)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX1_HUMAN
θ value	0.163984 (rank : 76)	NC score	0.373464 (rank : 75)
Query Neighborhood Hits	140	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX1_MOUSE
θ value	0.163984 (rank : 77)	NC score	0.374877 (rank : 74)
Query Neighborhood Hits	140	Target Neighborhood Hits	112	Shared Neighborhood Hits	79
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX28_MOUSE
θ value	0.163984 (rank : 78)	NC score	0.395632 (rank : 58)
Query Neighborhood Hits	140	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

PIWL4_MOUSE
θ value	0.163984 (rank : 79)	NC score	0.087156 (rank : 93)
Query Neighborhood Hits	140	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGT6, Q8CC75	Gene names	Piwil4, Miwi2
Domain Architecture	No domain graphic available
Description	Piwi-like protein 4 (mAgo5).

RECQ4_MOUSE
θ value	0.163984 (rank : 80)	NC score	0.269246 (rank : 81)
Query Neighborhood Hits	140	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

DDX18_HUMAN
θ value	0.21417 (rank : 81)	NC score	0.383325 (rank : 71)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

ECM29_MOUSE
θ value	0.21417 (rank : 82)	NC score	0.056071 (rank : 98)
Query Neighborhood Hits	140	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

DDX31_HUMAN
θ value	0.47712 (rank : 83)	NC score	0.378483 (rank : 72)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

PIWL4_HUMAN
θ value	0.47712 (rank : 84)	NC score	0.077912 (rank : 94)
Query Neighborhood Hits	140	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z3Z4, Q68CZ4, Q8N8G9, Q8N9V8, Q8NEH2	Gene names	PIWIL4, HILI2, PIWI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 4.

RECQ1_HUMAN
θ value	0.47712 (rank : 85)	NC score	0.208175 (rank : 82)
Query Neighborhood Hits	140	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DDX53_HUMAN
θ value	0.62314 (rank : 86)	NC score	0.390467 (rank : 64)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX54_MOUSE
θ value	0.62314 (rank : 87)	NC score	0.376487 (rank : 73)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DVL2_HUMAN
θ value	0.62314 (rank : 88)	NC score	0.023961 (rank : 110)
Query Neighborhood Hits	140	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

K1914_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.043860 (rank : 101)
Query Neighborhood Hits	140	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

AN32E_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.028267 (rank : 107)
Query Neighborhood Hits	140	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

AN32A_MOUSE
θ value	1.06291 (rank : 91)	NC score	0.028493 (rank : 105)
Query Neighborhood Hits	140	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	O35381, P97437	Gene names	Anp32a, Anp32, Lanp
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein).

AN32C_MOUSE
θ value	1.06291 (rank : 92)	NC score	0.028493 (rank : 106)
Query Neighborhood Hits	140	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	Q64G17	Gene names	Anp32c
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C.

TICN2_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.018253 (rank : 115)
Query Neighborhood Hits	140	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

ADA19_HUMAN
θ value	1.38821 (rank : 94)	NC score	0.009490 (rank : 129)
Query Neighborhood Hits	140	Target Neighborhood Hits	381	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

CLSPN_HUMAN
θ value	1.38821 (rank : 95)	NC score	0.027236 (rank : 108)
Query Neighborhood Hits	140	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

DVL2_MOUSE
θ value	1.38821 (rank : 96)	NC score	0.021299 (rank : 112)
Query Neighborhood Hits	140	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

GNL1_MOUSE
θ value	1.38821 (rank : 97)	NC score	0.035027 (rank : 103)
Query Neighborhood Hits	140	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P36916	Gene names	Gnl1, Gna-rs1, Mmr1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1).

PIWL2_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.071316 (rank : 95)
Query Neighborhood Hits	140	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDG1, Q3TQE8, Q99MV6, Q9JMB6	Gene names	Piwil2, Mili
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

NKTR_MOUSE
θ value	1.81305 (rank : 99)	NC score	0.012272 (rank : 122)
Query Neighborhood Hits	140	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PIWL2_HUMAN
θ value	1.81305 (rank : 100)	NC score	0.069318 (rank : 96)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TC59, Q96SW6, Q9NW28	Gene names	PIWIL2, HILI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

DDX54_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.372853 (rank : 76)
Query Neighborhood Hits	140	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

