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Network neighborhood for query Sequence : EXTL1_HUMAN

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EXTL1_HUMAN
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EXTL1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL1_MOUSE
θ value	0 (rank : 2)	NC score	0.996086 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXT1_HUMAN
θ value	7.04359e-154 (rank : 3)	NC score	0.975747 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q16394, Q9BVI9	Gene names	EXT1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1).

EXT1_MOUSE
θ value	9.19922e-154 (rank : 4)	NC score	0.975661 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P97464, Q61546	Gene names	Ext1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1 homolog).

EXT2_MOUSE
θ value	6.52014e-75 (rank : 5)	NC score	0.922791 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

EXT2_HUMAN
θ value	3.23591e-74 (rank : 6)	NC score	0.922561 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXTL3_MOUSE
θ value	1.61718e-49 (rank : 7)	NC score	0.835274 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVL6	Gene names	Extl3
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.-) (Multiple exostosis-like protein 3).

EXTL3_HUMAN
θ value	1.08726e-37 (rank : 8)	NC score	0.821794 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O43909, O00225	Gene names	EXTL3, EXTL1L, EXTR1, KIAA0519
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXTL3) (Multiple exostosis-like protein 3) (Hereditary multiple exostoses gene isolog) (EXT-related protein 1).

EXTL2_HUMAN
θ value	3.40345e-15 (rank : 9)	NC score	0.756634 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBQ6	Gene names	EXTL2, EXTR2
Domain Architecture	No domain graphic available
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

EXTL2_MOUSE
θ value	5.8054e-15 (rank : 10)	NC score	0.758362 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ES89, Q505Q8, Q9CX90	Gene names	Extl2, Extr2
Domain Architecture
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

SYNJ2_HUMAN
θ value	0.47712 (rank : 11)	NC score	0.019271 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

ARHGB_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.009549 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DLGP3_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.019807 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

GNDS_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.010718 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

PKN3_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.001671 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

DLGP3_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.018538 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

WNK1_MOUSE
θ value	6.88961 (rank : 17)	NC score	-0.000221 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1179	Shared Neighborhood Hits	4
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

VEGFC_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.007095 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	P49767	Gene names	VEGFC
Domain Architecture
Description	Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor-related protein) (VRP) (Flt4 ligand) (Flt4- L).

Hits sorted by NC score

EXTL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q92935, Q6GSC1	Gene names	EXTL1, EXTL
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXTL1_MOUSE
NC score	0.996086 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JKV7	Gene names	Extl1
Domain Architecture
Description	Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).

EXT1_HUMAN
NC score	0.975747 (rank : 3)	θ value	7.04359e-154 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	Q16394, Q9BVI9	Gene names	EXT1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT1) (Multiple exostoses protein 1).

EXT1_MOUSE
NC score	0.975661 (rank : 4)	θ value	9.19922e-154 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	P97464, Q61546	Gene names	Ext1
Domain Architecture
Description	Exostosin-1 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 1 homolog).

EXT2_MOUSE
NC score	0.922791 (rank : 5)	θ value	6.52014e-75 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

EXT2_HUMAN
NC score	0.922561 (rank : 6)	θ value	3.23591e-74 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	10
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXTL3_MOUSE
NC score	0.835274 (rank : 7)	θ value	1.61718e-49 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVL6	Gene names	Extl3
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.-) (Multiple exostosis-like protein 3).

EXTL3_HUMAN
NC score	0.821794 (rank : 8)	θ value	1.08726e-37 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	O43909, O00225	Gene names	EXTL3, EXTL1L, EXTR1, KIAA0519
Domain Architecture
Description	Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXTL3) (Multiple exostosis-like protein 3) (Hereditary multiple exostoses gene isolog) (EXT-related protein 1).

EXTL2_MOUSE
NC score	0.758362 (rank : 9)	θ value	5.8054e-15 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ES89, Q505Q8, Q9CX90	Gene names	Extl2, Extr2
Domain Architecture
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

EXTL2_HUMAN
NC score	0.756634 (rank : 10)	θ value	3.40345e-15 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UBQ6	Gene names	EXTL2, EXTR2
Domain Architecture	No domain graphic available
Description	Exostosin-like 2 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Alpha-1,4-N- acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2).

DLGP3_HUMAN
NC score	0.019807 (rank : 11)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

SYNJ2_HUMAN
NC score	0.019271 (rank : 12)	θ value	0.47712 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

DLGP3_MOUSE
NC score	0.018538 (rank : 13)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

GNDS_HUMAN
NC score	0.010718 (rank : 14)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

ARHGB_HUMAN
NC score	0.009549 (rank : 15)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	375	Shared Neighborhood Hits	3
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

VEGFC_HUMAN
NC score	0.007095 (rank : 16)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	P49767	Gene names	VEGFC
Domain Architecture
Description	Vascular endothelial growth factor C precursor (VEGF-C) (Vascular endothelial growth factor-related protein) (VRP) (Flt4 ligand) (Flt4- L).

PKN3_HUMAN
NC score	0.001671 (rank : 17)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

WNK1_MOUSE
NC score	-0.000221 (rank : 18)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1179	Shared Neighborhood Hits	4
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).