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Network neighborhood for query Sequence : NAL14_HUMAN

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NAL14_HUMAN
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NAL14_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
θ value	0 (rank : 2)	NC score	0.983506 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	43
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP5_HUMAN
θ value	0 (rank : 3)	NC score	0.977508 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	9.13544e-178 (rank : 4)	NC score	0.910126 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	560	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NAL12_HUMAN
θ value	4.53388e-177 (rank : 5)	NC score	0.976793 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL13_HUMAN
θ value	3.36238e-172 (rank : 6)	NC score	0.980319 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP2_HUMAN
θ value	2.49359e-167 (rank : 7)	NC score	0.978480 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

CIAS1_HUMAN
θ value	6.35588e-163 (rank : 8)	NC score	0.974196 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	7.52544e-156 (rank : 9)	NC score	0.974484 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NALP7_HUMAN
θ value	1.42253e-146 (rank : 10)	NC score	0.970727 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
θ value	4.90052e-139 (rank : 11)	NC score	0.964459 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP1_HUMAN
θ value	8.41738e-115 (rank : 12)	NC score	0.923679 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP6_HUMAN
θ value	3.22841e-82 (rank : 13)	NC score	0.932449 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
θ value	4.82422e-78 (rank : 14)	NC score	0.930973 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NAL10_HUMAN
θ value	2.84138e-62 (rank : 15)	NC score	0.890562 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

RINI_MOUSE
θ value	9.1404e-61 (rank : 16)	NC score	0.890233 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

RINI_HUMAN
θ value	8.85319e-56 (rank : 17)	NC score	0.892489 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	37
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

NAL10_MOUSE
θ value	1.08223e-53 (rank : 18)	NC score	0.887971 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	46	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CARD4_HUMAN
θ value	4.28545e-26 (rank : 19)	NC score	0.714100 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	102	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	5.59698e-26 (rank : 20)	NC score	0.715031 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CAR15_HUMAN
θ value	1.24688e-25 (rank : 21)	NC score	0.732827 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	4.01107e-24 (rank : 22)	NC score	0.749751 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

C2TA_MOUSE
θ value	2.98157e-11 (rank : 23)	NC score	0.614188 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	131	Shared Neighborhood Hits	38
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC31_HUMAN
θ value	1.06045e-08 (rank : 24)	NC score	0.529761 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_HUMAN
θ value	5.26297e-08 (rank : 25)	NC score	0.564790 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
θ value	3.41135e-07 (rank : 26)	NC score	0.536974 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

C2TA_HUMAN
θ value	4.45536e-07 (rank : 27)	NC score	0.592622 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_MOUSE
θ value	2.21117e-06 (rank : 28)	NC score	0.525908 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

RGP1_HUMAN
θ value	3.77169e-06 (rank : 29)	NC score	0.375808 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	124	Shared Neighborhood Hits	25
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LRC45_MOUSE
θ value	1.87187e-05 (rank : 30)	NC score	0.183564 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	959	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

RGP1_MOUSE
θ value	7.1131e-05 (rank : 31)	NC score	0.360312 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

BIR1A_MOUSE
θ value	9.29e-05 (rank : 32)	NC score	0.225317 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

MEFV_HUMAN
θ value	9.29e-05 (rank : 33)	NC score	0.086618 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	14
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

BIRC1_HUMAN
θ value	0.00020696 (rank : 34)	NC score	0.242507 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1F_MOUSE
θ value	0.00035302 (rank : 35)	NC score	0.219733 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

LRC45_HUMAN
θ value	0.000461057 (rank : 36)	NC score	0.172972 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	933	Shared Neighborhood Hits	30
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BIR1B_MOUSE
θ value	0.000602161 (rank : 37)	NC score	0.205991 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	0.00134147 (rank : 38)	NC score	0.217456 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
θ value	0.00175202 (rank : 39)	NC score	0.211786 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

LONM_HUMAN
θ value	0.0193708 (rank : 40)	NC score	0.052398 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

FXL16_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.048076 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

MAPE_HUMAN
θ value	0.0563607 (rank : 42)	NC score	0.072320 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

LRRK2_HUMAN
θ value	0.0736092 (rank : 43)	NC score	0.005000 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	1382	Shared Neighborhood Hits	15
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TLR13_MOUSE
θ value	0.125558 (rank : 44)	NC score	0.022058 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

AIM2_HUMAN
θ value	0.163984 (rank : 45)	NC score	0.053943 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

CAR12_HUMAN
θ value	0.21417 (rank : 46)	NC score	0.331270 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CP2A4_MOUSE
θ value	0.279714 (rank : 47)	NC score	0.007555 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	P15392	Gene names	Cyp2a4, Cyp2a-4
Domain Architecture
Description	Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Testosterone 15-alpha- hydroxylase) (P450-15-alpha) (P450-IIA3.1).

