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Network neighborhood for query Sequence : NALP5_HUMAN

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NALP5_HUMAN
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NAL14_HUMAN
θ value	0 (rank : 1)	NC score	0.977508 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	48
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP5_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP5_MOUSE
θ value	0 (rank : 3)	NC score	0.924537 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	560	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NAL13_HUMAN
θ value	1.09426e-130 (rank : 4)	NC score	0.964601 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	44
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL12_HUMAN
θ value	1.86652e-130 (rank : 5)	NC score	0.960895 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NALP4_HUMAN
θ value	4.5974e-129 (rank : 6)	NC score	0.965515 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
θ value	4.30305e-127 (rank : 7)	NC score	0.961732 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	65	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

CIAS1_MOUSE
θ value	2.44341e-122 (rank : 8)	NC score	0.960073 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

CIAS1_HUMAN
θ value	4.16784e-122 (rank : 9)	NC score	0.958051 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NALP7_HUMAN
θ value	2.37764e-101 (rank : 10)	NC score	0.950418 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
θ value	7.15887e-98 (rank : 11)	NC score	0.956804 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP1_HUMAN
θ value	5.50685e-82 (rank : 12)	NC score	0.903474 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	138	Shared Neighborhood Hits	46
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

RINI_MOUSE
θ value	1.15359e-63 (rank : 13)	NC score	0.902914 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	87	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

NALP6_MOUSE
θ value	2.17557e-62 (rank : 14)	NC score	0.908555 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP6_HUMAN
θ value	2.65945e-60 (rank : 15)	NC score	0.909460 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

RINI_HUMAN
θ value	8.55514e-59 (rank : 16)	NC score	0.902444 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	78	Shared Neighborhood Hits	40
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

NAL10_HUMAN
θ value	3.26607e-42 (rank : 17)	NC score	0.857869 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	5.77852e-31 (rank : 18)	NC score	0.848272 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CARD4_MOUSE
θ value	2.06002e-20 (rank : 19)	NC score	0.695862 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
θ value	1.47631e-18 (rank : 20)	NC score	0.693637 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	102	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CAR15_HUMAN
θ value	1.38178e-16 (rank : 21)	NC score	0.699622 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	77	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	4.02038e-16 (rank : 22)	NC score	0.715037 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

C2TA_HUMAN
θ value	2.69671e-12 (rank : 23)	NC score	0.582852 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
θ value	4.0297e-08 (rank : 24)	NC score	0.559115 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
θ value	5.81887e-07 (rank : 25)	NC score	0.519704 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	139	Shared Neighborhood Hits	49
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC45_HUMAN
θ value	9.92553e-07 (rank : 26)	NC score	0.180892 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	933	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CF154_HUMAN
θ value	2.88788e-06 (rank : 27)	NC score	0.548693 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC45_MOUSE
θ value	1.09739e-05 (rank : 28)	NC score	0.191109 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	959	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

RGP1_MOUSE
θ value	2.44474e-05 (rank : 29)	NC score	0.361468 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	105	Shared Neighborhood Hits	28
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LRC34_MOUSE
θ value	0.000158464 (rank : 30)	NC score	0.520988 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

RGP1_HUMAN
θ value	0.000158464 (rank : 31)	NC score	0.376609 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

C2TA_MOUSE
θ value	0.000461057 (rank : 32)	NC score	0.586439 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CAR12_HUMAN
θ value	0.00175202 (rank : 33)	NC score	0.296866 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

MEFV_MOUSE
θ value	0.00665767 (rank : 34)	NC score	0.152588 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

MAPE_HUMAN
θ value	0.0113563 (rank : 35)	NC score	0.119952 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	24	Shared Neighborhood Hits	19
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

PRA12_HUMAN
θ value	0.0113563 (rank : 36)	NC score	0.094622 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

MEFV_HUMAN
θ value	0.0148317 (rank : 37)	NC score	0.085553 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

THAP4_MOUSE
θ value	0.0330416 (rank : 38)	NC score	0.032884 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	130	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

PRAM4_HUMAN
θ value	0.0431538 (rank : 39)	NC score	0.085560 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	O60810, Q5LJB5	Gene names	PRAMEF4
Domain Architecture	No domain graphic available
Description	PRAME family member 4.

