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Network neighborhood for query Sequence : DDX58_HUMAN

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DDX58_HUMAN
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDX58_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	105
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
θ value	0 (rank : 2)	NC score	0.984004 (rank : 2)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	62
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

IFIH1_MOUSE
θ value	5.29683e-101 (rank : 3)	NC score	0.895503 (rank : 3)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

IFIH1_HUMAN
θ value	8.75112e-96 (rank : 4)	NC score	0.893349 (rank : 5)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
θ value	4.07447e-85 (rank : 5)	NC score	0.890290 (rank : 6)
Query Neighborhood Hits	105	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

LGP2_HUMAN
θ value	1.35638e-80 (rank : 6)	NC score	0.893766 (rank : 4)
Query Neighborhood Hits	105	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DICER_HUMAN
θ value	4.73814e-25 (rank : 7)	NC score	0.587370 (rank : 8)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
θ value	1.37858e-24 (rank : 8)	NC score	0.587644 (rank : 7)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

FANCM_HUMAN
θ value	1.02238e-19 (rank : 9)	NC score	0.539320 (rank : 10)
Query Neighborhood Hits	105	Target Neighborhood Hits	210	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	1.74391e-19 (rank : 10)	NC score	0.555134 (rank : 9)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

HELC1_HUMAN
θ value	9.29e-05 (rank : 11)	NC score	0.240831 (rank : 11)
Query Neighborhood Hits	105	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

DDX46_HUMAN
θ value	0.000602161 (rank : 12)	NC score	0.218458 (rank : 12)
Query Neighborhood Hits	105	Target Neighborhood Hits	357	Shared Neighborhood Hits	71
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	0.000602161 (rank : 13)	NC score	0.217884 (rank : 13)
Query Neighborhood Hits	105	Target Neighborhood Hits	358	Shared Neighborhood Hits	70
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX23_HUMAN
θ value	0.00102713 (rank : 14)	NC score	0.201476 (rank : 28)
Query Neighborhood Hits	105	Target Neighborhood Hits	486	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX17_HUMAN
θ value	0.00665767 (rank : 15)	NC score	0.212560 (rank : 19)
Query Neighborhood Hits	105	Target Neighborhood Hits	104	Shared Neighborhood Hits	56
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	0.00665767 (rank : 16)	NC score	0.212587 (rank : 18)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	56
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

IF4A2_HUMAN
θ value	0.00869519 (rank : 17)	NC score	0.212946 (rank : 16)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	0.00869519 (rank : 18)	NC score	0.212946 (rank : 17)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A1_HUMAN
θ value	0.0113563 (rank : 19)	NC score	0.215542 (rank : 14)
Query Neighborhood Hits	105	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	0.0113563 (rank : 20)	NC score	0.215542 (rank : 15)
Query Neighborhood Hits	105	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

U520_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.195034 (rank : 39)
Query Neighborhood Hits	105	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

GOGA4_HUMAN
θ value	0.0252991 (rank : 22)	NC score	0.030165 (rank : 99)
Query Neighborhood Hits	105	Target Neighborhood Hits	2034	Shared Neighborhood Hits	35
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

DDX53_HUMAN
θ value	0.0330416 (rank : 23)	NC score	0.182712 (rank : 49)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	55
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX5_HUMAN
θ value	0.0330416 (rank : 24)	NC score	0.208556 (rank : 21)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	0.0330416 (rank : 25)	NC score	0.208740 (rank : 20)
Query Neighborhood Hits	105	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX43_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.198404 (rank : 33)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

MYH11_HUMAN
θ value	0.0736092 (rank : 27)	NC score	0.017738 (rank : 116)
Query Neighborhood Hits	105	Target Neighborhood Hits	1806	Shared Neighborhood Hits	35
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

SMC4_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.028898 (rank : 101)
Query Neighborhood Hits	105	Target Neighborhood Hits	937	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CHD2_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.032487 (rank : 94)
Query Neighborhood Hits	105	Target Neighborhood Hits	360	Shared Neighborhood Hits	22
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

