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Network neighborhood for query Sequence : CIAS1_MOUSE

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CIAS1_MOUSE
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CIAS1_HUMAN
θ value	0 (rank : 1)	NC score	0.996781 (rank : 2)
Query Neighborhood Hits	67	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	67	Target Neighborhood Hits	67	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL12_HUMAN
θ value	0 (rank : 3)	NC score	0.987031 (rank : 3)
Query Neighborhood Hits	67	Target Neighborhood Hits	96	Shared Neighborhood Hits	52
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL14_HUMAN
θ value	7.52544e-156 (rank : 4)	NC score	0.974484 (rank : 4)
Query Neighborhood Hits	67	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
θ value	1.6882e-131 (rank : 5)	NC score	0.971850 (rank : 5)
Query Neighborhood Hits	67	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
θ value	2.69525e-129 (rank : 6)	NC score	0.965911 (rank : 6)
Query Neighborhood Hits	67	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL13_HUMAN
θ value	3.29472e-127 (rank : 7)	NC score	0.963289 (rank : 7)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_HUMAN
θ value	2.44341e-122 (rank : 8)	NC score	0.960073 (rank : 8)
Query Neighborhood Hits	67	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP1_HUMAN
θ value	3.65119e-118 (rank : 9)	NC score	0.924306 (rank : 13)
Query Neighborhood Hits	67	Target Neighborhood Hits	138	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP5_MOUSE
θ value	1.75513e-112 (rank : 10)	NC score	0.891323 (rank : 16)
Query Neighborhood Hits	67	Target Neighborhood Hits	560	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP7_HUMAN
θ value	2.6227e-108 (rank : 11)	NC score	0.959536 (rank : 9)
Query Neighborhood Hits	67	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NALP6_HUMAN
θ value	9.65309e-103 (rank : 12)	NC score	0.949456 (rank : 11)
Query Neighborhood Hits	67	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
θ value	1.44246e-98 (rank : 13)	NC score	0.947681 (rank : 12)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NAL11_HUMAN
θ value	7.91507e-97 (rank : 14)	NC score	0.949820 (rank : 10)
Query Neighborhood Hits	67	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NAL10_HUMAN
θ value	3.93732e-88 (rank : 15)	NC score	0.917871 (rank : 14)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	6.30065e-78 (rank : 16)	NC score	0.910694 (rank : 15)
Query Neighborhood Hits	67	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RINI_HUMAN
θ value	1.78386e-56 (rank : 17)	NC score	0.878050 (rank : 17)
Query Neighborhood Hits	67	Target Neighborhood Hits	78	Shared Neighborhood Hits	35
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	1.78386e-56 (rank : 18)	NC score	0.873103 (rank : 18)
Query Neighborhood Hits	67	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
θ value	1.6813e-30 (rank : 19)	NC score	0.754446 (rank : 19)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
θ value	7.06379e-29 (rank : 20)	NC score	0.740722 (rank : 20)
Query Neighborhood Hits	67	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_HUMAN
θ value	4.01107e-24 (rank : 21)	NC score	0.716087 (rank : 21)
Query Neighborhood Hits	67	Target Neighborhood Hits	102	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
θ value	1.42661e-21 (rank : 22)	NC score	0.714687 (rank : 22)
Query Neighborhood Hits	67	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
θ value	1.16975e-15 (rank : 23)	NC score	0.642680 (rank : 23)
Query Neighborhood Hits	67	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
θ value	3.52202e-12 (rank : 24)	NC score	0.618717 (rank : 24)
Query Neighborhood Hits	67	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
θ value	2.13673e-09 (rank : 25)	NC score	0.553834 (rank : 25)
Query Neighborhood Hits	67	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

MEFV_MOUSE
θ value	5.26297e-08 (rank : 26)	NC score	0.194135 (rank : 36)
Query Neighborhood Hits	67	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

LRC31_HUMAN
θ value	1.53129e-07 (rank : 27)	NC score	0.501022 (rank : 27)
Query Neighborhood Hits	67	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_MOUSE
θ value	1.53129e-07 (rank : 28)	NC score	0.519022 (rank : 26)
Query Neighborhood Hits	67	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

