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Network neighborhood for query Sequence : NAL12_HUMAN

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NAL12_HUMAN
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CIAS1_HUMAN
θ value	0 (rank : 1)	NC score	0.987696 (rank : 2)
Query Neighborhood Hits	96	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
θ value	0 (rank : 2)	NC score	0.987031 (rank : 3)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL12_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	96	Target Neighborhood Hits	96	Shared Neighborhood Hits	96
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

NAL14_HUMAN
θ value	4.53388e-177 (rank : 4)	NC score	0.976793 (rank : 4)
Query Neighborhood Hits	96	Target Neighborhood Hits	76	Shared Neighborhood Hits	49
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
θ value	2.19974e-139 (rank : 5)	NC score	0.973527 (rank : 5)
Query Neighborhood Hits	96	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NAL13_HUMAN
θ value	3.51195e-137 (rank : 6)	NC score	0.966900 (rank : 7)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP2_HUMAN
θ value	4.58675e-137 (rank : 7)	NC score	0.969654 (rank : 6)
Query Neighborhood Hits	96	Target Neighborhood Hits	65	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP5_HUMAN
θ value	1.86652e-130 (rank : 8)	NC score	0.960895 (rank : 8)
Query Neighborhood Hits	96	Target Neighborhood Hits	88	Shared Neighborhood Hits	54
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP1_HUMAN
θ value	5.08302e-128 (rank : 9)	NC score	0.927796 (rank : 13)
Query Neighborhood Hits	96	Target Neighborhood Hits	138	Shared Neighborhood Hits	47
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP5_MOUSE
θ value	4.7686e-118 (rank : 10)	NC score	0.892308 (rank : 16)
Query Neighborhood Hits	96	Target Neighborhood Hits	560	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NALP6_HUMAN
θ value	3.0981e-109 (rank : 11)	NC score	0.946103 (rank : 11)
Query Neighborhood Hits	96	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP7_HUMAN
θ value	3.42535e-108 (rank : 12)	NC score	0.960325 (rank : 9)
Query Neighborhood Hits	96	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
θ value	1.06727e-101 (rank : 13)	NC score	0.947435 (rank : 10)
Query Neighborhood Hits	96	Target Neighborhood Hits	66	Shared Neighborhood Hits	40
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP6_MOUSE
θ value	1.88391e-98 (rank : 14)	NC score	0.944673 (rank : 12)
Query Neighborhood Hits	96	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NAL10_HUMAN
θ value	1.70789e-91 (rank : 15)	NC score	0.912633 (rank : 14)
Query Neighborhood Hits	96	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	1.95861e-79 (rank : 16)	NC score	0.907035 (rank : 15)
Query Neighborhood Hits	96	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

RINI_HUMAN
θ value	5.51964e-74 (rank : 17)	NC score	0.886462 (rank : 17)
Query Neighborhood Hits	96	Target Neighborhood Hits	78	Shared Neighborhood Hits	43
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
θ value	1.40689e-69 (rank : 18)	NC score	0.883237 (rank : 18)
Query Neighborhood Hits	96	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CARD4_HUMAN
θ value	1.0531e-32 (rank : 19)	NC score	0.732129 (rank : 21)
Query Neighborhood Hits	96	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CAR15_MOUSE
θ value	6.82597e-32 (rank : 20)	NC score	0.771422 (rank : 19)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
θ value	1.52067e-31 (rank : 21)	NC score	0.757196 (rank : 20)
Query Neighborhood Hits	96	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_MOUSE
θ value	5.97985e-28 (rank : 22)	NC score	0.729326 (rank : 22)
Query Neighborhood Hits	96	Target Neighborhood Hits	85	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
θ value	7.32683e-18 (rank : 23)	NC score	0.656124 (rank : 23)
Query Neighborhood Hits	96	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
θ value	3.63628e-17 (rank : 24)	NC score	0.631808 (rank : 24)
Query Neighborhood Hits	96	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC31_HUMAN
θ value	1.33837e-11 (rank : 25)	NC score	0.537650 (rank : 26)
Query Neighborhood Hits	96	Target Neighborhood Hits	139	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

MEFV_MOUSE
θ value	2.36244e-08 (rank : 26)	NC score	0.186891 (rank : 40)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

LRC34_HUMAN
θ value	9.92553e-07 (rank : 27)	NC score	0.552785 (rank : 25)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

BIRC1_HUMAN
θ value	1.29631e-06 (rank : 28)	NC score	0.254762 (rank : 33)
Query Neighborhood Hits	96	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

LRC34_MOUSE
θ value	2.88788e-06 (rank : 29)	NC score	0.517239 (rank : 27)
Query Neighborhood Hits	96	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

