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Network neighborhood for query Sequence : DDX50_HUMAN

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DDX50_HUMAN
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDX21_HUMAN
θ value	0 (rank : 1)	NC score	0.982858 (rank : 3)
Query Neighborhood Hits	132	Target Neighborhood Hits	308	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX21_MOUSE
θ value	0 (rank : 2)	NC score	0.975774 (rank : 4)
Query Neighborhood Hits	132	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX50_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
θ value	0 (rank : 4)	NC score	0.998085 (rank : 2)
Query Neighborhood Hits	132	Target Neighborhood Hits	137	Shared Neighborhood Hits	112
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX17_HUMAN
θ value	7.75577e-52 (rank : 5)	NC score	0.955285 (rank : 6)
Query Neighborhood Hits	132	Target Neighborhood Hits	104	Shared Neighborhood Hits	88
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	7.75577e-52 (rank : 6)	NC score	0.955418 (rank : 5)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	88
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX4_MOUSE
θ value	2.49495e-50 (rank : 7)	NC score	0.954974 (rank : 7)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX4_HUMAN
θ value	7.25919e-50 (rank : 8)	NC score	0.953783 (rank : 8)
Query Neighborhood Hits	132	Target Neighborhood Hits	123	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX5_HUMAN
θ value	1.788e-48 (rank : 9)	NC score	0.952157 (rank : 10)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	8.87376e-48 (rank : 10)	NC score	0.951997 (rank : 11)
Query Neighborhood Hits	132	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX3X_HUMAN
θ value	1.28137e-46 (rank : 11)	NC score	0.943509 (rank : 23)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	91
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX53_HUMAN
θ value	1.28137e-46 (rank : 12)	NC score	0.949878 (rank : 16)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	88
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX46_HUMAN
θ value	2.18568e-46 (rank : 13)	NC score	0.935501 (rank : 46)
Query Neighborhood Hits	132	Target Neighborhood Hits	357	Shared Neighborhood Hits	100
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	2.18568e-46 (rank : 14)	NC score	0.933332 (rank : 47)
Query Neighborhood Hits	132	Target Neighborhood Hits	358	Shared Neighborhood Hits	101
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

PL10_MOUSE
θ value	2.85459e-46 (rank : 15)	NC score	0.943468 (rank : 24)
Query Neighborhood Hits	132	Target Neighborhood Hits	120	Shared Neighborhood Hits	92
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_MOUSE
θ value	3.72821e-46 (rank : 16)	NC score	0.943331 (rank : 25)
Query Neighborhood Hits	132	Target Neighborhood Hits	117	Shared Neighborhood Hits	90
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_MOUSE
θ value	3.72821e-46 (rank : 17)	NC score	0.943767 (rank : 22)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	93
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX3Y_HUMAN
θ value	1.08474e-45 (rank : 18)	NC score	0.942240 (rank : 29)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	89
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX23_HUMAN
θ value	9.18288e-45 (rank : 19)	NC score	0.924949 (rank : 53)
Query Neighborhood Hits	132	Target Neighborhood Hits	486	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX10_HUMAN
θ value	1.73182e-43 (rank : 20)	NC score	0.937532 (rank : 42)
Query Neighborhood Hits	132	Target Neighborhood Hits	210	Shared Neighborhood Hits	90
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX48_HUMAN
θ value	5.03882e-43 (rank : 21)	NC score	0.946285 (rank : 19)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX18_HUMAN
θ value	6.58091e-43 (rank : 22)	NC score	0.941254 (rank : 33)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX48_MOUSE
θ value	6.58091e-43 (rank : 23)	NC score	0.946080 (rank : 20)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX18_MOUSE
θ value	8.59492e-43 (rank : 24)	NC score	0.941038 (rank : 34)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX43_HUMAN
θ value	1.12253e-42 (rank : 25)	NC score	0.953182 (rank : 9)
Query Neighborhood Hits	132	Target Neighborhood Hits	120	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX10_MOUSE
θ value	1.91475e-42 (rank : 26)	NC score	0.937126 (rank : 44)
Query Neighborhood Hits	132	Target Neighborhood Hits	233	Shared Neighborhood Hits	93
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX41_MOUSE
θ value	4.71619e-41 (rank : 27)	NC score	0.950853 (rank : 13)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX6_HUMAN
θ value	4.71619e-41 (rank : 28)	NC score	0.948678 (rank : 17)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	4.71619e-41 (rank : 29)	NC score	0.948440 (rank : 18)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

IF4A1_HUMAN
θ value	4.71619e-41 (rank : 30)	NC score	0.941428 (rank : 31)
Query Neighborhood Hits	132	Target Neighborhood Hits	106	Shared Neighborhood Hits	89
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	4.71619e-41 (rank : 31)	NC score	0.941428 (rank : 32)
Query Neighborhood Hits	132	Target Neighborhood Hits	106	Shared Neighborhood Hits	89
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX47_HUMAN
θ value	6.15952e-41 (rank : 32)	NC score	0.950661 (rank : 14)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX41_HUMAN
θ value	3.05695e-40 (rank : 33)	NC score	0.950962 (rank : 12)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX47_MOUSE
θ value	3.99248e-40 (rank : 34)	NC score	0.950146 (rank : 15)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX54_MOUSE
θ value	2.58786e-39 (rank : 35)	NC score	0.942992 (rank : 27)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