RGP1_HUMAN
θ value	2.61198e-07 (rank : 29)	NC score	0.383626 (rank : 29)
Query Neighborhood Hits	67	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

MEFV_HUMAN
θ value	4.92598e-06 (rank : 30)	NC score	0.105037 (rank : 44)
Query Neighborhood Hits	67	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

BIRC1_HUMAN
θ value	3.19293e-05 (rank : 31)	NC score	0.215998 (rank : 34)
Query Neighborhood Hits	67	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

RGP1_MOUSE
θ value	5.44631e-05 (rank : 32)	NC score	0.364729 (rank : 30)
Query Neighborhood Hits	67	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

CF154_HUMAN
θ value	0.00509761 (rank : 33)	NC score	0.493261 (rank : 28)
Query Neighborhood Hits	67	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRC45_MOUSE
θ value	0.00869519 (rank : 34)	NC score	0.171035 (rank : 41)
Query Neighborhood Hits	67	Target Neighborhood Hits	959	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CAR12_HUMAN
θ value	0.0252991 (rank : 35)	NC score	0.310799 (rank : 32)
Query Neighborhood Hits	67	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

ASC_HUMAN
θ value	0.0330416 (rank : 36)	NC score	0.265575 (rank : 33)
Query Neighborhood Hits	67	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIR1A_MOUSE
θ value	0.0330416 (rank : 37)	NC score	0.196961 (rank : 35)
Query Neighborhood Hits	67	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

ASC_MOUSE
θ value	0.0563607 (rank : 38)	NC score	0.319202 (rank : 31)
Query Neighborhood Hits	67	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIR1E_MOUSE
θ value	0.125558 (rank : 39)	NC score	0.187661 (rank : 38)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

PHLPP_MOUSE
θ value	0.163984 (rank : 40)	NC score	0.041815 (rank : 49)
Query Neighborhood Hits	67	Target Neighborhood Hits	394	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

LRC45_HUMAN
θ value	0.21417 (rank : 41)	NC score	0.160946 (rank : 42)
Query Neighborhood Hits	67	Target Neighborhood Hits	933	Shared Neighborhood Hits	33
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BIR1B_MOUSE
θ value	0.365318 (rank : 42)	NC score	0.175931 (rank : 40)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

PHLPL_HUMAN
θ value	0.365318 (rank : 43)	NC score	0.031007 (rank : 51)
Query Neighborhood Hits	67	Target Neighborhood Hits	310	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

BIR1F_MOUSE
θ value	0.62314 (rank : 44)	NC score	0.188429 (rank : 37)
Query Neighborhood Hits	67	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

LAP4_MOUSE
θ value	0.62314 (rank : 45)	NC score	0.017516 (rank : 57)
Query Neighborhood Hits	67	Target Neighborhood Hits	590	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LRC15_MOUSE
θ value	0.62314 (rank : 46)	NC score	0.020243 (rank : 55)
Query Neighborhood Hits	67	Target Neighborhood Hits	305	Shared Neighborhood Hits	23
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

PHLPP_HUMAN
θ value	0.62314 (rank : 47)	NC score	0.038819 (rank : 50)
Query Neighborhood Hits	67	Target Neighborhood Hits	604	Shared Neighborhood Hits	20
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

ABTAP_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.023300 (rank : 53)
Query Neighborhood Hits	67	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

LRC42_MOUSE
θ value	1.81305 (rank : 49)	NC score	0.043175 (rank : 48)
Query Neighborhood Hits	67	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R2U7, Q3TE62, Q9CTP9	Gene names	Lrrc42
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 42.

