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Network neighborhood for query Sequence : NALP1_HUMAN

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NALP1_HUMAN
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NALP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	138	Target Neighborhood Hits	138	Shared Neighborhood Hits	138
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL12_HUMAN
θ value	5.08302e-128 (rank : 2)	NC score	0.927796 (rank : 2)
Query Neighborhood Hits	138	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
θ value	8.11517e-126 (rank : 3)	NC score	0.925572 (rank : 3)
Query Neighborhood Hits	138	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	3.65119e-118 (rank : 4)	NC score	0.924306 (rank : 4)
Query Neighborhood Hits	138	Target Neighborhood Hits	67	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL14_HUMAN
θ value	8.41738e-115 (rank : 5)	NC score	0.923679 (rank : 5)
Query Neighborhood Hits	138	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NAL13_HUMAN
θ value	5.14231e-88 (rank : 6)	NC score	0.919032 (rank : 8)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP4_HUMAN
θ value	1.49618e-87 (rank : 7)	NC score	0.919168 (rank : 7)
Query Neighborhood Hits	138	Target Neighborhood Hits	81	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
θ value	6.28603e-86 (rank : 8)	NC score	0.919256 (rank : 6)
Query Neighborhood Hits	138	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

CARD8_HUMAN
θ value	4.21644e-82 (rank : 9)	NC score	0.393267 (rank : 31)
Query Neighborhood Hits	138	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

NALP5_HUMAN
θ value	5.50685e-82 (rank : 10)	NC score	0.903474 (rank : 12)
Query Neighborhood Hits	138	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP7_HUMAN
θ value	3.34088e-79 (rank : 11)	NC score	0.915250 (rank : 9)
Query Neighborhood Hits	138	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP5_MOUSE
θ value	3.12697e-77 (rank : 12)	NC score	0.842772 (rank : 16)
Query Neighborhood Hits	138	Target Neighborhood Hits	560	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP6_MOUSE
θ value	1.22964e-73 (rank : 13)	NC score	0.910068 (rank : 10)
Query Neighborhood Hits	138	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP6_HUMAN
θ value	7.97034e-73 (rank : 14)	NC score	0.906399 (rank : 11)
Query Neighborhood Hits	138	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NAL10_HUMAN
θ value	5.17823e-64 (rank : 15)	NC score	0.880529 (rank : 14)
Query Neighborhood Hits	138	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL11_HUMAN
θ value	5.35859e-61 (rank : 16)	NC score	0.891391 (rank : 13)
Query Neighborhood Hits	138	Target Neighborhood Hits	66	Shared Neighborhood Hits	34
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL10_MOUSE
θ value	6.34462e-54 (rank : 17)	NC score	0.872254 (rank : 15)
Query Neighborhood Hits	138	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RINI_HUMAN
θ value	2.12192e-33 (rank : 18)	NC score	0.816649 (rank : 17)
Query Neighborhood Hits	138	Target Neighborhood Hits	78	Shared Neighborhood Hits	40
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	2.12192e-33 (rank : 19)	NC score	0.813230 (rank : 18)
Query Neighborhood Hits	138	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

ASC_MOUSE
θ value	1.42661e-21 (rank : 20)	NC score	0.439888 (rank : 29)
Query Neighborhood Hits	138	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

ASC_HUMAN
θ value	7.0802e-21 (rank : 21)	NC score	0.409423 (rank : 30)
Query Neighborhood Hits	138	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

CAR15_MOUSE
θ value	7.0802e-21 (rank : 22)	NC score	0.714552 (rank : 19)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
θ value	7.82807e-20 (rank : 23)	NC score	0.696370 (rank : 20)
Query Neighborhood Hits	138	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_HUMAN
θ value	1.2105e-12 (rank : 24)	NC score	0.651110 (rank : 22)
Query Neighborhood Hits	138	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	2.69671e-12 (rank : 25)	NC score	0.653337 (rank : 21)
Query Neighborhood Hits	138	Target Neighborhood Hits	85	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_HUMAN
θ value	1.02475e-11 (rank : 26)	NC score	0.586160 (rank : 24)
Query Neighborhood Hits	138	Target Neighborhood Hits	190	Shared Neighborhood Hits	52
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_MOUSE
θ value	1.47974e-10 (rank : 27)	NC score	0.605764 (rank : 23)
Query Neighborhood Hits	138	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

BIR1E_MOUSE
θ value	6.21693e-09 (rank : 28)	NC score	0.275852 (rank : 38)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

LRC31_HUMAN
θ value	8.11959e-09 (rank : 29)	NC score	0.513113 (rank : 25)
Query Neighborhood Hits	138	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

BIRC1_HUMAN
θ value	3.08544e-08 (rank : 30)	NC score	0.297279 (rank : 35)
Query Neighborhood Hits	138	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
θ value	8.97725e-08 (rank : 31)	NC score	0.281819 (rank : 36)
Query Neighborhood Hits	138	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
θ value	1.17247e-07 (rank : 32)	NC score	0.276047 (rank : 37)
Query Neighborhood Hits	138	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	1.53129e-07 (rank : 33)	NC score	0.269054 (rank : 39)
Query Neighborhood Hits	138	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
θ value	1.99992e-07 (rank : 34)	NC score	0.263277 (rank : 40)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

LRC45_MOUSE
θ value	1.99992e-07 (rank : 35)	NC score	0.179108 (rank : 41)
Query Neighborhood Hits	138	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
θ value	9.92553e-07 (rank : 36)	NC score	0.169959 (rank : 42)
Query Neighborhood Hits	138	Target Neighborhood Hits	933	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CF154_HUMAN
θ value	1.87187e-05 (rank : 37)	NC score	0.489583 (rank : 27)
Query Neighborhood Hits	138	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC14_HUMAN
θ value	3.19293e-05 (rank : 38)	NC score	0.156576 (rank : 43)
Query Neighborhood Hits	138	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

LRC34_MOUSE
θ value	7.1131e-05 (rank : 39)	NC score	0.471373 (rank : 28)
Query Neighborhood Hits	138	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_HUMAN
θ value	0.00020696 (rank : 40)	NC score	0.504691 (rank : 26)
Query Neighborhood Hits	138	Target Neighborhood Hits	67	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

PRA12_HUMAN
θ value	0.000602161 (rank : 41)	NC score	0.088483 (rank : 46)
Query Neighborhood Hits	138	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

CAR12_HUMAN
θ value	0.00102713 (rank : 42)	NC score	0.381207 (rank : 32)
Query Neighborhood Hits	138	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

MAPE_HUMAN
θ value	0.00228821 (rank : 43)	NC score	0.109009 (rank : 45)
Query Neighborhood Hits	138	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

PRAM7_HUMAN
θ value	0.00228821 (rank : 44)	NC score	0.079190 (rank : 49)
Query Neighborhood Hits	138	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VXH5	Gene names	PRAMEF7
Domain Architecture	No domain graphic available
Description	PRAME family member 7.