IF4A2_HUMAN
θ value	4.41421e-39 (rank : 36)	NC score	0.940108 (rank : 35)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	4.41421e-39 (rank : 37)	NC score	0.940108 (rank : 36)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX54_HUMAN
θ value	1.57e-36 (rank : 38)	NC score	0.938514 (rank : 40)
Query Neighborhood Hits	132	Target Neighborhood Hits	170	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX27_MOUSE
θ value	2.67802e-36 (rank : 39)	NC score	0.943228 (rank : 26)
Query Neighborhood Hits	132	Target Neighborhood Hits	174	Shared Neighborhood Hits	90
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX31_HUMAN
θ value	5.96599e-36 (rank : 40)	NC score	0.938391 (rank : 41)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX27_HUMAN
θ value	1.32909e-35 (rank : 41)	NC score	0.941717 (rank : 30)
Query Neighborhood Hits	132	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX49_HUMAN
θ value	6.59618e-35 (rank : 42)	NC score	0.942464 (rank : 28)
Query Neighborhood Hits	132	Target Neighborhood Hits	223	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_MOUSE
θ value	1.46948e-34 (rank : 43)	NC score	0.945836 (rank : 21)
Query Neighborhood Hits	132	Target Neighborhood Hits	119	Shared Neighborhood Hits	91
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX28_MOUSE
θ value	6.17384e-33 (rank : 44)	NC score	0.939873 (rank : 37)
Query Neighborhood Hits	132	Target Neighborhood Hits	112	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX25_MOUSE
θ value	8.06329e-33 (rank : 45)	NC score	0.917991 (rank : 56)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX39_MOUSE
θ value	8.06329e-33 (rank : 46)	NC score	0.932181 (rank : 49)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX55_MOUSE
θ value	3.06405e-32 (rank : 47)	NC score	0.937241 (rank : 43)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_HUMAN
θ value	4.00176e-32 (rank : 48)	NC score	0.935962 (rank : 45)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX39_HUMAN
θ value	6.82597e-32 (rank : 49)	NC score	0.932369 (rank : 48)
Query Neighborhood Hits	132	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

UAP56_HUMAN
θ value	1.52067e-31 (rank : 50)	NC score	0.930490 (rank : 51)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	1.52067e-31 (rank : 51)	NC score	0.930350 (rank : 52)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX25_HUMAN
θ value	2.59387e-31 (rank : 52)	NC score	0.918337 (rank : 55)
Query Neighborhood Hits	132	Target Neighborhood Hits	93	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX1_HUMAN
θ value	3.74554e-30 (rank : 53)	NC score	0.893594 (rank : 68)
Query Neighborhood Hits	132	Target Neighborhood Hits	110	Shared Neighborhood Hits	84
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX51_MOUSE
θ value	2.42779e-29 (rank : 54)	NC score	0.924335 (rank : 54)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_MOUSE
θ value	4.14116e-29 (rank : 55)	NC score	0.893868 (rank : 67)
Query Neighborhood Hits	132	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX52_HUMAN
θ value	1.2049e-28 (rank : 56)	NC score	0.939162 (rank : 38)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DD19A_HUMAN
θ value	1.57365e-28 (rank : 57)	NC score	0.912807 (rank : 60)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DDX52_MOUSE
θ value	2.68423e-28 (rank : 58)	NC score	0.938953 (rank : 39)
Query Neighborhood Hits	132	Target Neighborhood Hits	101	Shared Neighborhood Hits	87
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DD19A_MOUSE
θ value	4.57862e-28 (rank : 59)	NC score	0.912086 (rank : 62)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	85
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	5.97985e-28 (rank : 60)	NC score	0.911702 (rank : 63)
Query Neighborhood Hits	132	Target Neighborhood Hits	109	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX51_HUMAN
θ value	7.80994e-28 (rank : 61)	NC score	0.907235 (rank : 66)
Query Neighborhood Hits	132	Target Neighborhood Hits	332	Shared Neighborhood Hits	92
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX28_HUMAN
θ value	1.62847e-25 (rank : 62)	NC score	0.931135 (rank : 50)
Query Neighborhood Hits	132	Target Neighborhood Hits	103	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX20_HUMAN
θ value	1.37858e-24 (rank : 63)	NC score	0.915999 (rank : 57)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
θ value	5.23862e-24 (rank : 64)	NC score	0.911599 (rank : 64)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX24_HUMAN
θ value	5.23862e-24 (rank : 65)	NC score	0.910536 (rank : 65)
Query Neighborhood Hits	132	Target Neighborhood Hits	190	Shared Neighborhood Hits	86
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
θ value	1.99067e-23 (rank : 66)	NC score	0.912550 (rank : 61)
Query Neighborhood Hits	132	Target Neighborhood Hits	147	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX56_HUMAN
θ value	7.0802e-21 (rank : 67)	NC score	0.915563 (rank : 58)
Query Neighborhood Hits	132	Target Neighborhood Hits	77	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
θ value	7.0802e-21 (rank : 68)	NC score	0.915177 (rank : 59)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

