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Network neighborhood for query Sequence : FANCM_MOUSE

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FANCM_MOUSE
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FANCM_HUMAN
θ value	0 (rank : 1)	NC score	0.964189 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	94
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

DDX58_MOUSE
θ value	3.39556e-23 (rank : 3)	NC score	0.569715 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	99	Shared Neighborhood Hits	61
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
θ value	1.74391e-19 (rank : 4)	NC score	0.555134 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

IFIH1_MOUSE
θ value	2.35696e-16 (rank : 5)	NC score	0.556426 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
θ value	6.00763e-12 (rank : 6)	NC score	0.554999 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_HUMAN
θ value	1.33837e-11 (rank : 7)	NC score	0.549865 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

ERCC4_HUMAN
θ value	8.67504e-11 (rank : 8)	NC score	0.281698 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q92889, O00140, Q8TD83	Gene names	ERCC4, ERCC11, XPF
Domain Architecture
Description	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA-repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein).

LGP2_MOUSE
θ value	2.52405e-10 (rank : 9)	NC score	0.549159 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	68
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

DICER_HUMAN
θ value	2.79066e-09 (rank : 10)	NC score	0.490041 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
θ value	6.21693e-09 (rank : 11)	NC score	0.487765 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DDX21_MOUSE
θ value	9.92553e-07 (rank : 12)	NC score	0.454804 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX21_HUMAN
θ value	2.21117e-06 (rank : 13)	NC score	0.459090 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

ERCC4_MOUSE
θ value	2.88788e-06 (rank : 14)	NC score	0.244332 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QZD4, O54810, Q8R0I3	Gene names	Ercc4
Domain Architecture
Description	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4).

DDX50_MOUSE
θ value	8.40245e-06 (rank : 15)	NC score	0.457689 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_HUMAN
θ value	1.09739e-05 (rank : 16)	NC score	0.459614 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX27_MOUSE
θ value	1.43324e-05 (rank : 17)	NC score	0.451694 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	82
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX48_HUMAN
θ value	1.43324e-05 (rank : 18)	NC score	0.449249 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	1.43324e-05 (rank : 19)	NC score	0.449229 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX51_HUMAN
θ value	1.87187e-05 (rank : 20)	NC score	0.448608 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX18_HUMAN
θ value	4.1701e-05 (rank : 21)	NC score	0.433332 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX41_HUMAN
θ value	4.1701e-05 (rank : 22)	NC score	0.444921 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	4.1701e-05 (rank : 23)	NC score	0.445981 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX27_HUMAN
θ value	7.1131e-05 (rank : 24)	NC score	0.453489 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	84
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX3Y_MOUSE
θ value	7.1131e-05 (rank : 25)	NC score	0.444762 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX4_HUMAN
θ value	7.1131e-05 (rank : 26)	NC score	0.446332 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	123	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX4_MOUSE
θ value	7.1131e-05 (rank : 27)	NC score	0.447961 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	80
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

IF4A1_HUMAN
θ value	7.1131e-05 (rank : 28)	NC score	0.445975 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	7.1131e-05 (rank : 29)	NC score	0.445975 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX18_MOUSE
θ value	9.29e-05 (rank : 30)	NC score	0.436383 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX31_HUMAN
θ value	9.29e-05 (rank : 31)	NC score	0.429588 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX51_MOUSE
θ value	9.29e-05 (rank : 32)	NC score	0.452191 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	130	Shared Neighborhood Hits	80
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

HELC1_HUMAN
θ value	9.29e-05 (rank : 33)	NC score	0.235411 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

DDX3X_HUMAN
θ value	0.000158464 (rank : 34)	NC score	0.443991 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	80
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	0.000158464 (rank : 35)	NC score	0.444098 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	80
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

PL10_MOUSE
θ value	0.000158464 (rank : 36)	NC score	0.442491 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	80
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3Y_HUMAN
θ value	0.00020696 (rank : 37)	NC score	0.442555 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	79
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX49_MOUSE
θ value	0.00020696 (rank : 38)	NC score	0.437378 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

IF4A2_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.443856 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	0.00020696 (rank : 40)	NC score	0.443856 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX49_HUMAN
θ value	0.000270298 (rank : 41)	NC score	0.436728 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	223	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX6_HUMAN
θ value	0.000270298 (rank : 42)	NC score	0.426125 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	0.000270298 (rank : 43)	NC score	0.425845 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX52_MOUSE
θ value	0.00035302 (rank : 44)	NC score	0.445310 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_HUMAN
θ value	0.000461057 (rank : 45)	NC score	0.444372 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	107	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

CHD5_HUMAN
θ value	0.000602161 (rank : 46)	NC score	0.075268 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	349	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

DDX10_MOUSE
θ value	0.000602161 (rank : 47)	NC score	0.420655 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	233	Shared Neighborhood Hits	75
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_HUMAN
θ value	0.00175202 (rank : 48)	NC score	0.419907 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	78
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX17_HUMAN
θ value	0.00298849 (rank : 49)	NC score	0.433014 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	0.00298849 (rank : 50)	NC score	0.432998 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX25_HUMAN
θ value	0.00298849 (rank : 51)	NC score	0.423102 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	0.00390308 (rank : 52)	NC score	0.423774 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX5_HUMAN
θ value	0.00390308 (rank : 53)	NC score	0.428950 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	0.00390308 (rank : 54)	NC score	0.428911 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	77
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX39_MOUSE
θ value	0.00509761 (rank : 55)	NC score	0.421133 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX47_HUMAN
θ value	0.00509761 (rank : 56)	NC score	0.432459 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	0.00509761 (rank : 57)	NC score	0.432335 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX1_HUMAN
θ value	0.00665767 (rank : 58)	NC score	0.402175 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	110	Shared Neighborhood Hits	73
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX39_HUMAN
θ value	0.00665767 (rank : 59)	NC score	0.422161 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	76
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