NOTC3_MOUSE
θ value	2.36792 (rank : 102)	NC score	0.001363 (rank : 142)
Query Neighborhood Hits	140	Target Neighborhood Hits	975	Shared Neighborhood Hits	6
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PELP1_MOUSE
θ value	2.36792 (rank : 103)	NC score	0.014220 (rank : 120)
Query Neighborhood Hits	140	Target Neighborhood Hits	709	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PPM1F_HUMAN
θ value	2.36792 (rank : 104)	NC score	0.018336 (rank : 114)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

ABTAP_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.016216 (rank : 117)
Query Neighborhood Hits	140	Target Neighborhood Hits	381	Shared Neighborhood Hits	6
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

PTPRD_MOUSE
θ value	3.0926 (rank : 106)	NC score	0.000888 (rank : 143)
Query Neighborhood Hits	140	Target Neighborhood Hits	491	Shared Neighborhood Hits	2
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SUHW3_MOUSE
θ value	3.0926 (rank : 107)	NC score	0.001915 (rank : 141)
Query Neighborhood Hits	140	Target Neighborhood Hits	697	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P3Y5, Q6ZPM2, Q8K145	Gene names	Suhw3, Kiaa1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

TSP4_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.009235 (rank : 131)
Query Neighborhood Hits	140	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_MOUSE
θ value	3.0926 (rank : 109)	NC score	0.009246 (rank : 130)
Query Neighborhood Hits	140	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

GNL1_HUMAN
θ value	4.03905 (rank : 110)	NC score	0.029358 (rank : 104)
Query Neighborhood Hits	140	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P36915	Gene names	GNL1, HSR1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1).

HERC2_MOUSE
θ value	4.03905 (rank : 111)	NC score	0.015132 (rank : 118)
Query Neighborhood Hits	140	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

K1914_MOUSE
θ value	4.03905 (rank : 112)	NC score	0.041902 (rank : 102)
Query Neighborhood Hits	140	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

M3K6_HUMAN
θ value	4.03905 (rank : 113)	NC score	-0.003421 (rank : 147)
Query Neighborhood Hits	140	Target Neighborhood Hits	889	Shared Neighborhood Hits	2
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

MRC2_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.012501 (rank : 121)
Query Neighborhood Hits	140	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBG0, Q7LGE7, Q9Y5P9	Gene names	MRC2, ENDO180, KIAA0709, UPARAP
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Urokinase receptor-associated protein) (Endocytic receptor 180) (CD280 antigen).

RECQ1_MOUSE
θ value	4.03905 (rank : 115)	NC score	0.195917 (rank : 86)
Query Neighborhood Hits	140	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

ZBTB1_MOUSE
θ value	4.03905 (rank : 116)	NC score	-0.000713 (rank : 146)
Query Neighborhood Hits	140	Target Neighborhood Hits	795	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZN687_MOUSE
θ value	4.03905 (rank : 117)	NC score	0.002113 (rank : 140)
Query Neighborhood Hits	140	Target Neighborhood Hits	913	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ENW1_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.025836 (rank : 109)
Query Neighborhood Hits	140	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

HERC2_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.014926 (rank : 119)
Query Neighborhood Hits	140	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

PRELP_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.002554 (rank : 139)
Query Neighborhood Hits	140	Target Neighborhood Hits	295	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JK53	Gene names	Prelp
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

UBE2W_MOUSE
θ value	5.27518 (rank : 121)	NC score	0.011801 (rank : 123)
Query Neighborhood Hits	140	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDW4, Q9D5H3	Gene names	Ube2w
Domain Architecture	No domain graphic available
Description	Probable ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (Ubiquitin- protein ligase W) (Ubiquitin carrier protein W).

ZN687_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.000870 (rank : 144)
Query Neighborhood Hits	140	Target Neighborhood Hits	1244	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

DCBD2_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.004803 (rank : 137)
Query Neighborhood Hits	140	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

KLDC5_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.005307 (rank : 136)
Query Neighborhood Hits	140	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFQ9, Q6ZPT4	Gene names	Klhdc5, Kiaa1340
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 5.

MRC2_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.010305 (rank : 128)
Query Neighborhood Hits	140	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q64449, Q6ZQ64, Q8C6P0	Gene names	Mrc2, Kiaa0709
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Lectin lambda) (CD280 antigen).

PDIA4_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.006464 (rank : 134)
Query Neighborhood Hits	140	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

UBE2W_HUMAN
θ value	6.88961 (rank : 127)	NC score	0.010727 (rank : 127)
Query Neighborhood Hits	140	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q96B02, Q9H823, Q9HAG6, Q9NV07	Gene names	UBE2W
Domain Architecture	No domain graphic available
Description	Probable ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (Ubiquitin- protein ligase W) (Ubiquitin carrier protein W).