BIR1A_MOUSE
θ value	1.09739e-05 (rank : 30)	NC score	0.238020 (rank : 35)
Query Neighborhood Hits	96	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

MEFV_HUMAN
θ value	1.09739e-05 (rank : 31)	NC score	0.101264 (rank : 44)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC45_MOUSE
θ value	1.87187e-05 (rank : 32)	NC score	0.183664 (rank : 41)
Query Neighborhood Hits	96	Target Neighborhood Hits	959	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

BIR1E_MOUSE
θ value	2.44474e-05 (rank : 33)	NC score	0.230241 (rank : 37)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

RGP1_MOUSE
θ value	3.19293e-05 (rank : 34)	NC score	0.359134 (rank : 30)
Query Neighborhood Hits	96	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

LRC45_HUMAN
θ value	4.1701e-05 (rank : 35)	NC score	0.172915 (rank : 42)
Query Neighborhood Hits	96	Target Neighborhood Hits	933	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

RGP1_HUMAN
θ value	0.000121331 (rank : 36)	NC score	0.376079 (rank : 29)
Query Neighborhood Hits	96	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

BIR1B_MOUSE
θ value	0.00035302 (rank : 37)	NC score	0.218828 (rank : 39)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1F_MOUSE
θ value	0.00175202 (rank : 38)	NC score	0.231388 (rank : 36)
Query Neighborhood Hits	96	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	0.00228821 (rank : 39)	NC score	0.223549 (rank : 38)
Query Neighborhood Hits	96	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

CAR12_HUMAN
θ value	0.00509761 (rank : 40)	NC score	0.356346 (rank : 31)
Query Neighborhood Hits	96	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CD14_MOUSE
θ value	0.00869519 (rank : 41)	NC score	0.081628 (rank : 46)
Query Neighborhood Hits	96	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

CF154_HUMAN
θ value	0.0193708 (rank : 42)	NC score	0.499814 (rank : 28)
Query Neighborhood Hits	96	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

LRRC1_HUMAN
θ value	0.0193708 (rank : 43)	NC score	0.048391 (rank : 59)
Query Neighborhood Hits	96	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

PHLPP_HUMAN
θ value	0.0193708 (rank : 44)	NC score	0.057847 (rank : 50)
Query Neighborhood Hits	96	Target Neighborhood Hits	604	Shared Neighborhood Hits	38
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

LRC8D_HUMAN
θ value	0.0252991 (rank : 45)	NC score	0.048958 (rank : 57)
Query Neighborhood Hits	96	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

LRCH4_MOUSE
θ value	0.0431538 (rank : 46)	NC score	0.042348 (rank : 66)
Query Neighborhood Hits	96	Target Neighborhood Hits	302	Shared Neighborhood Hits	32
SwissProt Accessions	Q921G6	Gene names	Lrch4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4.

LRRC1_MOUSE
θ value	0.0431538 (rank : 47)	NC score	0.047143 (rank : 60)
Query Neighborhood Hits	96	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

PHLPP_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.060330 (rank : 47)
Query Neighborhood Hits	96	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

LRC15_MOUSE
θ value	0.0961366 (rank : 49)	NC score	0.039382 (rank : 71)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	41
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

LRC15_HUMAN
θ value	0.125558 (rank : 50)	NC score	0.034111 (rank : 79)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

FXL14_HUMAN
θ value	0.163984 (rank : 51)	NC score	0.042969 (rank : 64)
Query Neighborhood Hits	96	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_MOUSE
θ value	0.163984 (rank : 52)	NC score	0.042845 (rank : 65)
Query Neighborhood Hits	96	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

SHC3_HUMAN
θ value	0.21417 (rank : 53)	NC score	0.018485 (rank : 87)
Query Neighborhood Hits	96	Target Neighborhood Hits	155	Shared Neighborhood Hits	3
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

XPO2_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.031996 (rank : 81)
Query Neighborhood Hits	96	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

XPO2_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.031981 (rank : 82)
Query Neighborhood Hits	96	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

LRC8D_MOUSE
θ value	0.279714 (rank : 56)	NC score	0.044727 (rank : 63)
Query Neighborhood Hits	96	Target Neighborhood Hits	284	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGR2, Q3UVA9, Q8CI13	Gene names	Lrrc8d, Lrrc5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

PRAM3_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.023252 (rank : 85)
Query Neighborhood Hits	96	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

ASC_MOUSE
θ value	0.47712 (rank : 58)	NC score	0.301480 (rank : 32)
Query Neighborhood Hits	96	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

