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Network neighborhood for query Sequence : DDX18_HUMAN

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DDX18_HUMAN
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDX18_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
θ value	0 (rank : 2)	NC score	0.996415 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX10_HUMAN
θ value	1.34698e-104 (rank : 3)	NC score	0.976488 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	85
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	1.75921e-104 (rank : 4)	NC score	0.976655 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX31_HUMAN
θ value	2.24094e-75 (rank : 5)	NC score	0.971422 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX55_HUMAN
θ value	2.09745e-73 (rank : 6)	NC score	0.975794 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
θ value	7.97034e-73 (rank : 7)	NC score	0.977177 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	77
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX47_HUMAN
θ value	7.24236e-58 (rank : 8)	NC score	0.968589 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	6.13105e-57 (rank : 9)	NC score	0.968850 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX27_MOUSE
θ value	7.75577e-52 (rank : 10)	NC score	0.960382 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	83
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_HUMAN
θ value	6.56568e-51 (rank : 11)	NC score	0.958064 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	197	Shared Neighborhood Hits	83
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX49_HUMAN
θ value	5.55816e-50 (rank : 12)	NC score	0.959622 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_MOUSE
θ value	9.48078e-50 (rank : 13)	NC score	0.962981 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX17_HUMAN
θ value	5.38352e-45 (rank : 14)	NC score	0.946284 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	79
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	5.38352e-45 (rank : 15)	NC score	0.946378 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	78
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX41_MOUSE
θ value	1.01529e-43 (rank : 16)	NC score	0.952747 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX41_HUMAN
θ value	1.32601e-43 (rank : 17)	NC score	0.953188 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX54_MOUSE
θ value	1.73182e-43 (rank : 18)	NC score	0.955245 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX50_MOUSE
θ value	3.85808e-43 (rank : 19)	NC score	0.941741 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_HUMAN
θ value	6.58091e-43 (rank : 20)	NC score	0.941254 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX43_HUMAN
θ value	8.59492e-43 (rank : 21)	NC score	0.948184 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX4_HUMAN
θ value	8.59492e-43 (rank : 22)	NC score	0.947635 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	123	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX4_MOUSE
θ value	1.12253e-42 (rank : 23)	NC score	0.948747 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX54_HUMAN
θ value	1.12253e-42 (rank : 24)	NC score	0.952174 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX5_HUMAN
θ value	3.26607e-42 (rank : 25)	NC score	0.942339 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	7.27602e-42 (rank : 26)	NC score	0.942216 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX21_HUMAN
θ value	1.2411e-41 (rank : 27)	NC score	0.931115 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX3X_HUMAN
θ value	2.11701e-41 (rank : 28)	NC score	0.934462 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	78
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

PL10_MOUSE
θ value	2.76489e-41 (rank : 29)	NC score	0.934869 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	78
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX46_HUMAN
θ value	1.3722e-40 (rank : 30)	NC score	0.930456 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	357	Shared Neighborhood Hits	93
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	1.3722e-40 (rank : 31)	NC score	0.928006 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	358	Shared Neighborhood Hits	92
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX3X_MOUSE
θ value	1.79215e-40 (rank : 32)	NC score	0.933541 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	117	Shared Neighborhood Hits	78
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX52_HUMAN
θ value	3.37985e-39 (rank : 33)	NC score	0.949148 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX6_HUMAN
θ value	3.37985e-39 (rank : 34)	NC score	0.950786 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	3.37985e-39 (rank : 35)	NC score	0.950644 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	78
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX48_HUMAN
θ value	4.41421e-39 (rank : 36)	NC score	0.939412 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX21_MOUSE
θ value	5.76516e-39 (rank : 37)	NC score	0.923916 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	350	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX48_MOUSE
θ value	5.76516e-39 (rank : 38)	NC score	0.939206 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX3Y_MOUSE
θ value	7.52953e-39 (rank : 39)	NC score	0.935384 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX3Y_HUMAN
θ value	9.83387e-39 (rank : 40)	NC score	0.932242 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