WRN_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.190066 (rank : 89)
Query Neighborhood Hits	140	Target Neighborhood Hits	295	Shared Neighborhood Hits	79
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

YTDC1_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.011104 (rank : 126)
Query Neighborhood Hits	140	Target Neighborhood Hits	458	Shared Neighborhood Hits	8
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ANK3_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.000395 (rank : 145)
Query Neighborhood Hits	140	Target Neighborhood Hits	853	Shared Neighborhood Hits	7
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

APBB1_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.006762 (rank : 133)
Query Neighborhood Hits	140	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

CLCN5_MOUSE
θ value	8.99809 (rank : 132)	NC score	0.004428 (rank : 138)
Query Neighborhood Hits	140	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVD4	Gene names	Clcn5, Clc5
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

DUS3_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.005572 (rank : 135)
Query Neighborhood Hits	140	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

ISY1_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.020996 (rank : 113)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

ISY1_MOUSE
θ value	8.99809 (rank : 135)	NC score	0.021316 (rank : 111)
Query Neighborhood Hits	140	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZQ2, Q8VDX4, Q9D3E2	Gene names	Kiaa1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

MRE11_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.011543 (rank : 124)
Query Neighborhood Hits	140	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P49959, O43475	Gene names	MRE11A, HNGS1, MRE11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A).

NU153_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.011537 (rank : 125)
Query Neighborhood Hits	140	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

PARP9_MOUSE
θ value	8.99809 (rank : 138)	NC score	0.008045 (rank : 132)
Query Neighborhood Hits	140	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CAS9, Q99LF9	Gene names	Parp9, Bal
Domain Architecture
Description	Poly [ADP-ribose] polymerase 9 (EC 2.4.2.30) (PARP-9) (B aggressive lymphoma protein homolog).

TBL2_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.017218 (rank : 116)
Query Neighborhood Hits	140	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

WRN_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.201951 (rank : 85)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	79
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

BLM_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.189853 (rank : 90)
Query Neighborhood Hits	140	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.194726 (rank : 87)
Query Neighborhood Hits	140	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

CC026_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.062842 (rank : 97)
Query Neighborhood Hits	140	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

DDX56_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.352376 (rank : 78)
Query Neighborhood Hits	140	Target Neighborhood Hits	77	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.352759 (rank : 77)
Query Neighborhood Hits	140	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

PIWL3_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.053937 (rank : 99)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3Z3	Gene names	PIWIL3
Domain Architecture	No domain graphic available
Description	Piwi-like protein 3.

RECQ5_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.194362 (rank : 88)
Query Neighborhood Hits	140	Target Neighborhood Hits	390	Shared Neighborhood Hits	74
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

Hits sorted by NC score

DICER_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	140	Target Neighborhood Hits	140	Shared Neighborhood Hits	140
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
NC score	0.994583 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

LGP2_HUMAN
NC score	0.588540 (rank : 3)	θ value	1.80466e-16 (rank : 5)
Query Neighborhood Hits	140	Target Neighborhood Hits	94	Shared Neighborhood Hits	75
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DDX58_HUMAN
NC score	0.587644 (rank : 4)	θ value	1.37858e-24 (rank : 3)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	56
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

IFIH1_HUMAN
NC score	0.580286 (rank : 5)	θ value	2.60593e-15 (rank : 7)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
NC score	0.574109 (rank : 6)	θ value	2.0648e-12 (rank : 8)
Query Neighborhood Hits	140	Target Neighborhood Hits	86	Shared Neighborhood Hits	72
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_MOUSE
NC score	0.573400 (rank : 7)	θ value	1.52774e-15 (rank : 6)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DDX58_MOUSE
NC score	0.565354 (rank : 8)	θ value	1.38178e-16 (rank : 4)
Query Neighborhood Hits	140	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

FANCM_HUMAN
NC score	0.494386 (rank : 9)	θ value	1.9326e-10 (rank : 9)
Query Neighborhood Hits	140	Target Neighborhood Hits	210	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.487765 (rank : 10)	θ value	6.21693e-09 (rank : 11)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