LAP4_HUMAN
θ value	0.62314 (rank : 59)	NC score	0.034597 (rank : 78)
Query Neighborhood Hits	96	Target Neighborhood Hits	608	Shared Neighborhood Hits	32
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
θ value	0.62314 (rank : 60)	NC score	0.038454 (rank : 74)
Query Neighborhood Hits	96	Target Neighborhood Hits	590	Shared Neighborhood Hits	35
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

SHC3_MOUSE
θ value	0.62314 (rank : 61)	NC score	0.016623 (rank : 88)
Query Neighborhood Hits	96	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

ASC_HUMAN
θ value	1.06291 (rank : 62)	NC score	0.248113 (rank : 34)
Query Neighborhood Hits	96	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

LRC33_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.039069 (rank : 72)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC8E_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.041646 (rank : 68)
Query Neighborhood Hits	96	Target Neighborhood Hits	256	Shared Neighborhood Hits	32
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

FLII_MOUSE
θ value	1.38821 (rank : 65)	NC score	0.039741 (rank : 70)
Query Neighborhood Hits	96	Target Neighborhood Hits	304	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJ28, Q8K095, Q8VI44	Gene names	Flii, Fli1, Fliih
Domain Architecture	No domain graphic available
Description	Protein flightless-1 homolog.

TLR13_MOUSE
θ value	1.38821 (rank : 66)	NC score	0.033971 (rank : 80)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	37
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

AASS_MOUSE
θ value	1.81305 (rank : 67)	NC score	0.014432 (rank : 90)
Query Neighborhood Hits	96	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q99K67, Q9Z1I9	Gene names	Aass, Lorsdh
Domain Architecture
Description	Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor (LKR/SDH) [Includes: Lysine ketoglutarate reductase (EC 1.5.1.8) (LOR) (LKR); Saccharopine dehydrogenase (EC 1.5.1.9) (SDH)].

AIM2_HUMAN
θ value	1.81305 (rank : 68)	NC score	0.045968 (rank : 62)
Query Neighborhood Hits	96	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

LRC57_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.049296 (rank : 55)
Query Neighborhood Hits	96	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D1G5, Q9DC95	Gene names	Lrrc57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

PHLPL_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.048471 (rank : 58)
Query Neighborhood Hits	96	Target Neighborhood Hits	303	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

CPN2_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.028752 (rank : 84)
Query Neighborhood Hits	96	Target Neighborhood Hits	291	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

LRC47_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.041905 (rank : 67)
Query Neighborhood Hits	96	Target Neighborhood Hits	300	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N1G4, Q9ULN5	Gene names	LRRC47, KIAA1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

PHLPL_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.049056 (rank : 56)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PIDD_HUMAN
θ value	3.0926 (rank : 74)	NC score	0.039972 (rank : 69)
Query Neighborhood Hits	96	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

TLR11_MOUSE
θ value	3.0926 (rank : 75)	NC score	0.030949 (rank : 83)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q6R5P0	Gene names	Tlr11
Domain Architecture	No domain graphic available
Description	Toll-like receptor 11 precursor.

TLR3_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.022375 (rank : 86)
Query Neighborhood Hits	96	Target Neighborhood Hits	323	Shared Neighborhood Hits	36
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

LRC39_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.038951 (rank : 73)
Query Neighborhood Hits	96	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGI7	Gene names	Lrrc39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39.

LRCH4_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.035285 (rank : 77)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	33
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

MAPE_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.059432 (rank : 49)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

TMOD3_HUMAN
θ value	4.03905 (rank : 80)	NC score	0.046737 (rank : 61)
Query Neighborhood Hits	96	Target Neighborhood Hits	35	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

CCG8_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.007227 (rank : 96)
Query Neighborhood Hits	96	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXS5, Q9BXT0, Q9BY23	Gene names	CACNG8, CACNG6
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

ELMO1_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.008189 (rank : 93)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q92556, Q29R79, Q96PB0, Q9H0I1	Gene names	ELMO1, KIAA0281
Domain Architecture
Description	Engulfment and cell motility protein 1 (CED-12 homolog).

ELMO1_MOUSE
θ value	5.27518 (rank : 83)	NC score	0.008196 (rank : 92)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BPU7, Q8BSY9, Q8K2C5, Q91ZU3	Gene names	Elmo1
Domain Architecture
Description	Engulfment and cell motility protein 1 (CED-12 homolog).

FLII_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.037302 (rank : 75)
Query Neighborhood Hits	96	Target Neighborhood Hits	318	Shared Neighborhood Hits	40
SwissProt Accessions	Q13045	Gene names	FLII, FLIL
Domain Architecture
Description	Protein flightless-1 homolog.