PRAM5_HUMAN
θ value	0.0431538 (rank : 40)	NC score	0.088148 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TYX0	Gene names	PRAMEF5
Domain Architecture	No domain graphic available
Description	PRAME family member 5.

PRAM6_HUMAN
θ value	0.0431538 (rank : 41)	NC score	0.088155 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VXH4	Gene names	PRAMEF6
Domain Architecture	No domain graphic available
Description	PRAME family member 6.

PRAM9_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.084616 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWM5	Gene names	PRAMEF9
Domain Architecture	No domain graphic available
Description	PRAME family member 9.

TBCEL_HUMAN
θ value	0.0736092 (rank : 43)	NC score	0.054500 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q5QJ74	Gene names	LRRC35
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35).

FXL13_HUMAN
θ value	0.163984 (rank : 44)	NC score	0.047327 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

BIRC1_HUMAN
θ value	0.279714 (rank : 45)	NC score	0.176138 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

CD14_MOUSE
θ value	0.279714 (rank : 46)	NC score	0.074814 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

PRAM7_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.081981 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VXH5	Gene names	PRAMEF7
Domain Architecture	No domain graphic available
Description	PRAME family member 7.

PRAM8_HUMAN
θ value	0.279714 (rank : 48)	NC score	0.083701 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VWM4	Gene names	PRAMEF8
Domain Architecture	No domain graphic available
Description	PRAME family member 8.

CK5P2_HUMAN
θ value	0.813845 (rank : 49)	NC score	0.006267 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	1433	Shared Neighborhood Hits	10
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

FXL14_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.043725 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.043606 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

TBCEL_MOUSE
θ value	1.06291 (rank : 52)	NC score	0.038284 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5W3, Q8C7A5	Gene names	Lrrc35
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35).

TITIN_HUMAN
θ value	1.06291 (rank : 53)	NC score	-0.001640 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	2923	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

OBSCN_HUMAN
θ value	2.36792 (rank : 54)	NC score	-0.002303 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	1931	Shared Neighborhood Hits	8
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

LRC14_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.145115 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	57	Shared Neighborhood Hits	27
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

BRCA2_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.009687 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	P97929, O35922, P97383	Gene names	Brca2, Fancd1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog).

FLII_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.015323 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	304	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJ28, Q8K095, Q8VI44	Gene names	Flii, Fli1, Fliih
Domain Architecture	No domain graphic available
Description	Protein flightless-1 homolog.

GON4L_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.011924 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

LRC8D_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.017575 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	282	Shared Neighborhood Hits	18
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

AKA12_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.020550 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	825	Shared Neighborhood Hits	11
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CDY2_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.007829 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

FBXL7_HUMAN
θ value	5.27518 (rank : 62)	NC score	0.021225 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UJT9, O94926	Gene names	FBXL7, FBL6, FBL7, KIAA0840
Domain Architecture
Description	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7).

LRC46_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.008734 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	181	Shared Neighborhood Hits	8
SwissProt Accessions	Q96FV0	Gene names	LRRC46
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 46.

PHLPL_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.016542 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

BIR1A_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.158046 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	94	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.139293 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.151173 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.152371 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

CDY1_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.007251 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

CPN2_MOUSE
θ value	6.88961 (rank : 70)	NC score	0.008277 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

FLII_HUMAN
θ value	6.88961 (rank : 71)	NC score	0.011916 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	318	Shared Neighborhood Hits	21
SwissProt Accessions	Q13045	Gene names	FLII, FLIL
Domain Architecture
Description	Protein flightless-1 homolog.

KCT2_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.017543 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

KIME_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.009463 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q03426	Gene names	MVK
Domain Architecture
Description	Mevalonate kinase (EC 2.7.1.36) (MK).

KSR1_HUMAN
θ value	6.88961 (rank : 74)	NC score	-0.002269 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	867	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

LAD1_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.006592 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	391	Shared Neighborhood Hits	6
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PHLPL_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.014993 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

RAD_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.001201 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	P55042, Q96F39	Gene names	RRAD, RAD
Domain Architecture
Description	GTP-binding protein RAD (RAS associated with diabetes) (RAD1).