IF4A2_HUMAN
NC score	0.432829 (rank : 11)	θ value	2.44474e-05 (rank : 18)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.432829 (rank : 12)	θ value	2.44474e-05 (rank : 19)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A1_HUMAN
NC score	0.432620 (rank : 13)	θ value	4.1701e-05 (rank : 20)
Query Neighborhood Hits	140	Target Neighborhood Hits	106	Shared Neighborhood Hits	82
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.432620 (rank : 14)	θ value	4.1701e-05 (rank : 21)
Query Neighborhood Hits	140	Target Neighborhood Hits	106	Shared Neighborhood Hits	82
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX3X_HUMAN
NC score	0.431607 (rank : 15)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	140	Target Neighborhood Hits	122	Shared Neighborhood Hits	82
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
NC score	0.430860 (rank : 16)	θ value	8.40245e-06 (rank : 15)
Query Neighborhood Hits	140	Target Neighborhood Hits	117	Shared Neighborhood Hits	82
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX48_MOUSE
NC score	0.430798 (rank : 17)	θ value	5.44631e-05 (rank : 23)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX48_HUMAN
NC score	0.430795 (rank : 18)	θ value	5.44631e-05 (rank : 22)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX47_HUMAN
NC score	0.430701 (rank : 19)	θ value	2.21117e-06 (rank : 12)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
NC score	0.430552 (rank : 20)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