PRAM8_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.079484 (rank : 47)
Query Neighborhood Hits	138	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWM4	Gene names	PRAMEF8
Domain Architecture	No domain graphic available
Description	PRAME family member 8.

RGP1_MOUSE
θ value	0.00390308 (rank : 46)	NC score	0.302584 (rank : 34)
Query Neighborhood Hits	138	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LRC33_HUMAN
θ value	0.0431538 (rank : 47)	NC score	0.032817 (rank : 74)
Query Neighborhood Hits	138	Target Neighborhood Hits	293	Shared Neighborhood Hits	28
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

PS1C2_HUMAN
θ value	0.0563607 (rank : 48)	NC score	0.067208 (rank : 55)
Query Neighborhood Hits	138	Target Neighborhood Hits	66	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

LONM_HUMAN
θ value	0.0961366 (rank : 49)	NC score	0.051748 (rank : 69)
Query Neighborhood Hits	138	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

LRC8E_MOUSE
θ value	0.163984 (rank : 50)	NC score	0.033402 (rank : 73)
Query Neighborhood Hits	138	Target Neighborhood Hits	256	Shared Neighborhood Hits	22
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

LRC20_MOUSE
θ value	0.21417 (rank : 51)	NC score	0.039337 (rank : 70)
Query Neighborhood Hits	138	Target Neighborhood Hits	220	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CI70	Gene names	Lrrc20
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 20.

K1802_MOUSE
θ value	0.279714 (rank : 52)	NC score	0.012189 (rank : 107)
Query Neighborhood Hits	138	Target Neighborhood Hits	1596	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LGR5_HUMAN
θ value	0.365318 (rank : 53)	NC score	0.018646 (rank : 90)
Query Neighborhood Hits	138	Target Neighborhood Hits	452	Shared Neighborhood Hits	25
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

LRC32_HUMAN
θ value	0.365318 (rank : 54)	NC score	0.021837 (rank : 86)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	23
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

LRC8E_HUMAN
θ value	0.365318 (rank : 55)	NC score	0.029620 (rank : 77)
Query Neighborhood Hits	138	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NSJ5, Q2YDY3, Q7L236, Q8N3B0, Q9H5H8	Gene names	LRRC8E
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

PIDD_HUMAN
θ value	0.365318 (rank : 56)	NC score	0.030905 (rank : 76)
Query Neighborhood Hits	138	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

ALEX_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.027337 (rank : 80)
Query Neighborhood Hits	138	Target Neighborhood Hits	197	Shared Neighborhood Hits	15
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

MAGAA_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.009319 (rank : 117)
Query Neighborhood Hits	138	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	P43363	Gene names	MAGEA10, MAGE10
Domain Architecture
Description	Melanoma-associated antigen 10 (MAGE-10 antigen).

NCOR2_HUMAN
θ value	0.813845 (rank : 59)	NC score	0.014970 (rank : 101)
Query Neighborhood Hits	138	Target Neighborhood Hits	870	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PRG4_HUMAN
θ value	0.813845 (rank : 60)	NC score	0.014728 (rank : 103)
Query Neighborhood Hits	138	Target Neighborhood Hits	764	Shared Neighborhood Hits	24
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PTPRD_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.003355 (rank : 139)
Query Neighborhood Hits	138	Target Neighborhood Hits	485	Shared Neighborhood Hits	4
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CCD22_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.016254 (rank : 97)
Query Neighborhood Hits	138	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

MAGE1_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.010132 (rank : 110)
Query Neighborhood Hits	138	Target Neighborhood Hits	1389	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SP5_MOUSE
θ value	1.06291 (rank : 64)	NC score	-0.000703 (rank : 150)
Query Neighborhood Hits	138	Target Neighborhood Hits	821	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

SYNJ1_MOUSE
θ value	1.06291 (rank : 65)	NC score	0.018473 (rank : 92)
Query Neighborhood Hits	138	Target Neighborhood Hits	516	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

UBP42_HUMAN
θ value	1.06291 (rank : 66)	NC score	0.009289 (rank : 118)
Query Neighborhood Hits	138	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

CEP68_HUMAN
θ value	1.38821 (rank : 67)	NC score	0.020164 (rank : 88)
Query Neighborhood Hits	138	Target Neighborhood Hits	128	Shared Neighborhood Hits	11
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CJ078_MOUSE
θ value	1.38821 (rank : 68)	NC score	0.018119 (rank : 93)
Query Neighborhood Hits	138	Target Neighborhood Hits	559	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

HIP1R_MOUSE
θ value	1.38821 (rank : 69)	NC score	0.008198 (rank : 125)
Query Neighborhood Hits	138	Target Neighborhood Hits	959	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

LRC8B_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.025876 (rank : 81)
Query Neighborhood Hits	138	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P9F7, Q6UY21, Q8N106, Q92627	Gene names	LRRC8B, KIAA0231
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8B (T-cell activation leucine repeat-rich protein).

ZC3H3_HUMAN
θ value	1.38821 (rank : 71)	NC score	0.017054 (rank : 96)
Query Neighborhood Hits	138	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXZ2, Q14163, Q8N4E2, Q9BUS4	Gene names	ZC3H3, KIAA0150, ZC3HDC3
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

BCLF1_MOUSE
θ value	1.81305 (rank : 72)	NC score	0.021975 (rank : 84)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

CD45_MOUSE
θ value	1.81305 (rank : 73)	NC score	0.007260 (rank : 129)
Query Neighborhood Hits	138	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

LRC57_HUMAN
θ value	1.81305 (rank : 74)	NC score	0.035744 (rank : 71)
Query Neighborhood Hits	138	Target Neighborhood Hits	271	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N9N7, Q7Z2Z6, Q8N1T6	Gene names	LRRC57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

LRC8C_MOUSE
θ value	1.81305 (rank : 75)	NC score	0.027361 (rank : 79)
Query Neighborhood Hits	138	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R502, Q3TEP9, Q8C296, Q8R0N7, Q8R3G5	Gene names	Lrrc8c, Ad158
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8C (Protein AD158).