MAP1B_HUMAN
θ value	0.00665767 (rank : 60)	NC score	0.047220 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	903	Shared Neighborhood Hits	29
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

CHD3_HUMAN
θ value	0.00869519 (rank : 61)	NC score	0.067063 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	397	Shared Neighborhood Hits	33
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

DDX23_HUMAN
θ value	0.00869519 (rank : 62)	NC score	0.421075 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	486	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

U520_HUMAN
θ value	0.00869519 (rank : 63)	NC score	0.200565 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	38
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

DDX1_MOUSE
θ value	0.0148317 (rank : 64)	NC score	0.402259 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	112	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX43_HUMAN
θ value	0.0193708 (rank : 65)	NC score	0.429135 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX55_MOUSE
θ value	0.0193708 (rank : 66)	NC score	0.424093 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

BTAF1_HUMAN
θ value	0.0252991 (rank : 67)	NC score	0.064693 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

DDX46_HUMAN
θ value	0.0252991 (rank : 68)	NC score	0.425517 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	357	Shared Neighborhood Hits	93
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	0.0252991 (rank : 69)	NC score	0.424162 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	91
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

UAP56_HUMAN
θ value	0.0252991 (rank : 70)	NC score	0.415178 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	0.0252991 (rank : 71)	NC score	0.415135 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX28_MOUSE
θ value	0.0330416 (rank : 72)	NC score	0.416060 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	112	Shared Neighborhood Hits	80
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

STAG1_HUMAN
θ value	0.0330416 (rank : 73)	NC score	0.053707 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

DD19A_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.414556 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	107	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	0.0431538 (rank : 75)	NC score	0.414765 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	0.0431538 (rank : 76)	NC score	0.414203 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX55_HUMAN
θ value	0.0431538 (rank : 77)	NC score	0.420822 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

NFH_HUMAN
θ value	0.0431538 (rank : 78)	NC score	0.022756 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	1242	Shared Neighborhood Hits	44
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DDX24_MOUSE
θ value	0.0563607 (rank : 79)	NC score	0.406289 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

RECQ5_HUMAN
θ value	0.0563607 (rank : 80)	NC score	0.228515 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	79
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

DDX24_HUMAN
θ value	0.0736092 (rank : 81)	NC score	0.404540 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	81
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

STAG1_MOUSE
θ value	0.0736092 (rank : 82)	NC score	0.052111 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

DNL1_HUMAN
θ value	0.0961366 (rank : 83)	NC score	0.043561 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	216	Shared Neighborhood Hits	14
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

ATRX_HUMAN
θ value	0.125558 (rank : 84)	NC score	0.070402 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	842	Shared Neighborhood Hits	49
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

DDX20_MOUSE
θ value	0.125558 (rank : 85)	NC score	0.403114 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

MYH10_HUMAN
θ value	0.125558 (rank : 86)	NC score	0.013536 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	1620	Shared Neighborhood Hits	25
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

DDX53_HUMAN
θ value	0.163984 (rank : 87)	NC score	0.411806 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	76
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

MYH10_MOUSE
θ value	0.163984 (rank : 88)	NC score	0.013641 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	1612	Shared Neighborhood Hits	27
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NRBF2_MOUSE
θ value	0.163984 (rank : 89)	NC score	0.060648 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCQ3, Q9DCG3	Gene names	Nrbf2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2).

DDX20_HUMAN
θ value	0.21417 (rank : 90)	NC score	0.403728 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

CO3_HUMAN
θ value	0.279714 (rank : 91)	NC score	0.030492 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

FILA_HUMAN
θ value	0.279714 (rank : 92)	NC score	0.039312 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	685	Shared Neighborhood Hits	26
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SPAG1_HUMAN
θ value	0.279714 (rank : 93)	NC score	0.025384 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q07617, Q7Z5G1	Gene names	SPAG1
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (HSD-3.8).

AQR_HUMAN
θ value	0.365318 (rank : 94)	NC score	0.064866 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

AQR_MOUSE
θ value	0.365318 (rank : 95)	NC score	0.067310 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

HXC12_HUMAN
θ value	0.47712 (rank : 96)	NC score	0.014966 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	4
SwissProt Accessions	P31275, Q9BXJ6	Gene names	HOXC12, HOX3F
Domain Architecture
Description	Homeobox protein Hox-C12 (Hox-3F).

CLSPN_HUMAN
θ value	0.62314 (rank : 97)	NC score	0.051176 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

ENL_HUMAN
θ value	0.62314 (rank : 98)	NC score	0.039387 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	21
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

LYST_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.017935 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

RECQ4_HUMAN
θ value	0.813845 (rank : 100)	NC score	0.275284 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

ATRX_MOUSE
θ value	1.06291 (rank : 101)	NC score	0.062880 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	682	Shared Neighborhood Hits	40
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

HXC12_MOUSE
θ value	1.06291 (rank : 102)	NC score	0.013185 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

MYCB2_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.030907 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	14
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

SPRL1_MOUSE
θ value	1.06291 (rank : 104)	NC score	0.026724 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	21
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

CO3_MOUSE
θ value	1.38821 (rank : 105)	NC score	0.026071 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P01027, Q61370	Gene names	C3
Domain Architecture
Description	Complement C3 precursor (HSE-MSF) [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3, isoform Short; Complement C3f fragment].

GNPTA_MOUSE
θ value	1.38821 (rank : 106)	NC score	0.024246 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

MLL3_HUMAN
θ value	1.38821 (rank : 107)	NC score	0.017941 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	1644	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PSTK_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.033424 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IV42, Q6ZSS9	Gene names	PSTK, C10orf89
Domain Architecture	No domain graphic available
Description	L-seryl-tRNA(Ser/Sec) kinase (EC 2.7.1.-) (Phosphoseryl-tRNA(Ser/Sec) kinase).

RIOK1_HUMAN
θ value	1.38821 (rank : 109)	NC score	0.028713 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

TCEA1_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.019278 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	P23193, Q15563, Q6FG87	Gene names	TCEA1, TFIIS
Domain Architecture
Description	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o).