IF4A1_HUMAN
θ value	1.28434e-38 (rank : 41)	NC score	0.937235 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	78
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	1.28434e-38 (rank : 42)	NC score	0.937235 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	78
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX52_MOUSE
θ value	2.19075e-38 (rank : 43)	NC score	0.949841 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX53_HUMAN
θ value	2.19075e-38 (rank : 44)	NC score	0.942369 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	74
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX23_HUMAN
θ value	3.73686e-38 (rank : 45)	NC score	0.922847 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX39_HUMAN
θ value	2.42216e-37 (rank : 46)	NC score	0.940927 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

IF4A2_HUMAN
θ value	3.16345e-37 (rank : 47)	NC score	0.936384 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	3.16345e-37 (rank : 48)	NC score	0.936384 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX39_MOUSE
θ value	7.79185e-36 (rank : 49)	NC score	0.939874 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

UAP56_HUMAN
θ value	8.61488e-35 (rank : 50)	NC score	0.939162 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	8.61488e-35 (rank : 51)	NC score	0.939089 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX51_MOUSE
θ value	1.12514e-34 (rank : 52)	NC score	0.938643 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX24_HUMAN
θ value	1.46948e-34 (rank : 53)	NC score	0.933609 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	190	Shared Neighborhood Hits	82
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX56_HUMAN
θ value	1.6247e-33 (rank : 54)	NC score	0.949704 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	77	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX24_MOUSE
θ value	2.77131e-33 (rank : 55)	NC score	0.936024 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	147	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX51_HUMAN
θ value	2.34606e-32 (rank : 56)	NC score	0.924453 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX56_MOUSE
θ value	3.3877e-31 (rank : 57)	NC score	0.947701 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DD19B_HUMAN
θ value	1.73987e-27 (rank : 58)	NC score	0.911773 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_MOUSE
θ value	3.28125e-26 (rank : 59)	NC score	0.911285 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX28_MOUSE
θ value	7.30988e-26 (rank : 60)	NC score	0.940677 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DD19A_HUMAN
θ value	1.24688e-25 (rank : 61)	NC score	0.911997 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DDX20_HUMAN
θ value	8.08199e-25 (rank : 62)	NC score	0.924143 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
θ value	2.35151e-24 (rank : 63)	NC score	0.921108 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX25_MOUSE
θ value	3.07116e-24 (rank : 64)	NC score	0.911589 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
θ value	4.01107e-24 (rank : 65)	NC score	0.912796 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX28_HUMAN
θ value	7.82807e-20 (rank : 66)	NC score	0.936583 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX1_HUMAN
θ value	2.79066e-09 (rank : 67)	NC score	0.854820 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	78
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX1_MOUSE
θ value	2.79066e-09 (rank : 68)	NC score	0.855639 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

FANCM_HUMAN
θ value	3.19293e-05 (rank : 69)	NC score	0.436658 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	4.1701e-05 (rank : 70)	NC score	0.433332 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

BLM_HUMAN
θ value	0.000158464 (rank : 71)	NC score	0.452982 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	0.000158464 (rank : 72)	NC score	0.465261 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

WRN_HUMAN
θ value	0.00175202 (rank : 73)	NC score	0.430809 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	76
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ4_HUMAN
θ value	0.00869519 (rank : 74)	NC score	0.512171 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

NIPBL_HUMAN
θ value	0.0193708 (rank : 75)	NC score	0.044232 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	1311	Shared Neighborhood Hits	40
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

ESCO1_HUMAN
θ value	0.0431538 (rank : 76)	NC score	0.026396 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

DICER_HUMAN
θ value	0.0961366 (rank : 77)	NC score	0.385683 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

RECQ4_MOUSE
θ value	0.0961366 (rank : 78)	NC score	0.490136 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

DPOD3_HUMAN
θ value	0.163984 (rank : 79)	NC score	0.027465 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

DICER_MOUSE
θ value	0.21417 (rank : 80)	NC score	0.383325 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	76
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