SP5_HUMAN
θ value	1.81305 (rank : 76)	NC score	-0.001135 (rank : 151)
Query Neighborhood Hits	138	Target Neighborhood Hits	832	Shared Neighborhood Hits	13
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

UBE4B_HUMAN
θ value	1.81305 (rank : 77)	NC score	0.014899 (rank : 102)
Query Neighborhood Hits	138	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

KCT2_MOUSE
θ value	2.36792 (rank : 78)	NC score	0.024798 (rank : 82)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

NPHP4_HUMAN
θ value	2.36792 (rank : 79)	NC score	0.014450 (rank : 104)
Query Neighborhood Hits	138	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	O75161	Gene names	NPHP4, KIAA0673
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

PCD20_HUMAN
θ value	2.36792 (rank : 80)	NC score	0.001067 (rank : 146)
Query Neighborhood Hits	138	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N6Y1, Q8NDN4, Q9NRT9	Gene names	PCDH20
Domain Architecture	No domain graphic available
Description	Protocadherin-20 precursor (Protocadherin-13).

SMOO_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.015018 (rank : 100)
Query Neighborhood Hits	138	Target Neighborhood Hits	391	Shared Neighborhood Hits	19
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SYNJ1_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.017943 (rank : 94)
Query Neighborhood Hits	138	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TLR3_MOUSE
θ value	2.36792 (rank : 83)	NC score	0.017561 (rank : 95)
Query Neighborhood Hits	138	Target Neighborhood Hits	298	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TYK2_HUMAN
θ value	2.36792 (rank : 84)	NC score	-0.003037 (rank : 155)
Query Neighborhood Hits	138	Target Neighborhood Hits	841	Shared Neighborhood Hits	5
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BCAR1_HUMAN
θ value	3.0926 (rank : 85)	NC score	0.007615 (rank : 128)
Query Neighborhood Hits	138	Target Neighborhood Hits	554	Shared Neighborhood Hits	18
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

HCN4_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.006133 (rank : 134)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

LRC59_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.021892 (rank : 85)
Query Neighborhood Hits	138	Target Neighborhood Hits	398	Shared Neighborhood Hits	22
SwissProt Accessions	Q96AG4, Q9P189	Gene names	LRRC59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

LRC59_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.021760 (rank : 87)
Query Neighborhood Hits	138	Target Neighborhood Hits	415	Shared Neighborhood Hits	23
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

LRC8C_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.027667 (rank : 78)
Query Neighborhood Hits	138	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDW0, Q9H075	Gene names	LRRC8C, AD158
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8C (Protein AD158).

LRRK1_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.002578 (rank : 143)
Query Neighborhood Hits	138	Target Neighborhood Hits	1237	Shared Neighborhood Hits	23
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MARK1_MOUSE
θ value	3.0926 (rank : 91)	NC score	-0.004038 (rank : 157)
Query Neighborhood Hits	138	Target Neighborhood Hits	886	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MLL2_HUMAN
θ value	3.0926 (rank : 92)	NC score	0.007635 (rank : 127)
Query Neighborhood Hits	138	Target Neighborhood Hits	1788	Shared Neighborhood Hits	40
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TRH_MOUSE
θ value	3.0926 (rank : 93)	NC score	0.019741 (rank : 89)
Query Neighborhood Hits	138	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q62361, Q7TMT4	Gene names	Trh
Domain Architecture	No domain graphic available
Description	Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin (Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor) (TRF) (TSH-releasing factor) (Protirelin)].

AAK1_MOUSE
θ value	4.03905 (rank : 94)	NC score	-0.001805 (rank : 153)
Query Neighborhood Hits	138	Target Neighborhood Hits	1051	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CN032_HUMAN
θ value	4.03905 (rank : 95)	NC score	0.015992 (rank : 99)
Query Neighborhood Hits	138	Target Neighborhood Hits	267	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CSKI1_HUMAN
θ value	4.03905 (rank : 96)	NC score	0.004211 (rank : 138)
Query Neighborhood Hits	138	Target Neighborhood Hits	997	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FMNL_HUMAN
θ value	4.03905 (rank : 97)	NC score	0.009257 (rank : 119)
Query Neighborhood Hits	138	Target Neighborhood Hits	529	Shared Neighborhood Hits	19
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GA2L1_MOUSE
θ value	4.03905 (rank : 98)	NC score	0.010104 (rank : 111)
Query Neighborhood Hits	138	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

GATA2_MOUSE
θ value	4.03905 (rank : 99)	NC score	0.009111 (rank : 120)
Query Neighborhood Hits	138	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O09100	Gene names	Gata2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

KTN1_MOUSE
θ value	4.03905 (rank : 100)	NC score	0.001815 (rank : 145)
Query Neighborhood Hits	138	Target Neighborhood Hits	1324	Shared Neighborhood Hits	10
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LEG3_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.008669 (rank : 123)
Query Neighborhood Hits	138	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

MINT_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.009522 (rank : 115)
Query Neighborhood Hits	138	Target Neighborhood Hits	1291	Shared Neighborhood Hits	29
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SMAD5_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.005239 (rank : 136)
Query Neighborhood Hits	138	Target Neighborhood Hits	74	Shared Neighborhood Hits	6
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

TCGAP_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.005584 (rank : 135)
Query Neighborhood Hits	138	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

YTDC1_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.016219 (rank : 98)
Query Neighborhood Hits	138	Target Neighborhood Hits	458	Shared Neighborhood Hits	6
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ARI1B_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.008206 (rank : 124)
Query Neighborhood Hits	138	Target Neighborhood Hits	567	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

BCLF1_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.018547 (rank : 91)
Query Neighborhood Hits	138	Target Neighborhood Hits	298	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

LRC57_MOUSE
θ value	5.27518 (rank : 108)	NC score	0.034339 (rank : 72)
Query Neighborhood Hits	138	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D1G5, Q9DC95	Gene names	Lrrc57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

MADCA_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.013907 (rank : 105)
Query Neighborhood Hits	138	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MUC1_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.009733 (rank : 113)
Query Neighborhood Hits	138	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

DIRA3_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.006199 (rank : 132)
Query Neighborhood Hits	138	Target Neighborhood Hits	241	Shared Neighborhood Hits	7
SwissProt Accessions	O95661	Gene names	DIRAS3, ARHI, NOEY2, RHOI
Domain Architecture
Description	GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI).