DDX4_MOUSE
θ value	0.0961366 (rank : 30)	NC score	0.204846 (rank : 24)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX4_HUMAN
θ value	0.125558 (rank : 31)	NC score	0.202304 (rank : 26)
Query Neighborhood Hits	105	Target Neighborhood Hits	123	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX56_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.147385 (rank : 75)
Query Neighborhood Hits	105	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX21_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.197706 (rank : 36)
Query Neighborhood Hits	105	Target Neighborhood Hits	308	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX48_HUMAN
θ value	0.365318 (rank : 34)	NC score	0.206004 (rank : 23)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	0.365318 (rank : 35)	NC score	0.206010 (rank : 22)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

CHD1_HUMAN
θ value	0.47712 (rank : 36)	NC score	0.031732 (rank : 95)
Query Neighborhood Hits	105	Target Neighborhood Hits	337	Shared Neighborhood Hits	20
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CHD1_MOUSE
θ value	0.47712 (rank : 37)	NC score	0.031290 (rank : 98)
Query Neighborhood Hits	105	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

DDX18_MOUSE
θ value	0.47712 (rank : 38)	NC score	0.163037 (rank : 57)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX21_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.192333 (rank : 44)
Query Neighborhood Hits	105	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX28_MOUSE
θ value	0.62314 (rank : 40)	NC score	0.176704 (rank : 52)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX3Y_MOUSE
θ value	0.62314 (rank : 41)	NC score	0.200618 (rank : 30)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	58
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX50_MOUSE
θ value	0.813845 (rank : 42)	NC score	0.198415 (rank : 32)
Query Neighborhood Hits	105	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX56_HUMAN
θ value	0.813845 (rank : 43)	NC score	0.147890 (rank : 74)
Query Neighborhood Hits	105	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

PEX5R_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.031509 (rank : 97)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

DDX3X_MOUSE
θ value	1.06291 (rank : 45)	NC score	0.201666 (rank : 27)
Query Neighborhood Hits	105	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.199448 (rank : 31)
Query Neighborhood Hits	105	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX47_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.193650 (rank : 41)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DFFA_MOUSE
θ value	1.06291 (rank : 48)	NC score	0.033563 (rank : 92)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	7
SwissProt Accessions	O54786, O54787	Gene names	Dffa, Icad
Domain Architecture	No domain graphic available
Description	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD).

ANR26_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.015278 (rank : 122)
Query Neighborhood Hits	105	Target Neighborhood Hits	1614	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DDX3X_HUMAN
θ value	1.38821 (rank : 50)	NC score	0.201129 (rank : 29)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	57
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

PRLPI_MOUSE
θ value	1.38821 (rank : 51)	NC score	0.024884 (rank : 107)
Query Neighborhood Hits	105	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUN5, Q5SZY4	Gene names	Prlpi, Prlpj
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein I precursor (PRL-like protein I) (PLP-I) (Decidualin) (Prolactin-like protein J) (PRL-like protein J) (PLP-J).

RB6I2_MOUSE
θ value	1.38821 (rank : 52)	NC score	0.017570 (rank : 117)
Query Neighborhood Hits	105	Target Neighborhood Hits	1433	Shared Neighborhood Hits	30
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

DDX51_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.194360 (rank : 40)
Query Neighborhood Hits	105	Target Neighborhood Hits	332	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX51_MOUSE
θ value	1.81305 (rank : 54)	NC score	0.197067 (rank : 37)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX54_HUMAN
θ value	1.81305 (rank : 55)	NC score	0.159343 (rank : 65)
Query Neighborhood Hits	105	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DESP_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.018494 (rank : 111)
Query Neighborhood Hits	105	Target Neighborhood Hits	1470	Shared Neighborhood Hits	32
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

POLH_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.032606 (rank : 93)
Query Neighborhood Hits	105	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

DDX47_MOUSE
θ value	2.36792 (rank : 58)	NC score	0.192537 (rank : 43)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	57
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX54_MOUSE
θ value	2.36792 (rank : 59)	NC score	0.158761 (rank : 66)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

PEX5R_MOUSE
θ value	2.36792 (rank : 60)	NC score	0.027629 (rank : 104)
Query Neighborhood Hits	105	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C437, Q8CA31, Q9DAA1, Q9JMB9	Gene names	Pex5l, Pex2, Pex5r, Pxr2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

CI039_HUMAN
θ value	3.0926 (rank : 61)	NC score	0.031531 (rank : 96)
Query Neighborhood Hits	105	Target Neighborhood Hits	1171	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CUL3_MOUSE
θ value	3.0926 (rank : 62)	NC score	0.013416 (rank : 125)
Query Neighborhood Hits	105	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

DDX49_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.186251 (rank : 47)
Query Neighborhood Hits	105	Target Neighborhood Hits	223	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX50_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.202711 (rank : 25)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX52_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.197739 (rank : 35)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

ORC6_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.023080 (rank : 108)
Query Neighborhood Hits	105	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUJ8	Gene names	Orc6l, Orc6
Domain Architecture
Description	Origin recognition complex subunit 6.