GOGB1_HUMAN
θ value	0.47712 (rank : 81)	NC score	0.008334 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	2297	Shared Neighborhood Hits	37
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ZF106_MOUSE
θ value	0.62314 (rank : 82)	NC score	0.007436 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	472	Shared Neighborhood Hits	10
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

AGGF1_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.013069 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

MPP8_HUMAN
θ value	0.813845 (rank : 84)	NC score	0.029312 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	31
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

TXND2_MOUSE
θ value	0.813845 (rank : 85)	NC score	0.040199 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

DMP1_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.026882 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	491	Shared Neighborhood Hits	31
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

LRCH3_HUMAN
θ value	1.38821 (rank : 87)	NC score	0.005588 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q96II8, Q96FP9, Q9NT52	Gene names	LRCH3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

MATR3_MOUSE
θ value	1.38821 (rank : 88)	NC score	0.023385 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	321	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

REST_MOUSE
θ value	1.38821 (rank : 89)	NC score	-0.000350 (rank : 133)
Query Neighborhood Hits	124	Target Neighborhood Hits	1506	Shared Neighborhood Hits	22
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SKIV2_HUMAN
θ value	1.38821 (rank : 90)	NC score	0.049685 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

ZBT38_HUMAN
θ value	1.38821 (rank : 91)	NC score	-0.005870 (rank : 136)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

MATR3_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.021558 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	325	Shared Neighborhood Hits	17
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

MLL3_HUMAN
θ value	1.81305 (rank : 93)	NC score	0.000870 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	1644	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

AFF4_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.021581 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	611	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

CT026_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.013639 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHU2, Q5TE18, Q8N5R9, Q96M59, Q9BQL2, Q9H127, Q9H128, Q9NQH4, Q9UFV8, Q9Y4V7	Gene names	C20orf26
Domain Architecture
Description	Uncharacterized protein C20orf26.

NKTR_HUMAN
θ value	2.36792 (rank : 96)	NC score	0.023817 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	658	Shared Neighborhood Hits	34
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

THUM1_HUMAN
θ value	2.36792 (rank : 97)	NC score	0.012498 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NXG2, Q9BWC3	Gene names	THUMPD1
Domain Architecture
Description	THUMP domain-containing protein 1.

WNK3_HUMAN
θ value	2.36792 (rank : 98)	NC score	-0.005882 (rank : 137)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

CEBPZ_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.008785 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	Q03701, Q8NE75	Gene names	CEBPZ, CBF2
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

CYLC1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.019060 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	408	Shared Neighborhood Hits	24
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

IWS1_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.026444 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	1241	Shared Neighborhood Hits	42
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K0179_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.009140 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

CBP_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.000208 (rank : 132)
Query Neighborhood Hits	124	Target Neighborhood Hits	1051	Shared Neighborhood Hits	15
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

JIP4_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.004961 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	585	Shared Neighborhood Hits	10
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

LUZP1_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.000765 (rank : 131)
Query Neighborhood Hits	124	Target Neighborhood Hits	739	Shared Neighborhood Hits	12
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

NPBL_MOUSE
θ value	4.03905 (rank : 106)	NC score	0.038388 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	1041	Shared Neighborhood Hits	38
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

TCAL5_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.018720 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	27
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

ZEP2_MOUSE
θ value	4.03905 (rank : 108)	NC score	-0.004579 (rank : 135)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	10
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

DDX58_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.184430 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	99	Shared Neighborhood Hits	55
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

NCOR2_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.005034 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	790	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

TS101_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.008310 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	359	Shared Neighborhood Hits	8
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

TS101_MOUSE
θ value	5.27518 (rank : 112)	NC score	0.009533 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	312	Shared Neighborhood Hits	9
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

CATA_HUMAN
θ value	6.88961 (rank : 113)	NC score	0.006037 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P04040, Q4VXX5, Q9BWT9	Gene names	CAT
Domain Architecture
Description	Catalase (EC 1.11.1.6).