RECQ4_HUMAN
θ value	3.08544e-08 (rank : 69)	NC score	0.587027 (rank : 69)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	86
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ5_HUMAN
θ value	8.97725e-08 (rank : 70)	NC score	0.502587 (rank : 73)
Query Neighborhood Hits	132	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

BLM_HUMAN
θ value	2.61198e-07 (rank : 71)	NC score	0.522689 (rank : 72)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	3.41135e-07 (rank : 72)	NC score	0.534514 (rank : 71)
Query Neighborhood Hits	132	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

RECQ4_MOUSE
θ value	9.92553e-07 (rank : 73)	NC score	0.566219 (rank : 70)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	85
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ1_HUMAN
θ value	2.21117e-06 (rank : 74)	NC score	0.478902 (rank : 75)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

FANCM_HUMAN
θ value	8.40245e-06 (rank : 75)	NC score	0.460298 (rank : 78)
Query Neighborhood Hits	132	Target Neighborhood Hits	210	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	1.09739e-05 (rank : 76)	NC score	0.459614 (rank : 79)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

WRN_HUMAN
θ value	1.43324e-05 (rank : 77)	NC score	0.498627 (rank : 74)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

WRN_MOUSE
θ value	1.87187e-05 (rank : 78)	NC score	0.470366 (rank : 77)
Query Neighborhood Hits	132	Target Neighborhood Hits	295	Shared Neighborhood Hits	80
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ1_MOUSE
θ value	2.44474e-05 (rank : 79)	NC score	0.474130 (rank : 76)
Query Neighborhood Hits	132	Target Neighborhood Hits	95	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

IFIH1_HUMAN
θ value	0.000270298 (rank : 80)	NC score	0.360561 (rank : 83)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

IFIH1_MOUSE
θ value	0.000786445 (rank : 81)	NC score	0.343672 (rank : 85)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DICER_MOUSE
θ value	0.00134147 (rank : 82)	NC score	0.418611 (rank : 81)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
θ value	0.00175202 (rank : 83)	NC score	0.419063 (rank : 80)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DDX58_MOUSE
θ value	0.00298849 (rank : 84)	NC score	0.238974 (rank : 86)
Query Neighborhood Hits	132	Target Neighborhood Hits	99	Shared Neighborhood Hits	61
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

LGP2_HUMAN
θ value	0.00869519 (rank : 85)	NC score	0.348827 (rank : 84)
Query Neighborhood Hits	132	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

LGP2_MOUSE
θ value	0.0252991 (rank : 86)	NC score	0.360798 (rank : 82)
Query Neighborhood Hits	132	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

PRP16_HUMAN
θ value	0.125558 (rank : 87)	NC score	0.047259 (rank : 96)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q92620, O75212, Q96HN7	Gene names	DHX38, DDX38, KIAA0224, PRP16
Domain Architecture
Description	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.1.-) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38).

DHX29_HUMAN
θ value	0.163984 (rank : 88)	NC score	0.065888 (rank : 93)
Query Neighborhood Hits	132	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

DHX29_MOUSE
θ value	0.163984 (rank : 89)	NC score	0.065469 (rank : 94)
Query Neighborhood Hits	132	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

DHX36_MOUSE
θ value	0.163984 (rank : 90)	NC score	0.046750 (rank : 97)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

AMPH_MOUSE
θ value	0.47712 (rank : 91)	NC score	0.015117 (rank : 118)
Query Neighborhood Hits	132	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

KI21A_HUMAN
θ value	0.47712 (rank : 92)	NC score	0.005868 (rank : 124)
Query Neighborhood Hits	132	Target Neighborhood Hits	1543	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

SKIV2_HUMAN
θ value	0.47712 (rank : 93)	NC score	0.056538 (rank : 95)
Query Neighborhood Hits	132	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

CC026_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.183574 (rank : 88)
Query Neighborhood Hits	132	Target Neighborhood Hits	39	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

FILA_HUMAN
θ value	0.62314 (rank : 95)	NC score	0.039411 (rank : 101)
Query Neighborhood Hits	132	Target Neighborhood Hits	685	Shared Neighborhood Hits	22
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

LEO1_MOUSE
θ value	0.62314 (rank : 96)	NC score	0.039007 (rank : 104)
Query Neighborhood Hits	132	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MPP8_HUMAN
θ value	0.62314 (rank : 97)	NC score	0.037461 (rank : 106)
Query Neighborhood Hits	132	Target Neighborhood Hits	948	Shared Neighborhood Hits	33
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

DHX33_MOUSE
θ value	0.813845 (rank : 98)	NC score	0.042838 (rank : 98)
Query Neighborhood Hits	132	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

DHX57_HUMAN
θ value	0.813845 (rank : 99)	NC score	0.041321 (rank : 99)
Query Neighborhood Hits	132	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

DHX57_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.037032 (rank : 107)
Query Neighborhood Hits	132	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

ANR26_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.000394 (rank : 130)
Query Neighborhood Hits	132	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DHX40_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.031523 (rank : 109)
Query Neighborhood Hits	132	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PE54, Q8BPH2, Q8CD88, Q9CWN3	Gene names	Dhx40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40).