GATA2_HUMAN
θ value	6.88961 (rank : 112)	NC score	0.007988 (rank : 126)
Query Neighborhood Hits	138	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

KAISO_MOUSE
θ value	6.88961 (rank : 113)	NC score	-0.002277 (rank : 154)
Query Neighborhood Hits	138	Target Neighborhood Hits	821	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BN78, Q8C226, Q9WTZ7	Gene names	Zbtb33, Kaiso
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

MEGF9_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.002877 (rank : 142)
Query Neighborhood Hits	138	Target Neighborhood Hits	896	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MYO15_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.002975 (rank : 141)
Query Neighborhood Hits	138	Target Neighborhood Hits	671	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NCOR2_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.012674 (rank : 106)
Query Neighborhood Hits	138	Target Neighborhood Hits	790	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

OGFR_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.006559 (rank : 131)
Query Neighborhood Hits	138	Target Neighborhood Hits	1582	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ORC3_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.008789 (rank : 121)
Query Neighborhood Hits	138	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

PTPRD_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.001827 (rank : 144)
Query Neighborhood Hits	138	Target Neighborhood Hits	491	Shared Neighborhood Hits	5
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

ANK1_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.000053 (rank : 149)
Query Neighborhood Hits	138	Target Neighborhood Hits	430	Shared Neighborhood Hits	7
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

BCL3_MOUSE
θ value	8.99809 (rank : 121)	NC score	0.000457 (rank : 148)
Query Neighborhood Hits	138	Target Neighborhood Hits	388	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

BLNK_HUMAN
θ value	8.99809 (rank : 122)	NC score	0.006173 (rank : 133)
Query Neighborhood Hits	138	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CI079_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.009481 (rank : 116)
Query Neighborhood Hits	138	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CIC_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.004816 (rank : 137)
Query Neighborhood Hits	138	Target Neighborhood Hits	742	Shared Neighborhood Hits	21
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

EMIL3_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.006654 (rank : 130)
Query Neighborhood Hits	138	Target Neighborhood Hits	249	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NT22, Q76KT4	Gene names	EMILIN3, C20orf130, EMILIN5
Domain Architecture	No domain graphic available
Description	EMILIN-3 precursor (EMILIN-5) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5).

F100A_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.008705 (rank : 122)
Query Neighborhood Hits	138	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TB05, Q71MF6	Gene names	FAM100A
Domain Architecture	No domain graphic available
Description	Protein FAM100A.

GLI3_HUMAN
θ value	8.99809 (rank : 127)	NC score	-0.003623 (rank : 156)
Query Neighborhood Hits	138	Target Neighborhood Hits	871	Shared Neighborhood Hits	8
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

GP1BA_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.022842 (rank : 83)
Query Neighborhood Hits	138	Target Neighborhood Hits	407	Shared Neighborhood Hits	29
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

KCNH4_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.003196 (rank : 140)
Query Neighborhood Hits	138	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

LAMC2_MOUSE
θ value	8.99809 (rank : 130)	NC score	0.000546 (rank : 147)
Query Neighborhood Hits	138	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

LRC20_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.030921 (rank : 75)
Query Neighborhood Hits	138	Target Neighborhood Hits	226	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCA0, Q5T6D4, Q5T6D6, Q9NVA6, Q9NVG3	Gene names	LRRC20
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 20.

MOD5_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.010762 (rank : 109)
Query Neighborhood Hits	138	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

NACAM_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.009536 (rank : 114)
Query Neighborhood Hits	138	Target Neighborhood Hits	1866	Shared Neighborhood Hits	50
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NTR2_MOUSE
θ value	8.99809 (rank : 134)	NC score	-0.001558 (rank : 152)
Query Neighborhood Hits	138	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	P70310	Gene names	Ntsr2
Domain Architecture
Description	Neurotensin receptor type 2 (NT-R-2) (Low-affinity levocabastine- sensitive neurotensin receptor) (NTRL).

NU214_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.009737 (rank : 112)
Query Neighborhood Hits	138	Target Neighborhood Hits	657	Shared Neighborhood Hits	21
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PRAM5_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.067847 (rank : 53)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q5TYX0	Gene names	PRAMEF5
Domain Architecture	No domain graphic available
Description	PRAME family member 5.

PRAM6_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.067920 (rank : 52)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VXH4	Gene names	PRAMEF6
Domain Architecture	No domain graphic available
Description	PRAME family member 6.

TMM28_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.011240 (rank : 108)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O75949	Gene names	TMEM28, TED
Domain Architecture	No domain graphic available
Description	Transmembrane protein 28 (TED protein).

BIRC2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.068462 (rank : 51)
Query Neighborhood Hits	138	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.073854 (rank : 50)
Query Neighborhood Hits	138	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.067001 (rank : 56)
Query Neighborhood Hits	138	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.063420 (rank : 61)
Query Neighborhood Hits	138	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.066293 (rank : 57)
Query Neighborhood Hits	138	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.067683 (rank : 54)
Query Neighborhood Hits	138	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC5_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.063879 (rank : 59)
Query Neighborhood Hits	138	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.062743 (rank : 62)
Query Neighborhood Hits	138	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC7_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.060033 (rank : 64)
Query Neighborhood Hits	138	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC8_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.054376 (rank : 67)
Query Neighborhood Hits	138	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

CD14_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.053685 (rank : 68)
Query Neighborhood Hits	138	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

MEFV_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.079412 (rank : 48)
Query Neighborhood Hits	138	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.145886 (rank : 44)
Query Neighborhood Hits	138	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

PRAM1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.056281 (rank : 65)
Query Neighborhood Hits	138	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

PRAM2_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.055394 (rank : 66)
Query Neighborhood Hits	138	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O60811	Gene names	PRAMEF2
Domain Architecture	No domain graphic available
Description	PRAME family member 2.