PSIP1_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.010320 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

SPEG_MOUSE
θ value	6.88961 (rank : 115)	NC score	-0.006063 (rank : 138)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	22
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TGON2_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.011116 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	277	Shared Neighborhood Hits	14
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

ANK3_HUMAN
θ value	8.99809 (rank : 117)	NC score	-0.001882 (rank : 134)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	20
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

AP3B2_MOUSE
θ value	8.99809 (rank : 118)	NC score	0.004924 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

EAPP_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.005802 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q56P03, Q9BVF4, Q9NWV5, Q9NZ86	Gene names	EAPP, C14orf11
Domain Architecture	No domain graphic available
Description	E2F-associated phosphoprotein (EAPP).

IWS1_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.023388 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	1258	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LRCH3_MOUSE
θ value	8.99809 (rank : 121)	NC score	0.002575 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

PSIP1_HUMAN
θ value	8.99809 (rank : 122)	NC score	0.010078 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

TPX2_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.005277 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

YTDC1_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.012500 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	458	Shared Neighborhood Hits	27
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

CC026_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.148853 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	39	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

CC026_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.117116 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

DDX58_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.149264 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	51
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

HELC1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.089994 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

IFIH1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.288657 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

IFIH1_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.276707 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.281018 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	66
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

LGP2_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.295562 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

RECQ1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.387315 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.387348 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ5_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.418319 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	75
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SMAL1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.069270 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

U520_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.133906 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

WRN_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.385639 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	295	Shared Neighborhood Hits	80
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

Hits sorted by NC score

DDX18_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
NC score	0.996415 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX55_MOUSE
NC score	0.977177 (rank : 3)	θ value	7.97034e-73 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	77
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX10_MOUSE
NC score	0.976655 (rank : 4)	θ value	1.75921e-104 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_HUMAN
NC score	0.976488 (rank : 5)	θ value	1.34698e-104 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	85
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX55_HUMAN
NC score	0.975794 (rank : 6)	θ value	2.09745e-73 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX31_HUMAN
NC score	0.971422 (rank : 7)	θ value	2.24094e-75 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX47_MOUSE
NC score	0.968850 (rank : 8)	θ value	6.13105e-57 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_HUMAN
NC score	0.968589 (rank : 9)	θ value	7.24236e-58 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX49_MOUSE
NC score	0.962981 (rank : 10)	θ value	9.48078e-50 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	119	Shared Neighborhood Hits	79
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_MOUSE
NC score	0.960382 (rank : 11)	θ value	7.75577e-52 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	83
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX49_HUMAN
NC score	0.959622 (rank : 12)	θ value	5.55816e-50 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_HUMAN
NC score	0.958064 (rank : 13)	θ value	6.56568e-51 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	197	Shared Neighborhood Hits	83
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX54_MOUSE
NC score	0.955245 (rank : 14)	θ value	1.73182e-43 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX41_HUMAN
NC score	0.953188 (rank : 15)	θ value	1.32601e-43 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
NC score	0.952747 (rank : 16)	θ value	1.01529e-43 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX54_HUMAN
NC score	0.952174 (rank : 17)	θ value	1.12253e-42 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX6_HUMAN
NC score	0.950786 (rank : 18)	θ value	3.37985e-39 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	78
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.950644 (rank : 19)	θ value	3.37985e-39 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	78
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX52_MOUSE
NC score	0.949841 (rank : 20)	θ value	2.19075e-38 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX56_HUMAN
NC score	0.949704 (rank : 21)	θ value	1.6247e-33 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	77	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX52_HUMAN
NC score	0.949148 (rank : 22)	θ value	3.37985e-39 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX4_MOUSE
NC score	0.948747 (rank : 23)	θ value	1.12253e-42 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX43_HUMAN
NC score	0.948184 (rank : 24)	θ value	8.59492e-43 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX56_MOUSE
NC score	0.947701 (rank : 25)	θ value	3.3877e-31 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX4_HUMAN
NC score	0.947635 (rank : 26)	θ value	8.59492e-43 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	123	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX17_MOUSE
NC score	0.946378 (rank : 27)	θ value	5.38352e-45 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	78
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.946284 (rank : 28)	θ value	5.38352e-45 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	79
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX53_HUMAN
NC score	0.942369 (rank : 29)	θ value	2.19075e-38 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	74
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX5_HUMAN
NC score	0.942339 (rank : 30)	θ value	3.26607e-42 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
NC score	0.942216 (rank : 31)	θ value	7.27602e-42 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	78
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX50_MOUSE
NC score	0.941741 (rank : 32)	θ value	3.85808e-43 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_HUMAN
NC score	0.941254 (rank : 33)	θ value	6.58091e-43 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	84
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX39_HUMAN
NC score	0.940927 (rank : 34)	θ value	2.42216e-37 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	78
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX28_MOUSE
NC score	0.940677 (rank : 35)	θ value	7.30988e-26 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX39_MOUSE
NC score	0.939874 (rank : 36)	θ value	7.79185e-36 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX48_HUMAN
NC score	0.939412 (rank : 37)	θ value	4.41421e-39 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.939206 (rank : 38)	θ value	5.76516e-39 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