PL10_MOUSE
NC score	0.429178 (rank : 21)	θ value	8.40245e-06 (rank : 16)
Query Neighborhood Hits	140	Target Neighborhood Hits	120	Shared Neighborhood Hits	82
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3Y_HUMAN
NC score	0.428984 (rank : 22)	θ value	1.87187e-05 (rank : 17)
Query Neighborhood Hits	140	Target Neighborhood Hits	121	Shared Neighborhood Hits	82
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX4_MOUSE
NC score	0.427412 (rank : 23)	θ value	0.000158464 (rank : 26)
Query Neighborhood Hits	140	Target Neighborhood Hits	100	Shared Neighborhood Hits	84
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX3Y_MOUSE
NC score	0.427071 (rank : 24)	θ value	7.1131e-05 (rank : 25)
Query Neighborhood Hits	140	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX4_HUMAN
NC score	0.425101 (rank : 25)	θ value	0.000270298 (rank : 28)
Query Neighborhood Hits	140	Target Neighborhood Hits	123	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX27_HUMAN
NC score	0.424975 (rank : 26)	θ value	7.1131e-05 (rank : 24)
Query Neighborhood Hits	140	Target Neighborhood Hits	197	Shared Neighborhood Hits	84
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_MOUSE
NC score	0.421117 (rank : 27)	θ value	0.00020696 (rank : 27)
Query Neighborhood Hits	140	Target Neighborhood Hits	174	Shared Neighborhood Hits	84
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX52_MOUSE
NC score	0.420450 (rank : 28)	θ value	0.00134147 (rank : 40)
Query Neighborhood Hits	140	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_HUMAN
NC score	0.419207 (rank : 29)	θ value	0.00390308 (rank : 46)
Query Neighborhood Hits	140	Target Neighborhood Hits	107	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX50_HUMAN
NC score	0.418611 (rank : 30)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX51_MOUSE
NC score	0.418579 (rank : 31)	θ value	0.00228821 (rank : 43)
Query Neighborhood Hits	140	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX50_MOUSE
NC score	0.416874 (rank : 32)	θ value	0.00134147 (rank : 39)
Query Neighborhood Hits	140	Target Neighborhood Hits	137	Shared Neighborhood Hits	82
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX41_MOUSE
NC score	0.416609 (rank : 33)	θ value	0.00102713 (rank : 34)
Query Neighborhood Hits	140	Target Neighborhood Hits	115	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX41_HUMAN
NC score	0.416583 (rank : 34)	θ value	0.00102713 (rank : 33)
Query Neighborhood Hits	140	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX43_HUMAN
NC score	0.415346 (rank : 35)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	140	Target Neighborhood Hits	120	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX21_HUMAN
NC score	0.415306 (rank : 36)	θ value	0.000786445 (rank : 29)
Query Neighborhood Hits	140	Target Neighborhood Hits	308	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX17_MOUSE
NC score	0.412673 (rank : 37)	θ value	0.00509761 (rank : 48)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	82
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.412604 (rank : 38)	θ value	0.00509761 (rank : 47)
Query Neighborhood Hits	140	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX46_HUMAN
NC score	0.411599 (rank : 39)	θ value	0.00175202 (rank : 41)
Query Neighborhood Hits	140	Target Neighborhood Hits	357	Shared Neighborhood Hits	85
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.410566 (rank : 40)	θ value	0.00175202 (rank : 42)
Query Neighborhood Hits	140	Target Neighborhood Hits	358	Shared Neighborhood Hits	85
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX55_HUMAN
NC score	0.409618 (rank : 41)	θ value	0.000786445 (rank : 30)
Query Neighborhood Hits	140	Target Neighborhood Hits	122	Shared Neighborhood Hits	81
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX51_HUMAN
NC score	0.409479 (rank : 42)	θ value	0.00509761 (rank : 51)
Query Neighborhood Hits	140	Target Neighborhood Hits	332	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX21_MOUSE
NC score	0.409351 (rank : 43)	θ value	0.00134147 (rank : 36)
Query Neighborhood Hits	140	Target Neighborhood Hits	350	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX55_MOUSE
NC score	0.409222 (rank : 44)	θ value	0.000786445 (rank : 31)
Query Neighborhood Hits	140	Target Neighborhood Hits	111	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX5_MOUSE
NC score	0.406034 (rank : 45)	θ value	0.0252991 (rank : 62)
Query Neighborhood Hits	140	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX5_HUMAN
NC score	0.406027 (rank : 46)	θ value	0.0252991 (rank : 61)
Query Neighborhood Hits	140	Target Neighborhood Hits	102	Shared Neighborhood Hits	82
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX49_HUMAN
NC score	0.404950 (rank : 47)	θ value	0.0330416 (rank : 63)
Query Neighborhood Hits	140	Target Neighborhood Hits	223	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX25_MOUSE
NC score	0.403720 (rank : 48)	θ value	0.00509761 (rank : 50)
Query Neighborhood Hits	140	Target Neighborhood Hits	98	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
NC score	0.402259 (rank : 49)	θ value	0.00509761 (rank : 49)
Query Neighborhood Hits	140	Target Neighborhood Hits	93	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX49_MOUSE
NC score	0.402038 (rank : 50)	θ value	0.0736092 (rank : 71)
Query Neighborhood Hits	140	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX24_HUMAN
NC score	0.401518 (rank : 51)	θ value	0.00102713 (rank : 32)
Query Neighborhood Hits	140	Target Neighborhood Hits	190	Shared Neighborhood Hits	81
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX6_HUMAN
NC score	0.400558 (rank : 52)	θ value	0.0330416 (rank : 64)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.399124 (rank : 53)	θ value	0.0330416 (rank : 65)
Query Neighborhood Hits	140	Target Neighborhood Hits	98	Shared Neighborhood Hits	82
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX24_MOUSE
NC score	0.397817 (rank : 54)	θ value	0.00665767 (rank : 52)
Query Neighborhood Hits	140	Target Neighborhood Hits	147	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX23_HUMAN
NC score	0.397450 (rank : 55)	θ value	0.0148317 (rank : 58)
Query Neighborhood Hits	140	Target Neighborhood Hits	486	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX20_HUMAN
NC score	0.397431 (rank : 56)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	140	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
NC score	0.395905 (rank : 57)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX28_MOUSE
NC score	0.395632 (rank : 58)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	140	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX39_HUMAN
NC score	0.395611 (rank : 59)	θ value	0.0431538 (rank : 67)
Query Neighborhood Hits	140	Target Neighborhood Hits	94	Shared Neighborhood Hits	81
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
NC score	0.394564 (rank : 60)	θ value	0.0431538 (rank : 68)
Query Neighborhood Hits	140	Target Neighborhood Hits	97	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX18_MOUSE
NC score	0.391323 (rank : 61)	θ value	0.0961366 (rank : 72)
Query Neighborhood Hits	140	Target Neighborhood Hits	115	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DD19A_MOUSE
NC score	0.391180 (rank : 62)	θ value	0.0431538 (rank : 66)
Query Neighborhood Hits	140	Target Neighborhood Hits	105	Shared Neighborhood Hits	78
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19A_HUMAN
NC score	0.390612 (rank : 63)	θ value	0.0563607 (rank : 69)
Query Neighborhood Hits	140	Target Neighborhood Hits	107	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DDX53_HUMAN
NC score	0.390467 (rank : 64)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DD19B_HUMAN
NC score	0.390350 (rank : 65)	θ value	0.0563607 (rank : 70)
Query Neighborhood Hits	140	Target Neighborhood Hits	109	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