PRAM3_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.060668 (rank : 63)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

PRAM4_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.064236 (rank : 58)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	O60810, Q5LJB5	Gene names	PRAMEF4
Domain Architecture	No domain graphic available
Description	PRAME family member 4.

PRAM9_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.063485 (rank : 60)
Query Neighborhood Hits	138	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	Q5VWM5	Gene names	PRAMEF9
Domain Architecture	No domain graphic available
Description	PRAME family member 9.

RGP1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.302938 (rank : 33)
Query Neighborhood Hits	138	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

Hits sorted by NC score

NALP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	138	Target Neighborhood Hits	138	Shared Neighborhood Hits	138
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL12_HUMAN
NC score	0.927796 (rank : 2)	θ value	5.08302e-128 (rank : 2)
Query Neighborhood Hits	138	Target Neighborhood Hits	96	Shared Neighborhood Hits	47
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
NC score	0.925572 (rank : 3)	θ value	8.11517e-126 (rank : 3)
Query Neighborhood Hits	138	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
NC score	0.924306 (rank : 4)	θ value	3.65119e-118 (rank : 4)
Query Neighborhood Hits	138	Target Neighborhood Hits	67	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL14_HUMAN
NC score	0.923679 (rank : 5)	θ value	8.41738e-115 (rank : 5)
Query Neighborhood Hits	138	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP2_HUMAN
NC score	0.919256 (rank : 6)	θ value	6.28603e-86 (rank : 8)
Query Neighborhood Hits	138	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP4_HUMAN
NC score	0.919168 (rank : 7)	θ value	1.49618e-87 (rank : 7)
Query Neighborhood Hits	138	Target Neighborhood Hits	81	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL13_HUMAN
NC score	0.919032 (rank : 8)	θ value	5.14231e-88 (rank : 6)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	39
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP7_HUMAN
NC score	0.915250 (rank : 9)	θ value	3.34088e-79 (rank : 11)
Query Neighborhood Hits	138	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP6_MOUSE
NC score	0.910068 (rank : 10)	θ value	1.22964e-73 (rank : 13)
Query Neighborhood Hits	138	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP6_HUMAN
NC score	0.906399 (rank : 11)	θ value	7.97034e-73 (rank : 14)
Query Neighborhood Hits	138	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP5_HUMAN
NC score	0.903474 (rank : 12)	θ value	5.50685e-82 (rank : 10)
Query Neighborhood Hits	138	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL11_HUMAN
NC score	0.891391 (rank : 13)	θ value	5.35859e-61 (rank : 16)
Query Neighborhood Hits	138	Target Neighborhood Hits	66	Shared Neighborhood Hits	34
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL10_HUMAN
NC score	0.880529 (rank : 14)	θ value	5.17823e-64 (rank : 15)
Query Neighborhood Hits	138	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.872254 (rank : 15)	θ value	6.34462e-54 (rank : 17)
Query Neighborhood Hits	138	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NALP5_MOUSE
NC score	0.842772 (rank : 16)	θ value	3.12697e-77 (rank : 12)
Query Neighborhood Hits	138	Target Neighborhood Hits	560	Shared Neighborhood Hits	51
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.816649 (rank : 17)	θ value	2.12192e-33 (rank : 18)
Query Neighborhood Hits	138	Target Neighborhood Hits	78	Shared Neighborhood Hits	40
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.813230 (rank : 18)	θ value	2.12192e-33 (rank : 19)
Query Neighborhood Hits	138	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
NC score	0.714552 (rank : 19)	θ value	7.0802e-21 (rank : 22)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.696370 (rank : 20)	θ value	7.82807e-20 (rank : 23)
Query Neighborhood Hits	138	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
NC score	0.653337 (rank : 21)	θ value	2.69671e-12 (rank : 25)
Query Neighborhood Hits	138	Target Neighborhood Hits	85	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.651110 (rank : 22)	θ value	1.2105e-12 (rank : 24)
Query Neighborhood Hits	138	Target Neighborhood Hits	102	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_MOUSE
NC score	0.605764 (rank : 23)	θ value	1.47974e-10 (rank : 27)
Query Neighborhood Hits	138	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.586160 (rank : 24)	θ value	1.02475e-11 (rank : 26)
Query Neighborhood Hits	138	Target Neighborhood Hits	190	Shared Neighborhood Hits	52
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC31_HUMAN
NC score	0.513113 (rank : 25)	θ value	8.11959e-09 (rank : 29)
Query Neighborhood Hits	138	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_HUMAN
NC score	0.504691 (rank : 26)	θ value	0.00020696 (rank : 40)
Query Neighborhood Hits	138	Target Neighborhood Hits	67	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
NC score	0.489583 (rank : 27)	θ value	1.87187e-05 (rank : 37)
Query Neighborhood Hits	138	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC34_MOUSE
NC score	0.471373 (rank : 28)	θ value	7.1131e-05 (rank : 39)
Query Neighborhood Hits	138	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

ASC_MOUSE
NC score	0.439888 (rank : 29)	θ value	1.42661e-21 (rank : 20)
Query Neighborhood Hits	138	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

ASC_HUMAN
NC score	0.409423 (rank : 30)	θ value	7.0802e-21 (rank : 21)
Query Neighborhood Hits	138	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

CARD8_HUMAN
NC score	0.393267 (rank : 31)	θ value	4.21644e-82 (rank : 9)
Query Neighborhood Hits	138	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

CAR12_HUMAN
NC score	0.381207 (rank : 32)	θ value	0.00102713 (rank : 42)
Query Neighborhood Hits	138	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

RGP1_HUMAN
NC score	0.302938 (rank : 33)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	138	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.302584 (rank : 34)	θ value	0.00390308 (rank : 46)
Query Neighborhood Hits	138	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

BIRC1_HUMAN
NC score	0.297279 (rank : 35)	θ value	3.08544e-08 (rank : 30)
Query Neighborhood Hits	138	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.281819 (rank : 36)	θ value	8.97725e-08 (rank : 31)
Query Neighborhood Hits	138	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.276047 (rank : 37)	θ value	1.17247e-07 (rank : 32)
Query Neighborhood Hits	138	Target Neighborhood Hits	88	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.275852 (rank : 38)	θ value	6.21693e-09 (rank : 28)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.269054 (rank : 39)	θ value	1.53129e-07 (rank : 33)
Query Neighborhood Hits	138	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.263277 (rank : 40)	θ value	1.99992e-07 (rank : 34)
Query Neighborhood Hits	138	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