DZIP1_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.022169 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	675	Shared Neighborhood Hits	17
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

HIRP3_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.036796 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	323	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

INADL_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.009568 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	7
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

IWS1_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.044574 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYCB2_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.028307 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

PCLO_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.014294 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	2275	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PHF22_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.031840 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

RAD54_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.050614 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q92698, Q6IUY3	Gene names	RAD54L, RAD54A
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (hRAD54) (hHR54).

RAD54_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.051169 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	P70270, Q8BSR5, Q8C2C4, Q8K3D4	Gene names	Rad54l, Rad54
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (mRAD54) (mHR54).

TCOF_HUMAN
θ value	1.81305 (rank : 120)	NC score	0.036264 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	25
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

WRN_MOUSE
θ value	1.81305 (rank : 121)	NC score	0.198269 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	295	Shared Neighborhood Hits	75
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

CENPC_HUMAN
θ value	2.36792 (rank : 122)	NC score	0.029310 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	16
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

ZFP91_MOUSE
θ value	2.36792 (rank : 123)	NC score	-0.000865 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	742	Shared Neighborhood Hits	6
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

CO039_MOUSE
θ value	3.0926 (rank : 124)	NC score	0.019137 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

FLIP1_MOUSE
θ value	3.0926 (rank : 125)	NC score	0.009490 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	1176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

LN28B_MOUSE
θ value	3.0926 (rank : 126)	NC score	0.017309 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q45KJ6, Q3UZC6, Q3V444	Gene names	Lin28b
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

MSPD2_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.023472 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	52	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NHP6, Q8N3H2, Q8NA83	Gene names	MOSPD2
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 2.

MYH9_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.012736 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	1762	Shared Neighborhood Hits	39
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NMDE1_MOUSE
θ value	3.0926 (rank : 129)	NC score	0.010450 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

NRBF2_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.044121 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

PDXL2_MOUSE
θ value	3.0926 (rank : 131)	NC score	0.021221 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

STAG3_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.038595 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

CI082_MOUSE
θ value	4.03905 (rank : 133)	NC score	0.021412 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDY9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf82 homolog.

ICAL_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.030375 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	275	Shared Neighborhood Hits	21
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

K1718_HUMAN
θ value	4.03905 (rank : 135)	NC score	0.012302 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

MY18A_MOUSE
θ value	4.03905 (rank : 136)	NC score	0.014987 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	1989	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NMDE1_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.010079 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

ZCH11_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.029972 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

ZFP91_HUMAN
θ value	4.03905 (rank : 139)	NC score	-0.000821 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	769	Shared Neighborhood Hits	9
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

CSPG3_HUMAN
θ value	5.27518 (rank : 140)	NC score	0.002529 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DPOD3_HUMAN
θ value	5.27518 (rank : 141)	NC score	0.027961 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

FRS2_HUMAN
θ value	5.27518 (rank : 142)	NC score	0.011774 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

M3K5_MOUSE
θ value	5.27518 (rank : 143)	NC score	-0.004368 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	5
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

NFH_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.017528 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	2247	Shared Neighborhood Hits	50
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

OTC_MOUSE
θ value	5.27518 (rank : 145)	NC score	0.016877 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

PHF14_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.020703 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PSIP1_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.016501 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	17
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

TIM_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.014851 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

TXND2_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.043422 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	828	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

VAPB_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.016769 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

ABTAP_MOUSE
θ value	6.88961 (rank : 151)	NC score	0.017906 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	381	Shared Neighborhood Hits	21
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

ACM5_HUMAN
θ value	6.88961 (rank : 152)	NC score	-0.003157 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	878	Shared Neighborhood Hits	2
SwissProt Accessions	P08912, Q96RG7	Gene names	CHRM5
Domain Architecture
Description	Muscarinic acetylcholine receptor M5.

CLMN_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.008554 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

CTND1_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.010180 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CTND2_MOUSE
θ value	6.88961 (rank : 155)	NC score	0.010817 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

DDX28_HUMAN
θ value	6.88961 (rank : 156)	NC score	0.387134 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	103	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

JHD1B_MOUSE
θ value	6.88961 (rank : 157)	NC score	0.010012 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

NU153_HUMAN
θ value	6.88961 (rank : 158)	NC score	0.012665 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

NUAK1_MOUSE
θ value	6.88961 (rank : 159)	NC score	-0.005187 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	881	Shared Neighborhood Hits	6
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

P55G_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.006535 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	9
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PAX3_MOUSE
θ value	6.88961 (rank : 161)	NC score	0.001086 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	478	Shared Neighborhood Hits	5
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

PKCB1_HUMAN
θ value	6.88961 (rank : 162)	NC score	0.042142 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	488	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

TM131_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.020022 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	O70472	Gene names	Tmem131, D1Bwg0491e, Rw1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 131 (Protein RW1).

ARD1_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.001295 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	621	Shared Neighborhood Hits	4
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

ARD1_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.001703 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	573	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

BCLF1_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.016480 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	298	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

CTND2_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.009489 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	333	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

GCC2_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.007013 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	1619	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

LRP5_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.001873 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	224	Shared Neighborhood Hits	2
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

MYPC2_MOUSE
θ value	8.99809 (rank : 170)	NC score	0.001744 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

NPM_MOUSE
θ value	8.99809 (rank : 171)	NC score	0.013620 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q61937	Gene names	Npm1
Domain Architecture
Description	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38).

PCLO_HUMAN
θ value	8.99809 (rank : 172)	NC score	0.016089 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PHF14_MOUSE
θ value	8.99809 (rank : 173)	NC score	0.018545 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

SF3B3_HUMAN
θ value	8.99809 (rank : 174)	NC score	0.012300 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

SFR12_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.008571 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	553	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

THAP7_HUMAN
θ value	8.99809 (rank : 176)	NC score	0.011158 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BT49	Gene names	THAP7
Domain Architecture
Description	THAP domain-containing protein 7.