RAI14_HUMAN
θ value	1.38821 (rank : 103)	NC score	-0.003147 (rank : 136)
Query Neighborhood Hits	132	Target Neighborhood Hits	1367	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

TOP1_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.016051 (rank : 117)
Query Neighborhood Hits	132	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

AFF4_HUMAN
θ value	1.81305 (rank : 105)	NC score	0.021903 (rank : 113)
Query Neighborhood Hits	132	Target Neighborhood Hits	611	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

DHX33_HUMAN
θ value	1.81305 (rank : 106)	NC score	0.040484 (rank : 100)
Query Neighborhood Hits	132	Target Neighborhood Hits	40	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H6R0, Q4G149, Q5CZ73, Q9H5M9	Gene names	DHX33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

CCD39_MOUSE
θ value	2.36792 (rank : 107)	NC score	0.001632 (rank : 129)
Query Neighborhood Hits	132	Target Neighborhood Hits	1026	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

DHX9_HUMAN
θ value	2.36792 (rank : 108)	NC score	0.037507 (rank : 105)
Query Neighborhood Hits	132	Target Neighborhood Hits	62	Shared Neighborhood Hits	19
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

TACT_HUMAN
θ value	2.36792 (rank : 109)	NC score	0.012327 (rank : 121)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

BIN1_MOUSE
θ value	3.0926 (rank : 110)	NC score	0.012414 (rank : 120)
Query Neighborhood Hits	132	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

DDX58_HUMAN
θ value	3.0926 (rank : 111)	NC score	0.202711 (rank : 87)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DHX40_HUMAN
θ value	3.0926 (rank : 112)	NC score	0.029979 (rank : 111)
Query Neighborhood Hits	132	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IX18, Q5JPH4, Q8TC86, Q8WY53, Q9BXM1, Q9H6M9	Gene names	DHX40, DDX40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40) (ARG147) (Protein PAD).

LEO1_HUMAN
θ value	3.0926 (rank : 113)	NC score	0.036558 (rank : 108)
Query Neighborhood Hits	132	Target Neighborhood Hits	958	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PPIG_HUMAN
θ value	3.0926 (rank : 114)	NC score	0.020140 (rank : 114)
Query Neighborhood Hits	132	Target Neighborhood Hits	670	Shared Neighborhood Hits	25
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

RENT2_HUMAN
θ value	3.0926 (rank : 115)	NC score	0.008911 (rank : 123)
Query Neighborhood Hits	132	Target Neighborhood Hits	618	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

AKA12_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.019428 (rank : 115)
Query Neighborhood Hits	132	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

BIN1_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.012043 (rank : 122)
Query Neighborhood Hits	132	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

DHX34_MOUSE
θ value	4.03905 (rank : 118)	NC score	0.039375 (rank : 102)
Query Neighborhood Hits	132	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

NF2L2_MOUSE
θ value	4.03905 (rank : 119)	NC score	0.004253 (rank : 127)
Query Neighborhood Hits	132	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q60795	Gene names	Nfe2l2, Nrf-2, Nrf2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2).

NKTR_HUMAN
θ value	5.27518 (rank : 120)	NC score	0.029085 (rank : 112)
Query Neighborhood Hits	132	Target Neighborhood Hits	658	Shared Neighborhood Hits	29
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RAI14_MOUSE
θ value	5.27518 (rank : 121)	NC score	-0.001548 (rank : 133)
Query Neighborhood Hits	132	Target Neighborhood Hits	1505	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

CASC3_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.013295 (rank : 119)
Query Neighborhood Hits	132	Target Neighborhood Hits	333	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

DHX9_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.039175 (rank : 103)
Query Neighborhood Hits	132	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	O70133, O35931, O54703, Q5FWY1, Q6R5F7, Q9CSA2	Gene names	Dhx9, Ddx9
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9) (mHEL-5).

ESCO1_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.004269 (rank : 126)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z69, Q8BQI2, Q8BR47, Q922F5	Gene names	Esco1, Kiaa1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1).

NDE1_HUMAN
θ value	6.88961 (rank : 125)	NC score	-0.002338 (rank : 135)
Query Neighborhood Hits	132	Target Neighborhood Hits	823	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

REST_MOUSE
θ value	6.88961 (rank : 126)	NC score	-0.001813 (rank : 134)
Query Neighborhood Hits	132	Target Neighborhood Hits	1506	Shared Neighborhood Hits	21
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TAXB1_HUMAN
θ value	6.88961 (rank : 127)	NC score	-0.000358 (rank : 132)
Query Neighborhood Hits	132	Target Neighborhood Hits	829	Shared Neighborhood Hits	14
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

DHX34_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.031368 (rank : 110)
Query Neighborhood Hits	132	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

JIP4_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.005298 (rank : 125)
Query Neighborhood Hits	132	Target Neighborhood Hits	585	Shared Neighborhood Hits	14
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

MTF2_MOUSE
θ value	8.99809 (rank : 130)	NC score	0.002074 (rank : 128)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

POTE8_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.000011 (rank : 131)
Query Neighborhood Hits	132	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

RPTN_MOUSE
θ value	8.99809 (rank : 132)	NC score	0.016464 (rank : 116)
Query Neighborhood Hits	132	Target Neighborhood Hits	650	Shared Neighborhood Hits	23
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

CC026_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.130328 (rank : 90)
Query Neighborhood Hits	132	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