LRC45_MOUSE
NC score	0.179108 (rank : 41)	θ value	1.99992e-07 (rank : 35)
Query Neighborhood Hits	138	Target Neighborhood Hits	959	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.169959 (rank : 42)	θ value	9.92553e-07 (rank : 36)
Query Neighborhood Hits	138	Target Neighborhood Hits	933	Shared Neighborhood Hits	38
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC14_HUMAN
NC score	0.156576 (rank : 43)	θ value	3.19293e-05 (rank : 38)
Query Neighborhood Hits	138	Target Neighborhood Hits	57	Shared Neighborhood Hits	26
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

MEFV_MOUSE
NC score	0.145886 (rank : 44)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	138	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

MAPE_HUMAN
NC score	0.109009 (rank : 45)	θ value	0.00228821 (rank : 43)
Query Neighborhood Hits	138	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

PRA12_HUMAN
NC score	0.088483 (rank : 46)	θ value	0.000602161 (rank : 41)
Query Neighborhood Hits	138	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

PRAM8_HUMAN
NC score	0.079484 (rank : 47)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	138	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWM4	Gene names	PRAMEF8
Domain Architecture	No domain graphic available
Description	PRAME family member 8.

MEFV_HUMAN
NC score	0.079412 (rank : 48)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	138	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

PRAM7_HUMAN
NC score	0.079190 (rank : 49)	θ value	0.00228821 (rank : 44)
Query Neighborhood Hits	138	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VXH5	Gene names	PRAMEF7
Domain Architecture	No domain graphic available
Description	PRAME family member 7.

BIRC2_MOUSE
NC score	0.073854 (rank : 50)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	138	Target Neighborhood Hits	137	Shared Neighborhood Hits	11
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC2_HUMAN
NC score	0.068462 (rank : 51)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	138	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

PRAM6_HUMAN
NC score	0.067920 (rank : 52)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VXH4	Gene names	PRAMEF6
Domain Architecture	No domain graphic available
Description	PRAME family member 6.

PRAM5_HUMAN
NC score	0.067847 (rank : 53)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	13
SwissProt Accessions	Q5TYX0	Gene names	PRAMEF5
Domain Architecture	No domain graphic available
Description	PRAME family member 5.

BIRC4_MOUSE
NC score	0.067683 (rank : 54)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	138	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

PS1C2_HUMAN
NC score	0.067208 (rank : 55)	θ value	0.0563607 (rank : 48)
Query Neighborhood Hits	138	Target Neighborhood Hits	66	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

BIRC3_HUMAN
NC score	0.067001 (rank : 56)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	138	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC4_HUMAN
NC score	0.066293 (rank : 57)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	138	Target Neighborhood Hits	89	Shared Neighborhood Hits	6
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

PRAM4_HUMAN
NC score	0.064236 (rank : 58)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	O60810, Q5LJB5	Gene names	PRAMEF4
Domain Architecture	No domain graphic available
Description	PRAME family member 4.

BIRC5_HUMAN
NC score	0.063879 (rank : 59)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	138	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

PRAM9_HUMAN
NC score	0.063485 (rank : 60)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	138	Target Neighborhood Hits	27	Shared Neighborhood Hits	11
SwissProt Accessions	Q5VWM5	Gene names	PRAMEF9
Domain Architecture	No domain graphic available
Description	PRAME family member 9.

BIRC3_MOUSE
NC score	0.063420 (rank : 61)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	138	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC5_MOUSE
NC score	0.062743 (rank : 62)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	138	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

PRAM3_HUMAN
NC score	0.060668 (rank : 63)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

BIRC7_HUMAN
NC score	0.060033 (rank : 64)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	138	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

PRAM1_HUMAN
NC score	0.056281 (rank : 65)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	138	Target Neighborhood Hits	17	Shared Neighborhood Hits	10
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

PRAM2_HUMAN
NC score	0.055394 (rank : 66)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	138	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	O60811	Gene names	PRAMEF2
Domain Architecture	No domain graphic available
Description	PRAME family member 2.

BIRC8_HUMAN
NC score	0.054376 (rank : 67)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	138	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

CD14_MOUSE
NC score	0.053685 (rank : 68)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	138	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

LONM_HUMAN
NC score	0.051748 (rank : 69)	θ value	0.0961366 (rank : 49)
Query Neighborhood Hits	138	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

LRC20_MOUSE
NC score	0.039337 (rank : 70)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	138	Target Neighborhood Hits	220	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CI70	Gene names	Lrrc20
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 20.

LRC57_HUMAN
NC score	0.035744 (rank : 71)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	138	Target Neighborhood Hits	271	Shared Neighborhood Hits	28
SwissProt Accessions	Q8N9N7, Q7Z2Z6, Q8N1T6	Gene names	LRRC57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

LRC57_MOUSE
NC score	0.034339 (rank : 72)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	138	Target Neighborhood Hits	267	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D1G5, Q9DC95	Gene names	Lrrc57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

LRC8E_MOUSE
NC score	0.033402 (rank : 73)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	138	Target Neighborhood Hits	256	Shared Neighborhood Hits	22
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

LRC33_HUMAN
NC score	0.032817 (rank : 74)	θ value	0.0431538 (rank : 47)
Query Neighborhood Hits	138	Target Neighborhood Hits	293	Shared Neighborhood Hits	28
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC20_HUMAN
NC score	0.030921 (rank : 75)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	138	Target Neighborhood Hits	226	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TCA0, Q5T6D4, Q5T6D6, Q9NVA6, Q9NVG3	Gene names	LRRC20
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 20.

PIDD_HUMAN
NC score	0.030905 (rank : 76)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	138	Target Neighborhood Hits	271	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

LRC8E_HUMAN
NC score	0.029620 (rank : 77)	θ value	0.365318 (rank : 55)
Query Neighborhood Hits	138	Target Neighborhood Hits	259	Shared Neighborhood Hits	21
SwissProt Accessions	Q6NSJ5, Q2YDY3, Q7L236, Q8N3B0, Q9H5H8	Gene names	LRRC8E
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

LRC8C_HUMAN
NC score	0.027667 (rank : 78)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	138	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDW0, Q9H075	Gene names	LRRC8C, AD158
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8C (Protein AD158).