LRC14_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.095974 (rank : 45)
Query Neighborhood Hits	96	Target Neighborhood Hits	57	Shared Neighborhood Hits	20
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

NPHP4_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.011960 (rank : 91)
Query Neighborhood Hits	96	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

CCG8_MOUSE
θ value	6.88961 (rank : 87)	NC score	0.006650 (rank : 98)
Query Neighborhood Hits	96	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHW2	Gene names	Cacng8
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

DPP3_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.007618 (rank : 95)
Query Neighborhood Hits	96	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NY33, O95748, Q969H2, Q9BV67, Q9HAL6	Gene names	DPP3
Domain Architecture
Description	Dipeptidyl-peptidase 3 (EC 3.4.14.4) (Dipeptidyl-peptidase III) (DPP III) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III).

LRC33_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.036890 (rank : 76)
Query Neighborhood Hits	96	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

TMOD3_MOUSE
θ value	6.88961 (rank : 90)	NC score	0.053228 (rank : 51)
Query Neighborhood Hits	96	Target Neighborhood Hits	34	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

DIRA3_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.006099 (rank : 99)
Query Neighborhood Hits	96	Target Neighborhood Hits	241	Shared Neighborhood Hits	7
SwissProt Accessions	O95661	Gene names	DIRAS3, ARHI, NOEY2, RHOI
Domain Architecture
Description	GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI).

DNM1L_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.003882 (rank : 101)
Query Neighborhood Hits	96	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

LRIG3_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.015198 (rank : 89)
Query Neighborhood Hits	96	Target Neighborhood Hits	601	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

NDUB9_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.007858 (rank : 94)
Query Neighborhood Hits	96	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6M9, Q9UQE8	Gene names	NDUFB9, UQOR22
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B22 subunit) (Complex I-B22) (CI-B22).

NVL_HUMAN
θ value	8.99809 (rank : 95)	NC score	0.004252 (rank : 100)
Query Neighborhood Hits	96	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_MOUSE
θ value	8.99809 (rank : 96)	NC score	0.006688 (rank : 97)
Query Neighborhood Hits	96	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

CARD8_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.124460 (rank : 43)
Query Neighborhood Hits	96	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

TMOD2_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.059623 (rank : 48)
Query Neighborhood Hits	96	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD2_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.050729 (rank : 53)
Query Neighborhood Hits	96	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD4_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.052721 (rank : 52)
Query Neighborhood Hits	96	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD4_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.050384 (rank : 54)
Query Neighborhood Hits	96	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

Hits sorted by NC score

NAL12_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	96	Target Neighborhood Hits	96	Shared Neighborhood Hits	96
SwissProt Accessions	P59046, Q8NEU4, Q9BY26	Gene names	NALP12, PYPAF7, RNO
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 12 (PYRIN-containing APAF1-like protein 7) (Monarch-1) (Regulated by nitric oxide).

CIAS1_HUMAN
NC score	0.987696 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	96	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P20, O75434, Q59H68, Q5JQS8, Q5JQS9, Q6TG35, Q8TCW0, Q8TEU9, Q8WXH9	Gene names	CIAS1, NALP3, PYPAF1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein (Cryopyrin) (NACHT-, LRR- and PYD-containing protein 3) (PYRIN-containing APAF1-like protein 1) (Angiotensin/vasopressin receptor AII/AVP-like).

CIAS1_MOUSE
NC score	0.987031 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4B8, Q6JEL0	Gene names	Cias1, Mmig1, Nalp3, Pypaf1
Domain Architecture
Description	Cold autoinflammatory syndrome 1 protein homolog (PYRIN-containing APAF1-like protein 1) (Mast cell maturation-associated-inducible protein 1) (Cryopyrin).

NAL14_HUMAN
NC score	0.976793 (rank : 4)	θ value	4.53388e-177 (rank : 4)
Query Neighborhood Hits	96	Target Neighborhood Hits	76	Shared Neighborhood Hits	49
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

NALP4_HUMAN
NC score	0.973527 (rank : 5)	θ value	2.19974e-139 (rank : 5)
Query Neighborhood Hits	96	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP2_HUMAN
NC score	0.969654 (rank : 6)	θ value	4.58675e-137 (rank : 7)
Query Neighborhood Hits	96	Target Neighborhood Hits	65	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NAL13_HUMAN
NC score	0.966900 (rank : 7)	θ value	3.51195e-137 (rank : 6)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	45
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP5_HUMAN
NC score	0.960895 (rank : 8)	θ value	1.86652e-130 (rank : 8)
Query Neighborhood Hits	96	Target Neighborhood Hits	88	Shared Neighborhood Hits	54
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NALP7_HUMAN
NC score	0.960325 (rank : 9)	θ value	3.42535e-108 (rank : 12)
Query Neighborhood Hits	96	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NAL11_HUMAN
NC score	0.947435 (rank : 10)	θ value	1.06727e-101 (rank : 13)
Query Neighborhood Hits	96	Target Neighborhood Hits	66	Shared Neighborhood Hits	40
SwissProt Accessions	P59045, Q53ZZ0, Q8NBF5	Gene names	NALP11, NOD17, PYPAF6
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 11 (PYRIN-containing APAF1-like protein 6) (Nucleotide-binding oligomerization domain protein 17).