UBP53_MOUSE
θ value	8.99809 (rank : 177)	NC score	0.011504 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

BLM_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.191827 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.196929 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	108	Shared Neighborhood Hits	64
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

CC026_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.070846 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

CHD4_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.053097 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	365	Shared Neighborhood Hits	41
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.053444 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	408	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

DDX54_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.382449 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX54_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.384397 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX56_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.375242 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.374835 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

RECQ1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.184901 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.182738 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ4_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.236610 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

SMAL1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.058700 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SMCA1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.050357 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

WRN_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.203050 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

Hits sorted by NC score

FANCM_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	177
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

FANCM_HUMAN
NC score	0.964189 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	94
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

DDX58_MOUSE
NC score	0.569715 (rank : 3)	θ value	3.39556e-23 (rank : 3)
Query Neighborhood Hits	177	Target Neighborhood Hits	99	Shared Neighborhood Hits	61
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

IFIH1_MOUSE
NC score	0.556426 (rank : 4)	θ value	2.35696e-16 (rank : 5)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DDX58_HUMAN
NC score	0.555134 (rank : 5)	θ value	1.74391e-19 (rank : 4)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	58
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

LGP2_HUMAN
NC score	0.554999 (rank : 6)	θ value	6.00763e-12 (rank : 6)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_HUMAN
NC score	0.549865 (rank : 7)	θ value	1.33837e-11 (rank : 7)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
NC score	0.549159 (rank : 8)	θ value	2.52405e-10 (rank : 9)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	68
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

DICER_HUMAN
NC score	0.490041 (rank : 9)	θ value	2.79066e-09 (rank : 10)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.487765 (rank : 10)	θ value	6.21693e-09 (rank : 11)
Query Neighborhood Hits	177	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DDX50_HUMAN
NC score	0.459614 (rank : 11)	θ value	1.09739e-05 (rank : 16)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX21_HUMAN
NC score	0.459090 (rank : 12)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	177	Target Neighborhood Hits	308	Shared Neighborhood Hits	93
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX50_MOUSE
NC score	0.457689 (rank : 13)	θ value	8.40245e-06 (rank : 15)
Query Neighborhood Hits	177	Target Neighborhood Hits	137	Shared Neighborhood Hits	79
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX21_MOUSE
NC score	0.454804 (rank : 14)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	177	Target Neighborhood Hits	350	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX27_HUMAN
NC score	0.453489 (rank : 15)	θ value	7.1131e-05 (rank : 24)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	84
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX51_MOUSE
NC score	0.452191 (rank : 16)	θ value	9.29e-05 (rank : 32)
Query Neighborhood Hits	177	Target Neighborhood Hits	130	Shared Neighborhood Hits	80
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX27_MOUSE
NC score	0.451694 (rank : 17)	θ value	1.43324e-05 (rank : 17)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	82
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX48_HUMAN
NC score	0.449249 (rank : 18)	θ value	1.43324e-05 (rank : 18)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.449229 (rank : 19)	θ value	1.43324e-05 (rank : 19)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX51_HUMAN
NC score	0.448608 (rank : 20)	θ value	1.87187e-05 (rank : 20)
Query Neighborhood Hits	177	Target Neighborhood Hits	332	Shared Neighborhood Hits	84
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX4_MOUSE
NC score	0.447961 (rank : 21)	θ value	7.1131e-05 (rank : 27)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	80
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX4_HUMAN
NC score	0.446332 (rank : 22)	θ value	7.1131e-05 (rank : 26)
Query Neighborhood Hits	177	Target Neighborhood Hits	123	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX41_MOUSE
NC score	0.445981 (rank : 23)	θ value	4.1701e-05 (rank : 23)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

IF4A1_HUMAN
NC score	0.445975 (rank : 24)	θ value	7.1131e-05 (rank : 28)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.445975 (rank : 25)	θ value	7.1131e-05 (rank : 29)
Query Neighborhood Hits	177	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX52_MOUSE
NC score	0.445310 (rank : 26)	θ value	0.00035302 (rank : 44)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX41_HUMAN
NC score	0.444921 (rank : 27)	θ value	4.1701e-05 (rank : 22)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX3Y_MOUSE
NC score	0.444762 (rank : 28)	θ value	7.1131e-05 (rank : 25)
Query Neighborhood Hits	177	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX52_HUMAN
NC score	0.444372 (rank : 29)	θ value	0.000461057 (rank : 45)
Query Neighborhood Hits	177	Target Neighborhood Hits	107	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX3X_MOUSE
NC score	0.444098 (rank : 30)	θ value	0.000158464 (rank : 35)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	80
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3X_HUMAN
NC score	0.443991 (rank : 31)	θ value	0.000158464 (rank : 34)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	80
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

IF4A2_HUMAN
NC score	0.443856 (rank : 32)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.443856 (rank : 33)	θ value	0.00020696 (rank : 40)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX3Y_HUMAN
NC score	0.442555 (rank : 34)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	79
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