UAP56_HUMAN
NC score	0.939162 (rank : 39)	θ value	8.61488e-35 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.939089 (rank : 40)	θ value	8.61488e-35 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX51_MOUSE
NC score	0.938643 (rank : 41)	θ value	1.12514e-34 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

IF4A1_HUMAN
NC score	0.937235 (rank : 42)	θ value	1.28434e-38 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	78
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.937235 (rank : 43)	θ value	1.28434e-38 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	78
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX28_HUMAN
NC score	0.936583 (rank : 44)	θ value	7.82807e-20 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

IF4A2_HUMAN
NC score	0.936384 (rank : 45)	θ value	3.16345e-37 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.936384 (rank : 46)	θ value	3.16345e-37 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	78
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX24_MOUSE
NC score	0.936024 (rank : 47)	θ value	2.77131e-33 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	147	Shared Neighborhood Hits	80
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX3Y_MOUSE
NC score	0.935384 (rank : 48)	θ value	7.52953e-39 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	79
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

PL10_MOUSE
NC score	0.934869 (rank : 49)	θ value	2.76489e-41 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	78
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_HUMAN
NC score	0.934462 (rank : 50)	θ value	2.11701e-41 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	78
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX24_HUMAN
NC score	0.933609 (rank : 51)	θ value	1.46948e-34 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	190	Shared Neighborhood Hits	82
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX3X_MOUSE
NC score	0.933541 (rank : 52)	θ value	1.79215e-40 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	117	Shared Neighborhood Hits	78
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
NC score	0.932242 (rank : 53)	θ value	9.83387e-39 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX21_HUMAN
NC score	0.931115 (rank : 54)	θ value	1.2411e-41 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX46_HUMAN
NC score	0.930456 (rank : 55)	θ value	1.3722e-40 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	357	Shared Neighborhood Hits	93
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.928006 (rank : 56)	θ value	1.3722e-40 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	358	Shared Neighborhood Hits	92
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX51_HUMAN
NC score	0.924453 (rank : 57)	θ value	2.34606e-32 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX20_HUMAN
NC score	0.924143 (rank : 58)	θ value	8.08199e-25 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX21_MOUSE
NC score	0.923916 (rank : 59)	θ value	5.76516e-39 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	350	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX23_HUMAN
NC score	0.922847 (rank : 60)	θ value	3.73686e-38 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX20_MOUSE
NC score	0.921108 (rank : 61)	θ value	2.35151e-24 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX25_HUMAN
NC score	0.912796 (rank : 62)	θ value	4.01107e-24 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DD19A_HUMAN
NC score	0.911997 (rank : 63)	θ value	1.24688e-25 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
NC score	0.911773 (rank : 64)	θ value	1.73987e-27 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX25_MOUSE
NC score	0.911589 (rank : 65)	θ value	3.07116e-24 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DD19A_MOUSE
NC score	0.911285 (rank : 66)	θ value	3.28125e-26 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	77
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX1_MOUSE
NC score	0.855639 (rank : 67)	θ value	2.79066e-09 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.854820 (rank : 68)	θ value	2.79066e-09 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	78
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