CP2A5_MOUSE
θ value	0.279714 (rank : 48)	NC score	0.007533 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P20852	Gene names	Cyp2a5, Cyp2a-5
Domain Architecture
Description	Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (P450-15-COH) (P450-IIA3.2).

FBXL5_HUMAN
θ value	0.47712 (rank : 49)	NC score	0.020857 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKA1, Q8NHP3, Q9NXN2, Q9P0I0, Q9P0X5, Q9UJT7, Q9UKC8	Gene names	FBXL5, FBL4, FBL5, FLR1
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein).

LRC14_HUMAN
θ value	0.62314 (rank : 50)	NC score	0.108135 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	20
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

BMS1_HUMAN
θ value	0.813845 (rank : 51)	NC score	0.027917 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

PHLPL_HUMAN
θ value	1.06291 (rank : 52)	NC score	0.021097 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	310	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PRAM1_HUMAN
θ value	1.06291 (rank : 53)	NC score	0.025958 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

DOCK2_HUMAN
θ value	1.38821 (rank : 54)	NC score	0.011502 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

FXL21_HUMAN
θ value	1.81305 (rank : 55)	NC score	0.012527 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKT6	Gene names	FBXL21, FBL21, FBL3, FBXL3B
Domain Architecture
Description	F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box/LRR-repeat protein 3B) (F-box and leucine-rich repeat protein 3B).

LRC42_MOUSE
θ value	2.36792 (rank : 56)	NC score	0.042354 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R2U7, Q3TE62, Q9CTP9	Gene names	Lrrc42
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 42.

OR5DD_HUMAN
θ value	2.36792 (rank : 57)	NC score	-0.003197 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	690	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NGL4	Gene names	OR5D13
Domain Architecture
Description	Olfactory receptor 5D13.

CACB4_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.008246 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

FXL13_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.037600 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

LRC33_MOUSE
θ value	3.0926 (rank : 60)	NC score	0.018985 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

PRA12_HUMAN
θ value	3.0926 (rank : 61)	NC score	0.044942 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

DOCK2_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.009932 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

LRC33_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.021648 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

PHLPL_MOUSE
θ value	4.03905 (rank : 64)	NC score	0.019041 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

LRC39_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.014197 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	274	Shared Neighborhood Hits	19
SwissProt Accessions	Q96DD0, Q5VVK7	Gene names	LRRC39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39 (Densin hlg).

LRCH3_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.008136 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	257	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

TLR8_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.009729 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	297	Shared Neighborhood Hits	16
SwissProt Accessions	P58682, Q91XI7	Gene names	Tlr8
Domain Architecture
Description	Toll-like receptor 8 precursor.

CD14_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.063674 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	12
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

MOD5_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.010782 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

MYO9B_HUMAN
θ value	6.88961 (rank : 70)	NC score	-0.000519 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	641	Shared Neighborhood Hits	2
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

BAG1_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.007534 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q60739	Gene names	Bag1
Domain Architecture
Description	BAG family molecular chaperone regulator 1 (BCL-2-binding athanogene- 1) (BAG-1).

CACB4_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.006215 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

CCD46_HUMAN
θ value	8.99809 (rank : 73)	NC score	-0.000467 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	1430	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CDKL3_MOUSE
θ value	8.99809 (rank : 74)	NC score	-0.004245 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	857	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KLDC1_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.003766 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YG3	Gene names	Klhdc1
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 1.