NALP6_HUMAN
NC score	0.946103 (rank : 11)	θ value	3.0981e-109 (rank : 11)
Query Neighborhood Hits	96	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	P59044	Gene names	NALP6, PYPAF5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5).

NALP6_MOUSE
NC score	0.944673 (rank : 12)	θ value	1.88391e-98 (rank : 14)
Query Neighborhood Hits	96	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WS2, Q8K0L4	Gene names	Nalp6, Pypaf5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 6 (PYRIN-containing APAF1-like protein 5-like).

NALP1_HUMAN
NC score	0.927796 (rank : 13)	θ value	5.08302e-128 (rank : 9)
Query Neighborhood Hits	96	Target Neighborhood Hits	138	Shared Neighborhood Hits	47
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NAL10_HUMAN
NC score	0.912633 (rank : 14)	θ value	1.70789e-91 (rank : 15)
Query Neighborhood Hits	96	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
NC score	0.907035 (rank : 15)	θ value	1.95861e-79 (rank : 16)
Query Neighborhood Hits	96	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NALP5_MOUSE
NC score	0.892308 (rank : 16)	θ value	4.7686e-118 (rank : 10)
Query Neighborhood Hits	96	Target Neighborhood Hits	560	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RINI_HUMAN
NC score	0.886462 (rank : 17)	θ value	5.51964e-74 (rank : 17)
Query Neighborhood Hits	96	Target Neighborhood Hits	78	Shared Neighborhood Hits	43
SwissProt Accessions	P13489	Gene names	RNH1, PRI, RNH
Domain Architecture
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1) (RAI) (Placental ribonuclease inhibitor) (RNase inhibitor) (RI).

RINI_MOUSE
NC score	0.883237 (rank : 18)	θ value	1.40689e-69 (rank : 18)
Query Neighborhood Hits	96	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

CAR15_MOUSE
NC score	0.771422 (rank : 19)	θ value	6.82597e-32 (rank : 20)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CAR15_HUMAN
NC score	0.757196 (rank : 20)	θ value	1.52067e-31 (rank : 21)
Query Neighborhood Hits	96	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CARD4_HUMAN
NC score	0.732129 (rank : 21)	θ value	1.0531e-32 (rank : 19)
Query Neighborhood Hits	96	Target Neighborhood Hits	102	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD4_MOUSE
NC score	0.729326 (rank : 22)	θ value	5.97985e-28 (rank : 22)
Query Neighborhood Hits	96	Target Neighborhood Hits	85	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

C2TA_MOUSE
NC score	0.656124 (rank : 23)	θ value	7.32683e-18 (rank : 23)
Query Neighborhood Hits	96	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

C2TA_HUMAN
NC score	0.631808 (rank : 24)	θ value	3.63628e-17 (rank : 24)
Query Neighborhood Hits	96	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

LRC34_HUMAN
NC score	0.552785 (rank : 25)	θ value	9.92553e-07 (rank : 27)
Query Neighborhood Hits	96	Target Neighborhood Hits	67	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZ02	Gene names	LRRC34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

LRC31_HUMAN
NC score	0.537650 (rank : 26)	θ value	1.33837e-11 (rank : 25)
Query Neighborhood Hits	96	Target Neighborhood Hits	139	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRC34_MOUSE
NC score	0.517239 (rank : 27)	θ value	2.88788e-06 (rank : 29)
Query Neighborhood Hits	96	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DAM1	Gene names	Lrrc34
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 34.

CF154_HUMAN
NC score	0.499814 (rank : 28)	θ value	0.0193708 (rank : 42)
Query Neighborhood Hits	96	Target Neighborhood Hits	36	Shared Neighborhood Hits	29
SwissProt Accessions	Q5JTD7	Gene names	C6orf154
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf154.

RGP1_HUMAN
NC score	0.376079 (rank : 29)	θ value	0.000121331 (rank : 36)
Query Neighborhood Hits	96	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	P46060	Gene names	RANGAP1
Domain Architecture
Description	Ran GTPase-activating protein 1.

RGP1_MOUSE
NC score	0.359134 (rank : 30)	θ value	3.19293e-05 (rank : 34)
Query Neighborhood Hits	96	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	P46061, Q60801	Gene names	Rangap1, Fug1
Domain Architecture
Description	Ran GTPase-activating protein 1.

