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Network neighborhood for query Sequence : DEN2C_MOUSE

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DEN2C_MOUSE
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DEN2A_HUMAN
θ value	0 (rank : 1)	NC score	0.976062 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2A_MOUSE
θ value	0 (rank : 2)	NC score	0.980603 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C4S8, Q3TJU2, Q3TUG3, Q3UXA3	Gene names	Dennd2a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2C_HUMAN
θ value	0 (rank : 3)	NC score	0.995487 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q68D51, Q5TCX6, Q6P3R3	Gene names	DENND2C
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2C_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

ST5_HUMAN
θ value	0 (rank : 5)	NC score	0.965384 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	151	Shared Neighborhood Hits	20
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

ST5_MOUSE
θ value	0 (rank : 6)	NC score	0.967556 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

DEN2D_HUMAN
θ value	4.1872e-106 (rank : 7)	NC score	0.968684 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

DEN2D_MOUSE
θ value	5.46864e-106 (rank : 8)	NC score	0.968653 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VV4, Q3U028, Q9D831	Gene names	Dennd2d
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

DEN1A_HUMAN
θ value	1.12514e-34 (rank : 9)	NC score	0.783755 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN1A_MOUSE
θ value	1.12514e-34 (rank : 10)	NC score	0.788816 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN4C_HUMAN
θ value	3.40345e-15 (rank : 11)	NC score	0.561666 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5	Gene names	DENND4C, C9orf55
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 4C.

MYCPP_HUMAN
θ value	3.18553e-13 (rank : 12)	NC score	0.577743 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

MTMR5_HUMAN
θ value	1.2105e-12 (rank : 13)	NC score	0.422807 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	141	Shared Neighborhood Hits	16
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

MTMRD_HUMAN
θ value	1.58096e-12 (rank : 14)	NC score	0.424298 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	135	Shared Neighborhood Hits	16
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

RA6I1_MOUSE
θ value	7.84624e-12 (rank : 15)	NC score	0.551381 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

RA6I1_HUMAN
θ value	1.02475e-11 (rank : 16)	NC score	0.550453 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

KI67_HUMAN
θ value	0.163984 (rank : 17)	NC score	0.035739 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	581	Shared Neighborhood Hits	9
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

LAMB2_MOUSE
θ value	0.21417 (rank : 18)	NC score	0.008565 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

LBC_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.017928 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MINT_MOUSE
θ value	0.813845 (rank : 20)	NC score	0.018940 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	1514	Shared Neighborhood Hits	11
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SPEG_HUMAN
θ value	0.813845 (rank : 21)	NC score	0.001342 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	1762	Shared Neighborhood Hits	6
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CHD2_HUMAN
θ value	1.81305 (rank : 22)	NC score	0.009298 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

RT34_HUMAN
θ value	2.36792 (rank : 23)	NC score	0.032432 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P82930, Q9BVI7	Gene names	MRPS34
Domain Architecture	No domain graphic available
Description	Mitochondrial 28S ribosomal protein S34 (S34mt) (MRP-S34).

EXT2_MOUSE
θ value	3.0926 (rank : 24)	NC score	0.013132 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

ZO1_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.006481 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	453	Shared Neighborhood Hits	5
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

AFF1_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.021792 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	506	Shared Neighborhood Hits	8
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

DCR1A_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.010294 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIC3, Q571H5, Q6GQR6	Gene names	Dclre1a, Kiaa0086, Snm1, Snm1a
Domain Architecture	No domain graphic available
Description	DNA cross-link repair 1A protein.

MINK1_HUMAN
θ value	5.27518 (rank : 28)	NC score	-0.000873 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	1477	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

NU133_MOUSE
θ value	5.27518 (rank : 29)	NC score	0.011211 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0G9	Gene names	Nup133
Domain Architecture
Description	Nuclear pore complex protein Nup133 (Nucleoporin Nup133) (133 kDa nucleoporin).