HELC1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.104133 (rank : 91)
Query Neighborhood Hits	132	Target Neighborhood Hits	71	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.070944 (rank : 92)
Query Neighborhood Hits	132	Target Neighborhood Hits	174	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

U520_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.134390 (rank : 89)
Query Neighborhood Hits	132	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

Hits sorted by NC score

DDX50_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	132
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
NC score	0.998085 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	132	Target Neighborhood Hits	137	Shared Neighborhood Hits	112
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX21_HUMAN
NC score	0.982858 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	132	Target Neighborhood Hits	308	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX21_MOUSE
NC score	0.975774 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	132	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX17_MOUSE
NC score	0.955418 (rank : 5)	θ value	7.75577e-52 (rank : 6)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	88
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.955285 (rank : 6)	θ value	7.75577e-52 (rank : 5)
Query Neighborhood Hits	132	Target Neighborhood Hits	104	Shared Neighborhood Hits	88
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX4_MOUSE
NC score	0.954974 (rank : 7)	θ value	2.49495e-50 (rank : 7)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	88
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX4_HUMAN
NC score	0.953783 (rank : 8)	θ value	7.25919e-50 (rank : 8)
Query Neighborhood Hits	132	Target Neighborhood Hits	123	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX43_HUMAN
NC score	0.953182 (rank : 9)	θ value	1.12253e-42 (rank : 25)
Query Neighborhood Hits	132	Target Neighborhood Hits	120	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX5_HUMAN
NC score	0.952157 (rank : 10)	θ value	1.788e-48 (rank : 9)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
NC score	0.951997 (rank : 11)	θ value	8.87376e-48 (rank : 10)
Query Neighborhood Hits	132	Target Neighborhood Hits	101	Shared Neighborhood Hits	89
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX41_HUMAN
NC score	0.950962 (rank : 12)	θ value	3.05695e-40 (rank : 33)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
NC score	0.950853 (rank : 13)	θ value	4.71619e-41 (rank : 27)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	87
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX47_HUMAN
NC score	0.950661 (rank : 14)	θ value	6.15952e-41 (rank : 32)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
NC score	0.950146 (rank : 15)	θ value	3.99248e-40 (rank : 34)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX53_HUMAN
NC score	0.949878 (rank : 16)	θ value	1.28137e-46 (rank : 12)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	88
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX6_HUMAN
NC score	0.948678 (rank : 17)	θ value	4.71619e-41 (rank : 28)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.948440 (rank : 18)	θ value	4.71619e-41 (rank : 29)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX48_HUMAN
NC score	0.946285 (rank : 19)	θ value	5.03882e-43 (rank : 21)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.946080 (rank : 20)	θ value	6.58091e-43 (rank : 23)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX49_MOUSE
NC score	0.945836 (rank : 21)	θ value	1.46948e-34 (rank : 43)
Query Neighborhood Hits	132	Target Neighborhood Hits	119	Shared Neighborhood Hits	91
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX3Y_MOUSE
NC score	0.943767 (rank : 22)	θ value	3.72821e-46 (rank : 17)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	93
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX3X_HUMAN
NC score	0.943509 (rank : 23)	θ value	1.28137e-46 (rank : 11)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	91
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

PL10_MOUSE
NC score	0.943468 (rank : 24)	θ value	2.85459e-46 (rank : 15)
Query Neighborhood Hits	132	Target Neighborhood Hits	120	Shared Neighborhood Hits	92
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_MOUSE
NC score	0.943331 (rank : 25)	θ value	3.72821e-46 (rank : 16)
Query Neighborhood Hits	132	Target Neighborhood Hits	117	Shared Neighborhood Hits	90
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX27_MOUSE
NC score	0.943228 (rank : 26)	θ value	2.67802e-36 (rank : 39)
Query Neighborhood Hits	132	Target Neighborhood Hits	174	Shared Neighborhood Hits	90
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX54_MOUSE
NC score	0.942992 (rank : 27)	θ value	2.58786e-39 (rank : 35)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX49_HUMAN
NC score	0.942464 (rank : 28)	θ value	6.59618e-35 (rank : 42)
Query Neighborhood Hits	132	Target Neighborhood Hits	223	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX3Y_HUMAN
NC score	0.942240 (rank : 29)	θ value	1.08474e-45 (rank : 18)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	89
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX27_HUMAN
NC score	0.941717 (rank : 30)	θ value	1.32909e-35 (rank : 41)
Query Neighborhood Hits	132	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

IF4A1_HUMAN
NC score	0.941428 (rank : 31)	θ value	4.71619e-41 (rank : 30)
Query Neighborhood Hits	132	Target Neighborhood Hits	106	Shared Neighborhood Hits	89
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.941428 (rank : 32)	θ value	4.71619e-41 (rank : 31)
Query Neighborhood Hits	132	Target Neighborhood Hits	106	Shared Neighborhood Hits	89
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX18_HUMAN
NC score	0.941254 (rank : 33)	θ value	6.58091e-43 (rank : 22)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
NC score	0.941038 (rank : 34)	θ value	8.59492e-43 (rank : 24)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