RECQ4_HUMAN
NC score	0.512171 (rank : 69)	θ value	0.00869519 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	80
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.490136 (rank : 70)	θ value	0.0961366 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	79
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

BLM_MOUSE
NC score	0.465261 (rank : 71)	θ value	0.000158464 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.452982 (rank : 72)	θ value	0.000158464 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

FANCM_HUMAN
NC score	0.436658 (rank : 73)	θ value	3.19293e-05 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	76
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.433332 (rank : 74)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

WRN_HUMAN
NC score	0.430809 (rank : 75)	θ value	0.00175202 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	76
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ5_HUMAN
NC score	0.418319 (rank : 76)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	75
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RECQ1_MOUSE
NC score	0.387348 (rank : 77)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	124	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_HUMAN
NC score	0.387315 (rank : 78)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DICER_HUMAN
NC score	0.385683 (rank : 79)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

WRN_MOUSE
NC score	0.385639 (rank : 80)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	124	Target Neighborhood Hits	295	Shared Neighborhood Hits	80
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

DICER_MOUSE
NC score	0.383325 (rank : 81)	θ value	0.21417 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	76
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

LGP2_MOUSE
NC score	0.295562 (rank : 82)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	124	Target Neighborhood Hits	86	Shared Neighborhood Hits	64
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_HUMAN
NC score	0.288657 (rank : 83)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_HUMAN
NC score	0.281018 (rank : 84)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	66
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_MOUSE
NC score	0.276707 (rank : 85)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DDX58_MOUSE
NC score	0.184430 (rank : 86)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	99	Shared Neighborhood Hits	55
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
NC score	0.149264 (rank : 87)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	51
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_HUMAN
NC score	0.148853 (rank : 88)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	39	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

U520_HUMAN
NC score	0.133906 (rank : 89)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

CC026_MOUSE
NC score	0.117116 (rank : 90)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

HELC1_HUMAN
NC score	0.089994 (rank : 91)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
NC score	0.069270 (rank : 92)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SKIV2_HUMAN
NC score	0.049685 (rank : 93)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

NIPBL_HUMAN
NC score	0.044232 (rank : 94)	θ value	0.0193708 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	1311	Shared Neighborhood Hits	40
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

TXND2_MOUSE
NC score	0.040199 (rank : 95)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	828	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

NPBL_MOUSE
NC score	0.038388 (rank : 96)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	1041	Shared Neighborhood Hits	38
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

MPP8_HUMAN
NC score	0.029312 (rank : 97)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	31
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

DPOD3_HUMAN
NC score	0.027465 (rank : 98)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

DMP1_HUMAN
NC score	0.026882 (rank : 99)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	491	Shared Neighborhood Hits	31
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

IWS1_HUMAN
NC score	0.026444 (rank : 100)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	1241	Shared Neighborhood Hits	42
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ESCO1_HUMAN
NC score	0.026396 (rank : 101)	θ value	0.0431538 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	361	Shared Neighborhood Hits	22
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

NKTR_HUMAN
NC score	0.023817 (rank : 102)	θ value	2.36792 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	658	Shared Neighborhood Hits	34
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

IWS1_MOUSE
NC score	0.023388 (rank : 103)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	1258	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MATR3_MOUSE
NC score	0.023385 (rank : 104)	θ value	1.38821 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	321	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

AFF4_HUMAN
NC score	0.021581 (rank : 105)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	611	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

MATR3_HUMAN
NC score	0.021558 (rank : 106)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	325	Shared Neighborhood Hits	17
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

CYLC1_HUMAN
NC score	0.019060 (rank : 107)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	408	Shared Neighborhood Hits	24
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

TCAL5_HUMAN
NC score	0.018720 (rank : 108)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	806	Shared Neighborhood Hits	27
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

CT026_HUMAN
NC score	0.013639 (rank : 109)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NHU2, Q5TE18, Q8N5R9, Q96M59, Q9BQL2, Q9H127, Q9H128, Q9NQH4, Q9UFV8, Q9Y4V7	Gene names	C20orf26
Domain Architecture
Description	Uncharacterized protein C20orf26.