PL10_MOUSE
NC score	0.442491 (rank : 35)	θ value	0.000158464 (rank : 36)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	80
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX49_MOUSE
NC score	0.437378 (rank : 36)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	177	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_HUMAN
NC score	0.436728 (rank : 37)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	177	Target Neighborhood Hits	223	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX18_MOUSE
NC score	0.436383 (rank : 38)	θ value	9.29e-05 (rank : 30)
Query Neighborhood Hits	177	Target Neighborhood Hits	115	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX18_HUMAN
NC score	0.433332 (rank : 39)	θ value	4.1701e-05 (rank : 21)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX17_HUMAN
NC score	0.433014 (rank : 40)	θ value	0.00298849 (rank : 49)
Query Neighborhood Hits	177	Target Neighborhood Hits	104	Shared Neighborhood Hits	78
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
NC score	0.432998 (rank : 41)	θ value	0.00298849 (rank : 50)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX47_HUMAN
NC score	0.432459 (rank : 42)	θ value	0.00509761 (rank : 56)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
NC score	0.432335 (rank : 43)	θ value	0.00509761 (rank : 57)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX31_HUMAN
NC score	0.429588 (rank : 44)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	79
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX43_HUMAN
NC score	0.429135 (rank : 45)	θ value	0.0193708 (rank : 65)
Query Neighborhood Hits	177	Target Neighborhood Hits	120	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX5_HUMAN
NC score	0.428950 (rank : 46)	θ value	0.00390308 (rank : 53)
Query Neighborhood Hits	177	Target Neighborhood Hits	102	Shared Neighborhood Hits	77
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
NC score	0.428911 (rank : 47)	θ value	0.00390308 (rank : 54)
Query Neighborhood Hits	177	Target Neighborhood Hits	101	Shared Neighborhood Hits	77
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX6_HUMAN
NC score	0.426125 (rank : 48)	θ value	0.000270298 (rank : 42)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.425845 (rank : 49)	θ value	0.000270298 (rank : 43)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX46_HUMAN
NC score	0.425517 (rank : 50)	θ value	0.0252991 (rank : 68)
Query Neighborhood Hits	177	Target Neighborhood Hits	357	Shared Neighborhood Hits	93
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.424162 (rank : 51)	θ value	0.0252991 (rank : 69)
Query Neighborhood Hits	177	Target Neighborhood Hits	358	Shared Neighborhood Hits	91
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX55_MOUSE
NC score	0.424093 (rank : 52)	θ value	0.0193708 (rank : 66)
Query Neighborhood Hits	177	Target Neighborhood Hits	111	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX25_MOUSE
NC score	0.423774 (rank : 53)	θ value	0.00390308 (rank : 52)
Query Neighborhood Hits	177	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
NC score	0.423102 (rank : 54)	θ value	0.00298849 (rank : 51)
Query Neighborhood Hits	177	Target Neighborhood Hits	93	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX39_HUMAN
NC score	0.422161 (rank : 55)	θ value	0.00665767 (rank : 59)
Query Neighborhood Hits	177	Target Neighborhood Hits	94	Shared Neighborhood Hits	76
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
NC score	0.421133 (rank : 56)	θ value	0.00509761 (rank : 55)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX23_HUMAN
NC score	0.421075 (rank : 57)	θ value	0.00869519 (rank : 62)
Query Neighborhood Hits	177	Target Neighborhood Hits	486	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX55_HUMAN
NC score	0.420822 (rank : 58)	θ value	0.0431538 (rank : 77)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX10_MOUSE
NC score	0.420655 (rank : 59)	θ value	0.000602161 (rank : 47)
Query Neighborhood Hits	177	Target Neighborhood Hits	233	Shared Neighborhood Hits	75
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_HUMAN
NC score	0.419907 (rank : 60)	θ value	0.00175202 (rank : 48)
Query Neighborhood Hits	177	Target Neighborhood Hits	210	Shared Neighborhood Hits	78
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX28_MOUSE
NC score	0.416060 (rank : 61)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	177	Target Neighborhood Hits	112	Shared Neighborhood Hits	80
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

UAP56_HUMAN
NC score	0.415178 (rank : 62)	θ value	0.0252991 (rank : 70)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.415135 (rank : 63)	θ value	0.0252991 (rank : 71)
Query Neighborhood Hits	177	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DD19A_MOUSE
NC score	0.414765 (rank : 64)	θ value	0.0431538 (rank : 75)
Query Neighborhood Hits	177	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19A_HUMAN
NC score	0.414556 (rank : 65)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	177	Target Neighborhood Hits	107	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
NC score	0.414203 (rank : 66)	θ value	0.0431538 (rank : 76)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX53_HUMAN
NC score	0.411806 (rank : 67)	θ value	0.163984 (rank : 87)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	76
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX24_MOUSE
NC score	0.406289 (rank : 68)	θ value	0.0563607 (rank : 79)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_HUMAN
NC score	0.404540 (rank : 69)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	177	Target Neighborhood Hits	190	Shared Neighborhood Hits	81
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX20_HUMAN
NC score	0.403728 (rank : 70)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
NC score	0.403114 (rank : 71)	θ value	0.125558 (rank : 85)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX1_MOUSE
NC score	0.402259 (rank : 72)	θ value	0.0148317 (rank : 64)
Query Neighborhood Hits	177	Target Neighborhood Hits	112	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.402175 (rank : 73)	θ value	0.00665767 (rank : 58)
Query Neighborhood Hits	177	Target Neighborhood Hits	110	Shared Neighborhood Hits	73
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX28_HUMAN
NC score	0.387134 (rank : 74)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	177	Target Neighborhood Hits	103	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX54_MOUSE
NC score	0.384397 (rank : 75)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	177	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX54_HUMAN
NC score	0.382449 (rank : 76)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	177	Target Neighborhood Hits	170	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX56_HUMAN
NC score	0.375242 (rank : 77)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	177	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
NC score	0.374835 (rank : 78)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	177	Target Neighborhood Hits	87	Shared Neighborhood Hits	70
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

ERCC4_HUMAN
NC score	0.281698 (rank : 79)	θ value	8.67504e-11 (rank : 8)
Query Neighborhood Hits	177	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q92889, O00140, Q8TD83	Gene names	ERCC4, ERCC11, XPF
Domain Architecture
Description	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA-repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein).

RECQ4_HUMAN
NC score	0.275284 (rank : 80)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	177	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

ERCC4_MOUSE
NC score	0.244332 (rank : 81)	θ value	2.88788e-06 (rank : 14)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QZD4, O54810, Q8R0I3	Gene names	Ercc4
Domain Architecture
Description	DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4).