PDZK4_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.013687 (rank : 59)
Query Neighborhood Hits	67	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.013828 (rank : 58)
Query Neighborhood Hits	67	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

BIR1G_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.180433 (rank : 39)
Query Neighborhood Hits	67	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

CPN2_MOUSE
θ value	2.36792 (rank : 53)	NC score	0.012720 (rank : 62)
Query Neighborhood Hits	67	Target Neighborhood Hits	291	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

PHLPL_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.028760 (rank : 52)
Query Neighborhood Hits	67	Target Neighborhood Hits	303	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PIDD_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.019035 (rank : 56)
Query Neighborhood Hits	67	Target Neighborhood Hits	271	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

TMOD2_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.054691 (rank : 47)
Query Neighborhood Hits	67	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

FBX31_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.013027 (rank : 61)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

HMMR_MOUSE
θ value	5.27518 (rank : 58)	NC score	-0.000537 (rank : 69)
Query Neighborhood Hits	67	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

LAP4_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.013429 (rank : 60)
Query Neighborhood Hits	67	Target Neighborhood Hits	608	Shared Neighborhood Hits	16
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

CCD39_MOUSE
θ value	6.88961 (rank : 60)	NC score	-0.000593 (rank : 70)
Query Neighborhood Hits	67	Target Neighborhood Hits	1026	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

GP1BA_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.021712 (rank : 54)
Query Neighborhood Hits	67	Target Neighborhood Hits	407	Shared Neighborhood Hits	16
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

ZYGBL_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.011279 (rank : 64)
Query Neighborhood Hits	67	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z7L7, O00156, Q5T272, Q5T273	Gene names	ZYG11BL, C9orf60, ZYG
Domain Architecture	No domain graphic available
Description	Zyg-11 protein homolog (Zyg-11 homolog B-like).

ZYGBL_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.011328 (rank : 63)
Query Neighborhood Hits	67	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q80ZJ6, Q6PGH5, Q8BG38	Gene names	Zyg11bl, Zyg
Domain Architecture	No domain graphic available
Description	Zyg-11 protein homolog (Zyg-11 homolog B-like).

EMR1_HUMAN
θ value	8.99809 (rank : 64)	NC score	-0.000312 (rank : 68)
Query Neighborhood Hits	67	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

K0372_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.005370 (rank : 65)
Query Neighborhood Hits	67	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

NMDE3_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.002775 (rank : 67)
Query Neighborhood Hits	67	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q14957	Gene names	GRIN2C
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMDE3_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.002786 (rank : 66)
Query Neighborhood Hits	67	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

CARD8_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.123527 (rank : 43)
Query Neighborhood Hits	67	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

CD14_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.055171 (rank : 46)
Query Neighborhood Hits	67	Target Neighborhood Hits	104	Shared Neighborhood Hits	11
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

LRC14_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.083419 (rank : 45)
Query Neighborhood Hits	67	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

Hits sorted by NC score

CIAS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	67	Target Neighborhood Hits	67	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

CIAS1_HUMAN
NC score	0.996781 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	67	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