AGGF1_HUMAN
NC score	0.013069 (rank : 110)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	271	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

YTDC1_HUMAN
NC score	0.012500 (rank : 111)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	458	Shared Neighborhood Hits	27
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

THUM1_HUMAN
NC score	0.012498 (rank : 112)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NXG2, Q9BWC3	Gene names	THUMPD1
Domain Architecture
Description	THUMP domain-containing protein 1.

TGON2_MOUSE
NC score	0.011116 (rank : 113)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	277	Shared Neighborhood Hits	14
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

PSIP1_MOUSE
NC score	0.010320 (rank : 114)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	Q99JF8, Q3TEJ7, Q3TTD7, Q3UTA1, Q80WQ7, Q99JF7, Q99LR4, Q9CT03	Gene names	Psip1, Ledgf
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (mLEDGF).

PSIP1_HUMAN
NC score	0.010078 (rank : 115)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	341	Shared Neighborhood Hits	20
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

TS101_MOUSE
NC score	0.009533 (rank : 116)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	312	Shared Neighborhood Hits	9
SwissProt Accessions	Q61187	Gene names	Tsg101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

K0179_HUMAN
NC score	0.009140 (rank : 117)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	81	Shared Neighborhood Hits	5
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

CEBPZ_HUMAN
NC score	0.008785 (rank : 118)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	Q03701, Q8NE75	Gene names	CEBPZ, CBF2
Domain Architecture
Description	CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding factor) (CBF).

GOGB1_HUMAN
NC score	0.008334 (rank : 119)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	2297	Shared Neighborhood Hits	37
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

TS101_HUMAN
NC score	0.008310 (rank : 120)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	359	Shared Neighborhood Hits	8
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

ZF106_MOUSE
NC score	0.007436 (rank : 121)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	472	Shared Neighborhood Hits	10
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

CATA_HUMAN
NC score	0.006037 (rank : 122)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P04040, Q4VXX5, Q9BWT9	Gene names	CAT
Domain Architecture
Description	Catalase (EC 1.11.1.6).

EAPP_HUMAN
NC score	0.005802 (rank : 123)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q56P03, Q9BVF4, Q9NWV5, Q9NZ86	Gene names	EAPP, C14orf11
Domain Architecture	No domain graphic available
Description	E2F-associated phosphoprotein (EAPP).

LRCH3_HUMAN
NC score	0.005588 (rank : 124)	θ value	1.38821 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q96II8, Q96FP9, Q9NT52	Gene names	LRCH3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

TPX2_HUMAN
NC score	0.005277 (rank : 125)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	150	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

NCOR2_MOUSE
NC score	0.005034 (rank : 126)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	790	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

JIP4_HUMAN
NC score	0.004961 (rank : 127)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	585	Shared Neighborhood Hits	10
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

AP3B2_MOUSE
NC score	0.004924 (rank : 128)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

LRCH3_MOUSE
NC score	0.002575 (rank : 129)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	257	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

MLL3_HUMAN
NC score	0.000870 (rank : 130)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	1644	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

LUZP1_HUMAN
NC score	0.000765 (rank : 131)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	739	Shared Neighborhood Hits	12
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

CBP_MOUSE
NC score	0.000208 (rank : 132)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	1051	Shared Neighborhood Hits	15
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

REST_MOUSE
NC score	-0.000350 (rank : 133)	θ value	1.38821 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	1506	Shared Neighborhood Hits	22
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

ANK3_HUMAN
NC score	-0.001882 (rank : 134)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	853	Shared Neighborhood Hits	20
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ZEP2_MOUSE
NC score	-0.004579 (rank : 135)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	964	Shared Neighborhood Hits	10
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZBT38_HUMAN
NC score	-0.005870 (rank : 136)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	885	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

WNK3_HUMAN
NC score	-0.005882 (rank : 137)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	948	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

SPEG_MOUSE
NC score	-0.006063 (rank : 138)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	22
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).