RECQ4_MOUSE
NC score	0.236610 (rank : 82)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	177	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

HELC1_HUMAN
NC score	0.235411 (rank : 83)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	177	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

RECQ5_HUMAN
NC score	0.228515 (rank : 84)	θ value	0.0563607 (rank : 80)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	79
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_HUMAN
NC score	0.203050 (rank : 85)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	177	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

U520_HUMAN
NC score	0.200565 (rank : 86)	θ value	0.00869519 (rank : 63)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	38
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

WRN_MOUSE
NC score	0.198269 (rank : 87)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	177	Target Neighborhood Hits	295	Shared Neighborhood Hits	75
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

BLM_MOUSE
NC score	0.196929 (rank : 88)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	177	Target Neighborhood Hits	108	Shared Neighborhood Hits	64
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.191827 (rank : 89)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	177	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RECQ1_HUMAN
NC score	0.184901 (rank : 90)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	177	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
NC score	0.182738 (rank : 91)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	177	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

CHD5_HUMAN
NC score	0.075268 (rank : 92)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	177	Target Neighborhood Hits	349	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CC026_HUMAN
NC score	0.070846 (rank : 93)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

ATRX_HUMAN
NC score	0.070402 (rank : 94)	θ value	0.125558 (rank : 84)
Query Neighborhood Hits	177	Target Neighborhood Hits	842	Shared Neighborhood Hits	49
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

AQR_MOUSE
NC score	0.067310 (rank : 95)	θ value	0.365318 (rank : 95)
Query Neighborhood Hits	177	Target Neighborhood Hits	62	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

CHD3_HUMAN
NC score	0.067063 (rank : 96)	θ value	0.00869519 (rank : 61)
Query Neighborhood Hits	177	Target Neighborhood Hits	397	Shared Neighborhood Hits	33
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

AQR_HUMAN
NC score	0.064866 (rank : 97)	θ value	0.365318 (rank : 94)
Query Neighborhood Hits	177	Target Neighborhood Hits	88	Shared Neighborhood Hits	6
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

BTAF1_HUMAN
NC score	0.064693 (rank : 98)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	177	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

ATRX_MOUSE
NC score	0.062880 (rank : 99)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	177	Target Neighborhood Hits	682	Shared Neighborhood Hits	40
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

NRBF2_MOUSE
NC score	0.060648 (rank : 100)	θ value	0.163984 (rank : 89)
Query Neighborhood Hits	177	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCQ3, Q9DCG3	Gene names	Nrbf2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2).

SMAL1_HUMAN
NC score	0.058700 (rank : 101)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	177	Target Neighborhood Hits	174	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

STAG1_HUMAN
NC score	0.053707 (rank : 102)	θ value	0.0330416 (rank : 73)
Query Neighborhood Hits	177	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVM7, O00539	Gene names	STAG1, SA1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

CHD4_MOUSE
NC score	0.053444 (rank : 103)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	177	Target Neighborhood Hits	408	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CHD4_HUMAN
NC score	0.053097 (rank : 104)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	177	Target Neighborhood Hits	365	Shared Neighborhood Hits	41
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

STAG1_MOUSE
NC score	0.052111 (rank : 105)	θ value	0.0736092 (rank : 82)
Query Neighborhood Hits	177	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D3E6, O08982	Gene names	Stag1, Sa1
Domain Architecture
Description	Cohesin subunit SA-1 (Stromal antigen 1) (SCC3 homolog 1).

CLSPN_HUMAN
NC score	0.051176 (rank : 106)	θ value	0.62314 (rank : 97)
Query Neighborhood Hits	177	Target Neighborhood Hits	433	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

RAD54_MOUSE
NC score	0.051169 (rank : 107)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	P70270, Q8BSR5, Q8C2C4, Q8K3D4	Gene names	Rad54l, Rad54
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (mRAD54) (mHR54).

RAD54_HUMAN
NC score	0.050614 (rank : 108)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	177	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	Q92698, Q6IUY3	Gene names	RAD54L, RAD54A
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54-like (EC 3.6.1.-) (RAD54 homolog) (hRAD54) (hHR54).

SMCA1_MOUSE
NC score	0.050357 (rank : 109)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	177	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

MAP1B_HUMAN
NC score	0.047220 (rank : 110)	θ value	0.00665767 (rank : 60)
Query Neighborhood Hits	177	Target Neighborhood Hits	903	Shared Neighborhood Hits	29
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

IWS1_HUMAN
NC score	0.044574 (rank : 111)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	177	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NRBF2_HUMAN
NC score	0.044121 (rank : 112)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	177	Target Neighborhood Hits	122	Shared Neighborhood Hits	8
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

DNL1_HUMAN
NC score	0.043561 (rank : 113)	θ value	0.0961366 (rank : 83)
Query Neighborhood Hits	177	Target Neighborhood Hits	216	Shared Neighborhood Hits	14
SwissProt Accessions	P18858	Gene names	LIG1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

TXND2_MOUSE
NC score	0.043422 (rank : 114)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	177	Target Neighborhood Hits	828	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

PKCB1_HUMAN
NC score	0.042142 (rank : 115)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	177	Target Neighborhood Hits	488	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

ENL_HUMAN
NC score	0.039387 (rank : 116)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	177	Target Neighborhood Hits	305	Shared Neighborhood Hits	21
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

FILA_HUMAN
NC score	0.039312 (rank : 117)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	177	Target Neighborhood Hits	685	Shared Neighborhood Hits	26
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

STAG3_HUMAN
NC score	0.038595 (rank : 118)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	177	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

HIRP3_HUMAN
NC score	0.036796 (rank : 119)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	177	Target Neighborhood Hits	323	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

TCOF_HUMAN
NC score	0.036264 (rank : 120)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	177	Target Neighborhood Hits	543	Shared Neighborhood Hits	25
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

PSTK_HUMAN
NC score	0.033424 (rank : 121)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	177	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IV42, Q6ZSS9	Gene names	PSTK, C10orf89
Domain Architecture	No domain graphic available
Description	L-seryl-tRNA(Ser/Sec) kinase (EC 2.7.1.-) (Phosphoseryl-tRNA(Ser/Sec) kinase).