LGI3_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.002703 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	229	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

ASC_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.203734 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.258658 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

CARD8_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.119970 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

MEFV_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.143237 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

TMOD2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.052199 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

Hits sorted by NC score

NAL14_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
NC score	0.983506 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	43
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL13_HUMAN
NC score	0.980319 (rank : 3)	θ value	3.36238e-172 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP2_HUMAN
NC score	0.978480 (rank : 4)	θ value	2.49359e-167 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP5_HUMAN
NC score	0.977508 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL12_HUMAN
NC score	0.976793 (rank : 6)	θ value	4.53388e-177 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_MOUSE
NC score	0.974484 (rank : 7)	θ value	7.52544e-156 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

CIAS1_HUMAN
NC score	0.974196 (rank : 8)	θ value	6.35588e-163 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NALP7_HUMAN
NC score	0.970727 (rank : 9)	θ value	1.42253e-146 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
NC score	0.964459 (rank : 10)	θ value	4.90052e-139 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	66	Shared Neighborhood Hits	37
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP6_HUMAN
NC score	0.932449 (rank : 11)	θ value	3.22841e-82 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.930973 (rank : 12)	θ value	4.82422e-78 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP1_HUMAN
NC score	0.923679 (rank : 13)	θ value	8.41738e-115 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP5_MOUSE
NC score	0.910126 (rank : 14)	θ value	9.13544e-178 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	560	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.892489 (rank : 15)	θ value	8.85319e-56 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	78	Shared Neighborhood Hits	37
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

NAL10_HUMAN
NC score	0.890562 (rank : 16)	θ value	2.84138e-62 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	30
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

RINI_MOUSE
NC score	0.890233 (rank : 17)	θ value	9.1404e-61 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

NAL10_MOUSE
NC score	0.887971 (rank : 18)	θ value	1.08223e-53 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	46	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CAR15_MOUSE
NC score	0.749751 (rank : 19)	θ value	4.01107e-24 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.732827 (rank : 20)	θ value	1.24688e-25 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
NC score	0.715031 (rank : 21)	θ value	5.59698e-26 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.714100 (rank : 22)	θ value	4.28545e-26 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	102	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_MOUSE
NC score	0.614188 (rank : 23)	θ value	2.98157e-11 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	131	Shared Neighborhood Hits	38
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.592622 (rank : 24)	θ value	4.45536e-07 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.564790 (rank : 25)	θ value	5.26297e-08 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
NC score	0.536974 (rank : 26)	θ value	3.41135e-07 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC31_HUMAN
NC score	0.529761 (rank : 27)	θ value	1.06045e-08 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_MOUSE
NC score	0.525908 (rank : 28)	θ value	2.21117e-06 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

RGP1_HUMAN
NC score	0.375808 (rank : 29)	θ value	3.77169e-06 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	124	Shared Neighborhood Hits	25
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.360312 (rank : 30)	θ value	7.1131e-05 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

CAR12_HUMAN
NC score	0.331270 (rank : 31)	θ value	0.21417 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

ASC_MOUSE
NC score	0.258658 (rank : 32)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIRC1_HUMAN
NC score	0.242507 (rank : 33)	θ value	0.00020696 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.225317 (rank : 34)	θ value	9.29e-05 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.219733 (rank : 35)	θ value	0.00035302 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	88	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.217456 (rank : 36)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.211786 (rank : 37)	θ value	0.00175202 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.205991 (rank : 38)	θ value	0.000602161 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

ASC_HUMAN
NC score	0.203734 (rank : 39)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

LRC45_MOUSE
NC score	0.183564 (rank : 40)	θ value	1.87187e-05 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	959	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.172972 (rank : 41)	θ value	0.000461057 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	933	Shared Neighborhood Hits	30
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

MEFV_MOUSE
NC score	0.143237 (rank : 42)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	236	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

CARD8_HUMAN
NC score	0.119970 (rank : 43)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

LRC14_HUMAN
NC score	0.108135 (rank : 44)	θ value	0.62314 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	20
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

MEFV_HUMAN
NC score	0.086618 (rank : 45)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	14
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MAPE_HUMAN
NC score	0.072320 (rank : 46)	θ value	0.0563607 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

CD14_MOUSE
NC score	0.063674 (rank : 47)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	12
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

AIM2_HUMAN
NC score	0.053943 (rank : 48)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

LONM_HUMAN
NC score	0.052398 (rank : 49)	θ value	0.0193708 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

TMOD2_HUMAN
NC score	0.052199 (rank : 50)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

FXL16_HUMAN
NC score	0.048076 (rank : 51)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N461, Q2MHR2, Q96S14, Q9UJI0	Gene names	FBXL16, C16orf22, FBL16
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16).

PRA12_HUMAN
NC score	0.044942 (rank : 52)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

LRC42_MOUSE
NC score	0.042354 (rank : 53)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R2U7, Q3TE62, Q9CTP9	Gene names	Lrrc42
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 42.