POLI_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.028664 (rank : 102)
Query Neighborhood Hits	105	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UNA4, Q8N590, Q9H0S1, Q9NYH6	Gene names	POLI, RAD30B
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (RAD30 homolog B) (Eta2).

SPTB1_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.011567 (rank : 129)
Query Neighborhood Hits	105	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

CENPE_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.018594 (rank : 110)
Query Neighborhood Hits	105	Target Neighborhood Hits	2060	Shared Neighborhood Hits	32
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DDX41_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.188008 (rank : 46)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	4.03905 (rank : 71)	NC score	0.188440 (rank : 45)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	61
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

IFT81_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.017892 (rank : 115)
Query Neighborhood Hits	105	Target Neighborhood Hits	893	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

POLI_MOUSE
θ value	4.03905 (rank : 73)	NC score	0.027504 (rank : 105)
Query Neighborhood Hits	105	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	Q6R3M4, Q641P1, Q6R3M3, Q9R1A6	Gene names	Poli, Rad30b
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B).

BTK_HUMAN
θ value	5.27518 (rank : 74)	NC score	-0.002250 (rank : 136)
Query Neighborhood Hits	105	Target Neighborhood Hits	1026	Shared Neighborhood Hits	4
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DDX52_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.198096 (rank : 34)
Query Neighborhood Hits	105	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

MYH9_MOUSE
θ value	5.27518 (rank : 76)	NC score	0.015013 (rank : 123)
Query Neighborhood Hits	105	Target Neighborhood Hits	1829	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

AP3B1_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.005637 (rank : 135)
Query Neighborhood Hits	105	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CCD91_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.015973 (rank : 120)
Query Neighborhood Hits	105	Target Neighborhood Hits	699	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

DDX49_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.180372 (rank : 50)
Query Neighborhood Hits	105	Target Neighborhood Hits	119	Shared Neighborhood Hits	60
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX55_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.172212 (rank : 54)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.169597 (rank : 55)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

HMMR_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.016378 (rank : 119)
Query Neighborhood Hits	105	Target Neighborhood Hits	1178	Shared Neighborhood Hits	28
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

PL10_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.196064 (rank : 38)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

POLH_HUMAN
θ value	6.88961 (rank : 84)	NC score	0.026158 (rank : 106)
Query Neighborhood Hits	105	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y253, Q7L8E3, Q96BC4, Q9BX13	Gene names	POLH, RAD30, RAD30A, XPV
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein).

ROCK1_HUMAN
θ value	6.88961 (rank : 85)	NC score	0.005674 (rank : 133)
Query Neighborhood Hits	105	Target Neighborhood Hits	2000	Shared Neighborhood Hits	30
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.005834 (rank : 132)
Query Neighborhood Hits	105	Target Neighborhood Hits	2126	Shared Neighborhood Hits	31
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SYNE2_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.017968 (rank : 114)
Query Neighborhood Hits	105	Target Neighborhood Hits	1323	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

AQR_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.029936 (rank : 100)
Query Neighborhood Hits	105	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

AQR_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.035421 (rank : 91)
Query Neighborhood Hits	105	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

CHD5_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.027821 (rank : 103)
Query Neighborhood Hits	105	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CI093_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.017152 (rank : 118)
Query Neighborhood Hits	105	Target Neighborhood Hits	1088	Shared Neighborhood Hits	29
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CUL3_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.010721 (rank : 130)
Query Neighborhood Hits	105	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

DDX6_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.161183 (rank : 61)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	8.99809 (rank : 94)	NC score	0.160717 (rank : 62)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

K6PP_MOUSE
θ value	8.99809 (rank : 95)	NC score	0.005662 (rank : 134)
Query Neighborhood Hits	105	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUA3, Q3TNA9, Q3U4P1, Q3U7G4, Q4KUG1, Q543K8, Q8C5I6, Q9JI86	Gene names	Pfkp, Pfkc
Domain Architecture
Description	6-phosphofructokinase type C (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme C) (PFK-C).