STK10_MOUSE
θ value	6.88961 (rank : 78)	NC score	-0.003767 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	2132	Shared Neighborhood Hits	12
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TDRD1_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.006783 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MV1	Gene names	Tdrd1
Domain Architecture
Description	Tudor domain-containing protein 1.

BIR1G_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.144401 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

CO3_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.003326 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

PI51C_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.003517 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PRAM2_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.067426 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	O60811	Gene names	PRAMEF2
Domain Architecture	No domain graphic available
Description	PRAME family member 2.

REM2_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.000855 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEL9, Q8BPB1	Gene names	Rem2
Domain Architecture	No domain graphic available
Description	GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2).

TAIP2_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.007402 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	P59055	Gene names	Taip2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

TLR13_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.015668 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

TMOD3_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.045701 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TP53B_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.007381 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	644	Shared Neighborhood Hits	11
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ASC_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.196834 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

ASC_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.249063 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

CARD8_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.114955 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

PRAM1_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.065559 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

PRAM3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.071466 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

TMOD2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.050107 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

Hits sorted by NC score

NALP5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NAL14_HUMAN
NC score	0.977508 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	48
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
NC score	0.965515 (rank : 3)	θ value	4.5974e-129 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL13_HUMAN
NC score	0.964601 (rank : 4)	θ value	1.09426e-130 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	44
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP2_HUMAN
NC score	0.961732 (rank : 5)	θ value	4.30305e-127 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	65	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL12_HUMAN
NC score	0.960895 (rank : 6)	θ value	1.86652e-130 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_MOUSE
NC score	0.960073 (rank : 7)	θ value	2.44341e-122 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	67	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

CIAS1_HUMAN
NC score	0.958051 (rank : 8)	θ value	4.16784e-122 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL11_HUMAN
NC score	0.956804 (rank : 9)	θ value	7.15887e-98 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP7_HUMAN
NC score	0.950418 (rank : 10)	θ value	2.37764e-101 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	65	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP5_MOUSE
NC score	0.924537 (rank : 11)	θ value	0 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	560	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP6_HUMAN
NC score	0.909460 (rank : 12)	θ value	2.65945e-60 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	52	Shared Neighborhood Hits	36
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.908555 (rank : 13)	θ value	2.17557e-62 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP1_HUMAN
NC score	0.903474 (rank : 14)	θ value	5.50685e-82 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	138	Shared Neighborhood Hits	46
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

RINI_MOUSE
NC score	0.902914 (rank : 15)	θ value	1.15359e-63 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	87	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

RINI_HUMAN
NC score	0.902444 (rank : 16)	θ value	8.55514e-59 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	78	Shared Neighborhood Hits	40
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

NAL10_HUMAN
NC score	0.857869 (rank : 17)	θ value	3.26607e-42 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.848272 (rank : 18)	θ value	5.77852e-31 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CAR15_MOUSE
NC score	0.715037 (rank : 19)	θ value	4.02038e-16 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.699622 (rank : 20)	θ value	1.38178e-16 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	77	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
NC score	0.695862 (rank : 21)	θ value	2.06002e-20 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

CARD4_HUMAN
NC score	0.693637 (rank : 22)	θ value	1.47631e-18 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	102	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

C2TA_MOUSE
NC score	0.586439 (rank : 23)	θ value	0.000461057 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.582852 (rank : 24)	θ value	2.69671e-12 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	190	Shared Neighborhood Hits	37
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.559115 (rank : 25)	θ value	4.0297e-08 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
NC score	0.548693 (rank : 26)	θ value	2.88788e-06 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC34_MOUSE
NC score	0.520988 (rank : 27)	θ value	0.000158464 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.519704 (rank : 28)	θ value	5.81887e-07 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	139	Shared Neighborhood Hits	49
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

RGP1_HUMAN
NC score	0.376609 (rank : 29)	θ value	0.000158464 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.361468 (rank : 30)	θ value	2.44474e-05 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	105	Shared Neighborhood Hits	28
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

CAR12_HUMAN
NC score	0.296866 (rank : 31)	θ value	0.00175202 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

ASC_MOUSE
NC score	0.249063 (rank : 32)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