CAR12_HUMAN
NC score	0.356346 (rank : 31)	θ value	0.00509761 (rank : 40)
Query Neighborhood Hits	96	Target Neighborhood Hits	132	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

ASC_MOUSE
NC score	0.301480 (rank : 32)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	96	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPB4, Q9D2W9	Gene names	Pycard, Asc
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (mASC) (PYD and CARD domain-containing protein).

BIRC1_HUMAN
NC score	0.254762 (rank : 33)	θ value	1.29631e-06 (rank : 28)
Query Neighborhood Hits	96	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

ASC_HUMAN
NC score	0.248113 (rank : 34)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	96	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULZ3, Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8	Gene names	PYCARD, ASC, CARD5, TMS1
Domain Architecture
Description	Apoptosis-associated speck-like protein containing a CARD (hASC) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) (Caspase recruitment domain-containing protein 5).

BIR1A_MOUSE
NC score	0.238020 (rank : 35)	θ value	1.09739e-05 (rank : 30)
Query Neighborhood Hits	96	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1F_MOUSE
NC score	0.231388 (rank : 36)	θ value	0.00175202 (rank : 38)
Query Neighborhood Hits	96	Target Neighborhood Hits	88	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.230241 (rank : 37)	θ value	2.44474e-05 (rank : 33)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.223549 (rank : 38)	θ value	0.00228821 (rank : 39)
Query Neighborhood Hits	96	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
NC score	0.218828 (rank : 39)	θ value	0.00035302 (rank : 37)
Query Neighborhood Hits	96	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

MEFV_MOUSE
NC score	0.186891 (rank : 40)	θ value	2.36244e-08 (rank : 26)
Query Neighborhood Hits	96	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

LRC45_MOUSE
NC score	0.183664 (rank : 41)	θ value	1.87187e-05 (rank : 32)
Query Neighborhood Hits	96	Target Neighborhood Hits	959	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_HUMAN
NC score	0.172915 (rank : 42)	θ value	4.1701e-05 (rank : 35)
Query Neighborhood Hits	96	Target Neighborhood Hits	933	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CARD8_HUMAN
NC score	0.124460 (rank : 43)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	96	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2G2, Q6PGP8, Q96P82	Gene names	CARD8, KIAA0955, NDPP1
Domain Architecture
Description	Caspase recruitment domain-containing protein 8 (Apoptotic protein NDPP1) (DACAR) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor-up-regulated CARD-containing antagonist of CASP9) (TUCAN).

MEFV_HUMAN
NC score	0.101264 (rank : 44)	θ value	1.09739e-05 (rank : 31)
Query Neighborhood Hits	96	Target Neighborhood Hits	431	Shared Neighborhood Hits	18
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

LRC14_HUMAN
NC score	0.095974 (rank : 45)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	96	Target Neighborhood Hits	57	Shared Neighborhood Hits	20
SwissProt Accessions	Q15048	Gene names	LRRC14, KIAA0014
Domain Architecture
Description	Leucine-rich repeat-containing protein 14.

CD14_MOUSE
NC score	0.081628 (rank : 46)	θ value	0.00869519 (rank : 41)
Query Neighborhood Hits	96	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P10810	Gene names	Cd14
Domain Architecture
Description	Monocyte differentiation antigen CD14 precursor (Myeloid cell-specific leucine-rich glycoprotein).

PHLPP_MOUSE
NC score	0.060330 (rank : 47)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	96	Target Neighborhood Hits	394	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

TMOD2_HUMAN
NC score	0.059623 (rank : 48)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	96	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZR1	Gene names	TMOD2, NTMOD
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

MAPE_HUMAN
NC score	0.059432 (rank : 49)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	12
SwissProt Accessions	P78395, O43481, Q8IXN8	Gene names	PRAME, MAPE
Domain Architecture	No domain graphic available
Description	Melanoma antigen preferentially expressed in tumors (Preferentially expressed antigen of melanoma) (OPA-interacting protein 4) (OIP4).

PHLPP_HUMAN
NC score	0.057847 (rank : 50)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	96	Target Neighborhood Hits	604	Shared Neighborhood Hits	38
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

TMOD3_MOUSE
NC score	0.053228 (rank : 51)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	96	Target Neighborhood Hits	34	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JHJ0, Q3TIT1	Gene names	Tmod3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

TMOD4_HUMAN
NC score	0.052721 (rank : 52)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	96	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NZQ9, Q8WVL3, Q9UKH2	Gene names	TMOD4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

TMOD2_MOUSE
NC score	0.050729 (rank : 53)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	96	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JKK7, Q9JLH9	Gene names	Tmod2
Domain Architecture
Description	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod).