PHF22_HUMAN
NC score	0.031840 (rank : 122)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	177	Target Neighborhood Hits	121	Shared Neighborhood Hits	9
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

MYCB2_HUMAN
NC score	0.030907 (rank : 123)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	177	Target Neighborhood Hits	390	Shared Neighborhood Hits	14
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

CO3_HUMAN
NC score	0.030492 (rank : 124)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	177	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

ICAL_HUMAN
NC score	0.030375 (rank : 125)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	177	Target Neighborhood Hits	275	Shared Neighborhood Hits	21
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

ZCH11_HUMAN
NC score	0.029972 (rank : 126)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	177	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

CENPC_HUMAN
NC score	0.029310 (rank : 127)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	177	Target Neighborhood Hits	147	Shared Neighborhood Hits	16
SwissProt Accessions	Q03188, Q9P0M5	Gene names	CENPC1, CENPC, ICEN7
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C) (Interphase centromere complex protein 7).

RIOK1_HUMAN
NC score	0.028713 (rank : 128)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	177	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BRS2, Q8NDC8, Q96NV9	Gene names	RIOK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1).

MYCB2_MOUSE
NC score	0.028307 (rank : 129)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	177	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

DPOD3_HUMAN
NC score	0.027961 (rank : 130)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	177	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

SPRL1_MOUSE
NC score	0.026724 (rank : 131)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	177	Target Neighborhood Hits	403	Shared Neighborhood Hits	21
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

CO3_MOUSE
NC score	0.026071 (rank : 132)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	177	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P01027, Q61370	Gene names	C3
Domain Architecture
Description	Complement C3 precursor (HSE-MSF) [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3, isoform Short; Complement C3f fragment].

SPAG1_HUMAN
NC score	0.025384 (rank : 133)	θ value	0.279714 (rank : 93)
Query Neighborhood Hits	177	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q07617, Q7Z5G1	Gene names	SPAG1
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (HSD-3.8).

GNPTA_MOUSE
NC score	0.024246 (rank : 134)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	177	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZN6, Q3U3K6, Q3US34	Gene names	Gnptab, Gnpta, Kiaa1208
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/beta precursor (EC 2.7.8.17) (GlcNAc-1-phosphotransferase alpha/beta subunits) (UDP- N-acetylglucosamine-1-phosphotransferase alpha/beta subunits) (Stealth protein GNPTAB) [Contains: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta].

MSPD2_HUMAN
NC score	0.023472 (rank : 135)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	177	Target Neighborhood Hits	52	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NHP6, Q8N3H2, Q8NA83	Gene names	MOSPD2
Domain Architecture	No domain graphic available
Description	Motile sperm domain-containing protein 2.

NFH_HUMAN
NC score	0.022756 (rank : 136)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	177	Target Neighborhood Hits	1242	Shared Neighborhood Hits	44
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DZIP1_HUMAN
NC score	0.022169 (rank : 137)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	177	Target Neighborhood Hits	675	Shared Neighborhood Hits	17
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

CI082_MOUSE
NC score	0.021412 (rank : 138)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	177	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDY9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf82 homolog.

PDXL2_MOUSE
NC score	0.021221 (rank : 139)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	177	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PHF14_HUMAN
NC score	0.020703 (rank : 140)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	177	Target Neighborhood Hits	447	Shared Neighborhood Hits	20
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

TM131_MOUSE
NC score	0.020022 (rank : 141)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	177	Target Neighborhood Hits	156	Shared Neighborhood Hits	10
SwissProt Accessions	O70472	Gene names	Tmem131, D1Bwg0491e, Rw1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 131 (Protein RW1).

TCEA1_HUMAN
NC score	0.019278 (rank : 142)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	177	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	P23193, Q15563, Q6FG87	Gene names	TCEA1, TFIIS
Domain Architecture
Description	Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o).

CO039_MOUSE
NC score	0.019137 (rank : 143)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	177	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

PHF14_MOUSE
NC score	0.018545 (rank : 144)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	177	Target Neighborhood Hits	342	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

MLL3_HUMAN
NC score	0.017941 (rank : 145)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	177	Target Neighborhood Hits	1644	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

LYST_HUMAN
NC score	0.017935 (rank : 146)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	177	Target Neighborhood Hits	324	Shared Neighborhood Hits	5
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

ABTAP_MOUSE
NC score	0.017906 (rank : 147)	θ value	6.88961 (rank : 151)
Query Neighborhood Hits	177	Target Neighborhood Hits	381	Shared Neighborhood Hits	21
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

NFH_MOUSE
NC score	0.017528 (rank : 148)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	177	Target Neighborhood Hits	2247	Shared Neighborhood Hits	50
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

LN28B_MOUSE
NC score	0.017309 (rank : 149)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	177	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q45KJ6, Q3UZC6, Q3V444	Gene names	Lin28b
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

OTC_MOUSE
NC score	0.016877 (rank : 150)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	177	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

VAPB_HUMAN
NC score	0.016769 (rank : 151)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	177	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

PSIP1_MOUSE
NC score	0.016501 (rank : 152)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	17
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

BCLF1_HUMAN
NC score	0.016480 (rank : 153)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	177	Target Neighborhood Hits	298	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

PCLO_HUMAN
NC score	0.016089 (rank : 154)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	177	Target Neighborhood Hits	2046	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

MY18A_MOUSE
NC score	0.014987 (rank : 155)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	177	Target Neighborhood Hits	1989	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

HXC12_HUMAN
NC score	0.014966 (rank : 156)	θ value	0.47712 (rank : 96)
Query Neighborhood Hits	177	Target Neighborhood Hits	313	Shared Neighborhood Hits	4
SwissProt Accessions	P31275, Q9BXJ6	Gene names	HOXC12, HOX3F
Domain Architecture
Description	Homeobox protein Hox-C12 (Hox-3F).

TIM_HUMAN
NC score	0.014851 (rank : 157)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	177	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNS1, O94802, Q86VM1, Q8IWH3	Gene names	TIMELESS, TIM, TIM1, TIMELESS1
Domain Architecture	No domain graphic available
Description	Timeless homolog (hTIM).