ASC_HUMAN
NC score	0.196834 (rank : 33)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

LRC45_MOUSE
NC score	0.191109 (rank : 34)	θ value	1.09739e-05 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	959	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.180892 (rank : 35)	θ value	9.92553e-07 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	933	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BIRC1_HUMAN
NC score	0.176138 (rank : 36)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.158046 (rank : 37)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	94	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

MEFV_MOUSE
NC score	0.152588 (rank : 38)	θ value	0.00665767 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	236	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

BIR1F_MOUSE
NC score	0.152371 (rank : 39)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.151173 (rank : 40)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

LRC14_HUMAN
NC score	0.145115 (rank : 41)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	57	Shared Neighborhood Hits	27
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

BIR1G_MOUSE
NC score	0.144401 (rank : 42)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.139293 (rank : 43)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

MAPE_HUMAN
NC score	0.119952 (rank : 44)	θ value	0.0113563 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	24	Shared Neighborhood Hits	19
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

CARD8_HUMAN
NC score	0.114955 (rank : 45)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

PRA12_HUMAN
NC score	0.094622 (rank : 46)	θ value	0.0113563 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	O95522	Gene names
Domain Architecture	No domain graphic available
Description	PRAME family member DJ1198H6.2.

PRAM6_HUMAN
NC score	0.088155 (rank : 47)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VXH4	Gene names	PRAMEF6
Domain Architecture	No domain graphic available
Description	PRAME family member 6.

PRAM5_HUMAN
NC score	0.088148 (rank : 48)	θ value	0.0431538 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TYX0	Gene names	PRAMEF5
Domain Architecture	No domain graphic available
Description	PRAME family member 5.

PRAM4_HUMAN
NC score	0.085560 (rank : 49)	θ value	0.0431538 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	O60810, Q5LJB5	Gene names	PRAMEF4
Domain Architecture	No domain graphic available
Description	PRAME family member 4.

MEFV_HUMAN
NC score	0.085553 (rank : 50)	θ value	0.0148317 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

PRAM9_HUMAN
NC score	0.084616 (rank : 51)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VWM5	Gene names	PRAMEF9
Domain Architecture	No domain graphic available
Description	PRAME family member 9.

PRAM8_HUMAN
NC score	0.083701 (rank : 52)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VWM4	Gene names	PRAMEF8
Domain Architecture	No domain graphic available
Description	PRAME family member 8.

PRAM7_HUMAN
NC score	0.081981 (rank : 53)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q5VXH5	Gene names	PRAMEF7
Domain Architecture	No domain graphic available
Description	PRAME family member 7.

CD14_MOUSE
NC score	0.074814 (rank : 54)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	104	Shared Neighborhood Hits	10
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

PRAM3_HUMAN
NC score	0.071466 (rank : 55)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	23	Shared Neighborhood Hits	13
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

PRAM2_HUMAN
NC score	0.067426 (rank : 56)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	O60811	Gene names	PRAMEF2
Domain Architecture	No domain graphic available
Description	PRAME family member 2.

PRAM1_HUMAN
NC score	0.065559 (rank : 57)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	O95521, Q9UQP2	Gene names	PRAMEF1
Domain Architecture	No domain graphic available
Description	PRAME family member 1.

TBCEL_HUMAN
NC score	0.054500 (rank : 58)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q5QJ74	Gene names	LRRC35
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35).

TMOD2_HUMAN
NC score	0.050107 (rank : 59)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

FXL13_HUMAN
NC score	0.047327 (rank : 60)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

TMOD3_MOUSE
NC score	0.045701 (rank : 61)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

FXL14_HUMAN
NC score	0.043725 (rank : 62)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_MOUSE
NC score	0.043606 (rank : 63)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

TBCEL_MOUSE
NC score	0.038284 (rank : 64)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C5W3, Q8C7A5	Gene names	Lrrc35
Domain Architecture	No domain graphic available
Description	Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35).

THAP4_MOUSE
NC score	0.032884 (rank : 65)	θ value	0.0330416 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	130	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P3Z3, Q3US28, Q6NZN6, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3	Gene names	Thap4
Domain Architecture	No domain graphic available
Description	THAP domain-containing protein 4.