FXL13_HUMAN
NC score	0.037600 (rank : 54)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

BMS1_HUMAN
NC score	0.027917 (rank : 55)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

PRAM1_HUMAN
NC score	0.025958 (rank : 56)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

TLR13_MOUSE
NC score	0.022058 (rank : 57)	θ value	0.125558 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

LRC33_HUMAN
NC score	0.021648 (rank : 58)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	293	Shared Neighborhood Hits	20
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

PHLPL_HUMAN
NC score	0.021097 (rank : 59)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	310	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

FBXL5_HUMAN
NC score	0.020857 (rank : 60)	θ value	0.47712 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKA1, Q8NHP3, Q9NXN2, Q9P0I0, Q9P0X5, Q9UJT7, Q9UKC8	Gene names	FBXL5, FBL4, FBL5, FLR1
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein).

PHLPL_MOUSE
NC score	0.019041 (rank : 61)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	303	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

LRC33_MOUSE
NC score	0.018985 (rank : 62)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	296	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC39_HUMAN
NC score	0.014197 (rank : 63)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	274	Shared Neighborhood Hits	19
SwissProt Accessions	Q96DD0, Q5VVK7	Gene names	LRRC39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39 (Densin hlg).

FXL21_HUMAN
NC score	0.012527 (rank : 64)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UKT6	Gene names	FBXL21, FBL21, FBL3, FBXL3B
Domain Architecture
Description	F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box/LRR-repeat protein 3B) (F-box and leucine-rich repeat protein 3B).

DOCK2_HUMAN
NC score	0.011502 (rank : 65)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

MOD5_HUMAN
NC score	0.010782 (rank : 66)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3H1, Q6IAC9, Q96FJ3, Q96L45, Q9NXT7	Gene names	TRIT1, IPT, MOD5
Domain Architecture
Description	tRNA isopentenyltransferase, mitochondrial precursor (EC 2.5.1.8) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPTase) (IPPT) (hGRO1).

DOCK2_MOUSE
NC score	0.009932 (rank : 67)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

TLR8_MOUSE
NC score	0.009729 (rank : 68)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	297	Shared Neighborhood Hits	16
SwissProt Accessions	P58682, Q91XI7	Gene names	Tlr8
Domain Architecture
Description	Toll-like receptor 8 precursor.

CACB4_MOUSE
NC score	0.008246 (rank : 69)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0S4, Q8BRN6, Q8CAJ9	Gene names	Cacnb4, Cacnlb4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

LRCH3_MOUSE
NC score	0.008136 (rank : 70)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	257	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BVU0, Q3U222, Q3UZ74	Gene names	Lrch3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 3 precursor.

CP2A4_MOUSE
NC score	0.007555 (rank : 71)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	P15392	Gene names	Cyp2a4, Cyp2a-4
Domain Architecture
Description	Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Testosterone 15-alpha- hydroxylase) (P450-15-alpha) (P450-IIA3.1).

BAG1_MOUSE
NC score	0.007534 (rank : 72)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q60739	Gene names	Bag1
Domain Architecture
Description	BAG family molecular chaperone regulator 1 (BCL-2-binding athanogene- 1) (BAG-1).

CP2A5_MOUSE
NC score	0.007533 (rank : 73)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	P20852	Gene names	Cyp2a5, Cyp2a-5
Domain Architecture
Description	Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (P450-15-COH) (P450-IIA3.2).

CACB4_HUMAN
NC score	0.006215 (rank : 74)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	O00305, O60515, Q96L40	Gene names	CACNB4, CACNLB4
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-4 (CAB4) (Calcium channel voltage-dependent subunit beta 4).

LRRK2_HUMAN
NC score	0.005000 (rank : 75)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	1382	Shared Neighborhood Hits	15
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

KLDC1_MOUSE
NC score	0.003766 (rank : 76)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YG3	Gene names	Klhdc1
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 1.

LGI3_MOUSE
NC score	0.002703 (rank : 77)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	229	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

CCD46_HUMAN
NC score	-0.000467 (rank : 78)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	1430	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

MYO9B_HUMAN
NC score	-0.000519 (rank : 79)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	641	Shared Neighborhood Hits	2
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

OR5DD_HUMAN
NC score	-0.003197 (rank : 80)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	690	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NGL4	Gene names	OR5D13
Domain Architecture
Description	Olfactory receptor 5D13.

CDKL3_MOUSE
NC score	-0.004245 (rank : 81)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	857	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).