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Network neighborhood for query Sequence : EXT2_HUMAN

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EXT2_HUMAN
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EXT2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXT2_MOUSE
θ value	0 (rank : 2)	NC score	0.999687 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

EXT1_MOUSE
θ value	1.09934e-114 (rank : 3)	NC score	0.947490 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P97464, Q61546	Gene names	Ext1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1 homolog).

EXT1_HUMAN
θ value	1.8752e-114 (rank : 4)	NC score	0.947409 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q16394, Q9BVI9	Gene names	EXT1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1).

EXTL1_HUMAN
θ value	3.23591e-74 (rank : 5)	NC score	0.922561 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL1_MOUSE
θ value	1.35953e-72 (rank : 6)	NC score	0.921863 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL3_HUMAN
θ value	2.31901e-72 (rank : 7)	NC score	0.880124 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O43909, O00225	Gene names	EXTL3, EXTL1L, EXTR1, KIAA0519
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXTL3) (Multiple exostosis-like protein 3) (Hereditary multiple exostoses gene isolog) (EXT-related protein 1).

EXTL3_MOUSE
θ value	2.31901e-72 (rank : 8)	NC score	0.883977 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVL6	Gene names	Extl3
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.-) (Multiple exostosis-like protein 3).

EXTL2_MOUSE
θ value	1.6247e-33 (rank : 9)	NC score	0.843772 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ES89, Q505Q8, Q9CX90	Gene names	Extl2, Extr2
Domain Architecture
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

EXTL2_HUMAN
θ value	2.34606e-32 (rank : 10)	NC score	0.840059 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBQ6	Gene names	EXTL2, EXTR2
Domain Architecture	No domain graphic available
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

ADAM8_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.006508 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	327	Shared Neighborhood Hits	3
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

HUG1_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.052195 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O75698	Gene names	HUG1, C10orf1
Domain Architecture	No domain graphic available
Description	Protein HUG-1 (HOX11 upstream gene 1 protein).

CDON_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.003251 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	412	Shared Neighborhood Hits	3
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

DEN2C_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.011225 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

GALM_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.020114 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K157	Gene names	Galm
Domain Architecture	No domain graphic available
Description	Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase).

HPS4_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.018715 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

PO6F2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.003293 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	639	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PSME2_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.009881 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL46, Q15129	Gene names	PSME2
Domain Architecture
Description	Proteasome activator complex subunit 2 (Proteasome activator 28- subunit beta) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex subunit beta) (REG-beta).

GP150_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.006552 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BL07, Q80UD4	Gene names	Gpr150, Pgr11
Domain Architecture
Description	Probable G-protein coupled receptor 150 (G-protein coupled receptor PGR11).

LIFR_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.005971 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

Hits sorted by NC score

EXT2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXT2_MOUSE
NC score	0.999687 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

EXT1_MOUSE
NC score	0.947490 (rank : 3)	θ value	1.09934e-114 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P97464, Q61546	Gene names	Ext1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1 homolog).

EXT1_HUMAN
NC score	0.947409 (rank : 4)	θ value	1.8752e-114 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q16394, Q9BVI9	Gene names	EXT1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1).

EXTL1_HUMAN
NC score	0.922561 (rank : 5)	θ value	3.23591e-74 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL1_MOUSE
NC score	0.921863 (rank : 6)	θ value	1.35953e-72 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL3_MOUSE
NC score	0.883977 (rank : 7)	θ value	2.31901e-72 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVL6	Gene names	Extl3
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.-) (Multiple exostosis-like protein 3).

EXTL3_HUMAN
NC score	0.880124 (rank : 8)	θ value	2.31901e-72 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O43909, O00225	Gene names	EXTL3, EXTL1L, EXTR1, KIAA0519
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXTL3) (Multiple exostosis-like protein 3) (Hereditary multiple exostoses gene isolog) (EXT-related protein 1).

EXTL2_MOUSE
NC score	0.843772 (rank : 9)	θ value	1.6247e-33 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ES89, Q505Q8, Q9CX90	Gene names	Extl2, Extr2
Domain Architecture
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

EXTL2_HUMAN
NC score	0.840059 (rank : 10)	θ value	2.34606e-32 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBQ6	Gene names	EXTL2, EXTR2
Domain Architecture	No domain graphic available
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

HUG1_HUMAN
NC score	0.052195 (rank : 11)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O75698	Gene names	HUG1, C10orf1
Domain Architecture	No domain graphic available
Description	Protein HUG-1 (HOX11 upstream gene 1 protein).

GALM_MOUSE
NC score	0.020114 (rank : 12)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K157	Gene names	Galm
Domain Architecture	No domain graphic available
Description	Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase).

HPS4_HUMAN
NC score	0.018715 (rank : 13)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

DEN2C_MOUSE
NC score	0.011225 (rank : 14)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P9P8, Q3T9X2, Q3UV30, Q80V46	Gene names	Dennd2c
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2C.

PSME2_HUMAN
NC score	0.009881 (rank : 15)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UL46, Q15129	Gene names	PSME2
Domain Architecture
Description	Proteasome activator complex subunit 2 (Proteasome activator 28- subunit beta) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex subunit beta) (REG-beta).

GP150_MOUSE
NC score	0.006552 (rank : 16)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	158	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BL07, Q80UD4	Gene names	Gpr150, Pgr11
Domain Architecture
Description	Probable G-protein coupled receptor 150 (G-protein coupled receptor PGR11).

ADAM8_HUMAN
NC score	0.006508 (rank : 17)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	327	Shared Neighborhood Hits	3
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

LIFR_HUMAN
NC score	0.005971 (rank : 18)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

PO6F2_MOUSE
NC score	0.003293 (rank : 19)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	639	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

CDON_HUMAN
NC score	0.003251 (rank : 20)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	412	Shared Neighborhood Hits	3
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.