NUMA1_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.001526 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	1523	Shared Neighborhood Hits	10
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

CCD91_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.002726 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	868	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

EXT2_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.011225 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

HTSF1_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.016930 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

PCP_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.008092 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TMR0, Q3V302, Q8BKK3, Q8R0T8	Gene names	Prcp
Domain Architecture	No domain graphic available
Description	Lysosomal Pro-X carboxypeptidase precursor (EC 3.4.16.2) (Prolylcarboxypeptidase) (PRCP) (Proline carboxypeptidase).

PDZ11_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.012449 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

TFPI1_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.008281 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

ANKY2_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.002529 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	306	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

CCNB3_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.004055 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

CLP46_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.007422 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYB9, Q8R0H7	Gene names	Clp46
Domain Architecture	No domain graphic available
Description	CAP10-like 46 kDa protein precursor.

CMGA_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.007294 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

CTND1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.003858 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

FANCE_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.030326 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

PARVB_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.005306 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

RRP5_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.008498 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

TTLL7_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.005932 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

Hits sorted by NC score

DEN2C_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2C_HUMAN
NC score	0.995487 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	58	Shared Neighborhood Hits	21
SwissProt Accessions	Q68D51, Q5TCX6, Q6P3R3	Gene names	DENND2C
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

DEN2A_MOUSE
NC score	0.980603 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C4S8, Q3TJU2, Q3TUG3, Q3UXA3	Gene names	Dennd2a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2A_HUMAN
NC score	0.976062 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DEN2D_HUMAN
NC score	0.968684 (rank : 5)	θ value	4.1872e-106 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	19	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H6A0, Q5T5V6, Q9BSU0	Gene names	DENND2D
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

DEN2D_MOUSE
NC score	0.968653 (rank : 6)	θ value	5.46864e-106 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VV4, Q3U028, Q9D831	Gene names	Dennd2d
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2D.

ST5_MOUSE
NC score	0.967556 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

ST5_HUMAN
NC score	0.965384 (rank : 8)	θ value	0 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	151	Shared Neighborhood Hits	20
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

DEN1A_MOUSE
NC score	0.788816 (rank : 9)	θ value	1.12514e-34 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K382	Gene names	Dennd1a
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

DEN1A_HUMAN
NC score	0.783755 (rank : 10)	θ value	1.12514e-34 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

MYCPP_HUMAN
NC score	0.577743 (rank : 11)	θ value	3.18553e-13 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z401, Q14655, Q86T77, Q8IVX2, Q8NB93	Gene names	MYCPBP, IRLB
Domain Architecture	No domain graphic available
Description	C-myc promoter-binding protein.

DEN4C_HUMAN
NC score	0.561666 (rank : 12)	θ value	3.40345e-15 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VZ89, Q6AI48, Q6ZUB3, Q8NCY7, Q9H6N4, Q9NUT1, Q9NWA5	Gene names	DENND4C, C9orf55
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 4C.

RA6I1_MOUSE
NC score	0.551381 (rank : 13)	θ value	7.84624e-12 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

RA6I1_HUMAN
NC score	0.550453 (rank : 14)	θ value	1.02475e-11 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

MTMRD_HUMAN
NC score	0.424298 (rank : 15)	θ value	1.58096e-12 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	135	Shared Neighborhood Hits	16
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

MTMR5_HUMAN
NC score	0.422807 (rank : 16)	θ value	1.2105e-12 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	141	Shared Neighborhood Hits	16
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

KI67_HUMAN
NC score	0.035739 (rank : 17)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	581	Shared Neighborhood Hits	9
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

RT34_HUMAN
NC score	0.032432 (rank : 18)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P82930, Q9BVI7	Gene names	MRPS34
Domain Architecture	No domain graphic available
Description	Mitochondrial 28S ribosomal protein S34 (S34mt) (MRP-S34).