UAP56_HUMAN
NC score	0.389138 (rank : 66)	θ value	0.125558 (rank : 74)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.389090 (rank : 67)	θ value	0.125558 (rank : 75)
Query Neighborhood Hits	140	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX10_HUMAN
NC score	0.388875 (rank : 68)	θ value	0.0113563 (rank : 56)
Query Neighborhood Hits	140	Target Neighborhood Hits	210	Shared Neighborhood Hits	77
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
NC score	0.387674 (rank : 69)	θ value	0.0113563 (rank : 57)
Query Neighborhood Hits	140	Target Neighborhood Hits	233	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX28_HUMAN
NC score	0.384227 (rank : 70)	θ value	0.0148317 (rank : 59)
Query Neighborhood Hits	140	Target Neighborhood Hits	103	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX18_HUMAN
NC score	0.383325 (rank : 71)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX31_HUMAN
NC score	0.378483 (rank : 72)	θ value	0.47712 (rank : 83)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX54_MOUSE
NC score	0.376487 (rank : 73)	θ value	0.62314 (rank : 87)
Query Neighborhood Hits	140	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX1_MOUSE
NC score	0.374877 (rank : 74)	θ value	0.163984 (rank : 77)
Query Neighborhood Hits	140	Target Neighborhood Hits	112	Shared Neighborhood Hits	79
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.373464 (rank : 75)	θ value	0.163984 (rank : 76)
Query Neighborhood Hits	140	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX54_HUMAN
NC score	0.372853 (rank : 76)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	140	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX56_MOUSE
NC score	0.352759 (rank : 77)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	140	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX56_HUMAN
NC score	0.352376 (rank : 78)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	140	Target Neighborhood Hits	77	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

RECQ4_HUMAN
NC score	0.292864 (rank : 79)	θ value	0.0193708 (rank : 60)
Query Neighborhood Hits	140	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RNC_HUMAN
NC score	0.271927 (rank : 80)	θ value	1.25267e-09 (rank : 10)
Query Neighborhood Hits	140	Target Neighborhood Hits	176	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

RECQ4_MOUSE
NC score	0.269246 (rank : 81)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	140	Target Neighborhood Hits	206	Shared Neighborhood Hits	80
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ1_HUMAN
NC score	0.208175 (rank : 82)	θ value	0.47712 (rank : 85)
Query Neighborhood Hits	140	Target Neighborhood Hits	100	Shared Neighborhood Hits	72
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

U520_HUMAN
NC score	0.206236 (rank : 83)	θ value	0.00102713 (rank : 35)
Query Neighborhood Hits	140	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

HELC1_HUMAN
NC score	0.201965 (rank : 84)	θ value	0.00665767 (rank : 53)
Query Neighborhood Hits	140	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

WRN_HUMAN
NC score	0.201951 (rank : 85)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	140	Target Neighborhood Hits	132	Shared Neighborhood Hits	79
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ1_MOUSE
NC score	0.195917 (rank : 86)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	140	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

BLM_MOUSE
NC score	0.194726 (rank : 87)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	140	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

RECQ5_HUMAN
NC score	0.194362 (rank : 88)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	140	Target Neighborhood Hits	390	Shared Neighborhood Hits	74
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_MOUSE
NC score	0.190066 (rank : 89)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	140	Target Neighborhood Hits	295	Shared Neighborhood Hits	79
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

BLM_HUMAN
NC score	0.189853 (rank : 90)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	140	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

PIWL1_HUMAN
NC score	0.097419 (rank : 91)	θ value	0.00665767 (rank : 54)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J94, O95404, Q8NA60, Q8TBY5, Q96JD5	Gene names	PIWIL1, HIWI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 1.

PIWL1_MOUSE
NC score	0.096706 (rank : 92)	θ value	0.00869519 (rank : 55)
Query Neighborhood Hits	140	Target Neighborhood Hits	29	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JMB7	Gene names	Piwil1, Miwi
Domain Architecture	No domain graphic available
Description	Piwi-like protein 1.

PIWL4_MOUSE
NC score	0.087156 (rank : 93)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	140	Target Neighborhood Hits	34	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGT6, Q8CC75	Gene names	Piwil4, Miwi2
Domain Architecture	No domain graphic available
Description	Piwi-like protein 4 (mAgo5).

PIWL4_HUMAN
NC score	0.077912 (rank : 94)	θ value	0.47712 (rank : 84)
Query Neighborhood Hits	140	Target Neighborhood Hits	22	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z3Z4, Q68CZ4, Q8N8G9, Q8N9V8, Q8NEH2	Gene names	PIWIL4, HILI2, PIWI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 4.