MYH9_HUMAN
θ value	8.99809 (rank : 96)	NC score	0.014966 (rank : 124)
Query Neighborhood Hits	105	Target Neighborhood Hits	1762	Shared Neighborhood Hits	32
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PEX6_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.006943 (rank : 131)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

RNF8_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.011854 (rank : 128)
Query Neighborhood Hits	105	Target Neighborhood Hits	622	Shared Neighborhood Hits	23
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

RUFY2_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.013362 (rank : 127)
Query Neighborhood Hits	105	Target Neighborhood Hits	1208	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	8.99809 (rank : 100)	NC score	0.013395 (rank : 126)
Query Neighborhood Hits	105	Target Neighborhood Hits	820	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

SM1L2_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.018415 (rank : 112)
Query Neighborhood Hits	105	Target Neighborhood Hits	1019	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

STIM1_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.018723 (rank : 109)
Query Neighborhood Hits	105	Target Neighborhood Hits	665	Shared Neighborhood Hits	28
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
θ value	8.99809 (rank : 103)	NC score	0.018186 (rank : 113)
Query Neighborhood Hits	105	Target Neighborhood Hits	660	Shared Neighborhood Hits	28
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

TF3A_HUMAN
θ value	8.99809 (rank : 104)	NC score	-0.002864 (rank : 137)
Query Neighborhood Hits	105	Target Neighborhood Hits	726	Shared Neighborhood Hits	3
SwissProt Accessions	Q92664, Q12963, Q13097	Gene names	GTF3A
Domain Architecture	No domain graphic available
Description	Transcription factor IIIA (Factor A) (TFIIIA).

TNNT2_HUMAN
θ value	8.99809 (rank : 105)	NC score	0.015597 (rank : 121)
Query Neighborhood Hits	105	Target Neighborhood Hits	433	Shared Neighborhood Hits	21
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

BLM_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.067117 (rank : 89)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.067841 (rank : 88)
Query Neighborhood Hits	105	Target Neighborhood Hits	108	Shared Neighborhood Hits	42
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

DD19A_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.161726 (rank : 59)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.161968 (rank : 58)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.161397 (rank : 60)
Query Neighborhood Hits	105	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX10_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.146078 (rank : 76)
Query Neighborhood Hits	105	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.144580 (rank : 78)
Query Neighborhood Hits	105	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX18_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.149264 (rank : 73)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.154205 (rank : 70)
Query Neighborhood Hits	105	Target Neighborhood Hits	110	Shared Neighborhood Hits	53
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.155215 (rank : 67)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX20_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.145058 (rank : 77)
Query Neighborhood Hits	105	Target Neighborhood Hits	121	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.144430 (rank : 79)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX24_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.153440 (rank : 71)
Query Neighborhood Hits	105	Target Neighborhood Hits	190	Shared Neighborhood Hits	55
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.151860 (rank : 72)
Query Neighborhood Hits	105	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX25_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.175728 (rank : 53)
Query Neighborhood Hits	105	Target Neighborhood Hits	93	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.178230 (rank : 51)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX27_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.193102 (rank : 42)
Query Neighborhood Hits	105	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.186084 (rank : 48)
Query Neighborhood Hits	105	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX28_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.142802 (rank : 80)
Query Neighborhood Hits	105	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX31_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.159483 (rank : 64)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX39_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.163937 (rank : 56)
Query Neighborhood Hits	105	Target Neighborhood Hits	94	Shared Neighborhood Hits	59
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.160709 (rank : 63)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

RECQ1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.084626 (rank : 84)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	50
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.079563 (rank : 86)
Query Neighborhood Hits	105	Target Neighborhood Hits	95	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ4_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.142028 (rank : 81)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	56
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.130287 (rank : 82)
Query Neighborhood Hits	105	Target Neighborhood Hits	206	Shared Neighborhood Hits	54
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ5_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.086943 (rank : 83)
Query Neighborhood Hits	105	Target Neighborhood Hits	390	Shared Neighborhood Hits	50
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RNC_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.056193 (rank : 90)
Query Neighborhood Hits	105	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