FBXL7_HUMAN
NC score	0.021225 (rank : 66)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UJT9, O94926	Gene names	FBXL7, FBL6, FBL7, KIAA0840
Domain Architecture
Description	F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7).

AKA12_HUMAN
NC score	0.020550 (rank : 67)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	825	Shared Neighborhood Hits	11
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

LRC8D_HUMAN
NC score	0.017575 (rank : 68)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	282	Shared Neighborhood Hits	18
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

KCT2_MOUSE
NC score	0.017543 (rank : 69)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

PHLPL_HUMAN
NC score	0.016542 (rank : 70)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

TLR13_MOUSE
NC score	0.015668 (rank : 71)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	335	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

FLII_MOUSE
NC score	0.015323 (rank : 72)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	304	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJ28, Q8K095, Q8VI44	Gene names	Flii, Fli1, Fliih
Domain Architecture	No domain graphic available
Description	Protein flightless-1 homolog.

PHLPL_MOUSE
NC score	0.014993 (rank : 73)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	303	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

GON4L_MOUSE
NC score	0.011924 (rank : 74)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

FLII_HUMAN
NC score	0.011916 (rank : 75)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	318	Shared Neighborhood Hits	21
SwissProt Accessions	Q13045	Gene names	FLII, FLIL
Domain Architecture
Description	Protein flightless-1 homolog.

BRCA2_MOUSE
NC score	0.009687 (rank : 76)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	P97929, O35922, P97383	Gene names	Brca2, Fancd1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog).

KIME_HUMAN
NC score	0.009463 (rank : 77)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q03426	Gene names	MVK
Domain Architecture
Description	Mevalonate kinase (EC 2.7.1.36) (MK).

LRC46_HUMAN
NC score	0.008734 (rank : 78)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	181	Shared Neighborhood Hits	8
SwissProt Accessions	Q96FV0	Gene names	LRRC46
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 46.

CPN2_MOUSE
NC score	0.008277 (rank : 79)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CDY2_HUMAN
NC score	0.007829 (rank : 80)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F7	Gene names	CDY2A, CDY2
Domain Architecture
Description	Testis-specific chromodomain protein Y 2.

TAIP2_MOUSE
NC score	0.007402 (rank : 81)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	P59055	Gene names	Taip2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

TP53B_MOUSE
NC score	0.007381 (rank : 82)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	644	Shared Neighborhood Hits	11
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

CDY1_HUMAN
NC score	0.007251 (rank : 83)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6F8, O14600	Gene names	CDY1
Domain Architecture
Description	Testis-specific chromodomain protein Y 1.

TDRD1_MOUSE
NC score	0.006783 (rank : 84)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	37	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MV1	Gene names	Tdrd1
Domain Architecture
Description	Tudor domain-containing protein 1.

LAD1_MOUSE
NC score	0.006592 (rank : 85)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	391	Shared Neighborhood Hits	6
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

CK5P2_HUMAN
NC score	0.006267 (rank : 86)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	1433	Shared Neighborhood Hits	10
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

PI51C_HUMAN
NC score	0.003517 (rank : 87)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

CO3_HUMAN
NC score	0.003326 (rank : 88)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P01024	Gene names	C3
Domain Architecture
Description	Complement C3 precursor [Contains: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c fragment; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment].

RAD_HUMAN
NC score	0.001201 (rank : 89)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	224	Shared Neighborhood Hits	3
SwissProt Accessions	P55042, Q96F39	Gene names	RRAD, RAD
Domain Architecture
Description	GTP-binding protein RAD (RAS associated with diabetes) (RAD1).

REM2_MOUSE
NC score	0.000855 (rank : 90)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEL9, Q8BPB1	Gene names	Rem2
Domain Architecture	No domain graphic available
Description	GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2).

TITIN_HUMAN
NC score	-0.001640 (rank : 91)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	2923	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

KSR1_HUMAN
NC score	-0.002269 (rank : 92)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	867	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

OBSCN_HUMAN
NC score	-0.002303 (rank : 93)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	1931	Shared Neighborhood Hits	8
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

STK10_MOUSE
NC score	-0.003767 (rank : 94)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	2132	Shared Neighborhood Hits	12
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).