IF4A2_HUMAN
NC score	0.940108 (rank : 35)	θ value	4.41421e-39 (rank : 36)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.940108 (rank : 36)	θ value	4.41421e-39 (rank : 37)
Query Neighborhood Hits	132	Target Neighborhood Hits	102	Shared Neighborhood Hits	89
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX28_MOUSE
NC score	0.939873 (rank : 37)	θ value	6.17384e-33 (rank : 44)
Query Neighborhood Hits	132	Target Neighborhood Hits	112	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX52_HUMAN
NC score	0.939162 (rank : 38)	θ value	1.2049e-28 (rank : 56)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
NC score	0.938953 (rank : 39)	θ value	2.68423e-28 (rank : 58)
Query Neighborhood Hits	132	Target Neighborhood Hits	101	Shared Neighborhood Hits	87
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX54_HUMAN
NC score	0.938514 (rank : 40)	θ value	1.57e-36 (rank : 38)
Query Neighborhood Hits	132	Target Neighborhood Hits	170	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX31_HUMAN
NC score	0.938391 (rank : 41)	θ value	5.96599e-36 (rank : 40)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX10_HUMAN
NC score	0.937532 (rank : 42)	θ value	1.73182e-43 (rank : 20)
Query Neighborhood Hits	132	Target Neighborhood Hits	210	Shared Neighborhood Hits	90
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX55_MOUSE
NC score	0.937241 (rank : 43)	θ value	3.06405e-32 (rank : 47)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX10_MOUSE
NC score	0.937126 (rank : 44)	θ value	1.91475e-42 (rank : 26)
Query Neighborhood Hits	132	Target Neighborhood Hits	233	Shared Neighborhood Hits	93
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX55_HUMAN
NC score	0.935962 (rank : 45)	θ value	4.00176e-32 (rank : 48)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	84
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX46_HUMAN
NC score	0.935501 (rank : 46)	θ value	2.18568e-46 (rank : 13)
Query Neighborhood Hits	132	Target Neighborhood Hits	357	Shared Neighborhood Hits	100
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.933332 (rank : 47)	θ value	2.18568e-46 (rank : 14)
Query Neighborhood Hits	132	Target Neighborhood Hits	358	Shared Neighborhood Hits	101
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX39_HUMAN
NC score	0.932369 (rank : 48)	θ value	6.82597e-32 (rank : 49)
Query Neighborhood Hits	132	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
NC score	0.932181 (rank : 49)	θ value	8.06329e-33 (rank : 46)
Query Neighborhood Hits	132	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX28_HUMAN
NC score	0.931135 (rank : 50)	θ value	1.62847e-25 (rank : 62)
Query Neighborhood Hits	132	Target Neighborhood Hits	103	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

UAP56_HUMAN
NC score	0.930490 (rank : 51)	θ value	1.52067e-31 (rank : 50)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.930350 (rank : 52)	θ value	1.52067e-31 (rank : 51)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX23_HUMAN
NC score	0.924949 (rank : 53)	θ value	9.18288e-45 (rank : 19)
Query Neighborhood Hits	132	Target Neighborhood Hits	486	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX51_MOUSE
NC score	0.924335 (rank : 54)	θ value	2.42779e-29 (rank : 54)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX25_HUMAN
NC score	0.918337 (rank : 55)	θ value	2.59387e-31 (rank : 52)
Query Neighborhood Hits	132	Target Neighborhood Hits	93	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
NC score	0.917991 (rank : 56)	θ value	8.06329e-33 (rank : 45)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	83
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX20_HUMAN
NC score	0.915999 (rank : 57)	θ value	1.37858e-24 (rank : 63)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX56_HUMAN
NC score	0.915563 (rank : 58)	θ value	7.0802e-21 (rank : 67)
Query Neighborhood Hits	132	Target Neighborhood Hits	77	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
NC score	0.915177 (rank : 59)	θ value	7.0802e-21 (rank : 68)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DD19A_HUMAN
NC score	0.912807 (rank : 60)	θ value	1.57365e-28 (rank : 57)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DDX24_MOUSE
NC score	0.912550 (rank : 61)	θ value	1.99067e-23 (rank : 66)
Query Neighborhood Hits	132	Target Neighborhood Hits	147	Shared Neighborhood Hits	86
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DD19A_MOUSE
NC score	0.912086 (rank : 62)	θ value	4.57862e-28 (rank : 59)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	85
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
NC score	0.911702 (rank : 63)	θ value	5.97985e-28 (rank : 60)
Query Neighborhood Hits	132	Target Neighborhood Hits	109	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX20_MOUSE
NC score	0.911599 (rank : 64)	θ value	5.23862e-24 (rank : 64)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX24_HUMAN
NC score	0.910536 (rank : 65)	θ value	5.23862e-24 (rank : 65)
Query Neighborhood Hits	132	Target Neighborhood Hits	190	Shared Neighborhood Hits	86
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX51_HUMAN
NC score	0.907235 (rank : 66)	θ value	7.80994e-28 (rank : 61)
Query Neighborhood Hits	132	Target Neighborhood Hits	332	Shared Neighborhood Hits	92
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_MOUSE
NC score	0.893868 (rank : 67)	θ value	4.14116e-29 (rank : 55)
Query Neighborhood Hits	132	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.893594 (rank : 68)	θ value	3.74554e-30 (rank : 53)
Query Neighborhood Hits	132	Target Neighborhood Hits	110	Shared Neighborhood Hits	84
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