FANCE_HUMAN
NC score	0.030326 (rank : 19)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

AFF1_HUMAN
NC score	0.021792 (rank : 20)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	506	Shared Neighborhood Hits	8
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

MINT_MOUSE
NC score	0.018940 (rank : 21)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	1514	Shared Neighborhood Hits	11
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

LBC_HUMAN
NC score	0.017928 (rank : 22)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

HTSF1_MOUSE
NC score	0.016930 (rank : 23)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

EXT2_MOUSE
NC score	0.013132 (rank : 24)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

PDZ11_MOUSE
NC score	0.012449 (rank : 25)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

EXT2_HUMAN
NC score	0.011225 (rank : 26)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

NU133_MOUSE
NC score	0.011211 (rank : 27)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0G9	Gene names	Nup133
Domain Architecture
Description	Nuclear pore complex protein Nup133 (Nucleoporin Nup133) (133 kDa nucleoporin).

DCR1A_MOUSE
NC score	0.010294 (rank : 28)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIC3, Q571H5, Q6GQR6	Gene names	Dclre1a, Kiaa0086, Snm1, Snm1a
Domain Architecture	No domain graphic available
Description	DNA cross-link repair 1A protein.

CHD2_HUMAN
NC score	0.009298 (rank : 29)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

LAMB2_MOUSE
NC score	0.008565 (rank : 30)	θ value	0.21417 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

RRP5_HUMAN
NC score	0.008498 (rank : 31)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q14690, Q86VQ8	Gene names	PDCD11, KIAA0185
Domain Architecture
Description	RRP5 protein homolog (Programmed cell death protein 11).

TFPI1_MOUSE
NC score	0.008281 (rank : 32)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	O54819, Q9Z2U8	Gene names	Tfpi
Domain Architecture
Description	Tissue factor pathway inhibitor precursor (TFPI) (Lipoprotein- associated coagulation inhibitor) (LACI) (Extrinsic pathway inhibitor) (EPI).

PCP_MOUSE
NC score	0.008092 (rank : 33)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TMR0, Q3V302, Q8BKK3, Q8R0T8	Gene names	Prcp
Domain Architecture	No domain graphic available
Description	Lysosomal Pro-X carboxypeptidase precursor (EC 3.4.16.2) (Prolylcarboxypeptidase) (PRCP) (Proline carboxypeptidase).

CLP46_MOUSE
NC score	0.007422 (rank : 34)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYB9, Q8R0H7	Gene names	Clp46
Domain Architecture	No domain graphic available
Description	CAP10-like 46 kDa protein precursor.

CMGA_HUMAN
NC score	0.007294 (rank : 35)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	P10645, Q96E84, Q96GL7, Q9BQB5	Gene names	CHGA
Domain Architecture
Description	Chromogranin A precursor (CgA) (Pituitary secretory protein I) (SP-I) [Contains: Vasostatin-1 (Vasostatin I); Vasostatin-2 (Vasostatin II); EA-92; ES-43; Pancreastatin; SS-18; WA-8; WE-14; LF-19; AL-11; GV-19; GR-44; ER-37].

ZO1_MOUSE
NC score	0.006481 (rank : 36)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	453	Shared Neighborhood Hits	5
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

TTLL7_HUMAN
NC score	0.005932 (rank : 37)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

PARVB_HUMAN
NC score	0.005306 (rank : 38)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

CCNB3_HUMAN
NC score	0.004055 (rank : 39)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

CTND1_HUMAN
NC score	0.003858 (rank : 40)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CCD91_HUMAN
NC score	0.002726 (rank : 41)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	868	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

ANKY2_HUMAN
NC score	0.002529 (rank : 42)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	306	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

NUMA1_HUMAN
NC score	0.001526 (rank : 43)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	1523	Shared Neighborhood Hits	10
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

SPEG_HUMAN
NC score	0.001342 (rank : 44)	θ value	0.813845 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	1762	Shared Neighborhood Hits	6
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MINK1_HUMAN
NC score	-0.000873 (rank : 45)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	1477	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).