PCLO_MOUSE
NC score	0.014294 (rank : 158)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	177	Target Neighborhood Hits	2275	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

MYH10_MOUSE
NC score	0.013641 (rank : 159)	θ value	0.163984 (rank : 88)
Query Neighborhood Hits	177	Target Neighborhood Hits	1612	Shared Neighborhood Hits	27
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NPM_MOUSE
NC score	0.013620 (rank : 160)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	177	Target Neighborhood Hits	69	Shared Neighborhood Hits	8
SwissProt Accessions	Q61937	Gene names	Npm1
Domain Architecture
Description	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38).

MYH10_HUMAN
NC score	0.013536 (rank : 161)	θ value	0.125558 (rank : 86)
Query Neighborhood Hits	177	Target Neighborhood Hits	1620	Shared Neighborhood Hits	25
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

HXC12_MOUSE
NC score	0.013185 (rank : 162)	θ value	1.06291 (rank : 102)
Query Neighborhood Hits	177	Target Neighborhood Hits	316	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

MYH9_HUMAN
NC score	0.012736 (rank : 163)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	177	Target Neighborhood Hits	1762	Shared Neighborhood Hits	39
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NU153_HUMAN
NC score	0.012665 (rank : 164)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	4
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

K1718_HUMAN
NC score	0.012302 (rank : 165)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	177	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q6ZMT4, Q6MZL8, Q9C0E5	Gene names	KIAA1718
Domain Architecture	No domain graphic available
Description	Protein KIAA1718.

SF3B3_HUMAN
NC score	0.012300 (rank : 166)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	177	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q15393, Q9UJ29	Gene names	SF3B3, KIAA0017, SAP130
Domain Architecture
Description	Splicing factor 3B subunit 3 (Spliceosome-associated protein 130) (SAP 130) (SF3b130) (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (STAF130).

FRS2_HUMAN
NC score	0.011774 (rank : 167)	θ value	5.27518 (rank : 142)
Query Neighborhood Hits	177	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WU20, O43558, Q7LDQ6	Gene names	FRS2
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (Suc1-associated neurotrophic factor target 1) (SNT-1) (FGFR signaling adaptor SNT).

UBP53_MOUSE
NC score	0.011504 (rank : 168)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	177	Target Neighborhood Hits	188	Shared Neighborhood Hits	11
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

THAP7_HUMAN
NC score	0.011158 (rank : 169)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	177	Target Neighborhood Hits	59	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BT49	Gene names	THAP7
Domain Architecture
Description	THAP domain-containing protein 7.

CTND2_MOUSE
NC score	0.010817 (rank : 170)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	177	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

NMDE1_MOUSE
NC score	0.010450 (rank : 171)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	177	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	P35436	Gene names	Grin2a
Domain Architecture	No domain graphic available
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A).

CTND1_HUMAN
NC score	0.010180 (rank : 172)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	177	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

NMDE1_HUMAN
NC score	0.010079 (rank : 173)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	177	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q12879, O00669	Gene names	GRIN2A
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 1 precursor (N-methyl D- aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

JHD1B_MOUSE
NC score	0.010012 (rank : 174)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	177	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

INADL_MOUSE
NC score	0.009568 (rank : 175)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	177	Target Neighborhood Hits	290	Shared Neighborhood Hits	7
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

FLIP1_MOUSE
NC score	0.009490 (rank : 176)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	177	Target Neighborhood Hits	1176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CTND2_HUMAN
NC score	0.009489 (rank : 177)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	177	Target Neighborhood Hits	333	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

SFR12_HUMAN
NC score	0.008571 (rank : 178)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	177	Target Neighborhood Hits	553	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

CLMN_HUMAN
NC score	0.008554 (rank : 179)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	177	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

GCC2_MOUSE
NC score	0.007013 (rank : 180)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	177	Target Neighborhood Hits	1619	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

P55G_HUMAN
NC score	0.006535 (rank : 181)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	177	Target Neighborhood Hits	451	Shared Neighborhood Hits	9
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CSPG3_HUMAN
NC score	0.002529 (rank : 182)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	177	Target Neighborhood Hits	676	Shared Neighborhood Hits	8
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

LRP5_HUMAN
NC score	0.001873 (rank : 183)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	177	Target Neighborhood Hits	224	Shared Neighborhood Hits	2
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

MYPC2_MOUSE
NC score	0.001744 (rank : 184)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	177	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

ARD1_MOUSE
NC score	0.001703 (rank : 185)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	177	Target Neighborhood Hits	573	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

ARD1_HUMAN
NC score	0.001295 (rank : 186)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	177	Target Neighborhood Hits	621	Shared Neighborhood Hits	4
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

PAX3_MOUSE
NC score	0.001086 (rank : 187)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	177	Target Neighborhood Hits	478	Shared Neighborhood Hits	5
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

ZFP91_HUMAN
NC score	-0.000821 (rank : 188)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	177	Target Neighborhood Hits	769	Shared Neighborhood Hits	9
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

ZFP91_MOUSE
NC score	-0.000865 (rank : 189)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	177	Target Neighborhood Hits	742	Shared Neighborhood Hits	6
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

ACM5_HUMAN
NC score	-0.003157 (rank : 190)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	177	Target Neighborhood Hits	878	Shared Neighborhood Hits	2
SwissProt Accessions	P08912, Q96RG7	Gene names	CHRM5
Domain Architecture
Description	Muscarinic acetylcholine receptor M5.

M3K5_MOUSE
NC score	-0.004368 (rank : 191)	θ value	5.27518 (rank : 143)
Query Neighborhood Hits	177	Target Neighborhood Hits	867	Shared Neighborhood Hits	5
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

NUAK1_MOUSE
NC score	-0.005187 (rank : 192)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	177	Target Neighborhood Hits	881	Shared Neighborhood Hits	6
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).