NAL12_HUMAN
NC score	0.987031 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	67	Target Neighborhood Hits	96	Shared Neighborhood Hits	52
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL14_HUMAN
NC score	0.974484 (rank : 4)	θ value	7.52544e-156 (rank : 4)
Query Neighborhood Hits	67	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
NC score	0.971850 (rank : 5)	θ value	1.6882e-131 (rank : 5)
Query Neighborhood Hits	67	Target Neighborhood Hits	81	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
NC score	0.965911 (rank : 6)	θ value	2.69525e-129 (rank : 6)
Query Neighborhood Hits	67	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL13_HUMAN
NC score	0.963289 (rank : 7)	θ value	3.29472e-127 (rank : 7)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_HUMAN
NC score	0.960073 (rank : 8)	θ value	2.44341e-122 (rank : 8)
Query Neighborhood Hits	67	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP7_HUMAN
NC score	0.959536 (rank : 9)	θ value	2.6227e-108 (rank : 11)
Query Neighborhood Hits	67	Target Neighborhood Hits	65	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
NC score	0.949820 (rank : 10)	θ value	7.91507e-97 (rank : 14)
Query Neighborhood Hits	67	Target Neighborhood Hits	66	Shared Neighborhood Hits	36
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP6_HUMAN
NC score	0.949456 (rank : 11)	θ value	9.65309e-103 (rank : 12)
Query Neighborhood Hits	67	Target Neighborhood Hits	52	Shared Neighborhood Hits	37
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.947681 (rank : 12)	θ value	1.44246e-98 (rank : 13)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP1_HUMAN
NC score	0.924306 (rank : 13)	θ value	3.65119e-118 (rank : 9)
Query Neighborhood Hits	67	Target Neighborhood Hits	138	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL10_HUMAN
NC score	0.917871 (rank : 14)	θ value	3.93732e-88 (rank : 15)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.910694 (rank : 15)	θ value	6.30065e-78 (rank : 16)
Query Neighborhood Hits	67	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NALP5_MOUSE
NC score	0.891323 (rank : 16)	θ value	1.75513e-112 (rank : 10)
Query Neighborhood Hits	67	Target Neighborhood Hits	560	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.878050 (rank : 17)	θ value	1.78386e-56 (rank : 17)
Query Neighborhood Hits	67	Target Neighborhood Hits	78	Shared Neighborhood Hits	35
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.873103 (rank : 18)	θ value	1.78386e-56 (rank : 18)
Query Neighborhood Hits	67	Target Neighborhood Hits	87	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
NC score	0.754446 (rank : 19)	θ value	1.6813e-30 (rank : 19)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.740722 (rank : 20)	θ value	7.06379e-29 (rank : 20)
Query Neighborhood Hits	67	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_HUMAN
NC score	0.716087 (rank : 21)	θ value	4.01107e-24 (rank : 21)
Query Neighborhood Hits	67	Target Neighborhood Hits	102	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
NC score	0.714687 (rank : 22)	θ value	1.42661e-21 (rank : 22)
Query Neighborhood Hits	67	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
NC score	0.642680 (rank : 23)	θ value	1.16975e-15 (rank : 23)
Query Neighborhood Hits	67	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.618717 (rank : 24)	θ value	3.52202e-12 (rank : 24)
Query Neighborhood Hits	67	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.553834 (rank : 25)	θ value	2.13673e-09 (rank : 25)
Query Neighborhood Hits	67	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC34_MOUSE
NC score	0.519022 (rank : 26)	θ value	1.53129e-07 (rank : 28)
Query Neighborhood Hits	67	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.501022 (rank : 27)	θ value	1.53129e-07 (rank : 27)
Query Neighborhood Hits	67	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

CF154_HUMAN
NC score	0.493261 (rank : 28)	θ value	0.00509761 (rank : 33)
Query Neighborhood Hits	67	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

RGP1_HUMAN
NC score	0.383626 (rank : 29)	θ value	2.61198e-07 (rank : 29)
Query Neighborhood Hits	67	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.364729 (rank : 30)	θ value	5.44631e-05 (rank : 32)
Query Neighborhood Hits	67	Target Neighborhood Hits	105	Shared Neighborhood Hits	26
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

ASC_MOUSE
NC score	0.319202 (rank : 31)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	67	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

CAR12_HUMAN
NC score	0.310799 (rank : 32)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	67	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

ASC_HUMAN
NC score	0.265575 (rank : 33)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	67	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIRC1_HUMAN
NC score	0.215998 (rank : 34)	θ value	3.19293e-05 (rank : 31)
Query Neighborhood Hits	67	Target Neighborhood Hits	61	Shared Neighborhood Hits	29
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1A_MOUSE
NC score	0.196961 (rank : 35)	θ value	0.0330416 (rank : 37)
Query Neighborhood Hits	67	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

MEFV_MOUSE
NC score	0.194135 (rank : 36)	θ value	5.26297e-08 (rank : 26)
Query Neighborhood Hits	67	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

BIR1F_MOUSE
NC score	0.188429 (rank : 37)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	67	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.187661 (rank : 38)	θ value	0.125558 (rank : 39)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.180433 (rank : 39)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	67	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.175931 (rank : 40)	θ value	0.365318 (rank : 42)
Query Neighborhood Hits	67	Target Neighborhood Hits	93	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

LRC45_MOUSE
NC score	0.171035 (rank : 41)	θ value	0.00869519 (rank : 34)
Query Neighborhood Hits	67	Target Neighborhood Hits	959	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.160946 (rank : 42)	θ value	0.21417 (rank : 41)
Query Neighborhood Hits	67	Target Neighborhood Hits	933	Shared Neighborhood Hits	33
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CARD8_HUMAN
NC score	0.123527 (rank : 43)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	67	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