PIWL2_MOUSE
NC score	0.071316 (rank : 95)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	140	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDG1, Q3TQE8, Q99MV6, Q9JMB6	Gene names	Piwil2, Mili
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

PIWL2_HUMAN
NC score	0.069318 (rank : 96)	θ value	1.81305 (rank : 100)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TC59, Q96SW6, Q9NW28	Gene names	PIWIL2, HILI
Domain Architecture	No domain graphic available
Description	Piwi-like protein 2.

CC026_HUMAN
NC score	0.062842 (rank : 97)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	140	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

ECM29_MOUSE
NC score	0.056071 (rank : 98)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	140	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

PIWL3_HUMAN
NC score	0.053937 (rank : 99)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z3Z3	Gene names	PIWIL3
Domain Architecture	No domain graphic available
Description	Piwi-like protein 3.

TBL2_MOUSE
NC score	0.045026 (rank : 100)	θ value	0.0961366 (rank : 73)
Query Neighborhood Hits	140	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R099	Gene names	Tbl2
Domain Architecture
Description	Transducin beta-like 2 protein.

K1914_HUMAN
NC score	0.043860 (rank : 101)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	140	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

K1914_MOUSE
NC score	0.041902 (rank : 102)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	140	Target Neighborhood Hits	216	Shared Neighborhood Hits	4
SwissProt Accessions	Q5DTU0, Q8BID1, Q8K2G0	Gene names	Kiaa1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

GNL1_MOUSE
NC score	0.035027 (rank : 103)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	140	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P36916	Gene names	Gnl1, Gna-rs1, Mmr1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1).

GNL1_HUMAN
NC score	0.029358 (rank : 104)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	140	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P36915	Gene names	GNL1, HSR1
Domain Architecture
Description	Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1).

AN32A_MOUSE
NC score	0.028493 (rank : 105)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	140	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	O35381, P97437	Gene names	Anp32a, Anp32, Lanp
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein).

AN32C_MOUSE
NC score	0.028493 (rank : 106)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	140	Target Neighborhood Hits	254	Shared Neighborhood Hits	8
SwissProt Accessions	Q64G17	Gene names	Anp32c
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C.

AN32E_HUMAN
NC score	0.028267 (rank : 107)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	140	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

CLSPN_HUMAN
NC score	0.027236 (rank : 108)	θ value	1.38821 (rank : 95)
Query Neighborhood Hits	140	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

ENW1_HUMAN
NC score	0.025836 (rank : 109)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	140	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

DVL2_HUMAN
NC score	0.023961 (rank : 110)	θ value	0.62314 (rank : 88)
Query Neighborhood Hits	140	Target Neighborhood Hits	223	Shared Neighborhood Hits	5
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

ISY1_MOUSE
NC score	0.021316 (rank : 111)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	140	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZQ2, Q8VDX4, Q9D3E2	Gene names	Kiaa1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

DVL2_MOUSE
NC score	0.021299 (rank : 112)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	140	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

ISY1_HUMAN
NC score	0.020996 (rank : 113)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

PPM1F_HUMAN
NC score	0.018336 (rank : 114)	θ value	2.36792 (rank : 104)
Query Neighborhood Hits	140	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

TICN2_HUMAN
NC score	0.018253 (rank : 115)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	140	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TBL2_HUMAN
NC score	0.017218 (rank : 116)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	140	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4P3, Q9UQE2	Gene names	TBL2, WBSCR13
Domain Architecture
Description	Transducin beta-like 2 protein (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosome region 13 protein).

ABTAP_MOUSE
NC score	0.016216 (rank : 117)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	140	Target Neighborhood Hits	381	Shared Neighborhood Hits	6
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

HERC2_MOUSE
NC score	0.015132 (rank : 118)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	140	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.014926 (rank : 119)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	140	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

PELP1_MOUSE
NC score	0.014220 (rank : 120)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	140	Target Neighborhood Hits	709	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

MRC2_HUMAN
NC score	0.012501 (rank : 121)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	140	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBG0, Q7LGE7, Q9Y5P9	Gene names	MRC2, ENDO180, KIAA0709, UPARAP
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Urokinase receptor-associated protein) (Endocytic receptor 180) (CD280 antigen).