LRC8C_MOUSE
NC score	0.027361 (rank : 79)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	138	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R502, Q3TEP9, Q8C296, Q8R0N7, Q8R3G5	Gene names	Lrrc8c, Ad158
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8C (Protein AD158).

ALEX_MOUSE
NC score	0.027337 (rank : 80)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	138	Target Neighborhood Hits	197	Shared Neighborhood Hits	15
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

LRC8B_HUMAN
NC score	0.025876 (rank : 81)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	138	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q6P9F7, Q6UY21, Q8N106, Q92627	Gene names	LRRC8B, KIAA0231
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8B (T-cell activation leucine repeat-rich protein).

KCT2_MOUSE
NC score	0.024798 (rank : 82)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	138	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

GP1BA_HUMAN
NC score	0.022842 (rank : 83)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	138	Target Neighborhood Hits	407	Shared Neighborhood Hits	29
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

BCLF1_MOUSE
NC score	0.021975 (rank : 84)	θ value	1.81305 (rank : 72)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

LRC59_HUMAN
NC score	0.021892 (rank : 85)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	138	Target Neighborhood Hits	398	Shared Neighborhood Hits	22
SwissProt Accessions	Q96AG4, Q9P189	Gene names	LRRC59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

LRC32_HUMAN
NC score	0.021837 (rank : 86)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	23
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

LRC59_MOUSE
NC score	0.021760 (rank : 87)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	138	Target Neighborhood Hits	415	Shared Neighborhood Hits	23
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

CEP68_HUMAN
NC score	0.020164 (rank : 88)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	138	Target Neighborhood Hits	128	Shared Neighborhood Hits	11
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

TRH_MOUSE
NC score	0.019741 (rank : 89)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	138	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q62361, Q7TMT4	Gene names	Trh
Domain Architecture	No domain graphic available
Description	Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin (Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor) (TRF) (TSH-releasing factor) (Protirelin)].

LGR5_HUMAN
NC score	0.018646 (rank : 90)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	138	Target Neighborhood Hits	452	Shared Neighborhood Hits	25
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

BCLF1_HUMAN
NC score	0.018547 (rank : 91)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	138	Target Neighborhood Hits	298	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

SYNJ1_MOUSE
NC score	0.018473 (rank : 92)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	138	Target Neighborhood Hits	516	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CJ078_MOUSE
NC score	0.018119 (rank : 93)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	138	Target Neighborhood Hits	559	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

SYNJ1_HUMAN
NC score	0.017943 (rank : 94)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	138	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TLR3_MOUSE
NC score	0.017561 (rank : 95)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	138	Target Neighborhood Hits	298	Shared Neighborhood Hits	25
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

ZC3H3_HUMAN
NC score	0.017054 (rank : 96)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	138	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXZ2, Q14163, Q8N4E2, Q9BUS4	Gene names	ZC3H3, KIAA0150, ZC3HDC3
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

CCD22_MOUSE
NC score	0.016254 (rank : 97)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	138	Target Neighborhood Hits	268	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

YTDC1_HUMAN
NC score	0.016219 (rank : 98)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	138	Target Neighborhood Hits	458	Shared Neighborhood Hits	6
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

CN032_HUMAN
NC score	0.015992 (rank : 99)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	138	Target Neighborhood Hits	267	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

SMOO_HUMAN
NC score	0.015018 (rank : 100)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	138	Target Neighborhood Hits	391	Shared Neighborhood Hits	19
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

NCOR2_HUMAN
NC score	0.014970 (rank : 101)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	138	Target Neighborhood Hits	870	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

UBE4B_HUMAN
NC score	0.014899 (rank : 102)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	138	Target Neighborhood Hits	158	Shared Neighborhood Hits	7
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

PRG4_HUMAN
NC score	0.014728 (rank : 103)	θ value	0.813845 (rank : 60)
Query Neighborhood Hits	138	Target Neighborhood Hits	764	Shared Neighborhood Hits	24
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

NPHP4_HUMAN
NC score	0.014450 (rank : 104)	θ value	2.36792 (rank : 79)
Query Neighborhood Hits	138	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	O75161	Gene names	NPHP4, KIAA0673
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

MADCA_HUMAN
NC score	0.013907 (rank : 105)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	138	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

NCOR2_MOUSE
NC score	0.012674 (rank : 106)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	138	Target Neighborhood Hits	790	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

K1802_MOUSE
NC score	0.012189 (rank : 107)	θ value	0.279714 (rank : 52)
Query Neighborhood Hits	138	Target Neighborhood Hits	1596	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

TMM28_HUMAN
NC score	0.011240 (rank : 108)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	138	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O75949	Gene names	TMEM28, TED
Domain Architecture	No domain graphic available
Description	Transmembrane protein 28 (TED protein).

MOD5_HUMAN
NC score	0.010762 (rank : 109)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	138	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

MAGE1_HUMAN
NC score	0.010132 (rank : 110)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	138	Target Neighborhood Hits	1389	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

GA2L1_MOUSE
NC score	0.010104 (rank : 111)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	138	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

NU214_HUMAN
NC score	0.009737 (rank : 112)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	138	Target Neighborhood Hits	657	Shared Neighborhood Hits	21
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

MUC1_MOUSE
NC score	0.009733 (rank : 113)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	138	Target Neighborhood Hits	388	Shared Neighborhood Hits	14
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

NACAM_MOUSE
NC score	0.009536 (rank : 114)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	138	Target Neighborhood Hits	1866	Shared Neighborhood Hits	50
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MINT_HUMAN
NC score	0.009522 (rank : 115)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	138	Target Neighborhood Hits	1291	Shared Neighborhood Hits	29
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CI079_HUMAN
NC score	0.009481 (rank : 116)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	138	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

MAGAA_HUMAN
NC score	0.009319 (rank : 117)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	138	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	P43363	Gene names	MAGEA10, MAGE10
Domain Architecture
Description	Melanoma-associated antigen 10 (MAGE-10 antigen).