RECQ4_HUMAN
NC score	0.587027 (rank : 69)	θ value	3.08544e-08 (rank : 69)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	86
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.566219 (rank : 70)	θ value	9.92553e-07 (rank : 73)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	85
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

BLM_MOUSE
NC score	0.534514 (rank : 71)	θ value	3.41135e-07 (rank : 72)
Query Neighborhood Hits	132	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.522689 (rank : 72)	θ value	2.61198e-07 (rank : 71)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	74
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RECQ5_HUMAN
NC score	0.502587 (rank : 73)	θ value	8.97725e-08 (rank : 70)
Query Neighborhood Hits	132	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_HUMAN
NC score	0.498627 (rank : 74)	θ value	1.43324e-05 (rank : 77)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ1_HUMAN
NC score	0.478902 (rank : 75)	θ value	2.21117e-06 (rank : 74)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
NC score	0.474130 (rank : 76)	θ value	2.44474e-05 (rank : 79)
Query Neighborhood Hits	132	Target Neighborhood Hits	95	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

WRN_MOUSE
NC score	0.470366 (rank : 77)	θ value	1.87187e-05 (rank : 78)
Query Neighborhood Hits	132	Target Neighborhood Hits	295	Shared Neighborhood Hits	80
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

FANCM_HUMAN
NC score	0.460298 (rank : 78)	θ value	8.40245e-06 (rank : 75)
Query Neighborhood Hits	132	Target Neighborhood Hits	210	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.459614 (rank : 79)	θ value	1.09739e-05 (rank : 76)
Query Neighborhood Hits	132	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

DICER_HUMAN
NC score	0.419063 (rank : 80)	θ value	0.00175202 (rank : 83)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.418611 (rank : 81)	θ value	0.00134147 (rank : 82)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

LGP2_MOUSE
NC score	0.360798 (rank : 82)	θ value	0.0252991 (rank : 86)
Query Neighborhood Hits	132	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_HUMAN
NC score	0.360561 (rank : 83)	θ value	0.000270298 (rank : 80)
Query Neighborhood Hits	132	Target Neighborhood Hits	96	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_HUMAN
NC score	0.348827 (rank : 84)	θ value	0.00869519 (rank : 85)
Query Neighborhood Hits	132	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_MOUSE
NC score	0.343672 (rank : 85)	θ value	0.000786445 (rank : 81)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DDX58_MOUSE
NC score	0.238974 (rank : 86)	θ value	0.00298849 (rank : 84)
Query Neighborhood Hits	132	Target Neighborhood Hits	99	Shared Neighborhood Hits	61
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
NC score	0.202711 (rank : 87)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_HUMAN
NC score	0.183574 (rank : 88)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	132	Target Neighborhood Hits	39	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

U520_HUMAN
NC score	0.134390 (rank : 89)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	132	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

CC026_MOUSE
NC score	0.130328 (rank : 90)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	132	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

HELC1_HUMAN
NC score	0.104133 (rank : 91)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	132	Target Neighborhood Hits	71	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
NC score	0.070944 (rank : 92)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	132	Target Neighborhood Hits	174	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

DHX29_HUMAN
NC score	0.065888 (rank : 93)	θ value	0.163984 (rank : 88)
Query Neighborhood Hits	132	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

DHX29_MOUSE
NC score	0.065469 (rank : 94)	θ value	0.163984 (rank : 89)
Query Neighborhood Hits	132	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

SKIV2_HUMAN
NC score	0.056538 (rank : 95)	θ value	0.47712 (rank : 93)
Query Neighborhood Hits	132	Target Neighborhood Hits	45	Shared Neighborhood Hits	18
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

PRP16_HUMAN
NC score	0.047259 (rank : 96)	θ value	0.125558 (rank : 87)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	30
SwissProt Accessions	Q92620, O75212, Q96HN7	Gene names	DHX38, DDX38, KIAA0224, PRP16
Domain Architecture
Description	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.1.-) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38).

DHX36_MOUSE
NC score	0.046750 (rank : 97)	θ value	0.163984 (rank : 90)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

DHX33_MOUSE
NC score	0.042838 (rank : 98)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	132	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

DHX57_HUMAN
NC score	0.041321 (rank : 99)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	132	Target Neighborhood Hits	109	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

DHX33_HUMAN
NC score	0.040484 (rank : 100)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	132	Target Neighborhood Hits	40	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H6R0, Q4G149, Q5CZ73, Q9H5M9	Gene names	DHX33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

FILA_HUMAN
NC score	0.039411 (rank : 101)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	132	Target Neighborhood Hits	685	Shared Neighborhood Hits	22
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

DHX34_MOUSE
NC score	0.039375 (rank : 102)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	132	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX9_MOUSE
NC score	0.039175 (rank : 103)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	132	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	O70133, O35931, O54703, Q5FWY1, Q6R5F7, Q9CSA2	Gene names	Dhx9, Ddx9
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9) (mHEL-5).