MEFV_HUMAN
NC score	0.105037 (rank : 44)	θ value	4.92598e-06 (rank : 30)
Query Neighborhood Hits	67	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC14_HUMAN
NC score	0.083419 (rank : 45)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	67	Target Neighborhood Hits	57	Shared Neighborhood Hits	17
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

CD14_MOUSE
NC score	0.055171 (rank : 46)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	67	Target Neighborhood Hits	104	Shared Neighborhood Hits	11
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

TMOD2_HUMAN
NC score	0.054691 (rank : 47)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	67	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

LRC42_MOUSE
NC score	0.043175 (rank : 48)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	67	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R2U7, Q3TE62, Q9CTP9	Gene names	Lrrc42
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 42.

PHLPP_MOUSE
NC score	0.041815 (rank : 49)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	67	Target Neighborhood Hits	394	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PHLPP_HUMAN
NC score	0.038819 (rank : 50)	θ value	0.62314 (rank : 47)
Query Neighborhood Hits	67	Target Neighborhood Hits	604	Shared Neighborhood Hits	20
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PHLPL_HUMAN
NC score	0.031007 (rank : 51)	θ value	0.365318 (rank : 43)
Query Neighborhood Hits	67	Target Neighborhood Hits	310	Shared Neighborhood Hits	17
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PHLPL_MOUSE
NC score	0.028760 (rank : 52)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	67	Target Neighborhood Hits	303	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

ABTAP_HUMAN
NC score	0.023300 (rank : 53)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	67	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

GP1BA_HUMAN
NC score	0.021712 (rank : 54)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	67	Target Neighborhood Hits	407	Shared Neighborhood Hits	16
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

LRC15_MOUSE
NC score	0.020243 (rank : 55)	θ value	0.62314 (rank : 46)
Query Neighborhood Hits	67	Target Neighborhood Hits	305	Shared Neighborhood Hits	23
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

PIDD_HUMAN
NC score	0.019035 (rank : 56)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	67	Target Neighborhood Hits	271	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

LAP4_MOUSE
NC score	0.017516 (rank : 57)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	67	Target Neighborhood Hits	590	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PDZK4_MOUSE
NC score	0.013828 (rank : 58)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	67	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.013687 (rank : 59)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	67	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LAP4_HUMAN
NC score	0.013429 (rank : 60)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	67	Target Neighborhood Hits	608	Shared Neighborhood Hits	16
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

FBX31_HUMAN
NC score	0.013027 (rank : 61)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	67	Target Neighborhood Hits	55	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

CPN2_MOUSE
NC score	0.012720 (rank : 62)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	67	Target Neighborhood Hits	291	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

ZYGBL_MOUSE
NC score	0.011328 (rank : 63)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	67	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q80ZJ6, Q6PGH5, Q8BG38	Gene names	Zyg11bl, Zyg
Domain Architecture	No domain graphic available
Description	Zyg-11 protein homolog (Zyg-11 homolog B-like).

ZYGBL_HUMAN
NC score	0.011279 (rank : 64)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	67	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z7L7, O00156, Q5T272, Q5T273	Gene names	ZYG11BL, C9orf60, ZYG
Domain Architecture	No domain graphic available
Description	Zyg-11 protein homolog (Zyg-11 homolog B-like).

K0372_HUMAN
NC score	0.005370 (rank : 65)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	67	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

NMDE3_MOUSE
NC score	0.002786 (rank : 66)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	67	Target Neighborhood Hits	86	Shared Neighborhood Hits	3
SwissProt Accessions	Q01098	Gene names	Grin2c
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

NMDE3_HUMAN
NC score	0.002775 (rank : 67)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	67	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q14957	Gene names	GRIN2C
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 3 precursor (N-methyl D- aspartate receptor subtype 2C) (NR2C) (NMDAR2C).

EMR1_HUMAN
NC score	-0.000312 (rank : 68)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	67	Target Neighborhood Hits	382	Shared Neighborhood Hits	3
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

HMMR_MOUSE
NC score	-0.000537 (rank : 69)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	67	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

CCD39_MOUSE
NC score	-0.000593 (rank : 70)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	67	Target Neighborhood Hits	1026	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.