TMOD4_MOUSE
NC score	0.050384 (rank : 54)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	96	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLH8	Gene names	Tmod4
Domain Architecture
Description	Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod).

LRC57_MOUSE
NC score	0.049296 (rank : 55)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	96	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D1G5, Q9DC95	Gene names	Lrrc57
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 57.

PHLPL_HUMAN
NC score	0.049056 (rank : 56)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	96	Target Neighborhood Hits	310	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

LRC8D_HUMAN
NC score	0.048958 (rank : 57)	θ value	0.0252991 (rank : 45)
Query Neighborhood Hits	96	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L1W4, Q6UWB2, Q9NVW3	Gene names	LRRC8D, LRRC5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

PHLPL_MOUSE
NC score	0.048471 (rank : 58)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	96	Target Neighborhood Hits	303	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BXA7, Q8BX96	Gene names	Phlppl
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

LRRC1_HUMAN
NC score	0.048391 (rank : 59)	θ value	0.0193708 (rank : 43)
Query Neighborhood Hits	96	Target Neighborhood Hits	282	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
NC score	0.047143 (rank : 60)	θ value	0.0431538 (rank : 47)
Query Neighborhood Hits	96	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

TMOD3_HUMAN
NC score	0.046737 (rank : 61)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	96	Target Neighborhood Hits	35	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NYL9, Q9NT43, Q9NZR0	Gene names	TMOD3
Domain Architecture
Description	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod).

AIM2_HUMAN
NC score	0.045968 (rank : 62)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	96	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	O14862	Gene names	AIM2
Domain Architecture
Description	Interferon-inducible protein AIM2 (Absent in melanoma 2).

LRC8D_MOUSE
NC score	0.044727 (rank : 63)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	96	Target Neighborhood Hits	284	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGR2, Q3UVA9, Q8CI13	Gene names	Lrrc8d, Lrrc5
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8D.

FXL14_HUMAN
NC score	0.042969 (rank : 64)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	96	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N1E6	Gene names	FBXL14, FBL14
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

FXL14_MOUSE
NC score	0.042845 (rank : 65)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	96	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BID8, Q3U2Q9, Q8R5H7, Q8VDT7, Q922N5	Gene names	Fbxl14, Fbl14, Ppa
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14).

LRCH4_MOUSE
NC score	0.042348 (rank : 66)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	96	Target Neighborhood Hits	302	Shared Neighborhood Hits	32
SwissProt Accessions	Q921G6	Gene names	Lrch4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4.

LRC47_HUMAN
NC score	0.041905 (rank : 67)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	96	Target Neighborhood Hits	300	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N1G4, Q9ULN5	Gene names	LRRC47, KIAA1185
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 47.

LRC8E_MOUSE
NC score	0.041646 (rank : 68)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	96	Target Neighborhood Hits	256	Shared Neighborhood Hits	32
SwissProt Accessions	Q66JT1	Gene names	Lrrc8e
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 8E.

PIDD_HUMAN
NC score	0.039972 (rank : 69)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	96	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HB75, Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9NRE6	Gene names	LRDD, PIDD
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and death domain-containing protein (p53-induced protein with a death domain).

FLII_MOUSE
NC score	0.039741 (rank : 70)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	96	Target Neighborhood Hits	304	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JJ28, Q8K095, Q8VI44	Gene names	Flii, Fli1, Fliih
Domain Architecture	No domain graphic available
Description	Protein flightless-1 homolog.

LRC15_MOUSE
NC score	0.039382 (rank : 71)	θ value	0.0961366 (rank : 49)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	41
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

LRC33_HUMAN
NC score	0.039069 (rank : 72)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC39_MOUSE
NC score	0.038951 (rank : 73)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	96	Target Neighborhood Hits	269	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGI7	Gene names	Lrrc39
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 39.

LAP4_MOUSE
NC score	0.038454 (rank : 74)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	96	Target Neighborhood Hits	590	Shared Neighborhood Hits	35
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

FLII_HUMAN
NC score	0.037302 (rank : 75)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	96	Target Neighborhood Hits	318	Shared Neighborhood Hits	40
SwissProt Accessions	Q13045	Gene names	FLII, FLIL
Domain Architecture
Description	Protein flightless-1 homolog.

LRC33_MOUSE
NC score	0.036890 (rank : 76)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	96	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRCH4_HUMAN
NC score	0.035285 (rank : 77)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	33
SwissProt Accessions	O75427, Q8WV85, Q96ID0	Gene names	LRCH4, LRN, LRRN4
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 4 (Leucine-rich neuronal protein).