UAP56_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.155168 (rank : 68)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.155098 (rank : 69)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

WRN_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.075358 (rank : 87)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

WRN_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.079847 (rank : 85)
Query Neighborhood Hits	105	Target Neighborhood Hits	295	Shared Neighborhood Hits	55
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

Hits sorted by NC score

DDX58_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	105
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
NC score	0.984004 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	62
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

IFIH1_MOUSE
NC score	0.895503 (rank : 3)	θ value	5.29683e-101 (rank : 3)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
NC score	0.893766 (rank : 4)	θ value	1.35638e-80 (rank : 6)
Query Neighborhood Hits	105	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_HUMAN
NC score	0.893349 (rank : 5)	θ value	8.75112e-96 (rank : 4)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
NC score	0.890290 (rank : 6)	θ value	4.07447e-85 (rank : 5)
Query Neighborhood Hits	105	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

DICER_MOUSE
NC score	0.587644 (rank : 7)	θ value	1.37858e-24 (rank : 8)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
NC score	0.587370 (rank : 8)	θ value	4.73814e-25 (rank : 7)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

FANCM_MOUSE
NC score	0.555134 (rank : 9)	θ value	1.74391e-19 (rank : 10)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

FANCM_HUMAN
NC score	0.539320 (rank : 10)	θ value	1.02238e-19 (rank : 9)
Query Neighborhood Hits	105	Target Neighborhood Hits	210	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

HELC1_HUMAN
NC score	0.240831 (rank : 11)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	105	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

DDX46_HUMAN
NC score	0.218458 (rank : 12)	θ value	0.000602161 (rank : 12)
Query Neighborhood Hits	105	Target Neighborhood Hits	357	Shared Neighborhood Hits	71
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.217884 (rank : 13)	θ value	0.000602161 (rank : 13)
Query Neighborhood Hits	105	Target Neighborhood Hits	358	Shared Neighborhood Hits	70
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

IF4A1_HUMAN
NC score	0.215542 (rank : 14)	θ value	0.0113563 (rank : 19)
Query Neighborhood Hits	105	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.215542 (rank : 15)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	105	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
NC score	0.212946 (rank : 16)	θ value	0.00869519 (rank : 17)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.212946 (rank : 17)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX17_MOUSE
NC score	0.212587 (rank : 18)	θ value	0.00665767 (rank : 16)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	56
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.212560 (rank : 19)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	105	Target Neighborhood Hits	104	Shared Neighborhood Hits	56
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX5_MOUSE
NC score	0.208740 (rank : 20)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	105	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX5_HUMAN
NC score	0.208556 (rank : 21)	θ value	0.0330416 (rank : 24)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX48_MOUSE
NC score	0.206010 (rank : 22)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX48_HUMAN
NC score	0.206004 (rank : 23)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	56
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX4_MOUSE
NC score	0.204846 (rank : 24)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX50_HUMAN
NC score	0.202711 (rank : 25)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX4_HUMAN
NC score	0.202304 (rank : 26)	θ value	0.125558 (rank : 31)
Query Neighborhood Hits	105	Target Neighborhood Hits	123	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX3X_MOUSE
NC score	0.201666 (rank : 27)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	105	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX23_HUMAN
NC score	0.201476 (rank : 28)	θ value	0.00102713 (rank : 14)
Query Neighborhood Hits	105	Target Neighborhood Hits	486	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX3X_HUMAN
NC score	0.201129 (rank : 29)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	57
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3Y_MOUSE
NC score	0.200618 (rank : 30)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	105	Target Neighborhood Hits	126	Shared Neighborhood Hits	58
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX3Y_HUMAN
NC score	0.199448 (rank : 31)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	105	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX50_MOUSE
NC score	0.198415 (rank : 32)	θ value	0.813845 (rank : 42)
Query Neighborhood Hits	105	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX43_HUMAN
NC score	0.198404 (rank : 33)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX52_MOUSE
NC score	0.198096 (rank : 34)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	105	Target Neighborhood Hits	101	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_HUMAN
NC score	0.197739 (rank : 35)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX21_HUMAN
NC score	0.197706 (rank : 36)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	105	Target Neighborhood Hits	308	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX51_MOUSE
NC score	0.197067 (rank : 37)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

PL10_MOUSE
NC score	0.196064 (rank : 38)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	57
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