LEO1_MOUSE
NC score	0.039007 (rank : 104)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	132	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

DHX9_HUMAN
NC score	0.037507 (rank : 105)	θ value	2.36792 (rank : 108)
Query Neighborhood Hits	132	Target Neighborhood Hits	62	Shared Neighborhood Hits	19
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

MPP8_HUMAN
NC score	0.037461 (rank : 106)	θ value	0.62314 (rank : 97)
Query Neighborhood Hits	132	Target Neighborhood Hits	948	Shared Neighborhood Hits	33
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

DHX57_MOUSE
NC score	0.037032 (rank : 107)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	132	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

LEO1_HUMAN
NC score	0.036558 (rank : 108)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	132	Target Neighborhood Hits	958	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

DHX40_MOUSE
NC score	0.031523 (rank : 109)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	132	Target Neighborhood Hits	40	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PE54, Q8BPH2, Q8CD88, Q9CWN3	Gene names	Dhx40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40).

DHX34_HUMAN
NC score	0.031368 (rank : 110)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	132	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX40_HUMAN
NC score	0.029979 (rank : 111)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	132	Target Neighborhood Hits	34	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IX18, Q5JPH4, Q8TC86, Q8WY53, Q9BXM1, Q9H6M9	Gene names	DHX40, DDX40
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX40 (EC 3.6.1.-) (DEAH box protein 40) (ARG147) (Protein PAD).

NKTR_HUMAN
NC score	0.029085 (rank : 112)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	132	Target Neighborhood Hits	658	Shared Neighborhood Hits	29
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

AFF4_HUMAN
NC score	0.021903 (rank : 113)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	132	Target Neighborhood Hits	611	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

PPIG_HUMAN
NC score	0.020140 (rank : 114)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	132	Target Neighborhood Hits	670	Shared Neighborhood Hits	25
SwissProt Accessions	Q13427, O00706, Q96DG9	Gene names	PPIG
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase G (EC 5.2.1.8) (Peptidyl-prolyl isomerase G) (PPIase G) (Rotamase G) (Cyclophilin G) (Clk-associating RS-cyclophilin) (CARS-cyclophilin) (CARS-Cyp) (SR-cyclophilin) (SRcyp) (SR-cyp) (CASP10).

AKA12_HUMAN
NC score	0.019428 (rank : 115)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	132	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

RPTN_MOUSE
NC score	0.016464 (rank : 116)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	132	Target Neighborhood Hits	650	Shared Neighborhood Hits	23
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

TOP1_HUMAN
NC score	0.016051 (rank : 117)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	132	Target Neighborhood Hits	207	Shared Neighborhood Hits	13
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

AMPH_MOUSE
NC score	0.015117 (rank : 118)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	132	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

CASC3_MOUSE
NC score	0.013295 (rank : 119)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	132	Target Neighborhood Hits	333	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

BIN1_MOUSE
NC score	0.012414 (rank : 120)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	132	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

TACT_HUMAN
NC score	0.012327 (rank : 121)	θ value	2.36792 (rank : 109)
Query Neighborhood Hits	132	Target Neighborhood Hits	100	Shared Neighborhood Hits	4
SwissProt Accessions	P40200	Gene names	CD96
Domain Architecture	No domain graphic available
Description	T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

BIN1_HUMAN
NC score	0.012043 (rank : 122)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	132	Target Neighborhood Hits	335	Shared Neighborhood Hits	7
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

RENT2_HUMAN
NC score	0.008911 (rank : 123)	θ value	3.0926 (rank : 115)
Query Neighborhood Hits	132	Target Neighborhood Hits	618	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

KI21A_HUMAN
NC score	0.005868 (rank : 124)	θ value	0.47712 (rank : 92)
Query Neighborhood Hits	132	Target Neighborhood Hits	1543	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

JIP4_HUMAN
NC score	0.005298 (rank : 125)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	132	Target Neighborhood Hits	585	Shared Neighborhood Hits	14
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

ESCO1_MOUSE
NC score	0.004269 (rank : 126)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q69Z69, Q8BQI2, Q8BR47, Q922F5	Gene names	Esco1, Kiaa1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1).

NF2L2_MOUSE
NC score	0.004253 (rank : 127)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	132	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q60795	Gene names	Nfe2l2, Nrf-2, Nrf2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2).

MTF2_MOUSE
NC score	0.002074 (rank : 128)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	132	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

CCD39_MOUSE
NC score	0.001632 (rank : 129)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	132	Target Neighborhood Hits	1026	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

ANR26_HUMAN
NC score	0.000394 (rank : 130)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	132	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

POTE8_HUMAN
NC score	0.000011 (rank : 131)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	132	Target Neighborhood Hits	337	Shared Neighborhood Hits	7
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

TAXB1_HUMAN
NC score	-0.000358 (rank : 132)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	132	Target Neighborhood Hits	829	Shared Neighborhood Hits	14
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

RAI14_MOUSE
NC score	-0.001548 (rank : 133)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	132	Target Neighborhood Hits	1505	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

REST_MOUSE
NC score	-0.001813 (rank : 134)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	132	Target Neighborhood Hits	1506	Shared Neighborhood Hits	21
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

NDE1_HUMAN
NC score	-0.002338 (rank : 135)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	132	Target Neighborhood Hits	823	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

RAI14_HUMAN
NC score	-0.003147 (rank : 136)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	132	Target Neighborhood Hits	1367	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).