LAP4_HUMAN
NC score	0.034597 (rank : 78)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	96	Target Neighborhood Hits	608	Shared Neighborhood Hits	32
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LRC15_HUMAN
NC score	0.034111 (rank : 79)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	96	Target Neighborhood Hits	305	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

TLR13_MOUSE
NC score	0.033971 (rank : 80)	θ value	1.38821 (rank : 66)
Query Neighborhood Hits	96	Target Neighborhood Hits	335	Shared Neighborhood Hits	37
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

XPO2_HUMAN
NC score	0.031996 (rank : 81)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	96	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P55060, O75432, Q32M40, Q9H5B7, Q9NTS0, Q9UP98, Q9UP99, Q9UPA0	Gene names	CSE1L, CAS, XPO2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein) (Cellular apoptosis susceptibility protein).

XPO2_MOUSE
NC score	0.031981 (rank : 82)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	96	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ERK4	Gene names	Cse1l, Xpo2
Domain Architecture
Description	Exportin-2 (Exp2) (Importin-alpha re-exporter) (Chromosome segregation 1-like protein).

TLR11_MOUSE
NC score	0.030949 (rank : 83)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	96	Target Neighborhood Hits	293	Shared Neighborhood Hits	36
SwissProt Accessions	Q6R5P0	Gene names	Tlr11
Domain Architecture	No domain graphic available
Description	Toll-like receptor 11 precursor.

CPN2_MOUSE
NC score	0.028752 (rank : 84)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	96	Target Neighborhood Hits	291	Shared Neighborhood Hits	36
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

PRAM3_HUMAN
NC score	0.023252 (rank : 85)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	96	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

TLR3_HUMAN
NC score	0.022375 (rank : 86)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	96	Target Neighborhood Hits	323	Shared Neighborhood Hits	36
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

SHC3_HUMAN
NC score	0.018485 (rank : 87)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	96	Target Neighborhood Hits	155	Shared Neighborhood Hits	3
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
NC score	0.016623 (rank : 88)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	96	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

LRIG3_HUMAN
NC score	0.015198 (rank : 89)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	96	Target Neighborhood Hits	601	Shared Neighborhood Hits	31
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

AASS_MOUSE
NC score	0.014432 (rank : 90)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	96	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q99K67, Q9Z1I9	Gene names	Aass, Lorsdh
Domain Architecture
Description	Alpha-aminoadipic semialdehyde synthase, mitochondrial precursor (LKR/SDH) [Includes: Lysine ketoglutarate reductase (EC 1.5.1.8) (LOR) (LKR); Saccharopine dehydrogenase (EC 1.5.1.9) (SDH)].

NPHP4_MOUSE
NC score	0.011960 (rank : 91)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	96	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

ELMO1_MOUSE
NC score	0.008196 (rank : 92)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BPU7, Q8BSY9, Q8K2C5, Q91ZU3	Gene names	Elmo1
Domain Architecture
Description	Engulfment and cell motility protein 1 (CED-12 homolog).

ELMO1_HUMAN
NC score	0.008189 (rank : 93)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	96	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q92556, Q29R79, Q96PB0, Q9H0I1	Gene names	ELMO1, KIAA0281
Domain Architecture
Description	Engulfment and cell motility protein 1 (CED-12 homolog).

NDUB9_HUMAN
NC score	0.007858 (rank : 94)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	96	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6M9, Q9UQE8	Gene names	NDUFB9, UQOR22
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase B22 subunit) (Complex I-B22) (CI-B22).

DPP3_HUMAN
NC score	0.007618 (rank : 95)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	96	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NY33, O95748, Q969H2, Q9BV67, Q9HAL6	Gene names	DPP3
Domain Architecture
Description	Dipeptidyl-peptidase 3 (EC 3.4.14.4) (Dipeptidyl-peptidase III) (DPP III) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III).

CCG8_HUMAN
NC score	0.007227 (rank : 96)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	96	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXS5, Q9BXT0, Q9BY23	Gene names	CACNG8, CACNG6
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

NVL_MOUSE
NC score	0.006688 (rank : 97)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	96	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

CCG8_MOUSE
NC score	0.006650 (rank : 98)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	96	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHW2	Gene names	Cacng8
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

DIRA3_HUMAN
NC score	0.006099 (rank : 99)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	96	Target Neighborhood Hits	241	Shared Neighborhood Hits	7
SwissProt Accessions	O95661	Gene names	DIRAS3, ARHI, NOEY2, RHOI
Domain Architecture
Description	GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI).

NVL_HUMAN
NC score	0.004252 (rank : 100)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	96	Target Neighborhood Hits	112	Shared Neighborhood Hits	5
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

DNM1L_HUMAN
NC score	0.003882 (rank : 101)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	96	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).