U520_HUMAN
NC score	0.195034 (rank : 39)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	105	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

DDX51_HUMAN
NC score	0.194360 (rank : 40)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	105	Target Neighborhood Hits	332	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX47_HUMAN
NC score	0.193650 (rank : 41)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX27_HUMAN
NC score	0.193102 (rank : 42)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	105	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX47_MOUSE
NC score	0.192537 (rank : 43)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	57
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX21_MOUSE
NC score	0.192333 (rank : 44)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	105	Target Neighborhood Hits	350	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX41_MOUSE
NC score	0.188440 (rank : 45)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	61
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX41_HUMAN
NC score	0.188008 (rank : 46)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX49_HUMAN
NC score	0.186251 (rank : 47)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	105	Target Neighborhood Hits	223	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_MOUSE
NC score	0.186084 (rank : 48)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	105	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX53_HUMAN
NC score	0.182712 (rank : 49)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	55
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX49_MOUSE
NC score	0.180372 (rank : 50)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	105	Target Neighborhood Hits	119	Shared Neighborhood Hits	60
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX25_MOUSE
NC score	0.178230 (rank : 51)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX28_MOUSE
NC score	0.176704 (rank : 52)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX25_HUMAN
NC score	0.175728 (rank : 53)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	105	Target Neighborhood Hits	93	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX55_HUMAN
NC score	0.172212 (rank : 54)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
NC score	0.169597 (rank : 55)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	57
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX39_HUMAN
NC score	0.163937 (rank : 56)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	105	Target Neighborhood Hits	94	Shared Neighborhood Hits	59
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX18_MOUSE
NC score	0.163037 (rank : 57)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DD19A_MOUSE
NC score	0.161968 (rank : 58)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19A_HUMAN
NC score	0.161726 (rank : 59)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
NC score	0.161397 (rank : 60)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	105	Target Neighborhood Hits	109	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX6_HUMAN
NC score	0.161183 (rank : 61)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.160717 (rank : 62)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX39_MOUSE
NC score	0.160709 (rank : 63)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	105	Target Neighborhood Hits	97	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX31_HUMAN
NC score	0.159483 (rank : 64)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX54_HUMAN
NC score	0.159343 (rank : 65)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	105	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX54_MOUSE
NC score	0.158761 (rank : 66)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX1_MOUSE
NC score	0.155215 (rank : 67)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

UAP56_HUMAN
NC score	0.155168 (rank : 68)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.155098 (rank : 69)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	105	Target Neighborhood Hits	96	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX1_HUMAN
NC score	0.154205 (rank : 70)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	105	Target Neighborhood Hits	110	Shared Neighborhood Hits	53
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX24_HUMAN
NC score	0.153440 (rank : 71)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	105	Target Neighborhood Hits	190	Shared Neighborhood Hits	55
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
NC score	0.151860 (rank : 72)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	105	Target Neighborhood Hits	147	Shared Neighborhood Hits	56
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX18_HUMAN
NC score	0.149264 (rank : 73)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX56_HUMAN
NC score	0.147890 (rank : 74)	θ value	0.813845 (rank : 43)
Query Neighborhood Hits	105	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
NC score	0.147385 (rank : 75)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	105	Target Neighborhood Hits	87	Shared Neighborhood Hits	50
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX10_HUMAN
NC score	0.146078 (rank : 76)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	105	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX20_HUMAN
NC score	0.145058 (rank : 77)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	105	Target Neighborhood Hits	121	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX10_MOUSE
NC score	0.144580 (rank : 78)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	105	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX20_MOUSE
NC score	0.144430 (rank : 79)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX28_HUMAN
NC score	0.142802 (rank : 80)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	105	Target Neighborhood Hits	103	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

RECQ4_HUMAN
NC score	0.142028 (rank : 81)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	105	Target Neighborhood Hits	177	Shared Neighborhood Hits	56
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.130287 (rank : 82)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	105	Target Neighborhood Hits	206	Shared Neighborhood Hits	54
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ5_HUMAN
NC score	0.086943 (rank : 83)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	105	Target Neighborhood Hits	390	Shared Neighborhood Hits	50
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RECQ1_HUMAN
NC score	0.084626 (rank : 84)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	50
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