NKTR_MOUSE
NC score	0.012272 (rank : 122)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	140	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

UBE2W_MOUSE
NC score	0.011801 (rank : 123)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	140	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDW4, Q9D5H3	Gene names	Ube2w
Domain Architecture	No domain graphic available
Description	Probable ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (Ubiquitin- protein ligase W) (Ubiquitin carrier protein W).

MRE11_HUMAN
NC score	0.011543 (rank : 124)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	140	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P49959, O43475	Gene names	MRE11A, HNGS1, MRE11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A).

NU153_HUMAN
NC score	0.011537 (rank : 125)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	140	Target Neighborhood Hits	227	Shared Neighborhood Hits	5
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

YTDC1_HUMAN
NC score	0.011104 (rank : 126)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	140	Target Neighborhood Hits	458	Shared Neighborhood Hits	8
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

UBE2W_HUMAN
NC score	0.010727 (rank : 127)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	140	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q96B02, Q9H823, Q9HAG6, Q9NV07	Gene names	UBE2W
Domain Architecture	No domain graphic available
Description	Probable ubiquitin-conjugating enzyme E2 W (EC 6.3.2.19) (Ubiquitin- protein ligase W) (Ubiquitin carrier protein W).

MRC2_MOUSE
NC score	0.010305 (rank : 128)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	140	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q64449, Q6ZQ64, Q8C6P0	Gene names	Mrc2, Kiaa0709
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Lectin lambda) (CD280 antigen).

ADA19_HUMAN
NC score	0.009490 (rank : 129)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	140	Target Neighborhood Hits	381	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

TSP4_MOUSE
NC score	0.009246 (rank : 130)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	140	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_HUMAN
NC score	0.009235 (rank : 131)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	140	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

PARP9_MOUSE
NC score	0.008045 (rank : 132)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	140	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CAS9, Q99LF9	Gene names	Parp9, Bal
Domain Architecture
Description	Poly [ADP-ribose] polymerase 9 (EC 2.4.2.30) (PARP-9) (B aggressive lymphoma protein homolog).

APBB1_HUMAN
NC score	0.006762 (rank : 133)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	140	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

PDIA4_MOUSE
NC score	0.006464 (rank : 134)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	140	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

DUS3_HUMAN
NC score	0.005572 (rank : 135)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	140	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

KLDC5_MOUSE
NC score	0.005307 (rank : 136)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	140	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFQ9, Q6ZPT4	Gene names	Klhdc5, Kiaa1340
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 5.

DCBD2_HUMAN
NC score	0.004803 (rank : 137)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	140	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PD2, Q8N6M4, Q8TDX2	Gene names	DCBLD2, CLCP1, ESDN
Domain Architecture
Description	Discoidin, CUB and LCCL domain-containing protein 2 precursor (Endothelial and smooth muscle cell-derived neuropilin-like protein) (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1).

CLCN5_MOUSE
NC score	0.004428 (rank : 138)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	140	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVD4	Gene names	Clcn5, Clc5
Domain Architecture
Description	Chloride channel protein 5 (ClC-5).

PRELP_MOUSE
NC score	0.002554 (rank : 139)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	140	Target Neighborhood Hits	295	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JK53	Gene names	Prelp
Domain Architecture
Description	Prolargin precursor (Proline-arginine-rich end leucine-rich repeat protein).

ZN687_MOUSE
NC score	0.002113 (rank : 140)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	140	Target Neighborhood Hits	913	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

SUHW3_MOUSE
NC score	0.001915 (rank : 141)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	140	Target Neighborhood Hits	697	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P3Y5, Q6ZPM2, Q8K145	Gene names	Suhw3, Kiaa1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

NOTC3_MOUSE
NC score	0.001363 (rank : 142)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	140	Target Neighborhood Hits	975	Shared Neighborhood Hits	6
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

PTPRD_MOUSE
NC score	0.000888 (rank : 143)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	140	Target Neighborhood Hits	491	Shared Neighborhood Hits	2
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

ZN687_HUMAN
NC score	0.000870 (rank : 144)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	140	Target Neighborhood Hits	1244	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ANK3_HUMAN
NC score	0.000395 (rank : 145)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	140	Target Neighborhood Hits	853	Shared Neighborhood Hits	7
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ZBTB1_MOUSE
NC score	-0.000713 (rank : 146)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	140	Target Neighborhood Hits	795	Shared Neighborhood Hits	6
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

M3K6_HUMAN
NC score	-0.003421 (rank : 147)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	140	Target Neighborhood Hits	889	Shared Neighborhood Hits	2
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).