UBP42_HUMAN
NC score	0.009289 (rank : 118)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	138	Target Neighborhood Hits	445	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

FMNL_HUMAN
NC score	0.009257 (rank : 119)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	138	Target Neighborhood Hits	529	Shared Neighborhood Hits	19
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GATA2_MOUSE
NC score	0.009111 (rank : 120)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	138	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O09100	Gene names	Gata2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

ORC3_HUMAN
NC score	0.008789 (rank : 121)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	138	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

F100A_HUMAN
NC score	0.008705 (rank : 122)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	138	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TB05, Q71MF6	Gene names	FAM100A
Domain Architecture	No domain graphic available
Description	Protein FAM100A.

LEG3_HUMAN
NC score	0.008669 (rank : 123)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	138	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

ARI1B_HUMAN
NC score	0.008206 (rank : 124)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	138	Target Neighborhood Hits	567	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

HIP1R_MOUSE
NC score	0.008198 (rank : 125)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	138	Target Neighborhood Hits	959	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

GATA2_HUMAN
NC score	0.007988 (rank : 126)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	138	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

MLL2_HUMAN
NC score	0.007635 (rank : 127)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	138	Target Neighborhood Hits	1788	Shared Neighborhood Hits	40
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

BCAR1_HUMAN
NC score	0.007615 (rank : 128)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	138	Target Neighborhood Hits	554	Shared Neighborhood Hits	18
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CD45_MOUSE
NC score	0.007260 (rank : 129)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	138	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

EMIL3_HUMAN
NC score	0.006654 (rank : 130)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	138	Target Neighborhood Hits	249	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NT22, Q76KT4	Gene names	EMILIN3, C20orf130, EMILIN5
Domain Architecture	No domain graphic available
Description	EMILIN-3 precursor (EMILIN-5) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5).

OGFR_HUMAN
NC score	0.006559 (rank : 131)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	138	Target Neighborhood Hits	1582	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

DIRA3_HUMAN
NC score	0.006199 (rank : 132)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	138	Target Neighborhood Hits	241	Shared Neighborhood Hits	7
SwissProt Accessions	O95661	Gene names	DIRAS3, ARHI, NOEY2, RHOI
Domain Architecture
Description	GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI).

BLNK_HUMAN
NC score	0.006173 (rank : 133)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	138	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

HCN4_HUMAN
NC score	0.006133 (rank : 134)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	138	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

TCGAP_MOUSE
NC score	0.005584 (rank : 135)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	138	Target Neighborhood Hits	409	Shared Neighborhood Hits	16
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SMAD5_MOUSE
NC score	0.005239 (rank : 136)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	138	Target Neighborhood Hits	74	Shared Neighborhood Hits	6
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

CIC_MOUSE
NC score	0.004816 (rank : 137)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	138	Target Neighborhood Hits	742	Shared Neighborhood Hits	21
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CSKI1_HUMAN
NC score	0.004211 (rank : 138)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	138	Target Neighborhood Hits	997	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PTPRD_HUMAN
NC score	0.003355 (rank : 139)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	138	Target Neighborhood Hits	485	Shared Neighborhood Hits	4
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

KCNH4_HUMAN
NC score	0.003196 (rank : 140)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	138	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

MYO15_HUMAN
NC score	0.002975 (rank : 141)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	138	Target Neighborhood Hits	671	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MEGF9_MOUSE
NC score	0.002877 (rank : 142)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	138	Target Neighborhood Hits	896	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

LRRK1_HUMAN
NC score	0.002578 (rank : 143)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	138	Target Neighborhood Hits	1237	Shared Neighborhood Hits	23
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PTPRD_MOUSE
NC score	0.001827 (rank : 144)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	138	Target Neighborhood Hits	491	Shared Neighborhood Hits	5
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

KTN1_MOUSE
NC score	0.001815 (rank : 145)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	138	Target Neighborhood Hits	1324	Shared Neighborhood Hits	10
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

PCD20_HUMAN
NC score	0.001067 (rank : 146)	θ value	2.36792 (rank : 80)
Query Neighborhood Hits	138	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N6Y1, Q8NDN4, Q9NRT9	Gene names	PCDH20
Domain Architecture	No domain graphic available
Description	Protocadherin-20 precursor (Protocadherin-13).

LAMC2_MOUSE
NC score	0.000546 (rank : 147)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	138	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

BCL3_MOUSE
NC score	0.000457 (rank : 148)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	138	Target Neighborhood Hits	388	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ANK1_MOUSE
NC score	0.000053 (rank : 149)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	138	Target Neighborhood Hits	430	Shared Neighborhood Hits	7
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

SP5_MOUSE
NC score	-0.000703 (rank : 150)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	138	Target Neighborhood Hits	821	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

SP5_HUMAN
NC score	-0.001135 (rank : 151)	θ value	1.81305 (rank : 76)
Query Neighborhood Hits	138	Target Neighborhood Hits	832	Shared Neighborhood Hits	13
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

NTR2_MOUSE
NC score	-0.001558 (rank : 152)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	138	Target Neighborhood Hits	560	Shared Neighborhood Hits	2
SwissProt Accessions	P70310	Gene names	Ntsr2
Domain Architecture
Description	Neurotensin receptor type 2 (NT-R-2) (Low-affinity levocabastine- sensitive neurotensin receptor) (NTRL).

AAK1_MOUSE
NC score	-0.001805 (rank : 153)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	138	Target Neighborhood Hits	1051	Shared Neighborhood Hits	19
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KAISO_MOUSE
NC score	-0.002277 (rank : 154)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	138	Target Neighborhood Hits	821	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BN78, Q8C226, Q9WTZ7	Gene names	Zbtb33, Kaiso
Domain Architecture	No domain graphic available
Description	Transcriptional regulator Kaiso (Zinc finger and BTB domain-containing protein 33).

TYK2_HUMAN
NC score	-0.003037 (rank : 155)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	138	Target Neighborhood Hits	841	Shared Neighborhood Hits	5
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

GLI3_HUMAN
NC score	-0.003623 (rank : 156)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	138	Target Neighborhood Hits	871	Shared Neighborhood Hits	8
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

MARK1_MOUSE
NC score	-0.004038 (rank : 157)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	138	Target Neighborhood Hits	886	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).