WRN_MOUSE
NC score	0.079847 (rank : 85)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	105	Target Neighborhood Hits	295	Shared Neighborhood Hits	55
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ1_MOUSE
NC score	0.079563 (rank : 86)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	105	Target Neighborhood Hits	95	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

WRN_HUMAN
NC score	0.075358 (rank : 87)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

BLM_MOUSE
NC score	0.067841 (rank : 88)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	105	Target Neighborhood Hits	108	Shared Neighborhood Hits	42
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.067117 (rank : 89)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RNC_HUMAN
NC score	0.056193 (rank : 90)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	105	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

AQR_MOUSE
NC score	0.035421 (rank : 91)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	105	Target Neighborhood Hits	62	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

DFFA_MOUSE
NC score	0.033563 (rank : 92)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	105	Target Neighborhood Hits	100	Shared Neighborhood Hits	7
SwissProt Accessions	O54786, O54787	Gene names	Dffa, Icad
Domain Architecture	No domain graphic available
Description	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD).

POLH_MOUSE
NC score	0.032606 (rank : 93)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	105	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

CHD2_HUMAN
NC score	0.032487 (rank : 94)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	105	Target Neighborhood Hits	360	Shared Neighborhood Hits	22
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

CHD1_HUMAN
NC score	0.031732 (rank : 95)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	105	Target Neighborhood Hits	337	Shared Neighborhood Hits	20
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CI039_HUMAN
NC score	0.031531 (rank : 96)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	105	Target Neighborhood Hits	1171	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

PEX5R_HUMAN
NC score	0.031509 (rank : 97)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	105	Target Neighborhood Hits	102	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

CHD1_MOUSE
NC score	0.031290 (rank : 98)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	105	Target Neighborhood Hits	266	Shared Neighborhood Hits	17
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

GOGA4_HUMAN
NC score	0.030165 (rank : 99)	θ value	0.0252991 (rank : 22)
Query Neighborhood Hits	105	Target Neighborhood Hits	2034	Shared Neighborhood Hits	35
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

AQR_HUMAN
NC score	0.029936 (rank : 100)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	105	Target Neighborhood Hits	88	Shared Neighborhood Hits	7
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

SMC4_HUMAN
NC score	0.028898 (rank : 101)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	105	Target Neighborhood Hits	937	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

POLI_HUMAN
NC score	0.028664 (rank : 102)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	105	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UNA4, Q8N590, Q9H0S1, Q9NYH6	Gene names	POLI, RAD30B
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (RAD30 homolog B) (Eta2).

CHD5_HUMAN
NC score	0.027821 (rank : 103)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	105	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

PEX5R_MOUSE
NC score	0.027629 (rank : 104)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	105	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C437, Q8CA31, Q9DAA1, Q9JMB9	Gene names	Pex5l, Pex2, Pex5r, Pxr2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

POLI_MOUSE
NC score	0.027504 (rank : 105)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	105	Target Neighborhood Hits	27	Shared Neighborhood Hits	5
SwissProt Accessions	Q6R3M4, Q641P1, Q6R3M3, Q9R1A6	Gene names	Poli, Rad30b
Domain Architecture	No domain graphic available
Description	DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B).

POLH_HUMAN
NC score	0.026158 (rank : 106)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	105	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y253, Q7L8E3, Q96BC4, Q9BX13	Gene names	POLH, RAD30, RAD30A, XPV
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein).

PRLPI_MOUSE
NC score	0.024884 (rank : 107)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	105	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUN5, Q5SZY4	Gene names	Prlpi, Prlpj
Domain Architecture	No domain graphic available
Description	Placental prolactin-like protein I precursor (PRL-like protein I) (PLP-I) (Decidualin) (Prolactin-like protein J) (PRL-like protein J) (PLP-J).

ORC6_MOUSE
NC score	0.023080 (rank : 108)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	105	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUJ8	Gene names	Orc6l, Orc6
Domain Architecture
Description	Origin recognition complex subunit 6.

STIM1_HUMAN
NC score	0.018723 (rank : 109)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	105	Target Neighborhood Hits	665	Shared Neighborhood Hits	28
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

CENPE_HUMAN
NC score	0.018594 (rank : 110)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	105	Target Neighborhood Hits	2060	Shared Neighborhood Hits	32
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DESP_HUMAN
NC score	0.018494 (rank : 111)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	105	Target Neighborhood Hits	1470	Shared Neighborhood Hits	32
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

SM1L2_HUMAN
NC score	0.018415 (rank : 112)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	105	Target Neighborhood Hits	1019	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

STIM1_MOUSE
NC score	0.018186 (rank : 113)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	105	Target Neighborhood Hits	660	Shared Neighborhood Hits	28
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

SYNE2_HUMAN
NC score	0.017968 (rank : 114)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	105	Target Neighborhood Hits	1323	Shared Neighborhood Hits	29
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

IFT81_HUMAN
NC score	0.017892 (rank : 115)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	105	Target Neighborhood Hits	893	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

MYH11_HUMAN
NC score	0.017738 (rank : 116)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	105	Target Neighborhood Hits	1806	Shared Neighborhood Hits	35
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

RB6I2_MOUSE
NC score	0.017570 (rank : 117)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	105	Target Neighborhood Hits	1433	Shared Neighborhood Hits	30
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

CI093_HUMAN
NC score	0.017152 (rank : 118)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	105	Target Neighborhood Hits	1088	Shared Neighborhood Hits	29
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

HMMR_MOUSE
NC score	0.016378 (rank : 119)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	105	Target Neighborhood Hits	1178	Shared Neighborhood Hits	28
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

CCD91_MOUSE
NC score	0.015973 (rank : 120)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	105	Target Neighborhood Hits	699	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

TNNT2_HUMAN
NC score	0.015597 (rank : 121)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	105	Target Neighborhood Hits	433	Shared Neighborhood Hits	21
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

ANR26_HUMAN
NC score	0.015278 (rank : 122)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	105	Target Neighborhood Hits	1614	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

MYH9_MOUSE
NC score	0.015013 (rank : 123)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	105	Target Neighborhood Hits	1829	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_HUMAN
NC score	0.014966 (rank : 124)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	105	Target Neighborhood Hits	1762	Shared Neighborhood Hits	32
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CUL3_MOUSE
NC score	0.013416 (rank : 125)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	105	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JLV5	Gene names	Cul3
Domain Architecture
Description	Cullin-3 (CUL-3).

RUFY2_MOUSE
NC score	0.013395 (rank : 126)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	105	Target Neighborhood Hits	820	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY2_HUMAN
NC score	0.013362 (rank : 127)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	105	Target Neighborhood Hits	1208	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RNF8_HUMAN
NC score	0.011854 (rank : 128)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	105	Target Neighborhood Hits	622	Shared Neighborhood Hits	23
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

SPTB1_MOUSE
NC score	0.011567 (rank : 129)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	105	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

CUL3_HUMAN
NC score	0.010721 (rank : 130)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	105	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q13618, O75415, Q569L3, Q9UBI8, Q9UET7	Gene names	CUL3, KIAA0617
Domain Architecture
Description	Cullin-3 (CUL-3).

PEX6_HUMAN
NC score	0.006943 (rank : 131)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

ROCK1_MOUSE
NC score	0.005834 (rank : 132)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	105	Target Neighborhood Hits	2126	Shared Neighborhood Hits	31
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK1_HUMAN
NC score	0.005674 (rank : 133)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	105	Target Neighborhood Hits	2000	Shared Neighborhood Hits	30
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

K6PP_MOUSE
NC score	0.005662 (rank : 134)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	105	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUA3, Q3TNA9, Q3U4P1, Q3U7G4, Q4KUG1, Q543K8, Q8C5I6, Q9JI86	Gene names	Pfkp, Pfkc
Domain Architecture
Description	6-phosphofructokinase type C (EC 2.7.1.11) (Phosphofructokinase 1) (Phosphohexokinase) (Phosphofructo-1-kinase isozyme C) (PFK-C).

AP3B1_MOUSE
NC score	0.005637 (rank : 135)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	105	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

BTK_HUMAN
NC score	-0.002250 (rank : 136)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	105	Target Neighborhood Hits	1026	Shared Neighborhood Hits	4
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

TF3A_HUMAN
NC score	-0.002864 (rank : 137)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	105	Target Neighborhood Hits	726	Shared Neighborhood Hits	3
SwissProt Accessions	Q92664, Q12963, Q13097	Gene names	GTF3A
Domain Architecture	No domain graphic available
Description	Transcription factor IIIA (Factor A) (TFIIIA).